Relevant bibliographies by topics / CDAU

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  5. Conference papers
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Academic literature on the topic 'CDAU'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "CDAU"

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Espinosa-Chaurand, Luis Daniel, Antonio Silva-Loera, Zaúl García-Esquivel, and Lus Mercedes López-Acuña. "Using shrimp head meal as protein replacement of fish meal in diets for juvenile of Totoaba macdonaldi (Gilbert, 1890)." Latin American Journal of Aquatic Research 43, no. 3 (2017): 457–65. http://dx.doi.org/10.3856/vol43-issue3-fulltext-7.

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In diets for Totoaba macdonaldi juveniles (26.3 ± 4.7g y 13.6 ± 1cm) the partial replacement of fishmeal protein (HP) with shrimp head meal (HCC) was evaluated, over their growth, survival, fed conversion (FCA) and chemical composition of tissues and the apparent digestibility coefficient of dry matter (CDA), protein (CDAP) and lipids (CDAL) of these diets. The HCC used were from the whole shrimp head sun dried (F) and smashed shrimp head dehydrated in a hot air drier. Diets were isoproteic (55.5% crude protein), isolipídic (15% lipids) and isocaloric (4.6 kcal g-1) replacing 0% (control diet; DC), 15% (F15 and M15) and 30% (F30 and M30) of the HP protein by the HCC. At 57th day, survival with HCC (99.44 ± 1.92%) was higher than DC (88.89 ± 3.85 %). The gain weight, weight specific growth (TCE) and total intake were not statistically different (P > 0.05) between organisms feed with HCC, however with the M30 diet the TCE had higher average (0.99 ± 0.06) and growth (19.82 ± 1.64 g/fish). With diet M30 the FCA was the best significantly (1.61 ± 0.13) and the higher CDA (66.18 ± 1.28), CDAP (86.51 ± 0.53) and CDAL (72.29 ± 1.10). It concluded that replaced protein of HP by HCC in diet for juvenile totoaba improved the growth and CDAs, yielding better results with the inclusion of macerated HCC with a replacement level of 30%.
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Agrigento, Veronica, Sclafani Serena, Paolo Rigano, et al. "Congenital Dyserythropoietic Anemias: Molecular Diagnosis and Diagnostic Approach in a Cohort of Italian Patients." Blood 126, no. 23 (2015): 2142. http://dx.doi.org/10.1182/blood.v126.23.2142.2142.

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Abstract Introduction. Congenital dyserythropoietic anemias (CDAs) are hereditary rare erythropoietic disorder characterized by distinct morphological abnormalities of the bone marrow cells, ineffective erythropoiesis and systemic iron overload. This conditions is characterized by a maturation arrest during erythropoiesis with a reduced reticulocyte production in contrast with erythroid hyperplasia in bone marrow. Three types of CDA are known: types 1, 2 and 3.The identification of their causative genes provided evidence that these conditions have different molecular mechanisms that induce abnormal cell maturation and division. We describe the clinical and laboratory manifestations, the diagnosis procedure, the therapeutic approaches and the clinical phenotype in some cases of congenital dyserythropoietic anemia (CDAs) in Italian patients. The molecular analysis allow us to identify several genetic variants some of which have never been described previously. This report highlights the importance of recognizing CDAI even in countries where thalassemia is common. Among the different tools genetic study of CDA-related genes remains the main approach for pursuing the right diagnosis. Methods. Peripheral blood samples from 100 normal adults and 20 patients with different types of anemia were collected. Blood samples were analyzed by EMA binding test and by polyacrylamide gel electrophoresis in presence of sodium dodecyl sulphate ( SDS-PAGE). SDS PAGE was carried out in a 3.5-17% exponential gradient gel in Fairbanks buffer Genomic DNA was extracted from mononuclear cells of peripheral blood samples, by using a phenol-chloroform method. Polymerase chain reaction (PCR) products were sequenced directly using Big-Dye terminator 3.1 cycle sequencing kit and run on ABI PRISM 3130 DNA analyzer. The bone marrow of all patients was analysed with light or electron microscopy. The diagnosis of CDAs was based on the presence of mild to moderate anemia ineffective erythropoiesis and bone marrow erythroblasts morphological abnormalities. SEC23B, CDAN1, KLF1, BCL11A gene sequencing analysis was performed to highlight the presence of nucleotide variations and their relationship with the clinical presentation. Results and Discussion. We collected blood samples from 20 Italian patients with suspect of CDAs and 100 samples belonging to the healthy control subjects.None mutation in the genes analyzed was found in the samples controls.We identified SEC 23 B mutations in 4 out of 20 patients analysed. In two patients with suspect of CDAII we found two nucleotide variations; SDS PAGE in these patients identified the presence of abnormal band 3 and the EMA binding test resulted pathologic. Bone marrow (BM) light microscopy revealed more than 10% mature binucleated erythroblasts. In the patients suspected of CDA1, several gene variants were found in the CDAN1 gene, some described in the literature as mutations or polymorphisms, others of uncertain significance. In a patient diagnosed with CDA1 two novel mutations was found. EMA binding test resulted normal in all patients with CDA1. Light microscopy of the BM of CDA1 patients showed erythroid hyperplasia, presence of internuclear bridges between intermediate erythroblasts and characteristic pattern of spongy "swiss cheese" hetrochromatin in electron microscopy. None KLF1 and BCL11A mutations correlated with atypical CDAs was identified. In this last patients the EMA binding test resulted normal. CDAs are rare clinical hereditary disorders whose correct diagnosis is often delayed to adolescence or adulthood, when significant iron overload and end organ damage may have been occurred. Patients are often misdiagnosed with other congenital haemolytic anaemias. Inaccurate diagnosis can lead to inappropriate therapies, such as iron supplements, aggressive transfusion or splenectomy. However even if the gold standard for the CDAs diagnosis is the electronic microscopy, the identification of the mutated genes involved in the majority of CDAs patients made in recent years has improved the possibility of detecting these diseases. Disclosures No relevant conflicts of interest to declare.
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Rismondo, Jeanine, Johannes Gibhardt, Jonathan Rosenberg, Volkhard Kaever, Sven Halbedel, and Fabian M. Commichau. "Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes." Journal of Bacteriology 198, no. 3 (2015): 416–26. http://dx.doi.org/10.1128/jb.00845-15.

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ABSTRACTCyclic diadenylate monophosphate (c-di-AMP) is a second messenger utilized by diverse bacteria. In many species, including the Gram-positive human pathogenListeria monocytogenes, c-di-AMP is essential for growth. Here we show that the single diadenylate cyclase ofL. monocytogenes, CdaA, is an integral membrane protein that interacts with its potential regulatory protein, CdaR, via the transmembrane protein domain. The presence of the CdaR protein is not required for the membrane localization and abundance of CdaA. We have also found that CdaR negatively influences CdaA activity inL. monocytogenesand that the role of CdaR is most evident at a high growth temperature. Interestingly, acdaRmutant strain is less susceptible to lysozyme. Moreover, CdaA contributes to cell division, and cells depleted of CdaA are prone to lysis. The observation that the growth defect of a CdaA depletion strain can be partially restored by increasing the osmolarity of the growth medium suggests that c-di-AMP is important for maintaining the integrity of the protective cell envelope. Overall, this work provides new insights into the relationship between CdaA and CdaR.IMPORTANCECyclic diadenylate monophosphate (c-di-AMP) is a recently identified second messenger that is utilized by the Gram-positive human pathogenListeria monocytogenes. Here we show that the single diadenylate cyclase ofL. monocytogenes, CdaA, is an integral membrane protein that interacts with CdaR, its potential regulatory protein. We show that CdaR is not required for membrane localization or abundance of the diadenylate cyclase, but modulates its activity. Moreover, CdaA seems to contribute to cell division. Overall, this work provides new insights into the relationship between CdaA and CdaR and their involvement in cell growth.
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Holland, Stephen J., Lesley M. Berghuis, Justin J. King, et al. "Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys." Proceedings of the National Academy of Sciences 115, no. 14 (2018): E3211—E3220. http://dx.doi.org/10.1073/pnas.1720871115.

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Cytidine deaminases of the AID/APOBEC family catalyze C-to-U nucleotide transitions in mRNA or DNA. Members of the APOBEC3 branch are involved in antiviral defense, whereas AID contributes to diversification of antibody repertoires in jawed vertebrates via somatic hypermutation, gene conversion, and class switch recombination. In the extant jawless vertebrate, the lamprey, two members of the AID/APOBEC family are implicated in the generation of somatic diversity of the variable lymphocyte receptors (VLRs). Expression studies linked CDA1 and CDA2 genes to the assembly of VLRA/C genes in T-like cells and the VLRB genes in B-like cells, respectively. Here, we identify and characterize several CDA1-like genes in the larvae of different lamprey species and demonstrate that these encode active cytidine deaminases. Structural comparisons of the CDA1 variants highlighted substantial differences in surface charge; this observation is supported by our finding that the enzymes require different conditions and substrates for optimal activity in vitro. Strikingly, we also found that the number of CDA-like genes present in individuals of the same species is variable. Nevertheless, irrespective of the number of different CDA1-like genes present, all lamprey larvae have at least one functional CDA1-related gene encoding an enzyme with predicted structural and chemical features generally comparable to jawed vertebrate AID. Our findings suggest that, similar to APOBEC3 branch expansion in jawed vertebrates, the AID/APOBEC family has undergone substantial diversification in lamprey, possibly indicative of multiple distinct biological roles.
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Sherraden, Michael, Margaret Clancy, Yunju Nam, et al. "Universal and Progressive Child Development Accounts: A Policy Innovation to Reduce Educational Disparity." Urban Education 53, no. 6 (2016): 806–33. http://dx.doi.org/10.1177/0042085916682573.

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Child Development Accounts (CDAs) aim to increase college completion rates among disadvantaged youth by helping youth see themselves as “college bound.” This article summarizes findings about the implementation and impacts of universal, progressive CDAs, with emphasis on outcomes for disadvantaged children. Data come from a large randomized experiment. CDAs positively affect ownership of college savings accounts and assets, educational expectations, and other indicators of well-being. Disadvantaged children especially benefit from having a CDA. If CDAs prove to have long-term effects on educational expectations, college preparation, and educational achievement, then a national universal, progressive CDA could reduce educational disparities.
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Fereli, Fernanda, Antonio Ferriani Branco, Clóves Cabreira Jobim, Sabrina Marcantonio Coneglian, Fernanda Granzotto, and Julio Cezar Barreto. "Monensina sódica e Saccharomyces cerevisiae em dietas para bovinos: fermentação ruminal, digestibilidade dos nutrientes e eficiência de síntese microbiana." Revista Brasileira de Zootecnia 39, no. 1 (2010): 183–90. http://dx.doi.org/10.1590/s1516-35982010000100024.

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Avaliaram-se os efeitos do uso de monensina sódica, Saccharomyces cerevisiae e da mistura de ambos na dieta de bovinos sobre o pH e a concentração de amônia no rúmen, a digestibilidade aparente parcial e total dos nutrientes e a síntese de proteína microbiana no rúmen. Foram utilizados quatro bovinos da raça Holandesa Preto e Branco, castrados, com 320 kg de peso vivo, e canulados no rúmen. O delineamento experimental utilizado foi o quadrado latino 4 × 4, e os tratamentos consistiram de doses diárias de: 200 mg de monensina sódica (100I); 100 mg monensina sódica + 2,5 g Saccharomyces cerevisiae (50IP); 200 mg de monensina sódica + 5 g Saccharomyces cerevisiae (100IP); e 5 g Saccharomyces cerevisiae (100P), fornecidos diariamente pela cânula ruminal. A dieta contendo 100I promoveu menor digestão intestinal e total da matéria seca (MS), maior digestão intestinal da fibra em detergente neutro (FDN) e do extrato etéreo (EE), maior digestão total da proteína bruta (PB) e do EE e maior coeficiente de digestibilidade aparente ruminal (CDAR) e total (CDAT) da PB. A dieta contendo 100P resultou em menor digestão ruminal da PB, maior digestão ruminal da FDN, maior digestão intestinal da matéria orgânica (MO), da PB e dos carboidratos não-fibrosos (CNF), maior digestão total da matéria orgânica e do extrato etéreo, maior CDAR da FDN, maior coeficiente de digestibilidade intestinal (CDAI) da MO e dos CNF e maior CDAT da MO. A dieta 100P promoveu maior fluxo omasal de nitrogênio bacteriano e maior eficiência microbiana aparente e verdadeira. A dieta com 5 g/dia de Saccharomyces cerevisiae apresentou valor de NDT superior ao das outras dietas. As dietas não diferem quanto ao pH e à concentração de amônia no rúmen.
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Weng, Peter J., Yang Gao, Mark T. Gregory, Pengcheng Wang, Yinsheng Wang та Wei Yang. "Bypassing a 8,5′-cyclo-2′-deoxyadenosine lesion by human DNA polymerase η at atomic resolution". Proceedings of the National Academy of Sciences 115, № 42 (2018): 10660–65. http://dx.doi.org/10.1073/pnas.1812856115.

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Oxidatively induced DNA lesions 8,5′-cyclopurine-2′-deoxynucleosides (cdPus) are prevalent and cytotoxic by impeding DNA replication and transcription. Both the 5′R- and 5′S-diastereomers of cdPu can be removed by nucleotide excision repair; however, the 5′S-cdPu is more resistant to repair than the 5′R counterpart. Here, we report the crystal structures of human polymerase (Pol) η bypassing 5′S-8,5′-cyclo-2′-deoxyadenosine (cdA) in insertion and the following two extension steps. The cdA-containing DNA structures vary in response to the protein environment. Supported by the “molecular splint” of Pol η, the structure of 5′S-cdA at 1.75-Å resolution reveals that the backbone is pinched toward the minor groove and the adenine base is tilted. In the templating position, the cdA takes up the extra space usually reserved for the thymine dimer, and dTTP is efficiently incorporated by Pol η in the presence of Mn2+. Rigid distortions of the DNA duplex by cdA, however, prevent normal base pairing and hinder immediate primer extension by Pol η. Our results provide structural insights into the strong replication blockage effect and the mutagenic property of the cdPu lesions in cells.
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Niss, Omar, Robert B. Lorsbach, David K. Buchbinder, et al. "Congenital Dyserythropoietic Anemia Type I Due to Biallelic CDAN1 mutations: Report from the Congenital Dyserythropoietic Anemia Registry (CDAR)." Blood 134, Supplement_1 (2019): 3521. http://dx.doi.org/10.1182/blood-2019-128975.

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Congenital dyserythropoietic anemias (CDA) are rare hereditary diseases of abnormal erythropoiesis. The CDA Registry of North America (CDAR) (NCT02964494) was opened in 2016 to investigate the natural history and molecular biology of CDA. CDA type I (CDA-I) is a recessive form of CDA characterized by macrocytic anemia, hemolysis with inadequate reticulocytosis, and iron overload. The bone marrow shows binucleated erythroblasts with chromatin bridges by light microscopy and spongy heterochromatin in erythroblasts by electron microscopy. The phenotypic heterogeneity in presentation and course of CDA-I is remarkable. Most CDA-I cases are caused by biallelic mutations in CDAN1or C15orf41, and 10-20% do not have an identifiable mutation. Non-hematological features, especially skeletal features, were historically reported in 10-20% of patients (Wickramasinghe, 1998). Due to the rarity of CDA-I and its clinical overlap with several disorders, the diagnosis is often missed or delayed by up to 17 yrs (median) (Roy, 2019). We describe in this study the characteristics and clinical course of CDA-I patients due to CDAN1 mutations enrolled in CDAR. Patients with a phenotypic diagnosis of CDA and their family members were enrolled in CDAR. Clinical and demographic data were gathered from participants at study entry and updated periodically thereafter. Participants elect to give blood, bone marrow, and DNA samples to the biorepository associated with CDAR. Participants with a phenotypic diagnosis of CDA-I and confirmed mutations in CDAN1 were included in this study. Six participants had a diagnosis of CDA-I due to biallelic CDAN1 mutations, comprising 18% (6/33) of affected CDAR participants. CDAN1 mutations were found in 75% of cases diagnosed phenotypically as CDA-I. All six participants presented early in life with a variable degree of non-immune hemolysis, and the diagnosis was confirmed within a median of 2 years from presentation. The characteristics of participants are summarized in table 1. Two had family history of stillbirth or fetal demise in older siblings due to hydrops fetalis. One participant presented prenatally with fetal anemia and started intrauterine transfusions at 24 weeks of gestation; 2 presented with severe anemia and signs of hydrops, pulmonary hypertension, transaminitis, severe hyperbilirubinemia, and thrombocytopenia at birth; and 3 presented with neonatal jaundice and moderate anemia. All participants required blood transfusions in the neonatal period. Three had spontaneous improvement and did not require transfusions after the first year of life. One remained transfusion-dependent at last follow up at the age of 4 yrs. One became transfusion-independent after starting interferon-alpha at 1 yr of age and did not need further transfusions even after discontinuation at 3 yrs of age. One had splenectomy at 11 y.o because he was misdiagnosed to have a membrane disorder but presented in adulthood with hemolytic anemia and pulmonary hypertension and was diagnosed at that time with CDA-I by genetic sequencing. All participants had one or more non-hematological manifestations, including hypertrophic skin folds, onychocryptosis, curved toenails, syndactyly, café-au-lait spots, macrocephaly, spinal fusion, scoliosis, and short stature. One participant suffered a thalamic stroke in the postnatal period, 2 had transient neonatal pulmonary hypertension in the setting of severe anemia, and one had pulmonary hypertension post-splenectomy in adulthood. Ferritin was high in all participants at last follow up, and 4 received chelation therapy. In summary, mutations in CDAN1 are the most common identified mutations in CDAR. CDA-I causes early-onset macrocytic anemia, which may present prenatally, with variable severity of hemolysis ranging from hydrops to mild neonatal jaundice and anemia. Non-hematological manifestations, mainly skeletal, nail and skin abnormalities are more common in CDA-I than previously reported, and their presence in infants with unexplained anemia should raise suspicion for the diagnosis. The availability of molecular testing has significantly accelerated the diagnosis. Management of patients with CDA-I requires multidisciplinary approach from an early age to improve outcome. Collaboration between clinicians, scientists, patients, and families is needed to advance the understanding and treatment of this rare disease. Disclosures Chonat: Alexion: Other: advisory board; Agios Pharmaceuticals, Inc.: Other: advisory board. Kalfa:Agios: Other: local PI of clinical research trial; FORMA: Other: sponsored research agreement.
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Emberesh, Myesa, Katie Giger Seu, Sana Emberesh, et al. "Peroxiredoxin II (PRDX2) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia." Blood 132, Supplement 1 (2018): 3605. http://dx.doi.org/10.1182/blood-2018-99-120056.

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Abstract CDAR (ClinicalTrials.gov Identifier: NCT02964494), a registry for patients with Congenital Dyserythropoietic Anemia (CDA) in North America, has been created with the goal to provide a longitudinal database and associated biorepository to facilitate natural history studies and research on the molecular pathways involved in the pathogenesis of CDAs. A 1 y.o. female patient with non-immune hemolytic anemia with suboptimal reticulocytosis, requiring frequent transfusions, and with the pathologic diagnosis of CDA was enrolled in CDAR. Her father had a similar phenotypical presentation in early childhood and underwent splenectomy at 3 years of age. Since then, he has rarely required transfusions but he continues to have a mild anemia at baseline with characteristics of hemolysis and with suboptimal reticulocytosis; at the time of enrollment, he had hemoglobin of 9.3 g/dL with absolute reticulocyte count of 115 x 106 cells/µl. Next Generation sequencing and deletion/duplication assay for the known CDA-associated genes (CDAN1, C15ORF41, SEC23B, KIF23, GATA1) identified no mutations. Whole-exome sequencing for the patient and her parents (family-trio design) revealed a novel PRDX2 missense variant (c.154C>T; p.Pro52Ser) present in heterozygous state in both proband and her father; no mutation in this gene was present in the asymptomatic mother. In silico prediction programs suggest that this variant is probably damaging and deleterious, causing a non-conservative substitution of a phylogenetically highly-conserved amino acid (down to Baker's yeast), and located in an enzymatically active protein domain, adjacent to the active Cys51, with the potential to change its conformation. Peroxiredoxin II is highly expressed during terminal erythropoiesis and is one of the most abundant proteins after hemoglobin in erythroblasts and mature erythrocytes. It is an antioxidant enzyme that reduces the reactive oxygen species (ROS), like hydrogen peroxide and alkyl hydroperoxides readily produced within the erythroid cells due to the presence of heme iron and oxygen. In addition, PRDX2 has been implicated in intracellular signaling, cellular proliferation and differentiation, and as a regulator of iron homeostasis. PRDX2-/- mice were found to have hemolytic anemia with evidence of oxidative damage of the erythrocyte proteins resulting to decreased red blood cell (RBC) survival. The aim of this work is to validate the pathogenetic role of the PRDX2 variant found in this family as the molecular cause of this dominantly-inherited CDA and further investigate the role of PRDX2 in human terminal erythropoiesis. Central review of the patient's bone marrow aspirate and biopsy slides, according to the CDAR protocol, revealed erythroid hyperplasia with dyserythropoiesis, including megaloblastoid changes, nuclear lobation and fragmentation, and binucleated erythroblasts (less than 10%), compatible with atypical CDA. There were rare erythroids with cytoplasmic bridging but no nuclear bridges. Review of the peripheral blood smear showed significant poikilocytosis, mild polychromasia, and the presence of blister and ghost cells reminiscent of G6PD deficiency, pointing to RBC damage by oxidative stress. Induced pluripotent stem cells (iPSCs) and EBV-immortalized lymphocytes were generated from the patients' peripheral blood mononuclear cells after informed consent per CDAR protocol, to allow further in vitro studies of the peroxiredoxin II-deficiency. Flow cytometry confirmed significantly increased ROS in the patients' derived versus control EBV-immortalized lymphocytes as well as in the reticulocytes and mature erythrocytes of the proband and her father, indicating that their PRDX2 variant is causing loss-of-function of the enzyme and increased oxidative stress. Further work is ongoing to explore the mechanisms of pathogenicity of peroxiredoxin II deficiency towards human dyserythropoiesis and decreased erythrocyte lifespan. To our knowledge, this is the first case of anemia described in humans associated with PRDX2 mutation implicating this gene as a novel candidate gene for atypical, dominantly-inherited CDA. Disclosures No relevant conflicts of interest to declare.
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Micklefield, Jason. "Biosynthesis and biosynthetic engineering of calcium-dependent lipopeptide antibiotics." Pure and Applied Chemistry 81, no. 6 (2009): 1065–74. http://dx.doi.org/10.1351/pac-con-08-08-29.

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Biosynthetic engineering involves the reprogramming of genes that are involved in the biosynthesis of natural products to generate new "non-natural" products, which might otherwise not exist in nature. Potentially this approach can be used to provide large numbers of secondary metabolites variants, with altered biological activities, many of which are too complex for effective total synthesis. Recently we have been investigating the biosynthesis of the calcium-dependent antibiotics (CDAs) which are members of the therapeutically relevant class of acidic lipopeptide antibiotics. CDAs are assembled by nonribosomal peptide synthetase (NRPS) enzymes. These large modular assembly-line enzymes process intermediates that are covalently tethered to peptidyl carrier protein (PCP) domain bonds bonds, which makes them particularly amenable to reprogramming. The CDA producer, Streptomyces coelicolor, is also a genetically tractable model organism which makes CDA an ideal template for biosynthetic engineering. To this end we have elucidated many of the key steps in CDA biosynthesis and utilized this information to develop methods that have enabled the engineered biosynthesis of wide range of CDA-type lipopeptides.
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Dissertations / Theses on the topic "CDAU"

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Bedgar, Kenda J., and Anthony J. Cullison. "FLIGHT TEST INSTRUMENTATION FOR THE ADVANCED HAWKEYE LOADS RISK REDUCTION PROJECT." International Foundation for Telemetering, 2005. http://hdl.handle.net/10150/605029.

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ITC/USA 2005 Conference Proceedings / The Forty-First Annual International Telemetering Conference and Technical Exhibition / October 24-27, 2005 / Riviera Hotel & Convention Center, Las Vegas, Nevada<br>This paper is about the installation of the instrumentation system and the strain gages on an E-2C Hawkeye for the Advanced Hawkeye Loads Risk Reduction project. Background information on why this project came about will be given. Explanations on why the existing instrumentation system was modified to the current system will be presented. Anthony Cullison (co-author of this paper) will explain the installation of the strain gages.
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Hayes, Angela Elizabeth. "Production of the calcium-dependent antibiotic (CDA) by Streptromyces coelicolor and Streptomyces lividans : molecular biology of cdaR and other genes from the cda cluster." Thesis, University of Manchester, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506567.

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The calcium-dependent antibiotic (CDA) is a non-ribosomally synthesised lipopeptide produced by Streptomyces coelicolor A3(2). The cda biosynthesis gene cluster occupies approximately 83 kb at the 10 o'clock region of the chromosome. A gene encoding a positive regulator of CDA production, designated cdaR, had been previously identified. Sequence similarly suggests that CdaR is a member of the Streptomyces antibiotic regulatory protein (SARP) family. CdaR is predicted to be 638 amino acid residues in size with a putative ATP/GTP-binding site motif A located in its C-terminal region. Mapping of the transcription start point of cdaR found that it possesses an unusually long untranslated leader sequence of 358 nt. cdaR transcripts were easily detectable at the earliest time point examined (24 h) and decreased over time. A 0.75 kb in-frame deletion in cdaR abolished CDA production. Nuclease protection experiments, using RNA isolated from a S. coelicolor cdaR deletion mutant, indicated that CdaR is required for transcription of some of the genes within the cda cluster, including itself. His6-tagged CdaR was produced in E. coli. Preliminary evidence from mobility shift assays suggested that CdaR binds directly to the 5' end of cdaR and also possibly to the promoter region of cdaPSI (peptide synthetase 1). Unexpectedly, introducing multiple copies of cdaR (approximately 50 copies/chromosome) into S. coelicolor 2377 and MT1110 did not detectably increase CDA production. Correspondingly cdaR transcripts only increased by ~ 30% in S. coelicolor MT1110 containing multiple copies of cdaR; this result suggests that transcription of cdaR is very tightly regulated.
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Kulkarni, Dattatraya H. "CDA, computation decomposition and alignment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0008/NQ27983.pdf.

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Kirik, Mustafa Sancay. "Design, Analysis, And Implementation Of Circular Disk - Annular Ring (cdar) Antenna." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12609156/index.pdf.

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In satellite applications, a circularly polarized satellite antenna is desirable with a pattern that results in constant received power while the distance between the transmitter and the receiver is changing. The Circular Disk - Annular Ring (CDAR) antenna satisfies these requirements along with other requirements for the satellite antenna. The CDAR antenna is a combination of a Circular Disk and an Annular Ring patch antennas. In this thesis, a circularly polarized CDAR antenna that is fed from a single point is designed at the center frequency of 8.2 GHz. This antenna is investigated and optimized to ease the fabrication process. The design parameters are defined on this report and optimized by using an Electromagnetic Simulation software program. In order to verify the theoretical results, Circular Disk - Annular Ring Antenna is produced as a prototype. Measurements of antenna parameters, electromagnetic field and circuit properties are interpreted to show compliance with theoretical and simulation results. The values of deviation between theoretical and experimental results are also discussed.
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Neugebauer, John Henry Christopher. "Older and wiser? : a study of senior managers and age." Thesis, University of Bristol, 2010. http://hdl.handle.net/1983/03e8a8e5-cda4-4389-8f21-e605b9e43690.

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Taylor, B. D. "After constructivism." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:a09edf30-cdad-40a1-aa3e-03ce482a478c.

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This thesis examines the legacy and consequences of Constructivism in art, from the early days of the Russian avant-garde to recent times and today. The Introduction explains how the concept of faktura, first theorised around 1912 by David Burliuk and others, came to designate the material qualities rather than the subject-matter of art. Chapter 1: Towards A Constructive Ideal, traces the progress of faktura in the reliefs of V.Tatlin from 1913. The ancestry of faktura in the Eastern icon tradition is emphasised, where a close relation between sight and touch already suggested a new type of encounter between the viewer and the object of art. The chapter further examines the importance of faktura to Suprematism, and examines A.Rodchenko’s appeal to line as a rational element of construction and as a weapon against ‘composition’ in art. Chapter 2: Time and the Viewer presents evidence of the importance to artists in the period 1940-70 of the real-time encounter between viewer and the art-object, first in American and British ‘Constructionism’, and then in the Minimal art of Judd, Morris and others. The chapter ends with a discussion of temporality in relation to abstract paintings of Rothko and de Kooning. Chapter 3: Irregular Curves: Science and ‘The Organic’ reprises the minority Constructivism of Mikhail Matyushin and Pyotr Miturich that claimed organic structures were superior to technicist ones. Evidence is presented that the rectilinear grid was always subject to challenge, initially in the art of Emma Kunz, Jean Arp and other pre-war modernists but latterly among those for whom ‘field’ and ‘curvature’ became relevant formats after 1945. Particularly with the development of computing from the 1970s, new geometries based on iteration and scale-invariancy assumed major relevance to constructed art. Chapter 4: Constructivism Now presents evidence of the application of Constructivist principles in recent art, initially in Dan Flavin’s ‘monuments’ to Tatlin and others and subsequently in so-called Neo-Geo and Op art of the 1970s and 1980s. From that period on, albeit often in a register of irony and ‘serious play’, faktura in a Constructivist sense continued, and continues today, to define the relation between viewer and object of art.
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Focke, Sandra. ""Politik-Marketing" : die Marketing-Strategien der beiden großen Volksparteien (CDU, SPD) im Bundestagswahlkampf 2002 mit Schwerpunkt auf Materialien der CDU." Frankfurt, M. [u.a.] Lang, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&docl̲ibrary=BVB01&docn̲umber=016230761&linen̲umber=0001&funcc̲ode=DBR̲ECORDS&servicet̲ype=MEDIA.

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George, Stephen J. "Community of Inquiry Meets Critical Discourse Analysis (CDA): A CDA of Asynchronous Computer-Conference Discourse with Seminary Students in India." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1011816/.

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The purpose of this study was to better understand student learning in asynchronous computer-conference discourse (ASD) for non-native speakers of English in India through the Community of Inquiry (COI) framework. The study looked at ASD from an online course taught in the fall of 2015 to 25 students in a seminary in South India. All but one of the students were non-native speakers of English. The class consisted of 22 men and 3 women. Eight students spoke languages from the Dravidian family of languages (Malayalam, Tamil, Telegu and Kannada). Eight students were from the Northeastern states of Manipur, Nagaland and Tripura, where most languages are from the Sino-Tibetan family. Three students were native speakers of Indo-Aryan languages (Odiya and Assamese). Five students were from Myanmar representing several Sino-Tibetan languages. The COI is a framework used to understand learning in ASD, often used in online learning. To study the ASD of this group, critical discourse analysis (CDA) was used with the COI to capture the unique socio-cultural and linguistic conditions of this group. The study revealed that non-native speakers of English often reach the Exploration phase of learning but rarely show evidence of reaching the Resolution phase. This phenomenon was also observed in native English speakers as reported in the literature. Also, the structure of ASD showed that students took an examination approach to discussion shaped in part by their epistemology. This examination approach shaped how knowledge was constructed. CDA also showed that the discourse acquired an instructor-centered structure in which Resolution and Repair were initiated and finalized by the instructor. The study advances the COI framework by undergirding it with a theory of asynchronous discourse using critical discourse analysis and capturing cognitive, social and teaching presence phenomena for non-native speakers that were not observed through the traditional COI framework. These phenomena were driven by cultural, epistemological, and linguistic forces and require a rethinking of the COI for contexts outside of North America. The study also demonstrates that learning for non-native speakers in ASD is challenged by these very same forces. Therefore, design for online learning should account for these phenomena.
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Ellece, Sibonile Edith. "Gendered Marrige Discourses in Botawana : A CDA Approach." Thesis, Lancaster University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507051.

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Nakazone, Lucia Midori. "Implantação de reservatórios de detenção em conjuntos habitacionais: a experiência da CDHU." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/3/3147/tde-13042006-210759/.

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Novas medidas de controle das vazões excedentes surgiram nos últimos anos e buscam contornar as mudanças nos ciclos hidrológicos, imitando e mantendo as condições naturais existentes antes dos processos de urbanização. Uma dessas alternativas, conhecida genericamente pelo nome de reservatório de armazenamento, procura reter parte do escoamento superficial gerado durante as precipitações, para depois fazer sua devolução de forma lenta e gradual aos leitos dos córregos e rios, atenuando o pico dos hidrogramas e redistribuindo as vazões ao longo do tempo. Uma das variáveis desse reservatório de armazenamento, que permanece seco entre eventos chuvosos, é denominado de reservatório de detenção e constitui-se o objeto deste trabalho. Sua implantação e utilização são discutidas por meio das experiências da CDHU, através de estudos de casos reais, onde prova-se que a incorporação desse novo dispositivo de drenagem urbana é ainda um assunto polêmico, para o qual técnicos, governantes e população estão despreparados. É legítimo o anseio da sociedade por medidas sustentáveis e ambientalmente corretas, na qual os reservatórios de detenção se enquadram, porém sua implementação por força de medidas legais, muitas vezes, tem sido realizada de forma pouco conseqüente, sem planejamento e ponderação quanto às dificuldades e implicações dessa atitude. Denota-se também, a necessidade de avaliação da eficiência destes dispositivos e de normatização das formas de aplicação, dimensionamento, operação e manutenção. Além disso, é necessário a sensibilização, a conscientização e a educação em todos os níveis, pois existem paradigmas a serem quebrados e obstáculos a serem vencidos. Ao final do trabalho, sugere-se um pequeno roteiro com diretrizes gerais para incorporação dos reservatórios de detenção em novos empreendimentos, com o intuito de orientar e facilitar a utilização desses dispositivos, melhorando sua aceitação pela sociedade.<br>New stormwater control techniques have emerged during last years, trying to mimic and keep the natural conditions of hydrologic cycle. One of these measures, known as storage facility, detains part of the rainfall runoff to release it at controlled rates downstream, attenuating the hydrograph peak and redistributing the volume over a certain period of time. The focus of this report is the detention basin, a storage facility designed to empty out between runoff occurrences. Its insertion and use are discussed through CDHU experiences, based on real cases, where the results show that this new urban drainage control system is still a polemic issue, for what technicians, governments and population are unprepared. Society’s concerns about sustainable and environmentally correct measures, inside which detention pond is placed, are rightful, however its implementation in the course of legal procedures has been made carelessly, unplanned and without considerations of difficulties and impacts. In addition, evaluation of its performance along with regulation of using forms, dimensioning, operation and maintenance are also required. Moreover, sensitiveness, consciousness and education related to detention basin should be improved, since there are paradigms to be broken and obstacles to win. At the end of this report, it is suggested some guidelines to incorporate detention basins in new land development, not only to facilitate and instruct the use of this structure, but also to improve society’s acceptance.
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Books on the topic "CDAU"

1

Sondermann, Bernd. Parteienfamilie ohne Zusammenhalt?: Programmatische Gegenreden von CDU, CDA und Tories auf die neue Sozialdemokratie. Lang, 2006.

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Association, Colour Dimensions. CDA directory. Colour Dimensions Association, 1995.

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Schmid, Josef. Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5.

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Christlich-Demokratische Union Deutschlands (Germany : West). Organisationshandbuch der CDU. Dico-Soft, 1987.

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Schmidt, Ute. Zentrum oder CDU. VS Verlag für Sozialwissenschaften, 1987. http://dx.doi.org/10.1007/978-3-322-96998-9.

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Illinois. Dept. of Commerce and Economic Opportunity. Community Development Assistance Program: CDAP. Illinois Dept. of Commerce and Economic Opportunity, 2003.

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Cromme, Franz. Die Finanzen der CDU. Verlag Dr. Kosẗer, 2000.

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Greve, Uwe. Parteienkrise: CDU am Scheideweg. Ullstein, 1993.

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Hemmelmann, Petra. Der Kompass der CDU. Springer Fachmedien Wiesbaden, 2017. http://dx.doi.org/10.1007/978-3-658-18115-4.

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Neumann, Arijana. Die CDU auf Landesebene. VS Verlag für Sozialwissenschaften, 2012. http://dx.doi.org/10.1007/978-3-531-94270-4.

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Book chapters on the topic "CDAU"

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Krüger, Paul. "Für einen geordneten Einigungsprozeß — zur Arbeit der CDU/CDA-Fraktion." In Mandat für Deutsche Einheit. VS Verlag für Sozialwissenschaften, 2000. http://dx.doi.org/10.1007/978-3-322-93235-8_10.

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Schmid, Josef. "Einleitung." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_1.

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Schmid, Josef. "Historische und aktuelle soziopolitische Umweltkonstellationen." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_2.

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Schmid, Josef. "Die CDU in den Ländern." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_3.

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Schmid, Josef. "Föderative Organisationsmuster in der CDU." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_4.

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Schmid, Josef. "Politikfelder: Strukturen, Prozesse, Bestimmungsfaktoren." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_5.

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Schmid, Josef. "Die Komplexität der Gesamtpartei." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_6.

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Schmid, Josef. "Zusammenfassung und Schluss." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_7.

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Schmid, Josef. "Anhang." In Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5_8.

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Dilling, Matthias. "Die CDU." In Parteien und soziale Ungleichheit. Springer Fachmedien Wiesbaden, 2016. http://dx.doi.org/10.1007/978-3-658-10390-3_4.

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Conference papers on the topic "CDAU"

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Purushothaman, Yuvaraj, Hoon Choi, Narayan Yoganandan, Jamie Baisden, Deepak Rajasekaran, and Davidson Jebaseelan. "Biomechanical Study of Cervical Disc Arthroplasty Devices Using Finite Element Models." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24123.

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Abstract Various types and designs of artificial discs for cervical disc arthroplasty (CDA) have been introduced to overcome the disadvantages of the conventional anterior cervical discectomy and fusion (ACDF). The purpose of this study was to evaluate the effects of different CDA designs on the range of motion (ROM), intradiscal pressure (IDP), and facet force variables with different types of FDA-approved CDA devices under normal physiological loading conditions. A validated three-dimensional finite element model (FEM) of the intact cervical spinal column (C2-T1) was used in the present study. The intact spine model was modified and used for postoperative FE models simulating CDAs implanted at the C5-C6 intervertebral disc space. The normal surgical procedures were used in the simulations. The hybrid loading protocol (intact spine loading: 2 Nm) with a compressive follower force of 75 N was applied at the superior end of the spine. The inferior endplate of C7 vertebra was constrained in all directions. Flexion, extension, and lateral bending loading conditions were simulated in all models: intact spine and models with different CDA devices. At the index level, all CDAs except the Bryan disc showed an increase in motion, and the range of motions at the adjacent levels decreased in flexion, extension, and lateral bending modes. The largest increase in motion occurred during lateral bending. The Bryan disc reduced the segmental motion at the index level under flexion, extension, and lateral bending, and had compensatory increases in motion at the adjacent levels. The intradiscal pressure reduced at the adjacent levels with Mobi-C and Secure-C devices. The Bryan and Prestige LP devices showed increases in the intradiscal pressure at the adjacent levels due to the reduced index level motion (Bryan disc) and the metal-on-metal design (Prestige LP). The facet force increased at the index level in all CDAs, with the highest force with Mobi-C, and this was attributed to its unrestrained design. The facet force generally decreased at the adjacent levels with CDAs, except for the Bryan disc, due to reduced index level motion, and the Prestige LP in lateral bending, likely due to its metal-on-metal design. The present study demonstrates the influence of different CDA designs on the anterior and posterior loading patterns at the index and adjacent levels. In addition, the study validates key clinical observations: CDA procedure is contraindicated in cases of facet arthropathy; and CDA may be protective against adjacent segment degeneration.
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Guo, Liancheng, Koji Morita, Hirotaka Tagami, and Yoshiharu Tobita. "Validation of a 3D Hybrid CFD-DEM Method Based on a Self-Leveling Experiment." In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30618.

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The postulated core disruptive accidents (CDAs) are regarded as particular difficulties in the safety analysis of liquid-metal fast reactors (LMFRs). In the CDAs, core debris may settle on the core-support structure and form conic bed mounds. Heat convection and vaporization of coolant sodium will level the debris bed, which is named “self-leveling behavior” of debris bed. To reasonably simulate such transient behavior, as well as thermal-hydraulic phenomena occurring during a CDA, a comprehensive computational tool is needed. The SIMMER code is a successful computer code developed as an advanced tool for CDA analysis of LMFRs. It is a multi-velocity-field, multiphase, multicomponent, Eulerian, fluid dynamics code coupled with a fuel-pin model and a space- and energy-dependent neutron kinetics model. Until now, the code has been successfully applied to simulations of key thermal-hydraulic phenomena involved in CDAs as well as reactor safety assessment. However, strong interactions among rich solid particles as well as particle characteristics in multiphase flows were not taken into consideration for its fluid-dynamics models. Therefore, a hybrid computational method was developed by combining the discrete element method (DEM) with the multi-fluid models to reasonably simulate the particle behaviors, as well as the thermal-hydraulic phenomena of multiphase fluid flows. In this study, 3D numerical simulation of a simplified self-leveling experiment is performed using the hybrid method. Reasonable agreement between simulation results and corresponding experimental data demonstrated the validity of the present method in simulating the self-leveling behavior of debris bed.
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Stamnes, Bent. "Cdak." In ACM SIGGRAPH 2011 Computer Animation Festival. ACM Press, 2011. http://dx.doi.org/10.1145/2019001.2019017.

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Li, Qi, and Hao Chen. "CDAS." In ICSCA '19: 2019 8th International Conference on Software and Computer Applications. ACM, 2019. http://dx.doi.org/10.1145/3316615.3316691.

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Morita, Koji, Tatsuya Matsumoto, Ryo Akasaka, et al. "Advanced Modeling of Multicomponent Vaporization/Condensation Phenomena for a Reactor Safety Analysis Code SIMMER-III." In 10th International Conference on Nuclear Engineering. ASMEDC, 2002. http://dx.doi.org/10.1115/icone10-22229.

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It is believed that the numerical simulation of thermal-hydraulic phenomena of multiphase, multicomponent flows in a reactor core is essential to investigate core disruptive accidents (CDAs) of liquid-metal fast reactors. A new multicomponent vaporization/condensation (V/C) model was developed to provide a generalized model for a fast reactor safety analysis code SIMMER-III, which analyzes relatively short-time-scale phenomena relevant to accident sequences of CDAs. The model characterizes the V/C process associated with phase transition through heat-transfer and mass-diffusion limited models to follow the time evolution of the rector core under CDA conditions. The heat-transfer limited model describes the nonequilibrium phase-transition processes occurring at interfaces, while the mass-diffusion limited model is employed to represent effects of noncondensable gases and multicomponent mixture on V/C processes. Verification of the model and method employed in the multicomponent V/C model of SIMMER-III was performed successfully by analyzing two series of condensation experiments.
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Igarashi, Kai, Ryoji Onuki, Takaaki Sakai, Shinya Kato, Ken-ichi Matsuba, and Kenji Kamiyama. "Validation of Analysis Models on Relocation Behavior of Molten Core Materials in Sodium-Cooled Fast Reactors Based on the Melt Discharge Experiment." In 2020 International Conference on Nuclear Engineering collocated with the ASME 2020 Power Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icone2020-16440.

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Abstract In order to improve the safety of nuclear power plants, it is necessary to make sure measures against their severe accidents. Especially, in the case of a sodium-cooled fast reactor (SFR), there is a possibility of significant energy release due to formation of a large-scale molten fuel pool accompanied by re-criticality in the event of a core disruptive accident (CDA). It is important to ensure in-vessel retention that keeps and confines damaged core material in the reactor vessel even if the CDA occurs. CDA scenario initiated by Unprotected Loss Of Flow (ULOF), which is a typical cause of core damage, is generally categorized into four phases according to the progression of core-disruptive status, which are the initiating, early-discharge, material-relocation and heat-removal phases for the latest design in Japan. During the material-relocation phase, the molten core material flows down mainly through the control rod guide tube and is discharged into the inlet coolant plenum below the bottom of the core. The discharged molten core material collides with the bottom plate of the inlet plenum. Clarification of the accumulation behavior of molten core material with such a collision on the bottom plate is important to reduce uncertainties in the safety assessment of CDA. In present study, in order to make clear behavior of core melt materials during the CDAs of SFRs, analysis was conducted using the SIMMER-III code for a melt discharge simulation experiment [1] in which low-melting-point alloy was discharged into a shallow water pool. This report shows the validation results for the melt behavior by comparing with the experimental data.
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Guo, Liancheng, Koji Morita, Hirotaka Tagami, and Yoshiharu Tobita. "Numerical Simulation of Self-Leveling Behavior in Debris Bed by a Hybrid Method." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-15483.

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The postulated core disruptive accidents (CDAs) are regarded as particular difficulties in the safety analysis of liquid-metal fast reactors (LMFRs). In the CDAs, the self-leveling behavior of debris bed is a crucial issue to the relocation of molten core and heat-removal capability of the debris bed. The fast reactor safety analysis code, SIMMER-III, which is a 2D, multi-velocity-field, multiphase, multicomponent, Eulerian, fluid dynamics code coupled with a fuel-pin model and a space- and energy-dependent neutron kinetics model, was successfully applied to a series of CDA assessments. However, strong interactions among rich solid particles as well as particle characteristics in multiphase flows were not taken into consideration for fluid-dynamics models of SIMMER-III. In this article, a developed hybrid method, by coupling the discrete element method (DEM) with the multi-fluid model of SIMMER-III, is applied in the numerical simulation of self-leveling behavior in debris bed. In the coupling algorithm the motions of gas and liquid phases are solved by a time-factorization (time-splitting) method. For particles, contact forces among particles and interactions between particles and fluid phases are considered through DEM. The applicability of the method in such complicate three phase flow is validated by taking the simulation of a simplified self-leveling experiment in literature. Reasonable agreement between simulation results and corresponding experimental data shows that the present method could provide a promising means for the analysis of self-leveling behavior of debris bed in CDAs.
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Shirakawa, Noriyuki, Yasushi Uehara, Masanori Naitoh, Hidetoshi Okada, Yuichi Yamamoto, and Seiichi Koshizuka. "Next Generation Safety Analysis Methods for SFRs—(5) Structural Mechanics Models of COMPASS Code and Verification Analyses." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75532.

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A five-year research project started in FY2005 (Japanese Fiscal Year, hereafter) to develop a code based on the Moving Particle Semi-implicit (MPS) method for detailed analysis of core disruptive accidents (CDAs) in sodium-cooled fast reactors (SFRs). The code is named COMPASS (Computer Code with Moving Particle Semi-implicit for Reactor Safety Analysis). CDAs have been almost exclusively analyzed with SIMMER-III [2], which is a two-dimensional multi-component multi-phase Eulerian fluid-dynamics code, coupled with fuel pin model and neutronics model. The COMPASS has been developed to play a role complementary to SIMMER-III in temporal and spatial scale viewpoint; COMPASS for mesoscopic using a small window cut off from SIMMER-III for macroscopic. We presented the project’s outline and the verification analyses of elastic structural mechanics module of the COMPASS in ICONE16 [1]. The COMPASS solves physical phenomena in CDAs coupling fluid dynamics and structural dynamics with phase changes, that is vaporization/condensation and melting/ freezing. The phase changes are based on nonequilibrium heat transfer-limited model and all “phase change paths” considered in SIMMER-III are implemented [20]. In FY2007, the elastoplastic model including thermal expansion and fracture are formulated in terms of MPS method and implemented in the COMPASS, where the model adopts the von Mises type yield condition and the maximum principal stress as fracture condition. To cope with large computing time, “stiffness reduction approximation” was developed and successfully implemented in the COMPASS besides parallelization effort. Verification problems are set to be suitable for analyses of SCARABEE tests, EAGLE tests and hypothetical CDAs in real plants so that they are suggesting issues to be solved by improving the models and calculation algorithms. The main objective of SCARABEE-N in-pile tests was to study the consequences of a hypothetical total instantaneous blockage (TIB) at the entrance of a liquid-metal reactor subassembly at full power [21]. The main objectives of the EAGLE program consisting of in-pile tests using IGR (Impulse Graphite Reactor) and out-of-pile tests at NNC/RK are; 1) to demonstrate effectiveness of special design concepts to eliminate the re-criticality issue, and 2) to acquire basic information on early-phase relocation of molten-core materials toward cold regions surrounding the core, which would be applicable to various core design concepts [22, 23]. In this paper, the formulations and the results of functional verification of elastoplastic models in CDA conditions will be presented.
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Jung, Sungwon, and Jinwook Choi. "Generation of Level 3 CDA Document Using CDA Studio." In 2007 International Conference on Convergence Information Technology (ICCIT 2007). IEEE, 2007. http://dx.doi.org/10.1109/iccit.2007.248.

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Jung, Sungwon, and Jinwook Choi. "Generation of Level 3 CDA Document Using CDA Studio." In 2007 International Conference on Convergence Information Technology (ICCIT 2007). IEEE, 2007. http://dx.doi.org/10.1109/iccit.2007.4420445.

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Reports on the topic "CDAU"

1

Evans, W. CDAC Activity Report. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/883593.

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Trujillo, Gabrielle. FY20Q3 CDA. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1763582.

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Herriman, Jane E. CDAC Student Report: Summary of LLNL Internship. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1330134.

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Marlais, S. M. Development of a climate data analysis tool (CDAT). Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/641114.

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Williams, Dean N., and Claudio Silva. Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT). Office of Scientific and Technical Information (OSTI), 2013. http://dx.doi.org/10.2172/1328687.

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Williams, Dean. Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT). Office of Scientific and Technical Information (OSTI), 2011. http://dx.doi.org/10.2172/1022945.

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Williams, Dean. Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) Final Report. Office of Scientific and Technical Information (OSTI), 2014. http://dx.doi.org/10.2172/1136155.

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Chaudhary, Aashish. Ultra-Scale Visualization Climate Data Analysis Tools (UV-CDAT) Final Technical Report. Office of Scientific and Technical Information (OSTI), 2014. http://dx.doi.org/10.2172/1164136.

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Williams, D. Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT): Semi-Annual Progress Report. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1036837.

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Wheelock, Margaret. Expression of Inappropriate Cadherins in Human Breast Carcinomas-CDA. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada382945.

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