Academic literature on the topic 'CDK 5'

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Journal articles on the topic "CDK 5"

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Guidato, Sonia, Declan M. McLoughlin, Andrew J. Grierson, and Christopher C. J. Miller. "Cyclin D2 Interacts with cdk-5 and Modulates Cellular cdk-5/p35 Activity." Journal of Neurochemistry 70, no. 1 (2002): 335–40. http://dx.doi.org/10.1046/j.1471-4159.1998.70010335.x.

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Mostafa, Heba H., Jessica M. van Loben Sels, and David J. Davido. "Herpes Simplex Virus 1 Upregulates p35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons." Journal of Virology 89, no. 9 (2015): 5171–75. http://dx.doi.org/10.1128/jvi.00106-15.

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The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the cytoplasm, and enhances CDK-5 activity during lytic or acute infection. Infected neurons also stained positive for the DNA damage response (DDR) marker γH2AX. We propose that CDK-5 is activated by the DDR to protect infected neurons from apoptosis.
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Juo, Peter, Tom Harbaugh, Gian Garriga, and Joshua M. Kaplan. "CDK-5 Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Cord of Caenorhabditis elegans." Molecular Biology of the Cell 18, no. 10 (2007): 3883–93. http://dx.doi.org/10.1091/mbc.e06-09-0818.

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The proline-directed kinase Cdk5 plays a role in several aspects of neuronal development. Here, we show that CDK-5 activity regulates the abundance of the glutamate receptor GLR-1 in the ventral cord of Caenorhabditis elegans and that it produces corresponding changes in GLR-1–dependent behaviors. Loss of CDK-5 activity results in decreased abundance of GLR-1 in the ventral cord, accompanied by accumulation of GLR-1 in neuronal cell bodies. Genetic analysis of cdk-5 and the clathrin adaptin unc-11 AP180 suggests that CDK-5 functions prior to endocytosis at the synapse. The scaffolding protein
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Wu, F., S. Buckley, K. C. Bui, et al. "Cell cycle arrest in G0/G1 phase by contact inhibition and TGF-beta 1 in mink Mv1Lu lung epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 270, no. 5 (1996): L879—L888. http://dx.doi.org/10.1152/ajplung.1996.270.5.l879.

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We postulated that contact inhibition and transforming growth factor (TGF)-beta 1 may target the same molecules to negatively regulate the Mv1Lu cell cycle in G0/G1. Both contact inhibition and TGF-beta 1 suppressed the expression of a 45-kDa protein (p45); cyclins D2 and B1; cyclin-dependent protein kinase (Cdk)-4, Cdc-2, and Cdc-2-associated activity; and the phosphorylation of retinoblastoma tumor-suppressor protein (pRb) but did not affect the expression of cyclins D1, E, and A or the expression of Cdk-2 and Cdk-5. Expression of p45 reappeared 12 h after release from contact inhibition and
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Riess, Christin, Carl Friedrich Classen, and Claudia Maletzki. "HGG-07. CYCLIN-DEPENDENT KINASES AS TARGET STRUCTURES FOR CANCER THERAPY – A COMPARATIVE IN VITRO ANALYSIS ON PATIENT-DERIVED GLIOBLASTOMA CELL CULTURE MODELS." Neuro-Oncology 22, Supplement_3 (2020): iii345. http://dx.doi.org/10.1093/neuonc/noaa222.298.

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Abstract INTRODUCTION Current therapeutic approaches have limited clinical success for Glioblastoma patients, making novel strategies urgent. Cyclin-dependent kinases (CDK) are crucial in cell cycle, oncogenic transcription, DNA repair, and stem-cell renewal. Glioma cells frequently show genomic alterations in CDKs. Here, we evaluated the antitumoral activity of selective CDK inhibitors (CDKI) abemaciclib (CDK4/6), palbociclib (CDK4/6), and dinaciclib (CDK1/2/5/9) alone and in combination with chemo-/radiotherapy. MATERIALS/ METHODS Low passage glioblastoma cell lines (N=5) with different mole
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Nishizawa, Masafumi, Yuko Kanaya, and Akio Toh-e. "Mouse Cyclin-dependent Kinase (Cdk) 5 Is a Functional Homologue of a Yeast Cdk, Pho85 Kinase." Journal of Biological Chemistry 274, no. 48 (1999): 33859–62. http://dx.doi.org/10.1074/jbc.274.48.33859.

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Yigit, Gökhan, Karen E. Brown, Hülya Kayserili, et al. "Mutations in CDK 5 RAP 2 cause Seckel syndrome." Molecular Genetics & Genomic Medicine 3, no. 5 (2015): 467–80. http://dx.doi.org/10.1002/mgg3.158.

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Kong, Xiaotian, Huiyong Sun, Peichen Pan, et al. "Molecular principle of the cyclin-dependent kinase selectivity of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile derivatives revealed by molecular modeling studies." Physical Chemistry Chemical Physics 18, no. 3 (2016): 2034–46. http://dx.doi.org/10.1039/c5cp05622e.

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Turner, N. "Targeting the CDK 4-6 pathway." Breast 44 (March 2019): S7. http://dx.doi.org/10.1016/s0960-9776(19)30078-5.

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Silver, Debra L., and Denise J. Montell. "A New Trick for Cyclin-Cdk." Developmental Cell 4, no. 2 (2003): 148–49. http://dx.doi.org/10.1016/s1534-5807(03)00028-5.

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Dissertations / Theses on the topic "CDK 5"

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Even, Yasmine. "Caractéristiques et fonctions d'une Cdk-like, CDC2L5." Paris 6, 2005. http://www.theses.fr/2005PA066136.

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Weitensteiner, Sabine. "Cyclin-dependent kinase 5 in endothelial cell migration: Elucidating regulatory mechanisms upstream of Cdk5 and evaluating novel Cdk inhibitors as anti-angiogenic drugs." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-136480.

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Weitensteiner, Sabine [Verfasser], and Stefan [Akademischer Betreuer] Zahler. "Cyclin-dependent kinase 5 in endothelial cell migration : elucidating regulatory mechanisms upstream of Cdk5 and evaluating novel Cdk inhibitors as anti-angiogenic drugs / Sabine Weitensteiner. Betreuer: Stefan Zahler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1017233233/34.

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Böttler, Tobias Elmar. "Rolle von CD4 +CD2 5+ regulatorischen T-Zellen bei der chronischen HCV-Infektion." [S.l. : s.n.], 2005.

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Silva, Vivian Helena Iida Avelino da. "Avaliação da imunogenicidade e reatogenicidade da vacina contra febre amarela em pessoas que vivem com HIV." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-06012016-112024/.

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INTRODUÇÃO: A vacina contra febre amarela é a principal forma de prevenção da doença, e é raramente associada a eventos adversos graves, para os quais pessoas que vivem com o vírus da imunodeficiência humana (HIV) teoricamente possuem risco aumentado. Nessa população, estudos sugerem que a imunogenicidade da vacina é inferior, e fatores associados à resposta vacinal são pouco conhecidos. Neste estudo, avaliamos a imunogenicidade e reatogenicidade da vacina contra febre amarela em pessoas infectadas por HIV e controles, comparando os títulos de anticorpos neutralizantes, ocorrência de viremia p
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Lefèvre, Guillaume. "Caractérisation immunophénotypique, histopathologique et moléculaire des Syndromes HyperEosinophiliques lymphoïdes avec lymphocytes T CD3-CD4+ circulants." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S001/document.

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Le syndrome hyperéosinophilique dit "lymphoïde" avec cellules T circulantes CD3-CD4+ (SHE-L CD3-CD4+) se caractérise par une hyperéosinophilie secondaire à la présence d'un clone lymphocytaire T producteur de cytokines comme l'IL-5. Trente patients seulement ont été rapportés dans la littérature, neuf d'entre eux ont présenté un lymphome T périphérique au cours du suivi. Il n'existe aucune grande série de la littérature décrivant les données cliniques, les caractéristiques immunophénotypiques, histopathologiques et moléculaires de la maladie. Le travail de Thèse a permis de confirmer la prédom
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Bajaj, Narinder Singh. "Cyclin dependent kinase 5 (CDK5) and neurodegeneration." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312768.

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Giavina-Bianchi, Mara Huffenbaecher. "Análise da expressão da proteína NY-ESO-1 no melanoma cutâneo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-20062016-111434/.

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INTRODUÇÃO: o câncer é a doença que mais mata pessoas com idade abaixo de 85 anos e é um problema de saúde pública. Os tumores podem expressar em determinada fase de seu desenvolvimento proteínas anômalas que podem ser alvo de métodos diagnósticos e de intervenções terapêuticas. A expressão de NY-ESO-1 é detectada em 20 a 40% dos melanomas. Há evidências que esta expressão é mais freqüente em tumores de estágios mais avançados e está associada a um pior prognóstico. OBJETIVOS: determinar a frequência de expressão da proteína NY-ESO-1 no melanoma cutâneo e tentar correlacioná-la com o índice de
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Jämsä, Anne. "In vitro modelling of tau phosphorylating kinases: emphasis on Cdk5 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-400-6/.

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Guimarães, Tathiane Barbosa. "Perfil psicossocial de portadores de CDI: COMFORT-CDI." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-24102016-154635/.

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Introdução: Ansiedade, depressão, personalidade Tipo D e terapias de choque do cardioversor-desfibrilador implantável (CDI) são fatores de risco para pior ajuste psicossocial. Além da maior parte dos estudos serem realizados em países desenvolvidos, pouca atenção é dada a estes e outros fatores, assim como à influência na percepção de portadores de CDI quanto à sua cardiopatia de base. Estratégias de enfrentamento, diferença entre percepção do CDI e da doença, assim como percepção dos familiares também têm sido negligenciadas. Os objetivos deste estudo foram descrever o perfil psicossocial de
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Books on the topic "CDK 5"

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Ip, Nancy Y., and Li-Huei Tsai, eds. Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6.

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Grimm Brothers. Bruder Grimm. Die Marchen Box. 5 CDs. Argon Verlag, 2006.

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Schmid, Josef. Die CDU. VS Verlag für Sozialwissenschaften, 1990. http://dx.doi.org/10.1007/978-3-322-95555-5.

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PRESS, M/SMICROSOFT. Microsoft Word 5 for the Macintosh Courseware Developer's Kit(cdk). Microsoft Press,U.S., 1993.

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Puzo, Mario, and Charles Brauer. Omerta. 5 CDs. Ullstein Hörverlag, 2001.

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Nazer, Mende, and Damien Lewis. Sklavin. 5 CDs. Droemersche Verlagsanstalt Th. Knaur Nachf., GmbH & Co., 2002.

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Marklund, Liza. Paradies. 5 CDs. Hoffmann und Campe, 2002.

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Mues, Dietmar, and Friedrich Ani. Verzeihen. 5 CDs. Droemer Knaur, 2002.

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Opferzahl (5 CDs). 2011.

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Pilcher, Rosamunde. Wintersonne. 5 CDs. Ullstein Hörverlag, 2001.

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Book chapters on the topic "CDK 5"

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Wei, Fan-Yan, and Kazuhito Tomizawa. "Cdk5 in Presynapses." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_3.

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Ohshima, Toshio. "Cdk5/p35 Regulates Neuronal Migration." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_1.

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Wen, Yi, Haung Yu, and Karen Duff. "Cdk5 and Neuregulin-1 Signaling." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_10.

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Musacchio, Andrea. "The Structural Bases of CDK5 Activity." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_14.

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Meuer, Katrin, Mathias Bähr, and Jochen H. Weishaupt. "CDK5 and Mitochondrial Cell Death Pathways." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_7.

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Freidinger, R. M., W. L. Whitter, R. S. L. Chang, V. J. Lotti, and D. F. Veber. "CYCLIC HEXAPEPTIDE CCK ANTAGONISTS." In Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986, edited by Dimitrios Theodoropoulos. De Gruyter, 1987. http://dx.doi.org/10.1515/9783110864243-105.

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Dubbs, John D., and Ken Kreinbrink. "Construction, Commissioning and Initial Operation of 2400W Refrigerator and Cold Test Stand for CDM Testing." In Supercollider 5. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2439-7_20.

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Bark, Christina, Marjan Rupnik, Marko Jevsek, Slavena A. Mandic, and Per-Olof Berggren. "Cyclin-Dependent Kinase 5 and Insulin Secretion." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_11.

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Ng, Gary Kar Ho, Lisheng He, and Robert Z. Qi. "Protein–Protein Interactions Involving the N-Terminus of p35." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_12.

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Hisanaga, Shin-ichi, and Koichi Ishiguro. "The Kinase Activity of Cdk5 and Its Regulation." In Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78887-6_13.

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Conference papers on the topic "CDK 5"

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Nguyen, Tri K., and Steven Grant. "Abstract 2686: The CDK inhibitor dinaciclib (SCH727965) inhibits the unfolded protein response (UPR) through a CDK1- and CDK5-dependent mechanism." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2686.

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Shapiro, Geoffrey, Magnus Neumuller, Sara Lööf, et al. "Abstract 2340: Thymidine kinase activity as a response marker for CDK 4/6 inhibition." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2340.

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Simons, Brian W., Maria Ybanez, Emmanuel S. Antonarakis, Jun Luo, and Barry D. Nelkin. "Abstract 2171: Multi-CDK inhibition efficiently suppresses AR function and cell growth in prostate cancer." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2171.

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Yin, Hong. "Abstract 1326: Regulation of AKT phosphorylation by a CDK inhibitor purvalanol A in breast cancer cells." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1326.

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Mazumdar, Abhijit, Jamal Hill, Yun Zhang, et al. "Abstract 5525: Induced expression of PPM1A in ER-negative breast cancer cells inhibits growth by suppressing CDK phosphorylation." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5525.

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Mayer, EL, SA Wander, MM Regan, et al. "Abstract OT3-05-11: Palbociclib after CDK inhibitor and endocrine therapy (PACE): A randomized phase II study of fulvestrant versus palbociclib plus fulvestrant, with and without avelumab, for CDK inhibitor pre-treated HR+/HER2- metastatic breast cancer." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-ot3-05-11.

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Chaturvedi, Nagendra K., Nathan D. Hatch, Garrett L. Sutton, Matthew J. Kling, Julie M. Vose, and Shantaram S. Joshi. "Abstract 4051: Combination efficacy of HDAC inhibitor vorinostat and CDK-4/6 dual inhibitor palbociclib against therapy-resistant mantle cell lymphoma." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4051.

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Finn, RS, Y. Liu, M. Martin, et al. "Abstract P2-09-10: Comprehensive gene expression biomarker analysis of CDK 4/6 and endocrine pathways from the PALOMA-2 study." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p2-09-10.

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Shapiro, Geoffrey I., Khanh T. Do, Sara M. Tolaney, et al. "Abstract CT047: Phase 1 dose-escalation study of the CDK inhibitor dinaciclib in combination with the PARP inhibitor veliparib in patients with advanced solid tumors." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-ct047.

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Hollebecque, Antoine, Charles Ferte, Gerard Nitenberg, et al. "Abstract 900: Computing tumor growth rate across pre- and post-treatment periods uncovers anti-tumor activity in patients treated by a pan-CDK inhibitor (BAY1000394)." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-900.

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Reports on the topic "CDK 5"

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Merk, Christine. Summary report on Workshop 1 laypersons’ perceptions of marine CDR, Deliverable 3.1. OceanNETs, 2021. http://dx.doi.org/10.3289/oceannets_d3.1.

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This deliverable reports about the successful completion of three group discussions on marine carbon dioxide removal (CDR) with laypersons in Germany. The 2-hour group discussions were held online. 5 participants discussed these three topics: (1) the environmental state of the oceans, (2) four selected marine CDR approaches, and (3) responsible research and innovation. The four approaches were ocean fertilization, ocean alkalinization via ocean liming and electrochemical weathering in desalination plants, artificial upwelling, and blue carbon management via kelp forests, mangroves and seagrass
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Althoff, J. L., M. L. Apicella, and S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 3. CDM1: IDEF1 Model of the CDM -- CDM Development Specification. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada252448.

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Apicella, M. L., R. Palumbo, and S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 1. CDM Administrator's Manual. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada250448.

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Rollins, D., M. Loomis, J. Hogan, and B. Leifeste. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 1. CDM Administrator's Manual. Defense Technical Information Center, 1985. http://dx.doi.org/10.21236/ada181577.

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Bridges, Kate. 2018 Mid-Term Elections: Insights from New Jersey CD-5 Voters Age 50+. AARP Research, 2018. http://dx.doi.org/10.26419/res.00245.032.

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Apicella, M. L., and S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 39. CDM Impact Analysis Development Specification. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada250472.

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Apicella, M. L., and S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 41. CDM Impact Analysis User's Manual. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada250473.

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Apicella, M. L., and S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 43. CDM Compare Utility Development Specification. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada250475.

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Apicella, M. L., and S. Singh. Integrated Information Support System (IISS). Volume 5 - Common Data Model Subsystem. Part 45 - CDM Compare Utility User's Manual. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada250628.

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Mann, D., and D. Thompson. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 49. CDM IRDS Feature Evaluation Report. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada250480.

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