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Dissertations / Theses on the topic 'CD31 regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Merchand, Reyes Giovanna. "Targeting myeloid cells as a potential Chronic Lymphocytic Leukemia therapeutic strategy." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595259890785332.

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2

Zeng, Fanli. "Novel Modes of Regulation of Cyclin Dependent Kinase Cdk1." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/133357.

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Les quinases dependents de ciclina (CDKs) dirigeixen la progressió del cicle cel·lular a les cèl·lules eucariotes. A l’organisme eucariota model Saccharomyces cerevisiae (llevat de gemmació) una sola quinasa dependent de ciclina, Cdk1, és essencial i suficient per dirigir el cicle cel·lular. Unida alternativament a ciclines de fase G1, S i G2/M, Cdk1 regula els programes transcripcionals del cicle cel·lular, la replicació i segregació dels cromosomes, la dinàmica del fus mitòtic, el creixement cel·lular polar, la morfogènesi, etc. La desregulació de l’activitat CDK promou la proliferació

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3

Orr, S. J. "Regulation of expression and function of CD33-related siglecs." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432514.

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4

Woodbury, Erika L. "Regulation of spindle stability by Cdk1 and the APC." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261256.

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5

Marr, Helen Judith. "Regulation of CD38 by IRF4 in chronic lymphocytic leukemia." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3244.

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Genome‐wide association analysis identified rs872071, a common variant in the 3’UTR of IRF4, as tagging a risk allele for chronic lymphocytic leukaemia (CLL). The risk allele is significantly associated with expression of CD38, a poor prognostic marker in CLL. IRF4 is a transcription factor with pleiotropic roles in the regulation of B cell development, and interrogation of the CD38 gene identified a number of putative binding sites for IRF4, suggesting that CD38 may be transcriptionally regulated by IRF4. Chromatin immunoprecipitation (ChIP) demonstrated significant IRF4‐CD38 binding at two c

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6

Ho, Desiree Shulin. "Transcriptional regulation of the human CD30 gene through an intronic enhancer." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0026.

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Lymphomas are neoplasms of the human immune system and can be divided into two categories, Hodgkins lymphoma (HL) and non-Hodgkin lymphoma (NHL). Anaplastic large cell lymphoma (ALCL) is a form of NHL that shares a common distinctive feature with HL, the overexpression CD30. The expression of cytokine receptor CD30 is restricted to proliferating B and T lymphocytes in healthy individuals while its overexpression is associated with several lymphoproliferative diseases such as ALCL and HL. The activation of CD30 via ligand or antibodies triggers various cellular responses ranging from apoptosis

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7

Soni, Deena. "Studies on regulation of mitotic transition by cyclin B1/CDK1." Connect to text online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1099070698.

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Thesis (Ph. D.)--Case Western Reserve University, 2005.<br>[School of Medicine] Department of Environmental Health Sciences. Includes bibliographical references. Available online via OhioLINK's ETD Center.

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8

McCann, N. M. "A role for SOCS3 in regulating CD33 function." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426665.

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9

Date, Dipali A. "Regulation and Post-translational modifications of Borealin." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1279127511.

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10

Gillingham, Helen. "Role and regulation of aminopeptidase N (CD13) in HT1080 fibrosarcoma cells." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610322.

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11

Soni, Deena V. "Studies on the regulation of mitotic transition by cyclin B1/Cdk1." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1099070698.

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12

Woodhouse, Laura. "Regulation of the DNA licensing protein Cdt1 in Xenopus laevis embryos." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2500.

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During each cell cycle the DNA must be replicated accurately in order to maintain genomic integrity. To ensure faithful replication of the entire genome, DNA replication must be tightly controlled. This control is achieved through the process of DNA licensing in which pre-replicative complexes are assembled to prime the DNA for replication in the coming S-phase. To prevent re-licensing and subsequent re-replication, which would lead to genomic instability, DNA licensing must also be tightly controlled. The main mechanism of regulation of DNA licensing is through regulation of Cdt1 activity, a

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13

Daniels, Brodie Belinda. "Molecular and cellular analysis of the interaction between soluble CD23 and CD11/CD18 integrins." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1217.

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The low affinity IgE receptor, CD23, is expressed by a wide variety of cells and cleaved from its original 45 kDa size to several smaller soluble CD23 proteins. Soluble CD23 function depends on the form of the protein and its interaction with various ligands. CD23 is believed to play an important role in regulating allergic responses and in inflammation, amongst others. β2 integrins are important in a variety of cell-adhesion reactions during immune-inflammatory mechanisms and the binding of their natural ligands generates outside-in cellular signalling, leading to cell activation. Although th

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14

Almoflehi, Sakhar. "Cord Blood CD34+ Expansion Using Vitamin-C: An Epigenetic Regulator." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41413.

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Vitamin-C (Vit-C) has been shown to modulate hematopoietic stem cells and leukemia stem cell frequency in-vivo. Herein, Vit-C analogue, L-ascorbic acid 2-phosphate (AA2P), was investigated as a new potential HSC expansion agonist. Cord blood CD34+ cells were expanded in cultures with or without AA2P. AA2P induced a 2-fold increase in the expansion of stem and progenitor subsets including lymphoid-primed multi-potential progenitors (p<0.05, n=3) and functional colony forming progenitors. The functional properties of AA2P grafts was evaluated with a xenotransplant model. Superior platelet levels

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15

Lee-Prudhoe, J. E. "The genomic structure and regulation of murine CD33 : a marker of erythromyeloid commitment." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249473.

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16

Shepherd, Marianne E. A. "The cell cycle and DNA damage-dependent regulation of Cdt1 in schizosaccharomyces pombe." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:7f2ebafb-7d0d-4c0d-b6a6-277025f71850.

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Cdt1 is a conserved and essential eukaryotic protein that is required for the licensing step of DNA replication. In order to control replication licensing and ensure a single round of DNA replication occurs per cell cycle, Cdt1 is subject to strict regulation. In Metazoa and S. pombe, Cdt1 is targeted for ubiquitylation and proteolysis in S phase and after DNA damage by the CRL4Cdt2 ubiquitin ligase. CRL4Cdt2 is activated in Metazoa by an unusual mechanism that requires an interaction between the substrate and chromatin-loaded proliferating cell nuclear antigen (PCNA). This study addressed the

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17

Lindsey, Madison L. "The Impact of FoxO1 Overexpression on the Regulation of CD36 in Skeletal Muscle." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525425389232742.

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18

Chu, Ling-yun. "The Role of CD36 in Thrombospondin-1 Mediated Antiangiogenesis: A Study of Regulation of CD36 Ecto-phosphorylation and Mechanisms of VEGF Inhibition." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1332332261.

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19

David, Alain. "Exploring the Regulation of Mitotic PP2A-Rts1 Activity in Saccharomyces cerevisiae." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42437.

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Protein phosphorylation is an essential post-translational modification used in cells for regulating multiple biological processes in all organisms. Particularly, mitotic onset is regulated in all eukaryotes by an increase in cyclin-dependent kinase 1 (Cdk1) activity caused by the dephosphorylation of Cdk1 on a conserved tyrosine residue. PP2ARts1 is a phosphatase that participates in dephosphorylating the conserved tyrosine residue, tyrosine-19 (Y19). PP2ARts1 dephosphorylates phosphorylated serine and threonine residues. However, in vitro experiments suggest that in conjunction with the mamm

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20

Cruickshank, Mark. "Analysis of CR2/CD21 transcriptional regulation by chromatin structural variation and notch activity in human cell models." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0115.

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[Truncated abstract] Human complement receptor 2 (CR2/CD21) is a cell surface glycoprotein detected on specific cells involved in immunity, which binds complement C3 cleavage fragments, cellular ligands IFN-? and CD23 as well as the EBV coat protein, gp350/220. During the early stages of B-cell development CR2/CD21 is silenced. Expression is initiated on immature B-cells escaping negative selection. During peripheral maturation CR2/CD21 is up-regulated with B-cell sub-populations showing distinctive surface levels (comparatively low, intermediate or high). CR2/CD21 is silenced upon terminal pl

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21

Aggarwal, Reeva. "Mechanisms of Human CD34+ Stem Cell-Mediated Regulation of Osteoporosis in a Preclinical Model." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354637444.

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22

Hull, Lynn. "Enzymatic Regulation of Opioid Antinociception and Tolerance." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1875.

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ENZYMATIC REGULATION OF OPIOID ANTINOCICEPTION AND TOLERANCE By Lynn C. Hull, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Director: William L. Dewey, Ph.D. Department of Pharmacology and Toxicology The involvement of kinases in opioid actions has long been established. The acute actions of opioids, through the Gi/Go G-proteins, cause the inhibition of adenylyl cyclase and therefore a decrease in protein kinase A (PKA) activation. A

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23

Jha, Vibha. "Cellular regulation of mercury-induced autoimmunity." Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/60597.

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Microbiology and Immunology<br>Ph.D.<br>Etiological agents causing autoimmune diseases largely remain unknown. However, several lines of evidence suggest that environmental factors such as heavy metals (arsenic, lead and mercury) play a crucial role in the development of autoimmune disorders. In our model of mercury-induced autoimmunity, administration of subtoxic doses of HgCl2 to genetically susceptible strains of mice result in an autoimmune disease characterized by the production of highly specific anti-nucleolar autoantibodies, hypergammaglobulinemia and nephritis. However, mice can

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24

Ji, Jun-Yuan. "Functions of Cdk1-cyclin B in regulating the early embryonic mitoses in Drosophila /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5124.

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25

Bossennec, Marion. "Caractérisation et régulation des lymphocytes T CD4+CD73+ en contextes physiologique et pathologique." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1159.

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L'étude des populations de lymphocytes T CD4+ effecteurs (Teff) chez l'Homme présente un intérêt croissant dans les enjeux actuels que constitue l'élaboration de nouvelles immunothérapies. Ces travaux détaillent la caractérisation et la régulation d'une population de Teff exprimant l'ecto-nucléotidase CD73 ayant pour fonction de dégrader l'AMP extracellulaire en adénosine (Ado) immunosuppresseur. Cette population, enrichie en lymphocytes T helper de type Th1.17, est très polyfonctionelle et pro-inflammatoire. Les Teff CD73+ expriment peu de points de contrôles immunitaires inhibiteurs mais son

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26

Havens, Courtney Guiheen. "Regulation of late G1/S phase transition and the anaphase promoting complex-Cdh1 by reactive oxygen species /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3236627.

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27

Riemann, Dagmar Ute. "Arbeiten zum Vorkommen und zur Regulation von Aminopeptidase N/CD13 mit besonderer Berücksichtigung ihres Vorkommens auf Lymphozyten." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965575055.

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28

King, A. A. A. "Transcriptional programmes of haemopoietic stem cells: regulation of the gene encoding the murine stem cell antigen Cd34." Thesis, Institute of Cancer Research (University Of London), 2000. http://publications.icr.ac.uk/9717/.

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Haemopoietic stem cells are capable of self-replicating and differentiating along eight distinct lineages; these properties allow them to reconstitute the entire blood system of irradiated recipients. How these cells choose whether to self-renew or commit to a specific lineage remains unclear, but transcription factors are likely to play an important role in this decision. To gain insight into the transcriptional programmes of haemopoietic stem cells, the regulation of the gene encoding the murine stem cell antigen Cd34 was analysed. Within haemopoiesis, Cd34 expression is restricted to early

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29

Martin, Céline. "Détection gustative des lipides alimentaires chez la souris : portrait croisé de deux lipido-récepteurs, CD36 & GPR120 : impacts sur les préférences alimentaires et la santé." Thesis, Dijon, 2011. http://www.theses.fr/2011DIJOS077.

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Certains mammifères, dont l’Homme, ont une forte attraction pour les lipides alimentaires. Pendant longtemps, il était admis que ces nutriments étaient détectés uniquement via leurs propriétés olfactives, texturales et post-ingestives. Cependant, l’existence d’une dimension gustative a été suggérée depuis. Dans ce contexte, notre Laboratoire a démontré que la glycoprotéine CD36 exerçait une fonction de lipido-récepteur gustatif impliquée à la fois dans la préférence spontanée pour les lipides alimentaires et la phase céphalique de la digestion induite par la présence de lipides au niveau oral

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30

Joshi, Shrinidh Ashokkumar. "Hypoxic Regulation of Angiotensin-Converting Enzyme 2 and Mas Receptor in Hematopoietic Stem/Progenitor Cells: A Translational Study." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/28961.

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Vascular disease is the leading cause of mortality and morbidity in the western world, and account for the 1 of every 3 death?s in the US, but a cure for vascular disease is yet to be realized. Hematopoietic stem progenitor cells (HSPCs) are mobilized from bone marrow and have the innate propensity to accelerate vascular repair by reendothelialization and revascularization of ischemic areas. The vasoreparative ability of HSPCs is largely due to their capacity to home to the areas of hypoxia and their sensitivity to hypoxia plays a critical role in the vasoreparative functions of these cells. T

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31

Braun, Alexander [Verfasser], and Florian [Akademischer Betreuer] Haller. "Charakterisierung der epigenetischen Regulation der Glykoproteine „Hematopoietic progenitor cell antigen CD34“ und „Prominin-1“ in gastrointestinalen Stromatumoren (GIST)." Freiburg : Universität, 2016. http://d-nb.info/1120020808/34.

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32

Chien, Wei Wen. "p16INK4a, régulation du cycle cellulaire et microARN." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10183.

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L’inhibition, par p16INK4a, de la progression du cycle cellulaire est considérée comme liée à un arrêt de la progression en phase G1 du à l’inhibition de l’activité de CDK4/6. Nous montrons que l’expression ectopique de p16INK4a dans trois lignées cellulaires malignes, p16-/- et pRb+/+, issues de tissus différents, provoque un allongement de la durée de la phase S et du cycle cellulaire total. L’ensemble de nos travaux sur p16INK4a sauvage et son mutant p16G101W indique que p16INK4a induit un allongement de la phase S i) indépendamment de l’origine tissulaire des cellules analysées et ii) en p

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33

Son, Sunghun. "Systematic analysis of phosphatase genes in aspergillus nidulans and a role of FCP1 in cell cycle regulation." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1196228508.

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34

Yanow, Stephanie Kim. "Regulation of Cdc18 and Cdt1 restricts S phase to once per cell cycle in the fission yeast Schizosaccharomyces pombe." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251716.

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35

Bhaduri, Samyabrata. "Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/871.

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Several cell cycle events require specific forms of the cyclin-CDK complexes. It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. There are several examples of B-type cyclins identifying certain peptide motifs in their specific substrates through a conserved region in their structure. Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant wi

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36

Dahlström, Jörgen. "Feedback Enhancement of Antibody Responses via Complement and Fc Receptors." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-597.

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<p>IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for IgG (FcγRI, FcγRII and FcγRIII) and complement receptors 1 and 2 (CR1/2) for antibody-mediated enhancement of antibody responses are investigated.</p><p>IgM is known to efficiently activate complement and thereby enhance specific antibody responses but it is not known if this involves binding to CR1/2. Using CR1/2 deficient mice, immunized with sheep erythrocytes alone or together with specific IgM, we present evidence that IgM-mediated enhanc

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37

Böttger, Franziska [Verfasser], and Olaf [Akademischer Betreuer] Stemmann. "Eukaryotic chromosome segregation: New aspects of separase regulation by securin, Cdk1, PP2A and auto-cleavage / Franziska Böttger. Betreuer: Olaf Stemmann." Bayreuth : Universität Bayreuth, 2011. http://d-nb.info/105990859X/34.

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38

Chaffee, Blake Richard. "Cell Cycle Regulation and Cellular Differentiation in the Developing Ocular Lens." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1437562575.

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39

Chevrot, Michaël. "Impact de l'obésité sur la détection oro-sensorielle des lipides alimentaires chez la souris et chez l'Homme." Phd thesis, Université de Bourgogne, 2013. http://tel.archives-ouvertes.fr/tel-00967824.

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La gustation est une composante essentielle de la détection oro-sensorielle des lipides alimentaires. La liaison des AGLC sur le récepteur CD36 joue un rôle prépondérant dans cette lipido-détection orale chez la souris et très probablement chez l'Homme. En effet, elle intervient dans le choix alimentaire (sensibilité aux lipides) ainsi que dans la préparation de l'organisme à l'arrivée de lipides. Ce " sensing " oral des lipides est fortement régulé. Comme l'obésité semble être responsable d'une altération de la détection des saveurs primaires, l'objectif de cette thèse a été d'explorer si l'o

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40

Wulfänger, Jens [Verfasser], Sven Erik [Akademischer Betreuer] Behrens, Barbara [Akademischer Betreuer] Seliger, and Dirk [Akademischer Betreuer] Reinhold. "Neue Aspekte in der Regulation und in der Funktion von Aminopeptidase N (APN)/ CD13 und Ubiquitin-Carboxy-terminale Hydrolase L1 (UCHL1) / Jens Wulfänger. Betreuer: Sven Erik Behrens ; Barbara Seliger ; Dirk Reinhold." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2014. http://d-nb.info/1060367505/34.

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GAUFFRE, ALINE. "Contribution a l'analyse des interactions intracellulaire du recepteur pour le virus d'epstein-barr (ebv) et pour le c3d (cr2, cd21), implique dans la regulation de la proliferation des lymphocytes b humains." Paris 7, 1992. http://www.theses.fr/1992PA077067.

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Le cr2 est le recepteur pour le virus d'epstein-barr et pour le c3d, fragment du troisieme composant du complement humain. Le cr2 est implique dans la regulation de la proliferation des lymphocytes b humains. Il a ete montre que, dans le cas des cellules transformees raji, le cr2 interagit in vitro avec l'anti-oncoproteine p53 et la ribonucleoproteine p120rnp. De plus le cr2 phosphoryle a ete detecte dans les noyaux des cellules raji. Au cours de ce travail nous avons precise la localisation nucleaire de cr2 dans les noyaux des cellules raji. Et nous avons montre que dans les lymphocytes b nor

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Martius, Gesa [Verfasser], Giuliano [Akademischer Betreuer] Ramadori, Wolfgang [Akademischer Betreuer] Engel та Wilfried [Akademischer Betreuer] Kramer. "Effect of radiation on hepatic fat metabolism in rat and mouse: A role of radiation-induced TNF-α in the regulation of FAT/CD36 / Gesa Martius. Gutachter: Wolfgang Engel ; Wilfried Kramer. Betreuer: Giuliano Ramadori". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1075372909/34.

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Mueller, Christian. "Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/595.

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Background: Cystic fibrosis (CF) remains the most common fatal monogenic disease in the US, affecting 1 in 3,300 live births. CF is the result of mutations in CFTR, a chloride channel and regulator of other ion channels. The mechanisms by which CFTR mutations cause chronic lung disease in CF are not fully defined, but may include the combined effects of altered ion and water transport across the airway epithelium and aberrant inflammatory and immune responses to pathogens within the airways. We have shown that Cftr-/- mice mount an exaggerated IgE response towards Aspergillus fumigatus (Af) w

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44

DRANE, PASCAL. "Contribution a l'analyse moleculaire du role du recepteur pour le virus d'epstein-barr et pour le c3d (cr2, cd21) dans la regulation des lymphocytes b humains : identification de rb18a, une nouvelle proteine qui regule des fonctions de la p53." Paris 6, 1997. http://www.theses.fr/1997PA066646.

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Le cr2 (cd21, ebv/c3dr) est une glycoproteine membranaire impliquee dans l'activation et la proliferation des lymphocytes b. C'est le recepteur pour le virus epstein-barr (ebv) et le c3d, dernier fragment genere lors de l'activation du c3. Le domaine intracytoplasmique du cr2 interagit avec la proteine suppresseur de tumeur p53 dans les lymphomes de burkitt et avec l'annexine vi dans les lymphocytes b normaux. Nous avons identifie une nouvelle proteine p45 qui interagit avec le domaine intracytoplasmique du cr2. L'expression de p45 est induite lors de l'infection de lymphocytes b par l'ebv. Ce

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45

Lau, Jonathan. "Investigating the role of human cytomegalovirus protein LUNA in regulating viral gene expression during latency." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/280253.

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Human cytomegalovirus (HCMV) is a widespread human herpesvirus pathogen and prototypical member of the β-herpesvirus subfamily. Like all herpesviruses, the virus establishes a lifelong latent infection following host exposure, which has the potential to reactivate periodically and contribute to recurrent disease processes. In individuals with weak or compromised immune systems, such reactivation can lead to profound pathology. Understanding how latent infections are maintained is important for uncovering how HCMV causes disease. The study of viral genes that are expressed during latent infecti

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46

Ubersax, Jeffrey A. "Cell-cycle regulation by Cdk1 in Saccharomyces cerevisiae /." 2004. http://wwwlib.umi.com/dissertations/fullcit/3149703.

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47

Waugh, Caryll Marie. "Prothymosin alpha, a gene differentially expressed in CD34+ cells." 2004. http://repository.unimelb.edu.au/10187/1028.

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Haemopoietic stem and progenitor cells from bone marrow and cord blood are well characterised with respect to their phenotype, growth in clonal assays, responsiveness to cytokine stimulation, receptor profile and their ability to sustain multilineage engraftment of receptive hosts in animal models of transplantation and of course, clinically in the treatment of some haemopoietic and immunological disorders. It is generally accepted that cells bearing the CD34+ phenotype are enriched for the most primitive of haemopoietic stem cells that possess the cardinal features of self-renewal and multip

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48

Anderson, Christopher R. "Cellular regulation and functional significance of differential CD36 expression during angiogenesis /." 2007. http://wwwlib.umi.com/dissertations/fullcit/3282872.

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49

Jhang, Jia-Cin, and 張嘉琴. "Cdk1-mediated Bud3 regulation of bud site selection in Saccharomyces cerevisiae." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/38784838784991602545.

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碩士<br>臺灣大學<br>微生物學研究所<br>98<br>Cdc28 is well-known as the catalytic subunit of main cyclin- dependent kinase, whose activity associates with different substrates would drive events through cell cycle. Many substrates of Cdc28 have been reported, such as Sic1, Cln2, and Swi5…, etc. The protein phosphatase, Cdc14, required for mitotic exits. With anaphase onset, Cdc14 released from nucleolus by FEAR network and mitotic exit network, which enable a decrease in Cdk-Clb activity. Therefore, we wondered if there any unknown substrates of Cdc28 would be found. We had compared the phosphorylation leve

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Boyle, Julia Katrina. "The role of CD30 in the regulation of T cell function." Thesis, 2003. http://hdl.handle.net/2429/14546.

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CD30 is a member of the TNFR superfamily that was initially identified on Reed-Sternberg cells of Hodgkin's disease and is widely expressed in other lymphomas as well as in a number of autoimmune diseases. On normal cells, CD30 is expressed primarily on activated CD8⁺ T cells and is induced by two distinct pathways, an IL-4 dependent pathway and an IL-4-independent pathway via CD28. The precise role of CD30 has been controversial, but it has been implicated in a number of T cell functions, including costimulation, cytokine production, cell survival and cytotoxicity, although much of the publis

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