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Journal articles on the topic 'CD44 B-Lymphocytes Lymphocyte Activation'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Rivière, Elodie, Juliette Pascaud, Nicolas Tchitchek, et al. "Salivary gland epithelial cells from patients with Sjögren’s syndrome induce B-lymphocyte survival and activation." Annals of the Rheumatic Diseases 79, no. 11 (2020): 1468–77. http://dx.doi.org/10.1136/annrheumdis-2019-216588.

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ObjectivePrimary Sjögren's syndrome (pSS) is characterised by chronic hyperactivation of B lymphocytes. Salivary gland epithelial cells (SGECs) could play a role in promoting B-lymphocyte activation within the target tissue. We aimed to study the interactions between SGECs from patients with pSS or controls and B lymphocytes.MethodsPatients had pSS according to 2016 European League Against Rheumatism/American College of Rheumatology criteria. Gene expression analysis of SGECs and B lymphocytes from pSS and controls isolated from salivary gland biopsies and blood was performed by RNA-seq. SGECs

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2

Ilangumaran, Subburaj, Anne Briol, and Daniel C. Hoessli. "CD44 Selectively Associates With Active Src Family Protein Tyrosine Kinases Lck and Fyn in Glycosphingolipid-Rich Plasma Membrane Domains of Human Peripheral Blood Lymphocytes." Blood 91, no. 10 (1998): 3901–8. http://dx.doi.org/10.1182/blood.v91.10.3901.

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Abstract CD44 is the major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan and is implicated in a variety of biological events that include embryonic morphogenesis, lymphocyte recirculation, inflammation, and tumor metastasis. CD44 delivers activation signals to T lymphocytes, B lymphocytes, natural killer cells, polymorphonuclear leukocytes, and macrophages by stimulating protein tyrosine phosphorylation and calcium influx. The mechanism of signal transduction via CD44 remains undefined, although CD44 was shown to physically associate with intracellular protein

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3

Ilangumaran, Subburaj, Anne Briol, and Daniel C. Hoessli. "CD44 Selectively Associates With Active Src Family Protein Tyrosine Kinases Lck and Fyn in Glycosphingolipid-Rich Plasma Membrane Domains of Human Peripheral Blood Lymphocytes." Blood 91, no. 10 (1998): 3901–8. http://dx.doi.org/10.1182/blood.v91.10.3901.3901_3901_3908.

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CD44 is the major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan and is implicated in a variety of biological events that include embryonic morphogenesis, lymphocyte recirculation, inflammation, and tumor metastasis. CD44 delivers activation signals to T lymphocytes, B lymphocytes, natural killer cells, polymorphonuclear leukocytes, and macrophages by stimulating protein tyrosine phosphorylation and calcium influx. The mechanism of signal transduction via CD44 remains undefined, although CD44 was shown to physically associate with intracellular protein tyrosine

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4

Shimonaka, Mika, Koko Katagiri, Toshinori Nakayama, et al. "Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow." Journal of Cell Biology 161, no. 2 (2003): 417–27. http://dx.doi.org/10.1083/jcb.200301133.

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Chemokines arrest circulating lymphocytes within the vasculature through the rapid up-regulation of leukocyte integrin adhesive activity, promoting subsequent lymphocyte transmigration. However, the key regulatory molecules regulating this process have remained elusive. Here, we demonstrate that Rap1 plays a pivotal role in chemokine-induced integrin activation and migration. Rap1 was activated by secondary lymphoid tissue chemokine (SLC; CCL21) and stromal-derived factor 1 (CXCL4) treatment in lymphocytes within seconds. Inhibition of Rap1 by Spa1, a Rap1-specific GTPase-activating protein, a

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5

Mun, Yeung-Chul, Kyoung-Eun Lee, Jung Mi Kwon, et al. "Establishment of Effective B Lymphocyte Ex Vivo Expansion on Human Cord Blood Using TPO, SCF, FL, IL-4, IL-10, and CD40L." Blood 104, no. 11 (2004): 2882. http://dx.doi.org/10.1182/blood.v104.11.2882.2882.

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Abstract In respect to B lymphocyte-mediated immunity, characteristics of human cord blood are low counts of mature B lymphocytes, deficient expression of CD40L and cytokine production in CD4+ T lymphocytes, defect in the isotype switch of immunoglobulin and the activation of B lymphocytes, and low IgG production of B lymphocytes. These characteristics of the B lymphocyte from human cord blood lead to a delayed B lymphocyte-mediated immune reconstitution and an increased susceptibility to infections after a cord blood transplantation. The mechanism of immunological recostitution after cord blo

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6

Zhang, Jinyi, Amro Shehabeldin, Luis A. G. da Cruz, et al. "Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes." Journal of Experimental Medicine 190, no. 9 (1999): 1329–42. http://dx.doi.org/10.1084/jem.190.9.1329.

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The Wiskott-Aldrich syndrome protein (WASp) has been implicated in modulation of lymphocyte activation and cytoskeletal reorganization. To address the mechanisms whereby WASp subserves such functions, we have examined WASp roles in lymphocyte development and activation using mice carrying a WAS null allele (WAS−/−). Enumeration of hemopoietic cells in these animals revealed total numbers of thymocytes, peripheral B and T lymphocytes, and platelets to be significantly diminished relative to wild-type mice. In the thymus, this abnormality was associated with impaired progression from the CD44−CD

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7

Zöller, M. "CD44, metastatic tumor spread, lymphocyte activation." Biomedicine & Pharmacotherapy 47, no. 4 (1993): 174. http://dx.doi.org/10.1016/0753-3322(93)90013-b.

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8

Maltzman, J. S., J. A. Carman, and J. G. Monroe. "Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes." Molecular and Cellular Biology 16, no. 5 (1996): 2283–94. http://dx.doi.org/10.1128/mcb.16.5.2283.

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The immediate-early gene egr-1 encodes a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream activation events through the regulation of previously unidentified target genes. Here we identify the gene encoding the lymphocyte homing and migration protein CD44 as a target of EGR1 regulation in B cells. BCR-induced increases in CD44 mRNA expression and transcription levels are shown to occur in EGR1-expressing but not in nonexpressing subclones of the B-cell line WEHI-231. Kinetics of egr-1 transcription and the appearance of nuclear EGR1 protein precede CD4

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9

Forster, R., T. Emrich, E. Kremmer, and M. Lipp. "Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells." Blood 84, no. 3 (1994): 830–40. http://dx.doi.org/10.1182/blood.v84.3.830.bloodjournal843830.

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The G-protein-coupled receptor BLR1 related to receptors for chemokines and neuropeptides has been identified as the first lymphocyte-specific member of the gene family characterized by seven transmembrane-spanning regions. Using a high-affinity anti-BLR1 monoclonal antibody (MoAb) and three-color flow cytometry it is shown that BLR1 expression on peripheral blood cells is limited to B cells and to a subset of CD4+ (14%) and CD8+ (2%) lymphocytes. T cells expressing BLR1 were positive for CD45R0, were negative for interleukin-2 receptors, show high levels of CD44, and show low levels of L-sele

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10

Murakami, S., and H. Okada. "Lymphocyte-Fibroblast Interactions." Critical Reviews in Oral Biology & Medicine 8, no. 1 (1997): 40–50. http://dx.doi.org/10.1177/10454411970080010201.

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Chronic inflammatory reactions are usually characterized by inflammatory cell accumulation in the extravascular connective tissue. In such sites, inappropriate activation of circulating or resident lymphocytes becomes self-perpetuating and can lead to chronic tissue destruction. In addition to that, the locally infiltrated lymphocytes should have an opportunity to interact directly with fibroblasts composing the connective tissue. The direct interactions of those different cell types seem to play important roles in lymphocyte lodging and retention in such sites. Thus, for clarification of the

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11

Forster, R., T. Emrich, E. Kremmer, and M. Lipp. "Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells." Blood 84, no. 3 (1994): 830–40. http://dx.doi.org/10.1182/blood.v84.3.830.830.

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Abstract The G-protein-coupled receptor BLR1 related to receptors for chemokines and neuropeptides has been identified as the first lymphocyte-specific member of the gene family characterized by seven transmembrane-spanning regions. Using a high-affinity anti-BLR1 monoclonal antibody (MoAb) and three-color flow cytometry it is shown that BLR1 expression on peripheral blood cells is limited to B cells and to a subset of CD4+ (14%) and CD8+ (2%) lymphocytes. T cells expressing BLR1 were positive for CD45R0, were negative for interleukin-2 receptors, show high levels of CD44, and show low levels

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12

Grossman, William J., James W. Verbsky, Benjamin L. Tollefsen, Claudia Kemper, John P. Atkinson, and Timothy J. Ley. "Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells." Blood 104, no. 9 (2004): 2840–48. http://dx.doi.org/10.1182/blood-2004-03-0859.

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Abstract Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway as a major mechanism to kill pathogen-containing cells and tumor cells.1,2 Dysregulation of this pathway results in several human diseases, such as hemophagocytic lymphohistiocytosis. Here we characterize the single-cell expression pattern of granzymes A and B in human lymphocytes using a flow cytometry-based assay. We demonstrate that most circulating CD56+8- NK cells, and approximately half of circulating CD8+ T lymphocytes, coexpressed both granzymes A and B. In contrast, few circulating

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13

Fatmawati, Fatmawati, Ellyza Nasrul, Nasrul Zubir, and Ferry Sandra. "Programmed Cell Death Protein 1-overexpressed CD8+ T Lymphocytes Play a Role in Increasing Chronic Hepatitis B Disease Progression." Indonesian Biomedical Journal 13, no. 3 (2021): 310–5. http://dx.doi.org/10.18585/inabj.v13i3.1601.

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BACKGROUND: T lymphocyte activation depends on the balance of co-stimulatory and co-inhibitory signals determined by Cluster of Diffrentiation (CD)28 and Programmed Cell Death Protein 1 (PD-1) expression. Alteration in CD28 and PD-1 expression might affect the progression of chronic hepatitis B (CHB). Current study was conducted to evaluate the correlations of the CD28 and PD-1 expressions of T lymphocytes and CHB progression.METHODS: Subjects were recruited, selected and divided into 3 groups, inactive CHB, active CHB and CHB with End-Stage Liver Disease (ESLD). HBeAg was determined by using

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14

Perico, N., D. Ostermann, M. Bontempeill, et al. "Colchicine interferes with L-selectin and leukocyte function-associated antigen-1 expression on human T lymphocytes and inhibits T cell activation." Journal of the American Society of Nephrology 7, no. 4 (1996): 594–601. http://dx.doi.org/10.1681/asn.v74594.

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Colchicine, which inhibits cell microtubule assembly by preventing polymerization of tubulin monomers, inhibits cell-mediated immune responses and promotes long-term survival of major histocompatibility complex-incompatible renal allografts in rats. Here we evaluated the effect of blocking cell microtubule assembly by colchicine on T cell and endothelial cell adhesion receptors involved in transducing signals for T cell activation. By using immunofluorescence flow cytometry analysis, evidence is presented that colchicine, in a dose-dependent fashion, downregulated L-selectin and leukocyte func

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15

DeGrendele, H. C., P. Estess, L. J. Picker, and M. H. Siegelman. "CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway." Journal of Experimental Medicine 183, no. 3 (1996): 1119–30. http://dx.doi.org/10.1084/jem.183.3.1119.

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The extravasation of leukocytes from the blood into tissues occurs as a multistep process: an initial transient interaction ("rolling"), generally thought to be mediated by the selectin family of adhesion molecules, followed by firm adhesion, usually mediated by integrins. Using a parallel plate flow chamber designed to approximate physiologic flow in postcapillary venules, we have characterized a rolling interaction between lymphoid cells and adherent primary and cultured endothelial cells that is not selectin mediated. Studies using blocking monoclonal antibodies indicate that this novel int

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16

Waters, W. R., T. E. Rahner, M. V. Palmer, D. Cheng, B. J. Nonnecke, and D. L. Whipple. "Expression of l-Selectin (CD62L), CD44, and CD25 on Activated Bovine T Cells." Infection and Immunity 71, no. 1 (2003): 317–26. http://dx.doi.org/10.1128/iai.71.1.317-326.2003.

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ABSTRACT Mycobacterium bovis infection of cattle represents a natural host-pathogen interaction and, in addition to its economic and zoonotic impact, represents a model for human tuberculosis. Extravasation and trafficking of activated lymphocytes to inflammatory sites is modulated by differential expression of multiple surface adhesion molecules. However, effects of M. bovis infection on adhesion molecule expression have not been characterized. To determine these changes, peripheral blood mononuclear cells from M. bovis-infected cattle were stimulated with M. bovis purified protein derivative

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17

Sandmaier, BM, R. Storb, FR Appelbaum, and WM Gallatin. "An antibody that facilitates hematopoietic engraftment recognizes CD44." Blood 76, no. 3 (1990): 630–35. http://dx.doi.org/10.1182/blood.v76.3.630.630.

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Abstract Pretreatment of recipients with the monoclonal antibody (MoAb) S5 facilitates engraftment of bone marrow from mismatched, unrelated donors in the canine transplantation model. In the direct comparisons reported here, the S5 glycoprotein (gp) was found to have structural homology to CD44 that in humans has been implicated in adhesive interactions of one type of effector cell, the lymphocyte. The S5 antigen and gp90Hermes-1 exhibited codistribution on canine peripheral blood cells. Both S5 and Hermes-1 (anti-CD44) MoAbs recognized 90-Kd species in radioimmune precipitations of 125I surf

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18

Sandmaier, BM, R. Storb, FR Appelbaum, and WM Gallatin. "An antibody that facilitates hematopoietic engraftment recognizes CD44." Blood 76, no. 3 (1990): 630–35. http://dx.doi.org/10.1182/blood.v76.3.630.bloodjournal763630.

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Pretreatment of recipients with the monoclonal antibody (MoAb) S5 facilitates engraftment of bone marrow from mismatched, unrelated donors in the canine transplantation model. In the direct comparisons reported here, the S5 glycoprotein (gp) was found to have structural homology to CD44 that in humans has been implicated in adhesive interactions of one type of effector cell, the lymphocyte. The S5 antigen and gp90Hermes-1 exhibited codistribution on canine peripheral blood cells. Both S5 and Hermes-1 (anti-CD44) MoAbs recognized 90-Kd species in radioimmune precipitations of 125I surface-label

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19

Högerkorp, Carl-Magnus, Sven Bilke, Thomas Breslin, Sigurdur Ingvarsson, and Carl A. K. Borrebaeck. "CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays." Blood 101, no. 6 (2003): 2307–13. http://dx.doi.org/10.1182/blood-2002-06-1837.

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A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center–like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies.

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20

Bleul, Conrad C., Joachim L. Schultze, and Timothy A. Springer. "B Lymphocyte Chemotaxis Regulated in Association with Microanatomic Localization, Differentiation State, and B Cell Receptor Engagement." Journal of Experimental Medicine 187, no. 5 (1998): 753–62. http://dx.doi.org/10.1084/jem.187.5.753.

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Migration of mature B lymphocytes within secondary lymphoid organs and recirculation between these sites are thought to allow B cells to obtain T cell help, to undergo somatic hypermutation, to differentiate into effector cells, and to home to sites of antibody production. The mechanisms that direct migration of B lymphocytes are unknown, but there is evidence that G protein–coupled receptors, and possibly chemokine receptors, may be involved. Stromal cell– derived factor (SDF)-1α is a CXC chemokine previously characterized as an efficacious chemoattractant for T lymphocytes and monocytes in p

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21

Hertweck, Magdalena, Felix Erdfelder, Alexandra Filipovich, et al. "Evidence for a Pathological Ratio of CD44s/CD44v6 in Chronic Lymphoctic Leukemia (CLL) Cells." Blood 114, no. 22 (2009): 2628. http://dx.doi.org/10.1182/blood.v114.22.2628.2628.

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Abstract Abstract 2628 Poster Board II-604 Chronic Lymphocytic Leukemia (CLL) is the most common adult-onset leukemia in the western world. It is characterized by an accumulation of functionally incompetent monoclonal CD5+ B-lymphocytes and an increased resistance to apoptosis. CD44 is a cell surface transmembrane glycoprotein which has more than ten isoforms generated by alternative splicing. It is expressed on different cells as e.g. cells of lymphohematopoietic origin, epithelial cells and keratinocytes. CD44 is involved in lymphocyte activation, recirculation and homing. It acts as an adhe

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22

Greil, Johann, Tobias Rausch, Thomas Giese, et al. "Whole-Exome Sequencing Links CARD11 Inactivation with SCID." Blood 120, no. 21 (2012): 258. http://dx.doi.org/10.1182/blood.v120.21.258.258.

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Abstract Abstract 258 Primary immunodeficiencies represent model diseases for the mechanistic understanding of the human innate and the adaptive immune response and are per se clinically highly relevant, because in SCID patients infections by opportunistic pathogens are typically life-threatening early in life. We identified an infant of consanguineous parents suffering from a novel form of SCID, who presented with a life-threatening Pneumocystis jirovecii pneumonia. This entity was characterized by agammaglobulinemia and profoundly deficient T-cell function despite quantitatively normal T- an

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23

Hoshino, Yoshihiko, Koh Nakata, Satomi Hoshino, et al. "Maximal HIV-1 Replication in Alveolar Macrophages during Tuberculosis Requires both Lymphocyte Contact and Cytokines." Journal of Experimental Medicine 195, no. 4 (2002): 495–505. http://dx.doi.org/10.1084/jem.20011614.

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HIV-1 replication is markedly upregulated in alveolar macrophages (AM) during pulmonary tuberculosis (TB). This is associated with loss of an inhibitory CCAAT enhancer binding protein β (C/EBPβ) transcription factor and activation of nuclear factor (NF)-κB. Since the cellular immune response in pulmonary TB requires lymphocyte–macrophage interaction, a model system was developed in which lymphocytes were added to AM. Contact between lymphocytes and AM reduced inhibitory C/EBPβ, activated NF-κB, and enhanced HIV-1 replication. If contact between lymphocytes and macrophages was prevented, inhibi

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24

Maltzman, J. S., J. A. Carmen, and J. G. Monroe. "Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1." Journal of Experimental Medicine 183, no. 4 (1996): 1747–59. http://dx.doi.org/10.1084/jem.183.4.1747.

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Intercellular adhesion molecule (ICAM) 1/CD54 plays an important role in T cell dependent B cell activation and for function of B lymphocytes as antigen-presenting cells. ICAM-1 expression is upregulated as a consequence of B lymphocyte antigen receptor (BCR) signaling, thereby serving to render antigen-stimulated B cells more receptive to T cell-mediated costimulatory signals. We have investigated BCR-induced expression of the Icam-1 gene in primary B cells and B cell lines and have found it to be dependent on BCR-induced expression of the transcription factor EGR1. Icam-1 transcription, indu

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25

Qiao, Zhenhua, Fang Ye, Tao Yang, Li Zhang, and Ning Jia. "The Effect of Mesenchymal Stem Cells on Preventing Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation—the Effect of Mesenchymal Stem Cells on Active T Lymphocytes(in vitro)." Blood 116, no. 21 (2010): 5182. http://dx.doi.org/10.1182/blood.v116.21.5182.5182.

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Abstract Abstract 5182 Objective To study the immune regulatory effects of human bone marrow Mesenchymal stem cells(MSCs) on active T lymphocytes in vitro and to explore the new strategy to prevent Graft-Versus-Host Disease(GVHD) in allogeneic hematopoietic stem cell transplantation(allo-HSCT). Methods 1. Mononuclear cells from human peripheral blood cells were isolated and cultured in the presence of phytohemagglutinin (PHA) (final concentration was 10μ g/ml) for different time (24hours, 36hours, 48hours, 72hours). 2. The ability of T lymphocyte proliferation and activation was measured by 3H

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26

Serrador, Juan M., José L. Alonso-Lebrero, Miguel A. del Pozo, et al. "Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization." Journal of Cell Biology 138, no. 6 (1997): 1409–23. http://dx.doi.org/10.1083/jcb.138.6.1409.

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During activation, T lymphocytes become motile cells, switching from a spherical to a polarized shape. Chemokines and other chemotactic cytokines induce lymphocyte polarization with the formation of a uropod in the rear pole, where the adhesion receptors intercellular adhesion molecule-1 (ICAM-1), ICAM-3, and CD44 redistribute. We have investigated membrane–cytoskeleton interactions that play a key role in the redistribution of adhesion receptors to the uropod. Immunofluorescence analysis showed that the ERM proteins radixin and moesin localized to the uropod of human T lymphoblasts treated wi

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27

Billard, Christian, Stéphanie Delaire, Emmanuel Raffoux, Armand Bensussan, and Laurence Boumsell. "Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage." Blood 95, no. 3 (2000): 965–72. http://dx.doi.org/10.1182/blood.v95.3.965.003k39_965_972.

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Human CD100, the first semaphorin identified in the immune system, is a transmembrane protein involved in T-cell activation. In the present study, we showed that activation of peripheral blood or tonsillar B lymphocytes induced the expression of CD100 in CD38+CD138− cell populations, including in CD148+ subpopulations, thus expressing a memory B-cell–like phenotype. Using an in vitro enzymatic assay, we found that protein tyrosine phosphatase (PTP) activities were immunoprecipitated with CD100 in these cell populations, which were isolated by cell sorting, as well as in most B-cell lines repre

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28

Galibert, L., N. Burdin, C. Barthélémy, et al. "Negative selection of human germinal center B cells by prolonged BCR cross-linking." Journal of Experimental Medicine 183, no. 5 (1996): 2075–85. http://dx.doi.org/10.1084/jem.183.5.2075.

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The antigen receptors on T and B lymphocytes can transduce both agonist and antagonist signals leading either to activation/survival or anergy/death. The outcome of B lymphocyte antigen receptor (BCR) triggering depends upon multiple parameters which include (a) antigen concentration and valency, (b) duration of BCR occupancy, (c) receptor affinity, and (d) B cell differentiation stages. Herein, using anti-immunoglobulin kappa and lambda light chain antibodies, we analyzed the response of human naive, germinal center (GC) or memory B cells to BCR cross-linking regardless of heavy chain Ig isot

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29

Rafi, Asimah, Mitzi Nagarkatti, and Prakash S. Nagarkatti. "Hyaluronate-CD44 Interactions Can Induce Murine B-Cell Activation." Blood 89, no. 8 (1997): 2901–8. http://dx.doi.org/10.1182/blood.v89.8.2901.

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Abstract CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified as hyaluronic acid (HA), a major component of the extracellular matrix (ECM). Recent studies have demonstrated that activation through CD44 leads to induction of effector function in T cells and macrophages. In the current study, we investigated whether HA or monoclonal antibodies (MoAbs) against CD44 would induce a proliferative response in mouse lymphocytes. Spleen cells from normal and nude, but not severe combined immunodeficient mice, exhibited strong proliferative responsiveness to

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30

Krinzman, S. J., G. T. De Sanctis, M. Cernadas, et al. "T cell activation in a murine model of asthma." American Journal of Physiology-Lung Cellular and Molecular Physiology 271, no. 3 (1996): L476—L483. http://dx.doi.org/10.1152/ajplung.1996.271.3.l476.

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To determine the mechanisms by which inhaled antigens produce pulmonary inflammation and bronchial hyperreactivity, we have developed a murine model of asthma. BALB/c mice are sensitized and challenged with ovalbumin (OVA). Compared with mice treated with phosphate-buffered saline (PBS), OVA-treated mice developed increased lung resistance, decreased dynamic compliance, and greater methacholine reactivity. Bronchoalveolar lavage fluid revealed significant increases in the proportion of neutrophils and eosinophils. Tissue sections of OVA-treated mice demonstrated goblet cell metaplasia and foca

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Nakayama, K., K. Nakayama, L. B. Dustin, and D. Y. Loh. "T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice." Journal of Experimental Medicine 182, no. 4 (1995): 1101–9. http://dx.doi.org/10.1084/jem.182.4.1101.

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Bcl-2 expression is tightly regulated during lymphocyte development. Mature lymphocytes in Bcl-2-deficient mice show accelerated spontaneous apoptosis in vivo and in vitro. Stimulation of Bcl-2-deficient lymphocytes by anti-CD3 antibody inhibited the spontaneous apoptosis not only in T cells but also in B cells. The rescue of B cells was dependent on the presence of T cells, mainly through CD40L and interleukin (IL)-4. Furthermore, we generated Bcl-2-deficient mice transgenic for a T cell receptor or an immunoglobulin, both specific for chicken ovalbumin, to test for antigen-specific T-B cell

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32

Ravanel, Kissia, Claire Castelle, Thierry Defrance та ін. "Measles Virus Nucleocapsid Protein Binds to FcγRII and Inhibits Human B Cell Antibody Production". Journal of Experimental Medicine 186, № 2 (1997): 269–78. http://dx.doi.org/10.1084/jem.186.2.269.

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Despite the development of an efficient specific immune response during measles virus (MV) infection, an immunosuppression occurs contributing to secondary infections. To study the role of nucleocapsid protein (NP) in MV-induced immunosuppression, we produced recombinant MV NP. Purified recombinant NP exhibited biochemical, antigenic, and tridimensional structure similar to viral NP. By flow cytometry, we showed that viral or recombinant NP bound to human and murine B lymphocytes, but not to T lymphocytes. This binding was specific, independent of MHC class II expression, and dependent of the

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33

Zanetta, J. P., J. Wantyghem, S. Kuchler-Bopp, A. Badache, and M. Aubery. "Human lymphocyte activation is associated with the early and high-level expression of the endogenous lectin CSL at the cell surface." Biochemical Journal 311, no. 2 (1995): 629–36. http://dx.doi.org/10.1042/bj3110629.

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Lymphocytes undergo activation in response to antigens, cytokines, lectins and antibodies interacting with specific cell-surface molecules or through substances influencing signal transduction pathways. This study shows that human T- and B-cells stimulated using phorbol esters or plant lectins express early (2 h using phorbol esters and 24 h using plant lectins) a high level of a polyvalent carbohydrate-binding protein, the cerebellar soluble lectin (CSL), which is in part externalized. The lectin, immunologically related to CDw70, interacts with specific glycoprotein ligands of the lymphocyte

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Galli, Grazia, Sandra Nuti, Simona Tavarini, et al. "CD1d-restricted Help To B Cells By Human Invariant Natural Killer T Lymphocytes." Journal of Experimental Medicine 197, no. 8 (2003): 1051–57. http://dx.doi.org/10.1084/jem.20021616.

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Invariant natural killer T (NKT) cells are a highly conserved subset of T lymphocytes expressing a semi-invariant T cell receptor (TCR), which is restricted to CD1d and specific for the glycosphingolipid antigen α-galactosylceramide. Their ability to secrete a variety of cytokines, which in turn modulate the activation of cells of both innate and acquired immune responses, suggests that invariant NKT cells exert a regulatory role mainly via indirect mechanisms. A relevant question is whether invariant NKT cells can directly help B cells. We document here that human invariant NKT cells are as e

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Rossini, Aldo A., David C. Parker, Nancy E. Phillips, et al. "Induction of Immunological Tolerance to Islet Allografts." Cell Transplantation 5, no. 1 (1996): 49–52. http://dx.doi.org/10.1177/096368979600500109.

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T-cell dependent activation of resting B cells involves the interaction of gp39 on T cells with its receptor, CD40, on B cells. We administered either a combination of T-cell-depleted splenic lymphocytes and anti-gp39 monoclonal antibody or antibody alone to establish islet allografts in mice without continuous immunosuppression. Fully allogeneic H-2q FVB islets were permanently accepted by chemically diabetic H-2b C57BL/6 mice provided that the recipients were pretreated with both T-cell-depleted donor spleen cells and anti-gp39 antibody. Antibody alone was less effective in prolonging allogr

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Imbert, V., J. F. Peyron, D. Farahi Far, B. Mari, P. Auberger, and B. Rossi. "Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases." Biochemical Journal 297, no. 1 (1994): 163–73. http://dx.doi.org/10.1042/bj2970163.

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Rapid tyrosine phosphorylation of key cellular proteins is a crucial event in the transduction of activation signals to T-lymphocytes. The regulatory role of protein tyrosine phosphatases (PTPases) in this process was explored by studying the effects of a powerful PTPase inhibitor, vanadate peroxide (pervanadate), on the activation cascade of Jurkat human leukaemic T-cells. Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in tyrosine phosphorylation of cellular proteins, notably phospholipase C gamma 1. After this event, we

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van der Voort, Robbert, Robert M. J. Keehnen, Esther A. Beuling, Marcel Spaargaren, and Steven T. Pals. "Regulation of Cytokine Signaling by B Cell Antigen Receptor and Cd40-Controlled Expression of Heparan Sulfate Proteoglycans." Journal of Experimental Medicine 192, no. 8 (2000): 1115–24. http://dx.doi.org/10.1084/jem.192.8.1115.

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Recently, biochemical, cell biological, and genetic studies have converged to reveal that integral membrane heparan sulfate proteoglycans (HSPGs) are critical regulators of growth and differentiation of epithelial and connective tissues. As a large number of cytokines involved in lymphoid tissue homeostasis or inflammation contain potential HS-binding domains, HSPGs presumably also play important roles in the regulation of the immune response. In this report, we explored the expression, regulation, and function of HSPGs on B lymphocytes. We demonstrate that activation of the B cell antigen rec

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Balakhonov, S. V., V. I. Dubrovina, V. V. Voitkova, et al. "Immunophenotyping of blood cells of experimental animals immunized with Brucella abortus thermoextracts." Journal of microbiology epidemiology immunobiology, no. 4 (September 2, 2019): 25–31. http://dx.doi.org/10.36233/0372-9311-2019-4-25-31.

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Aim. To study the subpopulational structure of blood cells of the experimental animals immunized with thermoextracts (TE) of Brucella abortus in L- and S-form. Materials and methods. Total 100 certified («Vector», Novosibirsk) outbred mice were immunized with B. abortus I-206 TE in L- and S-form in 20 μg protein dose. After 1, 3, 7, 14 and 21 days of observation the phenotypes (CD45, CD3, CD4, CD8, CD19, CD69) of blood cells were detected. Results. General regularities were revealed after injection of the experimental preparations. So, B. abortus TE in L- and S-form caused the immune response

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Maynadie, Marc M., Romain Casey, Karine Piazzon, Jean Claude Capiod, and Paule-Marie Carli. "Peripheral Blood Lymphocytes Subpopulations and Apoptotic Markers in Patients with Lymphoid Malignancies and in Controls: An Epidemiologic Case-Control Study." Blood 104, no. 11 (2004): 3858. http://dx.doi.org/10.1182/blood.v104.11.3858.3858.

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Abstract Few references ranges of normal peripheral blood lymphocytes subpopulations are available in the literature and fewer data were available regarding activation, proliferation and apoptosis antigen expression on such populations. We studied these parameters in patients included in an epidemiologic case-control study on risk factors of lymphoid malignancies conducted within European countries. Cell surface staining of peripheral blood lymphocyte antigens were analysed by multicolour flow cytometry in 300 cases and 300 controls. We determined CD3+, CD3+/CD4+, CD3+/CD8+, CD3−/CD56+CD16+, C

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Cooke, M. P., A. W. Heath, K. M. Shokat, et al. "Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells." Journal of Experimental Medicine 179, no. 2 (1994): 425–38. http://dx.doi.org/10.1084/jem.179.2.425.

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The specificity of antibody (Ab) responses depends on focusing helper T (Th) lymphocyte signals to suitable B lymphocytes capable of binding foreign antigens (Ags), and away from nonspecific or self-reactive B cells. To investigate the molecular mechanisms that prevent the activation of self-reactive B lymphocytes, the activation requirements of B cells specific for the Ag hen egg lysozyme (HEL) obtained from immunoglobulin (Ig)-transgenic mice were compared with those of functionally tolerant B cells isolated from Ig-transgenic mice which also express soluble HEL. To eliminate the need for su

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Kazantseva, E. V., N. V. Dolgushina, and P. P. Tereshkov. "FAS-receptor expression in peripheral blood lymphocytes and monocytes in pregnant women with fetal growth restriction." Kazan medical journal 95, no. 4 (2014): 511–15. http://dx.doi.org/10.17816/kmj1832.

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Aim. To study the expression of Fas-receptor on peripheral blood monocytes and lymphocytes in women who have given birth to children with low birth weight. Methods. Population-based study recruited 242 women who have given birth at the gestation term of more than 35 weeks. Group 1 (n=108) included mother-newborn pairs with low birth weight of newborns, group 2 (n=134) - mother-newborn pairs with normal birth weight for the gestational age. Peripheral blood lymphocytes and monocytes total count and subpopulations, CD95 (Fas-receptor) apoptosis receptor expression level (using four- and five-par

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Devergne, O., E. Hatzivassiliou, K. M. Izumi, et al. "Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation." Molecular and Cellular Biology 16, no. 12 (1996): 7098–108. http://dx.doi.org/10.1128/mcb.16.12.7098.

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The Epstein-Barr virus (EBV) transforming protein LMP1 appears to be a constitutively activated tumor necrosis factor receptor (TNFR) on the basis of an intrinsic ability to aggregate in the plasma membrane and an association of its cytoplasmic carboxyl terminus (CT) with TNFR-associated factors (TRAFs). We now show that in EBV-transformed B lymphocytes most of TRAF1 or TRAF3 and 5% of TRAF2 are associated with LMP1 and that most of LMP1 is associated with TRAF1 or TRAF3. TRAF1, TRAF2, and TRAF3 bind to a single site in the LMP1 CT corresponding to amino acids (aa) 199 to 214, within a domain

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Réthi, Bence, Péter Gogolák, Istvan Szatmari, et al. "SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells." Blood 107, no. 7 (2006): 2821–29. http://dx.doi.org/10.1182/blood-2005-06-2265.

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AbstractSignaling lymphocyte activation molecule (SLAM, CD150, or SLAMF1) is a self-ligand receptor on the surface of activated T- and B-lymphocytes, macrophages, and dendritic cells (DCs). Here we examine the effect of SLAM/SLAM interactions on CD40L-induced CD40 signaling pathways in human DCs. CD40L-expressing L929 cells induced DCs to produce interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-12, which was strongly inhibited by coexpression of SLAM on the surface of the L929 cells. Similarly, transfection of DCs with SLAM strongly reduced CD40L-induced IL-12 production. Furtherm

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Lee, Jong-Hwan, Tomoya Katakai, Takahiro Hara, Hiroyuki Gonda, Manabu Sugai, and Akira Shimizu. "Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation." Journal of Cell Biology 167, no. 2 (2004): 327–37. http://dx.doi.org/10.1083/jcb.200403091.

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Front–rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which several proteins, including CD44 and ezrin/radixin/moesin (ERM), are concentrated. In EL4.G8 T-lymphoma cells, Thr567 phosphorylation in the COOH-terminal domain of ezrin regulates the selective localization of ezrin in the uropod. Overexpression of the phosphorylation-mimetic T567D ezrin enhances uropod size and cell migration. T567D ezrin also induces construction of the CD44-associated polar cap, which covers the posterior cytoplasm in st

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Rohon, Peter, Kimmo Porkka, and Satu Mustjoki. "Differential Effects of Imatinib and Dasatinib On Immune Effector Cells in Patients with Chronic Myeloid Leukemia (CML)." Blood 114, no. 22 (2009): 3285. http://dx.doi.org/10.1182/blood.v114.22.3285.3285.

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Abstract Abstract 3285 Poster Board III-1 Introduction. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL oncoprotein are the current standard care of patients with CML. They also inhibit off-target kinases (e.g. c-KIT, TEC, BTK, PDGFR, SRC), some of which may have important physiological functions in immune responses. Recently, several papers have indicated a significant suppressive effect of TKIs on T- and NK-cell activation and cytotoxicity in vitro. The aim of this study was to assess the effects of TKIs on immune effector cells in patients with CML in chronic phase. Patients and met

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Boumedine, Radia Sidi, Gorazd Krosl, Marc Vaillancourt, Claude Perreault, and Denis-Claude Roy. "Specific Elimination of Alloreactive T Lymphocytes Using Photodynamic Therapy Prevents GVHD and Enables Rapid Immune Reconstitution." Blood 104, no. 11 (2004): 4987. http://dx.doi.org/10.1182/blood.v104.11.4987.4987.

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Abstract Graft-versus-host disease (GVHD) and impaired immune reconstitution are the primary obstacles limiting the efficacy of allogeneic stem cell transplantation (SCT). Graft-versus-host disease (GVHD) and impaired immune reconstitution are the primary obstacles limiting the efficacy of allogeneic stem cell transplantation (SCT). The purpose of this study was to determine whether selective depletion of donor alloantigen-specific T lymphocytes using photodynamic therapy (PDT) would prevent GVHD and enable immune reconstitution in the context of MHC-mismatched SCT. This question was addressed

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Chiang, Elaine Y., Andres Hidalgo, Jungshan Chang, and Paul S. Frenette. "Real-Time Identification of Leukocyte Subsets and Cell Surface Receptor Microdomains in the Microvasculature of Wild-Type and Sickle Cell Mice In Vivo." Blood 108, no. 11 (2006): 1229. http://dx.doi.org/10.1182/blood.v108.11.1229.1229.

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Abstract Intravital microscopy has contributed enormously to the recent mechanistic advances in leukocyte (WBC) trafficking. However, current methods have provided little knowledge about differential WBC subset behavior or the spatial redistribution of surface adhesion molecules during recruitment and activation. Here, we use digital high-speed multichannel fluorescence intravital videomicroscopy to identify WBCs and localize cell surface molecules. Adherent WBCs were ascertained using a series of near-simultaneous 4-channel images in randomly selected venular segments following the injection

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del Pozo, M. A., P. Sánchez-Mateos, M. Nieto, and F. Sánchez-Madrid. "Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway." Journal of Cell Biology 131, no. 2 (1995): 495–508. http://dx.doi.org/10.1083/jcb.131.2.495.

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Leukocyte recruitment is a key step in the inflammatory reaction. Several changes in the cell morphology take place during lymphocyte activation and migration: spheric-shaped resting T cells become polarized during activation, developing a well defined cytoplasmic projection designated as cellular uropod. We found that the chemotactic and proinflammatory chemokines RANTES, MCP-1, and, to a lower extent, MIP-1 alpha, MIP-1 beta, and IL-8, were able to induce uropod formation and ICAM-3 redistribution in T lymphoblasts adhered to ICAM-1 or VCAM-1. A similar chemokine-mediated effect was observed

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Hao, Jian-Jiang, Yin Liu, Michael Kruhlak, Karen E. Debell, Barbara L. Rellahan, and Stephen Shaw. "Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane." Journal of Cell Biology 184, no. 3 (2009): 451–62. http://dx.doi.org/10.1083/jcb.200807047.

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Mechanisms controlling the disassembly of ezrin/radixin/moesin (ERM) proteins, which link the cytoskeleton to the plasma membrane, are incompletely understood. In lymphocytes, chemokine (e.g., SDF-1) stimulation inactivates ERM proteins, causing their release from the plasma membrane and dephosphorylation. SDF-1–mediated inactivation of ERM proteins is blocked by phospholipase C (PLC) inhibitors. Conversely, reduction of phosphatidylinositol 4,5-bisphosphate (PIP2) levels by activation of PLC, expression of active PLC mutants, or acute targeting of phosphoinositide 5-phosphatase to the plasma

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Gordeychuk, I. V., A. I. Tukhvatulin, S. P. Petkov, et al. "Assessment of the Parameters of Adaptive Cell-Mediated Immunity in Naïve Common Marmosets (Callithrix jacchus)." Acta Naturae 10, no. 4 (2018): 63–69. http://dx.doi.org/10.32607/20758251-2018-10-4-63-69.

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Common marmosets are small New World primates that have been increasingly used in biomedical research. This report presents efficient protocols for assessment of the parameters of adaptive cell-mediated immunity in common marmosets, including the major subpopulations of lymphocytes and main markers of T- and B-cell maturation and activation using flow cytometry with a multicolor panel of fluorescently labelled antibodies. Blood samples from eight common marmosets were stained with fluorescently labeled monoclonal antibodies against their population markers (CD45, CD3, CD20, CD4, CD8) and lymph

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