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Dissertations / Theses on the topic 'CD62'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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1

Johansson, Joakim, Florence Sjögren, Mikael Bodelsson, and Folke Sjöberg. "Dynamics of leukocyte receptors after severe burns: An exploratory study." Linköpings universitet, Hälsouniversitetet, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67169.

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Background: Patients with burns are susceptible to organ failure, and there is indirect evidence that leukocytes may contribute to this process. They may change the expression of cell-surface receptors after certain stimuli, for example, the burn. We therefore aimed to assess the changes induced by the burn in the expression of leukocyte cell-surface receptors CD11b, CD14, CD16, and CD62L on the surface of PMNs and monocytes. We also wanted to examine the dynamics of this activation during the first week after the burn, and to relate it to the size of the injury. Methods: Ten patients with bur
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2

Ferreira, Kelly Pedrozo. "Caracterização da expressão de CD63 e KAI1/CD82 em células de câncer de vulva metastático e não metastático." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-20032019-123545/.

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O carcinoma de células escamosas de vulva (CECV) corresponde a cerca de 95% dos tumores vulvares. Apresenta bom prognóstico quando diagnosticado precocemente. O tratamento cirúrgico, embora eficaz, pode ser mutilante e acarreta em sérios danos psicossociais para as pacientes. Embora algumas pesquisas sobre os mecanismos que determinam os comportamentos clínico e biológico dos CECV tenham sido realizadas, ainda há muito a ser investigado. As tetraspaninas (TSPANs) são proteínas de membrana que interagem com diversas moléculas e estão envolvidas em diferentes processos fisiológicos como prolifer
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3

Sampaio, Raquel João Santos Ferreira Nunes. "The signaling role of the accessory receptors CD2 and CD6 in T cell activation." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7167.

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4

Sampaio, Raquel João Santos Ferreira Nunes. "The signaling role of the accessory receptors CD2 and CD6 in T cell activation." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7167.

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5

Fan, Hua. "Struktur-Funktions-Beziehungen der Dipeptidylpeptidase IV/CD26 (DPPIV/CD26)." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2005/215/index.html.

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6

Faulhaber, Fabrízia Rennó Sodero. "Expressão de marcadores de superfície de neutrófilos em recém nascidos ictéricos antes e após a fototerapia." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/179819.

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A icterícia por hiperbilirrubinemia indireta afeta mais de 60% dos recém-nascidos a termo. O tratamento, quando necessário, é realizado através da fototerapia. Não existem estudos na literatura avaliando os efeitos da fototerapia na função dos neutrófilos de recém-nascidos. O melhor entendimento da função dos neutrófilos nos recém-nascidos antes e após a fototerapia seria importante para avaliar as possíveis repercussões na expressão dos neutrófilos desencadeadas pelo tratamento fototerápico. O objetivo deste estudo foi avaliar e comparar a função dos neutrófilos, através da mensuração pela ci
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7

Trikić, Michael Zivojin. "Investigation of zebrafish tetraspanin cd63." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505348.

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Tetraspanin CD63 is highly conserved, found in a diverse range of species and has been implicated in a multitude of biological phenomena. Although its precise function is unknown, evidence suggests it has a role in intracellular trafficking. A homolog of CD63 is present in zebrafish of which little is known. The aim of this work was to investigate zebrafish cd63. This thesis first describes validation of zebrafish as a model for the study of CD63, and second investigates cd63 function in this system. Zebrafish cd63 was found to be 45% identical to human CD63 with conserved lysosomal targeting
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8

Duncan, Tod. "Identifying substrates of CDK2:cyclin A." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396250.

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9

Walker, Jennifer Anne. "CD22, autoimmunity and the B cell." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612192.

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10

Boonacker, Emil Paul. "Visualization of the moonlighting protein CD26/DPPIV." [S.l. : Amsterdam : s.n] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87658.

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11

Harris, Ruth V. "Phosphorylation of linker histones by cdc2 kinase." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336626.

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12

Colleypriest, Benjamin John. "The role of Cdx2 in Barrett's metaplasia." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524136.

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Barrett's metaplasia describes a condition in which the stratified squamous epithelium of the oesophagus switches to intestinal type columnar epithelium. The molecular mechanisms underlying the switch to intestinal epithelium is poorly understood but the transcription factor CDX2 has been implicated in the pathogenesis of Barrett's metaplasia and is sufficient to provoke an intestinal metaplasia in the stomach of transgenic mice. To address the molecular basis of Barrett’s, I developed an innovative explant system for adult mouse oesophageal epithelium in which the full repertoire of stratifie
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13

Rous, Brian Arthur. "Intracellular targeting of the lysosomal glycoprotein CD63." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624525.

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14

LEBEL-BINAY, SOPHIE. "Caracterisation fonctionnelle d'une nouvelle proteine transmembranaire : cd82." Paris 7, 1995. http://www.theses.fr/1995PA077277.

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La glycoproteine cd82 a ete identifiee et clonee dans notre laboratoire pour son expression preferentielle sur les lignees cellulaires sensibles a la lyse par les effecteurs nk/lak. Cette molecule de 267 acides amines (35 a 100 kda) est une proteine de type iii avec 4 segments transmembranaires, des extremites nh2 et cooh intracytoplasmiques et un grand domaine extracellulaire. Elle appartient a la famille des proteines tetra span transmembranaires (tst) qui comprend cd9, cd37, cd53, cd63 et cd81. Cd82. Elle est exprimee a la surface de nombreux types cellulaires. Son expression est augmentee
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15

Lam, Jennifer. "Dll1 is a Potential CDX2 Target Gene." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28896.

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The functional redundancy and peri-implantation lethality inherent to members of the CDX family has traditionally limited their investigation. As such, the development by our lab of a conditional null mutant, obliterating CDX activity in the mouse, has opened up an exploration of their additional roles. Along with the loss of caudal tissue and failure of neural tube closure, Cdx1/2 null mutants exhibit abnormal somites, an observation which is echoed by the misregulation of many somitic players including members of the Wnt and Notch signaling pathways upon microarray analysis. The replication
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16

Nair, Asmaa. "Expression ectopique du gène homéotique Cdx2 dans les pathologies du système digestif." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ003/document.

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Le facteur de transcription homéotique CDX2 est spécifiquement exprimé dans l’épithélium intestinal où il maintient l’identité, contrôle l’homéostasie et exerce une fonction suppresseur de tumeurs. Chez l’homme, une expression ectopique (hors de l’intestin) de CDX2 peut survenir, dans les métaplasies intestinales d’organes digestifs, considérées comme pré-cancéreuses. Ce travail de thèse visait à étudier les conséquences physiopathologiques de l’expression ectopique de CDX2. Nous avons développé et validé un modèle murin d’induction conditionnelle de CDX2 dans plusieurs organes digestifs. Nos
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17

Delhorme, Jean-Baptiste. "Etude des mécanismes de chimiorésistance dans les cancers digestifs : impact de CDX2 et des transporteurs ABC." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ119.

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La chimiorésistance est un enjeu majeur dans la prise en charge des patients atteints de cancers digestifs et peut se manifester par l’efflux de molécules cytotoxiques via la surexpression des transporteurs ABC. Le facteur de transcription CDX2 est un régulateur important de l’identité intestinale et agit comme gène suppresseur de tumeur dans le côlon. Il pourrait être impliqué dans des phénomènes de chimiorésistance des cancers colorectaux (CCR) car le transporteur MDR1/ABCB1 correspond à un de ses gènes cibles. Nous avons confirmé le rôle de CDX2 dans la chimiorésistance des CCR. Nous avons
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18

Meschini, Elisa. "Purine-based dual inhibitors of CDK2 and CDK7." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1363.

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Cyclin-Dependent Kinases (CDKs) play a fundamental role in eukaryotic cell cycle progression, particularly at cell cycle checkpoints, and are therefore important targets for anticancer drug discovery. Activation of CDK2 in complex with Cyclin A regulates entry into S phase of the eukaryotic cell cycle. CDK7, a dual-function enzyme, acts both as a CDK-Activating Kinase (CAK) and as a component of the general transcription factor TFIIH. However, experiments with MAT1-knockdown mice have shown that cell cycle arrest by CAK inhibition would not be detrimental for transcriptional activity in non-di
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19

Glasssmith, Gareth. "Characterisation of cdc2-related kinases from Trypanosoma brucei." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363169.

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20

Ko, Tun Kiat. "Characterization of Crk7-a novel Cdc2-related kinase." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621784.

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21

Dal, Ponte Silvana Teixeira. "Valor diagnóstico e prognóstico do CD64 na sepse." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/129642.

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INTRODUÇÃO: A sepse é uma resposta inflamatória sistêmica causada por infecção suspeita ou confirmada. As avaliações clínicas são essenciais para a sua detecção e tratamento precoce. Hemoculturas podem demorar até dois dias para produzir um resultado, e nem sempre são confiáveis. No entanto, estudos recentes sugeriram que a expressão de CD64 de neutrófilos pode ser uma alternativa sensível e específica para o diagnóstico de uma infecção sistêmica. OBJETIVO: Analisar a diferença de valores entre CD64 de indivíduos com síndrome de resposta inflamatória sistêmica (SIRS), e sepse suspeita ou confi
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LAGAUDRIERE, GESBERT CECILE. "Caracterisation biochimique et fonctionnelle de la tetraspanine cd82." Paris 11, 1997. http://www.theses.fr/1997PA112138.

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La proteine membranaire cd82 a ete identifiee a l'aide d'un anticorps monoclonal dirige contre les molecules de surface exprimees a la surface des cellules sensibles a la lyse par les effecteurs natural killer. L'adnc correspondant code pour une proteine de 267 acides amines appartenant a la famille des tetraspanines. Cette famille comprend des marqueurs leucocytaires, des antigenes tumoraux, et des proteines de schistosomes et drosophile. Le but de ce travail etait de caracteriser la proteine cd82 sur le plan biochimique et fonctionnel. Cette molecule est constituee d'une chaine proteique de
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23

Klein, Jörg. "Verwendung von Gene-Targeting-Techniken zur Etablierung neuer Mauslinien mit Mutationen in B-Zell-Signalwegen." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976107953.

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24

Balbinot, Camille. "Fonction et mode d'action du gène homéotique intestinal Cdx2 dans les cancers de l'intestin." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ006/document.

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Chez l’adulte, le facteur de transcription homéotique Cdx2 est spécifiquement exprimé dans l’intestin dont il maintient l’identité et contrôle l’homéostasie. Des études récentes menées chez l’homme ont identifié des formes de cancer colorectal de mauvais pronostic dans lesquelles l’expression de Cdx2 est très fortement réduite. Ce travail de thèse visait à étudier les conséquences physiopathologiques de la perte de fonction de Cdx2 dans l’intestin adulte. A partir d’un modèle murin d’invalidation conditionnelle et mosaïque de Cdx2, nos résultats montrent que la perte de Cdx2 conduit au dévelop
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Wöhner, Miriam [Verfasser], and Lars [Akademischer Betreuer] Nitschke. "Entwicklung einer knockin Mauslinie mit Expression von humanem CD22 zum Test therapeutischer Anwendungen künstlicher CD22-Liganden / Miriam Wöhner. Betreuer: Lars Nitschke." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1024608700/34.

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26

Soffar, Ahmed. "The Role of CDK2 and CDK9 in the Radiation Response of human HNSCC Cancer Cells." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-119407.

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The radiosensitivity of tumour cells depends mainly on their capacity to maintain genomic integrity. This requires efficient repair of radiation-induced DNA double strand breaks, a process governed by the cell cycle. Based on their functions in cell cycle regulation and DNA damage repair, we hypothesised that targeting of CDK2 and CDK9 modifies cancer cell response to radiotherapy. Therefore, we evaluated the significance of CDK2 and CDK9 for the cellular radiation response in a panel of human head and neck squamous cell carcinoma (HNSCC) cell lines. In order to achieve our goal, we performe
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Greenberg, David. "An analysis of CD2 expression and the use of CD2 sequences for thymus directed oncogenesis." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315354.

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28

Saandi, Thoueiba. "Le gène homéotique Cdx2 : fonctions in-vivo et régulation dans les pathologies intestinales." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ030.

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Le gène Cdx2 exerce de nombreuses fonctions au cours du développement embryonnaire. Son expression est maintenue spécifiquement dans l’épithélium intestinal adulte. Cdx2 est diminué dans les cancers colorectaux (CCR), favorisant la migration et la dissémination des cellules tumorales. Cette diminution de Cdx2 est réversible, suggérant une dérégulation du gène. Nous avons étudié d’une part les fonctions intestinales de Cdx2 au cours du développement et surtout chez l’adulte, et d’autre part les mécanismes moléculaires associés à la dérégulation de Cdx2 dans les CCR.Une approche d’invalidation c
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Vàzquez, Prat Berta. "Estudi de la regulació transcripcional del gen de CD69." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/51573.

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CD69 és una lectina tipus C amb orientació tipus II, que participa en la migració de limfòcits i la secreció de citocines. CD69 s'expressa a la gran majoria de leucòcits durant processos infecciosos, autoimmunitaris i neoplàsics, i s'utilitza àmpliament com a marcador de l'activació del sistema immunitari. El seu targeting amb anticossos monoclonals ha resultat útil en el tractament de malalties en diferents models animals i, per tant, per esbrinar quins són els mecanismes que controlen la seva expressió a la superfície cel•lular és molt important. L’expressió de CD69 és induïble i està fortam
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Mateo, González Francesca. "Regulació del complex ciclina A-CDK2 per l'acetilasa PCAF." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/914.

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Els complexes ciclina-CDK són elements clau perquè el cicle cel·lular es doni de manera ordenada. Estan regulats a diferents nivells ja que les seves funcions són essencials per a la correcta progressió del cicle. El primer nivell de regulació és la interacció entre la ciclina i la CDK. En segon lloc, aquestes proteïnes poden experimentar fosforilacions i defosforilacions activadores i inhibidores. En tercer lloc, aquests complexes poden ser inhibits per la interacció amb CKIs (CDK Inhibitors). Finalment, la localització subcel·lular també és una manera de regular l'activitat d'aquests complex
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Hayles, J. "Suppressor analysis of the cdc2 gene in Schizosaccharomyces pombe." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377076.

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Brown, Marion Hanbury. "Physical interactions of the CD2 antigen." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277634.

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33

Schöpp, Sebastian. "Molekularbiologische Identifizierung und immunophänotypische Charakterisierung der malignen Zellen beim Sézary Syndrom unter Berücksichtigung von Klinik und Prognose." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15053.

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Für die Diagnose und das Monitoring des Sézary Syndrome haben sich zwei hauptsächliche Herangehensweisen etabliert: die Immunophänotypisierung und PCR basierte T-Zell-Rezeptor (TCR)-Gen-Rearrangement Analyse. Die verminderte Expression von T-Zell-Antigenen auf im Blut zirkulierenden Lymphozyten ist beim Sézary Syndrom beschrieben, insbesondere der Antigene CD7 und CD26. Jedoch ist die Verteilung des genetisch definierten Tumorzellklons auf die CD7 und CD26 positiven bzw. negativen Subpopulationen bisher nicht untersucht worden. Aus diesem Grund etablierten wir eine qualitative sowie eine quant
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Mongrain, Sébastien. "Caractérisation du mécanisme de régulation de Cdx2 par la MAP kinase p38 et implication de Cdx2 dans la différenciation des cellules épithéliales intestinales." [S.l. : s.n.], 2006.

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Mongrain, Sébastien. "Caractérisation du mécanisme de régulation de Cdx2 par la MAP kinase p38 et implication de Cdx2 dans la différenciation des cellules épithéliales intestinales." Mémoire, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/3855.

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Les gènes Cdx encodent des facteurs de transcription possédant un rôle très important dans le développement et le maintien de l'épithélium intestinal. Cdx2 joue un rôle central dans la différenciation des cellules épithéliales intestinales. Celui-ci permet d'activer l'expression de plusieurs enzymes digestifs et d'induire l'expression de protéines de jonctions cellulaires. Nous avons démontré que la MAP kinase p38 est impliquée dans le processus de différenciation, entre autres, en activant le facteur de transcription Cdx2. La MAP kinase p38 retrouvée dans le noyau des cellules différenciées l
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Caillava, Céline. "Rôle de Cdk2 dans la prolifération des cellules souches neurales et des progéniteurs d'oligodendrocyte adultes au cours de la myélinisation et de la remyélinisation." Paris 6, 2009. http://www.theses.fr/2009PA066143.

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Il a été montré in vitro que Cdk2, responsable de la transition G1/S du cycle cellulaire, contrôlait spécifiquement la prolifération des OPC et que son expression était réprimée chez les OPC adultes. Au cours de nos travaux, nous avons démontré in vivo que bien que Cdk2 ne soit pas essentielle à la prolifération des OPC, l’oligodendrogenèse et la myélinisation au cours du développement, elle intervient dans la prolifération des OPC adultes en réponse à une démyélinisation focale. En effet, dans ce contexte, en absence de Cdk2, la prolifération des OPC dans la zone sous-ventriculaire et à la lé
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Bruneau, Joannie. "Gata4 et Cdx2 sont des régulateurs transcriptionnels intestinaux du gène encodant la protéine sécrétoire de type lectine Pap1." Mémoire, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5542.

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Gata4 est un facteur de transcription exprimé par les entérocytes. Nos études ont démontré que Gata4 pouvait réguler l'expression de Pap1 chez le rat. Ce gène encode pour une protéine sécrétoire de type lectine impliquée dans le contrôle de la prolifération bactérienne. Puisqu'il a été démontré que des lectines antibactériennes de la famille Pap sont sécrétées dans la lumière intestinale en réponse à des stimuli inflammatoires, le but de cette étude était de définir l'implication transcriptionnelle de Gata4 dans la réponse inflammatoire des cellules épithéliales intestinales. Afin de caractéri
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Quaresma, Paula Gabriele Fernandes 1987. "Estudo da regulação da proteína CDC2-Like Kinase (Clk2) em hipotálamo e fígado de camundongos controles e obesos = CDC2-Like Kinase (Clk2) hypothalamic and hepatic regulation in lean and obese mice." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311558.

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Orientador: Patrícia de Oliveira Prada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T14:12:45Z (GMT). No. of bitstreams: 1 Quaresma_PaulaGabrieleFernandes_M.pdf: 949361 bytes, checksum: 237d0acc0b5bc5358adba045381b4a92 (MD5) Previous issue date: 2012<br>Resumo: O hipotálamo é um órgão crucial na regulação do balanço energético por integrar sinais hormonais e nutricionais de órgão periféricos. O hormônio produzido pelo pâncreas - insulina - e o hormônio derivado de células adiposas - leptina- reconhecidam
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Schönfeld, Nicole. "Isolation und molekulare Charakterisierung des Apoptose-induzierenden Metastasensuppressors C33/CD82." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-8675.

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今宿, 芳郎. "シロイヌナズナのCDC2遺伝子群の研究". 京都大学 (Kyoto University), 1997. http://hdl.handle.net/2433/202465.

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Verzeaux, Laurie. "Etude de l'interaction du TIMP-1 avec ses récepteurs." Thesis, Reims, 2015. http://www.theses.fr/2015REIMS040/document.

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Le TIMP-1, inhibiteur naturel des métalloprotéinases matricielles, exerce des effets pléïotropes indépendants de l'inhibition des MMPs et participe au développement de certains cancers et maladies neurodégénératives. Ces effets cytokiniques du TIMP-1 impliquent sa liaison à des récepteurs membranaires dont certains sont caractérisés, la glycoprotéine CD63/intégrine beta 1 et le complexe pro MMP-9/CD44. Cependant les acides aminés ou les domaines du TIMP-1 se liant à ces récepteurs ne sont pas identifiés. Les travaux réalisés au cours de cette thèse mettent en évidence un nouveau récepteur du T
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Fujiwara, Ippei. "Three essays on dynamic general equilibrium models." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:b963d031-cd68-4bee-91b7-4541e5d600d2.

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This thesis aims at contributing to the existing studies in the dynamic stochastic general equilibrium model, particularly in the new Keynesian models, on three aspects. It consists of three chapters. Chapter 2 is on “Dynamic new Keynesian Life-Cycle Model.” Chapter 3 is on “Re-thinking Price Stability in an Economy with Endogenous Firm Entry: Real Imperfections under Product Variety.” Chapter 4 is on “Growth Expectation.” Abstracts of each Chapter are as follows. In Chapter 2, we first construct a dynamic new Keynesian model that incorporates life-cycle behavior a la Gertler (1999), in order
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Howard, David John. "Colouring the nation : race and ethnicity in the Dominican Republic." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:e7cc675f-cd66-4827-a52f-9cd1765f3777.

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This thesis analyses the importance of race for the construction of nation and ethnicity in the Dominican Republic, a situation in which racial ancestry and spatial proximity to Haiti are paramount. Firstly, racial legacies are of primary importance among a Dominican population where cultural, linguistic and religious differences are limited. Racial differences are manipulated through the unequal standing and significance given to European, African and indigenous ancestries. European and indigenous heritages in the Dominican Republic have been celebrated at the expense of an African past. Seco
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Жиляк, Іван Дмитрович. "Акваамінодифосфати Co2+, Ni2+, Cu2+, Zn2+ та Cd2". Дис. канд. хім. наук, Нац. аграрний ун-т, 2006.

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45

Stell, David Andrew. "Anti-CD2 mediated prolongation of allograft survival." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340254.

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46

Chen, Ho Ann. "Biophysical characterisation of rat CD2 domain 1." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392332.

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Junior, Walter Filgueira de Azevedo. "Introdução à biocristalografia com o estudo estrutural da quinase dependente de ciclina 2 (CDK2) complexada com inibidores." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-17032014-173549/.

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O ciclo celular é controlado pela atividade das quinases dependentes de ciclinas (Ciclin-dependent kinases, CDKs). As CDKs são inativas como monômeros, e a sua ativação necessita da ligação às ciclinas, uma família diversa de proteínas cujos os níveis oscilam durante o ciclo celular, e fosforilação pela CAK (CDK-activating kinase) sobre um resíduo de treonina específico. As CDKs são capazes de fosforilar muitas proteínas que estão envolvidas nos eventos do ciclo celular, incluindo histonas e proteínas supressoras de tumores como pRb. Além da função de regulação positiva das ciclinas e CAK, mui
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48

Perez, Mario Castro Alvarez. "Epidemiologia, diagnóstico, marcadores de imunocompetência e prognóstico da sepse." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1447.

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Apesar de uma diversidade de estudos científicos, em que dezenas de milhares de pacientes foram analisados e tratados, a sepse continua sendo um grande desafio para a medicina contemporânea. Investigações bem conduzidas levaram a uma reavaliação do modelo clássico da sepse, tradicionalmente vista como um processo descontrolado de hiperinflamação sistêmica, uma vez que se observou a existência de uma atividade antiinflamatória ao longo do seu curso evolutivo. Nesse contexto, o comportamento do sistema imune inato se assemelha ao de indivíduos idosos submetidos ao fenômeno da imunossenescência,
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Azzopardi, Laura. "Lymphodepletion with repeated cycles of alemtuzumab and secondary autoimmunity after alemtuzumab treatment of relapsing-remitting multiple sclerosis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275142.

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Background: Relapsing-remitting multiple sclerosis (RRMS) is an autoimmune inflammatory disorder of the central nervous system, with significant morbidity and mortality. The lymphocyte depleting, anti-CD52 monoclonal antibody alemtuzumab is a highly effective treatment option in RRMS, though associated with high rates of secondary autoimmune disorders. As alemtuzumab is now in routine clinical use, following licensing in Europe and the US, understanding the effects of repeated treatment cycles and reducing the risk of secondary autoimmunity is timely and essential. In this thesis, I explore ho
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Minar, Phillip. "Validation of Neutrophil CD64 Blood Biomarkers to Detect Mucosal Inflammation in Pediatric Crohn’s Disease." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1515508268721564.

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