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Dissertations / Theses on the topic 'CD44 antigen'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Varelias, Antiopi. "Studies of CD44 variant isoform expression and function on activated human peripheral blood mononuclear cells and in renal transplantation." Title page, summary and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phv293.pdf.

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2

Voort, Robbert van der. "Hepatocyte growth factor, Met, and CD44 a ménage à trois in B cells /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/55874.

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3

Föger, Niko. "Costimulatory function of CD44 : acting in unison with the T cell receptor." kostenfrei, 2000. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-1186.

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4

Lein, Michael Torsten. "Neue Serummarker bei urologischen Malignomen mit dem Schwerpunkt Prostatakarzinom und Anwendung von Proteinase-Inhibitoren in der Therapie des Prostatakarzinoms." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13730.

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Die vorliegende Habilitationsschrift "Neue Serummarker bei urologischen Malignomen mit dem Schwerpunkt Prostatakarzinom und Anwendung von Proteinase-Inhibitoren in der Therapie des Prostatakarzinoms" faßt Ergebnisse zusammen, die ich in den Jahren von 1996 bis 2000 als Erstautor in wissenschaftlichen Artikeln von peer reviewed Zeitschriften veröffentlicht habe. Zusätzlich werden 14 Arbeiten mit ihren Aussagen eingeschlossen, bei denen ich als Koautor beteiligt war. Gegenstand der Habilitationsschrift sind Untersuchungen zur diagnostischen Optimierung des Tumormarkers Prostataspezifisches Ant

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5

Bernardi, Maria Auxiliadora. "Expressão de CD44 e CD24 em carcinomas mamários ductais invasivos de acordo com análise dos subtipos moleculares e sua relação com fatores prognósticos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-27102011-172419/.

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Carcinomas de mama são heterogêneos e consistem de diversos tipos celulares. Perfis de expressão gênica usando DNA microarrays identificaram quatro subtipos moleculares fundamentais baseados na expressão de receptores hormonais (estrógeno e progesterona) e de fator de crescimento epidérmico (HER2) (luminal tipo A, luminal tipo B, tumores expressando somente HER2 e triplos negativos) refletindo a heterogeneidade molecular dos carcinomas. Sugeriu-se que esta heterogeneidade advém da presença de células tronco tumorais com a capacidade de se diferenciar ao longo de vias divergentes e outros estud

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6

Haas, Karen Marie. "Induction and regulation of bovine B lymphocyte responses /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999290.

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7

Giordanengo, Valérie. "Glycoproteines lymphocytaires, infection vih et autoimmunite." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX20652.

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8

Schmitz, Paul. "Mechanismen immunologischer Toleranz nach Lebertransplantation : Untersuchungen zum Zytokinmuster intrahepatischer CD4+ CD45RCpos und CD4+ CD45RCneg T-Lymphozyten." Doctoral thesis, kostenfrei, 2007. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-26703.

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9

Saeland, Sem. "Caractérisation et physiologie in vitro des cellules hématopoïétiques humaines exprimant l'antigène CD34." Lyon 1, 1992. http://www.theses.fr/1992LYO1H053.

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10

Rose, Charlotte S. P. "CD4 antigen chimaeras of poliovirus." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240217.

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11

Haas, Karen M. "Induction and regulation of bovine B lymphocyte responses." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999290.

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12

郑健 and Jian Zheng. "Generation of human allo-antigen specific CD4+ and CD8+ regulatory T cells with CD40-activated B cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46922969.

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13

Mischke, Dirk. "Generierung regulatorischer T-Zellen aus naiven CD4+-CD45RA+-T-Zellen durch Anti-CD4-Interaktion." Berlin wvb, Wiss. Verl, 2007. http://www.wvberlin.de/data/inhalt/mischke_dirk.html.

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14

Li, Ming 1957. "Generation of CD8+ T cell immunity with help from CD4+ T cells." Monash University, Dept. of Pathology and Immunology, 2002. http://arrow.monash.edu.au/hdl/1959.1/8476.

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15

Barton, Gregory Methven. "Positive selection of CD4 T cells by specific peptide-MHC class II complexes /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/4994.

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16

Schubert, Lisa Ann. "Characterization of the transcriptional regulation of the human CD40L gene in CD4 T cells /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8325.

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17

Garcia, Alexandre Simões. "Valor prognóstico da imunoexpressão de podoplanina e de CD44v6 na recidiva locorregional dos pacientes com câncer de lábio." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-05092017-203930/.

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O objetivo deste estudo consistiu em avaliar a expressão imuno-histoquímica da podoplanina e do CD44v6 pelas células malignas, verificando a associação destas proteínas com as variáveis clínicas, microscópicas, com o índice histopatológico de malignidade e com a sobrevivência livre de doença de 91 pacientes portadores de carcinomas espinocelulares (CEC) de lábio inferior, tratados no Centro de Tratamento e Pesquisa do Hospital do Câncer A.C.Camargo, São Paulo. Os tumores foram corados, separadamente, com os anticorpos anti-podoplanina e anti-CD44v6, sendo avaliada a imunoexpressão destas prote

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18

Wheeler, Paul Richard. "Characterisation of T cell anergy in allo-antigen specific CD4âº cells." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288516.

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19

Rossmanith, Tanja. "Kultivierung von CD34+-Zellen aus Nabelschnurblut zur Ex-vivo-Expansion von Stamm- und Vorläuferzellen und Untersuchungen zu deren Homing-Fähigkeiten." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96362525X.

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20

Müller, Marguerite. "Bestimmung der Verweildauern von 111In-markierten anti-CD66 und anti-CD45 Antikörpern im Rahmen der Konditionierung vor Blutstammzelltransplantation." [S.l. : s.n.], 2009. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-66243.

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21

Stone, John David. "T-cell antigen receptor signal transduction in CD45-null thymocytes." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627126.

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22

Kennedy, Colleen. "A study of size and compositional heterogeneity of membrane rafts of CD4+ T cells." Click here for download, 2008. http://proquest.umi.com/pqdweb?did=1568973711&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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23

Goupille, Caroline. "Commutation fucose/acide sialique au niveau d'un variant du CD44 : conséquences sur le comportement de cellules de carcinome colique." Nantes, 1997. http://www.theses.fr/1997NANT04VS.

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24

Bridoux, Lucie Charpentier Emmanuelle. "Effet de l'inhibiteur tissulaire des métalloprotéinases-1 (TIMP-1) dans les cellules érythroïdes normales et cancéreuses humaines. Caractérisation du récepteur." Reims : S.C.D. de l'Université, 2009. http://scdurca.univ-reims.fr/exl-doc/GED00001015.pdf.

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25

Yin, Liusong. "Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/700.

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Antigen presented to CD4+ T cells by major histocompatibility complex class II molecules (MHCII) plays a key role in adaptive immunity. Antigen presentation is initiated by the proteolytic cleavage of pathogenic or self proteins and loading of resultant peptides to MHCII. The loading and exchange of peptides to MHCII is catalyzed by a nonclassical MHCII molecule, HLA-DM (DM). It is well established that DM promotes peptide exchange in vitro and in vivo. However, the mechanism of DM-catalyzed peptide association and dissociation, and how this would affect epitope selection in human responses to

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26

Rogers, Paul R. "Analysis of CD45 Alternative Exon Expression in Murine and Human CD4⁺ T Cell Subpopulations: a Thesis." eScholarship@UMMS, 1993. http://escholarship.umassmed.edu/gsbs_diss/282.

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Leukocytes express a family of high molecular weight glycoproteins called leukocyte common antigens (CD45) which have tyrosine phosphatase activity and are involved in phosphotyrosine signal transduction. Antibodies to different CD45 isoforms distinguish functionally different CD4+ T cell subsets in humans, rats, and mice. Selected protein isoforms are expressed through a process of exon splicing which is cell-type and differentiation-state specific. Splicing of the three variable exons, A, B, and C, which encode amino acids located near the extracellular amino terminus of the protein, potenti

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27

Behrendt, Anne. "Differential antigen dependency of CD4+ and CD8+ T cells." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171521.

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28

Jellison, Evan Robert. "CD4 T Cell-Mediated Lysis and Polyclonal Activation of B Cells During Lymphocytic Choriomeningitis Virus Infection: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/349.

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CD4 T cells and B cells are cells associated with the adaptive immune system. The adaptive immune system is designed to mount a rapid antigen-specific response to pathogens by way of clonal expansions of T and B cells bearing discrete antigen-specific receptors. During viral infection, interactions between CD4 T cells and B cells occur in a dynamic process, where B cells that bind to the virus internalize and degrade virus particles. The B cells then present viral antigens to virus-specific CD4 T cells that activate the B cells and cause them to proliferate and differentiate into virus-specifi

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29

Védrine, Mégane. "Rôle de l'antigène O dans la reconnaissance d'Escherichia coli par les cellules épithéliales mammaires bovines et modulation par le CD14 soluble." Thesis, Tours, 2019. http://www.theses.fr/2019TOUR4002.

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Les mammites constituent la première source de pertes financières des cheptels bovins laitiers en France et dans le monde. Parmi les agents pathogènes des infections mammaires, Escherichia coli (E. coli) représente la bactérie majeure impliquée dans les cas de mammites cliniques aigues. La part des facteurs de l’hôte dans la capacité à éliminer le pathogène causal est en partie avérée, tandis que le lien entre caractéristiques bactériennes et sévérité de l’infection est plus délicat à établir. Cette étude s’attache donc à déterminer les facteurs bactériens importants dans les interactions entr

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30

Zilch, Christian Frank. "The control of alternative splicing of the leucocyte common antigen (CD45)." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287198.

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31

Matthes, Constanze. "Immunmodulation Dendritischer Zellen durch Sekretionsprodukte mesenchymaler Stammzellen mit besonderem Focus auf hCyr61/CCN1." Doctoral thesis, kostenfrei, 2008. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-28129.

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32

Khuseyinova, Natalie. "Association between plasma levels of the soluble CD14 receptor of lipopolysaccharide and the C(-260)T polymorphism in the promoter of the CD14 gene and coronary artery disease: investigations in a large case-control study." Ulm : Universität Ulm, Medizinische Fakultät, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9967025.

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33

Pelletier, Ludivine. "Un nouveau rôle pour CD44 dans la transformation cellulaire." Lyon 1, 2006. http://www.theses.fr/2006LYO10103.

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La protéine d’adhérence CD44 est exprimée de façon aberrante dans plusieurs types de cancers mais les mécanismes moléculaires par lesquels elle participe à la tumorigénèse restent mal définis. Le modèle couramment retenu lui attribue un rôle dans la capacité métastatique, un évènement tardif de la tumorigénèse. L’utilisation d’un système original qui mime une activation inductible et réversible de l’oncogène RET dans des fibroblastes de rat, nous a permis de montrer que CD44 participe également aux étapes plus précoces du développement tumoral. L’augmentation d’expression de CD44 au cours de l

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34

Bridoux, Lucie. "Effet de l’inhibiteur tissulaire des métalloprotéinases-1 (TIMP-1) dans les cellules érythroïdes normales et cancéreuses humaines. Caractérisation du récepteur." Reims, 2009. http://theses.univ-reims.fr/exl-doc/GED00001015.pdf.

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En dehors de son activité inhibitrice de MMPs, le TIMP-1 présente d'autres activités biologiques telles que des effets mitogéniques et anti-apoptotiques sur différentes lignées cellulaires. Nous avons montré que le TIMP-1 induit la survie des cellules érythroleucémiques humaines UT-7 en activant la voie JAK2/PI 3-kinase/Akt. Récemment, nous avons montré que le TIMP-1 se fixe à une pro-MMP-9 localisée à la membrane plasmique des cellules UT-7 et que l'expression membranaire de la pro-MMP-9 est nécessaire à l'effet anti-apoptotique du TIMP-1. Dans une première partie, nous montrons que CD44 perm

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35

Grégoire, Claude. "Caractérisation de récepteurs T solubles obtenus par génie génétique." Aix-Marseille 2, 1991. http://www.theses.fr/1991AIX22018.

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Grace aux techniques de genie genetique et de transfert genique, nous avons pu solubiliser le recepteur a l'antigene d'une cellule t cytotoxique. La strategie utilisee consiste a produire des molecules chimeres entre ce recepteur a l'antigene et les immunoglobulines. Ce recepteur t soluble peut egalement servir a generer des anticorps monoclonaux

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36

Müller, Nicole. "Entwicklung antigenabhängig aktivierbarer TNF-Ligand-Fusionsproteine." kostenfrei, 2009. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3648/.

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37

Dong, Qing. "Mechanisms of CD4+ T cell apoptosis and the role of ethanol as a cofactor in HIV pathogenesis." Lexington, Ky. : [University of Kentucky Libraries], 2000. http://lib.uky.edu/ETD/ukynusi2000d00003/ThesisQD.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2000.<br>Title from document title page. Document formatted into pages; contains vi, 137 p. : ill. Includes abstract. Includes bibliographical references (p. 108-135).

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38

Hellström, Martin. "Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1128.

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39

Cameron, Thomas O. (Thomas Owen) 1972. "Characterizing antigen-specific CD4⁺ T cells using HLA-DR oligomers." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/16808.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2002.<br>Vita.<br>Includes bibliographical references (leaves 152-165).<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>T cells are activated by the engagement of their surface T cell receptors (TCR) by antigenic peptide bound to major histocompatibility complex (MHC). The success or failure of this TCR to MHC-peptide interaction determines the specificity of T cell action, and thus plays a central role in proper imm

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40

Zhou, Gang. "Mechanisms of CD4+ T cell anergy induced by tumor antigen." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080806.

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41

Bernhard, Oliver. "Proteomic investigation of the HIV receptors CD4 and DC-SIGN/CD209 membrane protein interactions." Saarbrücken VDM Verlag Dr. Müller, 2004. http://d-nb.info/989278026/04.

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42

Vong, Allen M. "Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/933.

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CD4 T cells differentiate into multiple effector subsets that mediate pathogen clearance. ThCTL are anti-viral effectors with MHC-II restricted cytotoxicity. The factors regulating ThCTL generation are unclear, in part due to a lack of a signature marker. I show here that in mice, NKG2C/E identifies ThCTL that develop in the lung during influenza A virus (IAV) infection. ThCTL phenotype indicates they are highly activated effectors with high levels of binding to P-selectin, T-bet, IFNγ production, and degranulation. ThCTL express increased levels of granzymes and perforin and lower levels of g

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43

Vong, Allen M. "Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/933.

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CD4 T cells differentiate into multiple effector subsets that mediate pathogen clearance. ThCTL are anti-viral effectors with MHC-II restricted cytotoxicity. The factors regulating ThCTL generation are unclear, in part due to a lack of a signature marker. I show here that in mice, NKG2C/E identifies ThCTL that develop in the lung during influenza A virus (IAV) infection. ThCTL phenotype indicates they are highly activated effectors with high levels of binding to P-selectin, T-bet, IFNγ production, and degranulation. ThCTL express increased levels of granzymes and perforin and lower levels of g

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44

Shim, Ho-Ki. "Mechanisms of antigen processing and presentation of CD4 T cell epitopes from the V antigen of Yersinia pestis." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405355.

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45

Jones, Sian Helen. "Analysis of the mouse CD4 T cell repertoire by high efficiency cloning." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287160.

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46

Stillger, Simone. "Aberrante CD45-Expression bei chronischer lymphatischer Leukämie ein möglicher Ansatzpunkt für eine neue Therapie?" Göttingen Sierke, 2007. http://d-nb.info/987489542/04.

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47

Prill, Thomas. "Transiente genetische Markierung CD34-positiver hämatopoetischer Stammzellen für die in vivo Applikation - Implikationen für eine therapeutische Myokardregeneration." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56186.

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48

Karhukorpi, J. (Jari). "The search for links between immunogenetic factors and recurrent miscarriage." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277449.

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Abstract Successful pregnancy is characterized by a shift toward Th2 type immune response and suppression of adaptive immune responses to ensure acceptance of the semi-allogenic fetal graft. Also the innate immune system plays a major role during pregnancy. Recurrent miscarriage is defined as three or more consecutive pregnancy losses. About 1% of all women will suffer recurrent miscarriage. The causes of recurrent miscarriage remain unexplained in half (50%) of the cases. Susceptibility to recurrent miscarriage is probably mediated by Th1 type immune response with pronounced expression and s

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49

Han, Sushan. "Antigen-specific CD4+T cells in Anaplasma marginale infection of calves." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Dissertations/Spring2010/S_Han_121509.pdf.

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50

Bonnard, Madeleine. "A novel role for CD4 in antigen-mediated T-cell activation /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68156.

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A number of T-cell membrane molecules influence the outcome of antigen recognition by TCR/CD3 complex. CD4, by virtue of its non-covalent association with the protein tyrosine kinase lck has the capacity to enhance TCR$ alpha beta$ signalling. The extracellular domain of CD4 interacts with monomorphic determinants of Major Histocompatibility complex class-II molecules such that antigen presented in association with MHC class-II to CD4$ sp+$ T-cells results in the coaggregation of CD4 and TCR/CD3, thus juxtaposing lck and the antigen-receptor complex. Anti-CD4 antibodies abrogate both antigen a

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