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Journal articles on the topic 'CD5'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Semchenkova, Alexandra, Ekaterina Mikhailova, Irina Demina, et al. "Analysis of Antigen Expression in T-Cell Acute Lymphoblastic Leukemia by Multicolor Flow Cytometry: Implications for the Detection of Measurable Residual Disease." International Journal of Molecular Sciences 26, no. 5 (2025): 2002. https://doi.org/10.3390/ijms26052002.

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Multicolor flow cytometry (MFC) is a key method for assessing measurable residual disease (MRD) in acute lymphoblastic leukemia (ALL). However, very few approaches were developed for MRD in T-cell ALL (T-ALL). To identify MRD markers suitable for T-ALL, we analyzed the expression of CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD34, CD45, CD48, CD56, CD99, and HLA-DR in T-ALL patients at diagnosis. The median fluorescence intensities (MFIs) of surface CD3, CD4, CD5, CD7, CD8, CD45, CD48, CD99, and CD16+CD56 were also evaluated at Day 15 and the end-of-induction (EOI). The MFC data from 198 pediatric T-

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Escribano, Luis, Alberto Orfao, Jesús Villarrubia, et al. "Immunophenotypic Characterization of Human Bone Marrow Mast Cells. A Flow Cytometric Study of Normal and Pathological Bone Marrow Samples." Analytical Cellular Pathology 16, no. 3 (1998): 151–59. http://dx.doi.org/10.1155/1998/341340.

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The goal of the present paper was to define the immunophenotype of bone marrow mast cells (BMMC) from healthy controls and patients with hematologic malignancies (HM) based on the use of multiple stainings with monoclonal antibodies analyzed by flow cytometry. Our results show that BMMC from both groups of individuals display a similar but heterogenous immunophenotype. The overall numbers of BMMC are higher in the HM group of individuals (p= 0.08). Three patterns of antigen expression were detected: (1) markers constantly positive in all cases analyzed (CD9, CD29, CD33, CD43, CD44, CD49d, CD49

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3

Abbott, Daniel, Steven Kroft, Maria Hintzke, et al. "Immunophenotypic Analysis of Peripheral T-Cell Lymphomas: A Single-Center Retrospective Review of Flow Cytometric Analysis." American Journal of Clinical Pathology 152, Supplement_1 (2019): S109. http://dx.doi.org/10.1093/ajcp/aqz121.012.

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Abstract Background Peripheral T-cell lymphomas (PTCLs) are heterogenous, mature T-cell neoplasms that are a diagnostic challenge, requiring a combination of morphologic assessment and ancillary studies. Flow cytometry (FC) is a tool used routinely in lymphoma diagnosis; however, most analyses are limited to B-cell evaluation and pathologists generally lack experience evaluating for PTCL. We aimed to describe the immunophenotypic aberrancies observed by FC in PTCL. Design PTCLs with FC were collected, excluding primary leukemic processes. Four- and eight-color FC data were reanalyzed with the

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Зыблева, С. В., and С. Л. Зыблев. "Cluster Analysis of Leukocyte Subpopulations in Kidney Transplantation." Гематология. Трансфузиология. Восточная Европа, no. 2 (November 8, 2021): 168–75. http://dx.doi.org/10.34883/pi.2021.7.2.005.

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Цель. Выявить варианты иммунного реагирования у пациентов при трансплантации почки на основе кластерного анализа, характеризующие течение посттрансплантационного периода. Материалы и методы. Обследовано 104 реципиента почечного трансплантата с терминальной стадией хронической болезни почек, которым выполнена трансплантация аллогенной почки, а также 90 здоровых добровольцев, составивших группу сравнения. Оценены уровни лейкоцитов с использованием метода проточной цитометрии по безотмывочной технологии с использованием моноклональных антител (Beckman Coulter и BD, США) CD4 PС7, CD8 FITC, CD3 PС5

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Rasmussen, R. A., S. L. Counts, J. F. Daley, and S. F. Schlossman. "Isolation and characterization of CD6- T cells from peripheral blood." Journal of Immunology 152, no. 2 (1994): 527–36. http://dx.doi.org/10.4049/jimmunol.152.2.527.

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Abstract Antibodies to the CD6 Ag have been described as having pan-T cell reactivity. We have recently demonstrated, however, that after treatment of PBL with an anti-CD6-blocked ricin-conjugated immunotoxin, clonal populations of CD3+, CD6- cells can be identified. Herein we show that through dual parameter staining of freshly isolated E-rosette+ cells, an average of 5 to 6% of either CD3+ or CD5+ cells express little or no CD6 on their surface. After negative selection by antibody-coated paramagnetic bead depletion, expanded CD6- T cells were shown to be CD1a-, CD2+, CD3+, CD5+, CD16-, CD56

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6

Carmo, Alexandre M., Mónica A. A. Castro, and Fernando A. Arosa. "CD2 and CD3 Associate Independently with CD5 and Differentially Regulate Signaling Through CD5 in Jurkat T Cells." Journal of Immunology 163, no. 8 (1999): 4238–45. http://dx.doi.org/10.4049/jimmunol.163.8.4238.

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Abstract In T lymphocytes, the CD2 and CD5 glycoproteins are believed to be involved in the regulation of signals elicited by the TCR/CD3 complex. Here we show that CD2 and CD3 independently associate with CD5 in human PBMC and Jurkat cells. CD5 coprecipitates with CD2 in CD3-deficient cells and, conversely, coprecipitates with CD3 in cells devoid of CD2. In unstimulated CD2+ CD3+ Jurkat cells, CD5 associates equivalently with CD2 and CD3 and is as efficiently phosphorylated in CD2 as in CD3 immune complexes. However, upon activation the involvement of CD5 is the opposite in the CD2 and CD3 pa

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7

Chatila, T. A., and R. S. Geha. "Phosphorylation of T cell membrane proteins by activators of protein kinase C." Journal of Immunology 140, no. 12 (1988): 4308–14. http://dx.doi.org/10.4049/jimmunol.140.12.4308.

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Abstract Activation of the enzyme protein kinase C (PKC) plays an important role in T cell activation. We investigated the phosphorylation of CD2, CD3, CD4, CD5, CD7, CD8, CD28 (Tp44), CD43 (sialophorin, gp115), and LFA-1 after incubation of human PBMC with the (PKC) activator PMA. These proteins were chosen for their role in transmembrane signal transduction (CD2, CD3, CD5, CD28, CD43), cell-cell interaction and adhesion (CD2, CD4, CD8, and LFA-1), or involvement in immunodeficiency states (CD43, CD7). CD5, CD7, CD43, and the alpha-chain of LFA-1 were found to be constitutively phosphorylated

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8

Sánchez, M. J., H. Spits, L. L. Lanier, and J. H. Phillips. "Human natural killer cell committed thymocytes and their relation to the T cell lineage." Journal of Experimental Medicine 178, no. 6 (1993): 1857–66. http://dx.doi.org/10.1084/jem.178.6.1857.

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Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells and T cells under appropriate conditions. In the present study, we have investigated human fetal and postnatal thymus to determine whether NK cells and their precursors exist within this tissue and whether NK cells can be distinguished from T cell progenitors. Based on the surface expression of CD56 (an NK cell-associated antigen) and CD5 (a T ce

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9

Shaheen, M., L. Warmke, and M. Nassiri. "Focal Myositis with CD8+T-Cell predominance: an Inflammatory Myositis Mimicking a Soft Tissue Neoplasm." American Journal of Clinical Pathology 158, Supplement_1 (2022): S109. http://dx.doi.org/10.1093/ajcp/aqac126.231.

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Abstract Introduction/Objective FM is a rare self-limiting T-cell rich lesion arising within muscles of young adults as a solitary lesion and can be confused with a variety of neoplastic/inflammatory conditions or lymphoma. Here we describe a rare T-cell rich variant of FM with CD8 predominance. Methods/Case Report A 51-year-old female presented with two-month history of left trapezius swelling. MRI showed an enhancing tumor within the muscle, suspicious of sarcoma, less likely myeloma. Results (if a Case Study enter NA) Biopsy showed diffuse infiltration of small lymphocytes in a fibrotic bac

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Safronova, E. A. "Dynamic features of the humoral immunity in patients with acute coronary syndrome depending on the content of B lymphocytes with the CD3<sup>-</sup>CD19<sup>+</sup>CD5<sup>+</sup> phenotype, who have and have not COVID-19." Russian Journal of Immunology 27, no. 2 (2024): 267–72. http://dx.doi.org/10.46235/1028-7221-16829-dfo.

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The purpose of the work was to study the dynamic features of the humoral immunity in patients with acute coronary syndrome depending on the content of B lymphocytes with the CD3-CD19+CD5+ phenotype, who had and did not have COVID-19. We analyzed data on humoral immunity in men aged 40 to 65 years with acute coronary syndrome, who had and did not have COVID-19, depending on the content of B lymphocytes with the CD3-CD19+CD5+ phenotype. All patients underwent coronary angiography with further stenting of the coronary arteries. The values of lymphocytes with the CD45+CD3-CD19+ phenotype and the p

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Laharwani, H., K. Perrizo, S. Jain, and J. Lam. "A Rare Case of Chronic Lymphoproliferative Disorder of NK Cells with an Unusual Expression of CD57." American Journal of Clinical Pathology 154, Supplement_1 (2020): S101. http://dx.doi.org/10.1093/ajcp/aqaa161.221.

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Abstract Introduction/Objective Natural Killer cells (NK-cells) malignancies are extremely rare and the two NK-cell disorders involving the peripheral blood and bone marrow include chronic lymphoproliferative disorder of NK-cells (CLPDNK) and aggressive NK-cell leukemia (ANKL). ANKL is EBV associated with a prevalence in Asian adults and a fulminant clinical course leading to death within 2 months. Methods A 76-year-old female with a history of iron deficiency anemia presented for evaluation of lymphocytosis (78 TH/mm) and negative EBV with extreme fatigue, weight loss, and worsening weakness

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12

Wang, Huan-You, Kathleen S. Wilson, Robert W. McKenna, Yin Xu, and Nitin Karandikar. "An Extranodal Nasal Natural Killer/T-Cell Lymphoma With Isochromosome 7q10 as the Sole Cytogenetic Aberration Was Initially Diagnosed Via Bone Marrow Biopsy." Archives of Pathology & Laboratory Medicine 131, no. 11 (2007): 1709–14. http://dx.doi.org/10.5858/2007-131-1709-aenntl.

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Abstract We report a 58-year-old man who presented with fever, pancytopenia, hepatosplenomegaly, and “sinusitis” of his right nostril. Flow cytometric analysis of his bone marrow aspirate revealed a population of cells that were CD56+ (bright), CD2+ (dim), and CD7+ (slight brightly) but negative for CD3, CD4, CD5, CD8, CD11b, CD16, CD57, and T-cell receptors, consistent with aberrant natural killer cells. Bone marrow biopsy showed an atypical lymphoid infiltrate expressing CD56 as well as Epstein-Barr virus– encoded RNA and histiocytic hyperplasia with hemophagocytosis. Subsequent biopsy of hi

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Dobrynina, Maria A., Aleksandr V. Zurochka, Mariia V. Komelkova, Vladimir A. Zurochka, and Alexey P. Sarapultsev. "Disturbances in the b cell component of immune system and associated immune alterations in post-covid patients." Russian Journal of Immunology 26, no. 3 (2023): 241–50. http://dx.doi.org/10.46235/1028-7221-9636-dit.

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There is only limited data on B-cell response in post-COVID patients despite its importance in studying the post-infection immunity. The present study aimed to investigate the features of the B-cell response in post-COVID patients, focusing on various B cell phenotypes. Along with the standard immunogram, the following cell phenotypes were examined: common B cells (CD45+, CD3-, CD19+); common memory cells (CD45+, CD3-, CD19+, CD27+); common non-memory cells (CD45+, CD3-, CD19+, CD5+); B1 memory cells (CD45+, CD3-, CD19+, CD5+, CD27+); B2 memory cells (CD45+, CD3-, CD19+, CD5-, CD27+); B1 non-m

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14

Zybleva, S. V., and S. L. Zyblev. "Immunological cluster complexes in kidney transplantation." Medical Immunology (Russia) 24, no. 1 (2022): 69–80. http://dx.doi.org/10.15789/1563-0625-icc-2212.

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Laboratory tests are significant for the detection of immunopathological disorders in kidney transplantation. As a rule, the choice of tests is carried out individually and is based on the clinical characteristics and the presumptive diagnosis. Most often, in patients after kidney transplantation, atypical and not always standard changes in immunological parameters are observed, which is associated with a combination of many factors leading to different immune responses. All this served as the basis for typing immunological parameters in renal allograft recipients using one of the methods of s

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15

Cro, Lilla, Andrea Ferrario, Nadia Zucal, et al. "Diagnostic Role of Flow Cytometry Analysis of Bioptical Samples in the Diagnosis of Lymphoid Tumors." Blood 112, no. 11 (2008): 5286. http://dx.doi.org/10.1182/blood.v112.11.5286.5286.

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Abstract We reviewed flow cytometric immunophenotyping (FCI) data of 470 tissue suspensions suspected of being involved by lymphoma (371 lymph nodes, 263 surgical biopsies and 108 fine needle aspirations,16 spleens, 6 tonsils, and 77 other tissues) and we have compared corresponding histologic diagnosis. The screening panel of FCI (CD45, CD19, CD3, CD4, CD8, and sIgκ/sIgλ ratio) identified three main groups: 239 cases with demonstrable light chain restriction (sIgκ/sIgλ ratio ≤ 0.5 or ≥4); 37 cases with demonstrable T cell proliferation and polyclonal B cell population; 194 cases with polyclon

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16

Savlevich, E. L., O. M. Kurbacheva, S. V. Khaidukov, A. N. Gerasimov, M. E. Amanturlieva, and A. S. Simbirtcev. "THE DIAGNOSTIC SIGNIFICANCE OF IMMUNOLOGICAL PARAMETERS OF THE PATIENTS WITH CHRONIC RHINOSINUSITIS WITH NASAL POLYPS." Russian Journal of Allergy 14, no. 4-5 (2017): 40–45. http://dx.doi.org/10.36691/rja293.

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Background. Investigation of changes in immunological parameters is required to detect the degree of adequate immune system reactions to pathology process and to determine the answer to provided treatment. Taking into account high immunogramm cost differentiated approach is necessary in each specific case basing on economic and diagnostic effectiveness. Now chronic rhinosinusitis with nasal polyps (CRSwNP) is still poorly investigated. In the same clinical situation it is difficult to predict the pathology process development and length of remission period after surgical or conservative treatm

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Brauner, Jonathan, Ingrid Beukinga, Zoulikha Amraoui, Zaina Kassengera, Michel Toungouz, and Olivier Pradier. "Flow Cytometry Primary 10 Colours Panel for Chronic Lympho Proliferative Diseases Diagnosis." Blood 118, no. 21 (2011): 5190. http://dx.doi.org/10.1182/blood.v118.21.5190.5190.

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Abstract Abstract 5190 Objectives: Definition of the primary antibodies panel for 10 colours flow cytometry able to describe normal and clonal T, B lymphocytes and plamocytes in blood and bone marrow. Once clonalities are detected, the complete characterisation of Chronic Lymphoproliferative Diseases (CLPD) is supported by secondary panels chosen based on the results of CD5/CD10 expression for clonal B lymphocytes, CD27/CD38 for plasmatocytes and CD3/CD27 for clonal T cells. Materials and Methods: Blood and bone marrow of patients (N=50) with CLPD (mainly B-CLL). Samples are enumerated by haem

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18

Terstappen, LW, S. Huang, and LJ Picker. "Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow." Blood 79, no. 3 (1992): 666–77. http://dx.doi.org/10.1182/blood.v79.3.666.bloodjournal793666.

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Using multidimensional flow cytometry we have defined and quantified the human T-cell differentiation pathway, focusing on those events occurring among the most immature thymocytes and putative bone marrow (BM) T-precursors. Early thymocytes were found to express the CD34 antigen and consisted of a mean 1.2% of cells within human pediatric (n = 9) and 2.0% in fetal thymi (n = 4). All CD34+ thymocytes were atypical blast by morphology, expressed intracytoplasmatic, but not cell surface, CD3, and were cell surface CD2+, CD5+, CD7+, CD38+, CD45+, CD45RA+, CD49d+, and LECAM-1(Leu8)high. CD34high t

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Raimondi, SC, FG Behm, PK Roberson, et al. "Cytogenetics of childhood T-cell leukemia." Blood 72, no. 5 (1988): 1560–66. http://dx.doi.org/10.1182/blood.v72.5.1560.1560.

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Abstract The karyotypes of 57 cases of childhood T-cell acute lymphoblastic leukemia (ALL) were analyzed to establish the cytogenetic profile in this disease. Three questions were of particular interest. Do the chromosomal changes in T-cell ALL preferentially affect bands where genes encoding the T-cell receptor for antigen (TCR) have been mapped? Do alterations involving the TCR gene regions appear with any notable frequency in B-progenitor ALL? Do chromosomal abnormalities in this disease relate to stage of T-cell ontogeny? A relatively high proportion of cases (65%) had a pseudodiploid kary

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Raimondi, SC, FG Behm, PK Roberson, et al. "Cytogenetics of childhood T-cell leukemia." Blood 72, no. 5 (1988): 1560–66. http://dx.doi.org/10.1182/blood.v72.5.1560.bloodjournal7251560.

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The karyotypes of 57 cases of childhood T-cell acute lymphoblastic leukemia (ALL) were analyzed to establish the cytogenetic profile in this disease. Three questions were of particular interest. Do the chromosomal changes in T-cell ALL preferentially affect bands where genes encoding the T-cell receptor for antigen (TCR) have been mapped? Do alterations involving the TCR gene regions appear with any notable frequency in B-progenitor ALL? Do chromosomal abnormalities in this disease relate to stage of T-cell ontogeny? A relatively high proportion of cases (65%) had a pseudodiploid karyotype at

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Safronova, E. A., and L. V. Ryabova. "Assessment of lymphocyte populations and their subsets in the patients with acute coronary syndrome." Russian Journal of Immunology 25, no. 3 (2022): 313–20. http://dx.doi.org/10.46235/1028-7221-1135-aol.

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We examined 23 patients aged 40 to 65 years (mean age 54.526.72) with a diagnosis of acute coronary syndrome (ACS) at admission, who underwent emergency or delayed coronary stenting a day later. All patients had arterial hypertension as a concomitant disease. Upon additional examination, blood troponin levels were determined, ECG was performed in the time dynamics. Acute myocardial infarction with ST elevation was diagnosed in 7 patients, infarction without ST elevation, in 6 patients, the unstable angina rest, in the rest of this group (Grace risk from 75 to 150 points, on average, 107.727.16

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Tsuchiyama, Junjiro, Tadashi Yoshino, Masaharu Mori, et al. "Characterization of a Novel Human Natural Killer-Cell Line (NK-YS) Established From Natural Killer Cell Lymphoma/Leukemia Associated With Epstein-Barr Virus Infection." Blood 92, no. 4 (1998): 1374–83. http://dx.doi.org/10.1182/blood.v92.4.1374.

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Abstract A novel cell line was established from a patient with a leukemic-state nasal angiocentric natural killer (NK) cell lymphoma with systemic skin infiltration. The morphology of the leukemic cells was large-granular-lymphocyte (LGL), and their immunophenotype was CD2+, CD3−, CD5+, CD7+, CD16−, CD56+, and CD57−. The presence of Epstein-Barr viral (EBV) genome was shown in specimens from the patient’s nose, skin, and peripheral blood by in situ hybridization using an EBV-encoded small RNA-1 probe or by Southern blotting using a terminal-repeat probe of the EBV genome. Leukemic cells were c

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Tsuchiyama, Junjiro, Tadashi Yoshino, Masaharu Mori, et al. "Characterization of a Novel Human Natural Killer-Cell Line (NK-YS) Established From Natural Killer Cell Lymphoma/Leukemia Associated With Epstein-Barr Virus Infection." Blood 92, no. 4 (1998): 1374–83. http://dx.doi.org/10.1182/blood.v92.4.1374.416a33_1374_1383.

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A novel cell line was established from a patient with a leukemic-state nasal angiocentric natural killer (NK) cell lymphoma with systemic skin infiltration. The morphology of the leukemic cells was large-granular-lymphocyte (LGL), and their immunophenotype was CD2+, CD3−, CD5+, CD7+, CD16−, CD56+, and CD57−. The presence of Epstein-Barr viral (EBV) genome was shown in specimens from the patient’s nose, skin, and peripheral blood by in situ hybridization using an EBV-encoded small RNA-1 probe or by Southern blotting using a terminal-repeat probe of the EBV genome. Leukemic cells were cocultured

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Yumura-Yagi, Keiko, Shigehiko Ishihara, Junichi Hara, et al. "Poor prognosis of mediastinal non-Hodgkin's lymphoma with an immature phenotype of CD2+, CD7 (or CD5)+, CD3−, CD4−, and CD8−." Cancer 63, no. 4 (1989): 671–74. http://dx.doi.org/10.1002/1097-0142(19890215)63:4<671::aid-cncr2820630413>3.0.co;2-x.

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Shi, Min, Phuong Nguyen, Michael M. Timm та ін. "Cytoplasmic Expression of CD3ε Heterodimers by Flow Cytometry Rapidly Distinguishes Between Mature T-Cell and Natural Killer–Cell Neoplasms". American Journal of Clinical Pathology 154, № 5 (2020): 683–91. http://dx.doi.org/10.1093/ajcp/aqaa086.

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Abstract Objectives Distinguishing between T-cell and natural killer (NK)–cell neoplasms could be difficult given their overlapping immunophenotype. In this study, we investigated whether a flow cytometry assay with cytoplasmic staining for CD3 could be used for this purpose. Methods Flow cytometry immunophenotyping was performed on 19 surface CD3 (sCD3)–negative mature T-cell neoplasms, 10 sCD3-positive mature T-cell neoplasms, 13 mature NK-cell neoplasms, and 19 normal controls. In addition to routine antibody panels (CD2, sCD3, CD4, CD5, CD7, CD8, CD16, CD45, CD56, CD57, CD94, CD158a, CD158

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Ivanova, I. A., A. V. Filippenko, N. V. Pavlovich, et al. "Immune status of patients with community-acquired pneumonia associated with a new coronavirus infection and other viral and bacterial pathogens." Russian Journal of Infection and Immunity 14, no. 2 (2024): 267–76. http://dx.doi.org/10.15789/2220-7619-iso-17589.

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Despite the fact that the state of the individual’s immune system plays an important role in developing community-acquired pneumonia, its clinical features are determined not only by immune response characteristics, but also by the nature of the infectious agent. The aim of the work was to assess immune status of patients with community-acquired pneumonia with lung damage ranging from 2 to 12%, in whom pathogens of a viral, bacterial and fungal nature were verified (n = 96, aged 46,3±20,5) who were admitted to the hospital 5–7 days after disease onset. Materials and methods. The selection of s

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Kalashnikova, A. A., and N. V. Bychkova. "Minor population of NK lymphocytes with CD19 coexpression." Medical Immunology (Russia) 26, no. 3 (2024): 513–22. http://dx.doi.org/10.15789/1563-0625-mpo-2920.

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Single reports were published concerning a minor subpopulation of NK cells with weak coexpression of the B cell antigen CD19 in the patients’ blood and bone marrow. The frequency and relative number of CD56+CD19+dim cells is virtually not assessed, and there is no data on their phenotypic characteristics, as well as the connection of this subpopulation with any disease state. The purpose of the present study was to assess the frequency, relative quantity and phenotypic characteristics of CD56+CD19+dim lymphocytes in blood of patients referred for assessment of the lymphocyte subpopulation prof

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Dogra, S., J. P. Mangipudy, E. Asatiani, et al. "Aberrant immunophenotype in acute myeloid leukemia (AML): High frequency and association with dysplasia." Journal of Clinical Oncology 25, no. 18_suppl (2007): 17504. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.17504.

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17504 Background: Asynchronous expression of immunophenotypic markers on AML myeloblasts has been well described, but the association of aberrant phenotype with morphologic subclasses has not been reported previously. Methods: Multiparameter flow cytometry (MFC) data were analyzed for all patients (pts) diagnosed with AML at our institution from 2000–2006. MFC was done on fresh bone marrow aspirate and/or peripheral blood samples using the following panel of monoclonal antibodies in triple staining: CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD22, CD24, CD33

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Pelegrı́, Carme, Jordi Vilaplana, Cristina Castellote, Manel Rabanal, Àngels Franch, and Margarida Castell. "Circadian rhythms in surface molecules of rat blood lymphocytes." American Journal of Physiology-Cell Physiology 284, no. 1 (2003): C67—C76. http://dx.doi.org/10.1152/ajpcell.00084.2002.

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The present article examines whether the expression of certain surface molecules that trigger immune responses shows a circadian rhythm. We also analyzed the rhythms in the number and percentage of lymphocyte subpopulations, in the leukocyte differential counts, and in the total red and white blood cell counts. Blood samples obtained from rats at 2-h intervals for 24 h were stained with several mouse monoclonal antibodies directed against lymphocyte surface molecules and processed by flow cytometry. The number of B, total T, Tγδ, Th, and Ts/c cells followed a 24-h rhythm with a peak in the fir

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Alberola-Ila, J., L. Places, F. Lozano, and J. Vives. "Association of an activation inducible serine kinase activity with CD5." Journal of Immunology 151, no. 9 (1993): 4423–30. http://dx.doi.org/10.4049/jimmunol.151.9.4423.

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Abstract We show the association of a protein kinase activity with CD5 immunoprecipitates under different detergent conditions (1% digitonin, 1% Triton X-100). This association can be observed in all CD5+ cell types tested (PBMC, thymocytes, B cells from chronic lymphocytic leukemia, and some lymphoblastoid T cell lines as Jurkat, Molt-4, 8402). Phosphoaminoacid analysis of the in vitro phosphorylated proteins and Western blot analysis of the immunoprecipitates with an antiphosphotyrosine mAb show that, in contrast with other lymphocyte receptors (CD3, CD4, IL-2R), CD5 coimmunoprecipitates a s

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Barcena, A., MO Muench, AH Galy, et al. "Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development." Blood 82, no. 11 (1993): 3401–14. http://dx.doi.org/10.1182/blood.v82.11.3401.3401.

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Abstract It has been proposed that the CD7 molecule is the first antigen expressed on the membrane of cells committed to the T-cell lineage during human fetal T-cell ontogeny. To further identify the pre-T cell subpopulation that migrates to the thymus early in ontogeny, we analyzed the phenotypic and functional characteristics of the fetal liver populations separated on the basis of CD7 expression. Three populations expressing different levels of CD7 were observed: CD7bright, CD7dull, and CD7-. A CD7bright population depleted of mature T, B, and myeloid cells (lineage negative, lin-) and most

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Barcena, A., MO Muench, AH Galy, et al. "Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development." Blood 82, no. 11 (1993): 3401–14. http://dx.doi.org/10.1182/blood.v82.11.3401.bloodjournal82113401.

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It has been proposed that the CD7 molecule is the first antigen expressed on the membrane of cells committed to the T-cell lineage during human fetal T-cell ontogeny. To further identify the pre-T cell subpopulation that migrates to the thymus early in ontogeny, we analyzed the phenotypic and functional characteristics of the fetal liver populations separated on the basis of CD7 expression. Three populations expressing different levels of CD7 were observed: CD7bright, CD7dull, and CD7-. A CD7bright population depleted of mature T, B, and myeloid cells (lineage negative, lin-) and mostly compos

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Araujo, Maria das Graças Pereira, Victor lima Soares, Alessandra Suelen Jardim Silva, et al. "Importance of Flow Cytometry in the Diagnosis of Sezary Syndrome in the State of Rio Grande Do Norte, Brazil." Blood 136, Supplement 1 (2020): 39–40. http://dx.doi.org/10.1182/blood-2020-143378.

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Introduction:Sézary Syndrome (SS) is a leukemic form of Fungal Mycosis (FM), a rare form of T-cell lymphoma, characterized by erythroderma, generalized lymphadenopathy and infiltration of neoplastic T cells (Sézary cells) with cerebriform nucleus on the skin, lymph nodes and peripheral blood, being observed predominantly in men and individuals over the age of 60 and black. In the diagnosis of SS / FM, at least one of the criteria must be observed: minimum absolute Sézary cells count of 1000/mm3, expansion of TCD4+ cells with a ratio CD4/CD8 &gt;10, loss of at least one mature T cell antige

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Biancone, L., M. A. Bowen, A. Lim, A. Aruffo, G. Andres, and I. Stamenkovic. "Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes." Journal of Experimental Medicine 184, no. 3 (1996): 811–19. http://dx.doi.org/10.1084/jem.184.3.811.

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CD5 is a 67-kD glycoprotein that is expressed on most T lymphocytes and on a subset of mature B cells. Although its physiologic function is unknown, several lines of evidence suggest that CD5 may play a role in the regulation of T cell activation and in T cell-antigen presenting cell interactions. Using a CD5-immunoglobulin fusion protein (CD5Rg, for receptorglobulin) we have uncovered a new CD5 ligand (CD5L) expressed on the surface of activated splenocytes. Stimulation of murine splenocytes with anti-CD3 and anti-CD28 antibodies induce transient expression of CD5L on B lymphocytes that lasts

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Филиппова, О. Е., Л. С. Щёголева, Т. Б. Сергеева, Е. Ю. Шашкова, Е. В. Поповская та М. С. Каббани. "СООТНОШЕНИЕ ЛИМФОПРОЛИФЕРАТИВНОЙ АКТИВНОСТИ И АПОПТОЗА У ЛИЦ ПРИ ЧЕРЕПНО-МОЗГОВОЙ ТРАВМЕ". NOVYE ISSLEDOVANIA 60, № 2 (2022): 44–51. http://dx.doi.org/10.46742/2072-8840-2022-70-2-44-51.

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Реализация комплексного иммунологического исследования пострадавших с ЧМТ в первые сутки с момента её получения позволяет прогнозировать варианты течения заболевания и осложнений. Обследовано 89 мужчин 20-40 лет с ЧМТ и изучено содержание в периферической крови фенотипов лимфоцитов CD3+, CD4+, CD5+, CD8+, CD10+, CD16+, CD25+, CD71+, HLA-DR+, CD95+. У пострадавших уровень лимфопролиферации CD10+ снижается с возрастанием степени тяжести травмы, обратно пропорционален активности апоптоза CD95+ и клеточно-опосредованной цитотоксичности (CD8+) на фоне выраженного дефицита Т-клеточной популяции CD5+

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Muzzafar, Tariq, Eric X. Wei, Pei Lin, L. Jeffrey Medeiros, and Jeffrey L. Jorgensen. "Flow Cytometric Immunophenotyping of Anaplastic Large Cell Lymphoma." Archives of Pathology & Laboratory Medicine 133, no. 1 (2009): 49–56. http://dx.doi.org/10.5858/133.1.49.

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Abstract Context.—Anaplastic large cell lymphoma (ALCL) is usually diagnosed by histologic and immunohistochemical analysis. However, fine-needle aspiration is becoming a popular alternative to lymph node biopsy, and flow-cytometric immunophenotyping is often used to analyze fine-needle aspiration specimens. Objective.—To review our experience using flow-cytometric immunophenotyping to assess cases of ALCL and to evaluate the diagnostic utility of this technique. Design.—Each case of ALCL was assessed by flow cytometry with 3-color or 4-color antibody panels, and data were reanalyzed by cluste

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Gorczyca, Wojciech, and Henry Y. Dong. "Subset of T-Cell Prolymphocytic Leukemia Expresses CD117. Potential Target for Therapy." Blood 104, no. 11 (2004): 4540. http://dx.doi.org/10.1182/blood.v104.11.4540.4540.

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Abstract Introduction Excluding non-hematopoietic lesions, CD117 (c-kit) is expressed by erythroid, megakaryocytic and myeloid precursors, mature mast cells, subset of plasma cell neoplasm and occasional precursor lymphoblastic tumors. C-kit plays important role in T-cell development around birth, but the expression of CD117 in mature T-cell lymphoproliferations is rare. We present flow cytometry phenotypic data of 28 cases of T-cell prolymphocytic leukemia (T-PLL). Material and methods Multiparameter 4-color FC analysis was performed on peripheral blood and/or bone marrow aspirate samples usi

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Raab, M., M. Yamamoto, and C. E. Rudd. "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck." Molecular and Cellular Biology 14, no. 5 (1994): 2862–70. http://dx.doi.org/10.1128/mcb.14.5.2862-2870.1994.

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CD5 is a T-cell-specific antigen which binds to the B-cell antigen CD72 and acts as a coreceptor in the stimulation of T-cell growth. CD5 associates with the T-cell receptor zeta chain (TcR zeta)/CD3 complex and is rapidly phosphosphorylated on tyrosine residues as a result of TcR zeta/CD3 ligation. However, despite this, the mechanism by which CD5 generates intracellular signals is unclear. In this study, we demonstrate that CD5 is coupled to the protein-tyrosine kinase p56lck and can act as a substrate for p56lck. Coexpression of CD5 with p56lck in the baculovirus expression system resulted

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Raab, M., M. Yamamoto, and C. E. Rudd. "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck." Molecular and Cellular Biology 14, no. 5 (1994): 2862–70. http://dx.doi.org/10.1128/mcb.14.5.2862.

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CD5 is a T-cell-specific antigen which binds to the B-cell antigen CD72 and acts as a coreceptor in the stimulation of T-cell growth. CD5 associates with the T-cell receptor zeta chain (TcR zeta)/CD3 complex and is rapidly phosphosphorylated on tyrosine residues as a result of TcR zeta/CD3 ligation. However, despite this, the mechanism by which CD5 generates intracellular signals is unclear. In this study, we demonstrate that CD5 is coupled to the protein-tyrosine kinase p56lck and can act as a substrate for p56lck. Coexpression of CD5 with p56lck in the baculovirus expression system resulted

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Dutz, J. P., C. J. Ong, J. Marth, and H. S. Teh. "Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection." Journal of Immunology 154, no. 6 (1995): 2588–99. http://dx.doi.org/10.4049/jimmunol.154.6.2588.

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Abstract Cortical CD4+CD8+ thymocytes mature into CD4+ or CD8+ thymocytes through a process termed positive selection. To better define differentiative stages of CD4+CD8+ thymocyte development in positive selection, we performed a phenotypic analysis of CD4+CD8+ thymocytes from H-Y mice mated to various genetic backgrounds. We have previously shown that coordinate binding of the H-Y TCR and the CD8 coreceptor to the restricting Db MHC class I molecule is required for the efficient positive selection of this TCR. In this study we have used TCR, CD5, and CD45 expression levels as markers for thy

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Terstappen, LW, S. Huang, and LJ Picker. "Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow." Blood 79, no. 3 (1992): 666–77. http://dx.doi.org/10.1182/blood.v79.3.666.666.

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Abstract Using multidimensional flow cytometry we have defined and quantified the human T-cell differentiation pathway, focusing on those events occurring among the most immature thymocytes and putative bone marrow (BM) T-precursors. Early thymocytes were found to express the CD34 antigen and consisted of a mean 1.2% of cells within human pediatric (n = 9) and 2.0% in fetal thymi (n = 4). All CD34+ thymocytes were atypical blast by morphology, expressed intracytoplasmatic, but not cell surface, CD3, and were cell surface CD2+, CD5+, CD7+, CD38+, CD45+, CD45RA+, CD49d+, and LECAM-1(Leu8)high. C

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Damle, N. K., and L. V. Doyle. "Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4+CD29+CD45R- memory T lymphocytes." Journal of Immunology 143, no. 6 (1989): 1761–67. http://dx.doi.org/10.4049/jimmunol.143.6.1761.

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Abstract Although both IL-2 and IL-4 can promote the growth of activated T cells, IL-4 appears to selectively promote the growth of those helper/inducer and cytolytic T cells which have been activated via their CD3/TCR complex. The present study examines the participation of CD28 and certain other T cell-surface molecules in inducing T cell responsiveness to IL-4. Purified small high density T cells were cultured in the absence of accessory cells with various soluble anti-human T cell mAb with or without soluble anti-CD3 mAb and their responsiveness to IL-4 was studied. None of the soluble ant

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Singh, Anju, Anne Flörcken, Antje van Lessen, Bernd Dörken, Antonio Pezzutto, and Jörg Westermann. "CD3-Negative CD4+ T-Cells: A Useful Diagnostic Tool with High Specificity in Angioimmunoblastic Lymphadenopathy (AILD)-Type T-Cell Lymphoma." Blood 112, no. 11 (2008): 5311. http://dx.doi.org/10.1182/blood.v112.11.5311.5311.

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Abstract Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma is one of the common T cell lymphomas in Western countries. Many patients present with symptoms of a systemic disease and diagnosis can often be challenging. Particularly in cases in which histological confirmation cannot be easily achieved flowcytometry of peripheral blood can give important clues for the differential diagnosis of AILD. We have previously reported that CD4-negative CD3+ T-cells in peripheral blood are a characteristic immunophenotypic finding in AILD patients. Gene scan analysis for the TCR gamma chain an

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Maynadie, Marc M., Romain Casey, Karine Piazzon, Jean Claude Capiod, and Paule-Marie Carli. "Peripheral Blood Lymphocytes Subpopulations and Apoptotic Markers in Patients with Lymphoid Malignancies and in Controls: An Epidemiologic Case-Control Study." Blood 104, no. 11 (2004): 3858. http://dx.doi.org/10.1182/blood.v104.11.3858.3858.

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Abstract Few references ranges of normal peripheral blood lymphocytes subpopulations are available in the literature and fewer data were available regarding activation, proliferation and apoptosis antigen expression on such populations. We studied these parameters in patients included in an epidemiologic case-control study on risk factors of lymphoid malignancies conducted within European countries. Cell surface staining of peripheral blood lymphocyte antigens were analysed by multicolour flow cytometry in 300 cases and 300 controls. We determined CD3+, CD3+/CD4+, CD3+/CD8+, CD3−/CD56+CD16+, C

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Alotaibi, Faizah, Mark Vincent, Weiping Min, and James Koropatnick. "498 Downregulation of CD5 in CD8+ T tumour-infiltrating lymphocytes associates with increased level of activation and exhaustion." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A533. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0498.

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BackgroundCD5, a member of the scavenger receptor cysteine-rich superfamily, is a marker for T cells and a subset of B cells (B1a). CD5 associates with T-cell and B-cell receptors and impair TCR signaling1 2 and increased CD5 is an indication of B cell activation. Furthermore, CD5 levels on CD8+ T cell splenocytes were significantly increased after TCR/CD3 stimulation using ex vivo treatment with anti-CD3/anti-CD28 MAbs compared to non-stimulated CD8+ T splenocytes.3 Previous studies have shown a correlation between CD5 and anti-tumour immunity where CD5 knockout mice inoculated with B16F10 me

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June, C. H., P. S. Rabinovitch, and J. A. Ledbetter. "CD5 antibodies increase intracellular ionized calcium concentration in T cells." Journal of Immunology 138, no. 9 (1987): 2782–92. http://dx.doi.org/10.4049/jimmunol.138.9.2782.

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Abstract The binding of a variety of monoclonal antibodies to the CD5 (T, gp67) pan T cell differentiation antigen has been shown to potentiate T cell proliferation. In this paper we show that CD5 monoclonal antibodies cause increased intracellular free calcium concentration ([Ca2+]i) in T cells. An increase in [Ca2+]i occurred within 1 min in indo-1-loaded PBMC after the addition of CD5 monoclonal antibodies and cross-linking with a second step anti-mouse kappa light chain antibody. Cross-linking of CD5 was effective when done directly on the cell surface or by the administration of preformed

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Reddy, A. C., and K. S. Reddy. "Pediatric Patient With Neurological And Leukemic Peripheral Blood Involvement By Small Cell Variant Of ALK- Positive Anaplastic Large Cell Lymphoma (ALCL): Case Study." American Journal of Clinical Pathology 154, Supplement_1 (2020): S113—S114. http://dx.doi.org/10.1093/ajcp/aqaa161.248.

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Abstract Casestudy Anaplastic large cell lymphoma (ALCL), is a T-cell lymphoma typically consisting of large lymphoid cells including characteristic horseshoe- shaped hallmark cells. The rare small cell morphological variant of ALCL may pose a challenge in diagnosis, especially when the initial presentation is unusual. Results Our patient, a 7-year-old girl presented with a headache. A complete blood count showed leukocytosis and anemia. The smear was reported to have segmented neutrophils, reactive lymphocytes, and monocytes. A spinal tap was performed and flow analysis identified a minute ab

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Yoshioka, Keiji, and Jungo Terasaki. "CD7+, CD5+, CD4−, CD8−, and CD3−T-cell malignancy of the spleen after remission of invasive thymoma." American Journal of Hematology 48, no. 2 (1995): 141–42. http://dx.doi.org/10.1002/ajh.2830480230.

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Ferdousi, Shormin Ara, Mir Hasan Md Moslem, Kamrun Nahar, and Rowshon Ara Begum. "Immunophenotypic Characterization of Childhood Acute Leukaemia in A Tertiary Care Center of Bangladesh." Dhaka Shishu (Children) Hospital Journal 38, no. 2 (2023): 96–102. http://dx.doi.org/10.3329/dshj.v38i2.70593.

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Background: Leukemia is one of the most common tumors in children. Childhood acute leukaemia (AL) is a heterogenous disease. Immunophenotyping is an essential part of the modern diagnostic workup/for typing and subtyping and prognostic stratification of AL and thus for an appropriate treatment of these complex and heterogeneous diseases. Objectives: Objective of this study was to find immunophenotypic charectarization of childhood acute leukemia in children of Bangladesh. There is very limited study done on this subject in our country. Methods: This is a retrospective observational study

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Uckun, F. M., D. E. Myers, J. A. Ledbetter, S. E. Swaim, K. J. Gajl-Peczalska, and D. A. Vallera. "Use of colony assays and anti-T cell immunotoxins to elucidate the immunobiologic features of leukemic progenitor cells in T-lineage acute lymphoblastic leukemia." Journal of Immunology 140, no. 6 (1988): 2103–11. http://dx.doi.org/10.4049/jimmunol.140.6.2103.

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Abstract The specific binding of radioiodinated rIL-2 to fresh marrow blasts from T-lineage acute lymphoblastic leukemia (ALL) patients was initially investigated. The estimated number of radioiodinated rIL-2 molecules bound per blast ranged from undetectable to 1948. In colony assays, 72% of 32 cases analyzed showed a significant proliferative response to rIL-2, which depended on PHA-stimulated lymphocyte conditioned medium activation. Colony stimulation indices correlated with the number of radioiodinated rIL-2 molecules bound per blast but not with expression of CD25/Tac Ag on fresh marrow

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