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Dissertations / Theses on the topic 'CCRF'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Akrir, Khaled Ali Ahmed. "Cloud computing technology framework and reducing risks." Doctoral thesis, Česká zemědělská univerzita v Praze, 2015. http://www.nusl.cz/ntk/nusl-259675.

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The thesis investigates, in a qualitative way, the vectors that contribute to cloud computing risks in the areas of security, business, and compliance. The focus of this research is on the identification of risk vectors that affect cloud computing and the creation of a framework that can help IT managers in their cloud adoption process. Economic pressures on businesses are creating a demand for an alternative delivery of the model that can provide flexible payments, dramatic cuts in capital investment, and reductions in operational cost. Cloud computing is positioned to take advantage of these

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2

Danilov, Vladimir [Verfasser]. "Plasma Modification of Polydimethylsiloxane in a hydrogen CCRF low-pressure discharge / Vladimir Danilov." Greifswald : Universitätsbibliothek Greifswald, 2014. http://d-nb.info/1047137178/34.

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3

Gbankoto, Adam. "Approche multiparamétrique de l’étude des propriétés de populations cellulaires par vidéomicrofluorimétrie quantitative : application à l’étude de l’effet de xénobiotiques." Perpignan, 2008. http://www.theses.fr/2008PERP0855.

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En utilisant la vidéomicrofluorimétrie et l’analyse multiparamétrique (typologie et analyse factorielle discriminante) de paramètres cellulaires obtenus de l’analyse d’image et permettant la distribution des cellules dans les phase du cycle cellulaire, nous avons étudié la cytotoxicité et le mode d’action de cyclopeptides, les Laxaphycine A (laxa A) et Laxaphycine B (laxa B) sur des cellules lymphoblastiques humaines (CCRF-CEM) sensibles (CEM-WT), MDR classique (CEM-VLB) et MDR atypique (CEM-VM1) soumises au triple marquage de Hoechst 33342 (ADN nucléaire), Rhodamine 123 (mitochondries) et Rou

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4

Schauren, Juliana da Silveira. "Estudo dos polimorfismos CCR2-64I, CCR5-59353, CCR5-59356, CCR5-59402 e CCR5-59653 em pacientes com lúpus eritematoso sistêmico do sul do Brasil." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/78127.

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O Lúpus Eritematoso Sistêmico (LES) é uma doença autoimune inflamatória crônica que possui uma etiopatogênese complexa. Diversos fatores participam da patogênese da doença, dentre eles alterações no balanço de citocinas e quimiocinas. As quimiocinas e seus receptores são fundamentais na regulação da migração de leucócitos durante a inflamação e acredita-se que elas possam ter um papel importante na patogênese de doenças autoimunes, inclusive no LES. Diversos estudos abordaram o papel de quimiocinas e seus receptores no LES, porém, principalmente se tratando dos receptores de quimiocinas CCR5 e

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5

Sato, Wakiro. "Human Th17 Cells Are Identified as Bearing CCR2+CCR5- Phenotype." Kyoto University, 2008. http://hdl.handle.net/2433/124335.

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6

Sohy, Denis. "Etude de la dimérisation des récepteurs aux chimiokines CCR2, CCR5 et CXCR4." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210282.

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La dimérisation des récepteurs couplés aux protéines G est un nouveau concept apparu dans la littérature au cours des quelques années qui ont précédé le début de notre travail. Bien qu’il soit clairement établi que les récepteurs sont capables de former des homo et des hétérodimères, les conséquences fonctionnelles de telles interactions demeurent souvent peu claires. Dans une étude précédente, le laboratoire d’accueil a montré que les récepteurs aux chimiokines CCR2 et CCR5 forment des homo et des hétérodimères de manière constitutive et identifié une coopérativité négative de liaison de natu

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7

Longden, James. "Quantitative approaches to the study of the trafficking of CCR1 and CCR5." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437076.

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8

Zambra, Francis Maria Báo. "Influência dos genes CCR2 e CCR5 em hiperplasia e câncer de próstata." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/69706.

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A hiperplasia prostática benigna (HPB) e o câncer de próstata (CaP) são duas condições crônicas muito comuns em homens com idade avançada e têm sido relacionadas a processos inflamatórios. As quimiocinas são reconhecidas como mediadores críticos da resposta inflamatória por regular a migração das células imunológicas através da ativação de receptores de quimiocinas na superfície destas células. As quimiocinas estão relacionadas à patogênese tumoral, embora não seja claro de que modo afetam a progressão tumoral humana. O objetivo desse estudo foi investigar a associação de dois polimorfismos de

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Manin, Graziele Zenaro. "Identificação dos componentes do Sistema Imune que participam na resistência de camundongos em modelo de infecção letal por Legionella longbeachae." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-21052014-153321/.

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A doença dos legionários consiste em uma broncopneumonia severa e atípica, que acomete de 2 a 7% das pessoas infectadas com Legionella spp e que apresenta taxa de mortalidade que varia de 5 a 30%, sendo considerada uma importante causa de morbidade e mortalidade mundial. A patologia causada pela espécie L. pneumophila tem sido amplamente estudada em modelos experimentais e suas características clínicas foram extensivamente descritas. No entanto, este modelo não representa adequadamente a doença que acomete seres humanos, pois L. pneumophila não é letal aos camundongos como é para humanos. Rece

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10

Opalek, Judy Marcus. "I. Differential gene expression in human peripheral blood monocytes and alveolar macrophages II. Macrophage colony-stimulating factor is important in the development of pulmonary fibrosis." Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1075754091.

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Thesis (Ph. D.)--Ohio State University, 20043.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 115 p.; also includes graphics. Includes abstract and vita. Advisor: Clay B. Marsh, Dept.of Pathology. Includes bibliographical references (p. 102-115).

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Simonis, Christopher. "Molekulare Klonierung, stabile Transfektion und funktionelle Expression der murinen Chemokinrezeptoren Ccr2 und Ccr5." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-99950.

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12

Leach, Katie. "Pharmacological analysis of the CC chemokine receptors, CCR4 and CCR5 signalling properties and receptor-drug interactions." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427859.

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13

Baz, Ahsene. "Modulation des protéines prosomales (proteasomales) au cours de la différenciation des cellules leucémiques lymphoblastiques humaines (CCRF-CEM) induite par le phorbol-myristate-acétate (PMA) et leurs relations avec les protéines de surface et le complexe majeur d'histocompatibilité (MHC)." Montpellier 1, 1997. http://www.theses.fr/1997MON1T029.

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14

SANTOS, Erinaldo Ubirajara Damasceno dos. "Estudo de associação de polimorfismos nos genes CCR2 e CCR5 com o desenvolvimento de lesões cervicais induzidas pelo HPV." Universidade Federal Rural de Pernambuco, 2016. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4811.

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Submitted by Mario BC (mario@bc.ufrpe.br) on 2016-06-17T13:30:57Z No. of bitstreams: 1 Erinaldo Ubirajara Damasceno dos Santos.pdf: 5711027 bytes, checksum: 05684bbb6abc042b66317984510ed3df (MD5)<br>Made available in DSpace on 2016-06-17T13:30:57Z (GMT). No. of bitstreams: 1 Erinaldo Ubirajara Damasceno dos Santos.pdf: 5711027 bytes, checksum: 05684bbb6abc042b66317984510ed3df (MD5) Previous issue date: 2016-02-23<br>Cervical cancer (CC) affects about half a million women each year worldwide. The main etiological agent that can lead to the development of the CC is the human papillomavirus

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Kramp, Birgit [Verfasser]. "Establishing the interaction between the CC chemokine ligand 5 and the receptors CCR1 and CCR / Birgit Kramp." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1049557794/34.

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Hirata, Bruna Karina Banin. "Estudo de associação dos polimorfismos genéticos CCR2-V64I e CCR5-Delta32 com suscetibilidade e parâmetros clinicopatológicos do câncer de mama." Universidade Estadual de Londrina. Programa de Pós- Graduação em Patologia Experimental, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000190140.

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Entre os diversos tipos de cânceres, o de mama representa um grave problema de saúde pública correspondendo ao segundo tipo mais freqüente no mundo e o primeiro na população feminina. As células tumorais podem expressar receptores de quimiocinas, tais como o CCR2 e o CCR5, que estão implicados na progressão tumoral, podendo modular não apenas o recrutamento leucocitário, mas também a angiogênese, invasão e proliferação de células tumorais. Polimorfismos em muitos destes receptores são considerados fatores de risco para o desenvolvimento de diferentes tipos de câncer. A proposta deste estudo fo

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Joubert, Philippe. "Expression and function of chemokine receptors on airway smooth muscle cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103385.

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Asthma is a respiratory disease that affects 2.5-3 million Canadians. This condition is characterized by a Th2-driven immune response that implicates the infiltration of eosinophils and remodelling of the airways. In the last decade, airway smooth muscle cells (ASMC) have became the subject of intense research in the field of inflammatory lung diseases including asthma. It is known that ASMC respond to a wide variety of inflammatory mediators such as cytokines and chemokines. Function of ASMC in the context of asthma has extended beyond its traditional role of a structural cell. Indeed, it is

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18

Domínguez, Hernández Francisco. "Implicación de las quimoquinas IL-8, MCP-1, rantes, los receptores CXCR1, CXCR4, CCr2, CCr5 y el factor IGFBP-rP1 en la interfase materno-embrionaria." Doctoral thesis, Universitat de València, 2003. http://hdl.handle.net/10803/10135.

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La implantación embrionaria es la fijación del blastocisto al endometrio materno. El conocimiento de los factores moleculares implicados en su regulación es crucial para comprender los mecanismos que controlan la reproducción humana Las quimoquinas y sus receptores participan activamente en este proceso así como otros factores como IGFBP-rP1.Los objetivos principales de la tesis doctoral fueron los siguientes - Investigar la expresión y localización de la quimoquinas IL-8, MCP-1, RANTES y SDF-1 en el endometrio humano.- Estudiar la expresión y localización de los receptores de las quimoquinas

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19

John, Bangan. "Association Among CCR5 Genotypes, CCR5 Expression, And In Vitro HIV Infection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1365888090.

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20

Giongo, Cíntia de Oliveira. "Caracterização imunogenética de variantes dos genes CCR2, CCR5 e HLA-G como potenciais alvos para diagnóstico, prognóstico e tratamento do câncer de mama feminino esporádico e familial." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/78137.

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O câncer de mama é a neoplasia mais comum entre as mulheres. Sua etiologia é complexa, onde tanto fatores ambientais como genéticos podem contribuir para o desenvolvimento tumoral. Estima-se que 5 a 10% dos casos de carcinomas de mama sejam representados pelos carcinomas de mama familial e 90 a 95% sejam representados pelos carcinomas de mama esporádicos. Independente da etiologia, um dos principais agravantes é consequência da habilidade das células tumorais metastizar. Mutações podem levar a mudança ou perda de expressão de diferentes genes e isto possibilita que as células adquiram particul

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21

Fish, Richard James. "RANTES derivatives and CCR5." Thesis, University of York, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369362.

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22

Müller, Christine [Verfasser], and Gernot [Akademischer Betreuer] Zissel. "Charakterisierung CCR6-positiver T-Zellen." Freiburg : Universität, 2011. http://d-nb.info/1123463107/34.

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23

SANTUCCI, MARILINA BENEDETTA. "Ruolo della sfingosina 1-fosfato nella risposta immunitaria all’ infezione da mycobacterium tuberculosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2004. http://hdl.handle.net/2108/208530.

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In questa tesi è stato studiato il ruolo della sfingosina 1-fosfato (S1P) nella risposta immunitaria durante l’infezione da M. tuberculosis. La S1P è un lipide bioattivo che regola diverse funzioni biologiche cellulari. In questo contesto, è stata analizzata l’attività anti-micobatterica in cellule della linea monocito/macrofagica, THP-1 ed in una linea tumorale di cellule dell’epitelio alveolare, A549 infettate con il ceppo patogeno di M. tuberculosis H37Rv e stimolate con S1P. La crescita di M. tuberculosis è stata valutata tramite il saggio delle unità formanti colonia ed i risultati di que

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24

Arnatt, Christopher Kent. "DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/517.

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The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in order to develop potential therapeutics and probes. First, a series of novel compounds was designed by using pharmacophore-based drug design based upon known CCR5 antagonists and molecular modeling studies of the CCR5 receptor’s three-dimensional conformation. Once synthesized, these compounds were t

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Basquin, Jérôme. "Etude structurale du complexe CCR4-NOT." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ084/document.

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Le recyclage des ARN débute par un étape de déadenylation ou la queue poly (A) est enzymatiquement clivée. La deadenylation est l’étape limitante dans le processus de dégradation des ARN. In vivo la deadenylation s’effectue successivement par les complexes multi-protéiques Pan2-Pan3 et Ccr4-Not. Le complexe Ccr4-not est conservé chez les eucaryotes et considéré comme le complexe prédominant responsable de l’activité de déadenylation dans la cellule. Le complexe est compose de neuf protéines organisées autour de la protéine d’échafaudage Not1. Le complexe comprend quatre modules distincts ; le

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Maier, Corinna. "Expressionsanalyse des Chemokinrezeptors CCR6 auf Fibroblasten." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-60178.

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José, de Pessoa Saldanha Carlos. "Avaliação da mutação ccr532 do receptor da quimiocina como marcador genético-histórico na população de Triunfo Pernambuco." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/6316.

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Made available in DSpace on 2014-06-12T18:04:10Z (GMT). No. of bitstreams: 2 arquivo3738_1.pdf: 896817 bytes, checksum: 7cd3fad40aa580f879fae31cec4ad007 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008<br>O gene ccr5 codifica o receptor b-quimiocina 5 (CCR5), uma proteína transmembrânica que age como principal co-receptor para os vírus HIV-1, Variola major e para a bactéria Yersinia pestis, nos macrófagos e monócitos humanos. Uma deleção de 32 pares de bases neste gene dá origem ao alelo mutante ccr532 cuja presença, em homozigose

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Dorman, Klara [Verfasser], and Sebastian [Akademischer Betreuer] Kobold. "Kombinierte Expression von epithelial cell adhesion molecule (EpCAM)-spezifischem chimärem Antigenrezeptor mit den Chemokinrezeptoren CCR4, CCR8 und CXCR6 in der T-Zell-basierten Immuntherapie von murinen Tumormodellen / Klara Dorman ; Betreuer: Sebastian Kobold." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1232645435/34.

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Knipfer, Lisa [Verfasser], Stefan [Akademischer Betreuer] Wirtz, and Falk [Gutachter] Nimmerjahn. "The role of the C-C type chemokine receptors CCR4 and CCR8 in migration and effector function of innate lymphoid cells type 2 (ILC2s) / Lisa Knipfer ; Gutachter: Falk Nimmerjahn ; Betreuer: Stefan Wirtz." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1224356195/34.

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Barmania, Fatima. "Analysis of CCR5 diversity in the South African population." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/31127.

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Infection with the human immunodeficiency virus (HIV) constitutes a global pandemic, and South Africa forms part of the region known to house over two-thirds of HIV infected individuals worldwide. In the early stages of infection, the C-C chemokine receptor type five (CCR5) is the major HIV-1 co-receptor. The importance of this receptor in HIV infection and disease progression was recognised with the discovery of the CCR5 delta 32 (Δ32) allele. Individuals homozygous for this mutation lack functional CCR5 receptors. Consequently, they are almost completely resistant to HIV infection, while the

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Rodrigues, Erika Cruz Vicente. "Avaliação de empresas: CCR." reponame:Repositório Institucional do BNDES, 2014. https://web.bndes.gov.br/bib/jspui/handle/1408/7028.

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Valuation é o termo em inglês para o método utilizado para determinar o preço justo a ser pago por um ativo. Existem três métodos mais conhecidos para avaliação: a avaliação pelo método de fluxo de caixa descontado, avaliação relativa e avaliação por direitos contingentes (opções reais). Este trabalho é baseado na avaliação pelo método de fluxo de caixa descontado na análise da empresa CCR, uma das maiores empresas de concessão de infraestrutura do mundo. Após analisar os demonstrativos financeiros da companhia e, efetuar uma análise do panorama do setor de exploração de rodovias, serão realiz

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Duchesnes, Cecile Emmanuelle. "Molecular characterisation of the chemokine receptor CCR3." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407171.

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Martinelli, Roberta. "Molecular characterisation of the chemokine receptor CCR2." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398841.

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Bryce, Steven Alan. "Regulation of the bioavailability of CCR7 ligands." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5904/.

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The efficient functioning of the immune system is dependent on the coordinated movement and positioning of immune cells. These cells patrol the body and facilitate the clearance of pathogens, whilst maintaining self-tolerance and inducing adaptive immunity. The coordinated migration of cells into and within tissues is mediated by chemokines, a family of small chemotactic cytokines that are potent inducers of cellular movement. Chemokines and their cognate receptors have been shown to play key roles in health, and in a broad spectrum of diseases. After their secretion, chemokines can be control

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Sax, Michael John. "The CCL5-CCR5 Axis in Breast Cancer." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/365646.

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Cancer is one of the leading underlying causes of death worldwide. Despite decades of research, cancer is predicted to be the leading cause of death by the year 2020. Anti angiogenic therapies that target the key signalling molecule, vascular endothelial growth factor (VEGF) have shown promise in the treatment of some solid tumours, resulting in increased progression-free survival times in patients. However, there are several significant problems with current anti-angiogenic therapies, such as the phenomenon of resistance. Tumours can be divided into those that are intrinsically nonresponsive

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De, Poorter Cédric. "Mécanismes d'activation et interactions fonctionnelles hétérologues des récepteurs aux chimiokines." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209589.

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Mécanismes d’activation et conséquences fonctionnelles de la dimérisation des récepteurs aux chimiokines<p><p>Les chimiokines sont de petites protéines qui régulent la migration des cellules immunitaires. Elles exercent leur action en se liant à des récepteurs appartenant à la famille des récepteurs couplés aux protéines G (RCPG) dont la fonction est intimement liée à la régulation des cellules immunitaires. Notre laboratoire étudie depuis plusieurs années les relations reliant la structure et la fonction des récepteurs aux chimiokines. Ces dernières années, un nouveau concept est venu révolut

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Yamamoto, Takamasa. "Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225454.

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Castan, Laure. "De l'allergie alimentaire à l'asthme : rôle de CCR9." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT1018/document.

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Aujourd’hui, l’allergie est classée 4ème maladie mondiale en termes de morbidité par l’OMS. Les allergies et leur évolution naturelle (marche atopique) sont devenues un problème majeur de santé publique particulièrement dans les pays industrialisés. La marche atopique se manifeste par l’évolution de la dermatite atopique et/ou des allergies alimentaires chez le jeune enfant vers des allergies respiratoires comme l’asthme ou la rhinite allergique plus tard dans l’adolescence. Ce passage pourrait impliquer un chimiotactisme contrôlé par le système chimiokine/récepteurs de chimiokine. A l’aide d’

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Brasseit, Jennifer. "Mutagenese und funktionelle Charakterisierung des humanen CCR3-Rezeptors." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-61848.

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Castanheira, Fernanda Vargas e. Silva. "Papel protetor do receptor quimiotático CCR5 durante a sepse experimental." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-10012017-100344/.

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A sepse é uma resposta inflamatória sistêmica resultante da inabilidade do sistema imune em controlar uma infecção, onde a taxa de sobrevida está associada ao recrutamento de neutrófilos para o local da infecção. Tem sido demonstrado que a expressão de receptores quimiotáticos pode ser alterada durante a sepse. Neutrófilos de animais naives respondem às quimiocinas CXC, mas são irresponsivos às quimiocinas CC. Entretanto, dados do nosso laboratório mostram que a expressão de CXCR2 é reduzida na sepse, prejudicando a migração de neutrófilos para o foco da infecção. Além disso, ocorre o aparecim

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Costa, Giselle Calasans de Souza. "Investigação de mutações nos genes da CCR5 e langerina e suas associações com a infecção pelo HIV-1." reponame:Repositório Institucional da FIOCRUZ, 2012. https://www.arca.fiocruz.br/handle/icict/4243.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-07-25T20:46:06Z No. of bitstreams: 1 Giselle Calasans Investigação de mutacçoes nos genes....pdf: 17299730 bytes, checksum: b9919577a31cf080e622e852dc432578 (MD5)<br>Made available in DSpace on 2012-07-25T20:46:06Z (GMT). No. of bitstreams: 1 Giselle Calasans Investigação de mutacçoes nos genes....pdf: 17299730 bytes, checksum: b9919577a31cf080e622e852dc432578 (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>O HIV-1 é o agente etiológico da AI

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Chelli, Maurice. "Étude de l'oligomérisation du récepteur de chimiokines CCR5 : implication dans l'entrée du virus de l'immunodéficience humaine." Paris 6, 2003. http://www.theses.fr/2003PA066051.

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Frank, Sunna [Verfasser]. "Die Bedeutung der Chemokinrezeptoren CCR7 und CXCR4 sowie des CCR7-Liganden CCL21 für die Ausbreitung des duktalen Adenokarzinoms des Pankreas / Sunna Frank." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1019984872/34.

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Beaufrère, Marie. "Rôle de la dysbiose du microbiote intestinal et réponse Th17 dans les spondyloarthrites : pathogénie et causalité." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL046.

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Les spondyloarthrites (SpA) sont desrhumatismes inflammatoires chroniques fortementassociés à l'allèle HLA-B27 du complexe majeurd'histocompatibilité de classe I. La preuve du rôlepathogène du HLA-B27 a été apportée par plusieurslignées de rats transgéniques pour le HLA-B27 et lab2 microglobuline humaine (rats B27). Ces rats B27développent spontanément des manifestationscomparables à la SpA humaine. Dans ce modèle, lescellules hématopoïétiques HLA-B27+, leslymphocytes T CD4+ et un microbiote conventionnelsont nécessaires pour développer la maladie. Le rôledu microbiote a également été étayé pa

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Durkin, Kesta. "The role of CCR4 and CRTI-I2 in asthma." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484851.

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Chemokine receptors CCR4 and CRTH2, both expressed preferentially on Th2 cells, have been proposed to play an important role in the recruitment of T cells in asthma. The aim of this thesis was to see if fu.rther evidence of the role of CCR4 and its ligands CCLl7 and CCL22 in allergic asthma could be obtained in a combination of descriptive and functional studies. Differences in the expression ofCCR4 and CRTH2 on peripheral blood T cells from healthy non-atopic subjects and mild atopic asthmatic patients were looked for. Also the expression of a selection of activation/memory markers on CD4+ T

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Wendt, Emily Rose. "The role of CCL25 and CCR9 in intestinal inflammation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c8413dcb-4861-4afd-ae13-5cb88935e54d.

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Leukocyte extravasation is mediated in part by tissue specific chemotactic cytokines (chemokines) and specific chemokine receptors expressed on the surface of circulating cells. C-C chemokine ligand CCL25 is expressed exclusively in the intestine and thymus and mediates chemotaxis by cells expressing receptor CCR9. This chemokine and receptor pair may be relevant in the pathogenesis of intestinal inflammation, in diseases such as Crohn’s disease (CD) and coeliac disease. In this thesis I investigated CCR9 expression in situ, in tissues affected by intestinal inflammation, and also examined the

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Bonfá, Giuliano. "Papel de CCR5 na infecção oral por Toxoplasma gondii." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-08072010-152818/.

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Toxoplasma gondii é um protozoário intracelular obrigatório que causa a toxoplasmose. Em modelo experimental, camundongos C57BL/6 infectados por via oral com 100 cistos de T. gondii, cepa ME-49, desenvolvem sérias lesões intestinais similares as observadas em doenças inflamatórias intestinais. Ao invadir as células epiteliais intestinais, o parasito induz uma resposta inflamatória de padrão T helper (Th) 1 elevada, ativada pela produção de quimiocinas e citocinas envolvidas na migração e ativação celular. Para que ocorra essa migração celular para o sítio de infecção é necessário a presença de

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Horgan, Carmel M. T. "Studies on Mitozolomide (CCRG 81010), a new antineoplastic agent." Thesis, Aston University, 1985. http://publications.aston.ac.uk/12474/.

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Viney, Jonathan Mark. "Characterisation of antagonist binding sites on chemokine receptor CCR4." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11128.

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CCR4 is a chemokine receptor notably expressed on T helper 2 and regulatory T cells. CCR4 binds the chemokines CCL17 and CCL22. These are involved in T cell homeostasis and inflammatory diseases including asthma and atopic dermatitis, making CCR4 a potential therapeutic target. Previous studies suggested that CCL22 is dominant over CCL17 with respect to ligand-induced internalisation and desensitisation of CCR4. The biology of CCR4 was investigated in this project using point mutational studies. A C-terminal lysine within the conserved helix VIII region was determined to be dispensable for CCL

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Cronshaw, Darran G. "An investigation into CCR4 T lymphocyte signalling and chemotaxis." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401291.

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