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Dissertations / Theses on the topic 'CDNA microarray'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Fraser, Karl. "cDNA microarray image analysis : a fully automated framework." Thesis, Brunel University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429240.

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2

Stanzel, Sven. "Optimale statistische Versuchsplanung dreifaktorieller Zwei-Farben-cDNA-Microarray-Experimente /." Dortmund, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254108.

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3

Soneji, Sharnit. "Statistical Analysis of cDNA Microarray Directed by Gene Function." Thesis, Birkbeck (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487759.

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Microarrays allow the expression level of thousands of genes to be measured simultaneously. This study will address analytical issues predominantly concerned with eDNA arrays. These include normalisation and data preprocessing, leading to an assessment of cluster analysis and the integration of database information to elucidate functional classes of biological relevance. This is then extended further to classify genes of unknown function using Markov Random Fields. I Modelling of uneven surface trends were considered in a new 2D-normalisation method which outperformed the popular loess method

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Jouenne, Vincent Y. "Critical Issues in the Processing of cDNA Microarray Images." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/33960.

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Microarray technology enables simultaneous gene expression level monitoring for thousands of genes. While this technology has now been recognized as a powerful and cost-effective tool for large-scale analysis, the many systematic sources of experimental variations introduce inherent errors in the extracted data. Data is gathered by processing scanned images of microarray slides. Therefore robust image processing is particularly important and has a large impact on downstream analysis. The processing of the scanned images can be subdivided in three phases: gridding, segmentation and data extract

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5

Wu, Meng. "Data mining cDNA microarray experiment with a GEE approach /." Electronic version (PDF), 2004. http://dl.uncw.edu/etd/2004/wum/mengwu.pdf.

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6

Hintze, Eric Poole. "Small sample multiple testing with application to cDNA microarray data." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4319.

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Many tests have been developed for comparing means in a two-sample scenario. Microarray experiments lead to thousands of such comparisons in a single study. Several multiple testing procedures are available to control experiment-wise error or the false discovery rate. In this dissertation, individual two-sample tests are compared based on accuracy, correctness, and power. Four multiple testing procedures are compared via simulation, based on data from the lab of Dr. Rajesh Miranda. The effect of sample size on power is also carefully examined. The two sample t-test followed by the Benjamini an

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7

Vesterlund, Jacob. "Feature Selection and Classification of cDNA Microarray Samples in ROSETTA." Thesis, Uppsala University, Department of Information Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-88731.

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<p>The advent of cDNA microarray technology makes it possible to measure theexpression level of thousands of genes simultaneously. This creates large volumes of data that require computational analysis.</p><p>One application of microarray technology is cancer studies, where supervised learning may be used on microarray data to predicting tumour subtypes and other clinical parameters. The number of available objects (microarrays) is much smaller than the number of attributes (genes). Hence it is necessary to determine which attributes are important for predicting a parameter. Feature selection

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8

Zhu, Ximin. "Topics on statistical design and analysis of cDNA microarray experiment." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1206/.

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A microarray is a powerful tool for surveying the expression levels of many thousands of genes simultaneously. It belongs to the new genomics technologies which have important applications in the biological, agricultural and pharmaceutical sciences. In this thesis, we focus on the dual channel cDNA microarray which is one of the most popular microarray technologies and discuss three different topics: optimal experimental design; estimating the true proportion of true nulls, local false discovery rate (lFDR) and positive false discovery rate (pFDR) and dye effect normalization. The first topic

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9

Zhao, Hongya. "Statistical analysis of gene expression data in cDNA microarray experiments." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/657.

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10

Kan, Takatsugu. "Gene expression profiling in human esophageal cancers using cDNA microarray." Kyoto University, 2003. http://hdl.handle.net/2433/148738.

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11

Huang, Liping. "STATISTICAL METHODS IN MICROARRAY DATA ANALYSIS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/795.

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This dissertation includes three topics. First topic: Regularized estimation in the AFT model with high dimensional covariates. Second topic: A novel application of quantile regression for identification of biomarkers exemplified by equine cartilage microarray data. Third topic: Normalization and analysis of cDNA microarray using linear contrasts.

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12

Maughan, Michele Nancy. "Molecular detection and identification of avian influenza viruses by cDNA microarray." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 141 p, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1440635.

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13

Moore, Heather Corrina. "Genetic Profiling of the Bovine Pituitary Gland Using cDNA Microarray Technology." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194108.

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Goals of this dissertation were to 1) use custom-made cDNA microarrays to identify genes in the bovine pituitary gland that are differentially expressed during the estrous cycle and 2) characterize their patterns of gene expression. The estrous cycle is a dynamic process that requires coordination between the hypothalamus, pituitary gland, and ovaries. The anterior pituitary gland synthesizes and secretes the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulate steroidogenesis and follicular development. Currently, intrapituitary factors that modulate

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14

Dantas, Daniel Oliveira. "Uma técnica automática baseada em morfologia matemática para a medida de sinal de imagens de cDNA." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/45/45134/tde-20062016-125151/.

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O objetivo deste trabalho é apresentar uma técnica automática baseada em morfologia matemática para medida de sinal em imagens de cDNA desenvolvida no BIOINFO,em parceria com o Instituto Ludwig de Pesquisa contra o Câncer. A tecnologia de lâminas de cDNA é um processo baseado em hibridização que possibilita observar a concentração relativa de mRNA de amostras de tecidos analisando a luminosidade de sinais fluorescentes ou radioativos. Hibridização é o processo bioquímico onde duas fitas de ácido nucleico com seqüências complementares se combinam. A técnica apresentada permite o cálculo da ex

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Howell, Brandon George. "Gene expression profiling of UV-induced skin cancer using cDNA microarray technology." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63108.pdf.

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16

Van, Laar Ryan. "Optimisation of cDNA microarray tumour profiling and molecular analysis of epithelial ovarian cancer /." Connect to thesis, 2005. http://eprints.unimelb.edu.au/archive/00002764.

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17

Erxleben, Franziska [Verfasser], and Tanja [Akademischer Betreuer] Schirmeister. "cDNA-Microarray-Analyse von ZNS-Kaliumkanal defizienten Mäusen / Franziska Erxleben. Betreuer: Tanja Schirmeister." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1016615108/34.

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18

Varotto, Laura. "Sviluppo e validazione di un cDNA microarray a scala genomica in Mytilus galloprovincialis." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3426736.

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Marine bivalves of the genus Mytilus are intertidal filter-feeders commonly used as biosensors of coastal pollution. Indeed, mussels readily bioaccumulate both organic and metal pollutants, and react to changes with physiological and genetic mechanisms. However, one main problem in using mussels as bio-sensors is the poor characterization of their functional and defence reactions. The currently used biomarkers provide insufficient understanding of mussel physiology status or stressor-induced effects, and knowledge of mussel genome structure, function and evolution are still lacking. Therefore,

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Mantri, Nitin Laxminarayan, and nitin_mantri@rediffmail com. "Gene expression profiling of chickpea responses to drought, cold and high-salinity using cDNA microarray." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080509.160714.

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Cultivated chickpea (Cicer arietinum) has a narrow genetic base making it difficult for breeders to produce new elite cultivars with durable resistance to major biotic and abiotic stresses. As an alternative to genome mapping, microarrays have recently been applied in crop species to identify and assess the function of putative genes thought to be involved in plant abiotic stress and defence responses. In the present study, a cDNA microarray approach was taken in order to determine if the transcription of genes, from a set of previously identified putative stress-responsive genes from chickpea

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20

McDowell, Susan Ann. "MEDIATION OF NICKEL-INDUCED ACUTE LUNG INJURY BY NITRIC OXIDE." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin999025181.

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21

Stolf, Beatriz Simonsen. "Identificação de marcadores moleculares para o câncer de tireóide por cDNA microarrays." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-21072008-101124/.

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Doenças tireoideanas são bastante comuns, sendo sua maioria benigna. A relação entre os diversos tipos de doenças tireoideanas, bem como seus aspectos moleculares, são pouco conhecidos. O bócio (hiperplasia), por exemplo, é descrito por alguns como relacionado com carcinoma (tumor maligno) papilífero, enquanto que outros afirmam não haver relação causal entre as duas doenças. A questão mais desafiante, porém, refere-se à distinção entre adenoma (tumor benigno) e carcinoma folicular, que atualmente é feita apenas após à cirurgia, não permitindo tratamento diferenciado para os dois tipos de tumo

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22

Ferreira, Maidy Rehder Wimmers. "Avaliação do perfil de expressão gênica em grande escala de células indiferenciadas da polpa e de células odontoblásticas utilizando cDNA microarray." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-09062011-094759/.

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O extraordinário potencial regenerativo do complexo dentino-pulpar enfatiza a importância da caracterização dos processos celulares e moleculares envolvidos na regeneração dentinária. O avanço da pesquisa com células-tronco desencadeou um grande interesse de cultivá-las na presença de sinais de indução odontogênica. O objetivo do presente trabalho foi avaliar comparativamente células indiferenciadas da polpa (OD-21) e odontoblásticas (MDPC-23) através da avaliação do estímulo celular e do perfil de expressão gênica. As células OD-21 e MDPC-23 foram cultivadas em garrafas de cultura até a subco

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23

Yang, Xiao. "Optimal Design of Single Factor cDNA Microarray experiments and Mixed Models for Gene Expression Data." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/26379.

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Microarray experiments are used to perform gene expression profiling on a large scale. E- and A-optimality of mixed designs was established for experiments with up to 26 different varieties and with the restriction that the number of arrays available is equal to the number of varieties. Because the IBD setting only allows for a single blocking factor (arrays), the search for optimal designs was extended to the Row-Column Design (RCD) setting with blocking factors dye (row) and array (column). Relative efficiencies of these designs were further compared under analysis of variance (ANOVA) models

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24

Brendel, Michael. "Etablierung einer cDNA-Microarray-Technologie zur Genexpressionsanalyse bei akuter und chronischer allogener Lungenschädigung nach Lungentransplantation." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-104358.

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25

Esteves, Gustavo Henrique. "Métodos estatísticos para a análise de dados de cDNA microarray em um ambiente computacional integrado." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-03062007-210232/.

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Análise de expressão gênica em larga escala é de fundamental importância para a biologia molecular atual pois possibilita a medida dos níveis de expressão de milhares de genes simultaneamente, o que torna viável a realização de trabalhos voltados para biologia de sistemas (systems biology). Dentre as principais técnicas experimentais disponíveis para esta finalidade, a tecnologia de microarray tem sido amplamente utilizada. Este procedimento para medida de expressão gênica é bastante complexo e os dados obtidos são freqüentemente observacionais, o que dificulta a modelagem estatística. Não exi

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26

Filippi, Renée Zon. "Estudo da expressão das proteínas TFE3 e receptor de insulina nos hepatoblastomas a partir dos achados de expressão gênica." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-26012012-100515/.

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O hepatoblastoma é uma neoplasia embrionária hepática que ocorre na faixa pediátrica, rara, sendo bastante heterogênea devido aos seus diferentes componentes epiteliais e mesenquimais. Pouco ainda se sabe a respeito de sua patogênese. Utilizando um microscópio de captura a laser foram dissecadas áreas de componente epitelial do hepatoblastoma e áreas de tecido hepático adjacente não acometido. Destas amostras obtidas de pacientes não submetidos ao tratamento prévio, foram extraídos RNA e confeccionados cDNA microarrays, para análise comparativa da expressão gênica, seguida de validação por mét

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27

Gameeldien, Hajirah. "The identification of candidate genes using cDNA microarray and the analysis of two SNPs of the reelin gene in a South African austistic population." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3430_1297755889.

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<p>Autism is a pervasive developmental disorder (PDD) that&rsquo<br>s incidence is approximately 1 in 158. It is four times more prevalent in males than females and is believed to be caused by both genetic and environmental factors. Research indicates that several genes are involved in autism and it is believed that these genes act together to produce autism. Many genes implicated in this disorder are involved with brain structure formation and brain functioning. Studies have identified the reelin (RELN) gene as necessary for proper formation of brain, which indicates that RELN abnormalities c

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28

Brambrink, Tobias. "Entwicklung und Evaluierung eines Verfahrens zur Genexpressionsanalyse bei individuellen präimplantatorischen Säugerembryonen über die cDNA-Array-Technologie." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=968367275.

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Camilo, Cesar Moisés. "Regulação da expressão gênica por oxigênio no fungo aquático Blastocladiella emersonii." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-28042010-082547/.

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Neste trabalho realizamos a análise das variações na expressão gênica global do fungo aquático Blastocladiella emersonii submetido ao estresse de carência de oxigênio (hipóxia), utilizando a técnica de microarranjos de cDNA em lâminas contendo 3773 genes distintos. Nos experimentos de hipóxia gradual (diminuição gradual da concentração de oxigênio dissolvido, seguido de reoxigenação) e hipóxia direta (diminuição direta da concentração de oxigênio dissolvido, seguido de reoxigenação) observamos que 650 genes foram diferencialmente expressos em pelo menos uma das condições de estresse e que 534

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Barnhart, Kirstin Faye. "In vitro and in vivo analysis of differential gene expression between normal norfolk terrier dogs and those with an autosomal recessive mutation in KRT10." Texas A&M University, 2004. http://hdl.handle.net/1969.1/2671.

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Natural diseases caused by keratin mutations are rare and have only been reported in humans. We have recently identified a heritable skin disorder in Norfolk terriers caused by a mutation in KRT10. Affected dogs have a tendency to form shallow erosions or blisters following mild trauma, which is first noted after the birthing process. As the dogs age, they display generalized hyperpigmentation and scaling that is most severe in the axillary and inguinal regions. The main histologic and ultrastructural features include: marked hyperkeratosis, epidermal hyperplasia, prominent vacuolation of the

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31

Yeoh, Sue-Ching. "Gene Expression Profiling Of Two Oral Squamous Cell Carcinoma Cell Lines Compared With Normal Oral Epithelium, Using Cdna Microarray." Thesis, Faculty of Dentistry, 2006. http://hdl.handle.net/2123/5040.

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32

Huang, Shih-Po, and 黃仕柏. "Fluorescence Scanner System of cDNA Microarray." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/89658607932288024193.

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33

"cDNA microarray analysis of digit regeneration." Tulane University, 2003.

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To establish a better understanding of the neonatal mammalian digit tip regeneration response, a custom cDNA microarray consisting of regeneration specific genes was created. Combinations of several normalizations were used to account for biases inherent in the array. From this subset of clones, one gene found to be differentially expressed in non-regenerating digits was Keratin 6b. Keratin 6b mRNA was seen in the entire wound edge of non-regenerating digits but only on the ventral side of the regenerating digit. Further analysis found that Keratin 6b is expressed in a symmetrical pattern in e

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34

Chen, Chin-Hau, and 陳智豪. "Data Analysis for cDNA Microarray Experiments." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/67426590520563383236.

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碩士<br>國立臺灣大學<br>農藝學研究所<br>90<br>In general,the experiment data collected from the two-dye cDNA microarrays can be classified into the single-array data and the replicated-array data.And the statistical approach to analyzing microarray data is not the same for these two types of data.Regardless of single or replicated microarray experiments,there are many sources of systematic variation which may affect the really expression values of cDNA.Normalization is the term used to describe the process of removing such systematic variation.Our research is based on a publicly available cDNA microarray da

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Dao-Peng, Chen, and 陳道鵬. "2k factorial design for cDNA microarray experiment." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/00846700121790609598.

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Δασκαλάκης, Αντώνιος. "Optimization of cDNA microarray image analysis methods." Thesis, 2009. http://nemertes.lis.upatras.gr/jspui/handle/10889/2957.

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The expression of genetic information, in all organisms, might be characterized as in a constant state of flux with only a fraction of the gene within a genome being expressed at any given time. The genes’ expression pattern reflects the response of cells to stimuli that control growth, development and signal environmental changes. Understanding genes’ expression at the level of transcription and/or other stages of gene regulation at the mRNA level (half life of mRNA, RNA production from primary transcript) might reveal insights into the genes expression mechanisms that control these changes.

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Chou, Ting-Yu, and 周庭毓. "A Quality Measure for cDNA Microarray Data." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/30720559710038418212.

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碩士<br>國立成功大學<br>統計學系碩博士班<br>94<br>Microarray experiment is a useful way to observe the display for thousands of genes simultaneously. To improve the reliability of dowe-stream data analysis, a quantity to evaluate the quality of microarray chip is established. Motivated by the MA-plot of Dudoit et al. (2002), we develop a statistic E(|I|) to measure the quality of one microarray chip. Simulation study shows that E(|I|) is able to distinguish the chip quality effectively. Furthermore, we suggest one threshold value |I|* for purpose of diagnosis. The quality of one chip is acceptable if the E(|I

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Howlader, Tamanna. "Wavelet-based noise reduction of cDNA microarray images." Thesis, 2009. http://spectrum.library.concordia.ca/976541/1/NR63377.pdf.

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The advent of microarray imaging technology has lead to enormous progress in the life sciences by allowing scientists to analyze the expression of thousands of genes at a time. For complementary DNA (cDNA) microarray experiments, the raw data are a pair of red and green channel images corresponding to the treatment and control samples. These images are contaminated by a high level of noise due to the numerous noise sources affecting the image formation. A major challenge of microarray image analysis is the extraction of accurate gene expression measurements from the noisy microarray images. A

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Lee, Han-Ni, and 李涵妮. "The Applications of cDNA Microarray in Reproductive Medicine:." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/08032208066072415445.

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碩士<br>臺北醫學大學<br>醫學研究所<br>91<br>Part I: To Study the Pathological Mechanisms and Markers for Endometriosis Endometriosis is one of the most common gynecological diseases and about 40 % of infertile women have endometriosis. The gonadotropin releasing hormone analog (GnRHa) has been widely used in the treatment of endometriosis for many years. However, the genetic mechanisms and diagnostic marker of endometriosis are still unclear. In this study, the global gene expression profiles in endometric tissues (chocolate cysts) which have been treated with or without GnRHa were analyzed by u

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Shih, Chiao-Ling, and 史巧菱. "cDNA Microarray Images Processing Using Mathematical Morphology Mehtods." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/17132502324827082630.

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碩士<br>臺北醫學大學<br>醫學資訊研究所<br>92<br>cDNA microarray is widely used to identify and quantify different gene-expression for large-scale analysis. In order to extract microarray data precisely from microarray images, robust image processing is indispensable. Most microarray image processing methods are still semi-automatic because of the variations between different arrayers and spots properties. Besides, in a research always use many cDNA microarrays, and a cDNA microarray allow the monitoring of expressions for tens of thousands of genes simultaneously.An automatic method to resolve these cDNA mic

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Chen, Li-Ju, and 陳麗如. "A New Normalization method for cDNA Microarray data." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/52459201763305882760.

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碩士<br>國立成功大學<br>統計學系碩博士班<br>91<br>Microarray experiment involves many steps, and for each step there may exist systematic variation. In order to making correct decision, this systematic bias has to be identified and be removed before analyzing data. Based on the concept of lowess normalization process suggested by Dudoit et al. (2001), a more appropriate normalization method would be presented in this thesis to deal with genes with replicate expressions. Simulation study shows that the performance of the suggested normalization method is superior to the available approaches. We use a microarra

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王陽照. "Design and Data Analysis for cDNA Microarray Experiments." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/69683231926379526762.

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Chien, Liang-Hui, and 錢良蕙. "Identification of HBx responsive genes using cDNA microarray." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/82526938198842066438.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>90<br>The hepatitis B virus X protein (HBx) is thought to be involved in the development of hepatocellular carcinoma (HCC) , but its exact role in HCC remains unclear. HBx mainly acts as a transcriptional transactivator involving in multiple gene deregulations. To identify additional genes that may be affected by the HBx expression, we used an established inducible system HepG2-3x in which the expression of HBx in HepG2 cell line is inducible by the removal of doxycycline. We then performed a cDNA microarray analysis on an array (As-chip-TCL-03-Vo) contains 759 ge

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Erxleben, Franziska. "cDNA-Microarray-Analyse von ZNS-Kaliumkanal defizienten Mäusen." Doctoral thesis, 2011. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-65640.

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Ziel der Arbeit war die Erstellung eines „Kaliumkanal-Chips“, die Entwicklung einer geeigneten Messmethode und Auswertungsstrategie, die Durchführung von Testmessungen und die Untersuchung eines Knockout-Mausstammes auf den Genexpressionsstatus und die auftretenden Kompensationsmechanismen. Am Beginn der Arbeit stand vor allem die Auswahl der zu untersuchenden Kaliumkanal-Gene und die Sammlung von Sequenz-Informationen. Ausgehend davon konnte die cDNAMicroarray-Technologie als Methode der Wahl bestimmt werden und die entsprechenden Vorbereitungen für die Umsetzung getroffen werden. Die ersten

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Liao, Tzu-chi, and 廖姿淇. "Post-chip quality assessment for cDNA microarray data." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/88644011374315641059.

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碩士<br>國立成功大學<br>統計學系碩博士班<br>95<br>With the prominent advance of microarray technology, people can observe thousands of gene expressed values simultaneously. To have valid results, quality control on array data becomes a necessary and important step before analysis is performed. In this thesis, motivated by the M-A plot of Dudoit et al. (2002), quality indexes, β1、σR'/σG'and ρR'G'are proposed to assess the array quality. Simulation study shows that σR'/σG'and ρR'G'both have large influence on array quality. In practice, theses arrays with high σR'/σG'and low ρR'G'could be considered as outliers

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Cheng, Kuang-Hong, and 鄭光泓. "Surface Morphology Study of cDNA Microarray Probe Spots." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/62397073134800143095.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>96<br>AbstractcDNA microarray contains densely packed spots with known DNA sequences. The deposited DNA sample is referred to as the probe. After the fluorescently-labeled target DNA is hybridized to its complementary probe strand, the microarray was scanned to measure the intensity of the fluorescent signals on each spot. The intensity of each spot represents the expression level of a specific gene. However, the DNA distribution within each spot will influence the analysis of the fluorescent signals. This research aims at applying the spectral images technology a

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Chang, Huang Kuo, and 黃國彰. "Data analysis for the influence of cDNA microarray normalization." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/86562168067076385446.

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米忻超. "The Analysis of Dye Effect for cDNA Microarray Experiment." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/43404841615118055761.

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Chen, Shih-Fang, and 陳世芳. "Application of Circular Hough Transform on cDNA Microarray Analysis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51224823733496823834.

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碩士<br>國立臺灣大學<br>生物產業機電工程學研究所<br>94<br>In this research, we used circular Hough transform to be the core method to search circular spots in microarray images. Due to high sensitivity of circular Hough transform to noises in an image, noise removal plays a very important role in image pre-processing. At first, we used histogram equalization to enhance the contrast of images before image thresholding. As a result, it is easier to separate foreground pixels from the background using the Otsu’s method to find the best threshold value. Following image binarization, we used blob algorithm to filter n

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Wu, Wei Cheng, and 吳偉誠. "cDNA Microarray Analysis of Human Keratinocytes Irradiated by Microwave." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/08614721659120620732.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>94<br>ABSTRACT The biological effects of microwave(300MHz~300GHz) have remained contentious. This study considers the subject from the following two aspects: (1) the non-thermal effects of microwave, (2) the interference of non-thermal effects from microwave on cell repair process. We used two biological experiments colony assay and cDNA microarray to explain cell proliferation and gene expression after 2.45GHz, 4mW/cm2 microwave exposure at 37°C. Firstly, the colony assay experiment showed that cell proliferation decreased significantly after cell was exposed

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