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Relevant bibliographies by topics / CD27-ligand

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Academic literature on the topic 'CD27-ligand'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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Journal articles on the topic "CD27-ligand"

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Gravestein, L. A., W. van Ewijk, F. Ossendorp, and J. Borst. "CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development." Journal of Experimental Medicine 184, no. 2 (1996): 675–85. http://dx.doi.org/10.1084/jem.184.2.675.

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CD27 is a lymphocyte-specific member of the TNF receptor family and has a TNF-related transmembrane ligand, CD70. The CD27/CD70 receptor-ligand pair cooperates with the TCR in the regulation of the peripheral T cell response. The study presented here reveals that CD27 may play a similar role in thymic pre-T cell development. We have previously cloned the cDNA encoding murine CD27, prepared specific mAbs and observed that murine CD27 is expressed on virtually all thymocytes, with the exception of a subpopulation of CD4-8- precursor T cells. It is shown here that induction of murine CD27 express

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2

Hintzen, Rogier Q., Susanne M. A. Lens, Gerrit Koopman, Steven T. Pals, Hergen Spits, and René A. W. van Lier. "CD70 represents the human ligand for CD27." International Immunology 6, no. 3 (1994): 477–80. http://dx.doi.org/10.1093/intimm/6.3.477.

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3

Ranheim, EA, MJ Cantwell, and TJ Kipps. "Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells." Blood 85, no. 12 (1995): 3556–65. http://dx.doi.org/10.1182/blood.v85.12.3556.bloodjournal85123556.

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Crosslinking the CD27 antigen on T cells provides a costimulatory signal that, in concert with T-cell receptor crosslinking, can induce T-cell proliferation and cellular immune activation. We find that chronic lymphocytic leukemia (CLL) B cells from most patients coexpress both membrane-bound and soluble CD27, along with its newly identified ligand, CD70. The expression of soluble CD27 may preclude leukemic B cells from stimulating T cells via CD70, thereby potentially impairing their ability to function as effective antigen-presenting cells. We find that leukemic B-cell expression of soluble

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4

Teplyakov, Alexey, Galina Obmolova, Thomas J. Malia, and Gary L. Gilliland. "Crystal structure of CD27 in complex with a neutralizing noncompeting antibody." Acta Crystallographica Section F Structural Biology Communications 73, no. 5 (2017): 294–99. http://dx.doi.org/10.1107/s2053230x17005957.

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CD27 is a T-cell and B-cell co-stimulatory glycoprotein of the tumor necrosis factor (TNF) receptor superfamily that is dependent on the availability of the TNF-like ligand CD70. Therapeutic approaches to treating autoimmune diseases and cancers with antagonistic and agonistic anti-CD27 monoclonal antibodies (mAbs), respectively, have recently been developed. Mouse anti-human CD27 mAb 2177 shows potency in neutralizing CD70-induced signaling; however, it does not block the binding of soluble CD70. To provide insight into the mechanism of action of the mAb, the crystal structure of the CD27 ext

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5

Agematsu, Kazunaga, Haruo Nagumo, Yumiko Oguchi, et al. "Generation of Plasma Cells From Peripheral Blood Memory B Cells: Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction." Blood 91, no. 1 (1998): 173–80. http://dx.doi.org/10.1182/blood.v91.1.173.

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Abstract B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control the entry into the pathway to plasma cells have been unclear. Triggering via CD27 by CD27 ligand (CD70) on purified peripheral blood B cells yielded an increase in the number of plasma cells in the presence of interleukin-10 (IL-10). Differentiation into plasma cells by a combination of IL-10 and CD70 transfectants occurred in CD27+ B cells but not in CD27− B cells. Moreover, addition of IL-2 to the IL-10 and CD70-transfect activation system greatly induced di

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Agematsu, Kazunaga, Haruo Nagumo, Yumiko Oguchi, et al. "Generation of Plasma Cells From Peripheral Blood Memory B Cells: Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction." Blood 91, no. 1 (1998): 173–80. http://dx.doi.org/10.1182/blood.v91.1.173.173_173_180.

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B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control the entry into the pathway to plasma cells have been unclear. Triggering via CD27 by CD27 ligand (CD70) on purified peripheral blood B cells yielded an increase in the number of plasma cells in the presence of interleukin-10 (IL-10). Differentiation into plasma cells by a combination of IL-10 and CD70 transfectants occurred in CD27+ B cells but not in CD27− B cells. Moreover, addition of IL-2 to the IL-10 and CD70-transfect activation system greatly induced differentia

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7

Ochsenbein, Adrian F., Stanley R. Riddell, Michele Brown, et al. "CD27 Expression Promotes Long-Term Survival of Functional Effector–Memory CD8+Cytotoxic T Lymphocytes in HIV-infected Patients." Journal of Experimental Medicine 200, no. 11 (2004): 1407–17. http://dx.doi.org/10.1084/jem.20040717.

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Human immunodeficiency virus (HIV)-specific CD8+ T cells persist in high frequencies in HIV-infected patients despite impaired CD4+ T helper response to the virus, but, unlike other differentiated effector cytotoxic T lymphocytes, most continue to express the tumor necrosis factor receptor family member CD27. Because the ligand for CD27 (CD70) is also overexpressed in HIV-infected hosts, we examined the nature of expression and potential functional consequences of CD27 expression on HIV-specific CD8+ T cells. Analysis of CD27+ and CD27− T cells derived from the same HIV-specific clone revealed

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8

Tai, Yu-Tzu, Xian-Feng Li, Rory Coffey, et al. "CD27-Mediated Apoptosis Is Dependent on Siva-Induced Caspase Activation in Human Multiple Myeloma." Blood 106, no. 11 (2005): 3398. http://dx.doi.org/10.1182/blood.v106.11.3398.3398.

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Abstract CD27, a member of tumor necrosis factor receptor superfamily that lacks a death domain in its cytoplasmic region, and its interaction with its ligand, CD70, is crucial for differentiation into plasma cells. In malignant B cells, aberrant expression and reverse signaling of CD70 might contribute to disease progression. Recent studies showed that CD27 is heterogeneously expressed on multiple myeloma (MM) plasma cells and the expression is reduced with the progression of MM. However, a possible role for the loss of CD27-CD70 interaction in myelomagenesis was never defined. In this study,

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Deng, Yun, Bithi Chatterjee, Kyra Zens, et al. "CD27 is required for protective lytic EBV antigen–specific CD8+ T-cell expansion." Blood 137, no. 23 (2021): 3225–36. http://dx.doi.org/10.1182/blood.2020009482.

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Abstract Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8

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Riether, Carsten, Christian M. Schürch, Elias D. Bührer, et al. "CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia." Journal of Experimental Medicine 214, no. 2 (2016): 359–80. http://dx.doi.org/10.1084/jem.20152008.

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Aberrant proliferation, symmetric self-renewal, increased survival, and defective differentiation of malignant blasts are key oncogenic drivers in acute myeloid leukemia (AML). Stem cell gene signatures predict poor prognosis in AML patients; however, with few exceptions, these deregulated molecular pathways cannot be targeted therapeutically. In this study, we demonstrate that the TNF superfamily ligand–receptor pair CD70/CD27 is expressed on AML blasts and AML stem/progenitor cells. CD70/CD27 signaling in AML cells activates stem cell gene expression programs, including the Wnt pathway, and

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Dissertations / Theses on the topic "CD27-ligand"

1

Tesselaar, Nanda Antoinette. "CD27/CD70 interactions in effector and memory cell formation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/84656.

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Conference papers on the topic "CD27-ligand"

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Sefrin, Julian P., David M. Richards, Katharina Billian-Frey, et al. "Abstract 4845: HERA-CD27L, a true CD27 agonist, is a hexavalent CD27 ligand that enhances T cell activation and induces potent anti-tumor immunity." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4845.

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Sefrin, Julian P., David M. Richards, Katharina Billian-Frey, et al. "Abstract 4845: HERA-CD27L, a true CD27 agonist, is a hexavalent CD27 ligand that enhances T cell activation and induces potent anti-tumor immunity." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4845.

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