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Journal articles on the topic 'CD31 regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Wang, Zack Z., Hao Bai, YongXing Gao, Melanie Arzigian, Don M. Wojchowski, and Wen-shu Wu. "BMP Signaling Is Crucial for Regulation Vascular Progenitor Development in Human Embryonic Stem Cells." Blood 114, no. 22 (2009): 3037. http://dx.doi.org/10.1182/blood.v114.22.3037.3037.

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Abstract Abstract 3037 Poster Board II-1013 The generation of vascular cells from pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells, may facilitate tissue transplantation, reperfusion of ischemic tissues, and treatment of pathologies in which endothelial cell dysfunction exists. The signals that direct pluripotent stem cell differentiation into lineage-specific cells remain largely unknown. To identify vascular progenitor cells during hESC differentiation, we characterized various subpopulations that may differentiate into endothelial

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2

DeLeve, Laurie D., Xiangdong Wang, Liping Hu, Margaret K. McCuskey, and Robert S. McCuskey. "Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation." American Journal of Physiology-Gastrointestinal and Liver Physiology 287, no. 4 (2004): G757—G763. http://dx.doi.org/10.1152/ajpgi.00017.2004.

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The phenotypic features of liver sinusoidal endothelial cells (SEC), open fenestrae in sieve plates and lack of a basement membrane, are lost with capillarization. The current study examines localization of CD31 as a marker for the dedifferentiated, nonfenestrated SEC and examines regulation of SEC phenotype in vitro. CD31 localization in SEC was examined by confocal microscopy and immunogold-scanning electron microscopy. SEC cultured for 1 day express CD31 in the cytoplasm, whereas after 3 days, CD31 is also expressed on cell-cell junctions. Immunogold-scanning electron microscopy confirmed t

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3

Boquest, A., A. Shahdadfar, K. Fronsdal, J. Brinchmann, and P. Collas. "167 ISOLATION AND COMPARATIVE PROFILING OF HUMAN ADIPOSE-DERIVED ADULT STEM CELLS." Reproduction, Fertility and Development 17, no. 2 (2005): 234. http://dx.doi.org/10.1071/rdv17n2ab167.

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The stromal compartment of mesenchymal tissues is thought to harbor stem cells that display extensive proliferative capacity and multilineage potential. However, despite their potential impact in the field of regenerative medicine, little is known about the biology of stromal stem cells prior to culture. After removing adipocytes and erythrocytes from collagenase digested human adipose tissue, we identified two cell populations using flow cytometry which shared expression of stem cell markers SH2 and CD34, but lacked the phenotypic characteristics of leukocytes (CD45−). However, they were foun

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4

Romano, Eloisa, Irene Rosa, Bianca Saveria Fioretto, et al. "A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells." International Journal of Molecular Sciences 21, no. 16 (2020): 5877. http://dx.doi.org/10.3390/ijms21165877.

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Telocytes (TCs), commonly referred to as TCs/CD34+ stromal cells, are a peculiar type of interstitial cells with distinctive morphologic traits that are supposed to exert several biological functions, including tissue homeostasis regulation, cell-to-cell signaling, immune surveillance, and reparative/regenerative effects. At present, the majority of studies investigating these cells are mainly descriptive and focus only on their morphology, with a consequent paucity of functional data. To gain relevant insight into the possible functions of TCs, in vitro analyses are clearly required, but curr

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Qiu, Jiajing, Xiaoli Wang, Mohamed E. Salama, and Ronald Hoffman. "Characterization and Isolation of Splenic Littoral Cells, a Possible Cellular Niche for Extramedullary Hematopoiesis in Myelofibrosis." Blood 126, no. 23 (2015): 3594. http://dx.doi.org/10.1182/blood.v126.23.3594.3594.

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Abstract Splenic littoral cells (LC) line the venous sinusoids of the human spleen and have been thought to act as blood cells filters. Little is known about SLCs beyond their preliminary characterization using immunochemistry and electron microscopy by others. Since SLCs comprise a significant portion of spleen, we hypothesized that SLC might be an important component of the splenic microenvironment that contributes to the development of extramedullary hematopoiesis in myelofibrosis (MF) patients. To further phenotypically characterize viable SLCs, surgically removed fresh spleens were treate

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Boquest, A. C., A. Noer, A. L. Sørensen, K. Vekterud, and P. Collas. "220 CpG METHYLATION PROFILE OF ADIPOGENIC AND ENDOTHELIAL GENE PROMOTERS IN HUMAN ADIPOSE STEM CELLS SUGGESTS A RESTRICTIVE ENDOTHELIAL DIFFERENTIATION POTENTIAL." Reproduction, Fertility and Development 19, no. 1 (2007): 227. http://dx.doi.org/10.1071/rdv19n1ab220.

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Mesenchymal stem cells (MSCs) have received intense research interest due to their perceived potential application in regenerative medicine; nevertheless, MSCs are primarily restricted to form mesodermal cell types. Adipose stem cells (ASCs) with a CD34+ CD105+ CD45– CD31– immunophenotype can be obtained in an uncultured state with high purity from the stromal vascular fraction of human liposuction material (Boquest et al. 2005 Mol. Biol. Cell 16, 1131–1141). While ASCs differentiate readily into adipocytes, their endothelial lineage commitment has been scarcely reported, and controversy remai

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7

Buchner, Maike, Natalie Stickel, Arlette Dörffel, et al. "SYK Inhibition Targets CD38−Mediated Survival and Proliferation Signals in Chronic Lymphocytic Leukemia Cells." Blood 118, no. 21 (2011): 800. http://dx.doi.org/10.1182/blood.v118.21.800.800.

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Abstract Abstract 800 Chronic Lymphocytic Leukemia (CLL) is characterized by an accumulation of mature monoclonal B cells in the blood, secondary lymphoid tissue, and marrow. The highly variable prognosis of the disease may be predicted using a number of biomarkers, including the expression level of CD38. Human CD38 is a surface glycoprotein with enzymatic activity and the ability to mediate cell-cell interactions by binding the non-substrate ligand CD31. CD31/CD38 interactions drive CLL proliferation and chemotaxis, and increase CXCL-12-mediated signals and homing of CLL cells towards lymphoi

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8

Zehnder, J. L., K. Hirai, M. Shatsky, J. L. McGregor, L. J. Levitt, and L. L. Leung. "The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes." Journal of Biological Chemistry 267, no. 8 (1992): 5243–49. http://dx.doi.org/10.1016/s0021-9258(18)42758-5.

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9

Slone, Stephen P., Donald R. Fleming, and John J. Buchino. "Sinus Histiocytosis With Massive Lymphadenopathy and Langerhans Cell Histiocytosis Express the Cellular Adhesion Molecule CD31." Archives of Pathology & Laboratory Medicine 127, no. 3 (2003): 341–44. http://dx.doi.org/10.5858/2003-127-0341-shwmla.

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Abstract Context.—We investigated expression of the adhesion molecule CD31 in sinus histiocytosis with massive lymphadenopathy (SHML) and Langerhans cell histiocytosis (LCH) because (1) SHML and LCH cells express a variety of cellular adhesion molecules and (2) SHML has been characterized as a reactive histiocytic proliferation, and tissue macrophages (histiocytes) are known to express CD31. Objective.—The purpose of this study was to determine whether SHML and LCH cells express CD31 and whether dual staining with CD31 and S100 facilitates diagnosis of these disease states. Methods.—Formalin-f

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10

An, Gang, Hua Jiang, Chirag Acharya, et al. "SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma." Blood 124, no. 21 (2014): 4729. http://dx.doi.org/10.1182/blood.v124.21.4729.4729.

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Abstract CD38, a type II transmembrane glycoprotein with both ecto-enzyme activity and receptor function, is highly expressed at the surface of many hematological cancer cells. Recently, SAR 650984 (SAR), a novel humanized anti-CD38 monoclonal antibody in early clinical development, has shown an impressive and durable single agent activity in patients with multiple myeloma (MM). To further characterize the biological function of CD38 in MM cells, we generated RPMI8226 MM cells overexpressing CD38 (R-CD38) by lentiviral infection followed by blascitidin selection. R-CD38, maintained in 10 mg/ml

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Delgado, Pilar, and Balbino Alarcón. "An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor." Journal of Experimental Medicine 201, no. 4 (2005): 555–66. http://dx.doi.org/10.1084/jem.20041133.

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Exit from the endoplasmic reticulum (ER) is an important checkpoint for proper assembly of multimeric plasma membrane receptors. The six subunits of the T cell receptor (TCR; TCRα, TCRβ, CD3γ, CD3δ, CD3ε, and CD3ζ) are each endowed with ER retention/retrieval signals, and regulation of its targeting to the plasma membrane is therefore especially intriguing. We have studied the importance of the distinct ER retention signals at different stages of TCR intracellular assembly. To this end, we have characterized first the presence of ER retention signals in CD3γ. Despite the presence of multiple E

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12

Caligiuri, Giuseppina. "Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology." Cardiovascular Research 115, no. 9 (2019): 1425–34. http://dx.doi.org/10.1093/cvr/cvz132.

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Abstract Biomechanical changes in the heart and vessels drive rapid and dynamic regulation of blood flow, a vital process for meeting the changing metabolic needs of the peripheral tissues at any given point in time. The fluid movement of the blood exerts haemodynamic stress upon the solid elements of the cardiovascular system: the heart, vessels, and cellular components of the blood. Cardiovascular diseases can lead to prolonged mechanical stress, such as cardiac remodelling during heart failure or vascular stiffening in atherosclerosis. This can lead to a significantly reduced or increasingl

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13

Saborit-Villarroya, Ifigenia, Tiziana Vaisitti, Davide Rossi, et al. "E2A Transcriptionally Regulates CD38 Expression In Chronic Lymphocytic Leukemia." Blood 116, no. 21 (2010): 3599. http://dx.doi.org/10.1182/blood.v116.21.3599.3599.

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Abstract Abstract 3599 CD38 is a cell surface molecule endowed with enzymatic and receptor functions. As an enzyme, CD38 is part of a large family of nucleotide-metabolizing ecto-enzymes (NMEs) involved in the catabolism of extra-cellular nucleotides. Its activity results in the dismantling of NAD and the generation of Ca2+ mobilizing compounds. CD38 also bind CD31, a non substrate ligand, expressed by endothelial and stromal cells. In the neoplastic context, CD38/CD31 interactions lead to increased proliferation, survival and chemotaxis. CD38 is a negative prognostic marker for chronic lympho

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14

Chai, DongDong, Lei Zhang, SiWei Xi, YanYong Cheng, Hong Jiang, and Rong Hu. "Nrf2 Activation Induced by Sirt1 Ameliorates Acute Lung Injury After Intestinal Ischemia/Reperfusion Through NOX4-Mediated Gene Regulation." Cellular Physiology and Biochemistry 46, no. 2 (2018): 781–92. http://dx.doi.org/10.1159/000488736.

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Background/Aims: Nuclear erythroid 2-related factor-2 (Nrf2) is a major stress-response transcription factor that has been implicated in regulating ischemic angiogenesis. We investigated the effects of Nrf2 in regulating revascularization and modulating acute lung injury. Methods: The expression of Nrf2 and sirtuin1 (Sirt1) was assessed in lung tissue by western blotting and immunofluorescence staining after intestinal ischemia/reperfusion (IIR) in Nrf2–/– and wild-type (WT) mice. The involvement of Nrf2 in angiogenesis, cell viability, and migration was investigated in human pulmonary microva

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Minchenko, Dmytro O., D. O. Tsymbal, O. P. Yavorovsky, N. V. Solokha, and O. H. Minchenko. "Expression of genes encoding IGFBPs, SNARK, CD36, and PECAM1 in the liver of mice treated with chromium disilicide and titanium nitride nanoparticles." Endocrine Regulations 51, no. 2 (2017): 84–95. http://dx.doi.org/10.1515/enr-2017-0008.

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AbstractObjective. The aim of the present study was to examine the effect of chromium disilicide and titanium nitride nanoparticles on the expression level of genes encoding important regulatory factors (IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, SNARK/NUAK2, CD36, and PECAM1/CD31) in mouse liver for evaluation of possible toxic effects of these nanoparticles.Methods. Male mice received 20 mg chromium disilicide nanoparticles (45 nm) and titanium nitride nanoparticles (20 nm) with food every working day for 2 months. The expression of IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, SNARK, CD36, and PECAM

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16

Tsuneki, Masayuki, and Joseph A. Madri. "CD44 Regulation of Endothelial Cell Proliferation and Apoptosis via Modulation of CD31 and VE-cadherin Expression." Journal of Biological Chemistry 289, no. 9 (2014): 5357–70. http://dx.doi.org/10.1074/jbc.m113.529313.

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17

de Resende, Micheline M., Sandra L. Amaral, Diane H. Munzenmaier, and Andrew S. Greene. "Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake." Physiological Genomics 25, no. 2 (2006): 325–35. http://dx.doi.org/10.1152/physiolgenomics.00253.2005.

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Angiogenesis, under normal conditions, is a tightly regulated balance between pro- and antiangiogenic factors. The goal of this study was to investigate the mechanisms involved in the control of the skeletal muscle angiogenic response induced by electrical stimulation during the suppression of plasma renin activity (PRA) with a high-salt diet. Rats fed 0.4% or 4% salt diets were exposed to electrical stimulation for 7 days. The tibialis anterior (TA) muscles from stimulated and unstimulated hindlimbs were removed and prepared for gene expression analysis, CD31-terminal deoxynucleotide transfer

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18

Wang, Zhikui, Zhongqi Zhou, Wenjie Ji, et al. "Silencing of lncRNA 6030408B16RIK prevents ultrafiltration failure in peritoneal dialysis via microRNA-326-3p-mediated WISP2 down-regulation." Biochemical Journal 477, no. 10 (2020): 1907–21. http://dx.doi.org/10.1042/bcj20190877.

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Continuous exposure to peritoneal dialysis (PD) fluid results in peritoneal fibrosis and ultimately causes ultrafiltration failure. Noncoding RNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been reported to participate in ultrafiltration failure in PD. Therefore, our study aimed to investigate the mechanism of lncRNA 6030408B16RIK in association with miR-326-3p in ultrafiltration failure in PD. Peritoneal tissues were collected from uremic patients with or without PD. A uremic rat model with PD was first established by 5/6 nephrectomy. The relationship between lncRNA

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19

Feng, Yuxin, Ming Liu, Fukun Guo, et al. "Novel Method to Study Mouse Bone Marrow Endothelial Cells in Vivo and in Vitro." Blood 120, no. 21 (2012): 617. http://dx.doi.org/10.1182/blood.v120.21.617.617.

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Abstract Abstract 617 Self-renewal, differentiation, and proliferation of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) are maintained in a complex microenvironment of the adult bone marrow (BM). BM endothelial cells (ECs) have been proposed to be a key component of HSC and LSC niche. However, in contrast to the well-developed culture system of human ECs, current work of murine BM endothelial cells is hindered by a lack of mouse bone marrow endothelial cell primary culture and suitable assay methods to clearly define murine BMEC functionality in vivo and in vitro, which limits

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20

Ma, L., C. Mauro, G. H. Cornish, et al. "Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance." Proceedings of the National Academy of Sciences 107, no. 45 (2010): 19461–66. http://dx.doi.org/10.1073/pnas.1011748107.

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21

Koeck, Ruth, Dominik G. F. Wolf, Holger F. Rumpold, et al. "Human Endothelial Cells Generated In Vitro from Circulating Progenitors Represent a Safe Tool for Targeting of Myocardial Tissue." Blood 104, no. 11 (2004): 4138. http://dx.doi.org/10.1182/blood.v104.11.4138.4138.

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Abstract Various cell sources, culture protocols and characerization steps are being used in the research field of endothelial progenitors and circulating endothelial cells. We generated EPC by plating the mononuclear fraction onto a collagen I-coated well of a six-well-plate in endothelial cell medium. After 6 to 12 days, 1–10 clones with cobblestone morphology appeared and grew rapidly to confluency within a few days. The rapid proliferation of EPC decelerated after 30–40 days, remaining on the same level for additional 30 days and finally stopped after 70–80 days of culture. Immunofluoresce

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Benkisser-Petersen, Marco, Maike Buchner, Arlette Dörffel, et al. "SYK Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia." Blood 126, no. 23 (2015): 2910. http://dx.doi.org/10.1182/blood.v126.23.2910.2910.

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Abstract B-cell chronic lymphocytic leukemia (CLL) is one of the most prevalent B cell malignancies in adults and characterized by expansion of monoclonal mature B cells. Survival and proliferation of CLL cells depends on microenvironmental contact in lymphoid organs. The transmembrane glycoprotein CD38 acts as an important mediator of survival, proliferation and migration signals for CLL cells, and its expression is associated with poor prognosis. Spleen tyrosine kinase (SYK) is a central element of the B-cell receptor signal transduction pathway and has additionally been shown to be involved

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Nishikii, Hidekazu, Koji Eto, Noriko Tamura, et al. "Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells." Journal of Experimental Medicine 205, no. 8 (2008): 1917–27. http://dx.doi.org/10.1084/jem.20071482.

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Embryonic stem cells (ESCs) could potentially compensate for the lack of blood platelets available for use in transfusions. Here, we describe a new method for generating mouse ESC-derived platelets (ESPs) that can contribute to hemostasis in vivo. Flow cytometric sorting of cells from embryoid bodies on day 6 demonstrated that c-Kit+ integrin αIIb (αIIb)+ cells, but not CD31+ cells or vascular endothelial cadherin+ cells, are capable of megakaryopoiesis and the release of platelet-like structures by day 12. αIIbβ3-expressing ESPs exhibited ectodomain shedding of glycoprotein (GP)Ibα, GPV, and

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Kreisel, Friederike, Amanda Blasius, Marco Colonna, and Marina Cella. "Natural Interferon Producing Cells Develop from Murine CD31+(high)/Ly6C- Marrow Progenitors." Blood 104, no. 11 (2004): 4169. http://dx.doi.org/10.1182/blood.v104.11.4169.4169.

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Abstract Dendritic cells (DC) play a critical role in the initiation and regulation of immune responses. Based on immunophenotypic and functional charcateristics, murine CD11c+ DC can be classified into CD11c+, CD11b+, and B220− “conventional” DC and CD11c+, CD11b−/dim, B220+, and Gr-1+ interferon-producing cells (IPC) or plasmacytoid dendritic cells (pDC). The developmental origin of IPC remains controversial. In this study, we investigated the capacity of different murine bone marrow subpopulations to acquire immunophenotypic, morphologic and functional characteristics of IPC after in vitro

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Vaisitti, Tiziana, Valentina Audrito, Sara Serra, et al. "Regulation Of CLL Growth and Trafficking By The Enzymatic Functions Of CD38: Implications For Therapeutic Targeting." Blood 122, no. 21 (2013): 4112. http://dx.doi.org/10.1182/blood.v122.21.4112.4112.

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Abstract CD38 is a cell surface receptor and enzyme. As a receptor CD38 interacts with CD31 activating a well characterized signaling pathway. As an enzyme, it metabolizes NAD generating Ca2+ mobilizing messengers, including cADPR and ADPR. In CLL, CD38 acts as a negative prognostic marker: its expression by the leukemic component is associated with a more aggressive clinical course and a worse overall survival. We and others have shown that CD38 is also a critical element in the pathogenetic network underlying the disease by functioning as a compass which drives CLL cells to growth-favorable

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Attia, Yasmin M., Samia A. Shouman, Salama A. Salama, et al. "Blockade of CDK7 Reverses Endocrine Therapy Resistance in Breast Cancer." International Journal of Molecular Sciences 21, no. 8 (2020): 2974. http://dx.doi.org/10.3390/ijms21082974.

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Cyclin-dependent kinase (CDK)-7 inhibitors are emerging as promising drugs for the treatment of different types of cancer that show chemotherapy resistance. Evaluation of the effects of CDK7 inhibitor, THZ1, alone and combined with tamoxifen is of paramount importance. Thus, in the current work, we assessed the effects of THZ1 and/or tamoxifen in two estrogen receptor-positive (ER+) breast cancer cell lines (MCF7) and its tamoxifen resistant counterpart (LCC2) in vitro and in xenograft mouse models of breast cancer. Furthermore, we evaluated the expression of CDK7 in clinical samples from brea

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Park, Sunyoung, Christine M. Sorenson, and Nader Sheibani. "PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis." Clinical Science 129, no. 3 (2015): 217–34. http://dx.doi.org/10.1042/cs20140714.

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Vascular development and maintenance of proper vascular function through various regulatory mechanisms are critical to our wellbeing. Delineation of the regulatory processes involved in development of the vascular system and its function is one of the most important topics in human physiology and pathophysiology. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a cell adhesion molecule with proangiogenic and proinflammatory activity, has been the subject of numerous studies. In the present review, we look at the important roles that PECAM-1 and its isoforms play during angiogenesi

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Lu, Shuo, Zhifeng Sun, Li Tang, and Lingling Chen. "The Down-Regulation of Treg Expression by CD18–/– to Inhibit Kidney Cancer Pathogenesis." Journal of Biomaterials and Tissue Engineering 9, no. 5 (2019): 714–18. http://dx.doi.org/10.1166/jbt.2019.2038.

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Objective: Gene mutation is closely related to the occurrence of renal cell carcinoma. Regulatory T cells play an important role in cancer. Our study aimed to investigate how CD18 affects tumor cells in renal cell carcinoma. Methods: 30 models of mice with renal cell carcinoma were established by gene engineering mouse with CD18 deficient, another 30 normal C57 mice were used as control. Ki67 and microvessel density were detected by immunohistochemistry (IHC) and immunofluorescence respectively to assess whether the model was established successfully. The expression of CD3, CD4 and CD8 were de

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Shi, Shaoyang, Yong Jin, Haishan Song, and Xiaolong Chen. "MicroRNA-34a attenuates VEGF-mediated retinal angiogenesis via targeting Notch1." Biochemistry and Cell Biology 97, no. 4 (2019): 423–30. http://dx.doi.org/10.1139/bcb-2018-0304.

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Pathological angiogenesis in the retina is one of the main ocular diseases closely associated with vision loss. This work investigated the roles of microRNA-34a (miR-34a) and its potential target Notch1, in retinal angiogenesis. For this we used oxygen-induced retinopathy (OIR) rats and human retinal microvascular endothelial cells (HRMECs) stimulated with vascular endothelial growth factor (VEGF). We performed hematoxylin–eosin staining, Western blot for VEGF, and immunofluorescence staining for CD31 to verify the establishment of our OIR model. We observed down-regulation of miR-34a, and up-

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Kim, Cho-Won, and Kyung-Chul Choi. "Potential Roles of Iridoid Glycosides and Their Underlying Mechanisms against Diverse Cancer Growth and Metastasis: Do They Have an Inhibitory Effect on Cancer Progression?" Nutrients 13, no. 9 (2021): 2974. http://dx.doi.org/10.3390/nu13092974.

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Iridoids are glycosides found in plants, having inherent roles in defending them against infection by viruses and microorganisms, and in the rapid repair of damaged areas. The emerging roles of iridoid glycosides on pharmacological properties have aroused the curiosity of many researchers, and studies undertaken indicate that iridoid glycosides exert inhibitory effects in numerous cancers. This review focuses on the roles and the potential mechanism of iridoid glycosides at each stage of cancer development such as proliferation, epithelial mesenchymal transition (EMT), migration, invasion and

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Lia, Giuseppe, Lucia Brunello, Paola Omedè, et al. "Extracellular Vesicles as Potential Biomarker for Acute Graft-Versus-Host-Disease." Blood 128, no. 22 (2016): 2239. http://dx.doi.org/10.1182/blood.v128.22.2239.2239.

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Abstract INTRODUCTION: Graft-versus-Host-Disease (GVHD) is the main cause of non-relapse mortality after Hematopoietic Stem Cells Transplantation (HSCT). Identyfing potential biomarkers of GVHD could be crucial to define patients at high risk of GVHD development and to better assess GVHD grading. One potential attractive biomarker may be represented by extracellular vesicles (EVs). EVs are membrane-enclosed structures secreted by many cell types and may be represented by exosomes, shedding vesicles (microvesicles; MVs) and apoptotic bodies. EVs are detectable in body fluids, in particular peri

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Colletti, Evan, Deena ElShabrawy, Esmail D. Zanjani, Christopher D. Porada, and Graca Almeida-Porada. "Characterization of the Human Hematopoietic Niche During Ontogeny." Blood 114, no. 22 (2009): 3626. http://dx.doi.org/10.1182/blood.v114.22.3626.3626.

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Abstract Abstract 3626 Poster Board III-562 Studies thus far have shown that there are at least two anatomically and physiologically distinct hematopoietic niches within the bone marrow (BM); the osteoblastic and the vascular. The former is thought to provide the appropriate support for quiescent hematopoietic stem cells (HSC), while the latter allows/induces expansion of the HSC pool. However, it is not entirely known which subpopulations of HSC interact with each niche, and what physiological role each niche type plays in the regulation of stem cell hierarchy and function. We hypothesized th

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Sadovnik, Irina, Harald Herrmann, Katharina Blatt, et al. "Evaluation of Cell Surface Markers and Targets in Leukemic Stem Cells (LSC) Reveals Distinct Expression Profiles, Unique Drug Effects, and Specific Checkpoint Regulation in AML LSC and CML LSC." Blood 128, no. 22 (2016): 4234. http://dx.doi.org/10.1182/blood.v128.22.4234.4234.

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Abstract In an attempt to identify novel cell surface markers and targets in leukemic stem cells (LSC) in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), we screened bone marrow (BM) samples of patients with AML (n=257), CML (n=134), and controls (n=256: other BM neoplasms, n=116; normal/reactive BM, n=29; idiopathic cytopenia, n=31; lymphoma patients without BM involvement, n=80) for expression of cell surface markers and targets on CD34+/CD38− stem cells and CD34+/CD38+ progenitor cells (PC) by multi-color flow cytometry. In addition, we examined mRNA expression profiles in

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Katamura,, Kenji, Tetsuya Fukui,, Takahiro Kiyomasu,, Kayo Ohmura,, Jun Iio, and Hideki Ueno. "Regulation of CD31 expression and interleukin-4 production by human cord blood CD4+ T cells with interleukin-4 and interleukin-7." Pediatrics International 42, no. 2 (2000): 126–33. http://dx.doi.org/10.1046/j.1442-200x.2000.01194.x.

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Dercksen, MW, WR Gerritsen, S. Rodenhuis, et al. "Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation." Blood 85, no. 11 (1995): 3313–19. http://dx.doi.org/10.1182/blood.v85.11.3313.bloodjournal85113313.

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Adhesion molecules play a role in the migration of hematopoietic progenitor cells and regulation of hematopoiesis. To study whether the mobilization process is associated with changes in expression of adhesion molecules, the expression of CD31, CD44, L-selectin, sialyl Lewisx, beta 1 integrins very late antigen 4 (VLA-4) and VLA-5, and beta 2 integrins lymphocyte function-associated 1 and Mac-1 was measured on either bone marrow (BM) CD34+ cells or on peripheral blood CD34+ cells mobilized with a combination of granulocyte colony-stimulating factor (G-CSF) and chemotherapy. beta 1 integrin VLA

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Quintela-Fandino, Miguel, Paloma Navarro, Tamara Mondejar, et al. "Differential luminal breast cancer (LBC) reprogramming in response to BIBF1120 (BIBF) or bevacizumab (B)." Journal of Clinical Oncology 31, no. 15_suppl (2013): 11033. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.11033.

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11033 Background: FVB MMTV PyMT is a great mouse model for studying LBC due to its stochastic nature, immune system preservation, natural growth kinetics and ER/HER2 status. We approached the transcriptomic (T), proteomic (P), phospho-proteomic (P-P) and metabonomic (M) layers of regulation of the tumor phenotype attempting to unravel mechanisms of resistance to antiangiogenic drugs (ADs) and find new targets. Methods: Treatments started when tumors measured 0,1cm3; with the VEGFR/PDGFR inhibitor BIBF 85mg/kg/day; a murine analog of B 10mg/kg/biweekly; or vehicle (V). Tumors were harvested at

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Zou, Kejian, Yan Hu, Musheng Li, et al. "Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker." Canadian Journal of Gastroenterology and Hepatology 2019 (July 1, 2019): 1–8. http://dx.doi.org/10.1155/2019/8348967.

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Objective. HMGCS2 is the rate-limiting enzyme of ketogenesis, which is vital for tumor initiation or metastasis. The aim of this study is to determine the relationship between HMGCS2 and tumor angiogenesis.Materials and Methods. The study consisted of 100 cases with colorectal cancer and healthy control, the expression of HMGCS2 and the microvessel density (MVD) (marker: CD31) were analyzed by immunohistochemistry and tube formation, and the centration ofβ-hydroxybutyrate in serum was assessed by biochemical analysis.Results. The results showed that HMGCS2 expression is significantly reduced i

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Ulezko Antonova, Alina, Yitong Wang, Mojibade Hassan, Yiwen Li, and Edmund K. Waller. "CD31 Expression Defines Heterogeneity of Donor Plasmacytoid Dendritic Cell Populations That Home to the Thymus: Implications for Control of GvHD." Blood 132, Supplement 1 (2018): 3325. http://dx.doi.org/10.1182/blood-2018-99-113047.

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Abstract Introduction: Plasmacytoid dendritic cells (pDC) are known to possess tolerogenic properties in allogeneic bone marrow transplantation (allo-BMT), but the relationship between pDC lineage and their modulation of graft-versus-host disease (GvHD) has not been defined. Recently, we have shown that murine treatment with the pleiotropic cytokine FMS-like Tyrosine Kinase 3 Ligand (Flt3L) increases pDC content in the marrow, and that allo-BMT of Flt3L-treated marrow (FBM) grafts leads to higher overall survival and reduced GvHD in lethally irradiated hosts. Furthermore, FBM pDC have increase

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Neri, Paola, Li Ren, Kathy Gratton та ін. "Integrin β7-Mediated Regulation of Multiple Myeloma Cell Adhesion, Migration and Survival." Blood 114, № 22 (2009): 949. http://dx.doi.org/10.1182/blood.v114.22.949.949.

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Abstract Abstract 949 Background: Integrin β7 (ITGB7) mRNA is detected in primary myeloma (MM) cells and its presence was correlated with maf gene activation. However, little is known about the role ITGB7 plays in MM. Methods and results: We have determined the expression of ITGB7 by flow cytometry in a large library of human MM cell lines and found it to be universily expressed, albeit at different levels. Similarly ITGB7 mRNA was detected by qRT-PCR in 25/27 samples of primary MM CD138+ cells. In order to better investigate the role of ITGB7 in MM adhesion, migration and survival we performe

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Vodyanik, Maxim, Priya Togarrati, Kran Suknuntha, Kyung-Dal Choi, and Igor Slukvin. "Identification of Distinct Pathways Involved in Regulation of Mesenchymoangioblasts and Hemangioblasts Development From Mesoderm." Blood 118, no. 21 (2011): 1326. http://dx.doi.org/10.1182/blood.v118.21.1326.1326.

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Abstract Abstract 1326 Using hESC differentiation system we recently identified a mesenchymoangioblast (MAB) as a novel precursor for mesenchymal stem cells (MSCs) and endothelial cells and demonstrated that mesenchymal and hematopoietic cells develop sequentially from mesodermal precursors with primary angiogenic potential – MAB and hemangioblasts (HB), respectively. In addition, we found that angiogenic mesoderm reminiscent of lateral plate/extraembryonic mesoderm in the embryo can be identified by surface expression of apelin receptor (APLNR) and lack of expression of typical endothelial (C

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Jaimes, Yarúa, Ananta Paine, Constanca Figueiredo, et al. "PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells." Thrombosis and Haemostasis 111, no. 06 (2014): 1077–88. http://dx.doi.org/10.1160/th13-11-0923.

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SummaryThe antioxidant enzyme heme oxygenase (HO)-1, which catalyses the first and rate-limiting step of heme degradation, has major anti-inflammatory and immunomodulatory effects via its cell-type-specific functions in the endothelium. In the current study, we investigated whether the key endothelial adhesion and signalling receptor PECAM-1 (CD31) might be involved in the regulation of HO-1 gene expression in human endothelial cells (ECs). To this end PECAM-1 expression was down-regulated in human umbilical vein ECs (HUVECs) by an adenoviral vector-based knockdown approach. PECAM-1 knockdown

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Lai, Baochang, Zhao Li, Ming He, et al. "Atheroprone flow enhances the endothelial-to-mesenchymal transition." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 5 (2018): H1293—H1303. http://dx.doi.org/10.1152/ajpheart.00213.2018.

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The endothelial-to-mesenchymal transition (EndoMT) is a cellular process featuring decreased expression of endothelial marker genes but increased expression of mesenchymal marker genes. The EndoMT is involved in endothelial dysfunction and the pathogenesis of atherosclerosis. To investigate the dynamic expression of EndoMT genes in vascular endothelial cells under atheroprotective pulsatile shear stress (PS) and atheroprone oscillatory shear stress (OS), we analyzed RNA sequencing data from multitimepoint shear-stress experiments. This unbiased analysis involving next-generation sequencing con

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Singh, Pratibha, and Louis M. Pelus. "Neuropeptide Y Is Critical for Bone Marrow Stromal Cells and Hematopoietic Recovery Following Injury." Blood 128, no. 22 (2016): 173. http://dx.doi.org/10.1182/blood.v128.22.173.173.

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Abstract Bone marrow suppression is the most common limiting side-effect of conventional cancer chemo/radio therapy and is the primary cause of morbidity/mortality after accidental exposure to a high dose of ionizing radiation. The mechanisms mediating radiation-induced hematopoietic stem and stromal cell dysfunction however are not well understood. Radiation therapy causes substantial sensory neuropathy in patients. Recent studies reveal that bone marrow cells are highly innervated by sympathetic nerve fibers and that chemotherapy induced nerve-damage can impair hematopoietic regeneration, su

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Li, Xin, Jiahua Zhang, Jun Liu, and Shiang Huang. "Comparison of Differential microRNA Expression Profiles between CD34+CD38− and CD34+CD38+ Cells in Both Umbilical Cord Blood and Acute Myeloid Leukemia." Blood 108, no. 11 (2006): 4272. http://dx.doi.org/10.1182/blood.v108.11.4272.4272.

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Abstract Recent studies demonstrated that some miRNAs played an important role in human normal and malignant hematopoiesis. MicroRNA expression is tissue and developmental stage restricted. Therefore, in order to address the roles of miRNAs in the regulation and maintenance of normal hematopoietiesis and leukemogenesis, in this study, we performed an analysis of differential genome-wide miRNA expressions of CD34+CD38− and CD34+CD38+ cells from human umbilical cord blood(CB) and acute myeloid leukemia(AML) bone marrow, respectively. Methods Mononuclear cells from cord blood (CB) and AML bone ma

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Burnatowska-Hledin, Maria, Inara B. Lazdins, Laura Listenberger, et al. "VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule." American Journal of Physiology-Renal Physiology 276, no. 2 (1999): F199—F209. http://dx.doi.org/10.1152/ajprenal.1999.276.2.f199.

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The vasopressin-activated calcium-mobilizing (VACM-1) protein is a novel arginine vasopressin (AVP) receptor that shares sequence homology with a cullin multigene family but not with the AVP receptors. To characterize the VACM-1 receptor, we examined its tissue-specific expression using Northern blot, RT-PCR, and immunostaining analyses. Northern blot hybridization identified a 6.4-kb cRNA species that was expressed in the rabbit kidney medulla, brain, heart, and ovaries. In human tissue, VACM-1 mRNA is a larger (7.5 kb) cRNA found in the kidney, brain, heart, placenta, and skeletal muscle. VA

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Yang, Xiaoping, Jingjing Gu, Tingting Yang, Rui Zhou, and Bo Zheng. "Biological Characteristics of Human Skeletal Muscle-Derived Pericytes/Perivascular Cells and Their Supporting Effects on Hematopoietic Stem Cell in Vitro." Blood 134, Supplement_1 (2019): 5006. http://dx.doi.org/10.1182/blood-2019-130416.

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Mesenchymal stem/stromal cells (MSCs) as precursor cells of bone marrow stromal cells, in addition to the formation of the bone marrow microenvironment, secrete a variety of blood-related factors, promote hematopoietic recovery and reconstruction. However, mesenchymal stem/stromal cells are extremely rare within human bone marrow, which limit their experimental and clinical applications. Our previous study demonstrated that MSCs were derived from pericytes/perivascular cells (PCs), and PCs were the precursor of MSCs. PCs are widely distributed, especially in skeletal muscle tissue, which are r

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Singh, Pratibha, Jennifer Speth, Peirong Hu, and Louis M. Pelus. "CXCR4-SDF-1 Signaling Mediated up-Regulation of Survivin Expression In Mesenchymal Progenitor Cells Is Critical for Their Proliferation and Maintenance of Osteoblastic Niche." Blood 116, no. 21 (2010): 941. http://dx.doi.org/10.1182/blood.v116.21.941.941.

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Abstract Abstract 941 Hematopoietic stem cells reside in osteoblastic and vascular niches within the bone marrow. The osteoblastic niche is composed of mesenchymal stem cell derived progenitor cells (MPC) and osteoblasts and are the main sources of the CXC chemokine CXCL12/SDF-1 in the bone marrow microenvironment. Several published studies suggest that the interaction between CXCR4 expressed on hematopoietic stem cells with SDF-1 produced in the bone marrow microenvironment is important for their retention in the bone-marrow. However, the role of SDF-CXCR4 signaling in formation and maintenan

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Gong, Yuping, Ruiqing Zhoui, and Ting Niu. "The Role of Transcription Factor SCL/TAL-1 in the Hematopoiesis of Human Cord Blood Hematopoietic Stem Cell." Blood 118, no. 21 (2011): 4795. http://dx.doi.org/10.1182/blood.v118.21.4795.4795.

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Abstract Abstract 4795 The role of transcription factor SCL/TAL-1 in the hematopoiesis was studied in the CD34+ hematopoietic stem cells purified from human cord blood. The sorted CD34+ cells were transfected by the plasmids pTRIPdU3-RNAiTALh-EF1a-GFP (SCL/TAL1 shRNA to reduce the expression of SCL/TAL-1), pTRIP-EF1a-TAL1 (SCL/TAL-1 cDNA to enhance the expression of SCL/TAL-1) and control plasmid pTRIP-dU3-RNAiluc-EF1-GFP expressing EGFP gene via lentiviral vector system, named the groups of SCL/TAL-1low, SCL/ TAL-1high and LUC control, and then cultured in methylcellulose medium. The clone fo

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Riedl, Elisabeth, Johannes Stöckl, Otto Majdic, Clemens Scheinecker, Walter Knapp, and Herbert Strobl. "Ligation of E-cadherin on in vitro–generated immature Langerhans-type dendritic cells inhibits their maturation." Blood 96, no. 13 (2000): 4276–84. http://dx.doi.org/10.1182/blood.v96.13.4276.

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Abstract Epithelial tissues of various organs contain immature Langerhans cell (LC)-type dendritic cells, which play key roles in immunity. LCs reside for long time periods at an immature stage in epithelia before migrating to T-cell–rich areas of regional lymph nodes to become mature interdigitating dendritic cells (DCs). LCs express the epithelial adhesion molecule E-cadherin and undergo homophilic E-cadherin adhesion with surrounding epithelial cells. Using a defined serum-free differentiation model of human CD34+hematopoietic progenitor cells, it was demonstrated that LCs generated in vitr

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Riedl, Elisabeth, Johannes Stöckl, Otto Majdic, Clemens Scheinecker, Walter Knapp, and Herbert Strobl. "Ligation of E-cadherin on in vitro–generated immature Langerhans-type dendritic cells inhibits their maturation." Blood 96, no. 13 (2000): 4276–84. http://dx.doi.org/10.1182/blood.v96.13.4276.h8004276_4276_4284.

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Epithelial tissues of various organs contain immature Langerhans cell (LC)-type dendritic cells, which play key roles in immunity. LCs reside for long time periods at an immature stage in epithelia before migrating to T-cell–rich areas of regional lymph nodes to become mature interdigitating dendritic cells (DCs). LCs express the epithelial adhesion molecule E-cadherin and undergo homophilic E-cadherin adhesion with surrounding epithelial cells. Using a defined serum-free differentiation model of human CD34+hematopoietic progenitor cells, it was demonstrated that LCs generated in vitro in the

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