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Dissertations / Theses on the topic 'CD30L T cell'

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1

Mühle, Kerstin. "Interaction of CD8+CD40L+ T cells with B cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19127.

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ZTLs vermitteln die Eliminierung von infizierten und entarteten Zellen durch Apoptose. Neuste Erkenntnisse unserer Gruppe haben gezeigt, dass eine Subpopulation der CD8+ T-Zellen, anstelle der zytotoxischen Marker das Oberflächenmolekül CD40L exprimiert. Die Expression von CD40L ist bislang als Schlüsselmolekül für die CD4+ T-Zell vermittelte Hilfe bekannt, welche durch Bindung an den CD40 Rezeptor auf anderen Immunzellen induziert wird. Das von den CD4+ T–Zellen ausgehende CD40L Signal ist besonders für die T-Zell abhängige B-Zell Aktivierung und die Bildung von Keimzentren essentiell, in den
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2

Abduh, Maisa. "Follicular CD4 T Cells Tutor CD8 Early Memory Precursors : an Initiatory Journey to the Frontier of B Cell Territory." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS371.

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Les lymphocytes T CD8+ spécifiques de l'antigène sont impliqués dans la réponse immunitaire adaptative et jouent un rôle essentiel dans la protection de l'hôte contre l'infection par des pathogènes intracellulaires. Cette protection de longue durée dépend de la génération de réponses lymphocytaires T CD8+ mémoires, hautement fonctionnelles en termes de fréquence et de fonctionnalité, après réinfection.Après présentation de l'antigène, une cellule T CD8 naïve subit une forte expansion clonale, générant une population hétérogène de cellules activées qui est dominée, au sommet de l'expansion, par
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3

Loyal, Lucie. "The molecular regulation of CD40L in CD8+ T cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20158.

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T Zellen können in zwei Hauptpopulationen mit unterschiedlichen Aufgaben unterschieden werden. CD4+ T Zellen exprimieren im Zuge ihrer Aktivierung CD40L, welches ein zentraler kostimulatorischer Rezeptor zur Induktion von B-Zell basierter humoraler Immunität, APC Aktivierung und einer effizienten Effektor CD8+ T Zell Entwicklung ist („Helfer-Funktion“). Im Gegensatz dazu sind die zytotoxischen CD8+ T Zellen dazu vorbestimmt, infizierte oder maligne Zellen direkt abzutöten. Jedoch wurde eine Fraktion von CD8+ T Zellen identifiziert, die nach Aktivierung CD40L exprimiert. Bisher ist nicht versta
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4

Hirano, Ayumi. "T dependent B cell help in cattle : immunoregulatory function of interleukin-4 and CD40-CD40L interactions /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841150.

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5

Schubert, Lisa Ann. "Characterization of the transcriptional regulation of the human CD40L gene in CD4 T cells /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8325.

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6

Mühle, Kerstin [Verfasser], Hans-Dieter [Gutachter] Volk, Andreas [Gutachter] Thiel, and Ulf [Gutachter] Wagner. "Interaction of CD8+CD40L+ T cells with B cells / Kerstin Mühle ; Gutachter: Hans-Dieter Volk, Andreas Thiel, Ulf Wagner." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185495924/34.

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7

Loyal, Lucie [Verfasser], Andreas [Gutachter] Thiel, Chiara [Gutachter] Romagnani, and Hans-Dieter [Gutachter] Volk. "The molecular regulation of CD40L in CD8+ T cells / Lucie Loyal ; Gutachter: Andreas Thiel, Chiara Romagnani, Hans-Dieter Volk." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1190641046/34.

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8

Harlin, Helena. "TRAF4 and CD30/TRAF2 in normal T cell function /." 2001. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3019923.

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9

Chen, Jui-Chieh, and 陳瑞傑. "The inhibition of T cell proliferation by CD30 expression on the Hodgkin’s cancer cell." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/49838763617401022976.

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碩士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>91<br>英文摘要 Hodgkin''s disease is a type of malignant lymphoma, characterized by the presence of abnormal cells, named Reed-Sternberg cells, in patient’s lymph nodes. CD30 was originally described as a marker of Hodgkin/Reed-Sternberg cells. CD30 and its cognate ligand, CD153, belong to members of the TNFR and TNF superfamilies, respectively. CD30 is expressed on the surface of Hodgkin/Reed-Sternberg (H-RS) cell lines (KM-H2), while expression of CD153 can be induced on the surface of peripheral blood T cells by anti-CD3 or PHA activation. In this st
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10

Boyle, Julia Katrina. "The role of CD30 in the regulation of T cell function." Thesis, 2003. http://hdl.handle.net/2429/14546.

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CD30 is a member of the TNFR superfamily that was initially identified on Reed-Sternberg cells of Hodgkin's disease and is widely expressed in other lymphomas as well as in a number of autoimmune diseases. On normal cells, CD30 is expressed primarily on activated CD8⁺ T cells and is induced by two distinct pathways, an IL-4 dependent pathway and an IL-4-independent pathway via CD28. The precise role of CD30 has been controversial, but it has been implicated in a number of T cell functions, including costimulation, cytokine production, cell survival and cytotoxicity, although much of the publis
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11

Snell, Laura Margaret Lucette. "The Role of TNFR Family Members GITR and CD30 on CD8 T Cell Responses." Thesis, 2012. http://hdl.handle.net/1807/36299.

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GITR and CD30 are T cell costimulatory members of the TNFR superfamily known to regulate T cell responses. Elucidating the mechanisms whereby these receptors modulate T cell responses is crucial for maximizing their potential for immunotherapy. In this thesis, I examine the role of GITR and CD30 on CD8 T cell responses to influenza virus. I show that CD8 T cell intrinsic GITR is required for both maximal primary and secondary CD8 T cell expansion to influenza, while in contrast, CD30 is dispensable for anti-influenza CD8 T cell responses. GITR does not impact on CD8 T cell proliferation or hom
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12

Lo, Yun, and 羅筠. "Phenotypic and Functional Analyses of Human CD40L-expressing Regulatory T cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/83399u.

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碩士<br>國立臺灣大學<br>免疫學研究所<br>106<br>Regulatory T cells are first discovered to regulate immune response through suppression to other immune cells. Upon facing environmental stimuli, it has been suggested that Treg cells show adaptive properties, even reported to provide a helper function in a mouse model. However, little is unknown about the helper activity of human Treg cells. The aims of this study are to identify human CD40L-expressing Treg cells along with their phenotypic and functional characteristics. In this study, we isolated human Treg cells from healthy donors and identified CD40L-expr
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13

Naddaf, Nadim. "Le rôle biologique de l’interaction du CD40L avec l’intégrine α5β1 des lymphocytes T". Thèse, 2012. http://hdl.handle.net/1866/8734.

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Le CD40 ligand (CD40L) est un régulateur important de la réponse immunitaire et un contributeur clé dans les maladies auto-immunes. Nous avons rapporté précédemment que le CD40L se liait à l’intégrine α5β1, toutefois, les conséquences fonctionnelles de cette interaction demeurent inconnues. Les lymphocytes T sont au centre de la pathogénèse des maladies auto-immunes. Ils expriment, lors de celles-ci, des quantités aberrantes d’intégrines β1 faisant en sorte que la liaison CD40L/α5β1 pourrait être d’une haute importance dans les réponses inflammatoires. Dans cette étude, nous avons démontré que
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14

Awe, Olufolakemi O. "Transcription factor regulation of T helper subset function." 2015. http://hdl.handle.net/1805/7342.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The immune system protects the body from foreign organisms. T cells and B cells are integral components of the ability of the immune system to generate focused immune responses. The development of specialized subsets of T helper cells is governed by transcription factors. Previous work demonstrated a requirement for the transcription factor PU.1 in the development of IL-9-secreting Th9 cells. Work in this dissertation demonstrates that the Th9 subset is not stable in vitro, and that PU.1 expression decreases during long-term culture.
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15

"THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY." Thesis, 2012. http://hdl.handle.net/10388/ETD-2012-04-424.

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The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help for CD8+ cytotoxic T lymphocyte (CTL) responses in different immunization types. The establishment of diseases, such as chronic infections and cancers, is attributed to severe loss of or dysfunctions of CD4+ T cells. Even in acute infections, CD4+ T cell deficiency leads to poor memory responses. While the role of CD4+ T cells is being increasingly appreciated in these diseases, the timing and nature of CD4+ T help and associated molecular mechanisms are not completely understood. Growing eviden
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