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Journal articles on the topic 'CCR5'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Korbecki, Jan, Klaudyna Kojder, Katarzyna Barczak, et al. "Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review." International Journal of Molecular Sciences 21, no. 16 (2020): 5647. http://dx.doi.org/10.3390/ijms21165647.

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Hypoxia, i.e., oxygen deficiency condition, is one of the most important factors promoting the growth of tumors. Since its effect on the chemokine system is crucial in understanding the changes in the recruitment of cells to a tumor niche, in this review we have gathered all the available data about the impact of hypoxia on β chemokines. In the introduction, we present the chronic (continuous, non-interrupted) and cycling (intermittent, transient) hypoxia together with the mechanisms of activation of hypoxia inducible factors (HIF-1 and HIF-2) and NF-κB. Then we describe the effect of hypoxia

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Princen, Katrien, Sigrid Hatse, Kurt Vermeire, et al. "Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist." Journal of Virology 78, no. 23 (2004): 12996–3006. http://dx.doi.org/10.1128/jvi.78.23.12996-13006.2004.

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ABSTRACT Here we report that the N-pyridinylmethyl cyclam analog AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2 (50% inhibitory concentration [IC50] ranging from 1.2 to 26.5 μM) in various T-cell lines, CCR5- or CXCR4-transfected cells, peripheral blood mononuclear cells (PBMCs), and monocytes/macrophages. AMD3451 also inhibited R5, R5/X4, and X4 HIV-1 primary clinical isolates in PBMCs (IC50, 1.8 to 7.3 μM). A PCR-based viral entry assay revealed that AMD3451 blocks R5 and X4 HIV-1 infection at the vi

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Zhang, Yi-jun, Tatjana Dragic, Yunzhen Cao, et al. "Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro." Journal of Virology 72, no. 11 (1998): 9337–44. http://dx.doi.org/10.1128/jvi.72.11.9337-9344.1998.

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ABSTRACT We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal

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4

Yoon, Sunjoo, Ju Hyun Lee, Minsu Kang, et al. "Abstract 5951: The correlation between single nucleotide polymorphism of chemokine receptor and ligand and infiltrating immune cells on tumor microenvironment of gastric cancer." Cancer Research 83, no. 7_Supplement (2023): 5951. http://dx.doi.org/10.1158/1538-7445.am2023-5951.

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Abstract Objective: Chemokines play roles in many normal biological processes, such as hematopoietic cell genesis and leukocyte migration and homing. Chemokines could be responsible for eliciting local accumulation of immune cells within tumor microenvironment. In this study, we examine if genetic variations in chemokine receptor and ligand are associated with infiltrations of immune cells on tumor microenvironment in gastric cancer. Methods: In 356 gastric cancer patients who received curative surgery followed by adjuvant chemotherapy, total 105 single nucleotide polymorphisms (SNP) in a chem

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Taylor, James R., Katherine C. Kimbrell, Robert Scoggins, Marie Delaney, Lijun Wu, and David Camerini. "Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1." Journal of Virology 75, no. 18 (2001): 8752–60. http://dx.doi.org/10.1128/jvi.75.18.8752-8760.2001.

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ABSTRACT The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We assayed the expression and function of the major HIV-1 coreceptors, CCR5 and CXCR4, as well as CCR4 and CCR7 as controls, on human thymocytes. We detected CCR5 on 2.5% of thymocytes, CXCR4 on 53% of the cells, and CCR4 on 16% and CCR7 on 11% of human thymocytes. Moreover,

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Mazur, Grzegorz, Emilia Jaskula, Ilona Kryczek, et al. "Gene Expression for Chemokine Receptors Influences Survival of Non-Hodgkin Lymphoma Patients." Blood 116, no. 21 (2010): 3103. http://dx.doi.org/10.1182/blood.v116.21.3103.3103.

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Abstract Abstract 3103 Non-Hodgkin's lymphoma (nHL) represent heterogenous group of lymphoid malignancies derived from B and T lymphocytes, NK cells or histiocytes. Most of lymphomas are B-cell origin. Lymphoma cells can migrate to other organs and their migration could be linked to chemokines and their receptors. Chemokine receptors are expressed by many cell populations, including lymphoid cells, and their main function is lymphocytes. Chemokine receptors guide lymphocytes homing, chemotaxis, adhesion and interplaying between immunologic system response cells. They are also responsible for c

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Ren, Han-Yun, Meng Wang, Xiang-Juan Ma, Yu-Jun Dong, Zhi-Xiang Qiu, and Wei Liu. "Differential Regulation Of Chemokine Receptor Expressions On T Lymphocyte Subsets In Healthy Donors After Mobilization With Rhg-CSF and Its Correlation With Acute GvHD." Blood 122, no. 21 (2013): 3296. http://dx.doi.org/10.1182/blood.v122.21.3296.3296.

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Abstract Introduction This study is aimed to investigate chemokine receptors (CCR5, CCR6, CCR7, CCR9, CXCR3 and CCR2) expression on T cell subsets in healthy donors after mobilization with recombinant human granulocyte colony-stimulating factor (rhG-CSF) and analyze its correlation with acute graft-versus-host disease (aGVHD) and to understand the possible mechanisms underlying rhG-CSF-induced immune tolerance. Methods Sixty-eight healthy donor and their recipient pairs of family donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) were included in this study. The expressions o

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Kim, Chang H., Jeeho Lee, and Seung G. Kang. "Developmental and antigen-driven switches in the trafficking receptors of FoxP3+ regulatory T cells (99.2)." Journal of Immunology 178, no. 1_Supplement (2007): S194. http://dx.doi.org/10.4049/jimmunol.178.supp.99.2.

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Abstract FoxP3+ regulatory T cells play important roles in immune regulation and tolerance. There is an increasing body of evidence that the migration ability of FoxP3+ T cells is important for their regulatory functions at effector tissue sites. We investigated the two different trafficking receptor switches of FoxP3+ T cells occurring in the thymus and secondary lymphoid tissues. The first trafficking receptor switch in the thymus is developmentally programmed: Precursors of FoxP3+ cells undergo the first trafficking receptor switch from CCR8/CCR9 to CXCR4 and then finally to CCR7, generatin

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Paula Costa, Guilherme de, Laís Roquete Lopes, Maria Cláudia da Silva, et al. "Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from ChronicTrypanosoma cruzi-Infected Dogs." Mediators of Inflammation 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3694714.

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Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by theTrypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac tissue. Thirty mongrel dogs were infected, or not, with the Berenice-78 strain ofT. cruziand grouped according their treatments: (i) two months after infection, Dox (50 mg/kg) 2x/day for 12 months; (ii) nine months after infection, Bz (3,5 mg/kg) 2x/day for 60 days; (iii) Dox + Bz;

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Zvejniece, Laura, Svetlana Kozireva, Zanna Rudevica, et al. "Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2." International Journal of Molecular Sciences 23, no. 7 (2022): 3434. http://dx.doi.org/10.3390/ijms23073434.

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Chemokines and their receptors regulate the migration of immune cells and the dissemination of cancer cells. CCR1, CCR2, CCR3, and CCR5 all belong to a single protein homology cluster and respond to the same inflammatory chemokines. We previously reported that CCR1 and CCR2B are induced upon Epstein-Barr virus (EBV) infection of B cells in vitro. EBV is present in almost all cases of endemic Burkitt lymphoma (BL); however, the contribution of EBV in the pathogenesis of the disease is not fully understood. Here, we analyzed the relation of the expression of CCR1, CCR2, CCR3, and CCR5, the EBV D

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Catusse, Julie, Chris M. Parry, David R. Dewin, and Ursula A. Gompels. "Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization." Blood 109, no. 9 (2007): 3633–39. http://dx.doi.org/10.1182/blood-2006-08-042622.

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AbstractHIV-1 strains use C-C-chemokine receptor 5, CCR5, as a coreceptor for host transmission. Human CCR5 chemokine ligands inhibit binding and infection, whereas CCR5 mutations also inhibit infection by preventing surface expression, resulting in delayed progression to AIDS. Here, we describe a human herpesvirus 6 (HHV-6A) chemokine, U83A, which binds CCR5 with higher affinity than human chemokines, displacing their binding and leading to inhibition of chemotaxis of human leukocytes. Similarly, U83A inhibits infection by HIV-1 strains which use CCR5, but not the CXCR4, coreceptor. Unlike hu

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Ortega Moreno, L., S. Fernández Tomé, M. Chaparro, et al. "P045 Profiling of human circulating dendritic cells and monocytes subsets discriminates type and mucosal status in patients with inflammatory bowel disease." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S155—S156. http://dx.doi.org/10.1093/ecco-jcc/jjz203.174.

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Abstract Background Intestinal dendritic cells (DCs) and macrophages govern the mechanisms of immune homeostasis having a role in inflammatory bowel disease (IBD) onset. However, the profile of their circulating precursors (DC and monocytes) in IBD has not been previously described in depth. Our aim was to characterise blood DC and monocyte subsets in healthy controls (HCs) and IBD patients in order to understand their potential implication in IBD pathogenesis. Methods 18 HC and 64 IBD patients were recruited. IBD patients were categorised into Crohn’s disease (CD) and ulcerative colitis (UC),

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Stenstad, Hanna, Anna Ericsson, Bengt Johansson-Lindbom, et al. "Gut-associated lymphoid tissue–primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine." Blood 107, no. 9 (2006): 3447–54. http://dx.doi.org/10.1182/blood-2005-07-2860.

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CD4+ T-cell entry to the intestinal mucosa is central to the generation of mucosal immunity as well as chronic intestinal inflammation, yet the mechanisms regulating this process remain poorly defined. Here we show that murine small intestinal CD4+ lamina propria lymphocytes express a heterogeneous but restricted array of chemokine receptors including CCR5, CCR6, CCR9, CXCR3, and CXCR6. CD4+ T-cell receptor transgenic OT-II cells activated in mesenteric lymph nodes acquired a distinct chemokine receptor profile, including expression of CCR6, CCR9, and CXCR3 that was only partially reproduced i

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Chu, Yuan-Tung, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, and Wan-Chung Hu. "Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological Pathways." Biomedicines 11, no. 9 (2023): 2384. http://dx.doi.org/10.3390/biomedicines11092384.

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A comprehensive framework has been established for understanding immunological pathways, which can be categorized into eradicated and tolerable immune responses. Toll-like receptors (TLRs) are associated with specific immune responses. TH1 immunity is related to TLR7, TLR8, and TLR9, while TH2 immunity is associated with TLR1, TLR2, and TLR6. TH22 immunity is linked to TLR2, TLR4, and TLR5, and THαβ (Tr1) immunity is related to TLR3, TLR7, and TLR9. The chemokine receptor CXCR5 is a marker of follicular helper T cells, and other chemokine receptors can also be classified within a framework bas

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Wenzl, Kerstin, Katharina Troppan, Alexander JA Deutsch, Werner Linkesch, Peter Neumeister, and Christine Beham-Schmid. "Distinct Chemokine Receptor Profile In Chronic Lymphocytic Leukaemia and Richter Transformed Diffuse Large B Cell Lymphomas Compared To Germinal Center B Cells and De Novo Diffuse Large B Cell Lymphomas." Blood 122, no. 21 (2013): 4852. http://dx.doi.org/10.1182/blood.v122.21.4852.4852.

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Abstract Chemokine receptors are G-protein-coupled cell surface receptors, which dissociate upon activation by their ligands and cause downstream signaling. Recently, several studies have revealed the crucial contribution of chemokine receptors and their ligands in normal B-cell differentiation and development of hematopoietic malignancies. The Richter syndrome (RS) represents the clinico-pathologic transformation of chronic lymphocytic leukaemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). Due to the lack of knowledge on the chemokine receptors in RS,

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ANDERS, HANS-JOACHIM, VOLKER VIELHAUER, MATTHIAS KRETZLER, et al. "Chemokine and Chemokine Receptor Expression during Initiation and Resolution of Immune Complex Glomerulonephritis." Journal of the American Society of Nephrology 12, no. 5 (2001): 919–31. http://dx.doi.org/10.1681/asn.v125919.

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Abstract. Chemokines participate in leukocyte infiltration, which plays a major role in glomerular injury during immune complex glomerulonephritis (IC-GN). Because target cell expression of chemokine receptors (CCR) is thought to mediate leukocyte migration, the expression pattern of chemokines and CCR in a model of IC-GN was examined. The transient course and predominant glomerular pathology of this model allows the examination of both the induction and resolution phases of IC-GN. GN was induced in mice by daily apoferritin injection for 2 wk. Urine samples and kidneys were obtained at 1, 2,

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Fox, James M., Elisa Letellier, Christopher J. Oliphant, and Nathalie Signoret. "TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes." Blood 117, no. 6 (2011): 1851–60. http://dx.doi.org/10.1182/blood-2010-05-287474.

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Abstract During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5. Toll-like receptors also play an essential role, allowing pathogen recognition by the recruited monocytes. Here, we demonstrate that Toll-like receptor 2 (TLR2) stimulation by lipoteichoic acid (LTA) from Staphylococcus aureus leads to gradual down-modulation of CCR1, CCR2, and CCR5 from the plasma membrane of human blood-isolated monocytes and inhibits chemotaxis. Inter

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Kim, Chang H., Brent Johnston та Eugene C. Butcher. "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+Vβ11+ NKT cell subsets with distinct cytokine-producing capacity". Blood 100, № 1 (2002): 11–16. http://dx.doi.org/10.1182/blood-2001-12-0196.

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Abstract Natural killer T (NKT) cells are important regulators of the immune system, but their trafficking machinery, including expression of chemokine receptors, has been poorly defined. Unlike other conventional T-cell populations, we show that most NKT cells express receptors for extralymphoid tissue or inflammation-related chemokines (CCR2, CCR5, and CXCR3), while few NKT cells express lymphoid tissue–homing chemokine receptors (CCR7 and CXCR5). A population with homing potential for lymph nodes (L selectin+ CCR7+) exists only within a small subset of CD4 NKT cells. We show differential ex

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Zilio, Serena, Silvio Bicciato, Donald Weed, and Paolo Serafini. "CCR1 and CCR5 mediate cancer-induced myelopoiesis and differentiation of myeloid cells in the tumor." Journal for ImmunoTherapy of Cancer 10, no. 1 (2022): e003131. http://dx.doi.org/10.1136/jitc-2021-003131.

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BackgroundCancer-induced ‘emergency’ myelopoiesis plays a key role in tumor progression by inducing the accumulation of myeloid cells with a suppressive phenotype peripherally and in the tumor. Chemokine receptors (CCRs) and, in particular, CCR1, CCR2, CCR5, and CCR7 are emerging as key regulators of myeloid cell trafficking and function but their precise role has not been completely clarified yet because of the signal redundancy, integration, and promiscuity of chemokines and of the expression of these CCRs on other leukocyte subsets.MethodsWe used the 4PD nanoparticle for the in vivo targete

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Soto-Rodriguez, Guadalupe, Juan-Antonio Gonzalez-Barrios, Daniel Martinez-Fong, et al. "Analysis of Chemokines and Receptors Expression Profile in the Myelin MutantTaiepRat." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/397310.

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Taieprat has a failure in myelination and remyelination processes leading to a state of hypomyelination throughout its life. Chemokines, which are known to play a role in inflammation, are also involved in the remyelination process. We aimed to demonstrate that remyelination-stimulating factors are altered in the brainstem of 1- and 6-month-oldtaieprats. We used a Rat RT2Profiler PCR Array to assess mRNA expression of 84 genes coding for cytokines, chemokines, and their receptors. We also evaluated protein levels of CCL2, CCR1, CCR2, CCL5, CCR5, CCR8, CXCL1, CXCR2, CXCR4, FGF2, and VEGFA by EL

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Rawat, Kavita, Anita Tewari, Xin Li, et al. "A CCL5 chemokine trail laid down by migratory dendritic cells directs CCR5 +antigen-presenting monocytes into draining lymph nodes." Journal of Immunology 210, no. 1_Supplement (2023): 221.01. http://dx.doi.org/10.4049/jimmunol.210.supp.221.01.

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Abstract Antigen presenting dendritic cells (DCs) and monocytes capture and transport antigens from barrier tissues for presentation to antigen-specific T cells in the draining-lymph nodes (LNs). While DCs enter LNs through afferent lymphatics in a CCR7-dependent manner, how exactly antigen-carrying monocytes reach LNs is less clear since monocytes do not express CCR7 and can also enter LNs via the bloodstream. In steady state, and following injection of several PAMPs, scRNA-seq data on LN mononuclear phagocytes identified LN resident versus migratory type 1 and type 2 conventional (c)DCs desp

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Sullivan, Nicole L., Christopher S. Eickhoff, Olivia K. Giddings, Daniel F. Hoft, and Thomas E. Lane. "CCR5 is not required for mucosal protection against Trypanosoma cruzi (39.28)." Journal of Immunology 182, no. 1_Supplement (2009): 39.28. http://dx.doi.org/10.4049/jimmunol.182.supp.39.28.

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Abstract Trypanosoma cruzi is an intracellular obligate parasite and the causative agent of Chagas disease. Previous work has shown that the chemokine receptor CCR5 plays a role in systemic responses against T. cruzi. We evaluated whether CCR5 plays a critical role in mucosal protection against natural oral and conjunctival challenges. Memory-immune CCR5-/- and wild-type C57BL/6 mice were generated by repeated infectious challenges with sublethal doses of insect-derived metacyclic trypomastigotes. Similar IgA, IgG and IFN-γ responses were detected in the spleen in both memory-immune and primar

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Abid, Shariq, Elisabeth Marcos, Aurélien Parpaleix, et al. "CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension." European Respiratory Journal 54, no. 4 (2019): 1802308. http://dx.doi.org/10.1183/13993003.02308-2018.

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Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH).To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (PASMCs) collaborate to stimulate PASMC growth and whether the CCL2-CCR2 and CCL5-CCR5 pathways inhibited macrophage–PASMC interactions and PAH development, we used human CCR5-knock-in mice and PASMCs from patients with PAH and controls.Conditioned media from murine M1 or M2 macrophages stimulated PASMC growth. This effect was markedly amplified with conditioned media from M2 macrophage/PASMC co-cultures. CCR2, CCR5, CCL2 an

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Raghu, Harini, Christin M. Lepus, Qian Wang, et al. "CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis." Annals of the Rheumatic Diseases 76, no. 5 (2016): 914–22. http://dx.doi.org/10.1136/annrheumdis-2016-210426.

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ObjectivesWhile various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis.MethodsCcl2-, Ccr2-, Ccl5- and Ccr5-deficient and control mice were subjected to destabilisation of medial meniscus surgery to induce OA. The pharmacological utility of blocking CCL2/CCR2 signalling in mouse OA was investigated using bindarit,

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Deutsch, Alexander J. A., Ariane Aigelsreiter, Elisabeth Steinbauer, et al. "Chemokine Receptor Expression Profile in the Model of Parotid MALT Lymphomagenesis: De Novo Expression of CXCR6." Blood 110, no. 11 (2007): 2622. http://dx.doi.org/10.1182/blood.v110.11.2622.2622.

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Abstract Chemokine receptors mediate migration and activation of lymphocytes through binding of their ligands. Several recent studies have revealed important contributions of chemokine receptors and their ligands to the development and progression/dissemination of hematopoietic neoplasms. Strong expression of CXCR5 and its ligand BCA-1 was detected in transformed B cells in H. pylori positive gastric MALT lymphoma. Because the knowledge of chemokine receptor expression in parotid MALT lymphoma is limited, we performed a comprehensive study on tissue samples of parotid glands (P), parotid gland

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Uhl, Barbara, Katharina T. Prochazka, Katrin Pansy, et al. "Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter’s Trans-Formed DLBCL and Germinal Center B-Cells." International Journal of Molecular Sciences 23, no. 14 (2022): 7874. http://dx.doi.org/10.3390/ijms23147874.

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Chemokine receptors and their ligands have been identified as playing an important role in the development of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, and Richter syndrome (RS). Our aim was to investigate the different expression profiles in de novo DLBCL, transformed follicular lymphoma (tFL), and RS. Here, we profiled the mRNA expression levels of 18 chemokine receptors (CCR1–CCR9, CXCR1–CXCR7, CX3CR1 and XCR1) using RQ-PCR, as well as immunohistochemistry of seven chemokine receptors (CCR1, CCR4–CCR8 and CXCR2) in RS, de novo DLBCL, and tFL biopsy-derived tissues. Tonsil-

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Gomes, Juliana A. S., Lilian M. G. Bahia-Oliveira, Manoel Otávio C. Rocha, et al. "Type 1 Chemokine Receptor Expression in Chagas' Disease Correlates with Morbidity in Cardiac Patients." Infection and Immunity 73, no. 12 (2005): 7960–66. http://dx.doi.org/10.1128/iai.73.12.7960-7966.2005.

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ABSTRACT Chemokines and chemokine receptors (CKRs) control the migration of leukocytes during the inflammatory process and are important immunological markers of type 1 (CCR5 and CXCR3) and type 2 (CCR3 and CCR4) responses. The coexpression of CKRs (CCR2, CCR3, CCR5, CXCR3, and CXCR4) and intracellular cytokines (interleukin-10 [IL-10], IL-4, tumor necrosis factor alpha [TNF-α], and gamma interferon [IFN-γ]) on T CD4+ and CD8+ peripheral cells from individuals with indeterminate (IND) or cardiac (CARD) clinical forms of Chagas' disease after in vitro stimulation with Trypanosoma cruzi antigens

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Barroso-González, Jonathan, Nabil El Jaber-Vazdekis, Laura García-Expósito, et al. "The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities." Journal of Biological Chemistry 284, no. 24 (2009): 16609–20. http://dx.doi.org/10.1074/jbc.m109.005835.

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The existence of drug-resistant human immunodeficiency virus (HIV) viruses in patients receiving antiretroviral treatment urgently requires the characterization and development of new antiretroviral drugs designed to inhibit resistant viruses and to complement the existing antiretroviral strategies against AIDS. We assayed several natural or semi-synthetic lupane-type pentacyclic triterpenes in their ability to inhibit HIV-1 infection in permissive cells. We observed that the 30-oxo-calenduladiol triterpene, compound 1, specifically impaired R5-tropic HIV-1 envelope-mediated viral infection an

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Sallusto, Federica, Danielle Lenig, Charles R. Mackay, and Antonio Lanzavecchia. "Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes." Journal of Experimental Medicine 187, no. 6 (1998): 875–83. http://dx.doi.org/10.1084/jem.187.6.875.

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Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional subsets of T cells, chemokine receptor expression was analyzed using monoclonal antibodies, RNase protection assays, and the response to distinct chemokines. Naive T cells expressed only CXC chemokine receptor (CXCR)4, whereas the majority of memory/activated T cells expressed CXCR3, and a small proportion expressed CC chemokine receptor (CCR)3 and CCR5. When polarized T cell lines were analyzed, CXCR3 was found to be ex

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Korbecki, Jan, Szymon Grochans, Izabela Gutowska, Katarzyna Barczak, and Irena Baranowska-Bosiacka. "CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands." International Journal of Molecular Sciences 21, no. 20 (2020): 7619. http://dx.doi.org/10.3390/ijms21207619.

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CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system cells, such as CD4+ and CD8+ lymphocytes, dendritic cells, eosinophils, macrophages, monocytes, and NK cells, as well in neoplasia. In this review, we discuss human CC motif chemokine ligands: CCL1, CCL3, CCL4, CCL5, CCL18, CCL19, CCL20, CCL21, CCL25, CCL27, and CCL28 (CC motif chemokine receptor CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands). We present their functioning in human physiology and in neoplasia, including their role in the proliferation, apoptos

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VIELHAUER, VOLKER, HANS-JOACHIM ANDERS, MATTHIAS MACK, et al. "Obstructive Nephropathy in the Mouse: Progressive Fibrosis Correlates with Tubulointerstitial Chemokine Expression and Accumulation of CC Chemokine Receptor 2- and 5-Positive Leukocytes." Journal of the American Society of Nephrology 12, no. 6 (2001): 1173–87. http://dx.doi.org/10.1681/asn.v1261173.

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Abstract. The infiltration of leukocytes plays a major role in mediating tubulointerstitial inflammation and fibrosis in chronic renal disease. CC chemokines participate in leukocyte migration and infiltration into inflamed renal tissue. Because CC chemokine-directed leukocyte migration is mediated by target cell expression of a group of CC chemokine receptors, this study examined the expression of CC chemokines and their receptors during initiation of tubulointerstitial fibrosis after unilateral ureteral obstruction in C57BL/6 mice. Obstructed kidneys developed hydronephrosis, tubular cell da

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Clark, D. J., J. Catusse, A. Stacey, P. Borrow, and U. A. Gompels. "Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide." Journal of General Virology 94, no. 7 (2013): 1624–35. http://dx.doi.org/10.1099/vir.0.050153-0.

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Human monocytes expressing CCR2 with CD14 and CD16 can mediate antigen presentation, and promote inflammation, brain infiltration and immunosenescence. Recently identified roles are in human immunodeficiency virus infection, tuberculosis and parasitic disease. Human herpesvirus 6B (HHV-6B) encodes a chemokine, U83B, which is monospecific for CCR2, and is distinct from the related HHV-6A U83A, which activates CCR1, CCR4, CCR5, CCR6 and CCR8 on immune effector cells and dendritic cells. These differences could alter leukocyte-subset recruitment for latent/lytic replication and associated neuroin

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Zernecke, Alma, Elisa A. Liehn, Ji-Liang Gao, William A. Kuziel, Philip M. Murphy, and Christian Weber. "Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10." Blood 107, no. 11 (2006): 4240–43. http://dx.doi.org/10.1182/blood-2005-09-3922.

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AbstractThe chemokine RANTES has been implicated in neointimal hyperplasia after arterial injury. We analyzed the differential role of the RANTES receptors CCR1 and CCR5 by genetic deletion in apolipoprotein E–deficient mice. Deficiency in CCR5 significantly reduced neointimal area after arterial wire injury, associated with a decrease in macrophages, CD3+ T lymphocytes, and CCR2+ cells. In contrast, CCR1 deficiency did not affect neointimal area or cell content. Deletion of CCR5 entailed an up-regulation of the anti-inflammatory cytokine interleukin 10 (IL-10) in neointimal smooth muscle cell

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Kramp, Birgit K., Remco T. A. Megens, Alisina Sarabi, et al. "Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment." Thrombosis and Haemostasis 110, no. 10 (2013): 795–806. http://dx.doi.org/10.1160/th13-05-0420.

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SummaryThe chemokine CCL5 recruits monocytes into inflamed tissues by triggering primarily CCR1-mediated arrest on endothelial cells, whereas subsequent spreading is dominated by CCR5. The CCL5-induced arrest can be enhanced by heteromer formation with CXCL4. To identify mechanisms for receptor-specific functions, we employed CCL5 mutants and transfectants expressing receptor chimeras carrying transposed extracellular regions. Mutation of the basic 50s cluster of CCL5, a coordinative site for CCL5 surface presentation, reduced CCR5- but not CCR1-mediated arrest and transmigration. Impaired arr

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Wang, Meng, Han-Yun Ren, Yu-Jun Dong, et al. "Association Of Chemokine Receptor CCR5, CCR6 and CCR7 Expressions On T Lymphocyte Subsets In Recipients After Allo-HSCT With Acute GvHD." Blood 122, no. 21 (2013): 4596. http://dx.doi.org/10.1182/blood.v122.21.4596.4596.

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Introduction To study the correlation of chemokine receptors expression on T lymphocyte subsets in recipients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with acute graft-versus-host disease (acute GVHD). Methods Forty-four recipients of family donor allogeneic hematopoietic stem cell transplantation were included in this study. According to the severity of acute GVHD, the recipients were divided into Grade II-IV acute GVHD group (n=16) and Grade 0-I acute GVHD group (n=28). Additionally,fifty healthy donors were also included in this study as the control group (n=50).

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Mirandola, Leonardo, Maurizio Chiriva-Internati, Everardo Cobos, et al. "Chemokine receptors as novel targets of the oncogene Notch1 in acute lymphoblastic leukemia." Journal of Clinical Oncology 31, no. 15_suppl (2013): 7060. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.7060.

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7060 Background: Malignant cells from different cancers express different profiles of chemokine receptors (CKR). Their presence may influence site-specific spread of tumor cells, by enabling them to respond to chemokine gradient, and may increase cell sensibility to chemokine mediated proliferative and anti-apoptotic stimuli. Notch ability to positively regulate CKR has been reported: stimulation of Pax5-/- pre-B cells with the Notch ligand Delta-1 results in induction of transcripts for CCR4, CCR8 and CXCR 6; the Delta-1-dependent regulation of Langerhans cell development includes induction o

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Parween, Farhat, Noshin Kathuria, Hongwei Zhang, and Joshua M. Farber. "CCR2 mediates transendothelial migration of human pathogenic Th17 cells." Journal of Immunology 202, no. 1_Supplement (2019): 117.23. http://dx.doi.org/10.4049/jimmunol.202.supp.117.23.

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Abstract Leukocyte extravasation is characterized by rolling and arrest on the endothelium followed by transendothelial migration (TEM). Leukocyte arrest and TEM typically require chemokines and their receptors. Previously, we showed that CD4+CCR5+CCR2+ T cells are highly differentiated, readily activated memory cells in human blood that exhibit diverse effector capabilities. We and others have also shown that CCR6 is the signature chemokine receptor for Th17 cells. Here we describe studies of the migratory capabilities and effector profiles of CD4+CCR6+CCR2+ as compared with CD4+CCR6+CCR2− an

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Owen, Sherry M., Dennis Ellenberger, Mark Rayfield, et al. "Genetically Divergent Strains of Human Immunodeficiency Virus Type 2 Use Multiple Coreceptors for Viral Entry." Journal of Virology 72, no. 7 (1998): 5425–32. http://dx.doi.org/10.1128/jvi.72.7.5425-5432.1998.

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ABSTRACT Several members of the seven-transmembrane chemokine receptor family have been shown to serve, with CD4, as coreceptors for entry by human immunodeficiency virus type 1 (HIV-1). While coreceptor usage by HIV-1 primary isolates has been studied by several groups, there is only limited information available concerning coreceptor usage by primary HIV-2 isolates. In this study, we have analyzed coreceptor usage of 15 primary HIV-2 isolates, using lymphocytes from a donor with nonfunctional CCR5 (CCR5 −/−; homozygous 32-bp deletion). Based on the infections of PBMCs, seven of these primary

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Lee, Benhur, Benjamin J. Doranz, Shalini Rana, et al. "Influence of the CCR2-V64I Polymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4." Journal of Virology 72, no. 9 (1998): 7450–58. http://dx.doi.org/10.1128/jvi.72.9.7450-7458.1998.

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ABSTRACT The chemokine receptors CCR5 and CXCR4 are used by human immunodeficiency virus type 1 (HIV-1) in conjunction with CD4 to infect cells. In addition, some virus strains can use alternative chemokine receptors, including CCR2b and CCR3, for infection. A polymorphism inCCR2 (CCR2-V64I) is associated with a 2- to 4-year delay in the progression to AIDS. To investigate the mechanism of this protective effect, we studied the expression of CCR2b and CCR2b-V64I, their chemokine and HIV-1 coreceptor activities, and their effects on the expression and receptor activities of the major HIV-1 core

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Ogilvie, Patricia, Giuseppe Bardi, Ian Clark-Lewis, Marco Baggiolini, and Mariagrazia Uguccioni. "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5." Blood 97, no. 7 (2001): 1920–24. http://dx.doi.org/10.1182/blood.v97.7.1920.

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Abstract Eotaxin is a potent inducer of eosinophil chemotaxis and was considered as a selective ligand of the CC chemokine receptor 3 (CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes. This study shows that eotaxin also interacts with CCR2 and CCR5 and can, thus, affect the responses of monocytes, which express both receptors. In human monocytes pretreatment with eotaxin decreased responsiveness to MCP-1, a selective ligand for CCR2, as well as to RANTES and MIP-1β, which bind to CCR5. Similar effects were obtained with transfected cells expressing CCR2 or CCR5, but her

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Simmons, Graham, Jacqueline D. Reeves, Áine McKnight, et al. "CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages." Journal of Virology 72, no. 10 (1998): 8453–57. http://dx.doi.org/10.1128/jvi.72.10.8453-8457.1998.

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ABSTRACT The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated equally well in macrophages with or without CCR5 and were inhibited by several different ligands for CXCR4 including SDF-1 and bicyclam derivative AMD3100. SI strains that used a broad range of coreceptors including CCR3, CCR5, CCR8, CXCR4, and BONZO infected CCR5-deficient macrophages about 10-fold less efficiently than CCR5+macrophages. Moreover, AMD3100 blocked infection of CCR5-negative m

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Naif, Hassan M., Shan Li, Mohammed Alali, et al. "CCR5 Expression Correlates with Susceptibility of Maturing Monocytes to Human Immunodeficiency Virus Type 1 Infection." Journal of Virology 72, no. 1 (1998): 830–36. http://dx.doi.org/10.1128/jvi.72.1.830-836.1998.

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ABSTRACT The chemokine receptor CCR5 and to a lesser extent CCR3 and CCR2b have been shown to serve as coreceptors for human immunodeficiency virus type 1 (HIV-1) entry into blood- or tissue-derived macrophages. Therefore, we examined the expression of the chemokine receptors CCR1, CCR2b, CCR3, CCR5, and CXCR4 as RNAs or as membrane-expressed antigens in monocytes maturing into macrophages and correlated these results with the susceptibility of macrophages to HIV-1 infection, as measured by their concentrations of extracellular p24 antigen and levels of intracellular HIV DNA by quantitative PC

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Yamaguchi, Mio, Kiyoshi Takagi, Koki Narita, et al. "Stromal CCL5 Promotes Breast Cancer Progression by Interacting with CCR3 in Tumor Cells." International Journal of Molecular Sciences 22, no. 4 (2021): 1918. http://dx.doi.org/10.3390/ijms22041918.

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Chemokines secreted from stromal cells have important roles for interactions with carcinoma cells and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of stromal cells and associated with tumor progression, interacting with C-C chemokine receptor (CCR) 1, 3 and 5 expressed in tumor cells. However, the expression on CCL5 and its receptors have so far not been well-examined in human breast carcinoma tissues. We therefore immunolocalized CCL5, as well as CCR1, 3 and 5, in 111 human breast carcinoma tissues and correlated them with clinicopathological

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Wei, Jin-Hua, Xiao Feng, Zhi-Jian Sun, et al. "Different locations of RANTES and its receptors on mouse epididymal spermatozoa." Reproduction, Fertility and Development 28, no. 10 (2016): 1509. http://dx.doi.org/10.1071/rd14231.

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Our previous study showed that the chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) originating from the mouse epididymis bound to the midpiece of luminal spermatozoa. The present study was undertaken to investigate the association between RANTES and epididymal spermatozoa and to determine whether the association is mediated by the RANTES receptors CCR1, CCR3 or CCR5. The use of reverse transcription polymerase chain reaction (RT-PCR), immunohistochemical staining and immunofluorescent staining demonstrated that RANTES secreted by apical and narrow cells of mou

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Hartley, Oliver, Karim Dorgham, Danielle Perez-Bercoff, et al. "Human Immunodeficiency Virus Type 1 Entry Inhibitors Selected on Living Cells from a Library of Phage Chemokines." Journal of Virology 77, no. 12 (2003): 6637–44. http://dx.doi.org/10.1128/jvi.77.12.6637-6644.2003.

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ABSTRACT The chemokine receptors CCR5 and CXCR4 are promising non-virus-encoded targets for human immunodeficiency virus (HIV) therapy. We describe a selection procedure to isolate mutant forms of RANTES (CCL5) with antiviral activity considerably in excess of that of the native chemokine. The phage-displayed library of randomly mutated and N-terminally extended variants was screened by using live CCR5-expressing cells, and two of the selected mutants, P1 and P2, were further characterized. Both were significantly more potent HIV inhibitors than RANTES, with P2 being the most active (50% inhib

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Esmailiyan, Mehrnoosh, Hadi Nobari, Mehdi Kargarfard, et al. "Effect of 12-Week Aerobic Exercise Training on Chemokine Ligands and Their Relative Receptors in Balb/C Mice with Breast Cancer." International Journal of Sport Studies for Health 5, no. 2 (2022): 28–64. http://dx.doi.org/10.61838/kman.intjssh.5.2.8.

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Background: Some chemokines like C C motif chemokine ligand (CCL) 2 and 5 and their receptors (CCR) 2 and 5 are mediators of chronic inflammation and cancer development. Moreover, physical exercise can increase the activity of antioxidant enzymes. However, its effect on cancer cells has not been reported at present. Objectives: Therefore, the present study aimed to ascertain the effect of 12-week aerobic exercise training (AET) on CCL2, CCR2, CCL5, and CCR5 in mice with breast cancer. Methods: Sixteen Balb/c mice aged 4 - 5 weeks (n = 16; approximate weight: 18 ± 2 g) were divided into two gro

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Tiffany, H. Lee, Ghalib Alkhatib, Christophe Combadiere, Edward A. Berger, and Philip M. Murphy. "CC Chemokine Receptors 1 and 3 Are Differentially Regulated by IL-5 During Maturation of Eosinophilic HL-60 Cells." Journal of Immunology 160, no. 3 (1998): 1385–92. http://dx.doi.org/10.4049/jimmunol.160.3.1385.

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Abstract CC chemokine receptors 1 and 3 (CCR1 and CCR3) are expressed by eosinophils; however, factors regulating their expression and function have not previously been defined. Here we analyze chemokine receptor expression and function during eosinophil differentiation, using the eosinophilic cell line HL-60 clone 15 as a model system. RNA for CCR1, -3, -4, and -5 was not detectable in the parental cells, and the cells did not specifically bind CC chemokines. Cells treated with butyric acid acquired eosinophil characteristics; expressed mRNA for CCR1 and CCR3, but not for CCR4 or CCR5; acquir

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Kohlmeier, Alison, Lisa Haddad, Richard Haaland, et al. "Distinct migratory phenotypes of luminal CD4 T cell subsets in the female genital tract." Journal of Immunology 196, no. 1_Supplement (2016): 136.11. http://dx.doi.org/10.4049/jimmunol.196.supp.136.11.

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Abstract The trafficking and retention of T cells in the genital mucosa provides a means of protection against many invading pathogens, yet this process is poorly understood. We measured six chemokine receptors and integrins important for T cell trafficking into peripheral sites on both resident (TRM: CCR7lo and CD69+) and recirculating (TRCM: CCR7hi CD69−) memory CD4 T cells localized at the luminal surface of the genital tract from healthy women to characterize migratory phenotypes under steady state conditions. Compared to memory CD4 T cells from blood, total memory CD4 T cells from the lum

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Segerer, Stephan, and Peter J. Nelson. "Chemokines in Renal Diseases." Scientific World JOURNAL 5 (2005): 835–44. http://dx.doi.org/10.1100/tsw.2005.105.

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The chemokines, members of a large family of chemotactic cytokines, act as directional cues for sorting inflammatory cell subsets to sites of inflammation or lymphoid microenvironments. In addition to their effects on migration, chemokines can also activate effector function in leukocytes and are involved in cell proliferation and angiogenesis. Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. In this report, we have reviewed recent developments (si

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Yi, Yanjie, Shalini Rana, Julie D. Turner, Nathan Gaddis, and Ronald G. Collman. "CXCR-4 Is Expressed by Primary Macrophages and Supports CCR5-Independent Infection by Dual-Tropic but Not T-Tropic Isolates of Human Immunodeficiency Virus Type 1." Journal of Virology 72, no. 1 (1998): 772–77. http://dx.doi.org/10.1128/jvi.72.1.772-777.1998.

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ABSTRACT Primary macrophages are infected by macrophage (M)-tropic but not T-cell line (T)-tropic human immunodeficiency virus type 1 (HIV-1) strains, and CCR5 and CXCR-4 are the principal cofactors utilized for CD4-mediated entry by M-tropic and T-tropic isolates, respectively. Macrophages from individuals homozygous for an inactivating mutation of CCR5 are resistant to prototype M-tropic strains that depend on CCR5 but are permissive for a dual-tropic isolate, 89.6, that can use both CCR5 and CXCR-4, as well as CCR2b, CCR3, and CCR8. Here we show that 89.6 entry into CCR5-deficient macrophag

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