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Wye, Lesley. "Mainstreaming complementary therapies into primary care : the role of evidence, 'ideal' service design and delivery and alterations in clinical practice." Thesis, University of Bristol, 2007. http://hdl.handle.net/1983/1b79be36-ce50-46ce-ab4d-a5dbdd80bbf1.
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Ponce, Rodríguez Wilmer. "Estadística para Ingeniería I (CE54 / CE56), año 2013." Universidad Peruana de Ciencias Aplicadas - UPC, 2013. http://hdl.handle.net/10757/294499.
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Hidalgo, Nicho Eduardo Alejandro. "Toxicidad de la mezcla binaria de los plaguicidas metomilo y rotenona en la “lenteja de agua” Lemna minor (Linnaeus, 1758)." Bachelor's thesis, Universidad Ricardo Palma, 2015. http://cybertesis.urp.edu.pe/handle/urp/698.
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Se evaluó la toxicidad individual y binaria de los plaguicidas metomilo y rotenona en la macrofita Lemna minor (Linnaeus, 1753) para determinar la acción sinérgica o antagónica de una mezcla equitóxica. Los ensayos se realizaron bajo condiciones de laboratorio (T 29 ± 2°C; H 48,6 ± 9,4 %) y los resultados fueron analizados con los programas estadísticos BMDS® y Probit para calcular la concentración efectiva media (CE50) a través de los parámetros Área de la Fronda (AF) y Nuevas Frondas (NF). Los resultados sugieren una mayor precisión al utilizar el Método del Punto de Referencia del programa BMDS® para el cálculo de la concentración efectiva. Adicionalmente, se calculó la concentración total de clorofila (CTC) y peso húmedo (PH) para determinar la inhibición del crecimiento (Ir). Del mismo modo, se realizó una comparación entre los valores NOAEL (nivel de efecto no observado) y LOAEL (nivel bajo de efecto observado) versus los valores de BMDL (límite inferior del punto de referencia) y BMD (nivel de variación en el punto de referencia), respectivamente. El análisis muestra que existe una mayor precisión al emplear los valores BMD y BMDL. La acción fitotóxica varió según el parámetro analizado. La CE50 mostró mayores valores en el parámetro NF (1079,22 mg·L-1 para rotenona; 7147,42 mg·L-1 para metomilo; 597,904 mg·L-1 mezcla binaria: metomilo y 298,93 mg·L-1 mezcla binaria: rotenona) que en el parámetro AF (782,173 mg·L-1 para rotenona; 6919,79 mg·L-1 para metomilo; 629,513 mg·L-1 mezcla binaria: metomilo y 314,754 mg·L-1 mezcla binaria: rotenona). Finalmente, el modelo de concentración-adición mostró que la acción fitotóxica de la mezcla de ambos plaguicidas en Lemna minor tiene un efecto sinérgico.
Macrophyte Lemna minor (Linnaeus, 1753) was used to evaluate the phytotoxicity of the individual and mix action of methomyl and rotenone pesticides under laboratory conditions (Temperature 29 ± 2°C; Humidity 48,6 9,4 %). The taken measures to establish half effective concentration (EC50) were the frond area (AF) and production of new fronds (NF). In this study, BMDS® and Probit stadistical data analyses were used to compare the results about effective concentration. Results suggest Benchmark dose method of BMDS® program was more effective than Probit program when EC50 were determined. Additionally, total chlorophyll concentration (CTC) and humidity weight (PH) parameters were calculated to determinate the growth inhibition (Ir). Likewise, NOAEL (no observed adverse effect level) and LOAEL (low observer adverse effect level) were compared with BMDL (lower bench mark dose) and BMD (Bench mark dose), respectively. BMD and BMDL values were more accurate than NOAEL and LOAEL values. Phytotoxic action varied according the parameter. EC50 values of Lemna minor showed poor sensibility to methomyl pesticide with an elevated concentration in both parameters (6919,79 mg•L-1 and 7147,42 mg•L-1 for AF and NF, respectively). Results of rotenone pesticide were lower than methomyl, with 1079,22 mg•L-1 (NF) and 782,173 mg•L-1 (AF). Finally, the mix toxicity was 597,904 mg•L-1 (methomyl: NF), 298,93 mg•L-1 (rotenone: NF), 629,513 mg•L-1 (methomyl: AF) and 314,754 mg•L-1 (rotenone: AF). For synergy calculation, Concentration-Adition value was used, concluding a higher synergism.
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Angelica, Cortez Centeno Rosario, Gonzales Hernandez Cintya Sherley, and Saravia Yataco Nilton Cesar. "Matemática Básica (Fds)-CE80-201401." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/637105.
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El curso tiene como finalidad consolidar en el alumno su formación en los conocimientos y principios básicos de la matemática en la educación superior dentro del marco de los valores principios y modelo educativo por competencias que rigen en la UPC para ello brinda al alumno el uso de sólidos conocimientos de lógica inferencial álgebra elemental y de funciones aritmética básica proporcionalidad porcentajes interés simple y compuesto ecuaciones lectura de gráficos y funciones que le permiten modelar plantear y resolver situaciones y/o problemas numéricos en contextos reales de su quehacer laboral. El curso se desarrollará a través de clases presenciales y virtuales donde se presentaran actividades controles material autónomo de trabajo casos prácticos videos y ejercicios aplicados a su realidad.
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Angelica, Cortez Centeno Rosario. "Matemática Básica (Fds)-CE80-201400." Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/637104.
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El curso brinda al alumno el uso de nociones básicas de proporcionalidad porcentajes ecuaciones de primer grado lectura de gráficos y funciones que le permiten resolver situaciones y problemas numéricos reales en su día a día. El curso de desarrollará a través de problemas y ejercicios aplicados
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Angelica, Cortez Centeno Rosario. "Matemática Básica (Fds)-CE80-201402." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/637106.
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El curso tiene como finalidad consolidar en el alumno su formación en los conocimientos y principios básicos de la matemática en la educación superior dentro del marco de los valores principios y modelo educativo por competencias que rigen en la UPC para ello brinda al alumno el uso de sólidos conocimientos de lógica inferencial álgebra elemental y de funciones aritmética básica proporcionalidad porcentajes interés simple y compuesto ecuaciones lectura de gráficos y funciones que le permiten modelar plantear y resolver situaciones y/o problemas numéricos en contextos reales de su quehacer laboral. El curso se desarrollará a través de clases presenciales y virtuales donde se presentaran actividades controles material autónomo de trabajo casos prácticos videos y ejercicios aplicados a su realidad.
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Angelica, Cortez Centeno Rosario. "Matemática Básica (Fds)-CE80-201500." Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/637107.
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El curso tiene como finalidad consolidar en el alumno su formación en los conocimientos y principios básicos de la matemática en la educación superior dentro del marco de los valores principios y modelo educativo por competencias que rigen en la UPC para ello brinda al alumno el uso de sólidos conocimientos de lógica inferencial álgebra elemental y de funciones aritmética básica proporcionalidad porcentajes interés simple y compuesto ecuaciones lectura de gráficos y funciones que le permiten modelar plantear y resolver situaciones y/o problemas numéricos en contextos reales de su quehacer laboral. El curso se desarrollará a través de clases presenciales y virtuales donde se presentaran actividades controles material autónomo de trabajo casos prácticos videos y ejercicios aplicados a su realidad.
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Miguel, Curo Cubas Agustin, and Cortez Centeno Rosario Angelica. "Matemática Básica (Fds)-CE80-201501." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/637108.
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El curso tiene como finalidad consolidar en el alumno su formación en los conocimientos y principios básicos de la matemática en la educación superior dentro del marco de los valores principios y modelo educativo por competencias que rigen en la UPC para ello brinda al alumno el uso de sólidos conocimientos de lógica inferencial álgebra elemental y de funciones aritmética básica proporcionalidad porcentajes interés simple y compuesto ecuaciones lectura de gráficos y funciones que le permiten modelar plantear y resolver situaciones y/o problemas numéricos en contextos reales de su quehacer laboral. El curso se desarrollará a través de clases presenciales y virtuales donde se presentaran actividades controles material autónomo de trabajo casos prácticos videos y ejercicios aplicados a su realidad.
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Miguel, Curo Cubas Agustin, and Leva Apaza Antenor. "Matemática Básica (Fds)-CE80-201502." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/637109.
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El curso tiene como finalidad consolidar en el alumno su formación en los conocimientos y principios básicos de la matemática en la educación superior dentro del marco de los valores principios y modelo educativo por competencias que rigen en la UPC para ello brinda al alumno el uso de sólidos conocimientos de lógica inferencial álgebra elemental y de funciones aritmética básica proporcionalidad porcentajes interés simple y compuesto ecuaciones lectura de gráficos y funciones que le permiten modelar plantear y resolver situaciones y/o problemas numéricos en contextos reales de su quehacer laboral. El curso se desarrollará a través de clases presenciales y virtuales donde se presentaran actividades controles material autónomo de trabajo casos prácticos videos y ejercicios aplicados a su realidad.
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Ponce, Rodríguez Wilmer, Rucoba Gilber Piña, and de Castilla Vásquez Carlos López. "Estadística para Ingeniería 1 (CE54), ciclo 2013-1." Universidad Peruana de Ciencias Aplicadas - UPC, 2013. http://hdl.handle.net/10757/292962.
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Huamán, Enit, and Enver Tarazona. "Estadística para Ingeniería 2 (CE55), ciclo 2013-1." Universidad Peruana de Ciencias Aplicadas - UPC, 2013. http://hdl.handle.net/10757/292963.
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Bustamante, Bautista Beatriz. "Métodos Cuantitativos para los Negocios (MA109/CE30), ciclo 2013-1." Universidad Peruana de Ciencias Aplicadas - UPC, 2013. http://hdl.handle.net/10757/292939.
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Cuaderno de trabajo del Curso Métodos Cuantitativos (CE30) para el ciclo 2013-1. Al finalizar el curso, el alumno aplica instrumentos matemáticos como soporte al proceso de toma de decisiones en diferentes campos de los negocios (marketing, finanzas, logística y producción); siguiendo el proceso de modelación, cálculo, interpretación administrativa y análisis de sensibilidad.
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Bustamante, Bautista Beatriz. "Métodos Cuantitativos para los Negocios (MA109/CE30), ciclo 2014-1." Universidad Peruana de Ciencias Aplicadas - UPC, 2014. http://hdl.handle.net/10757/316021.
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Cuaderno de trabajo del curso Métodos Cuantitativos para los Negocios (MA109/CE30), que corresponde al semestre 2014-1. Al finalizar el curso, el alumno aplica instrumentos matemáticos como soporte al proceso de toma de decisiones en diferentes campos de los negocios (marketing, finanzas, logística y producción); siguiendo el proceso de modelación, cálculo, interpretación administrativa y análisis de sensibilidad. Los temas que se tratan son los siguientes: programación lineal, administración de proyectos, teoría de colas y decisiones bajo riesgo.
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Knauber, Tina. "Der Einfluss der stringenten Kontrolle auf die morphologische und physiologische Differenzierung in Sorangium cellulosum So ce56." Giessen VVB Laufersweiler, 2006. http://geb.uni-giessen.de/geb/volltexte/2006/2956/index.html.
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Al, Nussairi Alaa. "Characterising the static and impact load resistance of one-way RC slabs strengthened by NSM CFRP rods." Thesis, University of Bristol, 2018. http://hdl.handle.net/1983/3798ec86-ce52-4022-a27f-af94fbfb4a34.
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This study aims to enhance the blast resistance of reinforced concrete slabs which are commonly encountered in modern buildings. The focus is on preventing their collapse by increasing their ductility and energy dissipation by strengthening them with near surface mounted (NSM) carbon fibre reinforced polymer (CFRP) rods. Laboratory experiments were conducted to study the entire responses of one-way RC slabs with and without NSM CFRP strengthening with different loading rates (quasi-static and impact load). The quasi-static tests showed that strengthening both faces of the slab contributes to increasing the load capacity and ductility of the slab. In addition, the dissipated energy of the control slab was doubled in the strengthened slab. In the impact tests, the dissipated energy enhanced by a factor of 2.1 when only the compression face of the slab was strengthened by 7 CFRP bars. Also, applying the external strengthening technique led to a change in the crack pattern from one opened crack to multiple cracks in the tension face. Analytical and numerical models were also provided in this study to simulate the static and impact responses of the one-way NSM CFRP RC slabs. The analytical model was developed by modifying the traditional nonlinear layered analysis to incorporate CFRP bars and the various strain rate values. The modification in the nonlinear layered method comprised deriving and including the effect of the crack patterns on the entire response of the slabs, and combining a single-degree-of-freedom (SDOF) method to estimate the maximum response of the slab under blast and impact loads. The commercial software Abaqus was utilized in the numerical analysis. Results from both these models show a good agreement with the experimental results in terms of the entire load-deflection behaviour for both quasi-static and impact tests. The developed models were used to investigate the effects of the potential relevant factors on the entire response of the NSM CFRP system. The results show that the dissipated energy achieved by strengthening both faces of the slab depends on the ratio of the strengthening in each face, and the optimum dissipated energy was obtained when the CFRP in the tension face was allowed to rupture by increasing the CFRP strengthening ratio in the compression face if the shear resistance is controlled. The results also showed that the enhancing factor of the energy dissipation was almost strain rate independent.
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Wolff, Ingo Wilhelm. "The Last Glacial Maximum Patagonian Ice Sheet : a GIS-based high-resolution reconstruction approach." Thesis, Aberystwyth University, 2016. http://hdl.handle.net/2160/950c2c84-ce59-49f9-9946-19be41e9c750.
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The Last Glacial Maximum (LGM) Patagonian Ice Sheet (PIS) provides the unique potential to reconstruct the former meridional position and precipitation rates of the Southern Westerly Wind Belt (SWWB) due to its considerable latitudinal distance perpendicular to this global wind system. To use this potential, a high-resolution 3D reconstruction of the LGM PIS would be crucial, but knowledge about even the exact planform of this biggest Quaternary ice sheet on the Southern Hemisphere, excluding Antarctica, is still very poor. The widely accepted limits of the ‘Finiglacial’ ice sheet extent, mapped over 80 years ago by Caldenius (1932), has been identified as the LGM extent at many locations (e.g. Kaplan et al., 2004, 2008a,b; Singer et al., 2004; Hein et al., 2009). However, apart from the broadly correct assignation of the ‘Finiglacial’ limit to the LGM, its resolution remains poor, imperfect, and outdated, despite some later adaptations (e.g. Hollin and Schilling, 1981a; Clapperton, 1993) with small improvements. All attempts to provide 3D reconstructions (Hollin and Schilling, 1981a; Hulton et al., 1994, 2002) date back almost 15 years and did not match the poorly constrained glacial geomorphological record. This study presents a novel attempt to cast all relevant absolute dating locations of glacial landforms into a refined spatio-chronological context of the LGM extent of the PIS. Based on this newly set spatio-chronological context, a geographical information system (GIS)-based high-resolution LGM extent reconstruction, both in planform and in 3D, is presented within this study. In contrast to its predecessors, the applied GIS-based modelling approach enables a grade of reconstruction resolution for an ice sheet, that is as big as Spain and that is otherwise found only in local valley-scale glacier reconstructions. The spatial resolution of the GIS-based 3D ice-sheet reconstruction surface lies at 100 metres, as does the implemented topographic data. This leads to a spatial ice-sheet surface resolution that is at least 200 times higher than any previous attempt to cover the entire LGM PIS. The 3D reconstruction of the LGM PIS using the newly defined extent is in good agreement with observations on vertical ice extents (Boex et al., 2013) and displays, for the first time, a realistic interaction with the complex Patagonian topography. The area of the LGM PIS is, with ca. 504,500 km2 (±8.5%) roughly a fourth of the area of Greenland and represents 554,500 km3 (±10%) of ice or 1.38 metres (±10%) of sea-level equivalent. The now available 3D reconstruction provides a starting point that, after minor revisions, could potentially allow gauging accumulation rates along up to 2,300 km perpendicular to the SWWB and, thus, inferring valuable palaeo-climatic insights from the LGM.
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Fink, Robert D. "Evaluation of relational algebra queries on probabilistic databases : tractability and approximation." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b2188d19-ce55-44ae-bd20-7d50ea6f519b.
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Query processing is a core task in probabilistic databases: Given a query and a database that encodes uncertainty in data by means of probability distributions, the problem is to compute possible query answers together with their respective probabilities of being correct. This thesis advances the state of the art in two aspects of query processing in probabilistic databases: complexity analysis and query evaluation techniques. A dichotomy is established for non-repeating, con- junctive relational algebra queries with negation that separates #P-hard queries from those with PTIME data complexity. A framework for computing proba- bilities of relational algebra queries is presented; the probability computation algorithm is based on decomposition methods and provides exact answers in the case of exhaustive decompositions, or anytime approximate answers with absolute or relative error guarantees in the case of partial decompositions. The framework is extended to queries with aggregation operators. An experimental evaluation of the proposed algorithms’ implementations within the SPROUT query engine complements the theoretical results. The SPROUT2 system uses this query engine to compute answers to queries on uncertain, tabular Web data.
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Spencer, Justina. "Peeping in, peering out : monocularity and early modern vision." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:b8854565-ce57-4c83-9cdb-64249d171142.
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One of the central theoretical tenets of linear perspective is that it is based upon the idea of a monocular observer. Our lived perception, also referred to in the Renaissance as perspectiva naturalis, is always rooted in binocular vision, however, the guidelines for perspectiva artificialis often imply a single peeping eye as a starting point. In the early modern period, a number of rare art forms and instruments follow the prescriptive character of linear perspective to ludic ends. By focusing on this special class of what I would call 'monocular art forms', I will analyse the extent to which the perspectival method has been successfully applied in material form beyond the classic two-dimensional paintings. This special class of objects include: anamorphosis, peep-boxes, catoptrics, dioptric perspective tubes, and perspective instruments. It is my intention to draw attention to the different ways traditional perspectival paintings, exceptional cases such as perspective boxes and anamorphoses, and optical devices were encountered in the early modern period. In this thesis I will be examining the specific sites of each case study in depth so as to describe the various contexts - aristocratic, intellectual, religious - in which these items circulated. In Chapter 1 I illustrate a special class of perspective and anamorphic designs that confined their illusions to a peepshow. Chapter 2 examines one of the most consummate applications of the monocular principle of perspective: seventeenth-century Dutch perspective boxes. In Chapter 3, monocular catoptric designs are studied in light of the vogue for mirror cabinets in the seventeenth century. Chapter 4 examines the innovative techniques of drawing machines and their collection in early modern courts through close study of the 'perspectograph'.
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Songra, Goldie Tashfeen Butt. "A randomised controlled clinical trial to investigate the rates of alignment of the upper and lower labial segments, rates of extraction space closure in the upper and lower buccal segments and treatment efficiency using conventional, active and passive self-ligating orthodontic brackets." Thesis, University of Bristol, 2011. http://hdl.handle.net/1983/3bb4c926-ce51-4076-bf16-358aa97315b0.
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This study is composed of three parts. The principal aim was to compare the rate of alignment ofthe upper and lower labial segments using conventional Omni, active In- Ovation R and passive Damon 3MX self-ligating brackets. The second part of this study was to investigate the rate of extraction space closure in the buccal segments for all subjects. The third and final element of this study was to investigate the efficiency of treatment for all three bracket types. 100 eligible subjects undergoing upper and lower fixed appliance treatment with the loss of four premolars were randomly allocated to one of three treatment groups: conventional (Omni) n=20, active (In-Ovation R) n=38 or passive (Damon 3MX) n=42 self-ligating brackets. Study models were taken for all subjects at the start and at twelve week intervals until completion of treatment. The same archwire sequence was used in each case. The labial segment alignment of each study model was measured using a digital Vernier calliper and Little's Index of Irregularity. Once alignment was achieved, space closure was carried out using 150g NiTi coil springs and once again measured using a digital calliper. Analysis of data using linear mixed models demonstrated a significant effect of bracket type on the rate of alignment in the mandible (p=0.026), but not the maxilla (p=0.277). In the mandible, rate of alignment was significantly greater with conventional brackets (Omni). There was no significant difference between the two self-ligating brackets. The rate of space closure was significantly faster in males when compared with females for both the In-Ovation R (p=0.001) and the Omni brackets (p=0.003). This was also found to be the case for Damon 3MX brackets although this was not shown to be statistically significant. The results demonstrated a significant difference between the conventional and the two self- ligating brackets in relation to the total chair side treatment time, with the Omni bracket subjects total treatment time taking on average 50 minutes longer. They also showed a significant difference in the total number of appointments between the In-Ovation R and the Omni bracket (p=0.0009), with the In-Ovation R requiring fewer appointments. In all other analyses there were no significant differences.
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Ringle, Michael [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Charakterisierung ausgewählter Cytochrome P450 aus Sorangium cellulosum So ce56 : neue potentielle Biokatalysatoren / Michael Ringle. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1053724934/34.
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Ringle, Michael Verfasser], and Rita [Akademischer Betreuer] [Bernhardt. "Charakterisierung ausgewählter Cytochrome P450 aus Sorangium cellulosum So ce56 : neue potentielle Biokatalysatoren / Michael Ringle. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1053724934/34.
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Litzenburger, Martin [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Exploring the substrate range of selected myxobacterial cytochromes P450 from Sorangium cellulosum So ce56 / Martin Litzenburger. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1102196509/34.
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Packard, Barbara. "Remembering the First Crusade : Latin narrative histories 1099-c.1300." Thesis, Royal Holloway, University of London, 2011. http://repository.royalholloway.ac.uk/items/30bc10ac-ba25-0f0e-cef0-76af48433206/9/.
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The success of the First Crusade by the Christian armies caught the interest and arrested the imagination of contemporaries, stimulating the production of a large number of historical narratives. Four eyewitness accounts, as well as letters written by the crusaders to the West, were taken up by later authors, re-worked and re-fashioned into new narratives; a process which continued throughout the twelfth century and beyond. This thesis sets out to explore why contemporaries continued to write about the First Crusade in light of medieval attitudes towards the past, how authors constructed their narratives and how the crusade and the crusaders were remembered throughout the twelfth and thirteenth centuries. It will analyse the development in the way the First Crusade was recorded and investigate the social, religious, intellectual and political influences dictating change: How, why and under what circumstances was the story re- told? What changed in the re-telling? What ideas and concepts were the authors trying to communicate and what was their meaning for contemporaries? The thesis will also aim to place these texts not only in their historical but also in their literary contexts, analyse the literary traditions from which authors were writing, and consider the impact the crusade had on medieval literature. The focus will be on Latin histories of the First Crusade, especially those written in England and France, which produced the greatest number of narratives. Those written in the Levant, the subject of these histories, will also be discussed, as well as texts written in the Empire and in Italy.
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Hughes, Christopher William. "The effect of topography on ocean flow." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:37b3f6b2-ce5f-45b3-b2ed-3325518b06bb.
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The rôle which topography plays in constraining ocean flow is investigated in several ways, mostly aimed at application to the Southern Ocean where topography is known to be important. The physics of topographic Rossby waves is discussed in some depth and a description of ocean flow in terms of a sum of topographic normal modes is developed. It is shown that the apparent incompleteness of topographic modes can often be circumvented by including a function which absorbs the nett input of potential vorticity. Some subtle problems with this description are dealt with, and a calculation of topographic modes for the Southern Ocean is presented, which shows that the modes are very localised, making the use of them to describe basin-wide flows difficult. The effect of interactions between stratification and topography is investigated in terms of a quasi-two-dimensional model which deals only with the depth-integrated flow, and the assumptions which go into the model are examined in detail both analytically and by calculating terms of interest from a data set produced by the Fine Resolution Antarctic Model. It is shown that advection of density in the Southern Ocean can be described to a first approximation as being due to a barotropic current with no vertical velocity, the horizontal component of the baroclinic flow producing very little effect. The balance of terms reveals interesting features in the modelled flow in the Southern Ocean, showing the value of this type of analysis. Finally, insight developed in the course of the investigation allows a simple model to be constructed representing the feedback between density advection and forcing due to density gradients. This model is used to provide an explanation for the fact that the FRAM model spins up linearly, where most simple models would predict a component of quadratic behaviour in the spin-up.
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Lau, Aaron. "Oxidation of soot with modified silver catalysts." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:138e06c2-ce59-4754-a71a-d2dc0c52ecbe.
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As the demand for motor vehicles has soared dramatically with the emergence of rapidly developing countries, the need for regulating vehicle emissions and pollutants is increasingly more important. With the newest regulations for diesel particulate emissions soon to be enforced, there is a great need to catalytically convert soot particles from the exhaust into relatively less polluting carbon dioxide. Here a supported silver catalyst is reported for the soot oxidation reaction. The silver catalyst is protected and supported using various capping agents and metal oxides, and modified using various synthetic methods. The catalysts are then tested with soot using thermogravimetric analysis (TGA) at a reaction temperature up to 700oC. In order for a better design and modification of the silver catalyst, an improved understanding of the interaction between silver nanoclusters and the metal oxide support must be established. XPS and UV/VIS spectroscopy are amongst the techniques used to probe the metal/metal oxide interaction. It is shown that the surface plasmon resonance of silver can be perturbed by the metal oxide support, modifying its band structure. It is also extremely important for the catalyst to be thermally stable up to 600°C for it to be employable in an exhaust system. In-situ XRD can be used to investigate the thermal stability of both the silver and metal oxide species in an oxidising environment. The phase changes, if any, of either species under heating can also provide a better understanding of the metal/metal oxide interaction and ultimately the soot combustion mechanism. It has been demonstrated that different catalyst surfaces can have different catalytic performances. By altering the morphology of the support, preferential growth of one surface can be achieved, thereby modifying the catalytic performance for soot combustion.
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Ko, Hsiang-Shang. "Analysis and synthesis of inductive families." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2bc39bde-ce59-4a49-b499-3afdf174bbab.
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Based on a natural unification of logic and computation, Martin-Löf’s intuitionistic type theory can be regarded simultaneously as a computationally meaningful higher-order logic system and an expressively typed functional programming language, in which proofs and programs are treated as the same entities. Two modes of programming can then be distinguished: in externalism, we construct a program separately from its correctness proof with respect to a given specification, whereas in internalism, we encode the specification in a sophisticated type such that any program inhabiting the type also encodes a correctness proof, and we can use type information as a guidance on program construction. Internalism is particularly effective in the presence of inductive families, whose design can have a strong influence on program structure. Techniques and mechanisms for facilitating internalist programming are still lacking, however. This dissertation proposes that internalist programming can be facilitated by exploiting an interconnection between internalism and externalism, expressed as isomorphisms between inductive families into which data structure invariants are encoded and their simpler variants paired with predicates expressing those invariants. The interconnection has two directions: one analysing inductive families into simpler variants and predicates, and the other synthesising inductive families from simpler variants and specific predicates. They respectively give rise to two applications, one achieving a modular structure of internalist libraries, and the other bridging internalist programming with relational specifications and program derivation. The datatype-generic mechanisms supporting the applications are based on McBride’s ornaments. Theoretically, the key ornamental constructs — parallel composition of ornaments and relational algebraic ornamentation — are further characterised in terms of lightweight category theory. Most of the results are completely formalised in the Agda programming language.
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Knauber, Tina [Verfasser]. "Der Einfluss der stringenten Kontrolle auf die morphologische und physiologische Differenzierung in Sorangium cellulosum So ce56 / vorgelegt von Tina Knauber." Wettenberg : VVB Laufersweiler, 2006. http://d-nb.info/981070213/34.
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Schifrin, Alexander [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Charakterisierung von Sesquiterpenen und der an deren Biosynthesen beteiligten Gene des Myxobakteriums Sorangium Cellulosum So ce56 / Alexander Schifrin ; Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1137509503/34.
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Bellon, Olivier. "Comparison of ZrO2 and Ce02 based SOFC tubular electrolytes prepared by the colloidal suspension route." Thesis, Keele University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302276.
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Coutant, Anthony. "Modèles Relationnels Probabilistes et Incertitude de Références : Apprentissage de structure avec algorithmes de partitionnement." Nantes, 2015. http://archive.bu.univ-nantes.fr/pollux/show.action?id=e9a2bfb8-cea0-4ce5-91a0-6b48cae0e909.
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Nous sommes entourés de données hétérogènes et interdépendantes. L’hypothèse i. I. D. A montré ses limites dans les algorithmes considérant des jeux de données tabulaires, constitués d’individus dotés du même domaine de définition et sans influence mutuelle. L’apprentissage relationnel statistique a pour objectif la représentation de connaissances, le raisonnement et l’apprentissage dans des contextes de jeux de données multi relationnels avec incertitude et les modèles graphiques probabilistes de second ordre sont une solution pour l’apprentissage génératif dans ce contexte. Nous étudions dans cette thèse un type de modèles graphiques probabilistes de second ordre dirigés, appelés modèles relationnels probabilistes, dans un contexte d’incertitude de références, c. -à-d. Où les individus d’un jeu de données peuvent présenter à la fois une incertitude sur la valeurs de leurs attributs descriptifs, et sur leurs implications dans des associations avec d’autres individus, et ayant la particularité de s’appuyer sur des fonctions de partitionnement des individus pour découvrir des connaissances générales. Nous présentons les limites des modèles existant pour l’apprentissage dans ce contexte et proposons des extensions présentant l’intérêt de pouvoir utiliser des méthodes de partitionnement relationnel, plus adaptées au problème, et proposant un biais de représentation simplifié autorisant la découverte de connaissances supplémentaires, notamment entre les différents typWe are surrounded by heterogeneous and interdependent data. The i. I. D. Assumption has shown its limits in the algorithms considering tabular datasets, containing individuals with same data domain and without mutual influence on each other. Statistical relational learning aims at representing knowledge, reasoning, and learning in multi-relational datasets with uncertainty and lifted probabilistic graphical models offer a solution for generative learning in this context. We study in this thesis a type of directed lifted graphical model, called probabilistic relational models, in the context of reference uncertainty, i. E. Where dataset’s individuals can have uncertainty over both their internal attributes description and their external memberships in associations with others, having the particularity of relying on individuals partitioning functions in order to find out general knowledge. We show existing models’ limits for learning in this context and propose extensions allowing to use relational clustering methods, more adequate for the problem, and offering a less constrained representation bias permitting extra knowledge discovery, especially between associations types in the relational data domain
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Yuan, Yi. "Torque ripple reduction in a permanent magnet synchronous machine using repetitive control techniques (Drift)." Nantes, 2014. http://archive.bu.univ-nantes.fr/pollux/show.action?id=d81a622d-ce54-4be1-8bed-491ba10fa201.
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Les machines synchrones à aimants permanents (MSAP) sont de plus en plus utilisées dans de nombreuses applications grâce à leur efficacité, fiabilité et performances. Cependant, les oscillations de couple peuvent provoquer des oscillations de la vitesse qui sont considérées comme un problème majeur dans certaines applications à faible vitesse. Par conséquent, la commande répétitive (CR) est choisie pour sa forte capacité à réduire ces perturbations périodiques et réduire les oscillations de couple. Il existe deux problèmes principaux lors de l’application de la CR à une MSAP. D’abord, la CR ne peut réaliser la réduction souhaitée que dans le cas d’une vitesse constante. Grâce à la relation fixe entre ces oscillations et la position du rotor, nous proposons de prendre l’angle mécanique comme la nouvelle variable du fonctionnement de la CR. Ce nouveau régulateur est appelé régulateur répétitif basé sur la position angulaire. L’avantage de ce contrôleur est sa capacité de réduction même dans le cas d’une vitesse variable. Le deuxième inconvénient de l’application de la CR est sa difficulté d’implantation dans les systèmes industriels. Ainsi, nous proposons d’ajouter le contrôleur répétitif dans un capteur de vitesse et de développer une nouvelle technique appelée capteur répétitif intelligent. Avec ce capteur, l’application de la technique de CR ne requiert aucune modification du contrôleur, mais il est nécessaire de remplacer le capteur normal par le capteur répétitif intelligent. Finalement, ces deux nouvelles techniques sont réalisées ensemble sur un banc d’essais et leur efficacité est validée par des résultats expérimentauxPermanent magnet synchronous machines (PMSMs), due to their attractive efficiency, reliability and performance, are rapidly gaining popularity in many applications. However, torque ripples of PMSM generally cause speed ripples, which are considered as an important hindrance in some low speed applications. The repetitive control (RC), which is particularly suitable for the reduction of periodic disturbance, is chosen to achieve the torque ripple reduction, because torque ripples of PMSM can be considered as periodic disturbances. The use of the RC for machine torque ripple reduction is not new. However, the reduction is always achieved at a given speed. This is due to the nature of the RC. So as to extend the use of the RC to varying speeds, the angle-based RC technique, which takes the mechanical angle as the running variable, is considered in this work. Thanks to the fixed relationships between the torque ripples and the mechanical angle, the angle-based repetitive controller can keep its rejection capability, whether the speed is constant or not. Besides, applying the RC in a PMSM drive requires to implement a new controller, which is hardly achievable for commercial systems. In order to apply the RC for PMSM drives, this paper proposes to include the RC into a speed sensor, forming a particular speed sensor called repetitive smart sensor. Accordingly, the torque ripple reduction can simply be accomplished by changing a conventional speed sensor for a repetitive smart one. Finally, the efficiency of the proposed angle-based repetitive smart sensor is verified through experimental results
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Khatri, Yogan [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "The cytochrome P450 complement of the myxobacterium Sorangium cellulosum So ce56 and characterization of two members, CYP109D1 and CYP260A1 / Yogan Khatri. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2010. http://d-nb.info/1052338755/34.
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Ly, Thuy Thi Bich [Verfasser], and Rita [Akademischer Betreuer] Bernhardt. "Characterization of CYP264B1 and a terpene cyclase of a terpene biosynthesis gene cluster from the myxobacterium Sorangium cellulosum So ce56 / Thuy Thi Bich Ly. Betreuer: Rita Bernhardt." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1057789291/34.
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Chan, Ka Shun. "A post make-believe definition of fiction." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/a-post-makebelieve-definition-of-fiction(633d7954-ce40-4057-8717-9ffb5ec76bae).html.
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The question of what exactly constitutes a work of fiction has been contested for decades, with no clear conclusion. While there are several factions of philosophers, each with their preferred definitions, none are widely accepted definitions. Most, when used, often include some works of nonfiction as works of fiction, or exclude some works that are clearly works of fiction. In this thesis, I will use an interdisciplinary methodology to provide a new definition of fiction that avoids these pitfalls. In Chapters 1 and 2, I show that it is implausible to take propositional imagination as a necessary component of a definition of fiction without any further clarification of the role of make-believe imagination in fiction and that a plausible definition of fiction should not include the role of the audience. In Chapter 3, I evaluate Stacie Friend’s genre approach, as probably the most popu-lar non-make-believe approach. In Chapter 4, I cover Harry Deutsch’s often-ignored approach, discuss its problems, and outline its contributions. In Chapter 5, I reject Matravers’s scepticism by showing that there is a meaningful difference between fiction and nonfiction using the findings from social science experiments. In Chapter 6, I construct my own definition of fiction by interpreting the findings from in Chapter 5 along with the concepts of interior properties, phenomenal con-cept, and end value. I then address the issue of assertions in fiction, why it is such a problem for many existing definitions, and how it can be overcome by my defini-tion. In Chapter 7, I discuss miscellaneous issues that arise in defining fiction, address them using my definition, and how my account complements an iconic theory in a related debate. In Chapter 8, I conclude the work with an overview of what I have argued, my defi-nition of fiction, and how I have contributed to several philosophical debates.
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Reardon, Mark. "The ethics of animal advocacy : towards biocentric individualism." Thesis, University of South Wales, 2011. https://pure.southwales.ac.uk/en/studentthesis/the-ethics-of-animal-advocacy-towards-biocentric-individualism(a913635a-ced0-4029-8820-12106dbff5e2).html.
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The contemporary animal rights movement, in extending moral consideration to nonhuman animals, has in diverse ways already contributed to an expansion of the boundaries of the ethical community and what that may constitute. However, many environmentalists argue there is a failure within animal ethics to adequately address wider animal advocacy concerns, and that consideration of broader ecosystemic challenges elicit at best moot response from mainstream animal rights advocates. In taking an individualistically based biocentric approach, the essential aims of animal ethics can, I argue, be readily embraced into a theory of value that can address this wider remit. In aligning the applicability of a developed form of biocentric individualism with the ethical underpinning of notions of the 'illegitimacy of animal use' extrapolated from normative animal advocacy perspectives, my proposition is that these shortcomings can be ameliorated and that such an alignment forms a complimentary and useful fusion. Biocentrism as a value theory asks for moral considerability to be centred upon a respect for individual nonhuman (and human) life and the possession/continuation of a flourishing individual life - neither of which, I contend, is at odds with the essential spirit of animal ethics. In this sense, I submit that a developed biocentric individualism 'bridges the gap' between animal ethics and environmental ethics.
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Al, Barrak Thamir. "Value relevance and predictive ability of financial statement information : the case of Saudi Arabia." Thesis, University of Portsmouth, 2011. https://researchportal.port.ac.uk/portal/en/theses/value-relevance-and-predictive-ability-of-financial-statement-information(e1269ccc-ce55-4761-9c48-f00e9c245d16).html.
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The Saudi financial reporting environment witnessed significant development in the past two decades, which is evidenced by the incorporation of the Saudi accounting standard setter (Saudi Organization for Certified Public Accountants (SOCPA)) and its subsequent development of the accounting profession. The main objective of this study is to investigate whether developments in financial reporting following SOCPA’s inception resulted in financial statement information being more value relevant over time. This study focuses solely on quantitative methods and employs secondary data in addressing the research questions. This study uses adjusted R² as a primary metric for measuring value relevance. Value relevance of accounting information has been investigated through its association with contemporaneous market values and future cash flow-predictive ability studies. The theoretical frameworks of Ohlson (1995)and Easton and Harris (1991) have been used to specify the relationship between accounting information and market values. To link accrual-based earnings and accrual components with future cash flows, the theoretical frameworks of Dechow, Kothari and Watts (1998) and Barth, Cram and Nelson (2001) have been used. A sample of firms listed in the Saudi Stock Market during the 1993–2009 time period has been used. The total number of observations included in the sample is 997 from 97 firms, which excludes firms in the banking and insurance sectors. The main findings of the value relevance of accounting information in equity valuation are: First, earning (book value) coefficients were found to be significant in (nine) all years in the price regressions. Second, earning levels and changes have not been found significantly related to stock returns in all years. Third, hedge portfolio strategies based on pre-knowledge of accounting information yielded non-zero returns. Fourth, the explanatory power of the price model increased from the 1993–1997 to the 1998–2003 time period and declined in the following time period. Fifth, the explanatory power of the return model shows no significant change over time. Sixth, earnings are not value-relevant in equity valuation for loss-making firms, while book value is value-relevant for the 1993–1997 and 1998–2004 time periods. Earnings are only asymmetrically timely in reflecting good and bad news in the 1998–2003 and 2004–2009 time periods. Findings from the predictive ability of future cash flows show that earnings provide incremental explanatory power beyond that provided by current cash flows in all three pooled cross sections. Earnings’ accrual components have also been found been found to significantly provide incremental explanatory power beyond that provided by current cash flows in predicting future cash flows. These two measures did not witness any significant change over time. Earnings as a summary measure have not been found to outperform current cash flows in their predictive ability except for three years. This study concludes that accounting information has been value relevant during the entire period of this study and that an increase in value relevance might only be present in the early period of this sample.
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Harries, Matthew Edward. "The role of Article VI in debates about the nuclear Non-Proliferation Treaty." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-article-vi-in-debates-about-the-nuclear-nonproliferation-treaty(63e6f120-ce80-40df-a3f0-3ab2e8a8f12c).html.
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This thesis examines the role that nuclear disarmament, embodied in the Article VI obligation, has played in debates about the Non-Proliferation Treaty. It provides a narrative archival history of the treaty negotiations, tracing the emergence of the NPT idea as the key priority for multilateral nuclear diplomacy in the mid-1960s, describing the tortuous route to superpower agreement on pursuing an NPT; and exploring the complex process by which key US allies and non-aligned states were encouraged to support the treaty. On this basis the thesis explains the role that disarmament played in conceiving, lobbying for and achieving an NPT. The thesis goes on to outline how the role of disarmament in the NPT 'bargain' has evolved, beginning with the effects of US ambivalence about the NPT in its early years, and the development of a circumscribed process of arms control. It then traces a path from the treaty's first review conference in 1975 up to the acrimonious failure of 2005. Finally, it provides an assessment of the role that disarmament issues played in the 2010 NPT Review Conference, which the author attended. The thesis argues, firstly, that the role of disarmament in the original NPT ‘bargain’ was limited and left key questions unsettled, but was nonetheless highly significant in political terms. Secondly, it explains how the practice of a distinctive ‘NPT diplomacy’ allowed the treaty to form the basis of a broader non-proliferation regime. Lastly, however, it concludes that the unresolved questions inherent in Article VI, and exacerbated since the end of the Cold War, mean that the NPT is unlikely to act as an effective vehicle to achieve the vision of a world free of nuclear weapons, and that measures to strengthen the non-proliferation regime in the future are unlikely to be achieved by offering specific concessions on disarmament.
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James, Karen Anne. "The characteristics of inpatient self harm, and the perceptions of nursing staff." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/the-characteristics-of-inpatient-self-harm-and-the-perceptions-of-nursing-staff(075056bc-ce5d-4635-93d6-86c9f2502150).html.
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Background: Self harm is an increasingly common behaviour, associated with poor mental health, and an increased risk of death by suicide and other causes. It is one of the principle reasons for admission to inpatient psychiatric services, however very little is known about self harm on wards. Aims: This thesis set out to address a number of gaps in the literature identified following a systematic review of studies of inpatient self harm. Main aims were to describe the characteristics of self harming behaviour within a national sample of services, and to investigate perceptions of self harm and views of harm minimisation practices amongst inpatient nursing staff. Methods: Aims were addressed in two studies using a mixed methods approach. Study 1 investigated the characteristics of self harming behaviour within inpatient mental health services across the UK, through a cross-sectional documentary analysis of incident reports. Study 2 was a sequential explanatory study of nursing staff attitudes towards self harm, composed of two phases; Phase I measured staff attitudes and their relationship to staff characteristics, using the Self Harm Antipathy Scale, and Phase II was a qualitative interview study of staff understandings of self harm. Results: Inpatient self harm was more frequent within acute vs forensic services, largely took place in the private areas of the ward, during the evening hours, and constituted a wide range of behaviours of which cutting was the most common. Inpatient nursing staff generally demonstrated positive attitudes towards self harm, however being a healthcare assistant, or from a non-white ethnic group were associated with more negative attitudes, as were lower SF-36 scores. Staff differentiated between acts of ‘self harm’ and ‘attempted suicide’ using a wide range of criteria which differed between individual participants. Views of harm minimisation practices were mixed. Conclusions: Specialist training in mental health would be beneficial to all practitioners working with people who self harm, and should particularly focus on the interpersonal reasons for self harm. Amongst culturally diverse teams of staff there are likely to be multiple understandings of self harm, and those from high religiosity minority ethnic backgrounds may be less accepting of the behaviour. Use of the term ‘attempted suicide’ is problematic and should be avoided. A harm minimisation approach, whilst potentially beneficial to service users, will present significant challenges to some nursing staff.
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Mclachlan, David. "A critical examination of the interaction of disability theology and ideas of atonement." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/a-critical-examination-of-the-interaction-of-disability-theology-and-ideas-of-atonement(a3136aab-ce53-45b4-b40d-a2351d452574).html.
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This thesis brings together two fields of theological ideas. On the one hand, at the heart of Christian theology and faith are the person and work of Jesus Christ, centred on God's initiative of Atonement through the cross. Here God addresses the whole condition of creation and humanity, usually expressed in terms of dealing with sin. On the other hand, the growing field of Christian disability theology is seeking a positive theological account of disability, viewing it as an integral part of the variety of humanity, and resisting normate assumptions that cast what is regarded as disability in a wholly negative light. Drawing these fields together, does the way we think about the Atonement, and what God addresses and achieves through the Atonement, need to be disrupted and re-formed in light of the insights of disability theology? Conversely, if disability theology is to be distinctively Christian, should the Atonement play a far more foundational role within it than it has to date? If so, given the often negative juxtaposition of disability and sin within theology and in biblical texts, how is all this to come about? The approach taken is first to examine both of these fields and the extent of their current interaction. In particular, their use of ideas and metaphor are explored, to determine whether these provide the means for making that interaction more fruitful. However, the interaction is found to be partial at best, and the ideas and metaphors shared are not found to provide the means for the task at hand. Based on that work, however, a proposal is developed for reconsidering what sort of event the Atonement is, and the nature of God's presence within it. Building on insights from Frances Young, Jurgen Moltmann, Eberhard Jungel and Paul Fiddes, it is proposed that the Atonement should be understood as God's deepest, once for all participation in the risk (both moral and contingent) of creation, through which all that alienates us from God and each other is addressed. This opens up a theological space to talk of disability, sin and the cross together, one that does not require all aspects of what we identify as disability to fit into a binary sin/not sin analysis. This Atonement-as-participation also provides an account of the Atonement that is inherently inclusive of humanity in all its variety, where disability is not a special case. This enables God's initiative of the Atonement to function as a foundation for the various themes within disability theology as these continue to develop.
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Scott, Gillian Anne. "Contemporary ecology and stable isotope geochemistry of benthic foraminiferids in the Celtic Sea." Thesis, Bangor University, 1998. https://research.bangor.ac.uk/portal/en/theses/contemporary-ecology-and-stable-isotope-geochemistry-of-benthic-foraminiferids-in-the-celtic-sea(ed14ac68-ce51-4156-8420-773fee552fb7).html.
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The primary aim of this thesis was to assess the value of foraminifera in downcore studies of shelfsea stratification using both assemblage and geochemical characteristics. An examination of the modern distribution of foraminifera in the context of stratification in the Celtic Sea and comparison of these distributions with measured environmental variables was undertaken to this end. In addition, several species were examined for their stable oxygen and carbon isotopic composition with reference to the ambient bottom and porewaters. Cruises were run to the Celtic Sea in July, 1995 and July-August, 1996, during which hydrographic data, water and surface sediment samples were collected from 138 stations. Fifty-three samples were subsequently analysed for grainsize, geochernical and foraminiferal properties, while the water samples were analysed for oxygen isotopic composition. A total of six multicores were extracted and sectioned. Each section was analysed for porewater carbon isotopic composition and foraminiferal content. Selected foraminifera from both the surface and subsurface samples were analysed for the oxygen and carbon isotopic composition of their test calcite. Statistical analyses of the foraminiferal data indentifed four distinct assemblages which have potential for palaeostratification studies. The mixed-type assemblage included Cibicides lobatulus, Ammonia beccarfi, Quinqueloculina seminulum, Textularia bockii and Spiroplectammina, wrightfi. The stratifiedtype assemblages included Bulimina marginata, Hyalinea balthica, Nonionella turgida and Adercotryma glomeratum while Stainforthis fusiformis was diagnostic of the front. Bulimina gibba, Elphidium excavatum forma selseyensis and Eggerelloides scabrus defined an eastern asseblage. It is believed that the true controls on these assemblages are oxygen and food supply. Ammonia beccarii precipitated its test in oxygen isotopic equilibrium while Q. seminulum was consistently, negatively offset by approximately 0.5 O/oo. This demonstrates the potential of these species in palaeo-temperature and particularily, palaeo-stratifcation studies. The 'microhabitat effect' was examined for several species of foraminifera but was not observed.
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Thomas, Garry. "A critical analysis of the use of community intelligence in local neighbourhood policing in South Wales." Thesis, University of South Wales, 2014. https://pure.southwales.ac.uk/en/studentthesis/a-critical-analysis-of-the-use-of-community-intelligence-in-local-neighbourhood-policing-in-south-wales(22f48737-ce51-4e95-8c32-b76b0b97eaec).html.
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This research critically analyses the use of community intelligence in the delivery of local neighbourhood policing in South Wales and the police service in general. It examines in detail the development of policing and intelligence, particularly neighbourhood policing and community intelligence from its early beginnings and evaluates the contemporary definitions and police officer and staff perceptions of neighbourhood policing and community intelligence. This research also proposes a new definition of community intelligence and analyses how community intelligence is gathered, recorded and processed, and its relationship to the Intelligence Cycle and the National Intelligence Model. It further examines the operational application of community intelligence, including in counter terrorism and tackling organised crime, and the competing priorities, tensions and contradictions between performance management, neighbourhood policing, problem-oriented policing and intelligence-led policing. This research also evaluates the decision making process and how that may be affected by organisational issues such as, organisational culture, behaviour, management, leadership, information and knowledge. It examines the importance of community engagement in developing community intelligence and providing cohesive policing services to the public. Furthermore, this research considers the future directions of community intelligence and research on policing. The findings from this research indicate that some community intelligence is used to direct policing patrols and operations. However, there is some confusion by police officers and staff as to what constitutes community information and intelligence and thus it is not always recorded correctly limiting its use in the delivery of local neighbourhood policing and resulting in the loss of intelligence. This serves to highlight some of the areas for improvement in the policies, procedures, systems and management of intelligence. The findings also indicate the potential use of community intelligence in counter terrorism and in the provision of improved policing services to the public.
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Tiwari, Sachin Suresh. "A study of putative p25 modulated synaptic molecules - CYFIP1, CYFIP2 and CSPα - in Alzheimer's disease." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/a-study-of-putative-p25-modulated-synaptic-molecules--cyfip1-cyfip2-and-csp--in-alzheimers-disease(2a989df1-ced0-4707-bfc7-4df22ca9fff4).html.
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Alzheimer’s Disease (AD) is a devastating neurodegenerative condition with synaptic impairment at the onset of disease. Previously, our group have shown that the p25 molecule is changed in the post mortem brain of mild stage AD patients. A mass spectrometric analysis of p25 transgenic mouse brain provided us with a set of potential p25 downstream molecules. Three of these candidate molecules which had synaptic/dendritic localization – CYFIP2, CYFIP1 and CSPα were selected to be studied in the post-mortem brain of Alzheimer’s patients. CYFIP2 is a dendritically localised molecule with biological role in local translation modulation and cytoskeleton remodelling. Our case –control studies revealed that CYFIP2 is downregulated in severe stages of disease in hippocampus. We showed a similar CYFIP2 downregulation in Tg2576 mouse model of AD. We performed functional studies of this molecule, using CYFIP2 heterozygous knockout mice. We found that these mutants suffer from memory loss after Pavlovian conditioning. CYFIP1 has similar cellular function as CYFIP2. Our studies showed that CYFIP1 is upregulated in AD hippocampus. However, this upregulation is unlikely to be compensation for CYFIP2 downregulation, as it was not observed in superior temporal gyrus. CSPα, a synaptic vesicle protein that has been implicated in neurodegeneration in Kufs disease, was found to be downregulated in AD hippocampus, but, surprisingly, upregulated in cerebellum. This suggests that CSPα may protect neurons from degeneration. In agreement, we found that CSPα upregulation in htau mutant mice correlates with absence of neuronal loss. Taken together, analysis of candidate p25-regulated synaptic proteins have provided novel insights into mechanisms underlying synaptic degeneration and memory impairment in AD.
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Morales, Gomez Ana Ivon. "Individual and structural factors affecting recidivism : the role of prisoners, prisons and place in the Chilean context." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/individual-and-structural-factors-affecting-recidivism-the-role-of-prisoners-prisons-and-place-in-the-chilean-context(8edcc030-ce5d-4497-acac-3e4d56ed4421).html.
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Criminology has a long history of trying to understand why people reoffend. People that are released from prison offer us the opportunity study the conditions under which some individuals continue to commit crimes and others do not in great detail. Although research in the last years have incorporated the context as a source of influence on recidivism, much of the literature has focused on attributing the explanations solely on the level of the individuals themselves. Taking this individualistic perspective as my point of departure, I take some steps towards incorporating effects of the environment and aspects associated with social influence and learning in explaining why people re-offend (after being released from prisons). Studying the Chilean prison system, I first establish individual factors associated with recidivism, then account for prison environment and characteristics, to finally attempt at accounting for larger community effects. This was done by analysing data from a cohort of offenders who served sentences in Chilean prisons. Individual factors associated with time until recidivism were analysed using Event history models. Then, multilevel models were used to account for prison-specific effects: the exclusive contribution of prison to recidivism. Finally, hierarchical spatial models were used to analyse how space can be associated with varying levels of recidivism. In addition to the effects of individual characteristics, strong evidence of prison-specific effects was found, which implies that individual propensity towards recidivism is not independent of the prison where the sentence is served. In other words, differences in prison settings have the potential to impact on the individual likelihood of re-offending either by reducing or incrementing the individual risk. Likewise, evidence of spatial clustering of recidivism was also found, which indicates that recidivism has also a spatial component operating beyond the individuals' control. The main contribution of this thesis lies in demonstrating that recidivism implies a complex system of interdependence between different actors and institutions, which needs to be considered to understand recidivism in a larger context. These findings have profound theoretical and policy implications, as they imply that the responsibility for recidivism falls not only on the offenders themselves but also on the wider context of the justice system's institutions and society itself.
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Darley, Sarah. "Expansive and transformative learning within volunteer training : a multiple case study of three UK health and social care charities." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/expansive-and-transformative-learning-within-volunteer-training-a-multiple-case-study-of-three-uk-health-and-social-care-charities(0107808d-ce40-4c9d-bc55-ecb19627b907).html.
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This research explores the learning of volunteers who are being trained to perform service-providing roles within UK health and social care charities. Within these charities, volunteers often perform complex roles in dynamic environments, supporting service users and addressing challenging causes. This thesis argues that the charity and voluntary environment offers certain affordances, and also constraints, that provide opportunities for transformative learning experiences. The limited previous studies on the learning of volunteers have tended to concentrate on training evaluations or informal learning 'on the job', resulting in an unhelpful formal/informal dichotomised approach to learning. The research proposes that this approach has been unable to offer a detailed insight into the learning experienced by volunteers within the training process. In particular, this dichotomised view has been unable to account for both the learning of scientific concepts, such as the specific health conditions these charities are addressing, and everyday experiences of both volunteers and service users that are integral to the learning process. To address this gap, the thesis draws upon Cultural-Historical Activity Theory (CHAT), which is an approach grounded in Hegelian dialectics. Specifically, the CHAT-informed theories of expansive learning (Engeström, 1987) and Transformative Activist Stance (TAS) (Stetsenko, 2008) are synthesised to examine how volunteers interact with and within the charity environment through practices of training. Through this perspective, learning is conceptualised as a form of individual and social transformation, which expands the possibilities for collective activity. Expansive learning and TAS have previously been drawn upon to provide insight into learning in the workplace and in projects of social change respectively. However, so far the theories have not been focused on learning within the charity and voluntary environment. A multiple case study of three health and social care charities based in North West England provides the empirical data for the research. Each charity addresses a complex health and social cause, including stroke, sexual violence and HIV, and relies on volunteers to help provide services. Multiple qualitative methods, including observations of training, charity staff interviews, along with interviews and focus groups with volunteers, allow a range of perspectives and positions to be taken into account in line with the epistemology of the study. Data are analysed through the process of abduction drawing upon a CHAT-informed theoretical framework. The thesis intends to contribute to knowledge in two main areas. Firstly, it aims to increase understanding of learning within volunteer training, including how learning in the charity environment can be supported, sustained and made meaningful to enable transformative experiences. Secondly, it aims to theoretically advance CHAT, and the charity and voluntary environment is presented as a fruitful setting for developing particular aspects of the theory, such as emotion and agency.
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Binti, Mohamad Noor Shafini. "Impact of P2RX7 purinoceptor ablation on the morphometric, mechanical and tissue properties in the murine model of Duchenne muscular dystrophy." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/impact-of-p2rx7-purinoceptor-ablation-on-the-morphometric-mechanical-and-tissue-properties-in-the-murine-model-of-duchenne-muscular-dystrophy(60c82bbf-ce54-4054-aa0e-31a39affbd7c).html.
Full textAbstract:
Duchenne muscular dystrophy (DMD) is an inherited, lethal disorder characterised by progressive muscle degeneration and associated bone abnormalities. It has previously demonstrated that P2RX7, a purinergic receptor, contributed to the pathogenesis of DMD, and found that P2RX7 ablation alleviated the severity of the disease. In this work a dystrophic mdx mouse crossed with the global P2RX7 receptor has been used to generate a knockout mouse model (mdx/P2X7-/-), and compared its morphometric, mechanical and tissue properties against those of mdx,a mouse model without the dystrophin protein, as well as a wild type (WT) and aP2RX7 knockout (P2X7-/-). Micro-computed tomography (μCT), three-point bending testing, scanning electron microscopy (SEM) and nanoindentation were utilised in the study. The bones were analysed at approximately 4 weeks of age to examine the impact of P2RX7 ablation on the bone properties during the acute disease phase, before muscle wasting is fully developed. The results show that P2RX7 purinoceptor ablation has produced improvement or significant improvement in some of the morphological, mechanical and tissue properties of the dystrophic bones examined. Specifically, although the ablation produced smaller bones with significantly lower total cross-section area (Tt.Ar) and Second Moment of Area (SMA), significantly higher cortical bone area (Ct.Ar),cortical bone area ratio (Ct.Ar/Tt.Ar) and trabecular bone volume fraction (BV/TV)are found in the mdx/P2X7-/- mice than in any other types. Further, the mdx/P2X7-/- bones have relatively higher average flexural strength, work-to-fracture and significantly higher strain to failure compared with those of mdx, suggesting greater resistance to fracture. Indentation modulus, elasticity and creep are also significantly improved in the knockout cortical bones over those of mdx. These findings seem to suggest that specific pharmacological blockade of P2RX7 may improve dystrophic bones, with a potential for therapeutic application in the treatment of the disease.
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Alici, Aysel [Verfasser]. "Comprehensive proteomics of Sorangium cellulosum So ce56 / by Aysel Alici." 2007. http://d-nb.info/987649191/34.
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Knauber, Jens Michael. "Untersuchungen zum genetischen Potential der Sekundärstoffbildung von Sorangium cellulosum So ce90 und Identifizierung des Spirangienbiosynthesegenclusters /." 2005. http://www.gbv.de/dms/bs/toc/478450451.pdf.
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Ewen, Kerstin Maria [Verfasser]. "In-vitro-Untersuchung potentieller Ferredoxine und Ferredoxin-Reduktasen des Myxobakteriums Sorangium cellulosum So ce56 / von Kerstin Maria Ewen." 2009. http://d-nb.info/1010444697/34.
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Knauber, Jens Michael [Verfasser]. "Untersuchungen zum genetischen Potential der Sekundärstoffbildung von Sorangium cellulosum So ce90 und Identifizierung des Spirangienbiosynthesegenclusters / von Jens Michael Knauber." 2005. http://d-nb.info/97394711X/34.
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Doß, Sabrina Désirée [Verfasser]. "Analyse der morphologischen und physiologischen Differenzierung in Sorangium cellulosum So ce56 : Lon-Proteasen und Stickstoffmetabolismus / vorgelegt von Sabrina Désirée Do." 2007. http://d-nb.info/985904291/34.
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