Relevant bibliographies by topics / CCSVI

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'CCSVI'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "CCSVI"

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Amato, MP, V. Saia, B. Hakiki, M. Giannini, L. Pastò, S. Zecchino, S. Lori, E. Portaccio, and M. Marinoni. "No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis." Multiple Sclerosis Journal 18, no. 12 (April 18, 2012): 1791–96. http://dx.doi.org/10.1177/1352458512445943.

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Objective: Chronic cerebrospinal venous insufficiency (CCSVI) was hypothesized to play a causative role in multiple sclerosis (MS). The assessment of pediatric-onset MS (POMS) may provide a unique window of opportunity to study hypothesized risk factors in close temporal association with the onset of the disease. Methods: Internal jugular veins, vertebral veins and intracranial veins were evaluated with extracranial and intracranial ultrasound in 15 POMS and 16 healthy controls. Assessor’s blinding was maintained during the study. We considered subjects positive to CCSVI when at least two criteria were fulfilled. Results: CCSVI frequency was comparable between POMS and controls ( p > 0.05). Clinical features were not significantly different between CCSVI-positive and CCSVI-negative patients. Conclusions: Our findings add to previous data pointing against a causative role of CCSVI in MS.
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Metz, Luanne M., Jamie Greenfield, Ruth Ann Marrie, Nathalie Jette, Gregg Blevins, Lawrence W. Svenson, Katayoun Alikhani, Winona Wall, Raveena Dhaliwal, and Oksana Suchowersky. "Medical Tourism for CCSVI Procedures in People with Multiple Sclerosis: An Observational Study." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 43, no. 3 (February 4, 2016): 360–67. http://dx.doi.org/10.1017/cjn.2015.350.

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AbstractBackground: Many Canadians with multiple sclerosis (MS) have recently travelled internationally to have procedures for a putative condition called chronic cerebrospinal venous insufficiency (CCSVI). Here, we describe where and when they went and describe the baseline characteristics of persons with MS who participated in this non–evidence-based medical tourism for CCSVI procedures. Methods: We conducted a longitudinal observational study that used online questionnaires to collect patient-reported information about the safety, experiences, and outcomes following procedures for CCSVI. A convenience sample of all Albertans with MS was recruited between July 2011 and March 2013. Results: In total, 868 individuals enrolled; 704 were included in this cross-sectional, baseline analysis. Of these, 128 (18.2%) participants retrospectively reported having procedures for CCSVI between April 2010 and September 2012. The proportion of participants reporting CCSVI procedures declined from 80 (62.5%) in 2010, to 40 (31.1%) in 2011, and 8 (6.3%) in 2012. In multivariable logistic regression analysis, CCSVI procedures were independently associated with longer disease duration, secondary progressive clinical course, and greater disability status. Conclusions: Although all types of people with MS pursued procedures for CCSVI, a major driver of participation was greater disability. This highlights that those with the greatest disability are the most vulnerable to unproven experimental procedures. Participation in CCSVI procedures waned over time possibly reflecting unmet expectations of treated patients, decreased media attention, or that individuals who wanted procedures had them soon after the CCSVI hypothesis was widely publicized.
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Van Den Berg, P. J., and L. H. Visser. "Extra- and Transcranial Echo Colour Doppler in the Diagnosis of Chronic Cerebrospinal Venous Insufficiency." Phlebology: The Journal of Venous Disease 27, no. 1_suppl (March 2012): 107–13. http://dx.doi.org/10.1258/phleb.2011.012s04.

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A new venous disorder, chronic cerebrospinal venous insufficiency (CCSVI), has been proposed in patients with multiple sclerosis (MS). It is a vascular condition characterized by an impaired cerebrospinal venous drainage due to obstructions in the main extracranial cerebrovenous outflow routes (i.e. internal jugular veins [IJV] and/or azygos veins). In this review, the studies which assessed the prevalence of CCSVI in MS by echo colour Doppler (ECD) will be discussed. The technical aspects of determination of the five CCSVI criteria: (1) reflux in the IJV and/or vertebral veins in supine and upright position, (2) reflux in the deep cerebral veins, (3) high-resolution B-mode proximal IJV stenosis, (4) flow not Doppler detectable in IJVs and/or vertebral veins (VVs) and (5) reverted postural control of the main cerebrovenous outflow pathway are described in detail. We conclude that so far there are many studies with contradictory results, and as yet a strong scientific base to support the evidence for a causative relationship of CCSVI and MS is lacking. Recent studies call into question the validity of using ECD as a proper and reliable test for the diagnosis of CCSVI. One explanation for the variety in interpretation of the individual CCSVI criteria, with the wide-ranging percentages CCSVI, could be the different methods by using ECD to determine various criteria.
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Comi, G., MA Battaglia, A. Bertolotto, M. Del Sette, A. Ghezzi, G. Malferrari, M. Salvetti, et al. "Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study." Multiple Sclerosis Journal 19, no. 11 (September 6, 2013): 1508–17. http://dx.doi.org/10.1177/1352458513501231.

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Background: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). Objectives: The CoSMo study evaluated the association between CCSVI and MS. Methods: The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. Results: The study involved 35 MS centers across Italy and included 1874 subjects aged 18–55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72–3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53–4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47–2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers. Conclusions: CCSVI is not associated with MS.
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Leone, Maurizio A., Olga Raymkulova, Piergiorgio Lochner, Laura Bolamperti, Gianandrea Rivadossi, Alessandro Stecco, Giuseppe Zaccala, et al. "Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case–control study." Phlebology: The Journal of Venous Disease 30, no. 10 (July 31, 2014): 736–38. http://dx.doi.org/10.1177/0268355514544782.

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Objectives To evaluate the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and the presence of a Chronic Venous Disorder (CVD). Method We included 55 subjects with CCSVI aged >18 years, and 186 controls without CCSVI. Each subject was evaluated with color Doppler sonography in accordance with Zamboni’s five criteria, examined by two neurologists and interviewed with an ad-hoc designed form. The neurologists and the sonographers were mutually blinded. CVD were classified according to CEAP. Results Mean age was 42 years (SD = 9) in cases and 43 years (10) in controls ( p = ns). The odds ratios in subjects CCSVI were 0.6 (0.2–2.2) for CEAP 1, 0.9 (0.2–4.5) for CEAP 2, and 1.0 (0.6–1.9) for family history of varicose veins. The prevalence of CVD and, family history of varicose veins, was similar between cases and controls for each Zamboni criterion. Conclusions We found no association of CCSVI with the presence of CVD or family history of varicose veins.
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Valdueza, José M., Florian Doepp, Stephan J. Schreiber, Bob W. van Oosten, Klaus Schmierer, Friedemann Paul, and Mike P. Wattjes. "What Went Wrong? the Flawed Concept of Cerebrospinal Venous Insufficiency." Journal of Cerebral Blood Flow & Metabolism 33, no. 5 (February 27, 2013): 657–68. http://dx.doi.org/10.1038/jcbfm.2013.31.

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In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the central nervous system is associated with multiple sclerosis (MS), coining the term of chronic cerebrospinal venous insufficiency (‘CCSVI’). The diagnosis of ‘CCSVI’ is based on sonographic criteria, which he found exclusively fulfilled in MS. The concept proposes that chronic venous outflow failure is associated with venous reflux and congestion and leads to iron deposition, thereby inducing neuroinflammation and degeneration. The revival of this concept has generated major interest in media and patient groups, mainly driven by the hope that endovascular treatment of ‘CCSVI’ could alleviate MS. Many investigators tried to replicate Zamboni's results with duplex sonography, magnetic resonance imaging, and catheter angiography. The data obtained here do generally not support the ‘CCSVI’ concept. Moreover, there are no methodologically adequate studies to prove or disprove beneficial effects of endovascular treatment in MS. This review not only gives a comprehensive overview of the methodological flaws and pathophysiologic implausibility of the ‘CCSVI’ concept, but also summarizes the multimodality diagnostic validation studies and open-label trials of endovascular treatment. In our view, there is currently no basis to diagnose or treat ‘CCSVI’ in the care of MS patients, outside of the setting of scientific research.
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Thapar, A., T. Lane, R. Nicholas, T. Friede, M. Ellis, J. Assenheim, I. J. Franklin, and A. H. Davies. "Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis." Phlebology: The Journal of Venous Disease 26, no. 8 (October 23, 2011): 319–25. http://dx.doi.org/10.1258/phleb.2011.011098.

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Objective The sonographic findings of chronic cerebrospinal venous insufficiency (CCSVI) are used by some as selection criteria for venography. We performed a systematic review to establish the prevalence and strength of association between sonographic CCSVI and multiple sclerosis (MS). Method Two reviewers searched PubMed and EMBASE from 1948 to date using the keywords ‘chronic cerebrospinal venous insufficiency’ according to PRISMA guidelines. Results Four cross-sectional studies met the criteria for inclusion. The prevalence of CCSVI ranged from 7% to 100% in MS patients and from 2% to 36% in healthy controls. Diagnostic odds ratios for MS varied between 2 and 26, 499 ( I 2 = 94%). Sensitivities of CCSVI for MS varied between 7% and 100% ( I 2 = 98%). Specificities varied between 64% and 100% ( I 2 = 95%). Conclusion There is substantial variation in the strength of association between CCSVI and MS beyond that explained by demographic differences or sonographer training. Reliable evidence on which to base decisions requires sonographic consensus and assessment of the reproducibility of individual criteria between trained sonographers.
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Lugli, M., M. Morelli, S. Guerzoni, and O. Maleti. "The Hypothesis of Pathophysiological Correlation between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis: Rationale of Treatment." Phlebology: The Journal of Venous Disease 27, no. 1_suppl (March 2012): 178–86. http://dx.doi.org/10.1258/phleb.2012.012s24.

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Background: The possible role of the venous system in the pathogenesis of chronic neurodegenerative diseases has been hypothesized for decades. Quite recently, the description of a venous condition defined as chronic cerebrospinal venous insufficiency (CCSVI) and its strong association with multiple sclerosis (MS) has brought back the attention of the scientific community to the hypothesis of an aetiological or concomitant role of an altered venous function in the occurrence of this pathology. CCSVI is identified by sonographic criteria, thus the indication for its possible treatment is based on ultrasound findings. Method: We retrospectively examined 167 consecutive patients affected by clinically defined MS and CCSVI, identified by ultrasound assessment by the presence of at least two sonographic criteria. Ultrasonographic diagnosis of CCSVI was then integrated by venography and intravascular ultrasound examination (in 43 patients). Patients were all submitted to endovascular procedure (venoplasty). Results In 37% of cases there was no correspondence between the preoperative ultrasound assessment and the venographic findings. In the event of incongruity between venography and sonography, the intravascular ultrasound examination investigation, when performed, confirmed ultrasound findings in 42% of cases and venography results in 58%. At one month in 12% of cases ultrasound assessment showed the persistence of altered flux. In 67% of cases patients reported subjective amelioration, regarding non-specific symptoms. Conclusion: The pathophysiology of CCSVI is yet to be defined. The superior cava venous system is highly complex in terms of anatomy and possible anomalies, as well as its haemodynamic mechanisms. Further studies are required to define the parameters of diagnosis and treatment of CCSVI.
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Thapar, A., T. R. A. Lane, V. Pandey, J. Shalhoub, O. Malik, M. Ellis, I. J. Franklin, R. Nicholas, and A. H. Davies. "Internal jugular thrombosis post venoplasty for chronic cerebrospinal venous insufficiency." Phlebology: The Journal of Venous Disease 26, no. 6 (July 29, 2011): 254–56. http://dx.doi.org/10.1258/phleb.2011.011052.

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Chronic cerebrospinal venous insufficiency (CCSVI) is a hypothesis through which cerebral venous drainage abnormalities contribute towards the pathogenesis of multiple sclerosis. CCSVI venoplasty is already practised worldwide. We report the case of a 33-year-old lady with multiple sclerosis who underwent left internal jugular venoplasty resulting in iatrogenic jugular thrombosis requiring open thrombectomy for symptom relief. This occurred without insertion of a stent and while fully anticoagulated. Clinicians should be aware that endovenous treatment of CCSVI could cause paradoxical deterioration of cerebral venous drainage. Patients with complications post venoplasty are now presenting to geographically distant vascular units.
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Beggs, C., S. Shepherd, and P. Zamboni. "Cerebral venous outflow resistance and interpretation of cervical plethysmography data with respect to the diagnosis of chronic cerebrospinal venous insufficiency." Phlebology: The Journal of Venous Disease 29, no. 3 (October 11, 2012): 191–99. http://dx.doi.org/10.1258/phleb.2012.012039.

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Objective: While chronic cerebrospinal venous insufficiency (CCSVI) can be characterized using cervical plethysmography, much remains unknown about the haemodynamics associated with this procedure. The aim of the study was therefore to gain a deeper understanding of the observed haemodynamics. Method: Forty healthy controls and 44 CCSVI patients underwent cervical plethysmography, which involved placing a strain-gauge collar around their necks and tipping them from the upright (90°) to supine position (0°) in a chair. Once stabilized, they were returned to the upright position, allowing blood to drain from the neck. A mathematical model was used to calculate the hydraulic resistance of the extracranial venous system for each subject in the study. Results: The mean hydraulic resistance of the extracranial venous system was 10.28 (standard deviation [SD] 5.14) mmHg.s/mL in the healthy controls and 16.81 (SD 9.22) in the CCSVI patients ( P < 0.001). Conclusions: The haemodynamics of the extracranial venous system are greatly altered in CCSVI patients.
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Dissertations / Theses on the topic "CCSVI"

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BARTOLOMEI, Ilaria. "Modificazioni fisiopatologiche e cliniche indotte a livello del Sistema Nervoso Centrale dall'Insufficienza Venosa Cerebrospinale Cronica (CCSVI)." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388749.

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BACKGROUND – The description of a new syndrome, the Chronic Cerebrospinal Venous Insufficiency (CCSVI), led us to investigate the relationship between the venous system and Central Nervous System (CNS). In particular, in the last years we have focused on the relationship between CCSVI and Multiple Sclerosis (MS). OBJECTIVES - To evaluate the clinical and pathophysiological changes induced by CCSVI in the CNS, particularly how this syndrome causes iron deposition in the brain parenchyma, the alteration of MRI perfusion, the CSF outflow obstruction and the immune system activation that generates demyelinating lesions. MATERIALS AND METHODS - 102 MS patients (46 RR, 30 SP, 26 PP), and 30 subjects with CNS involvement non MS (15 affected by CIS, 7 people with evidence of RIS, 4 patients with Arnold- Chiari Syndrome and 4 with chronic headache) underwent a combined transcranial and extracranial EchoColorDoppler high-resolution examination (TCCS-ECD) aimed at detecting the prevalence of CCSVI and correlate the venous system involvement with the clinical findings. CCSVI is defined by the presence of at least two out of five parameters of anomalous venous outflow described by Zamboni. Finally we studied the possible correlations between the different hemodynamic patterns and the symptoms of the onset of MS and clinical course; we evaluated the long term clinical outcome of patients with relapsing-remitting MS after PTA treatment. RESULTS -According to the TCCS-ECD criteria, CCSVI is present in 97% of MS patients, in 73% of CIS, in 71% of RIS and even if the cohort is too small to be representative, in 100% of Arnold-Chiari and in 75% of headaches. CCSVI is a syndrome characterized by headache that appears or worse in supine position, sleep disorders, cognitive dysfunctions, chronic fatigue and memory disorders. In a few patients we found extrapyramidal syndrome and normal pressure hydrocephalus. CONCLUSION - MS is strongly associated with CCSVI; endovascular treatment is effective on neurological signs and symptoms of MS although multicenter, double-blind, clinical trial with a larger number of patients will be necessary to confirm this data. Venous neurovascular team is necessary to the care of patients with MS and for better understanding the pathogenesis of MS.
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Tavoni, Valentina. "Clinical applicability of an US model to calculate the head blood outflow through collateral vessels." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8333/.

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Le vene giugulari interne sembrano essere la via principale attraverso cui il sangue defluisce dal cervello verso il cuore, quando siamo in posizione supina. Nel 2008 il professor Paolo Zamboni ha scoperto che una diminuzione dell'attività giugulare può portare allo sviluppo di una condizione emodinamica chiamata CCSVI. Questa può causare ipossia, ritardi nella perfusione cerebrale e riduzione del drenaggio dei cataboliti, oltre ad un'attivazione infiammatoria delle piccole vene e dei tessuti vicini. Questa condizione è stata da subito associata alla sclerosi multipla e su questo argomento si sono dibattuti molti gruppi di ricerca. Inoltre, altre patologie sembrano essere associate alla CCSVI, come il morbo di Parkinson, l'Alzheimer e la sindrome di Meniere. Proprio quest'ultima è uno degli argomenti che attualmente interessa di più il gruppo di lavoro in cui mi sono inserita. Questa patologia comporta problemi uditivi, come sordità e tinnito, vertigini e nausea. Il gruppo Vascolar Disease Center (VDC) dell'Università di Ferrara ha previsto per l'anno 2015 uno studio multicentrico, in cui si cercherà di verificare la correlazione tra CCSVI e sindrome di Meniere. La mia tesi fa parte di un studio preliminare a quello multicentrico. All'inizio del lavoro mi sono dedicata ad un'analisi critica di un modello emodinamico per la quantificazione dei flussi sanguigni: il modello BMC, pubblicato nel 2013 dal gruppo VDC, effettuando in parallelo una ricerca bibliografica sullo stato dell'arte in materia. In seguito ho cominciato a studiare off-line diversi studi patologici e fisiologici, in modo da prendere confidenza con gli strumenti e con le metodologie da utilizzare. Sono stata poi coinvolta dal gruppo VDC per partecipare attivamente al miglioramento del protocollo legato al modello BMC. Infine ho analizzato, con due metodologie differenti, 35 studi effettuati su pazienti otorinolaringoiatrici. Con i risultati ottenuti ho potuto effettuare diverse analisi statistiche al fine di verificare l'equivalenza delle due metodologie. L'obiettivo ultimo era quello di stabilire quale delle due fosse la tecnica migliore da utilizzare, successivamente, nello studio multicentrico.
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MENEGATTI, Erica. "FISIOPATOLOGIA ED EMODINAMICA DELL’INSUFFICIENZA VENOSA CRONICA CEREBROSPINALE." Doctoral thesis, Università degli studi di Ferrara, 2010. http://hdl.handle.net/11392/2389173.

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According to the physic principles regulating the cerebrospinal venous drainage, a list of haemdoynamic parameters has been created and aimed to the sonographic evaluation of such venous district. All these values demonstrated to be physiology-related, easily reproducible and detectable by means of a new trans and extra-cranial echo-color Doppler protocol (ECD-TCCS) of evaluation. This assessment has been tested on 60 healthy volunteers. Experimental Part I: The extracranial venous outflow routes in clinically defined multiple sclerosis (CDMS) have not previously been investigated. Sixty-five patients affected by CDMS, and 235 controls composed, respectively, of healthy subjects, healthy subjects older than CDMS patients, patients affected by other neurological diseases and older controls not affected by neurological diseases but scheduled for venography (HAV-C) blindly underwent to ECD-TCCS aimed to detecting at least two of five parameters of anomalous venous outflow. According to the ECD-TCCS screening, patients and HAV-C further underwent selective venography of the azygous and jugular venous system with venous pressure measurement. CDMS and ECD-TCCS venous outflow anomalies were dramatically associated (OR 43, 95% CI 29 to 65, p<0.0001). Subsequently, venography demonstrated in CDMS, and not in controls, the presence of multiple severe extracranial stenosis, affecting the principal cerebrospinal venous segments; this provides a picture of chronic cerebrospinal venous insufficiency (CCSVI) with four different patterns of distribution of stenosis and substitute circle. CDMS is strongly associated with CCSVI, a scenario that has not previously been described, characterized by abnormal venous haemodynamics determined by extracranial multiple venous strictures of unknown origin. The location of venous obstructions plays a key role in determining the clinical course of the disease Experimental Part II: It has been hypothesized the presence of the relationship between a Doppler cerebral venous hemodynamic insufficiency severity score (VHISS) and cerebrospinal fluid (CSF) flow dynamics. For this reason 16 patients presenting with CCSVI and relapsing-remitting MS (CCSVI-MS) and in eight healthy controls (HCs) were evaluated using validated echo-Doppler and advanced 3T-MRI CSF flow measures. Compared with the HCs, the CCSVI-MS patients showed a significantly lower net CSF flow (p=0.027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS.
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Santoriello, Anthony John. "Assessing Unique Core Values with the Competing Values Framework: The CCVI Technique for Guiding Organizational Culture Change." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2315.

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Extensive research suggests organizations have unique guiding principles, called core values, which play a central role in strategic decision making, sustaining high-performance cultures, and guiding organizational culture change. Although the Competing Values Framework (CVF) has been widely used to identify a standardized set of core values, it has not been used to identify unique core values at a given organizations. Unique core values help to distinguish organizations and drive market success. The present research focused on development of a technique to extend the application of the CVF to identify the core values unique to a given organization. The CVF-based Core Values Identification Technique (CCVI) was developed and empirically tested at three companies. Data collection methods included semi-structured interviews, review of documents, participant observation and the standard CVF-based Organizational Culture Assessment Instrument (OCAI). The data analysis employed grounded theory methods in conjunction with the standard OCAI analysis. The primary research result is the iteratively developed and empirically tested tool, the CCVI Technique. Secondary research results include the identification of unique core values at each of the three participating companies. Lessons learned and the rationale for making modifications to the technique based on the case studies, along with best practices for utilization and opportunities for informing organizational change efforts are discussed.
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Hensley-Pipkin, Charity. "Use of the Physical Classroom Environment as a Teaching and Learning Tool Including the Impact of the CCSSI in Kindergarten Through Third Grade Classrooms in Northeast Tennessee." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2556.

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The specific goal of this study was to determine the use of the physical classroom environment as a teaching and learning tool in an era of the implementation of the Common Core State Standards Initiative (CCSSI). This qualitative multi-case study focused on the learning principles and epistemological beliefs of primary teachers with reference to the physical classroom environment and the teaching process in regard to meeting the expectations set forth by the CCSSI. The researcher sought participation from a city school district in Northeast Tennessee which included a total of 8 participating teachers consisting of 2 each of grades kindergarten, first, second, and third. The Teacher Beliefs Survey (Woolley, Benjamin, & Woolley, 2004) was administered to determine teachers’ philosophical position regarding constructivist and traditional beliefs. Based upon responses, 8 teachers representing the most constructivist and most traditional teachers in each grade were selected for further participation. Teachers’ practices and perceptions of the role of the physical environment in the teaching and learning process including consideration of the CCSSI were further explored through interview. Each physical classroom environment was evaluated using the Primary Educators Environment Rating Scale (PEERS), a rubric designed to assess the use of the physical classroom environment on a continuum from traditional to constructivist practices (Evanshen & Faulk, under review). Observational field notes and photographs were collected in order to document environmental components of the physical classroom environment of each participant. Data was collected and triangulated through the use of the aforementioned methods. Through the data analysis process, the researcher found all participants to demonstrate support for the role of the physical environment in the teaching and learning process which was determined based on results of the interview in conjunction with findings of the PEERS and supporting photographic evidence. Each teacher’s personal experiences and philosophy of education was found to guide the physical classroom environment design and layout in various ways. While most teachers felt the CCSSI had little or no impact on their physical classroom environment, all shared in varying degrees the use of the physical environment as a tool to support students in developing 21st century skills.
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Urbas, Boris. "La communication scientifique muséale au prisme de l'action en présentiel : le cas du Pavillon des Sciences." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOL015/document.

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Dans les institutions muséales dévolues à la communication scientifique publique, la médiation dite « présentielle », plaçant en coprésence des objets, un public et un médiateur dans un environnement dédié, reste méconnue. Du point de vue des SIC, l’analyse de situations concrètes permet de dépasser le seul cadre d’une transmission d’informations, pour s’interroger sur l’importance des formes du tiers dans le contexte de construction du sens. La communication présentielle est éphémère et repose sur les paroles et les gestes d’un tiers incarné. Elle offre une plus grande potentialité d’échanges dans la situation, à la différence d’autres médias, comme l’exposition. L’objectif de cette recherche est d’interroger la place de ces spécificités dans les dispositifs de médiation du Pavillon des sciences, un Centre de Culture Scientifique, Technique et Industrielle. Menée en immersion et à partir de méthodes qualitatives (observations, entretiens), elle a permis d’observer le déroulement de situations de médiation, d’adopter le point de vue du public et celui des animateurs. Les animateurs scientifiques proposent au public des formes d’accès aux savoirs scientifiques basées sur l’articulation d’un propos et d’une mise en scène de l’approche expérimentale. Ces résultats permettent de mettre au jour une forme de communication sui generis, hybride entre médiation muséale et animation, et mettant à disposition une diversité de signifiants
In science museums and science centers, "presential" mediation positioning a mediator and the public in the co-presence of objects within a dedicated environment, remains relatively unknown. From a Communication Science perspective, analyzing actual situations transcends the simple provision of information, and focuses on the significance of third party forms within the construction of meaning. Presential communication is transient and centered on the words and gestures of an embodied third party. It provides a greater potential for interactions around practical situations, unlike other media (i.e. an exhibition). The purpose of this research is to question the rightful place of these specificities within mediation processes in the Pavillon des Sciences, a french science center. Using qualitative methods and an immersive approach (observations, interviews), this research has enabled the analysis of mediation situations and adopted the viewpoint of both the explainers and the public. Scientific mediators propose different forms of access to scientific knowledge to the public, based on the exploration of a theme and presentation of an experimental approach. These results renew a hybrid form of sui generis communication, between museal interpretation and sociocultural activities, through the presentation of a variety of signifiers
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Beggs, Clive B. "Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis." 2013. http://hdl.handle.net/10454/9565.

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Yes
Venous abnormalities contribute to the pathophysiology of several neurological conditions. This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS), leukoaraiosis, and normal-pressure hydrocephalus (NPH). The review is supplemented with hydrodynamic analysis to assess the effects on cerebrospinal fluid (CSF) dynamics and cerebral blood flow (CBF) of venous hypertension in general, and chronic cerebrospinal venous insufficiency (CCSVI) in particular.CCSVI-like venous anomalies seem unlikely to account for reduced CBF in patients with MS, thus other mechanisms must be at work, which increase the hydraulic resistance of the cerebral vascular bed in MS. Similarly, hydrodynamic changes appear to be responsible for reduced CBF in leukoaraiosis. The hydrodynamic properties of the periventricular veins make these vessels particularly vulnerable to ischemia and plaque formation.Venous hypertension in the dural sinuses can alter intracranial compliance. Consequently, venous hypertension may change the CSF dynamics, affecting the intracranial windkessel mechanism. MS and NPH appear to share some similar characteristics, with both conditions exhibiting increased CSF pulsatility in the aqueduct of Sylvius.CCSVI appears to be a real phenomenon associated with MS, which causes venous hypertension in the dural sinuses. However, the role of CCSVI in the pathophysiology of MS remains unclear.
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8

Weibezahl, Lara. ""Man muss nicht jeder Sau hinterherrennen, die gerade mal wieder durchs Dorf getrieben wird." Wie diskutieren Patienten den Unterschied zwischen Wissenschaft und Erleben in einem Multiple-Sklerose-Online-Forum." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3ED5-F.

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Beggs, Clive B., C. R. Magnano, Simon J. Shepherd, K. Marr, V. Valnarov, D. Hojnacki, N. Bergsland, et al. "Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow." 2013. http://hdl.handle.net/10454/11801.

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yes
To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging. Materials and Methods Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ≥2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes. Results CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021). Conclusion CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals
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Doka, Yamigno Serge [Verfasser]. "Characterization of as- grown and Ge- ion implanted CuGaSe2 thin films prepared by the CCSVT technique / von Serge Doka Yamigno." 2006. http://d-nb.info/988492962/34.

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Books on the topic "CCSVI"

1

CCSVI as the cause of multiple sclerosis: The science behind the controversial theory. Jefferson, N.C: McFarland & Co., 2011.

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Devanney, Burris. Community and Civil Society (CCSI) proposal, NSGA peer health education program: Interim narrative and financial report to 31 December 2003. Serrekunda: Nova Scotia-Gambia Association, 2004.

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Devanney, Burris. Community and Civil Society (CCSI) proposal, NSGA peer health education program in The Gambia (March 2001 - December 2005): Interim narrative and financial report to 31 December 2004. Serrekunda: Nova Scotia-Gambia Association, 2004.

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British Library. The British Library catalogue of additions to the manuscripts: New series. : Additional manuscripts 63650-70637, Egerton manuscripts 3813-3867, additional charters and rolls 76609-76772, 76792-76836, Egerton charters and rolls 8853-8858, detatched seals and casts CCVI. 1-9. London: The Library, 1993.

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British Library. The British Library catalogue of additions to the manuscripts: New series. : additional manuscripts 68892-70637, Egerton manuscripts 3813-3867, additional charters and rolls 76609-76772, 76792-76836, Egerton charters and rolls 8853-8858, detatched seals and casts CCVI. 1-9. London: The Library, 1993.

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Benjaminy, Shelly, and Anthony Traboulsee. At the crossroads of civic engagement and evidence-based medicine: Lessons learned from the chronic cerebrospinal venous insufficiency experience. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198786832.003.0014.

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The field of neuroethics aims to align neurotechnologies with societal values. To achieve this goal, the field must be responsive to the priorities of diverse publics. Researchers have developed many initiatives aimed at fostering reciprocal and inclusive dialogue between neuroscientists and publics that bring the voices of end-users to the forefront of innovation in the brain sciences. This chapter explores the opportunities and challenges of community engagement in the neurosciences. It draws on the contentious case study of the chronic cerebrospinal venous insufficiency (CCSVI) research trajectory that generated both hope and skepticism, galvanized substantial international attention, and was heavily criticized for privileging scientific inquiry driven more by public pressure than by evidence. It concludes with lessons learned from the cautionary CCSVI tale, and discusses opportunities for reciprocal and impactful engagement that the field of neuroethics may foster as novel neurotechnologies are developed.
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Poetry June 2015 Volume CCVI Number 3. Poetry Foundation, 2015.

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Book chapters on the topic "CCSVI"

1

Nahler, Gerhard. "Company Core Safety Information (CCSI)." In Dictionary of Pharmaceutical Medicine, 33–34. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_249.

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Gai, Yan-tao, Fei Pei, Hua-li Cai, and Yong Su. "Toothpaste Industry Customer Satisfaction Survey Based on the CCSI Model." In Proceedings of the 22nd International Conference on Industrial Engineering and Engineering Management 2015, 941–47. Paris: Atlantis Press, 2016. http://dx.doi.org/10.2991/978-94-6239-180-2_90.

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"CCXVI." In Catalog of Syriac and Garshuni Manuscripts in the Vatican Library, 503. Piscataway, NJ, USA: Gorgias Press, 2010. http://dx.doi.org/10.31826/9781463224066-116.

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"CCLVI." In Catalog of Syriac and Garshuni Manuscripts in the Vatican Library, 545–48. Piscataway, NJ, USA: Gorgias Press, 2010. http://dx.doi.org/10.31826/9781463224066-156.

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"CCVI." In Catalog of Syriac and Garshuni Manuscripts in the Vatican Library, 493–95. Piscataway, NJ, USA: Gorgias Press, 2010. http://dx.doi.org/10.31826/9781463224066-106.

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K. Thibault, Paul. "Cerebrospinal Venous Obstruction: Anatomy, Clinical Presentation, Diagnosis, and Treatment of Chronic Infective Cerebrospinal Venulitis." In Cerebral Circulation - Updates on Models, Diagnostics and Treatments of Related Diseases [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102685.

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This review chapter describes the normal anatomy and function of the cerebrospinal venous system, ultrasound diagnosis of obstructions in the system, and the clinical implications and treatment of chronic cerebrospinal venous obstruction (CCSVO) associated with chronic persistent Chlamydophila pneumoniae (Cpn) infection. The normal patterns of flow in the cerebrospinal venous system are described and guidelines for the interpretation of the extracranial duplex ultrasound (ECDU) examination of the neck veins are presented. An infective cause of CCSVO is proposed and relevant pathology tests necessary for a diagnosis of chronic persistent Cpn venulitis are discussed. A treatment protocol for Cpn chronic venulitis is described and recommended. The progress of the patient with CCSVO can then be followed and monitored by using the ECDU and relevant pathology tests after 3 and 6 months. CCSVO is a relatively common condition encountered in chronic diseases of unknown etiology and is often neglected by medical practitioners when managing patients with symptoms of brain fog, chronic headaches, and fatigue. Objective diagnostic and treatment protocols are required to make further progress with these conditions.
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"Canadian Cancer Society Research Institute (CCSRI)." In The Grants Register 2018, 210–11. London: Palgrave Macmillan UK, 2018. http://dx.doi.org/10.1007/978-1-349-94186-5_266.

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"Canadian Cancer Society Research Institute (CCSRI)." In The Grants Register 2023, 269–70. London: Palgrave Macmillan UK, 2022. http://dx.doi.org/10.1057/978-1-349-96053-8_976.

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"Canadian Cancer Society Research Institute (CCSRI)." In The Grants Register 2020, 218. London: Palgrave Macmillan UK, 2019. http://dx.doi.org/10.1057/978-1-349-95943-3_213.

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"Canadian Cancer Society Research Institute (CCSRI)." In The Grants Register 2021, 235–36. London: Palgrave Macmillan UK, 2020. http://dx.doi.org/10.1057/978-1-349-95988-4_216.

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Conference papers on the topic "CCSVI"

1

"CCSI 2013 Reviewers." In 2013 Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2013. http://dx.doi.org/10.1109/waina.2013.308.

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"CCSI-2012 Reviewers." In 2012 IEEE Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2012. http://dx.doi.org/10.1109/waina.2012.261.

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"CCSI 2013 Organizing Committee." In 2013 Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2013. http://dx.doi.org/10.1109/waina.2013.307.

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"CCSI-2012 Organizing Committee." In 2012 IEEE Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2012. http://dx.doi.org/10.1109/waina.2012.260.

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Papastathopoulos, Evangelos, Klaus Körner, and Wolfgang Osten. "Chromatic confocal spectral interferometry (CCSI)." In SPIE Optics + Photonics. SPIE, 2006. http://dx.doi.org/10.1117/12.678713.

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"Welcome Message from CCSI-2012 Workshop Organizers." In 2012 IEEE Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2012. http://dx.doi.org/10.1109/waina.2012.259.

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"Message from CCSI 2013 Symposium Co-Chairs." In 2013 Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2013. http://dx.doi.org/10.1109/waina.2013.306.

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Lai, Jingang, Xiaoqing Lu, Antonello Monti, and Rik W. De Doncker. "Distributed Event-Driven Power Sharing Control for CCVSI-Based Distributed Generators in AC Islanded Microgrids." In 2019 IEEE Energy Conversion Congress and Exposition (ECCE). IEEE, 2019. http://dx.doi.org/10.1109/ecce.2019.8913184.

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"Table of contents." In 2012 IEEE Conference on Control, Systems & Industrial Informatics (ICCSII). IEEE, 2012. http://dx.doi.org/10.1109/ccsii.2012.6470461.

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"[Front cover]." In 2012 IEEE Conference on Control, Systems & Industrial Informatics (ICCSII). IEEE, 2012. http://dx.doi.org/10.1109/ccsii.2012.6470453.

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Reports on the topic "CCSVI"

1

Engel, David W., and Angela C. Dalton. CCSI Risk Estimation: An Application of Expert Elicitation. Office of Scientific and Technical Information (OSTI), October 2012. http://dx.doi.org/10.2172/1064598.

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Miller, David C., Madhava Syamlal, Roger Cottrell, Joel D. Kress, S. Sundaresan, Xin Sun, C. Storlie, et al. Annual Report: Carbon Capture Simulation Initiative (CCSI) (30 September 2013). Office of Scientific and Technical Information (OSTI), September 2013. http://dx.doi.org/10.2172/1122936.

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Miller, David C., Madhava Syamlal, Roger Cottrell, Joel D. Kress, Xin Sun, S. Sundaresan, Nikolaos V. Sahinidis, et al. Annual Report: Carbon Capture Simulation Initiative (CCSI) (30 September 2012). Office of Scientific and Technical Information (OSTI), September 2012. http://dx.doi.org/10.2172/1098237.

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Engel, David W., Angela C. Dalton, Chandrika Sivaramakrishnan, and Carina Lansing. CCSI Technology Readiness Levels Likelihood Model (TRL-LM) User?s Guide. Office of Scientific and Technical Information (OSTI), March 2013. http://dx.doi.org/10.2172/1083408.

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Ng, B., C. Tong, J. Ou, and J. Leek. LLNL ARRA Report on CCSI Uncertainty Quantification Capabilities with Applications on MEA Process Models. Office of Scientific and Technical Information (OSTI), February 2012. http://dx.doi.org/10.2172/1092509.

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Lawal, Adekola, Pieter Schmal, Alfredo Ramos, Alejandro Cano, Debangsu Bhattacharyya, David Mebane, Nikolaos Sahinidis, Ananya Chowdhury, Xiaohui Liu, and Stefan Bellinghausen. Evaluation and demonstration of commercialization potential of CCSI tools within gPROMS advanced simulation platform. Office of Scientific and Technical Information (OSTI), May 2017. http://dx.doi.org/10.2172/1358691.

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Santoriello, Anthony. Assessing Unique Core Values with the Competing Values Framework: The CCVI Technique for Guiding Organizational Culture Change. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2312.

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