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Journal articles on the topic 'CD23'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lones, Mark, and Ivan Kirov. "Cell Surface Targets for Monoclonal Antibody Therapy in Lymphoid Neoplasms of Children and Adolescents." Blood 104, no. 11 (2004): 4544. http://dx.doi.org/10.1182/blood.v104.11.4544.4544.

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Abstract Recently, monoclonal antibodies have become available for treatment of lymphoid neoplasms in adults, but have not been studied in children and adolescents. These monoclonal antibodies are directed against cell surface antigens CD20 (Rituximab, Ibritumomab-Tiuxetan, Tositumomab), CD22 (Epratuzumab), CD52 (CAMPATH-1H), HLA-DR Beta-chain (Hu1D10), CD23 (IDEC-152), and CD33 (Gemtuzumab Ozogamicin). The objective of this study is to identify cell surface targets eligible for monoclonal antibody therapy in lymphoid neoplasms of children and adolescents. This is a retrospective analysis of l

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2

Geisler, CH, JK Larsen, NE Hansen, et al. "Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia." Blood 78, no. 7 (1991): 1795–802. http://dx.doi.org/10.1182/blood.v78.7.1795.1795.

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Abstract Blood mononuclear cells from 540 newly diagnosed, unselected patients with B-cell chronic lymphocytic leukemia (CLL) were examined by immunofluorescence flow cytometry for a panel of surface membrane markers, including IgM and IgD, the monoclonal antibodies anti-CD3, -5, -20, -21, -22, -FMC7, and, for the final 125 patients, anti-CD23. There were 503 CD5+ and 37 CD5- cases. In the CD5+ cases, the cells typically expressed IgM, IgD, CD20, CD21, CD22, and CD23. In univariate analysis, age, clinical stage, IgM-fluorescence intensity, CD23, and FMC7 had significant prognostic importance,

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3

Geisler, CH, JK Larsen, NE Hansen, et al. "Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia." Blood 78, no. 7 (1991): 1795–802. http://dx.doi.org/10.1182/blood.v78.7.1795.bloodjournal7871795.

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Blood mononuclear cells from 540 newly diagnosed, unselected patients with B-cell chronic lymphocytic leukemia (CLL) were examined by immunofluorescence flow cytometry for a panel of surface membrane markers, including IgM and IgD, the monoclonal antibodies anti-CD3, -5, -20, -21, -22, -FMC7, and, for the final 125 patients, anti-CD23. There were 503 CD5+ and 37 CD5- cases. In the CD5+ cases, the cells typically expressed IgM, IgD, CD20, CD21, CD22, and CD23. In univariate analysis, age, clinical stage, IgM-fluorescence intensity, CD23, and FMC7 had significant prognostic importance, with high

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4

Escribano, Luis, Alberto Orfao, Jesús Villarrubia, et al. "Immunophenotypic Characterization of Human Bone Marrow Mast Cells. A Flow Cytometric Study of Normal and Pathological Bone Marrow Samples." Analytical Cellular Pathology 16, no. 3 (1998): 151–59. http://dx.doi.org/10.1155/1998/341340.

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The goal of the present paper was to define the immunophenotype of bone marrow mast cells (BMMC) from healthy controls and patients with hematologic malignancies (HM) based on the use of multiple stainings with monoclonal antibodies analyzed by flow cytometry. Our results show that BMMC from both groups of individuals display a similar but heterogenous immunophenotype. The overall numbers of BMMC are higher in the HM group of individuals (p= 0.08). Three patterns of antigen expression were detected: (1) markers constantly positive in all cases analyzed (CD9, CD29, CD33, CD43, CD44, CD49d, CD49

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5

Polishchuk, Alyona, Michael Zavelevich, and Daniil Gluzman. "VILLOUS LYMPHOCYTES IN BLOOD AND BONE MARROW IN SOME FORMS OF B-CELL LYMPHOID MALIGNANCIES." EUREKA: Life Sciences, no. 5 (September 30, 2020): 29–33. http://dx.doi.org/10.21303/2504-5695.2020.001429.

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The cytological and immunocytochemical features of the lymphocytes with villous morphology in peripheral blood and bone marrow in some B-lymphoproliferative disorders were studied. The diagnosis of hairy cell leukemia, a hairy cell leukemia variant, splenic marginal zone lymphoma and splenic diffuse red pulp small B-cell lymphoma was ascertained in accordance with the new revision of the WHO classification (2016). The neoplastic cells of hairy cell leukemia were determined by the presence of high tartrate resistant acid phosphatase (TRAP) activity. Cell surface expression of CD19, CD20 and CD2

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6

Galtseva, I. V., Yu A. Tsoy, A. E. Grachev, et al. "Multicolor flow cytometry in the diagnosis of Waldenstrom macroglobulinemia." Oncohematology 20, no. 1 (2025): 128–38. https://doi.org/10.17650/1818-8346-2025-20-1-128-138.

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Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma, the morphological substrates of which are b‑lymphocytes, proplasmocytes, and plasma cells. The world Health Organization recommends multicolor flow cytometry with analysis of markers such as IgM, Cd19, Cd20, Cd22, Cd25, Cd10, Cd23, Cd103, Cd138, for diagnosing this disease. Based on international and our own experience, we recommend that tumor b‑lymphocytes and plasma cells be analyzed separately for the diagnosis of waldenstrom macroglobulinemia, since the immunophenotypic profile of these populations differs. In diagnostics, this

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7

Alyona, Polishchuk, Zavelevich Michael, and Gluzman Daniil. "VILLOUS LYMPHOCYTES IN BLOOD AND BONE MARROW IN SOME FORMS OF B-CELL LYMPHOID MALIGNANCIES." EUREKA: Life Sciences, no. 5 (September 30, 2020): 29–33. https://doi.org/10.21303/2504-5695.2020.001429.

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The cytological and immunocytochemical features of the lymphocytes with villous morphology in peripheral blood and bone marrow in some B-lymphoproliferative disorders were studied. The diagnosis of hairy cell leukemia, a hairy cell leukemia variant, splenic marginal zone lymphoma and splenic diffuse red pulp small B-cell lymphoma was ascertained in accordance with the new revision of the WHO classification (2016). The neoplastic cells of hairy cell leukemia were determined by the presence of high tartrate resistant acid phosphatase (TRAP) activity. Cell surface expression of CD19, CD20 and CD2

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8

Paiva, Aldair Sousa, Alessandra Suelen Jardim Silva, Victor lima Soares, et al. "Importance of Flow Cytometry in the Differential Diagnosis of Hairy Cell Leukemia in the State of Rio Grande Do Norte, Brazil." Blood 136, Supplement 1 (2020): 14–15. http://dx.doi.org/10.1182/blood-2020-143225.

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Introduction:Hairy Cell Leukemia (HCL) is a B-cell non-Hodgkin's Lymphoma (B-NHL) representing about 2% of chronic leukemias, is manifested in adults with an average age of 55 years old or more and the ratio of male: female is 5:1, being more common among white people. It is characterized by the presence of neoplastic lymphocytes with cytoplasmic projections (villous cells), a characteristic commonly observed in other DLPCs such as variant HCL (HCL-v) and splenic villous cell lymphoma (SVCL), being the immunophenotyping by flow cytometry determinant in the differential diagnosis of these neopl

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9

Rousset, F., R. W. Malefijt, B. Slierendregt, et al. "Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-gamma." Journal of Immunology 140, no. 8 (1988): 2625–32. http://dx.doi.org/10.4049/jimmunol.140.8.2625.

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Abstract The effect of rIL-4 on the expression of low affinity receptor for the Fc part of IgE (Fc epsilon R2/CD23) and class II MHC antigens on Burkitt's lymphoma (BL) cell lines was investigated. Some of the BL lines contained low percentages of CD23 and HLA-DQ-positive cells, but virtually all cells expressed HLA-DR. IL-4 induced CD23 and class II MHC Ag expression on 7 of 9 BL. Optimal CD23 and class II MHC expression was observed after 48-72 h of incubation. Induction of CD23 and class II MHC Ag in the BL cell line BL2 by IL-4 was confirmed at the specific mRNA level. Significant activati

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10

Matutes, E., R. Morilla, K. Owusu-Ankomah, A. Houlihan, and D. Catovsky. "The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders." Blood 83, no. 6 (1994): 1558–62. http://dx.doi.org/10.1182/blood.v83.6.1558.1558.

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Abstract Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade disorder that regularly presents with peripheral blood involvement. We describe the immunophenotype of the circulating cells from 100 SLVL patients whose disease has been characterized on clinical, morphologic, and histologic grounds. Cells from all cases expressed B-cell antigens (CD19 and CD37) and/or HLA-Dr and showed light chain restriction (kappa/lambda: 1.5/1) with moderate to strong intensity of membrane Ig staining. Cells from most cases (> 80%) were CD24+, FMC7+, and expressed strongly membrane CD22. The monoc

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Matutes, E., R. Morilla, K. Owusu-Ankomah, A. Houlihan, and D. Catovsky. "The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders." Blood 83, no. 6 (1994): 1558–62. http://dx.doi.org/10.1182/blood.v83.6.1558.bloodjournal8361558.

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Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade disorder that regularly presents with peripheral blood involvement. We describe the immunophenotype of the circulating cells from 100 SLVL patients whose disease has been characterized on clinical, morphologic, and histologic grounds. Cells from all cases expressed B-cell antigens (CD19 and CD37) and/or HLA-Dr and showed light chain restriction (kappa/lambda: 1.5/1) with moderate to strong intensity of membrane Ig staining. Cells from most cases (> 80%) were CD24+, FMC7+, and expressed strongly membrane CD22. The monoclonal ant

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12

Rymkiewicz, Grzegorz, Renata Woroniecka, Katarzyna Blachnio, Barbara Pienkowska-Grela, and Jan Walewski. "Flow Cytometry and Fluorescence In Situ Hybridization Are Methods of Choice for Routine Diagnosis of Mantle Cell Lymphoma." Blood 106, no. 11 (2005): 4659. http://dx.doi.org/10.1182/blood.v106.11.4659.4659.

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Abstract Mantle cell lymphoma (MCL) is a distinct clinicopathologic entity, characterized by expansion of lymphocytes with co-expression of CD5 and CD20 and frequent t(11;14) translocation. MCL and its morphological variants are frequently confused with other lymphoma subtypes. The aim of this study was to analyze a contribution of histopathology (HP), immunohistochemistry (IHC), flow cytometry (FCM) and cytogenetic analysis with fluorescence in situ hybridization (FISH) to ultimate diagnosis of MCL. We identified 66 pts diagnosed with MCL either by use of HP/IHC or/and FCM. Initial diagnosis

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13

Gupta, Gaurav K., Xiaoping Sun, Constance M. Yuan, Maryalice Stetler-Stevenson, Robert J. Kreitman, and Irina Maric. "Usefulness of Dual Immunohistochemistry Staining in Detection of Hairy Cell Leukemia in Bone Marrow." American Journal of Clinical Pathology 153, no. 3 (2019): 322–27. http://dx.doi.org/10.1093/ajcp/aqz171.

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Abstract Objectives We evaluated efficacy of two dual immunohistochemistry (IHC) staining assays in assessing hairy cell leukemia (HCL) involvement in core biopsies and compared the results with concurrently collected flow cytometric data. Methods Overall, 148 patients with HCL (123 male, 25 female; mean age: 59.8 years; range: 25-81 years) had multiparameter flow cytometry performed using CD19, CD20, CD22, CD11c, CD25, CD103, CD123, surface light chains, CD5, and CD23. In parallel, bone marrow IHC was done using PAX5/CD103 and PAX5/tartrate-resistant alkaline phosphatase (TRAP) dual IHC stain

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14

Aubry, J. P., S. Pochon, J. F. Gauchat, et al. "CD23 interacts with a new functional extracytoplasmic domain involving N-linked oligosaccharides on CD21." Journal of Immunology 152, no. 12 (1994): 5806–13. http://dx.doi.org/10.4049/jimmunol.152.12.5806.

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Abstract Human CD21 has been described as a receptor for the C3d,g and iC3b proteins of complement, for the Epstein-Barr virus, and also for IFN-alpha. We reported recently that CD23, a low affinity receptor for IgE (Fc epsilon R2), is a new functional ligand for CD21. To determine the site of interaction of CD23 on CD21, we analyzed the ability of purified recombinant CD23 incorporated into fluorescent liposomes to bind CD21 mutants bearing various deletions of extracytoplasmic short consensus repeats (SCRs). We found that the site of interaction of CD23 on CD21 is on SCRs 5 to 8, with contri

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15

Frank, Robin R., Sucheta Jagan, Laura A. Paganessi, et al. "CD20, CD22, CD23, but Not CD37 Expression on CD19+ B-Cells Is Altered by Exogenous Factors in a Sub-Population of Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia (CLL/SLL) Patients,." Blood 118, no. 21 (2011): 3685. http://dx.doi.org/10.1182/blood.v118.21.3685.3685.

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Abstract Abstract 3685 Introduction: Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia (CLL/SLL) is a lymphoproliferative disorder that is characterized by the slow accumulation of malignant B cells. Patients follow heterogeneous clinical courses. The effectiveness of Rituximab, an anti-CD20 monoclonal antibody (mAb), is limited because target B cells from CLL patients express low levels of CD20. We previously reported that human serum suppresses CD20 expression ex vivo. Therefore, understanding mechanisms of low expression of CD20 as well as other target surface receptors would benefit

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16

Newman, RA, B. Peterson, FR Davey, et al. "Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study." Blood 82, no. 4 (1993): 1239–46. http://dx.doi.org/10.1182/blood.v82.4.1239.1239.

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Abstract The markers, CD11b, CD11c, CD14, CD21, CD23, CD25, CD38, and FMC7 were correlated with morphologic and other laboratory and clinical characteristics of 127 patients with untreated CD5+ chronic lymphocytic leukemia (CLL). Only CD38 and CD21 were significantly associated with atypical CLL morphology. The integrin associated markers CD11b and CD11c were associated with lower leukocyte count (white blood cell count [WBC]) and lower Rai stage. By contrast, the activation antigen CD23 was associated with a higher WBC, higher Rai stage, younger age group, and the presence of lymphadenopathy.

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17

Newman, RA, B. Peterson, FR Davey, et al. "Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study." Blood 82, no. 4 (1993): 1239–46. http://dx.doi.org/10.1182/blood.v82.4.1239.bloodjournal8241239.

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The markers, CD11b, CD11c, CD14, CD21, CD23, CD25, CD38, and FMC7 were correlated with morphologic and other laboratory and clinical characteristics of 127 patients with untreated CD5+ chronic lymphocytic leukemia (CLL). Only CD38 and CD21 were significantly associated with atypical CLL morphology. The integrin associated markers CD11b and CD11c were associated with lower leukocyte count (white blood cell count [WBC]) and lower Rai stage. By contrast, the activation antigen CD23 was associated with a higher WBC, higher Rai stage, younger age group, and the presence of lymphadenopathy. Therefor

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18

Osikov, M. V., E. A. Korobkin, A. A. Fedosov, and G. P. Dimov. "Relationship of the phenotype of peripheral blood lymphocytes and signs of osteopenia in patients with chronic lymphocytic leukemia." Russian Journal of Immunology 27, no. 2 (2024): 375–82. http://dx.doi.org/10.46235/1028-7221-16583-rot.

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Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries, characterized by the development of a number of complications, including osteoporosis, which is a prerequisite for studying its predictors. The purpose of the work is to investigate the relationship between immunophenotyping indicators of blood lymphocytes and osteodensitometry indicators in CLL. The study was conducted on 48 male patients with CLL aged 50-70 years with an average disease duration of 12 months and 14 apparently healthy men of the corresponding age (group 1). In the blood, CD5+, CD

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Wagner, Ulf G., Paul J. Kurtin, Andrea Wahner, et al. "The Role of CD8+ CD40L+ T Cells in the Formation of Germinal Centers in Rheumatoid Synovitis." Journal of Immunology 161, no. 11 (1998): 6390–97. http://dx.doi.org/10.4049/jimmunol.161.11.6390.

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Abstract In rheumatoid synovitis, lymphocytes can be arranged in follicular structures resembling secondary lymphoid follicles. To understand the organizing principles of this ectopic lymphoid tissue, the cellular components contributing to synovial follicles were examined. In 9 of 24 synovial tissue biopsies, lymphoid aggregates were found consisting of CD4+ T cells and CD20+ B cells. In four of the nine patients, the follicular centers were occupied by CD23+ CD21+ cellular networks representing follicular dendritic cells involved in germinal center reactions. In five patients, CD23+ cells we

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Chang, Heesoon, Yousang Gwack, Dior Kingston, et al. "Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA." Journal of Virology 79, no. 8 (2005): 4651–63. http://dx.doi.org/10.1128/jvi.79.8.4651-4663.2005.

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ABSTRACT Epstein-Barr virus (EBV) EBNA2 and Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) are recruited to their responsive elements through interaction with a Notch-mediated transcription factor, RBP-Jκ. In particular, RTA and EBNA2 interactions with RBP-Jκ are essential for the lytic replication of KSHV and expression of B-cell activation markers CD21 and CD23a, respectively. Here, we demonstrate that like EBV EBNA2, KSHV RTA strongly induces CD21 and CD23a expression through RBP-Jκ binding sites in the first intron of CD21 and in the CD23a core

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Debnath, Irina, Kirstin Roundy, Janis Weis, and John Weis. "Common Transcriptional Control Complexes of Murine CD21 and CD23 Suggests Stage Specific Repression (35.35)." Journal of Immunology 178, no. 1_Supplement (2007): S8. http://dx.doi.org/10.4049/jimmunol.178.supp.35.35.

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Abstract The expression of CD21 and CD23 is coincident in differentiating B cells during the T1 to T2 splenic transition stage. To define the factors regulating the expression of CD21 and CD23, we have used Chromatin Immunoprecipitation to map candidate transcription factors. Total naïve splenocytes showed constitutive binding of Oct1, NFATc3, YY1, NFkB-p52, PU.1, Pax5, E2A and RBP-Jk; to CD21 sequences (promoter and first intron) and NFkB-p52, Pax5, NFATc3, E2A and RBP-Jk to CD23 promoter sequences. Analysis of naïve T and B cell subsets showed constitutive binding of YY1, NFkB-p52, Pax5, O

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Srivastava, Bhaskar, William J. Quinn, Kristin Hazard, Jan Erikson, and David Allman. "Characterization of marginal zone B cell precursors." Journal of Experimental Medicine 202, no. 9 (2005): 1225–34. http://dx.doi.org/10.1084/jem.20051038.

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Selection of recently formed B cells into the follicular or marginal zone (MZ) compartments is proposed to occur by way of proliferative intermediates expressing high levels of CD21/35 and CD23. However, we show that CD21/35high CD23+ splenocytes are not enriched for proliferative cells, and do not contribute substantially to the generation of follicular B cells. Instead, ontogenic relationships, steady-state labeling kinetics, and adoptive transfer experiments suggest that CD21/35high CD23+ splenocytes serve primarily as precursors for MZ B cells, although their developmental potential seems

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23

Patuzzo, Giuseppe, Filippo Mazzi, Antonio Vella, et al. "Immunophenotypic Analysis of B Lymphocytes in Patients with Common Variable Immunodeficiency: Identification of CD23 as a Useful Marker in the Definition of the Disease." ISRN Immunology 2013 (April 4, 2013): 1–8. http://dx.doi.org/10.1155/2013/512527.

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Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by the failure of B lymphocytes differentiation leading to deficient immunoglobulins secretion. The identified genetic defects account only for a minority of cases. The importance of B cells immunophenotyping in the classification of CVID is known. This procedure can identify alterations on the cell surface molecules expression that could explain some immunological disorders characteristic of CVID. Moreover, some immunophenotypical aspects can correlate with clinical features of the disease. We used this proced

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White, Lindsey J., Bradford W. Ozanne, Pierre Graber, Jean-Pierre Aubry, Jean-Yves Bonnefoy, and William Cushley. "Inhibition of Apoptosis in a Human Pre-B–Cell Line by CD23 Is Mediated Via a Novel Receptor." Blood 90, no. 1 (1997): 234–43. http://dx.doi.org/10.1182/blood.v90.1.234.

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Abstract Human CD23 is a 45-kD type II membrane glycoprotein, which functions as a low-affinity receptor for IgE and as a ligand for the CD21 and CD11b/CD11c differentiation antigens. CD23 is released from the surface of cells as soluble fragments, and a 25-kD species of soluble CD23 (sCD23) appears to act as a multifunctional cytokine. In this report, sCD23 is shown to sustain the growth of low cell density cultures of a human pre-B–acute lymphocytic leukemia cell line, SMS-SB: no other cytokine tested was able to induce this effect. Flow cytometric analysis indicates that sCD23 acts to preve

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White, Lindsey J., Bradford W. Ozanne, Pierre Graber, Jean-Pierre Aubry, Jean-Yves Bonnefoy, and William Cushley. "Inhibition of Apoptosis in a Human Pre-B–Cell Line by CD23 Is Mediated Via a Novel Receptor." Blood 90, no. 1 (1997): 234–43. http://dx.doi.org/10.1182/blood.v90.1.234.234_234_243.

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Human CD23 is a 45-kD type II membrane glycoprotein, which functions as a low-affinity receptor for IgE and as a ligand for the CD21 and CD11b/CD11c differentiation antigens. CD23 is released from the surface of cells as soluble fragments, and a 25-kD species of soluble CD23 (sCD23) appears to act as a multifunctional cytokine. In this report, sCD23 is shown to sustain the growth of low cell density cultures of a human pre-B–acute lymphocytic leukemia cell line, SMS-SB: no other cytokine tested was able to induce this effect. Flow cytometric analysis indicates that sCD23 acts to prevent apopto

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D'Addona, Matteo, Luca Pezzullo, Valentina Giudice, et al. "CD38 Expression As an Additional Prognostic Marker in Mantle Cell Lymphoma." Blood 144, Supplement 1 (2024): 6250. https://doi.org/10.1182/blood-2024-198812.

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Mantle-cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by a t(11;14)(q13;q32) occurring in pre-B cells and determining uncontrolled cell proliferation. MCL cell immunophenotype is typically CD19+CD20+CD5+CD22+CD24+CD79a+CD43+FMC7+BCL2+CD10-CD11c-CD23-CD200-BCL6-CyclinD1+SOX11+; however, neoplastic clones could aberrantly express adhesion molecules that can augment tumor aggressiveness. In this study, we evaluated the prognostic impact in MCL of several surface markers currently used for immunophenotyping in other B-cell lymphomas. In this retrospective observational real-lif

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Weitzman, James, Monica Betancur, Laurent Boissel, Arthur P. Rabinowitz, and Hans Klingemann. "Variable Contribution of Different Monocloncal Antibodies to NK Cell-Mediated ADCC Against Primary CLL Cells." Blood 110, no. 11 (2007): 4715. http://dx.doi.org/10.1182/blood.v110.11.4715.4715.

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Abstract Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of the B-cell antigens CD19, 20 and 22, along with CD5 and CD23. These antigens make the malignant cells an ideal target for monoclonal antibody (mAb) therapy. Although the mechanism of action of mAbs is complex and not fully understood, one well-described action is antibody-dependent cellular cytotoxicity (ADCC). Binding of mAb to its target surface antigen initiates cytotoxicity through the interaction of the Fc portion of the mAb with the Fc receptor (FcR) on natural killer (NK) cells. This triggers release of pe

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Maitre, Elsa, Edouard Cornet, Véronique Salaün, et al. "Immunophenotypic Analysis of Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia-like (HCL-like) Disorders." Cancers 14, no. 4 (2022): 1050. http://dx.doi.org/10.3390/cancers14041050.

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Hairy cell leukemia (HCL) is characterized by abnormal villous lymphoid cells that express CD103, CD123, CD25 and CD11c. HCL-like disorders, including hairy cell leukemia variant (vHCL) and splenic diffuse red pulp lymphoma (SDRPL), have similar morphologic criteria and a distinct phenotypic and genetic profile. We investigated the immunophenotypic features of a large cohort of 82 patients: 68 classical HCL, 5 vHCL/SDRPL and 9 HCL-like NOS. The HCL immunophenotype was heterogeneous: positive CD5 expression in 7/68 (10%), CD10 in 12/68 (18%), CD38 in 24/67 (36%), CD23 in 22/68 (32%) and CD43 in

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Kuvshinov, Aleksei, Sergei Voloshin, Irina Martynkevich, et al. "Phenotypic Characteristics of Tumor Cells in Patients with Chronic Lymphocytic Leukemia into Different Prognostic Groups." Blood 126, no. 23 (2015): 5276. http://dx.doi.org/10.1182/blood.v126.23.5276.5276.

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Abstract Background. The presence or absence of certain cluster of differentiation on the tumor cells of chronic lymphocytic leukemia may affect the course of the disease. Influence of genetic abnormalities on the prognosis of the disease was also proved. Aim. To determine the relationship of the phenotype of tumor cells with genetic prognostic groups of patients with chronic lymphocytic leukemia (CLL). Methods. Thirty-five adult pts (median age 61 year, range 44 - 82; male 24, female 11) with diagnosed CLL were included in the study. The CLL was diagnosed according to the standard basic exami

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Yap, Hooi-Yeen, Thin-Sam Siow, Sook-Khuan Chow, and Sin-Yeang Teow. "Epstein-Barr Virus- (EBV-) Immortalized Lymphoblastoid Cell Lines (LCLs) Express High Level of CD23 but Low CD27 to Support Their Growth." Advances in Virology 2019 (March 28, 2019): 1–9. http://dx.doi.org/10.1155/2019/6464521.

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Epstein-Barr virus (EBV) is one of the common human herpesvirus types in the world. EBV is known to infect more than 95% of adults in the world. The virus mainly infects B lymphocytes and could immortalize and transform the cells into EBV-bearing lymphoblastoid cell lines (LCLs). Limited studies have been focused on characterizing the surface marker expression of the immortalized LCLs. This study demonstrates the generation of 15 LCLs from sixteen rheumatoid arthritis (RA) patients and a healthy volunteer using B95-8 marmoset-derived EBV. The success rate of LCL generation was 88.23%. All CD19

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Hibbert, Richard G., Peter Teriete, Gabrielle J. Grundy, et al. "The structure of human CD23 and its interactions with IgE and CD21." Journal of Experimental Medicine 202, no. 6 (2005): 751–60. http://dx.doi.org/10.1084/jem.20050811.

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The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcεRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response. We have determined the three-dimensional structure of the C-type lectin domain of CD23 in solution by nuclear magnetic resonance spectroscopy. An analysis of concentration-dependent chemical shift perturbations have allowed us to identify the residues engaged in self-association to the trimeric state, whereas ligand-induced changes have defined the binding sites for IgE and CD21. The r

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Dorion, R. Patrick, and John H. Shaw. "Intracytoplasmic Filamentous Inclusions in the Peripheral Blood of a Patient With Chronic Lymphocytic Leukemia." Archives of Pathology & Laboratory Medicine 127, no. 5 (2003): 618–20. http://dx.doi.org/10.5858/2003-127-0618-ifiitp.

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Abstract Intracellular inclusions in lymphoproliferative disorders are not common. Multiple different types of inclusions have been reported in chronic lymphocytic leukemia (CLL), including vacuoles, crystals, and pseudocrystals. Most of the reported cases were seen in the bone marrow lymphocytes, and the majority of these on electron microscopy. We report a case of long-standing CLL with no therapy that had filamentous cytoplasmic inclusions in the peripheral blood that were readily seen by light microscopy. Electron microscopy demonstrated dilated cisternae of the rough endoplasmic reticulum

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Otsuka, Masaki, Yoshihiro Yakushijin, Makoto Hamada, Takaaki Hato, Masaki Yasukawa, and Sigeru Fujita. "The Expression of the CD21 Antigen in Non-Hodgkin’s Lymphoma Is Involved in LFA-1 Expression and Tumor Survival." Blood 104, no. 11 (2004): 2285. http://dx.doi.org/10.1182/blood.v104.11.2285.2285.

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Abstract CD21/complement receptor type 2 is a membrane protein expressed on B lymphocytes, follicular dendritic cells, early thymocytes, and a subset of mature T lymphocytes. This major B cell antigen appears later than CD19 and CD20 in cell differentiation and is lost from the cell surface during the early stages of B cell activation. CD21 is characterized not only as a complement ligand but also as an adhesion molecule of the cell surface that is dependent on CD23 expression, suggesting that it may be involved in lymphocyte trafficking and several immune responses. Recently two groups have r

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Giordano Attianese, Greta Maria Paola, Virna Marin, Valentina Hoyos, et al. "In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor." Blood 117, no. 18 (2011): 4736–45. http://dx.doi.org/10.1182/blood-2010-10-311845.

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Abstract Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature CD19+CD5+CD20dim B lymphocytes that typically express the B-cell activation marker CD23. In the present study, we cloned and expressed in T lymphocytes a novel chimeric antigen receptor (CAR) targeting the CD23 antigen (CD23.CAR). CD23.CAR+ T cells showed specific cytotoxic activity against CD23+ tumor cell lines (average lysis 42%) and primary CD23+ CLL cells (average lysis 58%). This effect was obtained without significant toxicity against normal B lymphocytes, in contrast to CARs targeting CD19 or CD20

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Lee, Hye Won, Hyunwoo Lee, Chanho Park, et al. "Pattern of Tumor-Infiltrating Lymphocytes in Mixed Epithelial and Stromal Tumor of the Kidney: A Review of Five Cases." Cells 10, no. 4 (2021): 917. http://dx.doi.org/10.3390/cells10040917.

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Mixed epithelial and stromal tumor of the kidney (MESTK), a benign rare tumor with malignant transformation potential, is thought to be derived from fetal or immature cells originating from the mesonephric and Müllerian ducts. However, due to its rarity, little is known about the anti-tumor immune responses in MESTK. Herein, we present five cases of MESTK and evaluate the population of tumor-infiltrating lymphocytes (TILs) using a freshly obtained MESTK sample. Microscopically, TILs were scattered or clustered in large aggregates in the stroma in all five cases; furthermore, three cases exhibi

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Palathingal Bava, E., W. liu, Y. Shen, et al. "Composite Lymphoma Comprising of BCL2 Rearrangement Negative, CD23 Positive Follicle Center Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Case Report." American Journal of Clinical Pathology 162, Supplement_1 (2024): S75—S76. http://dx.doi.org/10.1093/ajcp/aqae129.167.

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Abstract Introduction/Objective BCL2 rearrangement negative, CD23-positive follicle center cell lymphoma (BCL2 neg CD23 pos FCL) is a rare, recently described provisional entity in International Consensus Classification (2022). It has a predominantly diffuse growth pattern and often involves inguinal region. The molecular profile includes a high frequency of STAT6 and CREBBP co-mutation as well as 1q gain and a recurrent 1p36 loss/TNFRS14 abnormalities. We describe a composite tumor comprising of a rare entity BCL2 neg CD23 pos FCL and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (C

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Blanco, Gonzalo, Xiao J. Yan, Anita Kar Yun Ng, et al. "Normal B Cells in MBL Are Biased Toward Antigen-Experienced B Cells, with Increased Percentages of DN1 Cells in IGHV-Mutated MBL and ABC/DN2 Cells in IGHV-Unmutated MBL Suggesting Distinct Follicular/Extrafollicular Maturation Pathways." Blood 144, Supplement 1 (2024): 1851. https://doi.org/10.1182/blood-2024-211202.

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Background. People with the pre-leukemic condition MBL suffer from immune deficiency, a major cause of death in CLL. This immune deficiency affects both the B and T cell lineages, and the causative mechanism(s) are not well defined. We previously determined that the CD5- normal B cell (NBC) compartment of people with MBL exhibits distinct transcriptomes compared to healthy donors. Moreover, NBC from MBL patients of distinct IGHV mutation status differ. Hypothesis. The variations in NBC transcriptomes stem from differences in the distribution of NBC subsets, and these cell subsets differ accord

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Onguru, Daniel, YanMei Liang, Jennifer Elliot, Pauline Mwinzi, and Lisa Ganley-Leal. "CD23b Isoform Expression in Human Schistosomiasis Identifies a Novel Subset of Activated B Cells." Infection and Immunity 79, no. 9 (2011): 3770–77. http://dx.doi.org/10.1128/iai.05094-11.

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ABSTRACTResistance to schistosomiasis is associated with increased levels of serum parasite-specific IgE. IgE exerts its functions through its cellular receptors, FcεRI and FcεRII/CD23; however, its functional significance in humans requires further characterization. We previously reported that increased levels of CD23+B cells correlate with resistance to schistosomiasis in hyperexposed populations and sought to define their potential function and relationship with IgE. We found that CD23+B cells are a heterogeneous cell population with functional and phenotypic differences. Circulating CD23+B

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Semanaj, Valentina, Arbi Pecani, Teuta Dedej, et al. "The Diagnostic Value of Flow Cytometry Imunophenotyping in an Albanian Patient Population with a Preliminary Clinical Diagnosis of Chronic Lymphocytic Leukemia." Open Access Macedonian Journal of Medical Sciences 2, no. 1 (2014): 51–55. http://dx.doi.org/10.3889/oamjms.2014.009.

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Objective: Based on the flow cytometry multiparametric immunophenotyping methodology we studied some useful cell marker criteria needed for the practical differentiation of the chronic lymphocytic leukemia from other chronic limphoproliferative diseases with a leukemic component.Materials and Methods: The applied methodology is a four color flow cytometry multiparametric immunophenotyping technique using EDTA blood samples taken from 84 consecutive patients diagnosed with CLL through a preliminary clinical and white blood cell examination. The following fluorescent stained monoclonal antibodie

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Gu, B., L. J. Bendall, and J. S. Wiley. "Adenosine Triphosphate–Induced Shedding of CD23 and L-Selectin (CD62L) From Lymphocytes Is Mediated by the Same Receptor but Different Metalloproteases." Blood 92, no. 3 (1998): 946–51. http://dx.doi.org/10.1182/blood.v92.3.946.

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Abstract CD23 is a transmembrane protein expressed on the surface of B-lymphocytes that binds IgE, CD21, CD11b, and CD11c. High concentrations of soluble CD23 and L-selectin are found in the serum of patients with B-chronic lymphocytic leukemia (B-CLL). Because extracellular adenosine triphosphate (ATP) causes shedding of L-selectin via activation of P2Z/P2X7 receptors expressed on B-CLL lymphocytes, we studied the effect of ATP on shedding of CD23. ATP-induced shedding of CD23 at an initial rate of 12% of that for L-selectin, whereas the EC50 for ATP was identical (35 μmol/L) for shedding of

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Gu, B., L. J. Bendall, and J. S. Wiley. "Adenosine Triphosphate–Induced Shedding of CD23 and L-Selectin (CD62L) From Lymphocytes Is Mediated by the Same Receptor but Different Metalloproteases." Blood 92, no. 3 (1998): 946–51. http://dx.doi.org/10.1182/blood.v92.3.946.415a24_946_951.

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CD23 is a transmembrane protein expressed on the surface of B-lymphocytes that binds IgE, CD21, CD11b, and CD11c. High concentrations of soluble CD23 and L-selectin are found in the serum of patients with B-chronic lymphocytic leukemia (B-CLL). Because extracellular adenosine triphosphate (ATP) causes shedding of L-selectin via activation of P2Z/P2X7 receptors expressed on B-CLL lymphocytes, we studied the effect of ATP on shedding of CD23. ATP-induced shedding of CD23 at an initial rate of 12% of that for L-selectin, whereas the EC50 for ATP was identical (35 μmol/L) for shedding of both mole

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Dragovic-Ivancevic, Tijana, Nada Kraguljac-Kurtovic, Vesna Knezevic, et al. "The role of immunophenotyping in differential diagnosis of chronic lymphocytic leukemia." Srpski arhiv za celokupno lekarstvo 142, no. 3-4 (2014): 197–203. http://dx.doi.org/10.2298/sarh1404197d.

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Introduction. Accurate diagnosis of chronic lymphocytic leukemia (CLL) acquires immunophenotyping by flow cytometry in order to facilitate differential diagnosis between CLL and other mature B-cell neoplasms (MBCN). Objective. The aim of this study was to define immunological profile of CLL cells. Methods. Immunophenotyping by flow cytometry was performed on peripheral blood specimens at diagnosis in the group of 211 patients with de novo MBCN. Results. Absolute count of B-cells was significantly increased in all MBCN patients comparing to healthy control group (p<0.05). B-cell monoclonalit

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Guo, Jinzhou, Gao Si, and Fuchun Si. "Association of immune cells and the risk of esophageal cancer: A Mendelian randomization study in a East Asian population." Medicine 103, no. 18 (2024): e38064. http://dx.doi.org/10.1097/md.0000000000038064.

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Immunotherapy has been used in esophageal cancer (EC), but the causal relationship between EC and immune cells is not clear. Although the cellular phenotype has been reported as a biomarker for immunotherapy, the biomarker studies for immunotherapy in EC still face great challenges. Comprehensive 2-sample Mendelian randomization (MR) analysis was performed to determine the causal association between immune cell signatures and EC in this study. Based on publicly available genetic data, we explored causal associations between 731 immune cell signatures and EC risk. EC had no statistically signif

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Attianese, Greta Maria Paola Giordano, Valentina Hoyos, Virna Marin, et al. "A New Chimeric Antigen Receptor (CAR) Targeting the CD23 Antigen Expressed by Chronic Lymphocytic Leukemia (B-CLL) Cells." Blood 116, no. 21 (2010): 2446. http://dx.doi.org/10.1182/blood.v116.21.2446.2446.

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Abstract Abstract 2446 B-Chronic lymphocytic leukemia (B-CLL) is characterized by a progressive accumulation of B-lymphocytes expressing CD19, CD20dim and aberrantly expressing the CD5 T-cell marker. Moreover, they over-express the B-cell activation marker CD23. Chimeric Antigen Receptors (CAR) are engineered molecules able to redirect T-cell killing/effector activity towards a selected target in a non MHC-restricted manner. First trials targeting B-CLL were based on both monoclonal antibodies and anti-CD19/anti-CD20.CAR-transduced T cells. However, this approach causes the elimination of norm

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Jung, Georges, Sylvie Thiebault, Jean-Claude Eisenmann, et al. "Quantitative Phenotyping and Discriminant Analysis Improve Scoring Classification in Late B-Lymphoproliferative Disorders." Blood 106, no. 11 (2005): 1463. http://dx.doi.org/10.1182/blood.v106.11.1463.1463.

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Abstract Multivariate analysis classification of chronic lymphocytic leukemia (CLL) and lymphoma (non-CLL) disorders is investigated in 299 patients by an extended panel of surface markers, and compared with Matutes classical scoring proposal. Diagnosis was based on clinical features, cell morphology, node or bone marrow histology, and immunological scoring system. Results are obtained on directly labeled tumoral cells by flow cytometry gating. Patients included 154 CLL, 2 Richter transformation, and 143 lymphoma (26 follicular, 49 lymphocytic, 18 other low-grade, 7 Waldenström macroglobuline

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Huang, N., MM Kawano, MS Mahmoud, et al. "Expression of CD21 antigen on myeloma cells and its involvement in their adhesion to bone marrow stromal cells." Blood 85, no. 12 (1995): 3704–12. http://dx.doi.org/10.1182/blood.v85.12.3704.bloodjournal85123704.

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The mature myeloma cells express very late antigen 5 (VLA-5) and MPC-1 antigens on their surface and adhere to bone marrow (BM) stromal cells more tightly than the VLA-5-MPC-1-immature myeloma cells in vitro. The VLA-5 and MPC-1 antigens possibly function as two of the molecules responsible for interaction of mature myeloma cells with BM stromal cells. However, the immature myeloma cells do interact with BM stromal cells, and it is unclear which adhesion molecules mediate their interaction. In this study, we found that both immature and mature myeloma cells expressed CD21, an adhesion molecule

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Pollan, Sara G., Arezoo Hanifi, James Hargrove, et al. "Abstract 627: Custom Vectra® Polaris™ fluorescent multiplex IHC panel identifies mature tertiary lymphoid structures in colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): 627. http://dx.doi.org/10.1158/1538-7445.am2022-627.

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Abstract Introduction: Tertiary lymphoid structures (TLS) are promising prognostic indicators of positive outcomes for patients with solid tumors including colorectal cancer (CRC) [1]. Large-scale retrospective analysis shows patients with mature TLS in particular respond to PD-1/PD-L1 antibody treatment with improved objective response, progression-free and overall survival [2]. Since not all patients respond to PD-1/PD-L1 antibody treatment, identifying patients with mature TLS is clinically relevant as it enables selection of patients likely to respond to immune checkpoint blockade. Mature

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Zhang, John, David Chin, Adam Anthony, et al. "CD5 and CD23 Positive Mantle Cell Lymphoma Detected by Flow Cytometry and Confirmed by FISH Study t(11;14)." Blood 104, no. 11 (2004): 4814. http://dx.doi.org/10.1182/blood.v104.11.4814.4814.

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Abstract The differential diagnoses of CD5 positive B-cell lymphoproliferative disorders mainly include chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma. Occasionally large cell and marginal zone lymphomas may also be CD5 positive. An accurate diagnosis effects patient management. The classical immunophenotype for chronic lymphocytic leukemia/small lymphocytic lymphoma is CD19/CD5/CD23 positive FMC-7 negative cells with dim CD20 and dim light chain expressions, while mantle cell lymphoma is CD19/CD5/FMC-7 positive with bright CD20 and bright light chai

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Bonnefoy, Jean-Yves, Jean-François Gauchat, Paul Life, Pierre Graber, Jean-Pierre Aubry, and Sybille Lecoanet-Henchoz. "Regulation of IgE Synthesis by CD23/CD21 Interaction." International Archives of Allergy and Immunology 107, no. 1-3 (1995): 40–42. http://dx.doi.org/10.1159/000236924.

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Chan, Marcia, Nicole Gigliotti, and Lanny Rosenwasser. "Asthma: A missense SNP in the FCER2 (CD23) gene favors increased IgE production by human B cells (57.2)." Journal of Immunology 188, no. 1_Supplement (2012): 57.2. http://dx.doi.org/10.4049/jimmunol.188.supp.57.2.

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Abstract Asthma now is the most common chronic condition in children. Many asthmatics are unresponsive to therapy and genetic predisposition likely contributes. Pharmacogenetic studies have highlighted novel sequence variants in several genes. One such gene is fcϵr2, encoding the low affinity IgE receptor CD23 (FcϵRII). CD23 is expressed on several cell types and has several roles in IgE-mediated immunity, including antigen focusing and presentation to TH2 cells; mediating production of pro-inflammatory cytokines by monocytes; transporting IgE and allergen-IgE complexes through gastrointestina

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