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Journal articles on the topic 'CCRF'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Korbecki, Jan, Klaudyna Kojder, Katarzyna Barczak, et al. "Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review." International Journal of Molecular Sciences 21, no. 16 (2020): 5647. http://dx.doi.org/10.3390/ijms21165647.

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Hypoxia, i.e., oxygen deficiency condition, is one of the most important factors promoting the growth of tumors. Since its effect on the chemokine system is crucial in understanding the changes in the recruitment of cells to a tumor niche, in this review we have gathered all the available data about the impact of hypoxia on β chemokines. In the introduction, we present the chronic (continuous, non-interrupted) and cycling (intermittent, transient) hypoxia together with the mechanisms of activation of hypoxia inducible factors (HIF-1 and HIF-2) and NF-κB. Then we describe the effect of hypoxia

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Kim, Chang H., Jeeho Lee, and Seung G. Kang. "Developmental and antigen-driven switches in the trafficking receptors of FoxP3+ regulatory T cells (99.2)." Journal of Immunology 178, no. 1_Supplement (2007): S194. http://dx.doi.org/10.4049/jimmunol.178.supp.99.2.

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Abstract FoxP3+ regulatory T cells play important roles in immune regulation and tolerance. There is an increasing body of evidence that the migration ability of FoxP3+ T cells is important for their regulatory functions at effector tissue sites. We investigated the two different trafficking receptor switches of FoxP3+ T cells occurring in the thymus and secondary lymphoid tissues. The first trafficking receptor switch in the thymus is developmentally programmed: Precursors of FoxP3+ cells undergo the first trafficking receptor switch from CCR8/CCR9 to CXCR4 and then finally to CCR7, generatin

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Wenzl, Kerstin, Katharina Troppan, Alexander JA Deutsch, Werner Linkesch, Peter Neumeister, and Christine Beham-Schmid. "Distinct Chemokine Receptor Profile In Chronic Lymphocytic Leukaemia and Richter Transformed Diffuse Large B Cell Lymphomas Compared To Germinal Center B Cells and De Novo Diffuse Large B Cell Lymphomas." Blood 122, no. 21 (2013): 4852. http://dx.doi.org/10.1182/blood.v122.21.4852.4852.

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Abstract Chemokine receptors are G-protein-coupled cell surface receptors, which dissociate upon activation by their ligands and cause downstream signaling. Recently, several studies have revealed the crucial contribution of chemokine receptors and their ligands in normal B-cell differentiation and development of hematopoietic malignancies. The Richter syndrome (RS) represents the clinico-pathologic transformation of chronic lymphocytic leukaemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). Due to the lack of knowledge on the chemokine receptors in RS,

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Zhang, Yi-jun, Tatjana Dragic, Yunzhen Cao, et al. "Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro." Journal of Virology 72, no. 11 (1998): 9337–44. http://dx.doi.org/10.1128/jvi.72.11.9337-9344.1998.

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ABSTRACT We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal

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Yoon, Sunjoo, Ju Hyun Lee, Minsu Kang, et al. "Abstract 5951: The correlation between single nucleotide polymorphism of chemokine receptor and ligand and infiltrating immune cells on tumor microenvironment of gastric cancer." Cancer Research 83, no. 7_Supplement (2023): 5951. http://dx.doi.org/10.1158/1538-7445.am2023-5951.

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Abstract Objective: Chemokines play roles in many normal biological processes, such as hematopoietic cell genesis and leukocyte migration and homing. Chemokines could be responsible for eliciting local accumulation of immune cells within tumor microenvironment. In this study, we examine if genetic variations in chemokine receptor and ligand are associated with infiltrations of immune cells on tumor microenvironment in gastric cancer. Methods: In 356 gastric cancer patients who received curative surgery followed by adjuvant chemotherapy, total 105 single nucleotide polymorphisms (SNP) in a chem

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Chu, Yuan-Tung, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, and Wan-Chung Hu. "Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological Pathways." Biomedicines 11, no. 9 (2023): 2384. http://dx.doi.org/10.3390/biomedicines11092384.

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A comprehensive framework has been established for understanding immunological pathways, which can be categorized into eradicated and tolerable immune responses. Toll-like receptors (TLRs) are associated with specific immune responses. TH1 immunity is related to TLR7, TLR8, and TLR9, while TH2 immunity is associated with TLR1, TLR2, and TLR6. TH22 immunity is linked to TLR2, TLR4, and TLR5, and THαβ (Tr1) immunity is related to TLR3, TLR7, and TLR9. The chemokine receptor CXCR5 is a marker of follicular helper T cells, and other chemokine receptors can also be classified within a framework bas

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Kim, Chang H., Brent Johnston та Eugene C. Butcher. "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+Vβ11+ NKT cell subsets with distinct cytokine-producing capacity". Blood 100, № 1 (2002): 11–16. http://dx.doi.org/10.1182/blood-2001-12-0196.

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Abstract Natural killer T (NKT) cells are important regulators of the immune system, but their trafficking machinery, including expression of chemokine receptors, has been poorly defined. Unlike other conventional T-cell populations, we show that most NKT cells express receptors for extralymphoid tissue or inflammation-related chemokines (CCR2, CCR5, and CXCR3), while few NKT cells express lymphoid tissue–homing chemokine receptors (CCR7 and CXCR5). A population with homing potential for lymph nodes (L selectin+ CCR7+) exists only within a small subset of CD4 NKT cells. We show differential ex

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Mazur, Grzegorz, Emilia Jaskula, Ilona Kryczek, et al. "Gene Expression for Chemokine Receptors Influences Survival of Non-Hodgkin Lymphoma Patients." Blood 116, no. 21 (2010): 3103. http://dx.doi.org/10.1182/blood.v116.21.3103.3103.

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Abstract Abstract 3103 Non-Hodgkin's lymphoma (nHL) represent heterogenous group of lymphoid malignancies derived from B and T lymphocytes, NK cells or histiocytes. Most of lymphomas are B-cell origin. Lymphoma cells can migrate to other organs and their migration could be linked to chemokines and their receptors. Chemokine receptors are expressed by many cell populations, including lymphoid cells, and their main function is lymphocytes. Chemokine receptors guide lymphocytes homing, chemotaxis, adhesion and interplaying between immunologic system response cells. They are also responsible for c

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Ren, Han-Yun, Meng Wang, Xiang-Juan Ma, Yu-Jun Dong, Zhi-Xiang Qiu, and Wei Liu. "Differential Regulation Of Chemokine Receptor Expressions On T Lymphocyte Subsets In Healthy Donors After Mobilization With Rhg-CSF and Its Correlation With Acute GvHD." Blood 122, no. 21 (2013): 3296. http://dx.doi.org/10.1182/blood.v122.21.3296.3296.

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Abstract Introduction This study is aimed to investigate chemokine receptors (CCR5, CCR6, CCR7, CCR9, CXCR3 and CCR2) expression on T cell subsets in healthy donors after mobilization with recombinant human granulocyte colony-stimulating factor (rhG-CSF) and analyze its correlation with acute graft-versus-host disease (aGVHD) and to understand the possible mechanisms underlying rhG-CSF-induced immune tolerance. Methods Sixty-eight healthy donor and their recipient pairs of family donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) were included in this study. The expressions o

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Stenstad, Hanna, Anna Ericsson, Bengt Johansson-Lindbom, et al. "Gut-associated lymphoid tissue–primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine." Blood 107, no. 9 (2006): 3447–54. http://dx.doi.org/10.1182/blood-2005-07-2860.

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CD4+ T-cell entry to the intestinal mucosa is central to the generation of mucosal immunity as well as chronic intestinal inflammation, yet the mechanisms regulating this process remain poorly defined. Here we show that murine small intestinal CD4+ lamina propria lymphocytes express a heterogeneous but restricted array of chemokine receptors including CCR5, CCR6, CCR9, CXCR3, and CXCR6. CD4+ T-cell receptor transgenic OT-II cells activated in mesenteric lymph nodes acquired a distinct chemokine receptor profile, including expression of CCR6, CCR9, and CXCR3 that was only partially reproduced i

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Ortega Moreno, L., S. Fernández Tomé, M. Chaparro, et al. "P045 Profiling of human circulating dendritic cells and monocytes subsets discriminates type and mucosal status in patients with inflammatory bowel disease." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S155—S156. http://dx.doi.org/10.1093/ecco-jcc/jjz203.174.

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Abstract Background Intestinal dendritic cells (DCs) and macrophages govern the mechanisms of immune homeostasis having a role in inflammatory bowel disease (IBD) onset. However, the profile of their circulating precursors (DC and monocytes) in IBD has not been previously described in depth. Our aim was to characterise blood DC and monocyte subsets in healthy controls (HCs) and IBD patients in order to understand their potential implication in IBD pathogenesis. Methods 18 HC and 64 IBD patients were recruited. IBD patients were categorised into Crohn’s disease (CD) and ulcerative colitis (UC),

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Princen, Katrien, Sigrid Hatse, Kurt Vermeire, et al. "Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist." Journal of Virology 78, no. 23 (2004): 12996–3006. http://dx.doi.org/10.1128/jvi.78.23.12996-13006.2004.

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ABSTRACT Here we report that the N-pyridinylmethyl cyclam analog AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2 (50% inhibitory concentration [IC50] ranging from 1.2 to 26.5 μM) in various T-cell lines, CCR5- or CXCR4-transfected cells, peripheral blood mononuclear cells (PBMCs), and monocytes/macrophages. AMD3451 also inhibited R5, R5/X4, and X4 HIV-1 primary clinical isolates in PBMCs (IC50, 1.8 to 7.3 μM). A PCR-based viral entry assay revealed that AMD3451 blocks R5 and X4 HIV-1 infection at the vi

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Uhl, Barbara, Katharina T. Prochazka, Katrin Pansy, et al. "Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter’s Trans-Formed DLBCL and Germinal Center B-Cells." International Journal of Molecular Sciences 23, no. 14 (2022): 7874. http://dx.doi.org/10.3390/ijms23147874.

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Chemokine receptors and their ligands have been identified as playing an important role in the development of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, and Richter syndrome (RS). Our aim was to investigate the different expression profiles in de novo DLBCL, transformed follicular lymphoma (tFL), and RS. Here, we profiled the mRNA expression levels of 18 chemokine receptors (CCR1–CCR9, CXCR1–CXCR7, CX3CR1 and XCR1) using RQ-PCR, as well as immunohistochemistry of seven chemokine receptors (CCR1, CCR4–CCR8 and CXCR2) in RS, de novo DLBCL, and tFL biopsy-derived tissues. Tonsil-

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Zvejniece, Laura, Svetlana Kozireva, Zanna Rudevica, et al. "Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2." International Journal of Molecular Sciences 23, no. 7 (2022): 3434. http://dx.doi.org/10.3390/ijms23073434.

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Chemokines and their receptors regulate the migration of immune cells and the dissemination of cancer cells. CCR1, CCR2, CCR3, and CCR5 all belong to a single protein homology cluster and respond to the same inflammatory chemokines. We previously reported that CCR1 and CCR2B are induced upon Epstein-Barr virus (EBV) infection of B cells in vitro. EBV is present in almost all cases of endemic Burkitt lymphoma (BL); however, the contribution of EBV in the pathogenesis of the disease is not fully understood. Here, we analyzed the relation of the expression of CCR1, CCR2, CCR3, and CCR5, the EBV D

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15

Taylor, James R., Katherine C. Kimbrell, Robert Scoggins, Marie Delaney, Lijun Wu, and David Camerini. "Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1." Journal of Virology 75, no. 18 (2001): 8752–60. http://dx.doi.org/10.1128/jvi.75.18.8752-8760.2001.

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ABSTRACT The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We assayed the expression and function of the major HIV-1 coreceptors, CCR5 and CXCR4, as well as CCR4 and CCR7 as controls, on human thymocytes. We detected CCR5 on 2.5% of thymocytes, CXCR4 on 53% of the cells, and CCR4 on 16% and CCR7 on 11% of human thymocytes. Moreover,

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ANDERS, HANS-JOACHIM, VOLKER VIELHAUER, MATTHIAS KRETZLER, et al. "Chemokine and Chemokine Receptor Expression during Initiation and Resolution of Immune Complex Glomerulonephritis." Journal of the American Society of Nephrology 12, no. 5 (2001): 919–31. http://dx.doi.org/10.1681/asn.v125919.

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Abstract. Chemokines participate in leukocyte infiltration, which plays a major role in glomerular injury during immune complex glomerulonephritis (IC-GN). Because target cell expression of chemokine receptors (CCR) is thought to mediate leukocyte migration, the expression pattern of chemokines and CCR in a model of IC-GN was examined. The transient course and predominant glomerular pathology of this model allows the examination of both the induction and resolution phases of IC-GN. GN was induced in mice by daily apoferritin injection for 2 wk. Urine samples and kidneys were obtained at 1, 2,

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Clark, D. J., J. Catusse, A. Stacey, P. Borrow, and U. A. Gompels. "Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide." Journal of General Virology 94, no. 7 (2013): 1624–35. http://dx.doi.org/10.1099/vir.0.050153-0.

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Human monocytes expressing CCR2 with CD14 and CD16 can mediate antigen presentation, and promote inflammation, brain infiltration and immunosenescence. Recently identified roles are in human immunodeficiency virus infection, tuberculosis and parasitic disease. Human herpesvirus 6B (HHV-6B) encodes a chemokine, U83B, which is monospecific for CCR2, and is distinct from the related HHV-6A U83A, which activates CCR1, CCR4, CCR5, CCR6 and CCR8 on immune effector cells and dendritic cells. These differences could alter leukocyte-subset recruitment for latent/lytic replication and associated neuroin

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Sallusto, Federica, Danielle Lenig, Charles R. Mackay, and Antonio Lanzavecchia. "Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes." Journal of Experimental Medicine 187, no. 6 (1998): 875–83. http://dx.doi.org/10.1084/jem.187.6.875.

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Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional subsets of T cells, chemokine receptor expression was analyzed using monoclonal antibodies, RNase protection assays, and the response to distinct chemokines. Naive T cells expressed only CXC chemokine receptor (CXCR)4, whereas the majority of memory/activated T cells expressed CXCR3, and a small proportion expressed CC chemokine receptor (CCR)3 and CCR5. When polarized T cell lines were analyzed, CXCR3 was found to be ex

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Catusse, Julie, Chris M. Parry, David R. Dewin, and Ursula A. Gompels. "Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization." Blood 109, no. 9 (2007): 3633–39. http://dx.doi.org/10.1182/blood-2006-08-042622.

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AbstractHIV-1 strains use C-C-chemokine receptor 5, CCR5, as a coreceptor for host transmission. Human CCR5 chemokine ligands inhibit binding and infection, whereas CCR5 mutations also inhibit infection by preventing surface expression, resulting in delayed progression to AIDS. Here, we describe a human herpesvirus 6 (HHV-6A) chemokine, U83A, which binds CCR5 with higher affinity than human chemokines, displacing their binding and leading to inhibition of chemotaxis of human leukocytes. Similarly, U83A inhibits infection by HIV-1 strains which use CCR5, but not the CXCR4, coreceptor. Unlike hu

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Dragan, Paulina, Matthew Merski, Szymon Wiśniewski, Swapnil Ganesh Sanmukh, and Dorota Latek. "Chemokine Receptors—Structure-Based Virtual Screening Assisted by Machine Learning." Pharmaceutics 15, no. 2 (2023): 516. http://dx.doi.org/10.3390/pharmaceutics15020516.

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Chemokines modulate the immune response by regulating the migration of immune cells. They are also known to participate in such processes as cell–cell adhesion, allograft rejection, and angiogenesis. Chemokines interact with two different subfamilies of G protein-coupled receptors: conventional chemokine receptors and atypical chemokine receptors. Here, we focused on the former one which has been linked to many inflammatory diseases, including: multiple sclerosis, asthma, nephritis, and rheumatoid arthritis. Available crystal and cryo-EM structures and homology models of six chemokine receptor

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Mirandola, Leonardo, Maurizio Chiriva-Internati, Everardo Cobos, et al. "Chemokine receptors as novel targets of the oncogene Notch1 in acute lymphoblastic leukemia." Journal of Clinical Oncology 31, no. 15_suppl (2013): 7060. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.7060.

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7060 Background: Malignant cells from different cancers express different profiles of chemokine receptors (CKR). Their presence may influence site-specific spread of tumor cells, by enabling them to respond to chemokine gradient, and may increase cell sensibility to chemokine mediated proliferative and anti-apoptotic stimuli. Notch ability to positively regulate CKR has been reported: stimulation of Pax5-/- pre-B cells with the Notch ligand Delta-1 results in induction of transcripts for CCR4, CCR8 and CXCR 6; the Delta-1-dependent regulation of Langerhans cell development includes induction o

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Deutsch, Alexander J. A., Ariane Aigelsreiter, Elisabeth Steinbauer, et al. "Chemokine Receptor Expression Profile in the Model of Parotid MALT Lymphomagenesis: De Novo Expression of CXCR6." Blood 110, no. 11 (2007): 2622. http://dx.doi.org/10.1182/blood.v110.11.2622.2622.

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Abstract Chemokine receptors mediate migration and activation of lymphocytes through binding of their ligands. Several recent studies have revealed important contributions of chemokine receptors and their ligands to the development and progression/dissemination of hematopoietic neoplasms. Strong expression of CXCR5 and its ligand BCA-1 was detected in transformed B cells in H. pylori positive gastric MALT lymphoma. Because the knowledge of chemokine receptor expression in parotid MALT lymphoma is limited, we performed a comprehensive study on tissue samples of parotid glands (P), parotid gland

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Zilio, Serena, Silvio Bicciato, Donald Weed, and Paolo Serafini. "CCR1 and CCR5 mediate cancer-induced myelopoiesis and differentiation of myeloid cells in the tumor." Journal for ImmunoTherapy of Cancer 10, no. 1 (2022): e003131. http://dx.doi.org/10.1136/jitc-2021-003131.

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BackgroundCancer-induced ‘emergency’ myelopoiesis plays a key role in tumor progression by inducing the accumulation of myeloid cells with a suppressive phenotype peripherally and in the tumor. Chemokine receptors (CCRs) and, in particular, CCR1, CCR2, CCR5, and CCR7 are emerging as key regulators of myeloid cell trafficking and function but their precise role has not been completely clarified yet because of the signal redundancy, integration, and promiscuity of chemokines and of the expression of these CCRs on other leukocyte subsets.MethodsWe used the 4PD nanoparticle for the in vivo targete

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Tiffany, H. Lee, Ghalib Alkhatib, Christophe Combadiere, Edward A. Berger, and Philip M. Murphy. "CC Chemokine Receptors 1 and 3 Are Differentially Regulated by IL-5 During Maturation of Eosinophilic HL-60 Cells." Journal of Immunology 160, no. 3 (1998): 1385–92. http://dx.doi.org/10.4049/jimmunol.160.3.1385.

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Abstract CC chemokine receptors 1 and 3 (CCR1 and CCR3) are expressed by eosinophils; however, factors regulating their expression and function have not previously been defined. Here we analyze chemokine receptor expression and function during eosinophil differentiation, using the eosinophilic cell line HL-60 clone 15 as a model system. RNA for CCR1, -3, -4, and -5 was not detectable in the parental cells, and the cells did not specifically bind CC chemokines. Cells treated with butyric acid acquired eosinophil characteristics; expressed mRNA for CCR1 and CCR3, but not for CCR4 or CCR5; acquir

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Purbarani, Sumarsih C., Hadaiq R. Sanabila, Ari Wibisono, Noverina Alfiany, Hanif A. Wisesa, and Wisnu Jatmiko. "Distance-To-Mean Continuous Conditional Random Fields: Case Study in Traffic Congestion." Information 10, no. 12 (2019): 382. http://dx.doi.org/10.3390/info10120382.

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Traffic prediction techniques are classified as having parametric, non-parametric, and a combination of parametric and non-parametric characteristics. The extreme learning machine (ELM) is a non-parametric technique that is commonly used to enhance traffic prediction problems. In this study, a modified probability approach, continuous conditional random fields (CCRF), is proposed and implemented with the ELM and then utilized to assess highway traffic data. The modification is conducted to improve the performance of non-parametric techniques, in this case, the ELM method. This proposed method

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Paula Costa, Guilherme de, Laís Roquete Lopes, Maria Cláudia da Silva, et al. "Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from ChronicTrypanosoma cruzi-Infected Dogs." Mediators of Inflammation 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3694714.

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Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by theTrypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac tissue. Thirty mongrel dogs were infected, or not, with the Berenice-78 strain ofT. cruziand grouped according their treatments: (i) two months after infection, Dox (50 mg/kg) 2x/day for 12 months; (ii) nine months after infection, Bz (3,5 mg/kg) 2x/day for 60 days; (iii) Dox + Bz;

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Rodriguez, Alondra, Cesar I. Cardona, Colin A. Bill, and Charlotte M. Vines. "Abstract 2823: Development of an in vitro blood-brain barrier model of CCR7/CCL19 induced invasion of the central nervous system." Cancer Research 84, no. 6_Supplement (2024): 2823. http://dx.doi.org/10.1158/1538-7445.am2024-2823.

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Abstract Pediatric T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological malignancy, is characterized by abnormal thymocyte proliferation, frequently with mutations of the Notch-1 gene and has an overall 10-year survival rate of ~27%. A marker of poor prognosis is the presence of T-ALL within the central nervous system (CNS), which is treated with intrathecal chemotherapy and cranial irradiation; two toxic treatments with high morbidities. Gene-expression profiling of Notch-1-induced adhesion regulators showed that C-C chemokine receptor 7 (CCR7) was highly expressed and was

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Fantuzzi, Laura, Paola Borghi, Veniero Ciolli, George Pavlakis, Filippo Belardelli, and Sandra Gessani. "Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response." Blood 94, no. 3 (1999): 875–83. http://dx.doi.org/10.1182/blood.v94.3.875.415k28_875_883.

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Human peripheral blood monocytes differentiate into macrophages when cultured in vitro for a few days. In the present study, we investigated the expression of C-C chemokine and CXCR4 receptors in monocytes at different stages of differentiation. Culturing of monocytes for 7 days resulted in a progressive decrease of the mRNA that encodes for CCR2 and CCR3, whereas the expression of mRNA for other chemokine receptors (CCR1, CCR4, CCR5, and CXCR4) was not substantially affected. The loss of CCR2 mRNA expression in 7-day–cultured macrophages was associated with a strong reduction in the receptor

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Clemetson, Kenneth J., Jeannine M. Clemetson, Amanda E. I. Proudfoot, Christine A. Power, Marco Baggiolini, and Timothy N. C. Wells. "Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets." Blood 96, no. 13 (2000): 4046–54. http://dx.doi.org/10.1182/blood.v96.13.4046.

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Abstract Platelets are known to contain platelet factor 4 and β-thromboglobulin, α-chemokines containing the CXC motif, but recent studies extended the range to the β-family characterized by the CC motif, including RANTES and Gro-α. There is also evidence for expression of chemokine receptors CCR4 and CXCR4 in platelets. This study shows that platelets have functional CCR1, CCR3, CCR4, and CXCR4 chemokine receptors. Polymerase chain reaction detected chemokine receptor messenger RNA in platelet RNA. CCR1, CCR3, and especially CCR4 gave strong signals; CXCR1 and CXCR4 were weakly positive. Flow

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Clemetson, Kenneth J., Jeannine M. Clemetson, Amanda E. I. Proudfoot, Christine A. Power, Marco Baggiolini, and Timothy N. C. Wells. "Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets." Blood 96, no. 13 (2000): 4046–54. http://dx.doi.org/10.1182/blood.v96.13.4046.h8004046_4046_4054.

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Platelets are known to contain platelet factor 4 and β-thromboglobulin, α-chemokines containing the CXC motif, but recent studies extended the range to the β-family characterized by the CC motif, including RANTES and Gro-α. There is also evidence for expression of chemokine receptors CCR4 and CXCR4 in platelets. This study shows that platelets have functional CCR1, CCR3, CCR4, and CXCR4 chemokine receptors. Polymerase chain reaction detected chemokine receptor messenger RNA in platelet RNA. CCR1, CCR3, and especially CCR4 gave strong signals; CXCR1 and CXCR4 were weakly positive. Flow cytometr

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Clark, Thomas M., Timothy K. Hayes, and Klaus W. Beyenbach. "Dose-dependent effects of CRF-like diuretic peptide on transcellular and paracellular transport pathways." American Journal of Physiology-Renal Physiology 274, no. 5 (1998): F834—F840. http://dx.doi.org/10.1152/ajprenal.1998.274.5.f834.

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The mechanism of action of synthetic Culexcorticotropin-releasing factor (CRF)-like diuretic peptide (CCRF-DP) was investigated in isolated, perfused Malpighian tubules of the yellow fever mosquito, Aedes aegypti. Low concentrations of CCRF-DP (10−10 and 10−9 M) caused depolarizing oscillations of the lumen-positive transepithelial voltage ( V t) in Malpighian tubules, whereas high concentrations (10−8 and 10−7 M) first depolarized and then transiently hyperpolarized V t; CCRF-DP always lowered transepithelial resistance ( R t), regardless of voltage depolarization or hyperpolarization. The sh

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Wang, Meng, Han-Yun Ren, Yu-Jun Dong, et al. "Association Of Chemokine Receptor CCR5, CCR6 and CCR7 Expressions On T Lymphocyte Subsets In Recipients After Allo-HSCT With Acute GvHD." Blood 122, no. 21 (2013): 4596. http://dx.doi.org/10.1182/blood.v122.21.4596.4596.

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Introduction To study the correlation of chemokine receptors expression on T lymphocyte subsets in recipients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with acute graft-versus-host disease (acute GVHD). Methods Forty-four recipients of family donor allogeneic hematopoietic stem cell transplantation were included in this study. According to the severity of acute GVHD, the recipients were divided into Grade II-IV acute GVHD group (n=16) and Grade 0-I acute GVHD group (n=28). Additionally,fifty healthy donors were also included in this study as the control group (n=50).

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BANAS, BERNHARD, BRUNO LUCKOW, MARCUS MÖLLER, et al. "Chemokine and Chemokine Receptor Expression in a Novel Human Mesangial Cell Line." Journal of the American Society of Nephrology 10, no. 11 (1999): 2314–22. http://dx.doi.org/10.1681/asn.v10112314.

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Abstract. Chemokines are thought to play a pivotal role in mediating the selective migration of leukocytes into sites of tissue injury. The local production of chemokines by mesangial cells (MC) has been linked to inflammatory processes within the glomerulus. To study the chemokine biology of human MC, an immortalized human MC line was generated and then chemokine and chemokine receptor expression was examined in response to various proinflammatory stimuli. The results show that human MC have a specific and limited repertoire of chemokine expression. The stimulus-specific regulation of the che

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Penton-Rol, Giselle, Nadia Polentarutti, Walter Luini та ін. "Selective Inhibition of Expression of the Chemokine Receptor CCR2 in Human Monocytes by IFN-γ". Journal of Immunology 160, № 8 (1998): 3869–73. http://dx.doi.org/10.4049/jimmunol.160.8.3869.

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Abstract IFN-γ is a potent activator of mononuclear phagocyte function and promotes the development of Th1 responses. Moreover, it induces and modulates chemokine production in a variety of cell types, including mononuclear phagocytes. In the present study, we examined the effect of IFN-γ on the expression of CC chemokine receptors in human monocytes. IFN-γ selectively and rapidly inhibited expression of the monocyte chemotactic protein (MCP) receptor CCR2 with an ED50 of ∼50 U/ml. The effect was rapid (detectable after 1 h) and reversible. Other chemokine receptors (CCR1, CCR3, CCR4, and CCR5

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Yonan, Andre, Christopher Jacques, Thanaphorn Feinberg, Tafaswa Fletcher, and Robert Campbell. "Abstract 306: Selective targeting of pediatric acute lymphoblastic leukemia using CCRF-CEM CLENs: Development and characterization." Cancer Research 82, no. 12_Supplement (2022): 306. http://dx.doi.org/10.1158/1538-7445.am2022-306.

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Abstract Background: Acute lymphoblastic leukemia (ALL) is a hematological malignancy commonly observed in children under 14 years old. A defect in the hematopoietic pathway results in the uncontrolled proliferation of B-cell and T-cell lymphocyte precursors. Treatments for ALL are patient-specific and are determined based on prognostic factors such as age, minimal residue disease, and genetic alterations. Nano-sized liposomes are drug-delivery vehicles used to enhance the delivery of drugs to target cells. The composition, size, and overall charge of nanoliposomes are determinants of targetin

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Sand, Kristoffer E., Astrid Olsnes Kittang, and Øystein Bruserud. "Circulating T Cells Derived From Patients with Low Risk Myelodysplastic Syndromes Show Altered Chemokine Receptor Expression." Blood 116, no. 21 (2010): 4018. http://dx.doi.org/10.1182/blood.v116.21.4018.4018.

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Abstract Abstract 4018 Several T cell abnormalities have been described in myelodysplastic syndromes (MDS), and such abnormalities may become important for identification of patients who will benefit from T cell targeting immunosuppressive treatment. Chemokine receptor repertoires are important in the regulation of both T cell migration and function and may therefore be important in the development of MDS. Materials and Methods: The chemokine receptor expression by circulating T cells were investigated by multicolor flow cytometry for patients with newly diagnosed low risk MDS (N=16) and for h

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Gomes, Juliana A. S., Lilian M. G. Bahia-Oliveira, Manoel Otávio C. Rocha, et al. "Type 1 Chemokine Receptor Expression in Chagas' Disease Correlates with Morbidity in Cardiac Patients." Infection and Immunity 73, no. 12 (2005): 7960–66. http://dx.doi.org/10.1128/iai.73.12.7960-7966.2005.

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ABSTRACT Chemokines and chemokine receptors (CKRs) control the migration of leukocytes during the inflammatory process and are important immunological markers of type 1 (CCR5 and CXCR3) and type 2 (CCR3 and CCR4) responses. The coexpression of CKRs (CCR2, CCR3, CCR5, CXCR3, and CXCR4) and intracellular cytokines (interleukin-10 [IL-10], IL-4, tumor necrosis factor alpha [TNF-α], and gamma interferon [IFN-γ]) on T CD4+ and CD8+ peripheral cells from individuals with indeterminate (IND) or cardiac (CARD) clinical forms of Chagas' disease after in vitro stimulation with Trypanosoma cruzi antigens

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Clark, T. M., T. K. Hayes, G. M. Holman, and K. W. Beyenbach. "The concentration-dependence of CRF-like diuretic peptide: mechanisms of action." Journal of Experimental Biology 201, no. 11 (1998): 1753–62. http://dx.doi.org/10.1242/jeb.201.11.1753.

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The mechanism of action of synthetic CCRF-DP, the corticotropin-releasing factor (CRF)-related diuretic peptide of the salt marsh mosquito Culex salinarius, was investigated in isolated Malpighian tubules of the yellow fever mosquito Aedes aegypti. A low concentration of CCRF-DP (10(-9)mol l-1) caused a small but insignificant increase in transepithelial secretion of NaCl and fluid, but significantly reduced transepithelial voltage and resistance without a change in short-circuit current, pointing to the stimulation of passive Cl- transport through the paracellular pathway as the principal mec

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Tian, C., L. Liu, M. Zheng, Z. Ye, R. Chen, and Xiang Lan. "MiR-503 Contributes to Glucocorticoid Sensitivity in Acute Lymphoblastic Leukaemia via Targeting WNT3A." Folia Biologica 67, no. 5-6 (2021): 199–207. http://dx.doi.org/10.14712/fb2021067050199.

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Abnormal accumulation of lymphoblasts in the blood and bone marrow is the main characteristic of acute lymphoblastic leukaemia (ALL). Glucocorticoids are effective drugs for ALL, while glucocorticoid resistance is an obstacle to ALL therapy. MicroRNAs (miRNAs) are implicated in the drug resistance and modulate the response of ALL to glucocorticoids. The role of miR-503 in glucocorticoid sensitivity of ALL was investigated in this study. Firstly, T-leukaemic cells were isolated from patients with ALL. The human ALL cell line (CCRF/CEM) was incubated with dexamethasone to establish a glucocortic

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Bartko, Ewa A., Lars H. Blom, Jesper Elberling, Lars K. Poulsen, and Bettina M. Jensen. "Expression of CCR8 and CCX-CKR on Basophils in Chronic Urticaria Is Amplified by IgE-Mediated Activation." Biomedicines 11, no. 6 (2023): 1537. http://dx.doi.org/10.3390/biomedicines11061537.

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Recruitment to the local tissue and alerted phenotype are the hallmarks of basophils in chronic urticaria (CU). Chemokine receptors such as chemokine (C-C motif) receptor 4 (CCR4) or CCR8 have been studied in skin diseases, e.g., atopic dermatitis, but not in CU. In this study, we aimed to define CU’s basophil homing potential and receptor profile and the effect of Omalizumab treatment on these. Unstimulated and activated (anti-IgE, fMLP, C5a, and Substance P) whole blood basophils from 11 Omalizumab-treated CU patients and 10 healthy subjects were investigated with flow cytometry. Unstimulate

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Korbecki, Jan, Szymon Grochans, Izabela Gutowska, Katarzyna Barczak, and Irena Baranowska-Bosiacka. "CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands." International Journal of Molecular Sciences 21, no. 20 (2020): 7619. http://dx.doi.org/10.3390/ijms21207619.

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CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system cells, such as CD4+ and CD8+ lymphocytes, dendritic cells, eosinophils, macrophages, monocytes, and NK cells, as well in neoplasia. In this review, we discuss human CC motif chemokine ligands: CCL1, CCL3, CCL4, CCL5, CCL18, CCL19, CCL20, CCL21, CCL25, CCL27, and CCL28 (CC motif chemokine receptor CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands). We present their functioning in human physiology and in neoplasia, including their role in the proliferation, apoptos

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Pawlik, Katarzyna, and Joanna Mika. "Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain." Molecules 28, no. 15 (2023): 5766. http://dx.doi.org/10.3390/molecules28155766.

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Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients’ quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and ma

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Davies, Faith E., Mona H. Al Rayes, J. Anthony Child, Gareth J. Morgan, and Andrew C. Rawstron. "The Bone Marrow Microenvironment Influences the Differential Chemokine Receptor Expression of Normal and Neoplastic Plasma Cells." Blood 104, no. 11 (2004): 2353. http://dx.doi.org/10.1182/blood.v104.11.2353.2353.

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Abstract The expression of cytokines and chemokines are under control of several factors, including the bone marrow (BM) microenvironment. The aim of this work was to study the chemokine receptor expression on normal and neoplastic PCs and to investigate the relationship between the BM microenvironment and plasma cell behaviour. The study included 20 patients with reactive disorders or normal BM, 20 individuals with MGUS (monoclonal gammopathy of undetermined significance) and 19 patients with multiple myeloma at presentation. A large panel of chemokine receptor-specific antibodies directed ag

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Parween, Farhat, Noshin Kathuria, Hongwei Zhang, and Joshua M. Farber. "CCR2 mediates transendothelial migration of human pathogenic Th17 cells." Journal of Immunology 202, no. 1_Supplement (2019): 117.23. http://dx.doi.org/10.4049/jimmunol.202.supp.117.23.

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Abstract Leukocyte extravasation is characterized by rolling and arrest on the endothelium followed by transendothelial migration (TEM). Leukocyte arrest and TEM typically require chemokines and their receptors. Previously, we showed that CD4+CCR5+CCR2+ T cells are highly differentiated, readily activated memory cells in human blood that exhibit diverse effector capabilities. We and others have also shown that CCR6 is the signature chemokine receptor for Th17 cells. Here we describe studies of the migratory capabilities and effector profiles of CD4+CCR6+CCR2+ as compared with CD4+CCR6+CCR2− an

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Lamare, Maxim L., John D. Hedley, and Martin D. King. "The effects of surface roughness on the calculated, spectral, conical–conical reflectance factor as an alternative to the bidirectional reflectance distribution function of bare sea ice." Cryosphere 17, no. 2 (2023): 737–51. http://dx.doi.org/10.5194/tc-17-737-2023.

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Abstract. The conical–conical reflectance factor (CCRF) has been calculated as an alternative to the bidirectional reflectance distribution function (BRDF) for three types of bare sea ice with varying surface roughness (σ= 0.1–10) and ice thicknesses (50–2000 cm) over an incident solar irradiance wavelength range of 300–1400 nm. The comprehensive study of the CCRF of sea ice presented here is paramount for interpreting sea ice measurements from satellite imagery and inter-calibrating space-borne sensors that derive albedo from multiple multi-angular measurements. The calculations performed by

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Soto-Rodriguez, Guadalupe, Juan-Antonio Gonzalez-Barrios, Daniel Martinez-Fong, et al. "Analysis of Chemokines and Receptors Expression Profile in the Myelin MutantTaiepRat." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/397310.

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Taieprat has a failure in myelination and remyelination processes leading to a state of hypomyelination throughout its life. Chemokines, which are known to play a role in inflammation, are also involved in the remyelination process. We aimed to demonstrate that remyelination-stimulating factors are altered in the brainstem of 1- and 6-month-oldtaieprats. We used a Rat RT2Profiler PCR Array to assess mRNA expression of 84 genes coding for cytokines, chemokines, and their receptors. We also evaluated protein levels of CCL2, CCR1, CCR2, CCL5, CCR5, CCR8, CXCL1, CXCR2, CXCR4, FGF2, and VEGFA by EL

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Pramesthy, Tyas Dita, Ratu Sari Mardiah, Shiffa F. Shalichaty, et al. "ANALISIS ALAT TANGKAP JARING INSANG (GILL NET) BERDASARKAN KODE ETIK TATALAKSANA PERIKANAN BERTANGGUNG JAWAB DI PERAIRAN KOTA DUMAI." Aurelia Journal 1, no. 2 (2020): 103. http://dx.doi.org/10.15578/aj.v1i2.8951.

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. Pengembangan perikanan tangkap berbasis CCRF dapat dilakukan untuk memanfaatkan potensi perikanan tangkap secara optimal. Penelitian ini dilakukan untuk menganalisis alat tangkap jaring insang berdasarkan dokumen CCRF sebagai kelanjutan dalam memberikan kebijakan dalam penggunaan alat tangkap. Metode pengambilan data yaitu menggunakan kuesioner selanjutnya dianalisis menggunakan statistika deskriptif. Hasil penelitian menunjukkan kekurangan dari penggunaan jaring insang yaitu terdapat pada mutu ikan yang tertangkap cenderung sedikit mengalami cacat fisik (bagian operkulum), serta masih terta

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Mubarok, Hamba Ainul, Sugeng Hari Wisudo, and Budhi Hascaryo Iskandar. "STATUS PERIKANAN PANAH DI KEPULAUAN KARIMUNJAWA KABUPATEN JEPARA JAWA TENGAH BERDASARKAN CCRF (CCRF Perspective on Spearfisheries in Karimunjawa Islands, Jepara District Central Java)." Marine Fisheries : Journal of Marine Fisheries Technology and Management 3, no. 2 (2016): 155. http://dx.doi.org/10.29244/jmf.3.2.155-122.

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<p>ABSTRACT<br />Speargun is productive fishing gear,spearfishermen catch numerous reef fishes such as yellow tail, snapper grouper,andother fish species.Spearfishermen dive to spear fishes. Air supply diving is common in spearfishing, therefore spearfishermen facing a huge health risk. Diving safety standard should be applied by spearfishermen to prevent various diving diseases.Research objectives wereto determine the Karimunjawa spearfishing status by the CCRF perspective and describe job safety analysis.Fishing gear used by fishermen consists of a gun made of wood with a rubber

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Bryson, Michelle S., Ruth F. Jarrett, Lesley Sheild, and Gerard J. Graham. "Constitutive Chemokine Receptor Expression in B-Cell Non-Hodgkin’s Lymphoma." Blood 110, no. 11 (2007): 3590. http://dx.doi.org/10.1182/blood.v110.11.3590.3590.

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Abstract Chemokines are small peptides (∼8-14KDa) that play an essential role in both the innate and adaptive immune system. Chemokines are primarily involved in leukocyte trafficking, but are also involved in a number of cellular mechanisms. They elicit their effect through G-protein coupled receptors, the chemokine receptors (CKR). Functionally chemokines and their receptors are classified as inflammatory or constitutive. Constitutive CKRs and their ligands have a role in numerous diseases including malignancy, chronic inflammation and HIV infection. This study aimed to examine constitutive

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González-Arriagada, Wilfredo A., Carlos Lozano-Burgos, Rodrigo Zúñiga-Moreta, Paulina González-Díaz, and Ricardo D. Coletta. "Clinicopathological significance of chemokine receptor (CCR1, CCR3, CCR4, CCR5, CCR7 and CXCR4) expression in head and neck squamous cell carcinomas." Journal of Oral Pathology & Medicine 47, no. 8 (2018): 755–63. http://dx.doi.org/10.1111/jop.12736.

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