Log in

Relevant bibliographies by topics / CD23 / Dissertations / Theses

To see the other types of publications on this topic, follow the link: CD23.

Dissertations / Theses on the topic 'CD23'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'CD23.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Shi, Jianguo. "Interaction of human CD23 with IgE and CD21." Thesis, King's College London (University of London), 1997. https://kclpure.kcl.ac.uk/portal/en/theses/interaction-of-human-cd23-with-ige-and-cd21(373685f2-b918-4cae-9404-c10d226ff134).html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Van, Zyl Dwain George. "Production of recombinant human CD21 and CD23 : towards a better understanding of their interaction." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d10211135.

Full text

Abstract:

The prevalence of allergic diseases has dramatically increased over the last three decades. Presently, it is estimated that 20-30 per cent of the developed world suffers from allergic diseases. The majority of allergic diseases are rooted in the activities of IgE; an immunoglobulin which exerts its effector functions by interacting with a network of proteins. This network includes its low affinity receptor CD23. Cross linking of membrane IgE and CD21 by soluble CD23 results in an increase in IgE synthesis. This marks the interaction between CD23 and CD21 as an attractive therapeutic target. Ho

APA, Harvard, Vancouver, ISO, and other styles

3

Karagiannis, Sophia. "The process of endocytosis of CD23." Thesis, King's College London (University of London), 1995. https://kclpure.kcl.ac.uk/portal/en/theses/the-process-of-endocytosis-of-cd23(553202e7-a9c8-444e-b0a5-f7561d1e6297).html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Yahya, Mohd Norhakim. "Analysis of the IgE network : inhibition of CD23-mediated IgE upregulation and CD21/C3d interaction." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:bc5ff165-2d2c-4e4f-a0e9-5651cacd2ddf.

Full text

Abstract:

Allergic reactions are mainly mediated by the interactions between the IgE and its ligands, amongst them CD23 and CD21 in what is termed the IgE network. CD23 is involved in upregulating IgE expression by forming a trimolecular complex with CD21 and IgE on the B-cell surface, resulting in the specific activation of IgE-positive B cells. CD21 also interacts with C3d and is a bridge between the innate and the immune system. A crystal structure of the interaction has been solved (Szakonyi et al., 2001) but was controversial because it contradicted previous biochemical analyses. The aims of this t

APA, Harvard, Vancouver, ISO, and other styles

5

Ford, Jill Wallace. "CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/2104.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Ferreira, Lauren. "Cytokine properties of CD23 on human Eosinophilic cells." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/503.

Full text

Abstract:

CD23, the low affinity IgE receptor, is expressed by various cell types and has numerous functions depending on the form of the protein, its interaction with various ligands and the type of cell involved. CD23 is pivotal in the regulation of IgE, with the soluble form involved in up-regulation, while the membrane bound form is involved in the down-regulation. It is clear why it is believed to be a central molecule in allergic responses, and a therapeutic target for the treatment of allergic disease. In this study a recombinant form of the entire extracellular domain of the protein, exCD23, was

APA, Harvard, Vancouver, ISO, and other styles

7

Grundy, Gabrielle Jane. "The structure and function of human soluble CD23." Thesis, King's College London (University of London), 2001. https://kclpure.kcl.ac.uk/portal/en/theses/the-structure-and-function-of-human-soluble-cd23(1c2f66b1-b335-4192-892f-bbbf3afde432).html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Yuan, Daopeng. "Structural studies of human CD23 and its complexes." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/structural-studies-of-human-cd23-and-its-complexes(b8946602-66b9-4b39-a02e-4cda67c1c26d).html.

Full text

Abstract:

IgE plays a central role in the pathogenesis of immediate hypersensitivity reactions through interacting with its receptors, in particular the high affinity receptor FcεRI. The low-affinity IgE receptor, CD23, affects IgE-dependent immune responses by regulating the synthesis of IgE, facilitating allergen presentation to the immune system, and influencing the activation and differentiation of B- and T-cells. Surprisingly, CD23 is different from other Ig receptors and belongs to the C-type (calcium-dependent) lectin family. Calcium binding to CD23 affects IgE binding to CD23, but previous NMR a

APA, Harvard, Vancouver, ISO, and other styles

9

Ilkow, Veronica Franciszka. "Engineering IgE antibodies and CD23 for therapeutic discovery." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/engineering-ige-antibodies-and-cd23-for-therapeutic-discovery(54f73d64-5c16-42c4-9dea-42855873eeb6).html.

Full text

Abstract:

Immunoglobulin E (IgE) is fundamental to the allergic response and the functions of IgE are mediated by its Fc region binding to two receptors, FcεRI and CD23 (FcεRII). The interaction of IgE with other proteins have complicated our investigations of the unique role each receptor plays. To solve this, a small-scale library of IgE-Fc proteins was designed with two key positions, one at each receptor-binding site mutated. The unpredictable allosteric nature of IgE prevents rational engineering approaches, thus the design of a membrane-bound IgE-Fc-GFP-tagged protein allowed for the generation of

APA, Harvard, Vancouver, ISO, and other styles

10

Bansal, Amolak Singh. "The influence of HLA DR on soluble CD23 secretion and serum soluble CD23 as a marker of immune dysregulation in human disease." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266381.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

ALLIOT, CAROL. "Formes solubles des cd23 et cd25 et hemopathies lymphoides : interet pronostique dans une serie de 40 leucemies lymphoides chroniques." Amiens, 1993. http://www.theses.fr/1993AMIEM041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Bund, Dagmar. "hTERT, CD23 und CD229 als Tumorantigene bei der B-CLL." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-145282.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Jutton, Mark Robert. "Biophysical and biological characterisation of a soluble human CD23 pigment." Thesis, King's College London (University of London), 2007. https://kclpure.kcl.ac.uk/portal/en/theses/biophysical-and-biological-characterisation-of-a-soluble-human-cd23-pigment(4a13a8ad-ea7a-4ba1-877d-ddd3811786a6).html.

Full text

Abstract:

C3-antigen complexes induce B cell proliferation and the synthesis of specific antibodies in the immune response. The mechanism is understood to involve the co-ligation of antigen receptor (lgM) and CD21 on the membrane of antigen-specific B cells. CD23 is the low-affinity IgE receptor and also binds to CD21. It has been shown by NMR spectroscopy that the binding sites for IgE and CD21 on CD23 are distinct and nonoverlapping. CD23 is expressed as a homotrimer on the membrane of B cells and is cleaved by an endogenous metalloprotease to release soluble fragments that contain the f binding sites

APA, Harvard, Vancouver, ISO, and other styles

14

Reljic, Rajko. "The interaction of CD23 and CR2 and its functional consequences." Thesis, King's College London (University of London), 1996. https://kclpure.kcl.ac.uk/portal/en/theses/the-interaction-of-cd23-and-cr2-and-its-functional-consequences(01e4a5aa-37fc-4892-8fa8-458ac1183001).html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Ewart, Marie-Ann. "Analysis of transcriptional regulatory elements of the human CD23 gene." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343975.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Daniels, Brodie Belinda. "Molecular and cellular analysis of the interaction between soluble CD23 and CD11/CD18 integrins." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1217.

Full text

Abstract:

The low affinity IgE receptor, CD23, is expressed by a wide variety of cells and cleaved from its original 45 kDa size to several smaller soluble CD23 proteins. Soluble CD23 function depends on the form of the protein and its interaction with various ligands. CD23 is believed to play an important role in regulating allergic responses and in inflammation, amongst others. β2 integrins are important in a variety of cell-adhesion reactions during immune-inflammatory mechanisms and the binding of their natural ligands generates outside-in cellular signalling, leading to cell activation. Although th

APA, Harvard, Vancouver, ISO, and other styles

17

Pereira, Melanie Claire. "The molecular analysis of the interation surface between sCD23 and the B2-integrins, CD11b & CD11c." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1014734.

Full text

Abstract:

Both CD23 and the β2 integrins (also known as CD11/CD18) have very important immunological functions, especially during the allergic response where the binding of CD23 to β2 integrins contributes to various types of signalling in monocytes which can result in drastic sensitivities experienced by some allergic individuals. CD23, also known as the low affinity receptor for immunoglobulin E or (FcεRII), is a type II transmembrane glycoprotein which is synthesized by haematopoietic cells and has biological activity in both membrane-bound and freely soluble forms. It acts via a number of receptors,

APA, Harvard, Vancouver, ISO, and other styles

18

Caven, Timothy Hays. "IGE PRODUCTION REGULATION VIA CD23 STALK ENGAGEMENT AND CELL CYCLE STIMULATION." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1643.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Potter, Sarah Jane. "Molecular analysis of human CD23 (Fc[epsilon]RII) protein isoform function." Thesis, University of Glasgow, 2001. http://theses.gla.ac.uk/2107/.

Full text

Abstract:

In the research described in this thesis, the trafficking of each CD23 isoform was studied in detail in both wild-type and mutant CD23 proteins, using an identical cell system and the same method of CD23 ligation for both isoforms. Confocal microscopic analysis demonstrated intracellular sorting differences to exist between the two isoforms, with CD23a utilising the endocytic pathway, and CD23b following both the endocytic and phagocytic pathways in a B-cell line. Site-directed mutagenesis was used to investigate a number of potentially key residues present in the unique N-terminal tail of eac

APA, Harvard, Vancouver, ISO, and other styles

20

Cooper, Ali. "The role of human CD23 in lgE homeostasis & allergic disease." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-human-cd23-in-lge-homeostasis--allergic-disease(9cf99ae7-3243-441e-b146-4a63c01127ec).html.

Full text

Abstract:

CD23, the low affinity receptor for IgE on B cells, exists in membrane and soluble forms. CD23 also binds CD21 with a distinct binding site to IgE. Soluble CD23 (sCD23) fragments are released from trimeric membrane CD23 (mCD23) by the endogenous metalloprotease, ADAM10. It has been suggested that trimeric sCD23 fragments can co-ligate membrane IgE (mIgE) and membrane CD21 (mCD21) on the surface of human B cells, in a similar way to C3d-antigen complexes and mIgM, to upregulate IgE synthesis and provoke allergic responses. To test this hypothesis, purified tonsil B cells were stimulated with IL

APA, Harvard, Vancouver, ISO, and other styles

21

Sprong, Kaitlin. "Analysis of the interaction between recombinant human Beta2 integrin I-domains and CD23." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1021078.

Full text

Abstract:

In order to further elucidate the interaction between CD23 and β2 integrins (CD11b/CD18) the following objectives were established: Expression and purification of CD11b I-domain as a GST-fusion protein using Escherichia coli; Cloning, synthesis and expression of CD18 I-Like domain.CD11b I-domain has previously been expressed as a GST-fusion protein (Daniels, 2010) and consequently led to comparable expression of CD18 I-like domain as a GST-fusion protein; Preparation of two site-directed mutants of CD18 I-Like domain in order to study the function of the serine residue involved in the S116P m

APA, Harvard, Vancouver, ISO, and other styles

22

Bertho, Jean-Marc. "Caracterisation des precurseurs lymphocytaires t humains : role du cd23 dans leur differenciation." Paris 6, 1991. http://www.theses.fr/1991PA066032.

Full text

Abstract:

La nature des precurseurs de la lignee lymphocytaire t humaine reste difficile a etablir. Nous avons pu isoler trois populations differentes de cellules pre-t, l'une d'origine medullaire, les deux autres d'origine thymique, sur la base de l'expression de l'antigene cd7, qui est l'un des marqueurs les plus precoces de la lignee lymphocytaire t. Ces cellules sont capables de se differencier in vitro pour donner des cellules t matures. L'etude de leurs caracteristiques phenotypiques et fonctionnelles a permis de proposer un schema des premieres etapes de la differenciation lymphocytaire t. La dif

APA, Harvard, Vancouver, ISO, and other styles

23

FOURCADE, CHRISTINE. "Expression et role du cd23 au niveau des stroma hematopoietiques chez l'homme." Paris 11, 1993. http://www.theses.fr/1993PA112209.

Full text

Abstract:

Sur la base de l'expression de l'antigene cd7 qui est l'un des marqueurs les plus precoces de la lignee lymphocytaire t, nous avons pu isoler des cellules cd7+ cd2. Ces cellules sont capables de se differencier in vitro en lymphocytes t matures en presence d'il1 et de cd23 et de proliferer en reponse a l'il3. La signification physiologique de ces donnees a ete confirmee par la mise en evidence de ces facteurs in vivo sur coupe de thymus au niveau des cellules epitheliales thymiques. Le cd23 est egalement exprime par les monocytes/macrophages du stroma medullaire ou il intervient dans l'autoren

APA, Harvard, Vancouver, ISO, and other styles

24

ROUSSELET, GERMAIN. "La proteine cd23 dans les carcinomes nasopharynges : etude biologique et approche clinique." Paris 6, 1992. http://www.theses.fr/1992PA066317.

Full text

Abstract:

Le carcinome indifferencie du nasopharynx constitue un probleme de sante publique, et un modele unique de cancerogenese multi-factorielle. Sa repartition geographique endemique suggere l'existence de facteurs environnementaux et/ou genetiques decisifs; le virus d'epstein-barr est toujours present dans les cellules tumorales et joue certainement un role dans la cancerogenese; les interactions entre les lymphocytes infiltrant la tumeur et les cellules malignes sont un element majeur de la biologie tumorale. La proteine cd23 ayant ete impliquee dans les processus d'immortalisation des lymphocytes

APA, Harvard, Vancouver, ISO, and other styles

25

Gu, Baijun. "TWO PATHWAYS OF SHEDDING OF L-SELECTIN AND CD23 FROM HUMAN B-LYMPHOCYTES." University of Sydney, 2000. http://hdl.handle.net/2123/821.

Full text

Abstract:

Lymphocytes from patients with B-chronic lymphocytic leukemia (B-CLL) express large numbers of P2X7 receptors for extracellular adenosine triphosphate (ATP). Activation of P2X7 receptors induces multiple downstream effects, of which the best documented is the opening of an ionic channel that is selective for divalent cations. Another effect of ATP is to induce the shedding of L-selectin (CD62L), a molecule which is involved in the adhesive interactions of lymphocytes on endothelial cells. High levels of soluble L-selectin and CD23 are found in the serum of patients with B-CLL, although the

APA, Harvard, Vancouver, ISO, and other styles

26

Wright, Tracey Jane. "Characterisation of CD23 cleavage by endogenous and exogenous proteases using neo-epitope antibodies." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29820.

Full text

Abstract:

CD23 is the low affinity IgE receptor. It is a type II integral transmembrane glycoprotein that can be shed from the cell surface forming soluble products of approximately 37, 33, 29, 25 and 16kDa. It appears that membrane and soluble CD23 have opposing regulatory functions and that inhibition of CD23 shedding may have potential to alleviate both allergic and inflammatory diseases. This has focused attention on the endogenous protease(s) responsible for CD23 shedding, leading to the demonstration that both the 37 and 33kDA sCD23 fragments are cleaved from the cell surface by a metalloprotease.

APA, Harvard, Vancouver, ISO, and other styles

27

Rückert, René. "Bakterielles Superantigen verstärkt die Atemwegsinflammation und bronchiale Atemwegsreagibilität in einem Mausmodell der allergischen Sensibilisierung." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14539.

Full text

Abstract:

Asthma Bronchiale (AB) ist eine chronisch- obstruktive, teilweise reversible Entzündung der Atemwege, deren klinisches Korellat die bronchiale Hyperreagibilität (BHR) ist. Es lassen sich aufgrund ethiologischer Faktoren extrinsiches und intrinsisches AB unterscheiden, wobei ersteres auf einer allergischen Sensibilisierung und letzteres auf irritativen oder infektbedingten entzündlichen Prozessen beruht. In der vorliegenden Arbeit wurde der Einfluß von bakteriellem Superantigen auf die Entzündungsreaktion und die bronchiale Hyperreagibilität untersucht. Stapylococcal enterotoxin B (SEB) wurde h

APA, Harvard, Vancouver, ISO, and other styles

28

Keith, Brooks. "IgE Enhances B Cell-Derived Exosomal Induced T Cell Proliferation." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2909.

Full text

Abstract:

For many years it has been known that the injection of antigen bound to an antibody leads to more than a 1000-fold increase in antigen specific antibody response. This observation holds true for IgE, which is dependent upon CD23 expression, as this enhancement is not present in mice deficient in CD23. It also has been shown that when mice are injected with IgE-antigen complexes also display an increase in antigen specific T cell proliferation. While there are published studies that demonstrate a role for B cell derived exosomes in the activation and proliferation of T cells, none have focuse

APA, Harvard, Vancouver, ISO, and other styles

29

BOURGET, ISABELLE. "Role de la molecule cd20 dans l'activation des lymphocytes b : regulation de l'expression du recepteur pour l'antigene et de la molecule cd23 (fc epsilon rii)." Nice, 1994. http://www.theses.fr/1994NICE4724.

Full text

Abstract:

La molecule cd20 est une phosphoproteine transmembranaire de 35/37 kda exprimee a la surface des cellules b depuis un stade precoce de leur maturation et jusqu'au stade plasmocyte. Nos resultats montrent que les anticorps diriges contre la molecule cd20 reduisent considerablement le niveau d'expression du recepteur pour l'antigene (migm) a la surface des cellules b. De plus, ils inhibent les effets inducteurs de l'interleukine-4 (il-4) sur l'expression de cette molecule. Dans ces conditions, on observe une diminution de la capacite des cellules b a etre activees par ce recepteur. Les anticorps

APA, Harvard, Vancouver, ISO, and other styles

30

Mathews, Joel. "ADAM10 exacerbation of allergic disease is potentially explained by its role in CD23 exosomal sorting." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2372.

Full text

Abstract:

CD23, the natural negative regulator of IgE, has been shown to be involved in asthma progression through its regulation of IgE. To investigate if its sheddase, ADAM10, is also involved in asthma progression, three mouse models were utilized; an IgE/mast cell dependent model, an IgE dependent, mast cell independent model and a mast cell and IgE independent model. Experimental asthma was then induced in mice which were selectively deficient for ADAM10 in B cells (ADAM10-/-) and compared to WT controls. The ADAM-/- mice had decreased signs of asthma, including eosinophilia, AHR and IgE synthes

APA, Harvard, Vancouver, ISO, and other styles

31

Santamaria, Kathleen. "Etude de l’hétérogénéité des centrocytes humains à travers l’expression du CD23 : différenciation en plasmablastes et expression d’une signature minimale transcriptionnelle au niveau cellule-unique comportant DEC2." Thesis, Rennes 1, 2020. http://www.theses.fr/2020REN1B038.

Full text

Abstract:

La différenciation terminale des lymphocytes B à travers le centre germinatif conduit à la production de cellules sécrétrices d’anticorps : les plasmocytes (PC) à longue durée de vie et de haute affinité pour l’antigène. Cette réaction implique la formation d’une microstructure anatomique qui comprend une zone sombre : lieu d’intenses proliférations des centroblastes et de maturation d’affinité de leur BCR, et une zone claire dans laquelle ont lieu les commutations de classes isotypiques du BCR et la sélection des centrocytes (CC). Ce processus est finement contrôlé par les lymphocytes T folli

APA, Harvard, Vancouver, ISO, and other styles

32

OUAAZ, FATEH. "Fonctions du cd23 soluble et membranaire dans la lignee myelomonocytaire. Etude des signaux intracellulaires." Paris 6, 1994. http://www.theses.fr/1994PA066419.

Full text

Abstract:

Le cd23 est le recepteur de basse affinite pour l'ige et possede sous sa forme soluble ou membranaire diverses activites biologiques. En synergie avec l'interleukine-1, le cd23 soluble est capable d'induire la differenciation in vitro des precurseurs lymphoides t et myeloides de la moelle osseuse humaine. Nous avons montre dans ce travail deux nouvelles activites cytokine du cd23 soluble: a) la regulation de la proliferation des precurseurs myeloides leucemiques et b) l'augmentation des reponses inflammatoires des monocytes humains. L'analyse des signaux intracellulaires et du recepteur du cd2

APA, Harvard, Vancouver, ISO, and other styles

33

Yoshikawa, Tsutomu. "Characterization of novel FcεRII/CD23 isoforms lacking the transmembrane segment in human cell lines". Kyoto University, 2002. http://hdl.handle.net/2433/149338.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Bund, Dagmar [Verfasser], and Michael [Akademischer Betreuer] Hallek. "hTERT, CD23 und CD229 als Tumorantigene bei der B-CLL / Dagmar Bund. Betreuer: Michael Hallek." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1024243443/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Housden, Jonathan E. M. "Lys 352 in human IgE is a major effector determinant residue in IgE-CD23 interaction." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443882.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Kao, Wen-Pin. "Protein engineering and characterization of a stable trimeric form of CD23 and a fluorescent IgE biosensor." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/protein-engineering-and-characterization-of-a-stable-trimeric-form-of-cd23-and-a-fluorescent-ige-biosensor(4b861bc3-fa5b-4590-9665-9507bcfcdbf5).html.

Full text

Abstract:

Immunoglobulin E (IgE) plays a critical role in allergic diseases such as asthma and atopic dermatitis. Cross-linking of IgE bound to its high affinity receptor, FceRI, by allergen on mast cells and basophils results in the release of inflammatory mediators and induces allergic reactions. IgE can also form a complex with its low affinity receptor, CD23, and CD21 on the B cell surface to regulate IgE synthesis. Hence, there are two possible strategies in the therapy of IgE-mediated disease: blocking IgE binding to FceRI and inhibiting IgE production. Crystal log raphic and FRET studies with a f

APA, Harvard, Vancouver, ISO, and other styles

37

Brignone, Chrystelle. "Régulation du clivage du récepteur de basse affinité pour les IgE (FceRII/CD23) : implication dans l'inflammation." Nice, 2001. http://www.theses.fr/2001NICE5667.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Siddorn, Philip David. "Efficient numerical modelling of wave-structure interaction." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:de36bd2f-cd23-4f11-b67f-9d8cd48ecd3c.

Full text

Abstract:

Offshore structures are required to survive in extreme wave environments. Historically, the design of these offshore structures and vessels has relied on wave-tank experiments and linear theory. Today, with advances in computing power, it is becoming feasible to supplement these methods of analysis with fully nonlinear numerical simulation. This thesis is concerned with the development of an efficient method to perform this numerical modelling, in the context of potential flow theory. The interaction of a steep ocean wave with a floating body involves a moving free surface and a wide range of

APA, Harvard, Vancouver, ISO, and other styles

39

Munoz, Olivier. "Régulation du clivage du récepteur de basse affinité pour les IgE (Fc[epsilon]RII/CD23 : importance de l'oligomérisation." Nice, 2000. http://www.theses.fr/2000NICE5417.

Full text

Abstract:

CD23 est le récepteur de basse affinité pour les IgE exprimé à la surface des cellules hématopoi͏̈étiques, dont les lymphocytes B ou les monocytes. La partie extracellulaire la plus distale de ce récepteur présente certaines homologies avec les lectines de type C, et contient les sites d'interaction pour différents ligands (IgE, CD21, CD11b /CD11c, CD47/VnR) qui rendent compte des propriétés biologiques de CD23. Le domaine lectine est connecté à la partie transmembranaire par une région en hélice α présentant un motif leucine-zipper, responsable de l'oligomérisation de la molécule. Cette régio

APA, Harvard, Vancouver, ISO, and other styles

40

Good, Samantha. "An investigation into the interaction of truncated recombinant IgE-Fc fragments with Fc&RI and CD23." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274954.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Becherel, Pierre-André. "Role du cd23 et de la no-synthetase dans l'activation des keratinocytes humains : implications en immunophysiopathologie et pharmacologie." Paris 6, 1999. http://www.theses.fr/1999PA066044.

Full text

Abstract:

Les keratinocytes epidermiques (ke) humains normaux sont exposes en permanence a des stimuli inflammatoires varies et a l'action de facteurs solubles secretes par les cellules du derme (lymphocytes, mastocytes, monocytes/macrophages, fibroblastes), notamment au cours des phenomenes allergiques et des processus infectieux ou anti-tumoraux. Apres stimulation prealable par de l'il-4, les keratinocytes apparaissent a ce jour comme les seules cellules non hematopoietiques a pouvoir exprimer le cd23 (recepteur de faible affinite pour les ige, fcrii) a leur surface. Ce cd23 est fonctionnel, puisque n

APA, Harvard, Vancouver, ISO, and other styles

42

Nazari, Naser. "An investigation into the interaction of truncated recombinant human CD23 fragments with IgE and their relevance in allergic disease." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425190.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Morel, Franck. "Etude de la sensibilité au CD23 soluble de lymphocites T et B humains dans certaines situations normales ou pathologiques." Poitiers, 1994. http://www.theses.fr/1994POIT2314.

Full text

Abstract:

La mise en evidence et l'etude par notre groupe d'un facteur de differenciation et d'activation lymphocytaire t (ptda) a revele ses analogies avec le scd23 de 25 kda. Le scd23 induit la differenciation des prothymocytes, de precurseurs cd34#+, de cellules b et augmente la synthese des ige. Nous avons demontre l'identite du scd23 et de la ptda, presente dans les surnageants de lymphocytes b normaux ou ebv-transformes. Le scd23 induit, en presence d'il1, une augmentation du taux de clonage des lymphocytes t cd4#+ stimules. Le scd23 ne modifie pas l'expression des antigenes cd2, 3, 4, 7, il2rs et

APA, Harvard, Vancouver, ISO, and other styles

44

Montagnac, Guillaume. "Etude du rôle du récepteur de faible affinité aux IgE, CD23, dans le transport transépithélial de complexes IgE/allergènes." Paris 5, 2005. http://www.theses.fr/2005PA05N11S.

Full text

Abstract:

Le récepteur de faible affinité aux IgE (CD) est impliqué dans le transport transépithélial de complexes IgE / allergène. Au niveau intestinal, ce transport est à l'origine du déclenchement allergique. Mon travail de thèse a visé à étudier le rôle du CD23 dans ce processus. Nous avons établi que les cellules épithéliales intestinales murines expriment la forme CD23b ainsi qu'une nouvelle forme épissée, bDELTA5, dont l'expression est induite par la sensibilisation in vivo. La régulation de l'internalisation du CD23 murin est complexe, faisant intervenir des domaines intra et extracellulaires. N

APA, Harvard, Vancouver, ISO, and other styles

45

Gibb, David. "ADAM10 is a critical regulator of B cell development, antibody production, and myeloid-derived suppressor cell expansion: Effects of B cell-specific ADAM10 deletion and overexpression in vivo." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2269.

Full text

Abstract:

Proteolytic processing of transmembrane receptors and ligands can have dramatic effects on cell signaling and subsequent cellular responses. Previous studies demonstrated that a disintegrin and metalloproteinase 10 (ADAM10) may cleave numerous B cell-expressed receptors, including the low affinity IgE receptor (CD23). However, lethality of ADAM10-deficient embryos has limited examination of these cleavage events in lymphocytes. To investigate their role in B cell development and function, we generated B cell-specific ADAM10 knockout mice. Intriguingly, deletion prevented development of the ent

APA, Harvard, Vancouver, ISO, and other styles

46

Rambert, Jérôme. "Recherche de nouvelles approches thérapeutiques anti-inflammatoires : inhibition des fonctions macrophagiques." Bordeaux 2, 2003. http://www.theses.fr/2003BOR21084.

Full text

Abstract:

Les macrpophages occupent un rôle central dans les réactions inflammatooires. Une des voies d'activation des macophages passe par la glycoprotéine de surface CD23. Le CD23 est un récepteur exprimé par de nombreuses cellules hématopoietiques et épithéliales. Quand il interagit avec ses ligands, le CD23 active les macrophages pour produire divers médiateurs dont les cytokines pro-inflammatoires et le monoxyde d'azote. Une augmentation du niveau de CD23 a été rapportée dans de nombreuses maladies inflammatoires dont la polyarthrite rhumatoide. Dans ce travail, nous avons tenté de bloquer la réact

APA, Harvard, Vancouver, ISO, and other styles

47

PAUL-EUGENE, DUGAS NATHALIE. "Regulation de l'expression et de la fonction du recepteur de basse affinite pour les ige (fcer2b/cd23) des monocytes/macrophages humains." Paris 7, 1993. http://www.theses.fr/1993PA077193.

Full text

Abstract:

Le recepteur de basse affinite pour les ige (cd23) est une molecule qui sous sa forme membranaire ou sous sa forme soluble est impliquee dans un grand nombre de pathologies parmi lesquelles on trouve l'allergie et les maladies parasitaires. L'etude des mecanismes regulant son expression et sa fonction permet d'evaluer son role fonctionnel dans ces pathologies et de definir, eventuellement de nouvelles approches therapeutiques. L'expression du cd23 a la surface des monocytes est induite par l'il-4. Cette expression est augmentee en presence d'agents regulant le metabolisme des nucleotides cycli

APA, Harvard, Vancouver, ISO, and other styles

48

Bader, Talisa [Verfasser], Manuel [Akademischer Betreuer] Weber, and Falk [Gutachter] Wehrhan. "Anzahl der Tumor und Lymphknoten infiltrierenden NK- Zellen (CD56, CD57) und dendritischen Zellen (CD21, CD23) bei kleinen, primären oralen Plattenepithelkarzinomen (OSCC) und deren Assoziation mit unterschiedlichen klinischen Verläufen / Talisa Bader ; Gutachter: Falk Wehrhan ; Betreuer: Manuel Weber." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/1241827265/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

DI, BERARDINO WILMA. "Implication du cytosquelette dans l'expression et le clivage du recepteur de basse affinite pour les ige (cd23) dans les lymphocytes b humains." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22008.

Full text

Abstract:

La molecule cd20, specifiquement exprimee a la surface des lymphocytes b, intervient dans l'activation et la differenciation de ces cellules. Nos resultats montrent que les anticorps monoclonaux diriges contre la proteine cd20 diminuent l'expression du recepteur de basse affinite pour les ige (cd23) induite par l'il-4 sur des lymphocytes b humains ainsi que son expression constitutive sur des cellules b transformees par le virus epstein-barr. Cet effet resulte d'une stimulation du clivage proteolytique extracellulaire de cd23. De plus, les anticorps diriges contre cd40, cmh classe i et ii prod

APA, Harvard, Vancouver, ISO, and other styles

50

ROTIROTI, MARIA CATERINA. "Characterization of Chimeric Antigen Receptors (CARs) as a potential tool for the treatment of Acute Myeloid Leukemia (AML)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241327.

Full text

Abstract:

La Leucemia Mieloide Acuta (LMA) è ancora associata ad alti tassi di ricaduta in seguito al trattamento con le terapie convenzionali che comprendono la chemioterapia e il trapianto di cellule staminali ematopoietiche. Da qui la necessità di identificare nuove strategie terapeutiche. L’immunoterapia con linfociti T ingegnerizzati per esprimere recettori chimerici artificiali (CARs) in grado di riconoscere specifici antigeni tumorali ha mostrato risultati sorprendenti in particolare nel contesto leucemie linfoblastiche di tipo B, suscitando un vivo interesse nell'estendere questo approccio anche

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!