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Dissertations / Theses on the topic 'CD5'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Le, Dantec Christelle. "Intérêt du couple CD5/CD6 dans les lymphocytes B humains." Thesis, Brest, 2012. http://www.theses.fr/2012BRES0090.

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Issues d'un gène ancestral commun, les molécules CD5 et CD6 sont présentes à la surface de tous les lymphocytes T (LT) matures ainsi qu'à la surface de certains lymphocytes B (LB). Ces deux protéines font partie de la famille des « Scavenger Receptor Cystein Rich » (SRCR) protéines mais la régulation, l'expression et les fonctions de ces deux molécules ne sont pas totalement résolues. Ainsi, CD5 est impliquée dans la régulation du récepteur à l’antigène des LB et des LT, dans la tolérance des LB et elle est présente à la surface des LB régulateurs. A l’opposé, CD6 possède un rôle dans la proli

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2

Hassan, Namir. "Interactions of the leukocyte cell-surface proteins CD5 and CD6." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398158.

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3

Simões, Inês Tadeu dos Anjos. "Characterization of the in vivo immunomodulatory properties of CD5 and CD6." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/593499.

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Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- Rich superfamily, characterized by the presence of one or more cysteine rich domains. The interaction between CD6 and ALCAM, its principal ligand, is well established but recently more ligands of CD6 have been described. On the other hand, to date there is no consensus about the CD5 ligand/s, although several candidates have been proposed. Previous work carried out with CD5 and CD6-deficient

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4

Breuning, Johannes. "Molecular mechanisms of immune regulation by the receptors CD5 and CD6." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d5ac44af-e452-4561-854d-53901a78da93.

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T cells are adaptive immune cells that are essential for initiating and regulating immune responses. T cell activation is triggered by stimulation of the T cell receptor. However, sustained T cell activation requires the function of a variety of coreceptors, among them CD5 and CD6. Both receptors have been shown to have activating and inhibitory functions and modulation of CD6 function is dependent on engagement by its ligand CD166. Costimulatory signalling by CD6 involves a phosphorylation-dependent interaction between the C-terminal Y662 residue and the adaptor protein SLP-76. However, the C

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5

Bamberger, Martina. "CD5-Mediated inhibition of tlymphocyte signaling." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/7238.

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6

Bamberger, Martina. "CD5-Mediated inhibition of tlymphocyte signaling." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/7238.

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7

Morel, Patricia. "Administration d'anticorps monoclonaux anti-cd4 ou anti-cd5 en transplantation renale chez l'homme." Lyon 1, 1990. http://www.theses.fr/1990LYO1M170.

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8

Vilà, de las Heras Josep M. "Cinasas intracelulares y señalización mediada por CD5." Doctoral thesis, Universitat de Barcelona, 2001. http://hdl.handle.net/10803/853.

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El receptor linfocitario CD5 es una glicoproteína monomérica de membrana de 67KDa. Funcionalmente, es una molécula accesoria, implicada en la modulación de los procesos de activación y diferenciación mediados por el receptor antigénico en células T y B. Su región citoplasmática no contiene ninguna actividad catalítica intrínseca, pero en cambio presenta diversos motivos potenciales de fosforilación para serin/treonin y tirosincinasas, y otros motivos estructurales compatibles con una función señalizadora intracelular. Se ha demostrado que esta región se encuentra constitutivamente fosforilada

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9

Axtell, Robert C. "The role of CD5 in experimental autoimmune encephalitomyelitis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007p/axtell.pdf.

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10

Lacey, Erica. "The role of CD5 in T lymphocyte activation." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:c88d2845-4454-4b98-9814-64b9bbf22e04.

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11

Simões, Inês Tadeu dos Anjos. "Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6582.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>The CD5 and CD6 lymphocyte surface receptors are highly homologous members of the Scavenger Receptor Cystein Rich (SRCR) superfamily mainly expressed by all T lymphocytes and the B1a subpopulation of B cells. Although the ultimate function/s are far from being completely understood, CD5 and CD6 are known to play a relevant role in both lymphocyte development and differentiation by negatively modulating the survival/death-inducing intracellular signals generated during the antigen recognition. Recently, this g

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12

Renaudineau, Yves. "Régulation du gène CD5 dans les lymphocytes B humains." Brest, 2005. http://www.theses.fr/2005BRES3102.

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Les lymphocytes B (LB) CD5+ ou LB1 produisent des anticorps (Ac) polyréactifs de faible affinité. Pour cette raison ce sont d'efficaces cellules présentatrices d'antigène. Nous avons émis l'hypothèse que le contrôle négatif exercé par la molécule CD5 elle-même sur ces cellules pouvait être déficient chez ces malades. Nous avons donc étudié la régulation de ce gène dans les LB humains. L'analyse du génome a révélé chez les primates, mais pas chez la souris, l'insertion d'un rétrovirus endogène humain de type E (HERV-E) en amont du gène CD5. Cette insertion dont la date peut être estimée à 25 à

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13

Orta, Mascaró Marc. "Implicacions funcionals i terapèutiques de les interaccions moleculars mitjançades per CD5 i CD6 en les respostes immunitàries." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399678.

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Els receptors de superfície CD5 i CD6 són receptors altament homòlegs amb dominis tipus scavenger, expressats principalment als timòcits i cèl·lules T madures. Els dos es troben associats al receptor de cèl·lules T (TCR) actuant com a moduladors de les senyals transmeses a nivell intracel·lular. Pel que fa a CD5, s’ha pogut determinar en diferents estudis la seva funció com a modulador negatiu de la senyal del TCR en timòcits i cèl·lules T madures a través del seu domini citoplasmàtic. En canvi, la manca de models animals ha fet que el rol biològic de CD6 encara sigui una incògnita, tot i que

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14

Velasco, de Andrés María. "CD5 as immunomodulatory agent in experimental models of fungal infection." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671743.

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CD5 is a scavenger receptor mainly expressed on lymphoid (T and B1a) cells but also on some minor myeloid (Mϕ and DCs) cell subsets. It is long known to negatively modulate differentiation and activation signals mediated by the clonotypic antigen specific receptor complexes of T (TCR) and B1a (BCR) lymphocytes, both being an identity hallmark of the adaptive immune system (Burgueño‐Bucio et al., 2019). Recently, several reports have also shown its ability to recognise and signal the presence of PAMPs of fungal, viral and parasitic origin (Consuegra-Fernández et al., 2015; Burgueño‐Bucio et al

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15

Payne, Andrew Jordan. "The Effects of Alcohol on BDNF and CD5 Dependent Pathways." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8638.

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Alcohol represents the third leading cause of preventable death in the United States. Yet, despite its prevalent role in impeding human health, there is much to understand about how it elicits its effects on the body and how the body and brain change when an individual becomes physiologically dependent upon alcohol. The work presented herein represents an effort to elucidate the acute and chronic effects of alcohol on the nervous system. We investigate two specific protein pathways and their role in alcohol’s effects on the body. The first begins with brain-derived neurotrophic factor (BDNF),

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16

Pers, Jacques-Olivier. "La molécule CD5 : son rôle dans l'apoptose des lymphocytes B." Brest, 2002. http://www.theses.fr/2002BRES3101.

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17

Pinheiro, CatiÃssia Dantas. "CÃlulas CD3+, CD4+, CD8+, CD3-CD16+CD56+ e CD19+ em sangue perifÃrico de pacientes com hansenÃase e indivÃduos saudÃveis." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16323.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A hansenÃase Ã uma doenÃa granulomatosa, infecto-contagiosa causada pelo Mycobacterium leprae. Trata-se de uma infecÃÃo crÃnica com amplo espectro de respostas imunes celulares em humanos. Possui alto poder infectante e baixo poder patogÃnico. Este estudo tem como objetivo quantificar e comparar leucÃcitos e subpopulaÃÃes de linfÃcitos T totais (CD3+), T auxiliares (CD3+CD4+), T citotÃxicos (CD3+CD8+), B (CD19+) e NK (CD3-CD16+CD56+) em sangue perifÃrico de indivÃduos com hansenÃase e controles saudÃveis. Os pacientes foram prove

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18

Pinheiro, Catiússia Dantas. "Células CD3+, CD4+, CD8+, CD3-CD16+CD56+ e CD19+ em sangue periférico de pacientes com hanseníase e indivíduos saudáveis." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/15425.

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PINHEIRO, Catiússia Dantas. Células CD3+, CD4+, CD8+, CD3-CD16+CD56+ e CD19+ em sangue periférico de pacientes com hanseníase e indivíduos saudáveis. 2013. 65 f. Dissertação (Mestrado em Patologia) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2013.<br>Submitted by denise santos (denise.santos@ufc.br) on 2016-03-09T13:41:07Z No. of bitstreams: 1 2013_dis_cdpinheiro.pdf: 775643 bytes, checksum: 2d4939ef2f883a155737695a2e7c759a (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2016-03-09T15:22:37Z (GMT) No. of bitstreams: 1 2013_dis_cdpinheir

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19

Santos, Ana Rita Faria dos. "CD5, a molecular switch regulating signaling at the surface of T cells." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13747.

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Mestrado em Biologia Molecular e Celular<br>T cell receptor recognition of peptide-MHC expressed on antigen presenting cells (APC) involves the formation of a tight cell-cell contact area, named immunological synapse. Upon successful T cell activation, several signal transduction pathways are triggered culminating with the induction of gene transcription. The T cell surface glycoprotein CD5, an inhibitor of TCR signaling, is one of the molecules that targets to the immunological synapse upon T cell activation, although no ligand in the APCs has yet been discovered. We have determined that

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20

Nguyen, Khac Florence. "Etude clinique, cytologique, immunophénotypique de 12 cas de leucémie lymphoïde chronique B CD5." Paris 7, 1993. http://www.theses.fr/1993PA072099.

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21

Trenado-Bauquet, Aurélie. "Utilisation des propriétés immunosuppressives des lymphocytes T CD4+CD5+ dans l' alloréactivité pour contrôler la maladie du greffon contre l' hôte (GVH)." Paris 6, 2005. http://www.theses.fr/2005PA066254.

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22

Tabbekh, Mouna. "Rôle de CD5 dans la potentialisation de la réponse T cytotoxique et dans le contrôle de la progression tumorale dans un modèle in vivo." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T026.

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Un des défis majeurs de l’immunologie antitumorale repose sur l’induction efficace et prolongée de laphase effectrice de la réponse immune antitumorale. Une meilleure compréhension des mécanismesimpliqués dans la potentialisation de l’activité antitumorale des effecteurs immunitaires, en particulier lesCTL infiltrant la tumeur représente donc un enjeu considérable dans le développement de nouvellesapproches d’immunothérapie visant à induire une réponse immunitaire spécifique efficace contre latumeur. Dans ce contexte, nous nous sommes particulièrement intéressés à étudier le rôle de CD5 dans l

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23

Freitas, Claudia Mercedes. "Regulation of Immune Cell Activation and Functionby the nBMPp2 Protein andthe CD5 Co-Receptor." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8257.

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According to the centers for disease control and prevention (CDC) and the world healthorganization (WHO), heart disease and immune related diseases such as diabetes and cancer areamong the leading causes of death around the world. Thus, the regulation of the function ofimmune cell plays a key role in health and disease. Calcium (Ca2+) ions play a critical role inimmune cell activation, function and in a robust immune response. Defects in Ca2+ signalinginfluences the development of cardiac disease, Alzheimer disease, immune cell metabolism,muscle dysfunction, and cancer. Each immune cell is uni

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24

Grünewald, Thomas. "CD5+-B-Lymphozyten und Immunglobulin-Leichtketten bei HIV-Infizierten Korrelation mit klinischen und immunologischen Parametern /." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/282/index.html.

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25

Sainz, Perez Alexander. "Rôle de MDA-7/IL-24 dans les cellules B CD5+ de leucémie lymphoïde chronique." Paris 11, 2007. http://www.theses.fr/2007PA11T048.

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26

Przekopowitz, Martina [Verfasser], and Ralf [Akademischer Betreuer] Küppers. "Humane, reife CD5+ B-Zellen entsprechen murinen B-1a-Zellen / Martina Przekopowitz ; Betreuer: Ralf Küppers." Duisburg, 2017. http://d-nb.info/1125371277/34.

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27

Gagnon, Julien. "Les effets synergiques des cytokines pro-inflammatoires et des cytokines impliquées dans l’homéostasie sur les réponses des lymphocytes T CD8 aux antigènes." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8777.

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Résumé : L’IL-7 et l’IL-15 sont des cytokines impliquées dans l’homéostasie des lymphocytes T CD8 naïfs et mémoires respectivement. Lors d’une réponse immunitaire, certaines cytokines pro-inflammatoires, comme l’IL-6 et l’IL-21, sont produites par les cellules du système immunitaire inné. Nous avons observé que certaines cytokines de ces deux groupes (homéostasie et pro-inflammatoires), peuvent avoir un effet synergique sur la fonction des lymphocytes T CD8. Spécifiquement, l’incubation des lymphocytes T CD8 naïfs avec l’IL-6 ou l’IL-21, en présence d’IL-7 ou d’IL-15 cause une forte proliférat

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28

Blaize, Gaëtan. "Analyses moléculaire, cellulaire et fonctionnelle des protéines de signalisation CD5 et Themis1 dans les lymphocytes T." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30124.

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Les lymphocytes T (LT) sont des cellules essentielles du système immunitaire. Elles expriment à leur surface un récepteur, le TCR, qui a la capacité de reconnaître des peptides issus de la dégradation de protéines provenant d'agent infectieux associés aux molécules du complexe majeur d'histocompatibilité. Cette reconnaissance conduit à l'activation de signaux intracellulaires dans les LT propagés grâce à la coordination fine de molécules de signalisations cytosoliques ou membranaires qui agissent de concert pour entraîner des réponses cellulaires adaptées au type d'agent infectieux et permettr

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29

Weber, Jean-Christophe. "Lymphome b cd5 au cours de l'evolution d'un syndrome de gougerot sjogren primitif : etude clinique et analyse moleculaire." Université Louis Pasteur (Strasbourg) (1971-2008), 1990. http://www.theses.fr/1990STR1M188.

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30

Homp, Ekaterina [Verfasser], and Marc [Akademischer Betreuer] Seifert. "Funktionelle Analyse humaner reifer CD5+ B-Zellen aus Nabelschnurblut und adultem peripherem Blut / Ekaterina Homp ; Betreuer: Marc Seifert." Duisburg, 2021. http://d-nb.info/1238016715/34.

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31

Cheng, Gordon W. "Functions of CD45 in TCR signaling in CD4§+CD8§+ double-positive thymocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29256.pdf.

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32

Arévalo, Suárez Fernando, Sabino Portugal, Carlos Barreda, et al. "Enfermedad celíaca vs. atrofia villositaria serológicamente negativa: similitudes y diferencias histológicas y en el perfil inmunohistoquímico de linfocitos CD3, CD4, CD8 y CD56." Sociedad de Gastroenterología del Perú (SGP), 2016. http://hdl.handle.net/10757/617280.

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Existe un grupo de enteropatía conocidas como AVSN que pueden simular enfermedad celíaca. Objetivo: El objetivo de este estudio es describir los hallazgos histológicos y de inmunohistoquímica en pacientes con enfermedad celíaca y AVSN. Material y métodos: 15 biopsias de pacientes con enfermedad celíaca y 19 biopsias con AVSN fueron reexaminados. Se estudió características histológicas tales como atrofia severa, hiperplasia de criptas, número de células plasmáticas, número de eosinófilos y presencia de neutrófilos. Asimismo, a través de inmunohistoquímica se estudió la presencia de linfocitos C

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33

Harriague-Lhuillier, Julie. "Étude de l'activation de la PI3-kinase à la synapse immunologique et du rôle régulateur des molécules CD2 et CD5 dans la signalisation des récepteurs T et B pour l'antigène." Paris 7, 2002. http://www.theses.fr/2002PA077096.

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34

Garza-Garcia, Alicia Acely. "Production of disulphide-bonded domains suitable for NMR structure determination : application to the SRCR domains of the lymphocyte receptor CD5." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444414/.

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This work describes the development of a systematic methodology to overcome two of the difficulties commonly encountered when expressing eukaryotic domains in bacterial hosts, namely the failure to obtain folded protein in vivo and the low solubility of the expression product. This methodology made possible the production of samples of the first scavenger receptor cysteine rich (SRCR) domain of human CD5, /zCD5dl, with properties suitable for multidimensional NMR studies. The SRCR domains of /zCD5 express in bacteria as insoluble aggregates. The aggregates were purified in order to perform the

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35

Tueller, Josephine Anna. "Investigation of Therapeutic Immune Cell Metabolism." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8704.

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This thesis addresses multiple approaches to investigating mechanisms of immune linked disease. There are four projects outlined below which describe the work of these investigations. First, educating students about techniques to study disease and therapies is an important area of research. Flow cytometry is a common technique in immunology and its versatility and high throughput abilities can be applied to many fields. While it is very useful, flow cytometry is a complex technique that requires training to operate and understand, and there are very few reports about administering effective

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Othman, Abdulrazzag Abdulaziz. "The Use of Antibody-Coated Latex Beads To DetermineSingle Positive and Double Positive Mouse Spleen Cells Expressing CD5 and/orCD19 Glycoproteins." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1429579987.

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37

Suzuki-Jaecks, Ivy. "Fas ligand-mediated costimulation in peripheral T lymphocytes /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8319.

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38

Niu, Suli. "Quantitative Determination of Surface Markers on B-cell Chronic Lymphocytic Leukemia (CLL) Cells." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30982.

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To supplement and modify the diagnosis and clinical research of B-cell Chronic Lymphocytic Leukemia (B-CLL), a new method based on cell imaging and image processing was developed and applied to the B-CLL patient samples. The fluorophore-labelled leukemia cells were clearly visualized, reflecting the positive/negative expression of the corresponding surface markers and their distribution. Computer algorithms were devised and used to analyze a large number of images. The fluorescence intensity of the labelled antibodies on a given cell directly reflects the expression of the corresponding surfac

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Sultanik, Philippe-Simon. "Biomarqueurs de réponse à la trithérapie de 1ère génération dans l'hépatite C chronique." Paris 7, 2014. http://www.theses.fr/2014PA077257.

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L'infection chronique par le VHC est une maladie de santé publique qui touche près de 170 millions d'individus dans le monde. Jusqu'à aujourd'hui, il n'a pas été rapporté de marqueur biologique prédictif valide de réponse virologique à la trithérapie de première génération (interféron-pégylé/ribavirine/inhibiteur de protéase NS3) qui est le traitement actuel standard. L'immunité face au VHC comprend essentiellement l'immunité innée avec les interférons de type 1 et 3, et l'immunité cellulaire avec les LT spécifiques du VHC. Le sujet de ma thèse est de déterminer s'il existe des biomarqueurs as

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40

Haas, Karen Marie. "Induction and regulation of bovine B lymphocyte responses /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999290.

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41

Piccoli, Amanda Kirchner. "Expressão de proteínas reguladoras do complemento CD55/CD59/CD35/CD46 em pacientes com artrite reumatóide." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/28210.

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A Artrite Reumatóide (AR) é uma doença autoimune associada a poliartropatia inflamatória que acomete principalmente as articulações periféricas. Cerca de 1% da população mundial é afetada, sendo duas a três vezes mais prevalente em mulheres. Apresenta uma patogênese complexa e multifatorial. A sinóvia das articulações afetadas é infiltrada por linfócitos T e B, macrófagos e granulócitos. A sinóvia reumatóide adquire características proliferativas, formando o pannus, e invade a cartilagem articular e o osso, levando à destruição da arquitetura normal da articulação e perda de função. Em vários

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42

Julià, Manresa Marc. "Receptores del sistema inmunitario innato (Toll-like receptors y receptores de la Fc-gamma) y adaptativo (CD5 y CD6) como factores de susceptibilidad, modificadores de la enfermedad y respuesta al tratamiento biológico en psoriasis." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668023.

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La psoriasis es una enfermedad inflamatoria crónica inmunomediada principalmente cutánea caracterizada por la presencia de placas eritematodescamativas en zonas de extensión y cuero cabelludo. En su fisiopatogenia se implican múltiples componentes tanto al sistema inmunitario innato como adaptativo. En esta Tesis Doctoral, se presentan 4 trabajos originales en los que se analiza el impacto de distintos polimorfismos genéticos de receptores del sistema inmunitario innato (receptores toll-like y de la Fc-gamma) y de sistema inmunitario adaptativo (CD5 y CD6) como factores modificadores del fenot

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Anand, Arthi. "Characterization of CD3+CD4-CD8- (double negative) T cells in patients with systematic lupus erythematosus (SLE)." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1445261/.

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Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized serologically by B cell hyperactivity and a panoply of autoantibodies against nuclear, cytoplasmic and cell surface antigens. It is thought that T cells are involved in this process and more recently it has been suggested that the CD4+ CD8+, i.e.double negative (DN) T cells, might be important. As a start to understanding the contribution of DN T cells to disease pathogenesis in SLE, the percentages of DN T cells were determined and it was found that otp but not y5 DNT cells were significantly increased in pati

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Amrouche, Kahina. "Contrôle de la fonction régulatrice des lymphocytes B : effet du Glatiramer Acetate." Thesis, Brest, 2015. http://www.theses.fr/2015BRES0091/document.

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Le lymphocyte B (LB) des patients lupiques est réfractaire à tous les procédés décrits à ce jour pour activer une fonction régulatrice B (Breg). Il constitue de ce fait un modèle intéressant d’étude de la déficience Breg chez l’Homme et soulève de nombreuses interrogations. Est-il possible de restaurer un défaut d’activation de la régulation LB? Si oui est-il possible d'agir à temps et le plus efficacement possible, et comment s'y prendre? Ou au contraire, est-ce un état irréversible de la cellule B? Ce travail de thèse a pour objectif principal de répondre à cette problématique essentielle à

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Nishioka, Tomohisa. "CD4[+]CD25[+]Foxp3[+] T cells and CD4[+]CD25[-]Foxp3[+] T cells in aged mice." Kyoto University, 2007. http://hdl.handle.net/2433/135647.

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Fernandes, Camila. "Aumento da frequÃncia de cÃlulas T regulatÃrias CD4+CD25+FOXP3high E CD8+CD25+FOXP3high em pacientes menores de 15 anos com hansenÃase multibacilar." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9720.

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Universidade Federal do CearÃ<br>A hansenÃase Ã uma doenÃa crÃnica causada pelo Mycobacterium leprae, que representa um importante problema de saÃde pÃblica mundial, especialmente no estado do CearÃ, Brasil. A incidÃncia nos menores de 15 anos de idade reflete a endemicidade da regiÃo e a dificuldade no seu controle. A doenÃa apresenta um espectro variado de manifestaÃÃes clÃnicas que estÃ relacionado a resposta imune desenvolvida pelo indivÃduo, com as respostas Th1 e Th2 relacionadas com as formas paucibacilar e multibacilar, respecti

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Fernandes, Camila. "Aumento da frequência de células T regulatórias CD4+CD25+FOXP3high E CD8+CD25+FOXP3high em pacientes menores de 15 anos com hanseníase multibacilar." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/4824.

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FERNANDES, Camila. Aumento da frequência de células T regulatórias CD4+ CD25+ FOXP3 high e com CD8+ CD25+ FOXP3high em pacientes menores de 15 anos com hanseníase multibacilar. 2013. 92 f. Dissertação (Mestrado em Microbiologia Médica ) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2013.<br>Submitted by denise santos (denise.santos@ufc.br) on 2013-05-17T15:36:30Z No. of bitstreams: 1 2013_dis_cfernandes.pdf: 2771950 bytes, checksum: 5cdf0fffe2babc36cf1e1e546cb73d99 (MD5)<br>Approved for entry into archive by Erika Fernandes(erikaleitefernandes@gmail.com) on 2013-05-20T12:4

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Dal, Ben Ester Rosári Raphaelli. "Perfil de células T CD4+CD25+FoxP3+ e células B CD3-CD19+ em pacientes com síndrome antifosfolipídica primária e secundária." Pontifícia Universidade Católica do Rio Grande do Sul, 2013. http://hdl.handle.net/10923/4620.

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Made available in DSpace on 2013-08-07T19:06:05Z (GMT). No. of bitstreams: 1 000449049-Texto+Completo-0.pdf: 4601361 bytes, checksum: 2276ab000b49804c39de92d4bc7fd4ec (MD5) Previous issue date: 2013<br>Introduction: Antiphospholipid syndrome (APS) is characterized by venous or arterial thromboses, fetal losses and thrombocytopenia, in the presence of antiphospholipid antibodies (aPL). CD4+CD25+Foxp3+ regulatory T (Treg) cell dysfunction has been documented in various autoimmune disorders, but not in antiphospholipid syndrome (APS) up to date. Methods: In this cross-sectional study, we aim to

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Phothirath, Phoukham. "Génération de cellules T CD4+CD25+ suppressives induite par des lymphocytes T CD8+CD28- au cours de réactions leucocytaires mixtes autologues." Lyon 1, 2002. http://www.theses.fr/2002LYO1T195.

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La 4ème de couverture indique : "La réaction mixte lymphocytaire autologue (aMLR) permet l'étude des circuits de régulation du système immunitaire et correspond à la prolifération des lymphocytes T CD4+ suite à une stimulation par des cellules dendritiques autologues (aMLRs déficientes dans: maladie de Hodgkin, syndrome de Down, lupus érythémateux systématique, arthrite rhumatoi͏̈de, cirrhose biliaire primitive, etc). Les lymphocytes T CD8+CD28- sont des cellules régulatrices capables de suppression directe de l'allo- et la xéno-réactivité de lymphocytes T CD4+ et de rendre tolérogènes des cel

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Haas, Karen M. "Induction and regulation of bovine B lymphocyte responses." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999290.

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