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Journal articles on the topic 'CD271 Marker'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Peng, Qiuyue, Martyna Duda, Guoqiang Ren, et al. "Multiplex Analysis of Adipose-Derived Stem Cell (ASC) Immunophenotype Adaption to In Vitro Expansion." Cells 10, no. 2 (2021): 218. http://dx.doi.org/10.3390/cells10020218.

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In order to enhance the therapeutic potential, it is important that sufficient knowledge regarding the dynamic changes of adipose-derived stem cell (ASC) immunophenotypical and biological properties during in vitro growth is available. Consequently, we embarked on a study to follow the evolution of highly defined cell subsets from three unrelated donors in the course of eight passages on tissue culture polystyrene. The co-expression patterns were defined by panels encompassing seven and five cell surface markers, including CD34, CD146, CD166, CD200, CD248, CD271, and CD274 and CD29, CD31, CD36

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2

Liang, L., Ludivine Coudière Morrison, Nazanin Tatari, et al. "15 CD271/p75NTR is a novel diagnostic marker, prognostic indicator and therapeutic target for SHH medulloblastoma." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, S3 (2018): S12—S13. http://dx.doi.org/10.1017/cjn.2018.294.

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The extensive heterogeneity both between and within the medulloblastoma (MB) subgroups underscores a critical need for variant-specific biomarkers and therapeutic strategies. We previously identified a role for the CD271/p75 neurotrophin receptor (p75NTR) in regulating stem/progenitor cells in the SHH MB subgroup. Here, we demonstrate the utility of CD271 as a novel diagnostic and prognostic marker for SHH MB using immunohistochemical analysis as well as transcriptome data across 763 primary tumors. Characterization of CD271+ and CD271- cells by RNA sequencing revealed that these two subpopula

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3

Tormin, Ariane, Jan Claas Brune, Stuart Walsh, Johan Richter, Xiaolong Fan, and Stefan Scheding. "Human Primary Mensenchymal Stromal Progenitor Cells Are Highly Enriched in Both, the CD271+/CD146+ and CD271+/CD146− Bone Marrow Population with the Latter Acquiring CD146 Expression upon Culture in-Vitro." Blood 112, no. 11 (2008): 2422. http://dx.doi.org/10.1182/blood.v112.11.2422.2422.

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Abstract Culture-derived mesenchymal stromal cells (MSC), which are attractive candidates for clinical cell therapy approaches, arise from primary MSC progenitor/stem cells in the bone marrow. Recently, several groups have reported markers (CD271, CD146, GD2, SSEA4, etc.) that allowed for an enrichment of CFU-F, i.e. primary MSC progenitors. However, the exact phenotype of the bona fide mesenchymal stem/progenitor cells has not yet not been sufficiently defined. We therefore aimed to investigate primary MSC in bone marrow subpopulations defined by the expression of CD271 and CD146, as both mar

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Peng, Qiuyue, Guoqiang Ren, Zongzhe Xuan, et al. "Distinct Dominant Lineage from In Vitro Expanded Adipose-Derived Stem Cells (ASCs) Exhibits Enhanced Wound Healing Properties." Cells 11, no. 7 (2022): 1236. http://dx.doi.org/10.3390/cells11071236.

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It has been suggested that immunophenotypically defined lineages within the in vitro expanded adipose-derived stem cell (ASC) may play a beneficial role from the perspective of a personalized intervention. Therefore, to better understand the implications of different surface marker profiles for the functionality, we set out to examine the evolution of ASC-variants based on the co-expression of five bright or eight dim epitopes. At passages P1, P4, and P8, the co-localization of five bright markers (CD73, CD90, CD105, CD166, and CD201), or eight dim markers (CD34, CD36, CD200, CD248, CD271, CD2

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Tormin, Ariane, Ou Li, Stuart Walsh, Mats Ehinger, Jan Claas Brune, and Stefan Scheding. "CD146 Expression in Primary Bone Marrow MSC Progenitor/Stem Cells Is Dependent On Their In Vivo Location." Blood 114, no. 22 (2009): 251. http://dx.doi.org/10.1182/blood.v114.22.251.251.

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Abstract Abstract 251 Primary MSC progenitor/stem cells (MSC-PC/SC) represent only a minute fraction of the bone marrow cells and they give rise to the well-known mesenchymal stromal cells (MSC) in culture. In vivo, MSC-PC/SC are probable constituents of the hematopoietic stem cell niche, thus playing an important role in supporting, maintaining and controlling hematopoiesis. Enrichment of primary MSC progenitors, i.e. CFU-F, has been recently reported based on expression of surface markers such as CD271, CD146, GD2, SSEA4, etc. Based on the expression of CD271 and CD146 on primary MSC (Quiric

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6

Elkashty, Osama A., Ghada Abu Elghanam, Xinyun Su, Younan Liu, Peter J. Chauvin, and Simon D. Tran. "Cancer stem cells enrichment with surface markers CD271 and CD44 in human head and neck squamous cell carcinomas." Carcinogenesis 41, no. 4 (2019): 458–66. http://dx.doi.org/10.1093/carcin/bgz182.

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Abstract Head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate of 50%. One potential reason for treatment failure is the presence of cancer stem cells (CSCs). Several cell markers, particularly CD44, have been used to isolate CSCs. However, isolating a pure population of CSC in HNSCC still remains a challenging task. Recent findings show that normal oral stem cells were isolated using CD271 as a marker. Thus, we investigated the combined use of CD271 and CD44 to isolate an enriched subpopulation of CSCs, followed by their characterization in vitro, in vivo, and in patie

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7

Bellagamba, Bruno Corrêa, Patrícia Bencke Grudzinski, Pedro Bins Ely, Paulo de Jesus Hartmann Nader, Nance Beyer Nardi, and Lindolfo da Silva Meirelles. "Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids." Stem Cells International 2018 (July 31, 2018): 1–14. http://dx.doi.org/10.1155/2018/7357213.

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Cultured mesenchymal stromal cells (MSCs) are cells that can be used for tissue engineering or cell therapies owing to their multipotency and ability to secrete immunomodulatory and trophic molecules. Several studies suggest that MSCs can become pericytes when cocultured with endothelial cells (ECs) but failed to use pericyte markers not already expressed by MSCs. We hypothesized ECs could instruct MSCs to express the molecules CD271 or CD34, which are expressed by pericytes in situ but not by MSCs. CD271 is a marker of especial interest because it is associated with multipotency, a characteri

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8

Han, Bo La, Lan Zhou, Qiunong Guan, Gerald da Roza, Hao Wang, and Caigan Du. "In VitroExpansion and Characterization of Mesenchymal Stromal Cells from Peritoneal Dialysis Effluent in a Human Protein Medium." Stem Cells International 2018 (October 3, 2018): 1–10. http://dx.doi.org/10.1155/2018/5868745.

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The therapeutic potential of mesenchymal stromal cells (MSCs) from various tissue origins have extensively been explored in both experimental and clinical studies, and peritoneal dialysis effluent-derived MSC (pMSC) may be an easily obtainable MSC source for clinical applications. In this study, we expanded and characterized the pMSCs after expansion in a human protein culture medium. The pMSCs were expanded in plastic dishes with the human protein medium. MSC marker expression was examined by flow cytometry. Spherical formation was tested by hanging drop method, and osteogenic, adipogenic, an

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9

Jiang, Ying, Jennifer Powers, George F. Muschler, and Jaroslaw P. Maciejewski. "Expression of CD271 in Normal and Malignant Hematopoietic Progenitor and Stem Cells." Blood 108, no. 11 (2006): 4271. http://dx.doi.org/10.1182/blood.v108.11.4271.4271.

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Abstract The relationship between mesenchymal (MSC) and hematopoietic stem cells (HSC) involves close interaction in the marrow microenvironment. They also may share certain phenotypic features and even possibly a multipotent common precursor. CD271 (also known as LNGFR, p75NTR) has been reported to be a suitable marker of resting primitive MSCs. CD271 and its ligands, neurotrophins (NTs, e.g. nerve growth factor) also play important roles in hematopoiesis, such as enhancement of colony formation by human bone marrow progenitor cells. Dysregulated expression or mutations of NT receptors were a

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10

Cheli, Yann, Vanessa F. Bonnazi, Arnaud Jacquel, et al. "CD271 is an imperfect marker for melanoma initiating cells." Oncotarget 5, no. 14 (2014): 5272–83. http://dx.doi.org/10.18632/oncotarget.1967.

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11

Malenke, Elke, Christiane Dorn, Stefan Wirths, Martin Rudolf Mueller, Lothar Kanz, and Hans-Georg Kopp. "Expression of neurotrophins and their receptors in adult sarcomas." Journal of Clinical Oncology 31, no. 15_suppl (2013): 10562. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10562.

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10562 Background: Neurotrophins (NT) influence proliferation, survival, death, and differentiation by binding Tropomyosin-related kinase (Trk) receptors and p75NTR(CD271). While the three Trk-receptors TrkA, TrkB, and TrkC display specific binding to their ligands, i.e. TrkA to NGF (nerve growth factor), TrkB to BDNF (brain-derived neurotrophic factor), NT4/5 (neurotrophin 4/5) and TrkC to NT3 (neurotrophin 3), CD271 shows low affinity to all neurotrophins. Notably, CD271 has been suggested as marker for the prospective isolation of bone marrow mesenchymal stromal cells (MSC), and rhabdomyosar

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12

Lieser, Elizabeth Ann Teresa, Alexey A. Leontovich, Shernan G. Holtan, Wendy Kay Nevala, and Svetomir Markovic. "Exhibition of a stem-cell like phenotype with the expression of CD271 in drug-resistant melanoma cells." Journal of Clinical Oncology 30, no. 15_suppl (2012): 8599. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.8599.

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8599 Background: Chemotherapy resistance is a common, difficult problem for melanoma patients needing long term care and those suffering from recurrence. Neural growth factor receptor (NGFR), also known as CD271, is commonly expressed on mesenchymal stem cells and is important for development, survival and differentiation of cells. This has previously shown to be expressed on melanoma stem cells. We hypothesized that treatment with carboplatin enriches the population of tumor cells for cancer stem cells (CSC) as a mechanism of chemotherapy resistance. Methods: Core tumor samples from 118 patie

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13

Buhring, Hans-Jorg, Venkata L. Battula, Sabrina Treml, Lothar Kanz, and Wichard Vogel. "Novel Markers for the Isolation of Primary Bone Marrow Derived MSC with Multi-Lineage Differentiation Capacity." Blood 108, no. 11 (2006): 2573. http://dx.doi.org/10.1182/blood.v108.11.2573.2573.

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Abstract We have previously described a novel culture protocol to grow MSC from bone marrow (BM) and non-amniotic placenta (PL) with an immature phenotype and multi-lineage differentiation capacity (1). Using the low affinity nerve growth factor receptor (CD271) (2) as a key marker for isolation of MSC derived from femur shaft bone marrow cells (BM-MSC) of patients undergoing a total hip replacement, we could identify two CD271+ distinct populations: CD271dull and CD271bright cells. Two-color flow cytometer analysis revealed that only the CD271bright population coexpressed the mesenchymal mark

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14

Beretti, Francesca, Martina Gatti, Manuela Zavatti, Sara Bassoli, Giovanni Pellacani, and Tullia Maraldi. "Reactive Oxygen Species Regulation of Chemoresistance and Metastatic Capacity of Melanoma: Role of the Cancer Stem Cell Marker CD271." Biomedicines 11, no. 4 (2023): 1229. http://dx.doi.org/10.3390/biomedicines11041229.

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BRAF mutations are present in 30–50% of cases of cutaneous melanoma, and treatment with selective BRAF and MEK inhibitors has been introduced. However, the development of resistance to these drugs often occurs. Chemo-resistant melanoma cells show increased expression of CD271, a stem cell marker that features increased migration. Concordantly, resistance to the selective inhibitor of oncogenic BRAFV600E/K, vemurafenib, is mediated by the increased expression of CD271. It has recently been shown that the BRAF pathway leads to an overexpression of the NADPH oxidase Nox4, which produces reactive

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15

Ferreira-Facio, Cristiane de Sá, Vitor Botafogo, Patrícia Mello Ferrão, et al. "Flow Cytometry Immunophenotyping for Diagnostic Orientation and Classification of Pediatric Cancer Based on the EuroFlow Solid Tumor Orientation Tube (STOT)." Cancers 13, no. 19 (2021): 4945. http://dx.doi.org/10.3390/cancers13194945.

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Early diagnosis of pediatric cancer is key for adequate patient management and improved outcome. Although multiparameter flow cytometry (MFC) has proven of great utility in the diagnosis and classification of hematologic malignancies, its application to non-hematopoietic pediatric tumors remains limited. Here we designed and prospectively validated a new single eight-color antibody combination—solid tumor orientation tube, STOT—for diagnostic screening of pediatric cancer by MFC. A total of 476 samples (139 tumor mass, 138 bone marrow, 86 lymph node, 58 peripheral blood, and 55 other body flui

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16

Alvarez, Ruth, Hye-Lim Lee, Christine Hong, and Cun-Yu Wang. "Single CD271 marker isolates mesenchymal stem cells from human dental pulp." International Journal of Oral Science 7, no. 4 (2015): 205–12. http://dx.doi.org/10.1038/ijos.2015.29.

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17

Shen, Yupeng, Chenzhi Xu, Xin Liu, et al. "CD271 Serves as a Marker for Tumor-Initiating Cells in Laryngocarcinoma." Discovery Medicine 37, no. 194 (2025): 542. https://doi.org/10.24976/discov.med.202537194.46.

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18

Maijenburg, Marijke, Marion Kleijer, Erik Mul, Floris van Alphen, Ellen van der Schoot, and Carlijn Voermans. "Primary Bone Marrow-Derived MSC Subsets with Distinct Wnt Expression Profiles Are Dynamically Distributed During Human Life." Blood 116, no. 21 (2010): 2590. http://dx.doi.org/10.1182/blood.v116.21.2590.2590.

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Abstract Abstract 2590 Mesenchymal stromal cells (MSC) in bone marrow (BM) consist of a heterogeneous population of cells. MSC orchestrate the BM microenvironment, and therefore have a pivotal role in hematopoietic support. Since MSC produce a large quantity and variety of Wnt proteins, it is likely that Wnts are involved in their hematopoietic support function Recent studies show enrichment for BM-derived MSC by sorting for CD271+ or CD146+ cells. However, it is unclear whether these markers are co-expressed with classical markers MSC markers CD73, CD105 and CD90. In addition mainly adult sam

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19

Hejbøl, Eva K., Mohammad A. Hajjaj, Ole Nielsen, and Henrik D. Schrøder. "Marker Expression of Interstitial Cells in Human Skeletal Muscle: An Immunohistochemical Study." Journal of Histochemistry & Cytochemistry 67, no. 11 (2019): 825–44. http://dx.doi.org/10.1369/0022155419871033.

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There is a growing recognition that myogenic stem cells are influenced by their microenvironment during regeneration. Several interstitial cell types have been described as supportive for myoblasts. In this role, both the pericyte as a possible progenitor for mesenchymal stem cells, and interstitial cells in the endomysium have been discussed. We have applied immunohistochemistry on normal and pathological human skeletal muscle using markers for pericytes, or progenitor cells and found a cell type co-expressing CD10, CD34, CD271, and platelet-derived growth factor receptor α omnipresent in the

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20

Al Bahrawy, Mohamed. "Comparison of the Migration Potential through Microperforated Membranes of CD146+ GMSC Population versus Heterogeneous GMSC Population." Stem Cells International 2021 (March 11, 2021): 1–14. http://dx.doi.org/10.1155/2021/5583421.

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Background. Guided tissue regeneration (GTR) is a powerful modality for periodontal regeneration, but it blocks the periosteum and gingival stem cells (GMSCs), from supporting periodontal wound by the nutrients, growth factors, and regenerative cells. The microperforated membrane considered a rewarding solution for this major drawback; GMSCs can migrate through a GTR microperforated membrane toward a chemoattractant, with the blocking of other unfavorable epithelial cells and fibroblasts. In the absence of a sole marker for MSC, a homogeneous population of GMSC is difficult to isolate; using C

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Peng, Qiuyue, Hiva Alipour, Simone Porsborg, Trine Fink, and Vladimir Zachar. "Evolution of ASC Immunophenotypical Subsets During Expansion In Vitro." International Journal of Molecular Sciences 21, no. 4 (2020): 1408. http://dx.doi.org/10.3390/ijms21041408.

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Adipose-derived stromal/stem cells (ASCs) are currently being considered for clinical use for a number of indications. In order to develop standardized clinical protocols, it is paramount to have a full characterization of the stem cell preparations. The surface marker expression of ASCs has previously been characterized in multiple studies. However, most of these studies have provided a cross-sectional description of ASCs in either earlier or later passages. In this study, we evaluate the dynamic changes of 15 different surface molecules during culture. Using multichromatic flow cytometry, AS

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Álvarez-Viejo, María. "CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture." World Journal of Stem Cells 7, no. 2 (2015): 470. http://dx.doi.org/10.4252/wjsc.v7.i2.470.

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23

Lichtenegger, Felix S., Isabell Kondla, Michael Krempasky, et al. "Coinhibitory Expression Profiling of AML Blasts Identifies HVEM as Prognostic Marker in AML." Blood 122, no. 21 (2013): 1359. http://dx.doi.org/10.1182/blood.v122.21.1359.1359.

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Abstract Acute myeloid leukemia (AML) is a highly heterogeneous disease. Numerous cytogenetic and molecular markers distinguish different biological and prognostic groups. Immunological effects play an important role for the treatment of AML, especially for the eradication of minimal residual disease, as proven by the success of allogeneic stem cell transplantation and some autologous immunotherapeutic strategies. However, various immunosuppressive factors dampen these potential effects. For several malignancies, the relevance of coinhibitory receptor ligand interactions that influence the int

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Liang, Lisa, Ludivine Morrison, Nazanin Tatari, et al. "PDTM-05. CD271 (p75NTR) AS A NOVEL DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR SHH MEDULLOBLASTOMA." Neuro-Oncology 19, suppl_6 (2017): vi190. http://dx.doi.org/10.1093/neuonc/nox168.770.

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25

Liang, Lisa, Ludivine Coudiere-Morrision, Nazanin Tatari, et al. "PDTB-21. CD271 (p75NTR) AS A NOVEL DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR SHH MEDULLOBLASTOMA." Neuro-Oncology 18, suppl_6 (2016): vi154. http://dx.doi.org/10.1093/neuonc/now212.640.

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26

Liang, Lisa, Ludivine Coudiere-Morrison, Nazanin Tatari, et al. "MEDU-12. CD271 (P75NTR) AS A NOVEL DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR SHH MEDULLOBLASTOMA." Neuro-Oncology 19, suppl_4 (2017): iv40. http://dx.doi.org/10.1093/neuonc/nox083.163.

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27

Watson, J. Tracy, Teresa Foo, Jin Wu, et al. "CD271 as a Marker for Mesenchymal Stem Cells in Bone Marrow versus Umbilical Cord Blood." Cells Tissues Organs 197, no. 6 (2013): 496–504. http://dx.doi.org/10.1159/000348794.

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28

LI, SULAN, DONGLI YUE, XINFENG CHEN, et al. "Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity." Oncology Reports 33, no. 1 (2014): 425–32. http://dx.doi.org/10.3892/or.2014.3569.

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29

Lichtenegger, Felix S., Michael Krempasky, Karsten Spiekermann, Jan Braess, Wolfgang Hiddemann, and Marion Subklewe. "Costimulatory Expression Profiling of AML Blasts Identifies Surface Markers with High Correlation to Isolated NPM1 Mutation." Blood 118, no. 21 (2011): 2511. http://dx.doi.org/10.1182/blood.v118.21.2511.2511.

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Abstract Abstract 2511 Acute myeloid leukemia (AML) is a heterogeneous disease. In recent years, numerous cytogenetic and molecular markers providing prognostic information have been established. The success of allogeneic stem cell transplantation and some autologous immunotherapeutic strategies has proven that immunological effects play an important role for treatment of AML, especially for the eradication of minimal residual disease. However, the effect is dampened by immunosuppressive factors provided by AML blasts. One of the possible immunomodulatory mechanisms is the expression pattern o

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Cugno, Chiara, Rita Calzone, Giusy Gentilcore, et al. "Towards a Standardization and Characterization of Clinical Grade Adipose-Derived Stromal Cells." Blood 134, Supplement_1 (2019): 5013. http://dx.doi.org/10.1182/blood-2019-130385.

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INTRODUCTION Mesenchymal Stromal Cells (MSCs) are multipotent cells with regenerative, anti-inflammatory, immunomodulatory and anti-tumorigenic properties, which are readily isolated from aspirates of adipose tissue (AT) due to their high availability. Compared with alternative sources, AT provides high cell yield. Despite the numerous clinical trials in autologous and allogeneic settings for various diseases worldwide, there are no US FDA-approved MSC-based products. Challenges for clinical translation of MSC-based therapies largely lie in the sourcing, production and basic characterization o

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Murillo-Sauca, Oihana, Man Ki Chung, June Ho Shin, et al. "CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma." Oncotarget 5, no. 16 (2014): 6854–66. http://dx.doi.org/10.18632/oncotarget.2269.

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32

Redmer, T., I. Walz, B. Klinger, et al. "The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells." Oncogenesis 6, no. 1 (2017): e291-e291. http://dx.doi.org/10.1038/oncsis.2016.88.

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van Strien, Miriam E., Jacqueline A. Sluijs, Brent A. Reynolds, Dennis A. Steindler, Eleonora Aronica, and Elly M. Hol. "Isolation of Neural Progenitor Cells From the Human Adult Subventricular Zone Based on Expression of the Cell Surface Marker CD271." STEM CELLS Translational Medicine 3, no. 4 (2014): 470–80. http://dx.doi.org/10.5966/sctm.2013-0038.

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Freund, Eric, Juliane Moritz, Matthias Stope, Christian Seebauer, Anke Schmidt, and Sander Bekeschus. "Plasma-Derived Reactive Species Shape a Differentiation Profile in Human Monocytes." Applied Sciences 9, no. 12 (2019): 2530. http://dx.doi.org/10.3390/app9122530.

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Background: Monocyte-derived macrophages are key regulators and producers of reactive oxygen and nitrogen species (ROS/RNS). Pre-clinical and clinical studies suggest that cold physical plasma may be beneficial in the treatment of inflammatory conditions via the release of ROS/RNS. However, it is unknown how plasma treatment affects monocytes and their differentiation profile. Methods: Naïve or phorbol-12-myristate-13-acetate (PMA)-pulsed THP-1 monocytes were exposed to cold physical plasma. The cells were analyzed regarding their metabolic activity as well as flow cytometry (analysis of viabi

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Jäger, Katharina, Lionel Larribère, Huizi Wu, Christel Weiss, Christoffer Gebhardt, and Jochen Utikal. "Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis." Cancers 11, no. 1 (2019): 76. http://dx.doi.org/10.3390/cancers11010076.

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Regulation of particular genes during the formation of neural crest (NC) cells is also described during progression of malignant melanoma. In this context, it is of paramount importance to develop neural crest models allowing the identification of candidate genes, which could be used as biomarkers for melanoma prognosis. Here, we used a human induced Pluripotent Stem Cells (iPSC)-based approach to present novel NC-associated genes, expression of which was upregulated in melanoma. A list of 8 candidate genes, based on highest upregulation, was tested for prognostic value in a tissue microarray

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Nakahara, S., S. Fukushima, J. Yamashita, et al. "479 Verification of the AT-rich interaction domain-containing protein 3B as a potent stem cell marker of melanoma comparing with CD271." Journal of Investigative Dermatology 136, no. 9 (2016): S242. http://dx.doi.org/10.1016/j.jid.2016.06.501.

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37

Ruoss, Severin, J. Todd Walker, Chanond A. Nasamran, et al. "Strategies to Identify Mesenchymal Stromal Cells in Minimally Manipulated Human Bone Marrow Aspirate Concentrate Lack Consensus." American Journal of Sports Medicine 49, no. 5 (2021): 1313–22. http://dx.doi.org/10.1177/0363546521993788.

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Background: There is a need to identify and quantify mesenchymal stromal cells (MSCs) in human bone marrow aspirate concentrate (BMAC) source tissues, but current methods to do so were established in cultured cell populations. Given that surface marker and gene expression change in cultured cells, it is doubtful that these strategies are valid to quantify MSCs in fresh BMAC. Purpose: To establish the presence, quantity, and heterogeneity of BMAC-derived MSCs in minimally manipulated BMAC using currently available strategies. Study Design: Descriptive laboratory study. Methods: Five published s

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Parfejevs, V., M. Gavare, L. Cappiello, M. Grube, R. Muceniece, and U. Riekstina. "Evaluation of Biochemical Changes in Skin-Derived Mesenchymal Stem Cells duringIn VitroNeurodifferentiation by FT-IR Analysis." Spectroscopy: An International Journal 27 (2012): 315–20. http://dx.doi.org/10.1155/2012/286542.

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Recently FT-IR analysis has been employed to study changes in molecular signatures during embryonic stem cell differentiation. We were interested to find out whether FT-IR spectroscopy could be applied to analyze changes in human skin mesenchymal stem cell (S-MSC) biochemical profile duringin vitroneurodifferentiation. S-MSCs were propagated in serum-free medium with EGF and FGF-2 during six weeks. Neural progenitor cell line ReNcell CX (Millipore) was used as a reference cell line. Samples were collected each week and analyzed for neural marker nestin, tubulinβIII, GFAP, and CD271 expression.

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Severe, Nicolas, Murat Karabacak, Ninib Baryawno, et al. "Distinct Stress Responses of Bone Marrow Stromal Cell Subgroups Defined by Unbiased Single-Cell Mass-Cytometry Analysis." Blood 128, no. 22 (2016): 430. http://dx.doi.org/10.1182/blood.v128.22.430.430.

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Abstract The bone marrow niche is a heterogeneous tissue comprised of multiple cell types that collectively regulate hematopoiesis. It is thought to be a critical stress sensor, integrating information at the level of the organism down to signals at the level of the single cell. In so doing, the niche orchestrates hematopoietic stem and progenitor cell (HSPC) responses to organismal stress. However, most studies of the niche have depended on genetic marker or deletion studies that inherently limit analysis to the selected indicator genes or cells. While this has greatly enhanced our understand

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Wemmert, Silke, Martina Pyrski, Lukas Pillong, et al. "Widespread Distribution of Luteinizing Hormone/Choriogonadotropin Receptor in Human Juvenile Angiofibroma: Implications for a Sex-Specific Nasal Tumor." Cells 13, no. 14 (2024): 1217. http://dx.doi.org/10.3390/cells13141217.

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Juvenile angiofibroma (JA) is a rare, sex-specific, and highly vascularized nasal tumor that almost exclusively affects male adolescents, but its etiology has been controversial. The G protein-coupled hormone receptor LHCGR [luteinizing hormone (LH)/choriogonadotropin (hCG) receptor] represents a promising new candidate for elucidating the underlying mechanisms of sex specificity, pubertal manifestation, and JA progression. We used highly sensitive RNAscope technology, together with immunohistochemistry, to investigate the cellular expression, localization, and distribution of LHCGR in tissue

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Krueger, Kimberly, Zsuzsanna Mayer, Miriam Gerckens, Stefan Boeck, Peter Luppa, and Stefan Holdenrieder. "High Quality Performance of Novel Immunoassays for the Sensitive Quantification of Soluble PD-1, PD-L1 and PD-L2 in Blood." Biomedicines 10, no. 10 (2022): 2405. http://dx.doi.org/10.3390/biomedicines10102405.

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Programmed death-1 receptor PD-1(CD279) and its corresponding ligands PD-L1(CD274, B7-H1) and PD-L2(CD273, B7-DC) play important roles in physiological immune tolerance and for immune escape in cancer disease. Hence, the establishment and analytical validation of a novel enzyme-linked immunosorbent assay (ELISA) to measure soluble PD-1, PD-L1 and PD-L2 in blood samples according to high quality standards is required. Antibody pairs were used to establish novel highly sensitive ELISAs for all three markers on an open electrochemiluminescence Quickplex platform. Analytical validation comprised i

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Tucci, Marco, Stella D’Oronzo, Francesco Mannavola, et al. "Dual-procedural separation of CTCs in cutaneous melanoma provides useful information for both molecular diagnosis and prognosis." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592090541. http://dx.doi.org/10.1177/1758835920905415.

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Background: Circulating tumor cells (CTCs) have recently emerged as a new dynamic soluble marker for several malignancies including cutaneous melanoma (CM) and are suitable for prognostic evaluations and treatment monitoring. However, to date many limitations still hamper the wide-scale application of CTCs in CM setting, including the lack of standardized methods as well as both low levels and heterogeneity of these cells. Methods: We developed a protocol for CTC detection in CM based on immune-magnetic sorting to deplete CD45-, CD31- or CD34-positive cells, followed by dielectrophoretic DEPAr

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Madelung, Ann Brinch, Michael Bzorek, Henrik Bondo, et al. "A Novel Immunohistochemical Sequential Multi-Labelling and Erasing Technique Enables Epitope Characterization of Bone Marrow Pericytes In Primary Myelofibrosis." Blood 116, no. 21 (2010): 4108. http://dx.doi.org/10.1182/blood.v116.21.4108.4108.

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Abstract Abstract 4108 Background: In Philadelphia-negative chronic myeloproliferative neoplasms (MPN) increased microvascular density, bizarre vessel architecture and increased number of pericytes are distinct histopathological features; apart from the characteristic proliferation of myeloid cell lines and the progressive accumulation of connective tissue in the bone marrow. Pericytes express several markers such as CD146, CD271, Smooth Muscle Actin (SMA), Desmin, Platelet-derived growth factor receptor beta and Neuron-glial 2. However, these markers are also expressed in other cell types of

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Li, Hongzhe, Roshanak Ghazanfari, Nicholas Ditzel, Moustapha Kassem та Stefan Scheding. "Candidate Human Primary Mesenchymal Stem/Progenitor Cells Are Highly Enriched in Linneg/CD45neg/CD271pos/PDGFRαneg Bone Marrow Cells". Blood 120, № 21 (2012): 3460. http://dx.doi.org/10.1182/blood.v120.21.3460.3460.

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Abstract Abstract 3460 Human bone marrow (BM) contains a rare population of non-hematopoietic mesenchymal stem cells (BM-MSC) which can differentiate toward skeletal lineages such as osteoblasts, adipocytes, chondrocytes and hematopoiesis-supporting stromal cells. In vivo, BM-MSC are essential constituents of the hematopoietic stem cell niche, thus playing an important role in supporting, maintaining and controlling hematopoiesis. We and others have previously shown that primary BM-MSC were exclusively found in the linneg/CD45neg/CD271pos cell fraction in human bone marrow, and we furthermore

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Ilkhanizadeh, Shirin, Aileen Gracias, Andreas K. O. Åslund, et al. "STEM-19. LIVE DETECTION OF NEURAL STEM AND GLIOBLASTOMA CELLS BY A LUMINESCENT CONJUGATED OLIGOTHIOPHENE DERIVATIVE." Neuro-Oncology 24, Supplement_7 (2022): vii35. http://dx.doi.org/10.1093/neuonc/noac209.136.

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Abstract Glioblastoma (GBM) is an aggressive nervous system tumor with a mean survival time of 12-14 months. Cells with neural stem cell-like properties can be derived from GBM tumors. These cells seem to escape conventional irradiation treatment, chemotherapy, and surgery, and may play a crucial role for relapse. It is therefore urgent to develop novel approaches for reliable detection of neural stem cell-like cells in GBM. Here we report a luminescent conjugated oligothiophene (LCO), named GlioStem (p-HTMI), for non-invasive and non-amplified real-time detection of live human patient-derived

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Byazrova, M. G., A. P. Toptygina, T. A. Mitina, and A. V. Filatov. "Gating strategy for plasmablast enumeration after hepatitis B vaccination." Medical Immunology (Russia) 22, no. 6 (2021): 1185–94. http://dx.doi.org/10.15789/1563-0625-gsf-2066.

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B cell stimulation develops upon vaccination, thus causing occurrence of activated B cells (plasmoblasts) in bloodstream. Similar cells are also observed in some viral infections. The contents of plasmablasts may be a marker of successful vaccination, or a diagnostic feature of ongoing infection. The plasmablasts are normally represented by a small cell subpopulation which is not easy to detect. A study was performed with 15 healthy volunteers who were subjected to a single immunization with a recombinant vaccine against hepatitis B virus. To identify the plasmablasts, we have used labeled ant

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Gao, Zhikui, Hui Liu, Yajuan Shi, Lihong Yin, Yong Zhu, and Ran Liu. "Identification of Cancer Stem Cell Molecular Markers and Effects of hsa-miR-21-3p on Stemness in Esophageal Squamous Cell Carcinoma." Cancers 11, no. 4 (2019): 518. http://dx.doi.org/10.3390/cancers11040518.

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Cancer stem cells (CSCs) are closely related to tumor resistance and tumor recurrence in esophageal squamous cell carcinoma (ESCC). The lack of specific biomarkers to identify and isolate CSCs has led to the slow progression of research on CSCs in ESCC. Here, we established a method to identify and isolate CSCs in ESCC using fluorescence-activated cell sorting with combined surface biomarkers including CD71, CD271, and CD338. CD71−/CD271+/CD338+ subpopulation cells possessed more stem cell properties in proliferation, self-renewal, differentiation, metastasis, drug resistance, and tumorigenesi

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Leprince, C., S. Cohen-Kaminsky, S. Berrih-Aknin, et al. "Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis." Journal of Immunology 145, no. 7 (1990): 2115–22. http://dx.doi.org/10.4049/jimmunol.145.7.2115.

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Abstract Thymic cell populations from 12 patients displaying myasthenia gravis were submitted to a phenotypic and functional study. Immunofluorescence analysis of thymic sections revealed the presence in germinal centers of B lymphocytes expressing the B cell markers--CD19, CD21, IgD, or IgM. After T cell and macrophage depletion of thymic single cell suspensions, B cell-enriched populations were isolated. Enriched B cells expressed at variable levels activation markers such as CD71, 4F2, CD23, and B8.7, indicating that a marked proportion of them are activated. Moreover, addition of B cell gr

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Mohanty, Atish, Michelle Afkhami, Amanda Reyes, et al. "Exploring markers of immunoresponsiveness in papillary thyroid carcinoma and future treatment strategies." Journal for ImmunoTherapy of Cancer 12, no. 7 (2024): e008505. http://dx.doi.org/10.1136/jitc-2023-008505.

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BackgroundThe study summarizes the potential use of immunotherapy forBRAF-mutated papillary thyroid cancer (PTC) by analyzing the immune profile of City of Hope PTC patient samples and comparing them to the thyroid dataset available in the TCGA database.Materials and methodsPTC cases with available formalin-fixed paraffin-embedded archived tumor tissue were identified. RNA was extracted from the tumor tissue and analyzed by NanoString to evaluate their immune gene expression profile. Immunohistochemistry was used to determine the expression of immune suppressive genes and lymphocytic infiltrat

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Lichtenegger, Felix S., Katharina Mueller, Wolfgang Hiddemann, Dolores J. Schendel, and Marion Subklewe. "Dendritic Cells Matured with a TLR7/8 Agonist Induce T Helper 1 Cell Polarization, Activate NK Cells and Are Thus Highly Suitable for Application in Cancer Immunotherapy." Blood 118, no. 21 (2011): 358. http://dx.doi.org/10.1182/blood.v118.21.358.358.

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Abstract Abstract 358FN2 Dendritic cells (DCs) are important regulators of the human immune response. By means of direct intercellular interactions and secretion of cytokines, they can induce a stimulatory or a regulatory response, depending on the environment in which they developed. In vitro, it is possible to imitate this process by addition of various cytokines. The aim of this study was to evaluate DCs matured by different cytokine cocktails for expression of immunostimulatory and -inhibitory molecules and correspondent activation of T helper 1 (Th1) and natural killer (NK) cells. The sel

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