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Relevant bibliographies by topics / CD8

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Academic literature on the topic 'CD8'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "CD8"

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Chatila, T. A., and R. S. Geha. "Phosphorylation of T cell membrane proteins by activators of protein kinase C." Journal of Immunology 140, no. 12 (1988): 4308–14. http://dx.doi.org/10.4049/jimmunol.140.12.4308.

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Abstract Activation of the enzyme protein kinase C (PKC) plays an important role in T cell activation. We investigated the phosphorylation of CD2, CD3, CD4, CD5, CD7, CD8, CD28 (Tp44), CD43 (sialophorin, gp115), and LFA-1 after incubation of human PBMC with the (PKC) activator PMA. These proteins were chosen for their role in transmembrane signal transduction (CD2, CD3, CD5, CD28, CD43), cell-cell interaction and adhesion (CD2, CD4, CD8, and LFA-1), or involvement in immunodeficiency states (CD43, CD7). CD5, CD7, CD43, and the alpha-chain of LFA-1 were found to be constitutively phosphorylated

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Semchenkova, Alexandra, Ekaterina Mikhailova, Irina Demina, et al. "Analysis of Antigen Expression in T-Cell Acute Lymphoblastic Leukemia by Multicolor Flow Cytometry: Implications for the Detection of Measurable Residual Disease." International Journal of Molecular Sciences 26, no. 5 (2025): 2002. https://doi.org/10.3390/ijms26052002.

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Multicolor flow cytometry (MFC) is a key method for assessing measurable residual disease (MRD) in acute lymphoblastic leukemia (ALL). However, very few approaches were developed for MRD in T-cell ALL (T-ALL). To identify MRD markers suitable for T-ALL, we analyzed the expression of CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD34, CD45, CD48, CD56, CD99, and HLA-DR in T-ALL patients at diagnosis. The median fluorescence intensities (MFIs) of surface CD3, CD4, CD5, CD7, CD8, CD45, CD48, CD99, and CD16+CD56 were also evaluated at Day 15 and the end-of-induction (EOI). The MFC data from 198 pediatric T-

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Зыблева, С. В., and С. Л. Зыблев. "Cluster Analysis of Leukocyte Subpopulations in Kidney Transplantation." Гематология. Трансфузиология. Восточная Европа, no. 2 (November 8, 2021): 168–75. http://dx.doi.org/10.34883/pi.2021.7.2.005.

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Цель. Выявить варианты иммунного реагирования у пациентов при трансплантации почки на основе кластерного анализа, характеризующие течение посттрансплантационного периода. Материалы и методы. Обследовано 104 реципиента почечного трансплантата с терминальной стадией хронической болезни почек, которым выполнена трансплантация аллогенной почки, а также 90 здоровых добровольцев, составивших группу сравнения. Оценены уровни лейкоцитов с использованием метода проточной цитометрии по безотмывочной технологии с использованием моноклональных антител (Beckman Coulter и BD, США) CD4 PС7, CD8 FITC, CD3 PС5

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Zybleva, S. V., and S. L. Zyblev. "Immunological cluster complexes in kidney transplantation." Medical Immunology (Russia) 24, no. 1 (2022): 69–80. http://dx.doi.org/10.15789/1563-0625-icc-2212.

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Laboratory tests are significant for the detection of immunopathological disorders in kidney transplantation. As a rule, the choice of tests is carried out individually and is based on the clinical characteristics and the presumptive diagnosis. Most often, in patients after kidney transplantation, atypical and not always standard changes in immunological parameters are observed, which is associated with a combination of many factors leading to different immune responses. All this served as the basis for typing immunological parameters in renal allograft recipients using one of the methods of s

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Tjønnfjord, G. E., O. P. Veiby, R. Steen, and T. Egeland. "T lymphocyte differentiation in vitro from adult human prethymic CD34+ bone marrow cells." Journal of Experimental Medicine 177, no. 6 (1993): 1531–39. http://dx.doi.org/10.1084/jem.177.6.1531.

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Pluripotent lymphohematopoietic stem cells are probably confined to bone marrow cells expressing CD34 surface molecules. To investigate the capacity of adult human CD34+ bone marrow cells to differentiate along the T lymphoid lineage, we plated purified CD34+ cells from healthy adults in liquid culture on adherent thymic stromal cells prepared from HLA- or blood group-mismatched postnatal thymic tissue. We show that purified CD34+CD3-CD4-CD8- bone marrow cells contained progenitors with the ability to differentiate into CD4+ and CD8+ T lymphocytes expressing surface (s)CD3 and T cell receptor

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Damle, N. K., and L. V. Doyle. "Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4+CD29+CD45R- memory T lymphocytes." Journal of Immunology 143, no. 6 (1989): 1761–67. http://dx.doi.org/10.4049/jimmunol.143.6.1761.

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Abstract Although both IL-2 and IL-4 can promote the growth of activated T cells, IL-4 appears to selectively promote the growth of those helper/inducer and cytolytic T cells which have been activated via their CD3/TCR complex. The present study examines the participation of CD28 and certain other T cell-surface molecules in inducing T cell responsiveness to IL-4. Purified small high density T cells were cultured in the absence of accessory cells with various soluble anti-human T cell mAb with or without soluble anti-CD3 mAb and their responsiveness to IL-4 was studied. None of the soluble ant

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Haynes, B. F., and C. S. Heinly. "Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment." Journal of Experimental Medicine 181, no. 4 (1995): 1445–58. http://dx.doi.org/10.1084/jem.181.4.1445.

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To determine events that transpire during the earliest stages of human T cell development, we have studied fetal tissues before (7 wk), during (8.2 wk), and after (9.5 wk to birth) colonization of the fetal thymic rudiment with hematopoietic stem cells. Calculation of the approximate volumes of the 7- and 8.2-wk thymuses revealed a 35-fold increase in thymic volumes during this time, with 7-wk thymus height of 160 microM and volume of 0.008 mm3, and 8.2-wk thymus height of 1044 microM and volume of 0.296 mm3. Human thymocytes in the 8.2-wk thymus were CD4+ CD8 alpha+ and cytoplasmic CD3 epsilo

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Abbott, Daniel, Steven Kroft, Maria Hintzke, et al. "Immunophenotypic Analysis of Peripheral T-Cell Lymphomas: A Single-Center Retrospective Review of Flow Cytometric Analysis." American Journal of Clinical Pathology 152, Supplement_1 (2019): S109. http://dx.doi.org/10.1093/ajcp/aqz121.012.

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Abstract Background Peripheral T-cell lymphomas (PTCLs) are heterogenous, mature T-cell neoplasms that are a diagnostic challenge, requiring a combination of morphologic assessment and ancillary studies. Flow cytometry (FC) is a tool used routinely in lymphoma diagnosis; however, most analyses are limited to B-cell evaluation and pathologists generally lack experience evaluating for PTCL. We aimed to describe the immunophenotypic aberrancies observed by FC in PTCL. Design PTCLs with FC were collected, excluding primary leukemic processes. Four- and eight-color FC data were reanalyzed with the

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Akhmatova, E. A., E. V. Sorokina, I. Zh IShubina, et al. "Innate immunity cells in a model of acute psoriasis-like inflammation in mice." Russian Journal of Biotherapy 22, no. 4 (2023): 43–51. http://dx.doi.org/10.17650/1726-9784-2023-22-4-43-51.

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Background. Experimental animal models of psoriasis helped to clarify the functions of inflammatory mediators, to reveal the contribution of innate or adaptive immune mechanisms, keratinocytes to the development and maintenance of inflammation in psoriasis.Aim. To study the subpopulation composition of immune cells of blood, skin, lymphoid organs and compare two methods of isolation of cells from the skin.Materials and methods. The study included 46 mice of the C57BL / 6 line, which were divided into 2 groups: experimental (n = 24) to reproduce a model of acute psoriasis-like dermatitis using

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Terstappen, LW, S. Huang, and LJ Picker. "Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow." Blood 79, no. 3 (1992): 666–77. http://dx.doi.org/10.1182/blood.v79.3.666.bloodjournal793666.

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Using multidimensional flow cytometry we have defined and quantified the human T-cell differentiation pathway, focusing on those events occurring among the most immature thymocytes and putative bone marrow (BM) T-precursors. Early thymocytes were found to express the CD34 antigen and consisted of a mean 1.2% of cells within human pediatric (n = 9) and 2.0% in fetal thymi (n = 4). All CD34+ thymocytes were atypical blast by morphology, expressed intracytoplasmatic, but not cell surface, CD3, and were cell surface CD2+, CD5+, CD7+, CD38+, CD45+, CD45RA+, CD49d+, and LECAM-1(Leu8)high. CD34high t

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Dissertations / Theses on the topic "CD8"

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Thomas, Ian James. "Investigation of the differential effects of CD80 and CD86 costimulation on CD8 T cells." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424069.

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Eichelbauer, Dirk. "In-vitro-Untersuchungen zur Stimulation von humanen TZR-[alpha]/[beta]+-CD4-CD8-doppeltnegativen [TZR-alpha-beta-CD4-CD8-doppeltnegativen] T-Lymphozyten." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970313373.

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Cauchy, Pierre. "Rôle et contexte transcriptionnel du facteur de transcription Ets1 au cours transition CD4- CD8- à CD4+ CD8+ de la tymopoïèse αβ". Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX22135.

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ETS1 est un facteur de transcription (FT) spécifique transposé dans les leucémies aigües. Le rôle essentiel d'ETS1 a été décrit au cours de l'hématopoïèse, plus particulièrement dans la différenciation lymphocytaire T. Son expression temporelle coordonnée participe au contrôle des transitions du stade double négatif (DN) CD4-/CD8- au stade double positif (DP) CD4+/CD8+jusqu'au stade simple positif (SP) CD4+ ou CD8+. Au cours de l'ontogenèse T, ETS1 transactive notamment l'expression des chaînes β et α du récepteur des cellules T (TCR). Nous avons criblé à grande échelle les cibles d'ETS1 aux s

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Pinheiro, CatiÃssia Dantas. "CÃlulas CD3+, CD4+, CD8+, CD3-CD16+CD56+ e CD19+ em sangue perifÃrico de pacientes com hansenÃase e indivÃduos saudÃveis." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16323.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A hansenÃase Ã uma doenÃa granulomatosa, infecto-contagiosa causada pelo Mycobacterium leprae. Trata-se de uma infecÃÃo crÃnica com amplo espectro de respostas imunes celulares em humanos. Possui alto poder infectante e baixo poder patogÃnico. Este estudo tem como objetivo quantificar e comparar leucÃcitos e subpopulaÃÃes de linfÃcitos T totais (CD3+), T auxiliares (CD3+CD4+), T citotÃxicos (CD3+CD8+), B (CD19+) e NK (CD3-CD16+CD56+) em sangue perifÃrico de indivÃduos com hansenÃase e controles saudÃveis. Os pacientes foram prove

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Pinheiro, Catiússia Dantas. "Células CD3+, CD4+, CD8+, CD3-CD16+CD56+ e CD19+ em sangue periférico de pacientes com hanseníase e indivíduos saudáveis." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/15425.

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PINHEIRO, Catiússia Dantas. Células CD3+, CD4+, CD8+, CD3-CD16+CD56+ e CD19+ em sangue periférico de pacientes com hanseníase e indivíduos saudáveis. 2013. 65 f. Dissertação (Mestrado em Patologia) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2013.<br>Submitted by denise santos (denise.santos@ufc.br) on 2016-03-09T13:41:07Z No. of bitstreams: 1 2013_dis_cdpinheiro.pdf: 775643 bytes, checksum: 2d4939ef2f883a155737695a2e7c759a (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2016-03-09T15:22:37Z (GMT) No. of bitstreams: 1 2013_dis_cdpinheir

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Khan, Qasim. "Regulation of apoptosis in CD4§-CD8§- Ãß§+ T cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29310.pdf.

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Tyznik, Aaron Jacob. "CD4+ T cell help for CD8+ T cell responses /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8314.

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Behrendt, Anne. "Differential antigen dependency of CD4+ and CD8+ T cells." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171521.

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Anand, Arthi. "Characterization of CD3+CD4-CD8- (double negative) T cells in patients with systematic lupus erythematosus (SLE)." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1445261/.

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Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized serologically by B cell hyperactivity and a panoply of autoantibodies against nuclear, cytoplasmic and cell surface antigens. It is thought that T cells are involved in this process and more recently it has been suggested that the CD4+ CD8+, i.e.double negative (DN) T cells, might be important. As a start to understanding the contribution of DN T cells to disease pathogenesis in SLE, the percentages of DN T cells were determined and it was found that otp but not y5 DNT cells were significantly increased in pati

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Freitag, Kimberly A. "Effects of Acute Nutritional Deprivation on Lymphocyte Subsets and Membrane Function in Cats." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/46484.

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Identification of patients with suboptimal nutritional status allows for early treatment intervention. Currently, no definitive test of nutritional status exists. Therefore, this study was conducted to identify possible functional indicators of acute nutritional deprivation. The effects of total nutritional deprivation and subsequent refeeding on lymphocyte functions and subpopulations were examined in 23 healthy cats. Peripheral blood samples were analyzed at various times during fasting and refeeding periods. During the fasting period, decreases were observed in leukocyte number (day 4;

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Books on the topic "CD8"

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Jönsson, Jan-Ingvar. Accessory molecules in T lymphocyte activation: The role of CD4 and CD8. Dept. of Tumor Immunology, Wallenberg Laboratory, Univ. of Lund, 1990.

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Kay, Lyndsey Sara. Anti-B-cell lymphoma activity mediated by CD3+CD4-CD8- T cells activated in vitro or in vivo. National Library of Canada, 2003.

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McDonagh, Mark Christian. An investigation of CD8 T lymphocyte development and function. University of Manchester, 1994.

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Thefeld, Sabina Elisabeth. CD4+- und CD8+-T-Lymphozyten-Subpopulation im peripheren Blut FeLV-seropositiver Katzen mit natürlich erworbener Infektion. [s.n.], 1992.

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Ford, Megan. The role and mechanism of B6/1pr TCR[alpha beta]+CD4-CD8- T cells in immune response regulation. National Library of Canada, 2001.

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Metzner, Karin. Zur CD8+-T-Lymphozyten: Interleukin-16 und Identifikation und Charakterisierung anderer sezernierter Proteine. [s.n.], 1997.

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Dumont, Caroline R. Identifying the autoantigen of a diabetogenic CD8 T cell clone isolated from Young NOD mice. s.n.], 1999.

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Steffens, Hans-Peter. Einfluss einer präemptiven CD8-T-Zell-Therapie auf die Menge an latenter viraler DNA und das Rekurrenzrisiko nach Knochenmarktransplantation und Cytomegalovirus-Infektion. [s.n.], 1998.

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Matthes, Michaela Christine. Molekulare Analyse der Antigen-spezifischen T-Zellantwort am Beispiel des zytotoxischen T-Zellklones CW3/1.1: Charakterisierung des Antigen-spezifischen T-Zellrezeptors und dessen Interaktion mit dem akzessorischen Molekül CD8 durch Gentransfer. [s.n.], 1992.

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Sondermann, Bernd. Parteienfamilie ohne Zusammenhalt?: Programmatische Gegenreden von CDU, CDA und Tories auf die neue Sozialdemokratie. Lang, 2006.

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Book chapters on the topic "CD8"

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Nelson, Robert P. "CD8 Alpha (CD8A) Deficiency." In Encyclopedia of Medical Immunology. Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4614-8678-7_96.

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Kleine, T. O. "Liquor-CD4/CD8-Quotient." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_1913-1.

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Kleine, T. O. "Liquor-CD4/CD8-Quotient." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1913.

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Nelson, Robert P. "CD8 Alpha (CD8A) Deficiency." In Encyclopedia of Medical Immunology. Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4614-9209-2_96-1.

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Renz, H., and B. Gierten. "CD8." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_695.

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Renz, H., and B. Gierten. "CD8." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_695-1.

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Gluzman, D. F., I. V. Abramenko, N. I. Belous, et al. "CD7+CD4-CD8-Blast Cells in Acute Leukemia." In Acute Leukemias VI. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60377-8_43.

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Peters, Nils, Martin Dichgans, Sankar Surendran, et al. "CD8 Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_302.

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Wang, Anqi, Matthias Noll, and Stefan Wesarg. "Tumorsegmentierung in CD3/CD8-gefärbten Histopathologien." In Informatik aktuell. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46224-9_60.

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Collins, T. L., W. C. Hahn, B. E. Bierer, and S. J. Burakoff. "CD4, CD8 and CD2 in T Cell Adhesion and Signaling." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78253-4_18.

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Conference papers on the topic "CD8"

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Theodoro, Flavia Cristine Medeiros, Luiz Eduardo Nazario Mendes, Lucas de Oliveira Costa, et al. "Identificação dos casos de doenças linfoproliferativas de células T em pacientes de Natal, Rio Grande do Norte, entre 2020 e 2022." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.12275.

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Objetivo: As doenças linfoproliferativas crônicas (DLPC) pertencem a um grupo de neoplasias linfoides caracterizadas pela expansão monoclonal e pelo acúmulo de linfócitos maduros, podendo ser de células B, T e células natural Killer (NK). As doenças linfoproliferativas crônicas de células T (DLPC-T) são menos frequentes e têm o diagnóstico estabelecido pela detecção de fenótipos aberrantes, tais como alterações da relação CD4/CD8, presença de células T CD4+/CD8+ e ausência de antígenos Pam-T, como CD3 e CD7. A caracterização dessas entidades é, na maioria das vezes, mais difícil quando compara

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Наджафова, В. А. к. "Оценка нарушений субпопуляций лимфоцитов у детей с железодефицитной анемией". У General question of world science. Наука России, 2021. http://dx.doi.org/10.18411/gq-31-07-2021-03.

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Статья посвящена проблеме нарушения иммунитета у детей с железодефицитной анемией (ЖДА), проживающих в Азербайджане. Были выявлены более низкие показатели клеточного иммунитета (CD3, CD4, CD8). Относительное количество клеток CD3 в общей группе детей с ЖДА составило 52,7±4,35%, в контрольной группе - 62,6±5,49%, р<0,05. Проведенные исследования выявили положительную корреляцию клеток CD3, CD4, CD8 с гемоглобином и сывороточным железом. Результаты высокой силы связи коэффициента корреляции сывороточного железа с относительным количеством клеток CD3 и CD4 в общих группах детей с ЖДА (r = 0,8)

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Kasteckas, JB, N. Medeiros Junior, AC Carvalho, AR Rinaldi, and RMF Souza. "SÍNDROME DE SÉZARY: RELATO DE CASO EM UM PACIENTE DE HOSPITAL TERCIÁRIO." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.6236.

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Objetivo: Relatar um caso clínico de síndrome de Sézary (SS), destacando a importância do estudo morfológico das células de Sézary. Método: Consulta aos dados clínicos em um prontuário eletrônico; realização de hemograma automatizado e revisão morfológica por microscopia óptica convencional. Caso: M. A. O., 56 anos de idade, sexo feminino, apresentando ao exame físico áreas de eritrodermia com ilhas de pele sã e atrofia em palmas, sendo aventada a hipótese diagnóstica de micose fungoide. Exames complementares: Hb 12,6; Ht 37,6; leucócitos 10190 (neutrófilos 5620 + linfócitos 3780); pesquisa de

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Bento, Laiz Cameirão, Priscila Carmona Miyamoto, Flavia Arandas de Sousa, et al. "Avaliação do desempenho do Kombitest na quantificação de linfócitos T CD4 e CD8." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.11794.

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Objetivo: A utilização de anticorpos monoclonais conjugados para a quantificação de linfócitos T na rotina diagnóstica laboratorial é de grande importância, pois minimiza erros de pipetagem, diminui o custo e otimiza o tempo, proporcionando melhoria na qualidade e na produtividade do processo. Este trabalho teve o objetivo de comparar o desempenho de dois painéis em um teste de quantificação de linfócitos T CD3, CD4 e CD8. Método: Neste estudo, utilizamos um total de 10 amostras de sangue periférico. Para cada teste utilizamos 100ul de sangue periférico. As amostras foram marcadas com o seguin

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Borges, JPD, ISMA Sousa, TF Silva, et al. "APLICAÇÃO DA IMUNOFENOTIPAGEM POR CITOMETRIA DE FLUXO NO DIAGNÓSTICO DE DOENÇA LINFOPROLIFERATIVA." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.7397.

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Objetivo: A síndrome de Sézary (SS) é uma variante leucêmica rara que corresponde a 2% dos casos de linfomas cutâneos de células T. Caracteriza-se por eritrodermia, linfadenopatia periférica e presença de células de Sézary na pele, nos linfonodos e no sangue. As células de Sézary são linfócitos T maduros, de tamanho pequeno a médio, com núcleos convolutos, exibindo fenótipo CD3+, CD4+, CD8-, com perda variável da expressão de CD7(1,2). Este relato objetivou descrever e correlacionar os achados laboratoriais na elucidação de um caso de evolução de micose fungoide para SS. Método: Paciente E. S.

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Sousa, I., BL Scarpato, CMR Franzon, AOM Wagner, and ACW Lopes. "RELATO DE CASO: DIAGNÓSTICO DIFERENCIAL ENTRE LINFOMA LINFOBLÁSTICO T E TIMOMA." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.6177.

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Objetivo: O linfoma linfoblástico T (LBL-T) e o timoma são neoplasias mediastinais primárias distintas que podem ter apresentações clínicas, características morfológicas e imunofenotípicas semelhantes. Um diagnóstico preciso é importante, uma vez que as abordagens de tratamento diferem consideravelmente. O presente estudo relata o caso de uma paciente jovem com massa mediastinal, no qual foi necessário fazer o diagnóstico diferencial entre timoma e LBL-T. Método: Paciente do sexo feminino, 20 anos de idade, com massa mediastinal, tamponamento cardíaco e síndrome de compressão de veia cava. O m

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Theodoro, Flávia Cristine M., Luiz Eduardo Nazario Mendes, Lucas de Oliveira Costa, et al. "Estudo de caso: citometria de fluxo no diagnóstico de leucemia de células vilosas." In Resumos do 56º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2024. https://doi.org/10.5327/1516-3180.142s1.12213.

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Objetivo: A leucemia de células vilosas (LCV), também conhecida como hairy cell leukemia (HCL), compreende uma doença linfoproliferativa maligna de células B maduras, clonal, caracterizada pela presença de linfócitos anômalos com projeções citoplasmáticas semelhantes a fios de cabelo. O comportamento clínico dessa doença está relacionado à infiltração da medula óssea (MO), baço, entre outros tecidos linfoides, podendo acometer o sangue periférico (SP). Os achados laboratoriais da LCV compreendem a citopenia periférica e medular com presença de leucopenia, trombocitopenia e anemia na maioria do

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Lins, Lucas Costa, Iana Carneiro Pinto, Nathalia Lima Schramm dos Santos, Vitor de Oliveira Silva, and Marcos Lázaro da Silva Guerreiro. "INFLUÊNCIA DA QUIMIOTERAPIA NA RESPOSTA IMUNOLÓGICA CELULAR EM CAMUNDONGOS INFECTADOS COM AS CEPAS Y E COLOMBIANA DO TRYPANOSOMA CRUZI." In I Congresso Brasileiro de Parasitologia Humana On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/741.

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Introdução: Estudos sugerem que o tratamento quimioterápico estimula o sistema imunológico em camundongos infectados com cepas do T. cruzi. Objetivo: avaliar a influência do tratamento com Benzonidazol sobre a resposta imunológica celular em camundongos infectados com a cepa Y (suscetível) e Colombiana (resistente). Material e métodos: 150 camundongos, subdivididos em: Infectados tratados cepa Y (YT) e não tratados (Y-NT); Colombiana tratados (COL-T) e não tratados (COL-NT), Tratados não infectados (TNI) e Controles sem tratamento (CI). O inóculo foi 1,0 x 104 por via intraperitoneal. Os proce

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"REHABILITATION MEASURES IN PATIENTS WITH OCCUPATIONAL DERMATOSES." In СОВРЕМЕННЫЕ ПРОБЛЕМЫ ЭКОЛОГИИ И ЗДОРОВЬЯ НАСЕЛЕНИЯ. ЭКОЛОГИЯ И ЗДОРОВЬЕ НАСЕЛЕНИЯ. Иркутский научный центр хирургии и травматологии, 2023. http://dx.doi.org/10.12731/978-5-98277-383-8-art12.

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The search for new modern methods of prevention and treatment of skin diseases remains relevant today. The aim is to evaluate the effectiveness of ozone therapy in the treatment of occupational allergodermatoses of chemical etiology. Materials and methods. Two groups of patients with occupational allergodermatoses (78 people) were examined and treated. Group 1 received only traditional treatment, in group 2 ozone therapy was added to the treatment complex. Immunological studies were performed using standard methods. Results. The use of ozone therapy in patients with allergodermatoses had a pos

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Santos, DRP, CE Reis, IO Moura, BO Barreto, CM Araujo, and LFA Nery. "LEUCEMIA LINFOBLÁSTICA AGUDA NA INFÂNCIA: RELATO DE CASO E ANÁLISE CLÍNICA DE UM PACIENTE ATENDIDO EM UM LABORATÓRIO DE ANÁLISES CLÍNICAS EM UBERABA, MINAS GERAIS." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.7679.

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Objetivo: A leucemia linfoblástica aguda (LLA) trata-se de um grupo de desordens clonais provenientes da célula hematopoiética imatura linfoide que sofreu alteração genética e se tornou neoplásica. Ela é a leucemia mais comum na infância e representa apenas 1/5 das leucemias do adulto. Na LLA, o crescimento rápido e desordenado das células interfere na produção de todas as células sanguíneas. Sua evolução é bastante rápida, tornando fundamental que o diagnóstico seja precoce e o tratamento se inicie o quanto antes. O objetivo deste estudo é relatar o caso de uma criança com LLA. Método: Os dad

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Reports on the topic "CD8"

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ภู่สุนทรธรรม, รสมา, พินิจ ภู่สุนทรธรรม, เดชฤทธิ์ นิลอุบล та ชาญณรงค์ รอดคำ. การศึกษาบทบาทของระดับภูมิคุ้มกันของร่างกายต่อการติดเชื้อบาร์โทเนลล่าในแมวป่วยด้วยโรคภูมิคุ้มกันบกพร่อง. จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.84.

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ทำการศึกษาถึงความชุกของการติดเชื้อ Bartonella spp. ในแมวปกติและแมวป่วยด้วยโรคภูมิคุ้มกันบกพร่อง ที่มารับการรักษา ณ โรงพยาบาลสัตว์เล็ก คณะสัตวแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย ในปี พ.ศ. 2561 พบว่ามีความชุกเท่ากับ 16.67% เมื่อทำการศึกษาถึงชนิดของการติดเชื้อ Bartonella spp. ด้วยวิธี PCR ในแมวที่เข้ามารับการฉีดวัคซีนป้องกันโรค และแมวป่วยด้วยโรคภูมิคุ้มกันบกพร่อง พบว่าเป็นเชื้อ Bartonella henselae ทั้งหมด ตรวจพบการติดเชื้อในแมวจำนวน 15 ตัวจากแมวที่ทำการศึกษาทั้งสิ้น 90 ตัว แมวส่วนใหญ่ที่ตรวจพบการติดเชื้อ Bartonella henselae ในการศึกษาครั้งนี้ เป็นแมวปกติที่แข็งแรงและไม่มีประวัติการเจ็บป่วยถึง 11 ตัว

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Palaga, Tanapat, Nattiya Hirankarn, and Hathaipat Phuwapirom. Level of IL-17 in Thai SLE patients. Chulalongkorn University, 2009. https://doi.org/10.58837/chula.res.2009.30.

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Systemic Lupus Erythematosus (SLE) is an autoimmune disorder which affects various systems. Currently, the etiology of this disease has not been fully elucidated. One of potential causes which may play an important role is the defects in cytokine network and the functions of T lymphocytes. Previously, it was reported that SLE patients showed elevated elevated level of various cytokines such as IL-1β IL-6 IL-23. The aim of this study was to investigate the level of cytokine IL-17 which could be produced by various cell types including T lymphocytes CD4+ T lymphocytes mainly producing IL-17 form

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แก้วกิติณรงค์, กมล, та นิพนธ์ อุดมสันติสุข. บทบาทของ MAIT cells ในการควบคุมการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2016. https://doi.org/10.58837/chula.res.2016.28.

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วัณโรค (Tuberculosis) เป็นสาเหตุหลักของการเสียชีวิตจากโรคติดเชื้อของประชากรทั่วโลก (1) วัณโรคเกิดจากการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis ภูมิต้านทานของร่างกายที่มีต่อเชื้อ Mycobacterium tuberculosis ประกอบด้วยเซลล์จากส่วนของ innate immunity และ adaptive immunity ในส่วนของ adaptive immunity กลุ่มของ T cells ที่มีส่วนสำคัญ ได้แก่ ทั้ง conventional T cells (ทั้ง CD8+ และ CD4+) และ non-conventional T cells (MAIT, NKT, CD1-restricted T cells) (2) MAIT (Mucosal-associated invariant T) cells จัดอยู่ในกลุ่มของ non-conventional T cells ที่พบได้ปริมาณมากตามเยื่อบุของร่างกาย รวมถึงปอด (3) นอกจ

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Knutson, Keith L. CD8 T Cells and Immunoediting of Breast Cancer. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada624685.

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ภู่สุนทรธรรม, รสมา, สัมพันธ์ วงศ์เสรีพิพัฒนา, คณิศักดิ์ อรวีระกุล та ін. การศึกษาผลของการใช้สารสกัดสมุนไพรเม่า ต่ออาการทางคลินิก ระดับอัตราส่วน CD4:CD8 และ Virus Load ในเลือดของแมวที่ติดเชื้อโรคภูมิคุ้มกันบกพร่อง : A Placebo-controlled Double-blind Study. จุฬาลงกรณ์มหาวิทยาลัย, 2008. https://doi.org/10.58837/chula.res.2008.80.

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Banai, Menachem, and Gary Splitter. Molecular Characterization and Function of Brucella Immunodominant Proteins. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568100.bard.

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The BARD project was a continuation of a previous BARD funded research project. It was aimed at characterization of the 12kDa immunodominant protein and subsequently the cloning and expression of the gene in E. coli. Additional immunodominant proteins were sought among genomic B. abortus expression library clones using T-lymphocyte proliferation assay as a screening method. The 12kDa protein was identified as the L7/L12 ribosomal protein demonstrating in the first time the role a structural protein may play in the development of the host's immunity against the organism. The gene was cloned fro

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รักษ์รุ่งธรรม, เกียรติ, สุปราณี บูรณประดิษฐ์กุล, ชุติธร เกตุลอย та เอกชัย พรหมเพชร. การศึกษาบทบาทของ subset T cells และ T follicular helper cells (TFH) ของ CD4+ T cells และ CD8+ T cells ในผู้ป่วยโรคไข้เลือดออกในคนไทย. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.19.

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Bullock, Timothy N., and Kimberly A. Kelly. Functional Proteomics to Identify Moderators of CD8+ T-Cell Function in Melanoma. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada599199.

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Bullock, Timothy N., and Kimberly A. Kelly. Functional Proteomics to Identify Moderators of CD8+ T-Cell Function in Melanoma. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada618873.

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Bullock, Timothy N., and Kimberly A. Kelly. Functional Proteomics to Identify Moderators of CD8+ T Cell Function in Melanoma. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada625202.

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