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Journal articles on the topic 'Cecum mass'
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Bazeliuc, Iurii, and Alin Bour. "THE RARE PATHOLOGY OF THE CECUM. LITERATURE REVIEW." Arta Medica 84, no. 3 (2022): 46–52. https://doi.org/10.5281/zenodo.7306049.
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<strong>Objectives</strong>. The purpose of the article was to analyze data from existing literature sources about the rare pathology of the cecum, which requires surgical treatment. <strong>Material and methods.</strong> Publications have been studied, that present information about the rare pathology of the cecum, the clinical picture and the tactics of surgical treatment of various rare pathologies of the cecum with and without complications. Online databases Google Scholar and PubMed were used as sources for identification of international publications. The keywords used in the search were: "rare pathology of cecum", "cecum mass", "rare cecum inflammatory disease", "cecum bleeding", "cecum acute surgical disease". <strong>Results.</strong> We identified 58 scientific publications that reveal current information about the clinical picture, methods of investigation and treatment of acute appendagitis, acute diverticulitis, necrosis of the cecum wall, cecum volvulus, cecum endometriosis, neuropenic typhlitis, cecum intususception, varicose veins and trauma of the cecum, dermoid cyst of the cecum, Crohn's disease. <strong>Conclusions.</strong> In cases where the clinical picture of acute appendicitis does not correspond to the morphological one and the diverticulum Meckel is missing at the revision of the ileum a thorough examination is necessary to exclude acute appendagitis and deverticulitis of the cecum wall, typhlitis, intussusception and necrosis of the cecum wall, spontaneous cecum perforation. Lower gastrointestinal bleeding of unidentified etiology requires diagnostic colonoscopy to rule out colon tumors and rarer sources of lower gastrointestinal bleeding: varicose veins and endometriosis of cecum. Dermoid cyst, cecum intussusception, typhlitis, Crohn's disease of the ileocecal region can mimic appendicular mass and cecum neoplasms. Pain in the right iliac region in a patient with hematologic cancer associated with neutropenia will be caused by neutropenic typhlitis, and diagnostic laparoscopy will confirm the diagnosis.
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Calle, Catarina, Andreas Pentsch, and Cord Langner. "Mass-forming venous malformation of the cecum." Digestive Endoscopy 28, no. 7 (2016): 755. http://dx.doi.org/10.1111/den.12695.
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Schuetz, Maurice Joseph, and Tarik M. Elsheikh. "Dermoid Cyst (Mature Cystic Teratoma) of the Cecum." Archives of Pathology & Laboratory Medicine 126, no. 1 (2002): 97–99. http://dx.doi.org/10.5858/2002-126-0097-dcmcto.
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Abstract The gastrointestinal tract is an unusual site for teratomas to occur. Only 4 prior cases of teratomas involving the cecum have appeared in the English literature, the latest published in 1977. To the best of our knowledge, this is the first report to describe fine-needle aspiration cytologic findings in addition to histologic features of a mature cystic teratoma involving the gastrointestinal tract. A 30-year-old man presented with right upper quadrant abdominal pain and a palpable abdominal mass. Radiographic studies identified a mass lesion inferior to the liver and in close association with the ascending colon. Fine-needle aspiration biopsy showed scant keratinous material and anucleated squamous cells. Right colectomy revealed a cystic mass in the wall of the cecum that contained keratinous material and was lined by stratified granular squamous epithelium with sebaceous glands. Clinical and pathologic features with review of the literature are presented, and the differential diagnosis for pericolic cystic masses is discussed in detail.
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Jagtap, Sunil Vitthalrao. "Neuroendocrine Tumor of Cecum-Well Differentiated Intermediate Grade: G2 Presented with Aggressive Biologic Behavior: Case Report with Review." Clinical Pathology & Research Journal 6, no. 1 (2022): 1–6. http://dx.doi.org/10.23880/cprj-16000150.
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Neuroendocrine tumors (NETs) are relatively rare neoplasms of the gastrointestinal tract with variable clinical presentations. A 53 year old female presented with a chief complaint of intermittent right-sided abdominal pain, nausea, loose stools of and on of 8 month duration. The computed tomography of abdomen and pelvis, both plain and with contrast revealed the presence of a large well defined homogenously enhancing polypoidal mass lesion noted in the caecum measuring 2.8 X 2.6 X 2.8 cm in size. On colonoscopy revealed the presence of a polypiodal mass in the cecum measuring 3 cm with mucosal ulceration. The biopsy reported as suggestive of neuroendocrine tumor. The wide surgical resection of cecal mass with lymph node dissection was done. On histopatholgy reported as well differentiated neuroendocrine tumor, intermediate grade G2 of cecum with mesenteric lymph node metastasis. On clinical of stage III. The tumor was strong and diffusely positive for expression of synaptophysin and chromogranin A. The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was 3%. Herewith we are presenting rare case of well differentiated neuroendocrine tumor with intermediate grade or grade 2 of cecum with aggressive biologic behavior.
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Böler, Deniz Eren, Cihan Uras, Süha Göksel, and Mehmet Karaarslan. "Actinomycosis of Cecum Associated withEntamoebaInfection Mimicking Perforated Colon Cancer." Case Reports in Gastrointestinal Medicine 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/143218.
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Actinomycosis is a granulomatous disease caused byActinomycesthat mimics other intra-abdominal pathologies especially neoplasms. Correct diagnosis can be rarely established before radical surgery. On the other handEntamoebainfection affects a considerable number of people worldwide. To our knowledge only one case has been reported to be affected by both organisms. We report a man who has been operated for a mass in the cecum mimicking a perforated colon cancer. Abdominal CT revealed a mass with features of an invading neoplasm. After radical surgery, definitive pathology revealed that the mass was due to actinomycosis associated withEntamoebainfection. The postoperative period was uneventful and the patient was on long-course antibiotherapy. It is important to consider actinomycosis especially in patients with intra-abdominal masses with unusual aggressiveness to prevent unnecessary surgery. However, surgery can be unavoidable especially in the presence of complicated disease or high index of suspicion for malignancy.
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Akbal, Erdem, Canan Altunkaya, and Seyfettin Köklü. "A Large Mass in the Cecum of a Young Man." Gastroenterology 139, no. 5 (2010): e1-e2. http://dx.doi.org/10.1053/j.gastro.2009.11.056.
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Karthikeyan, Vilvapathy Senguttuvan, Sarath Chandra Sistla, Duvuru Ram, Sheik Manwar Ali, Sugi Subramaniam Raghavan Velayutham, and Nandhagopal Vijayaraghavan. "Carcinoma Cecum Presenting as Right Gluteal Abscess Through Inferior Lumbar Triangle Pathway—Report of a Rare Case." International Surgery 99, no. 4 (2014): 371–73. http://dx.doi.org/10.9738/intsurg-d-13-00116.1.
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Abstract Gluteal abscess commonly follows intramuscular injections with contaminated needles. Carcinoma cecum is known to present with pericolic abscess due to microperforations and may rupture intraperitoneally. Gluteal abscess secondary to perforated carcinoma cecum with pericolic abscess is extremely uncommon. A 50-year-old woman who was receiving intramuscular iron injections for anemia presented with a 10 × 10-cm abscess in the right gluteal region and a vague mass in the right iliac fossa. After investigations, a diagnosis of perforated carcinoma cecum with pericolic abscess tracking into the right gluteal region was made, and incision and drainage were done. Fine-needle aspiration cytology from the cecal growth revealed adenocarcinoma. Unfortunately, the patient was not willing to undergo definitive treatment. This case is being reported for its rarity and as an uncommon etiology for a common condition.
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Cai, Hongying, Daojie Li, Liye Song, et al. "Metabolomic Characteristics of Liver and Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Lactobacillus plantarum FRT10." Foods 11, no. 16 (2022): 2491. http://dx.doi.org/10.3390/foods11162491.
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Obesity has become a major social problem related to health and quality of life. Our previous work demonstrated that Lactobacillus plantarum FRT10 alleviated obesity in high-fat diet (HFD)-fed mice by alleviating gut dysbiosis. However, the underlying functions of FRT10 in regulating liver and cecum contents metabolism remain unknown. Liver and cecum contents metabonomics combined with pathway analysis based on ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) were performed to evaluate the alterations of metabolic profiles between obese control mice and obese mice in FRT10-treated groups. The orthogonal partial least squares discriminant analysis (OPLS-DA) score plots showed that there were significant differences in cecum contents and liver markers between experimental groups. In total, 26 potential biomarkers were identified in the liver and 15 in cecum contents that could explain the effect of FRT10 addition in HFD-fed mice. In addition, gut–liver axis analysis indicated that there was a strong correlation between cecum contents metabolites and hepatic metabolites. The mechanism of FRT10 against obesity might be related to the alterations in glycerophospholipid metabolism, primary bile acid biosynthesis, amino metabolism, and purine and pyrimidine metabolism. Studies on these metabolites could help us better understand the role of FRT10 in obesity induced by HFD.
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Cheng, Jiangbo, Weimin Wang, Deyin Zhang, et al. "Distribution and Difference of Gastrointestinal Flora in Sheep with Different Body Mass Index." Animals 12, no. 7 (2022): 880. http://dx.doi.org/10.3390/ani12070880.
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Fat deposition is the key factor affecting the efficiency of animal husbandry production. There are many factors affecting fat deposition, in which the gastrointestinal microbiota plays an important role. Therefore, the body mass index (BMI) was introduced into the evaluation of sheep fat deposition, and the different microbiota and functional pathways of the sheep gastrointestinal tract in different BMI groups were analyzed. We selected 5% of individuals with the highest and lowest BMI from a feed test population (357 in whole group). Microorganisms in 10 sites of the gastrointestinal tract in 36 individuals (18 in each group) were evaluated by 16S rRNA V3–V4 region sequencing. There were differences (p < 0.05) in fat deposition traits between different BMI groups. In the 10 parts of the gastrointestinal tract, the diversity and richness of cecal microflora in the high-BMI group were higher than those in low-BMI Hu sheep (p < 0.05). Principal coordinate analysis (PCoA) showed that there was separation of the cecum between groups, and there were differences in the cecal microbial community. Linear discriminant analysis effect size (LEfSe) showed that most biomarkers were in the cecum. On the basis of an indepth study of cecal microorganisms, 26 different bacterial genera were obtained (p < 0.05). Correlation analysis between them and the characteristics of fat deposition in sheep showed that Colidextribacter, Alloprevotella, and Succenivibrio were positively correlated with fat deposition, while Lachnospiraceae_ND3007_Group was negatively correlated (p < 0.05). The above results show that the cecum may be an important part leading to the difference of BMI in sheep, and its microorganisms may affect the level of fat deposition.
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Ramachandran, Biggs Saravanan, Bright Thomas, Shana Baby, and Rosamma Thomas. "Multicentric ameboma of the colon mimicking Crohn℉s disease." Journal of Digestive Endoscopy 06, no. 02 (2015): 076–78. http://dx.doi.org/10.4103/0976-5042.159245.
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AbstractEntamoeba histolytica infection can lead to colitis, colonic perforation abscess, and ameboma formation. Amebic colitis is common in developing countries, with its varied and nonspecific symptoms. Amebomas can occur rarely due to the formation of excess granulation tissue which usually occurs in cecum and ascending colon. A 64-year-old lady presented with abdominal pain and mass in the right side of abdomen. Imaging showed multicentric colonic masses. On colonoscopy multiple stricturizing ulcerated lesions involving cecum, ascending, proximal transverse colon, and splenic flexure were seen, which were suggestive of Crohn′s disease or multicentric neoplasm. Histopathological examination revealed multicentric lesion with focal necrosis and trophozoites of E. histolytica. Diagnosis of ameboma was made and antiamoebic treatment was started. She had full resolution of symptoms. We present this case since it is a case of ameboma, a rare complication of amebic colitis with an extremely rare presentation of multiple ulcerated stricturizing lesions, involving cecum, ascending, transverse colon, and splenic flexure which typically resembled Crohn′s disease.
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Feldhaus, Danielle J., Rachel K. Harris, and Saraswati D. Dayal. "Appendiceal Endometriosis Presenting as Possible Cecal Mass." American Surgeon 86, no. 11 (2020): 1528–30. http://dx.doi.org/10.1177/0003134820933606.
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Background Endometriosis is endometrial tissue located outside of the uterus. Endometriosis is rarely found in the appendix and can present very similar to acute appendicitis and is often indistinguishable on physical exam and imaging. The diagnosis is typically made after an appendectomy on pathology. Case Summary A 45-year-old female presented with right sided abdominal pain and CT revealed a possible cecal or appendiceal lesion. Colonoscopy revealed a submucosal non-obstructing cecal mass. In the operating room, the appendix was completely adherent to the cecum and a laparoscopic ileocecectomy was performed. Pathology revealed endometriosis of the appendix and cecum. Discussion Endometriosis of the appendix is a rare condition reported in less than 1% of females that is diagnosed after an appendectomy is performed for suspected appendicitis or other pathology. This diagnosis is made based on the finding of endometrial glands and stroma in the appendix. This can present as acute appendicitis or appendiceal or peri-appendiceal mass on imaging. When symptomatic, pain can align with the menstrual cycle and hemoperitoneum may be encountered intra-operatively. Treatment can be appendectomy, ileocecectomy, or right hemicolectomy if malignancy is suspected. In the patient we described, an ileocecectomy was performed with the intention of converting to a right hemicolectomy if the frozen section pathology had revealed malignancy. This case illustrates the importance of having a broad differential when diagnosing patients with abdominal pain, especially in women of childbearing age. Conclusion Appendiceal endometriosis should be considered in females of childbearing age with abdominal pain or cecal/appendiceal mass on imaging.
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Poniewierka, Elżbieta, Robert Dudkowiak, and Witold Marczyński. "Impact of sex and body mass index on cecal intubation time. Is it a myth that colonoscopy is easier to perform in obese than lean people?" Journal of Medical Science 85, no. 4 (2016): 298–301. http://dx.doi.org/10.20883/jms.2016.183.
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Introduction. Colonoscopy is the gold standard for prevention and early diagnosis of colorectal cancer. Procedure quality is an important issue. Current quality indicators, such as cecal intubation rate, adenoma detection rate, and withdrawal time, are important, but cecum intubation time influences all of them. Factors that determine cecal intubation time (CIT) include body mass index (BMI), age, sex, history of abdominal surgery, quality of bowel preparation, and visceral adipose tissue. Among those who perform colonoscopy, it is believed that the procedure is easier to perform in obese people. Aim. To determine whether cecal intubation time depends on body mass index and sex of patients undergoing colonoscopy.Material and Methods. An analysis of the technical aspects of colonoscopy, such as the time required to intubate the cecum, with respect to BMI and sex in 100 patients.Results. The average time taken to reach the cecum or ileum was slightly longer in obese people than in people with normal weight. Average CIT was almost one minute longer in men than women. Average CIT in obese men was slightly longer than in normal weight men. There was no difference in average CIT in obese and normal weight women. The differences were not statistically significant.Conclusions. This study demonstrates that the claim that endoscopic examination of the lower gastrointestinal tract is easier to perform in obese people cannot be objectively confirmed.
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Poniewierka, Elżbieta, Robert Dudkowiak, and Witold Marczyński. "Impact of sex and body mass index on cecal intubation time. Is it a myth that colonoscopy is easier to perform in obese than lean people?" Journal of Medical Science 85, no. 4 (2016): 298. http://dx.doi.org/10.20883/183.
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Introduction. Colonoscopy is the gold standard for prevention and early diagnosis of colorectal cancer. Procedure quality is an important issue. Current quality indicators, such as cecal intubation rate, adenoma detection rate, and withdrawal time, are important, but cecum intubation time influences all of them. Factors that determine cecal intubation time (CIT) include body mass index (BMI), age, sex, history of abdominal surgery, quality of bowel preparation, and visceral adipose tissue. Among those who perform colonoscopy, it is believed that the procedure is easier to perform in obese people. Aim. To determine whether cecal intubation time depends on body mass index and sex of patients undergoing colonoscopy.Material and Methods. An analysis of the technical aspects of colonoscopy, such as the time required to intubate the cecum, with respect to BMI and sex in 100 patients.Results. The average time taken to reach the cecum or ileum was slightly longer in obese people than in people with normal weight. Average CIT was almost one minute longer in men than women. Average CIT in obese men was slightly longer than in normal weight men. There was no difference in average CIT in obese and normal weight women. The differences were not statistically significant.Conclusions. This study demonstrates that the claim that endoscopic examination of the lower gastrointestinal tract is easier to perform in obese people cannot be objectively confirmed.
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Huguet, Kevin L., Philip P. Metzger, and David M. Menke. "Colorectal Lymphangioma." American Surgeon 73, no. 4 (2007): 414–16. http://dx.doi.org/10.1177/000313480707300423.
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Lymphangiomas of the colon are historically rare benign tumors. Only 331 cases have been reported in the world medical literature between 1931 and 2004. With widespread use of colonoscopy, however, they are being found more frequently. We report the case of a 74-year-old woman in whom a colonoscopy revealed a 3 x 4-cm submucosal lesion in the cecum that was eventually diagnosed as a lymphangioma. A CT of the abdomen showed a soft-tissue mass in the cecum and a low-density hepatic lesion. An endoscopic ultrasound of the colon showed a 3 x 4-cm hypoechoic lesion with internal septa arising from the submucosal layer of the cecum. This lesion resembled a vascular malformation; therefore a biopsy specimen was not taken. Pathologic findings of a specimen taken after a subsequent right hemicolectomy identified a submucosal lymphangioma. Published reports indicate that colonoscopy cures most lesions smaller than 2.5 cm in diameter. Resection should be reserved for larger lesions or those in patients exhibiting protein-losing enteropathy.
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Temido, M. J., E. Gravito-Soares, M. Gravito-Soares, and P. Figueiredo. "Thinking outside the box in lower gastrointestinal bleeding." Acta Gastro Enterologica Belgica 87, no. 2 (2024): 349–50. http://dx.doi.org/10.51821/87.2.12781.
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A 78-year-old man with prior medical history of chronic kidney disease and atrial fibrillation under apixaban but no recent abdominal trauma presented to the emergency department due to acute abdominal pain. The physical examination was unremarkable except for a distended hypertympanic abdomen with normal bowel sounds and painful upper quadrants of the abdomen with no signs of peritoneal irritation. Laboratory evaluation revealed mild anemia, leukocytosis and elevated C-reactive protein. The patient underwent computed tomography (CT) scan which showed a circumferential bowel wall thickening of the terminal ileum and cecum with fat stranding. A conservative medical treatment was chosen including intravenous antibiotics with partial improvement. Within 11 days of admission, the patient developed melena followed by hematochezia. Upper endoscopy showed no signs of bleeding while colonoscopy (Figure1) revealed an endoluminal dark red-brown mass partially covered by necrotic and yellowish mucosa in the cecum with extensively ulcerated surrounding mucosa. Ileoscopy was not possible since the mass obstructed the ileocecal valve. An angio-CT (Figure 2) was then performed showing a 58x29x37mm hyperdense mass with no signs of active bleeding or thickening of the ileocecal wall.
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Ojo, Peter, Alissa Abenthroth, Paul Fiedler, and George Yavorek. "Migrating Mesh Mimicking Colonic Malignancy." American Surgeon 72, no. 12 (2006): 1210–11. http://dx.doi.org/10.1177/000313480607201211.
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The use of prosthetic mesh is the current acceptable standard for the repair of hernias. Recurrence rate has been greatly reduced since Lichtensen in 1986 first described mesh repair of inguinal hernias. The most common complication arising from inguinal hernia repair even with mesh is recurrence. There are isolated reports of migrated mesh in the three decades of mesh use in hernia repair. We present a case report of a migrated mesh plug presenting with features highly suggestive of an intra-abdominal neoplasm in a 63-year-old man who presented with weight loss, anorexia, fatigue, and a palpable right lower quadrant mass. Work up had revealed a large inflammatory mass involving the cecum and not amenable to percutaneous or colonoscopic biopsy, thus requiring diagnostic laparoscopy. He had a right inguinal hernia repair with mesh 8 years earlier. At diagnostic laparoscopy, an extensive right lower quadrant mass involving the cecum, bladder, and transverse colon and extending to the midline was found, necessitating conversion to open laparotomy and a right hemicolectomy. A mesh plug was found intimately involved with the specimen. Plugs used in inguinal hernia repair rarely migrate. It is rarer still for them to present as a possible colonic mass. This is the first known case report of mesh plug migration presenting as a suspected colonic malignancy.
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Yu, Hung-Chun, Ta-Wei Pu, Jung-Cheng Kang, Chao-Yang Chen, Je-Ming Hu, and Ruei-Yu Su. "Stercoral perforation of the cecum: A case report." World Journal of Gastrointestinal Surgery 16, no. 4 (2024): 1189–94. http://dx.doi.org/10.4240/wjgs.v16.i4.1189.
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BACKGROUND With less than 90 reported cases to date, stercoral perforation of the colon is a rare occurrence. Stercoral ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall, which is caused by the presence of a stercoraceous mass. To underscore this urgent surgical situation concerning clinical presentation, surgical treatment, and results, we present the case of a 66-year-old man with a stercoral perforation. CASE SUMMARY A 66-year-old man with a history of hypertension, hyperlipidemia, and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few hours. Abdominal computed tomography indicated a suspected bezoar (approximately 7.6 cm) in the dilated cecum, accompanied by pericolic fat stranding, mild proximal dilatation of the ileum, pneumoperitoneum, and minimal ascites. Intraoperatively, feculent peritonitis with isolated cecal perforation were observed. Consequently, a right hemicolectomy with peritoneal lavage was performed. A histopathological examination supported the intraoperative findings. CONCLUSION In stercoral perforations, a diagnosis should be diligently pursued, especially in older adults, and prompt surgical intervention should be implemented.
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Fiel, David Carvalho, Iolanda Santos, Joana Eugénio Santos, et al. "Cecum perforation associated with a calcium polystyrene sulfonate bezoar - a rare entity." Brazilian Journal of Nephrology 41, no. 3 (2019): 440–44. http://dx.doi.org/10.1590/2175-8239-jbn-2018-0158.
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Abstract Hyperkalemia is one of the most common electrolyte disorders, responsible for a high number of adverse outcomes, including life-threatening arrhythmias. Potassium binders are largely prescribed drugs used for hyperkalemia treatment but unfortunately, there are many adverse events associated with its use, mostly gastrointestinal. Identification of patients at highest risk for the serious complications associated with the current potassium binders, such as colon necrosis and perforation, could prevent fatal outcomes. The authors present a case of a 56-year-old man with secondary diabetes and chronic renal disease that was treated for hyperkalemia with Calcium Polystyrene Sulfonate (CPS). He later presented with acute abdomen due to cecum perforation and underwent ileocecal resection but ultimately died from septic shock a week later. During surgery, a solid white mass was isolated in the lumen of the colon. The mass was identified as a CPS bezoar, a rare drug-mass formed in the gastrointestinal tract that contributed to the perforation. A previous history of partial gastrectomy and vagothomy was identified as a probable risk factor for the CPS bezoar development. Hopefully, the two new potassium binders patiromer and (ZS-9) Sodium Zirconium Cyclosilicate will help treat such high-risk patients, in the near future.
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George, Virgilio, Luis Velazco, Imtiaz A. Munshi, et al. "Cecum Schwannoma: Uncommon Colonic Mass and New Surgical Approach Using Single Site Laparoscopy." Case Reports in Clinical Medicine 03, no. 03 (2014): 181–85. http://dx.doi.org/10.4236/crcm.2014.33043.
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Kristan, Deborah M. "Effects of intestinal nematodes during lactation: consequences for host morphology, physiology and offspring mass." Journal of Experimental Biology 205, no. 24 (2002): 3955–65. http://dx.doi.org/10.1242/jeb.205.24.3955.
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SUMMARYSublethal parasites are often assumed to have no detrimental effects on their host. However, the sublethal intestinal nematode Heligmosomoides polygyrus affects both the morphology and the physiology of its laboratory mouse (Mus musculus) host and therefore has the potential to affect host life history. The objectives of the present study were to determine (1) whether lactating and non-lactating mice responded similarly to experimental infection with H. polygyrus and (2) whether the changes in morphology and physiology that occurred with parasite infection affected host reproductive performance. Parasitized mice had greater whole body mass as a result of greater lean mass compared with unparasitized mice. Parasitized mice had larger organs (spleen, stomach, cecum and small intestine) and a diminished rate of glucose transport by the small intestine compared with unparasitized mice. Lactating mice had larger organs (liver, kidney, spleen,heart, stomach, large intestine, cecum and small intestine), lean mass and whole body mass, but a similar rate of glucose transport compared with virgin mice. Resting metabolism increased with lactation but not with parasitism. Lactating and non-lactating mice responded similarly to parasite infection for most measured variables. Production of large litters was followed by production of small litters for parasitized but not unparasitized females. After adjusting for parity and litter size, parasitized mothers produced female pups that were 6% smaller at weaning than female pups from unparasitized mothers, but there was no effect of maternal parasite infection on mass at weaning for male pups. Other measures of reproductive output were not affected by parasite infection.
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Babu, Ambrin Farizah, Ville Mikael Koistinen, Soile Turunen, et al. "Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis." Metabolites 12, no. 1 (2022): 49. http://dx.doi.org/10.3390/metabo12010049.
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Sterols, bile acids, and acylcarnitines are key players in human metabolism. Precise annotations of these metabolites with mass spectrometry analytics are challenging because of the presence of several isomers and stereoisomers, variability in ionization, and their relatively low concentrations in biological samples. Herein, we present a sensitive and simple qualitative LC–MS/MS (liquid chromatography with tandem mass spectrometry) method by utilizing a set of pure chemical standards to facilitate the identification and distribution of sterols, bile acids, and acylcarnitines in biological samples including human stool and plasma; mouse ileum, cecum, jejunum content, duodenum content, and liver; and pig bile, proximal colon, cecum, heart, stool, and liver. With this method, we detected 24 sterol, 32 bile acid, and 27 acylcarnitine standards in one analysis that were separated within 13 min by reversed-phase chromatography. Further, we observed different sterol, bile acid, and acylcarnitine profiles for the different biological samples across the different species. The simultaneous detection and annotation of sterols, bile acids, and acylcarnitines from reference standards and biological samples with high precision represents a valuable tool for screening these metabolites in routine scientific research.
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Thombare, Mahesh, Ambrish Shahade, Deepak Phalgune, and Arati Shahade. "A Rare Adenocarcinoma Cecum and Neuroendocrine Carcinoma of Appendix." Indian Journal of Colo-Rectal Surgery 7, no. 1 (2024): 13–15. https://doi.org/10.4103/ijcs.ijcs_6_23.
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ABSTRACT Neuroendocrine tumor (NET) is a malignant tumor with a poor prognosis and can grow at many different sites in the body, but the colon is a very rare site. The diagnosis of NET is often late at the metastasis stage. Colonoscopy identifies most colonic NETs. Whole-body fluorodeoxyglucose positron emission tomography–computed tomography scan can detect a colonic exophytic mass. The histological appearance must be supplemented by an immunohistochemical study. There is no consensus regarding the treatment of colorectal neuroendocrine carcinoma. For localized tumors, surgery associated with adjuvant chemotherapy is a good choice for the management of NETs. Optimal management requires a multidisciplinary and systemic approach. We report a case of a 55-year-old man operated for a NET of the cecum. The tumor cells expressed chromogranin A and synaptophysin. Postoperative chemotherapy was given. The patient was asymptomatic and had no local or distant intra-abdominal secondaries at a 6-month follow-up.
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Rohde, Julia K., Marceline M. Fuh, Ioannis Evangelakos, et al. "A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids." Metabolites 12, no. 2 (2022): 170. http://dx.doi.org/10.3390/metabo12020170.
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Short Chain Fatty Acids (SCFAs) are produced by the gut microbiota and are present in varying concentrations in the intestinal lumen, in feces but also in the circulatory system. By interacting with different cell types in the body, they have a great impact on host metabolism and their exact quantification is indispensable. Here, we present a derivatization-free method for the gas chromatography mass spectrometry (GC-MS) based quantification of SCFAs in plasma, feces, cecum, liver and adipose tissue. SCFAs were extracted using ethanol and concentrated by alkaline vacuum centrifugation. To allow volatility for separation by GC, samples were acidified with succinic acid. Analytes were detected in selected ion monitoring (SIM) mode and quantified using deuterated internal standards and external calibration curves. Method validation rendered excellent linearity (R2 > 0.99 for most analytes), good recovery rates (95–117%), and good reproducibility (RSD: 1–4.5%). Matrix effects were ruled out in plasma, feces, cecum, liver and fat tissues where most abundant SCFAs were detected and accurately quantified. Finally, applicability of the method was assessed using samples derived from conventionally raised versus germ-free mice or mice treated with antibiotics. Altogether, a reliable, fast, derivatization-free GC-MS method for the quantification of SCFAs in different biological matrices was developed allowing for the study of the (patho)physiological role of SCFAs in metabolic health.
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Bansal, R., C. R. Antonescu, R. Thibodeau, and K. Tulla. "A unique case of abdominal pain and anemia." Acta Gastro Enterologica Belgica 85, no. 2 (2022): 416–17. http://dx.doi.org/10.51821/85.2.9942.
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A 38-year-old female presented with intermittent abdominal pain and rectal bleeding and found to have severe anemia. The computerized tomography of abdomen and pelvis with contrast showed a solid mass measuring 5.4 × 3.4 × 3.1 cm in the cecum (Figure 1, left). The colonoscopy revealed a large protruding lesion with ulceration in the right colon (Figure 1,right). Multiple biopsies of the ulcerated area were obtained.
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Baiomi, Ahmed, Hafsa Abbas, Shehriyar Mehershahi, and Myrta Daniel. "Non-Steroidal Anti-Inflammatory Drugs: A Rare Cause of Colonic Mass." Case Reports in Gastroenterology 15, no. 1 (2021): 395–99. http://dx.doi.org/10.1159/000511748.
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NSAIDs (non-steroidal anti-inflammatory drugs) are one of the most used medications worldwide. Every day they are used by more than 30 million Americans. Here, we report a rare and interesting case of a 63-year-old woman with a history of NSAID use who presented to our emergency room with lower abdominal pain. Computed tomography (CT) scan of the abdomen with intravenous contrast revealed focal mucosal thickening in the cecum which was highly suspicious for colonic malignancy. She had a colonoscopy which showed two masses and ulcers in the right colon, pathology was negative for malignancy and showed inflammation consistent with NSAID colopathy.
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Chen, Yuxin, Meredith M. Dinges, Andrew Green, Scott E. Cramer, Cynthia K. Larive, and Christian Lytle. "Absorptive transport of amino acids by the rat colon." American Journal of Physiology-Gastrointestinal and Liver Physiology 318, no. 1 (2020): G189—G202. http://dx.doi.org/10.1152/ajpgi.00277.2019.
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The capacity of the colon to absorb microbially produced amino acids (AAs) and the underlying mechanisms of AA transport are incompletely defined. We measured the profile of 16 fecal AAs along the rat ceco-colonic axis and compared unidirectional absorptive AA fluxes across mucosal tissues isolated from the rat jejunum, cecum, and proximal colon using an Ussing chamber approach, in conjunction with 1H-NMR and ultra-performance liquid chromatography-mass spectrometry chemical analyses. Passage of stool from cecum to midcolon was associated with segment-specific changes in fecal AA composition and a decrease in total AA content. Simultaneous measurement of up to 16 AA fluxes under native luminal conditions, with correction for endogenous AA release, demonstrated absorptive transfer of AAs across the cecum and proximal colon at rates comparable (30–80%) to those across the jejunum, with significant Na+-dependent and H+-stimulated components. Expression profiling of 30 major AA transporter genes by quantitative PCR revealed comparatively high levels of transcripts for 20 AA transporters in the cecum and/or colon, with the levels of 12 exceeding those in the small intestine. Our results suggest a more detailed model of major apical and basolateral AA transporters in rat colonocytes and provide evidence for a previously unappreciated transfer of AAs across the colonic epithelium that could link the prodigious metabolic capacities of the luminal microbiota, the colonocytes, and the body tissues. NEW & NOTEWORTHY This study provides evidence for a previously unappreciated transfer of microbially generated amino acids across the colonic epithelium under physiological conditions that could link the prodigious metabolic capacities of the luminal microbiota, the colonocytes, and the body tissues. The segment-specific expression of at least 20 amino acid transporter genes along the colon provides a detailed mechanistic basis for uniport, heteroexchange, Na+-cotransport, and H+-cotransport components of colonic amino acid absorption.
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Ramesh, Raksha, Shalini Shree Krishnamurthy, Jayashree Natarajan, and Ramakrishnan Ayloor Seshadri. "Synchronous Tumors in the Cecum and Ovary: Differentiating a Primary Colonic Tumor from Metastasis." Indian Journal of Colo-Rectal Surgery 7, no. 3 (2024): 54–57. https://doi.org/10.4103/ijcs.ijcs_14_24.
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ABSTRACT Metastasis to the ovary by colon cancer is a known entity; however, isolated colon metastasis from the ovarian primary is rare. We present a case of a postmenopausal, multiparous woman who had a cecal growth and bilateral adnexal mass, finally diagnosed with primary ovarian cancer without overt peritoneal disease with metastasis to the cecum based on immunohistochemistry. Complete workup and preparedness for intraoperative change of plans are essential while dealing with such situations.
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Mitamura, Mizuho, Satoru Kase, Yuka Suimon, et al. "A Case of Metastatic Iris Tumor from Adenocarcinoma of the Cecum Diagnosed by Combined Tumor Markers in Aqueous Humor and Fine Needle Aspiration Cytology." Case Reports in Oncology 18, no. 1 (2024): 29–34. https://doi.org/10.1159/000542905.
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Introduction: The diagnosis of metastatic iris tumor is made by a fine-needle aspiration biopsy of part of the solid component of the tumor and tumor cells seeded in the anterior chamber; however, sometimes the diagnosis is not made due to insufficient sample volumes. We report a case of metastatic iris tumor in which measurement of tumor marker levels in the aqueous humor together with fine needle aspiration cytology contributed to the diagnosis. Case Report: An 80-year-old Japanese woman was referred to our hospital because of an iris mass. Six months before the initial visit, the patient was diagnosed with adenocarcinoma of the cecum. Slit-lamp microscopy revealed an elevated iris mass. Fine-needle aspiration cytology suggested adenocarcinoma. The carcinoembryonic antigen (CEA) level in the anterior chamber was 5,716.1 ng/mL, and serum CEA level measured on the same day were 678.5 ng/mL. These data indicated CEA levels synchronously elevated in both anterior chamber and serum. Based on aspiration cytology and high CEA levels of anterior chamber, she was diagnosed with metastatic iris tumor derived from adenocarcinoma of the cecum. One month after the initial visit, right eye irradiation was performed for metastatic iris tumor. Conclusions: Measurement of tumor marker levels in the aqueous humor, together with fine needle aspiration cytology of the tumor, contributes to the diagnosis of metastatic iris tumors.
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Principe, Josefina, Anna Mary Jose, Santiago Niño Basto, Isabela Castañeda, and Abdul Rafay Pasha. "Benign Mesenteric Lesion Presenting with Features of a Malignant Mass." International Journal of Applied & Basic Medical Research 13, no. 3 (2023): 186–88. http://dx.doi.org/10.4103/ijabmr.ijabmr_77_23.
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Encapsulated fat necrosis (EFN), most commonly, is an asymptomatic entity and is often found incidentally in images. However, in the abdomen, it may present as an acute abdomen. Mesenteric fat necrosis is part of a larger disease spectrum called collectively mesenteric sclerosis. It results in forming of a mass that can be confused with other pathologies such as liposarcoma, carcinoma of the cecum, and other more benign conditions such as appendagitis of the epiplon. We present the case of an 82-year-old male who presented with an asymptomatic right lower quadrant mass with concerning computed tomography findings with no previous abdominal surgery or trauma history. Diagnosing EFN is crucial as it can mimic bowel cancer and immune-related mesenteric pathology such as sclerosing mesenteritis, the management of which is far more extreme and aggressive than EFN.
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Urban, Jakub, Sławomir Jaworski, Agata Lange, Damian Bień, Arkadiusz Matuszewski, and Monika Michalczuk. "Effects of the Addition of Crude Fibre Concentrate on Performance, Welfare and Selected Caecal Bacteria of Broilers." Animals 13, no. 24 (2023): 3883. http://dx.doi.org/10.3390/ani13243883.
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The study evaluated the effects of crude fibre concentrate supplementation on final body weight, mortality, feed conversion ratio, European Production Efficiency Factor, European Broiler Index, welfare parameters, colony-forming units of selected caecal bacteria (Enterobacteriaceae and lactic acid bacteria) and pH of broiler faeces and litter. The study comprised 990 Ross 308 male chicks divided into three groups, a control and two experimental groups, which were given crude fibre concentrate as a feed supplement. On the thirty-fifth day of rearing, the birds’ welfare scores were evaluated, and 2 g of cecum was collected post-mortem from six chickens in each group. Subsequently, a series of ten-fold dilutions of the material was prepared, followed by cultures and measurement of pH in the faeces and litter. The inclusion of crude fibre concentrate resulted in a beneficial impact on the ultimate body mass (p ≤ 0.001), welfare standard (p ≤ 0.001), and quantity of colony-forming units of lactic acid bacteria (p ≤ 0.05) within the cecum. Furthermore, it had a positive influence on lowering the pH levels of both faeces and litter (p ≤ 0.05).
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Rajack, Fareed, Ali Afsari, and Tammey Naab. "Poorly Differentiated Large-Cell Neuroendocrine Carcinoma of the Cecum: A Rare Malignancy." American Journal of Clinical Pathology 152, Supplement_1 (2019): S65. http://dx.doi.org/10.1093/ajcp/aqz113.068.
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Abstract Poorly differentiated neuroendocrine carcinomas (PDNECs) are rare tumors that can arise anywhere in the gastrointestinal tract. They often present at advanced stage and portend a poor prognosis when compared to adenocarcinomas of the same stage. A 65-year-old female presented with progressively worsening bilateral proximal muscle weakness of 3 months’ duration. It was associated with fatigue, decreased appetite, and unintentional weight loss (8 lbs). She was also found to have hypercalcemia (serum calcium 12.1 mg/dL), anemia (hemoglobin 9.9 g/L), and abnormal liver panel (Alk phos 336, AST 85, GGTP 737). CT abdomen showed abnormal thickening and mass-like enhancement in the cecum measuring 2.9 × 3.7 cm and an enlarged 22-cm liver with numerous rounded masses, the largest measuring 4.6 × 8.2 cm. Colonoscopy revealed a large ulcerated mass distal to the ileocecal valve and extending to the proximal ascending colon. Histology revealed an ulcerated invasive pleomorphic large cell neoplasm with focal squamous differentiation and a tubular adenoma. Initial positive immunostains were AE1/AE3, CK5, and p63. CK7, CK20, S100, and calretinin were negative. Strong, diffuse expression of synaptophysin confirmed neuroendocrine carcinoma; high Ki-67 (80%) confirmed grade 3. CDX2 and TTF1 were positive but are not lineage specific in PDNECs. A liver biopsy had identical histology with diffuse expression of CD56, another confirmatory neuroendocrine marker. Elevated random urine 5-hydroxyindoleacetic acid (5HIAA) supported the diagnosis. Mismatch repair (MMR) protein immunostains did not reveal deficient MMR. Colonic NECs are extremely rare, accounting for 0.6% of patients with colorectal carcinoma; of these, only 0.2% are classified as large cell NECs. A panel of immunostains confirms the diagnosis. They most often arise in the cecum or rectum with early liver metastases and median survival of 9 months. Rare cases have responded to checkpoint inhibitors, which may be a therapeutic option.
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Liao, Xiaoyan, Douglas K. Rex, and Dongwei Zhang. "Mass-forming isolated ischemic necrosis of the cecum mimicking malignancy: Clinicopathologic features of 11 cases." Annals of Diagnostic Pathology 75 (April 2025): 152428. https://doi.org/10.1016/j.anndiagpath.2024.152428.
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Molina, Gabriel A., Darwin R. Ramos, Alberto Yu, et al. "Endometriosis Mimicking a Cecum Mass with Complete Bowel Obstruction: An Infrequent Cause of Acute Abdomen." Case Reports in Surgery 2019 (January 31, 2019): 1–4. http://dx.doi.org/10.1155/2019/7024172.
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Endometriosis is a common entity among fertile women which unfortunately manifests through variable symptomatology. Intestinal involvement in endometriosis is quite common and can simulate several diseases such as Crohn’s disease, appendicitis, tubo-ovarian abscess, or malignant tumors. Intestinal obstruction due to endometriosis is rare, and preoperative diagnosis is difficult because the signs and symptoms are nonspecific and can be easily confused. In the case of patients without a history of endometriosis, diagnosis is further complicated. We present a case of a 41-year-old female patient. She presented to the emergency room with complete bowel obstruction and a mass in the cecum. Surgery was decided, and the patient underwent full recovery. Endometriosis was the final diagnosis for the observed condition.
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Pusiol, Teresa, Doriana Morichetti, Corrado Pedrazzani, and Francesco Ricci. "Abdominal-Pelvic Actinomycosis Mimicking Malignant Neoplasm." Infectious Diseases in Obstetrics and Gynecology 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/747059.
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Abdominal-pelvic actinomycosis is often mistaken for other conditions, presenting a preoperative diagnostic challenge. In a 46-year-old female, computed tomography showed an abdominal-pelvic retroperitoneal mass extending from the lower pole of the right kidney to the lower pelvis. The patient had a 3-year history of intrauterine device. The mass appeared to involve the ascending colon, cecum, distal ileum, right Fallopian tube and ovary, and ureter anteriorly and the psoas muscle posteriorly. The resection of retroperitoneal mass, distal ileum appendicectomy, right hemicolectomy, and right salpingo-oophorectomy was performed. The postoperative period was uneventful. Penicillin therapy was given for six months without any complication. The retroperitoneal mass measured 4.5 × 3.5 × 3 cm, surrounded adjacent organs and histologically showed inflammatory granulomatous tissue, agglomeration of filaments, and sulfur granules ofActinomyces, with positive reaction with periodic acid Schiff. Right tubo-ovarian abscess was present. Abdominalpelvic actinomycosis should always be considered in patients with a pelvic mass especially in ones using intrauterine device.
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Hammond, K. A., M. Lam, K. C. Lloyd, and J. Diamond. "Simultaneous manipulation of intestinal capacities and nutrient loads in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 6 (1996): G969—G979. http://dx.doi.org/10.1152/ajpgi.1996.271.6.g969.
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To study the relationship between capacity and load in the small intestine, we simultaneously varied dietary nutrient load and intestinal capacity in mice. Intestinal transection alone caused an increase in intestinal mass, because of increased serosal mass. Because virgin mouse intestine possesses 180% reserve uptake capacity before resection and the intestine regenerates after resection, resection of up to 50% had no effect on food intake, digestive efficiency, intestinal brush-border glucose uptake rate, or mass of all organs measured except the cecum. Regeneration of intestinal mass and glucose uptake capacity was quantitatively complete, because intestinal mass 10 wk after resection was similar to that in unresected mice. Resected intestinal mass in lactating mice was four times larger than that immediately after resection in virgin mice. Cecal mass increased in 50%-resected lactating mice with high food intakes, suggesting nutrient spillage into the distal gut as a signal for regeneration. Mice failed to survive 70% resection of the intestine, possibly because intestinal reserve uptake capacity was exhausted immediately after surgery, making regeneration impossible.
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Balcytis, Mantas, Vita Klimasauskiene, Kazimieras Brazauskas, and Joseph W. Nunoo-Mensah. "Ileocolic Intussusception Due to Appendiceal Mucocele in Adult Patient." World Journal of Colorectal Surgery 14, no. 1 (2025): 25–27. https://doi.org/10.4103/wjcs.wjcs_34_24.
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Abstract This article presents a case of a 32-year-old male who was admitted to the Department of General Surgery at Republican Vilnius University Hospital. Abdominal and pelvic computed tomography (CT) revealed a well-encapsulated, approximately 45-mm cystic mass near the cecum with signs of intussusception. During open surgery, an intussusception caused by an appendiceal mucocele was identified, and an ileocecal resection was performed. Postoperative pathological examination confirmed ileocecal intussusception and appendiceal mucocele. The patient recovered satisfactorily. This case underscores the rarity of appendiceal mucocele and the associated diagnostic challenges.
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Xie, Wei, Linda K. Green, Rishi A. Patel, and Syeling Lai. "A Case of Unsuspected Peritoneal Mesothelioma Occurring with Colonic Adenocarcinoma Masquerading as Peritoneal Metastases." Case Reports in Pathology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/838506.
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We report a case of synchronous primary colonic adenocarcinoma and malignant mesothelioma. A 61-year-old male presented with a six-month history of fatigue and weight loss. An abdominal computed tomography (CT) scan showed a 5.8 cm partially obstructing mass in the cecum with ascites and peritoneal thickening. A biopsy of the large mass showed an adenocarcinoma. Because the patient was clinically thought to be a T4 colon carcinoma with peritoneal metastatic lesions (M1), prior to initiating chemotherapy, a debulking right hemicolectomy was performed. Resection of the colon and ileum revealed a T3N0 colonic mucinous adenocarcinoma and concurrent diffuse malignant peritoneal mesothelioma. Presenting synchronous colonic and peritoneal mesothelial primary malignancies are exceedingly rare but must be considered to prevent incorrect clinical staging.
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AL-Darkazali, Hind, Vithaya Meevootisom, Duangnate Isarangkul, and Suthep Wiyakrutta. "Gene Expression and Molecular Characterization of a Xylanase from Chicken Cecum Metagenome." International Journal of Microbiology 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/4018398.
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A xylanase genexynAMG1with a 1,116-bp open reading frame, encoding an endo-β-1,4-xylanase, was cloned from a chicken cecum metagenome. The translatedXynAMG1protein consisted of 372 amino acids including a putative signal peptide of 23 amino acids. The calculated molecular mass of the matureXynAMG1was 40,013 Da, with a theoretical pI value of 5.76. The amino acid sequence ofXynAMG1showed 59% identity to endo-β-1,4-xylanase fromPrevotella bryantiiandPrevotella ruminicolaand 58% identity to that fromPrevotella copri.XynAMG1has two conserved motifs, DVVNE and TEXD, containing two active site glutamates and an invariant asparagine, characteristic of GH10 family xylanase. ThexynAMG1gene without signal peptide sequence was cloned and fused with thioredoxin protein (Trx.Tag) in pET-32a plasmid and overexpressed inEscherichia coliTuner™(DE3)pLysS. The purified matureXynAMG1was highly salt-tolerant and stable and displayed higher than 96% of its catalytic activity in the reaction containing 1 to 4 M NaCl. It was only slightly affected by common organic solvents added in aqueous solution to up to 5 M. This chicken cecum metagenome-derived xylanase has potential applications in animal feed additives and industrial enzymatic processes requiring exposure to high concentrations of salt and organic solvents.
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Martinez, Carlos Augusto Real, Júlia Cutovoi, Debora Helena Rossi, et al. "Intramucosal Carcinoma of the Appendix Arising from Traditional Serrated Adenoma." Case Reports in Surgery 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/297450.
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Introduction. Serrated adenomas of the appendix are rare and usually found during appendectomy or autopsies. The preoperative diagnosis of these tumors is uncommon. This report describes a case of a sessile serrated adenoma located in the appendix diagnosed by a screening colonoscopy and successfully treated by laparoscopic removal.Presentation of Case. An 86-year-old woman underwent colonoscopy to investigate the cause of her diarrhea, weight loss, and anemia. During the colonoscopy, an expansive and vegetating mass of 1.5 cm in diameter was identified, protruding through the appendicular ostium with slightly lateral growth to the cecum. The patient was referred for laparoscopic surgical resection due to the location of the lesion, which did not allow its removal by colonoscopy. She underwent wedge removal of the cecum without complications and was discharged on the 4th postoperative day. Histopathological examination showed the presence of a sessile serrated adenoma with an intramucosal adenocarcinoma. The patient is currently well one year after surgery, without endoscopic signs of relapse.Conclusion. Despite serrated adenomas being a possibility rarely described in appendix it should be recognized and properly treated because it is presenting a higher risk of cancer.
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Nakamura, Yuki, Kenji Matsuda, Shozo Yokoyama, et al. "Mass-forming mucosa-associated lymphoid tissue lymphoma of the cecum treated by laparoscopy-assisted bowel resection." International Cancer Conference Journal 8, no. 2 (2019): 66–70. http://dx.doi.org/10.1007/s13691-018-00355-1.
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Singh, Brijesh Kumar, Sudipta Saha, Shilpi Agarwal, and Yashwant Singh Rathore. "Malignant Brenner tumour of the ovary manifesting as distal intestinal obstruction and perforation." BMJ Case Reports 13, no. 6 (2020): e235394. http://dx.doi.org/10.1136/bcr-2020-235394.
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A rare case of malignant Brenner tumour of ovary manifesting with intestinal perforation due to colonic infiltration is elaborated in the present report. Brenner’s tumour accounts for 1%–2% of all ovarian neoplasms and malignant Brenner tumour is even rarer and only about 5% of Brenner tumours are malignant. A 62-year-old woman came to surgical emergency with 1-month history of abdominal pain, vomiting and constipation with a palpable mass in right iliac fossa. Abdominal radiograph was suggestive of colonic obstruction. Contrast-enhanced CT of the abdomen revealed cystic right ovarian mass of 10.2×8.8 cm2 with pneumoperitoneum. Exploratory laparotomy was done, which revealed mass arising from right ovary involving terminal ileum, cecum and ascending colon. Possibility of ovarian malignancy was kept. Patient underwent debulking surgery along with ileostomy and descending colon mucous fistula was created. Histology was compatible with malignant Brenner tumour of the ovary.
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Kim, M., J. Lofthouse, and M. F. Flessner. "Blood flow limitations of solute transport across the visceral peritoneum." Journal of the American Society of Nephrology 8, no. 12 (1997): 1946–50. http://dx.doi.org/10.1681/asn.v8121946.
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In a previous study, no limitations to urea transfer across the parietal peritoneum were demonstrated with decreases in local blood flow of 70%. It was hypothesized that the visceral peritoneum would have similar characteristics. To address this problem at the tissue level, diffusion chambers were affixed to the serosal side of the stomach, cecum, or liver of anesthetized rats (n = 6 each tissue), and solutions containing 14C urea were placed in the chamber. During each experiment, the local chamber blood flow was measured with laser Doppler flowmetry, and, simultaneously, the disappearance of the tracer versus time was determined under three conditions: control, after 60 to 70% blood flow reduction, and postmortem (flow = 0). The results showed no difference in the urea mass transfer coefficient (MTC; mean +/- SEM; cm/min x 10[3]) between control and blood flow reduction for the stomach (4.0 +/- 0.4 versus 3.6 +/- 0.3) or for the cecum (4.6 +/- 0.3 versus 4.0 +/- 0.3). However, the MTC was significantly decreased by local blood flow reduction in the liver (5.4 +/- 0.2 versus 2.6 +/- 0.2). Postmortem data demonstrated significant reductions in the MTC with blood flow equal to zero. It is concluded that a 60 to 70% blood flow reduction from control values does not limit solute transperitoneal transfer in the hollow viscera but causes significant changes in the mass transfer across the liver surface. Because the liver makes up only a small portion of the effective exchange area, overall transperitoneal solute transfer should not be greatly affected by significant decreases in blood flow.
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PROSEKOVA, E. A. "GROWTH AND MORPHOPHYSIOLOGICAL STATE OF THE DIGESTIVE ORGANS OF BROILERS WHEN USING THE FEED ADDITIVE “FARMATAN” (BUTITAN)." Izvestiâ Timirâzevskoj selʹskohozâjstvennoj akademii, no. 6 (2020): 34–48. http://dx.doi.org/10.26897/0021-342x-2020-6-34-48.
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The authors studied the growth characteristics (morphophysiological indicators) of broilers’ digestive organs when using Pharmatan in the diet at doses of 0.025; 0.05 and 0.075%. For the study, three medium-weight broiler chickens were selected – on a daily basis for the first three days, then on a weekly basis. The mass of the stomach, individual intestines, the mass of internal organs, and the coefficient of growth rate were determined according to Brody. To study the relative growth rate, the simple allometry formula y = axb was used. It has been established that the most intensive growth of the digestive organs is observed in the first week of broiler life and consists in the stimulated growth of the intestine, especially the cecum. Later on, the growth of the digestive organs in birds of the control group increases and becomes equal to or higher than in broilers of the experimental group. In general, for 42 days of the experiment, the growth rate of the organs of the gastrointestinal tract is practically the same in the birds of the experimental and control groups. The parameters of the regression equations indicate significant differences in the growth of individual organs of the digestive tube during the individual development of broilers. In the experimental groups of broilers, almost all intestinal organs grow quite intensively (b = 1.325–1.783) during the first week of raising, with relatively low values of determination coefficients (cecum – R2 = 0.355; jejunum – R2 = 0.745). High morphological values of 7-day-old birds treated with Pharmatan form the basis for growing broilers with a higher live weight.
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Chang, Weon Young. "An abdominal actinomycosis was concurred with small intestine perforation by a suspected fishbone." Journal of Medicine and Life Science 7, no. 1 (2010): 168–70. http://dx.doi.org/10.22730/jmls.2010.7.1.168.
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A case of an abdominal actinomycosis, seen in a 41-year-old woman, which concurred small intestine perforation suspected to be the result of a fishbone. The patient complained of able tender mass in the right lower quadrant. Explorative laparotomy was performed under a diagnosis of localized abscess. An inflammatory tumor of small intestine mesentery involving the distal ileum and cecum was treated by ileocecectomy. The resected specimen showed small intestine perforation with abscess, which was histologically diagnosed as actinomycosis but we were not able to find any fishbones. We will discuss possible pathogenesis and the therapeutic modalities.
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Kanneganti, Kalyan, Harish Patel, Masooma Niazi, Kavitha Kumbum, and Bhavna Balar. "Cecal Schwannoma: A Rare Cause of Gastrointestinal Bleeding in a Young Woman with Review of Literature." Gastroenterology Research and Practice 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/142781.
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Schwannomas are rare mesenchymal tumors of the gastrointestinal tract. Occurrence of these tumors is more common in the stomach than in the large intestine. These tumors usually present as polypoidal intraluminal lesions and based on their location can present with rectal bleeding, colonic obstruction, and abdominal pain or defecation disorders. We present a case of a thirty-five-year-old woman who presented with abdominal pain and melena. Patient was diagnosed with a nonobstructing superficially ulcerated mass in the cecum on colonoscopy and required right hemicolectomy. A very rare pathological diagnosis of cecal schwannoma was made postoperatively.
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Tulpule, Sunil, Hiyam Ibrahim, Mohamed Osman, et al. "Muir-Torre Syndrome Presenting as Sebaceous Adenocarcinoma and Invasive MSH6-Positive Colorectal Adenocarcinoma." Case Reports in Oncology 9, no. 1 (2016): 95–99. http://dx.doi.org/10.1159/000443788.
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Muir-Torre syndrome (MTS) is a rare genodermatosis, diagnosed by the presence of sebaceous neoplasms along with an internal malignancy, most commonly colorectal carcinomas. MTS is most commonly caused by microsatellite instabilities of the hMLH1 and hMSH2 mismatch repair genes, and is rarely caused by mutations of the hMSH6 gene. We describe the case of a 56-year-old male who presented with an enlarging mass on his back as well as hematochezia. The back mass was excised, and pathology confirmed microsatellite instability in MSH2 and MSH6. Abdominal CT and colonoscopy confirmed the presence of synchronous masses in the cecum, ascending colon, and the transverse colon. He refused any further workup or treatment, only to return 8 months later complaining of hematochezia and discomfort due to an enlarging mass protruding from the rectum. After consenting to surgical intervention, he agreed to outpatient chemotherapy treatment. The presence of sebaceous neoplasms should raise suspicion for the possibility of an associated internal malignancy.
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Pusapati, Suchitra, Uma Divya Tejaswini Gudipudi, and Krishnam Raju Penumetcha. "Nasal Glial Heterotopia: An Unusual Cause of Lump on the Nose in a Child- A Case Report." Indian Pediatrics Case Reports 5, no. 1 (2025): 43–46. https://doi.org/10.4103/ipcares.ipcares_235_24.
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Abstract Background: Glial heterotopia is a rare, nonneoplastic extracranial displacement of the brain tissue, most commonly seen on the nose. Clinical Description: A 2-year-6-month-old boy presented with a nasal mass gradually increasing since birth, being otherwise asymptomatic. The mass was firm, tense, predominantly skin-colored with some bluish discoloration, with no signs of inflammation, present on the left side of the bridge of the nose. Systemic examination and vitals were normal. Management and Outcome: Contrast-enhanced magnetic resonance imaging scan showed features suggestive of nasal glial heterotopia (NGH), with a thin linear T2-weighted hyperintense stalk extending from the mass up to the foramen cecum. Complete surgical excision, with ligation and cauterization of the fibrous communicating tract, was done close to intracranial entry. Histopathology confirmed the diagnosis of glial heterotopia, with immunohistochemistry showing glial fibrillary acid protein positivity. Conclusion: Pediatricians need to be aware that a slow-growing external nasal mass, present since birth, may be a NGH. Imaging can delineate intracranial connections with confirmation by histopathology after complete excision.
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Incani, Renzo Nino, Eduardo Caleiras, Milena Martín, and Carlos González. "Human infection by Angiostrongylus costaricensis in Venezuela: first report of a confirmed case." Revista do Instituto de Medicina Tropical de São Paulo 49, no. 3 (2007): 197–200. http://dx.doi.org/10.1590/s0036-46652007000300012.
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A proven case of human infection caused by Angiostrongylus costaricensis is reported for the first time in Venezuela. The patient was a 57-year-old female surgically operated because of signs of peritonitis with a palpable mass at the lower right quadrant of the abdomen. WBC count reported 16,600 cells/mm³, with 46% eosinophils. The tumoral aspect of ileocolic area and peritoneal lymph nodes prompted the resection of a large area of the terminal ileum, cecum, part of the ascending colon and a small part of the jejunum, where a small lesion was found. The pathology showed thickened areas of the intestinal wall with areas of hemorrhage and a perforation of the cecum. Histology showed intense eosinophil infiltration of the whole intestinal wall, granulomas with giant cells and eosinophils. Some of the granuloma surrounded round or oval eggs with content characterized by a large empty area, cells or embryo in the center, and sometimes nematode larvae. A cross section of an adult nematode worm was observed inside a branch of mesenteric artery. The intestinal affected area, the characteristics of the lesions, the presence of eggs in the submucosa with nematode larvae inside, and the observation of a nematode inside a mesenteric artery, makes sufficient criteria for the diagnosis of an infection by Angiostrongylus costaricensis.
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Chew, Michael Tsuyoshi, Eric Chak, and Karen Matsukuma. "A Rare Cause of Pulmonary Nodules." Case Reports in Gastroenterology 10, no. 3 (2016): 633–39. http://dx.doi.org/10.1159/000452198.
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Crohn’s disease is a chronic, idiopathic autoimmune disorder that primarily targets the gastrointestinal (GI) system. It is characterized by transmural inflammation of the GI tract that can occur anywhere from the mouth to the anus. Not infrequently, the disease may also have extraintestinal manifestations (EIMs) that can affect almost any organ system. It is estimated that EIMs affect up to 36% of patients with Crohn’s disease, but the incidence and prevalence of pulmonary involvement are variable in the literature and may be as low as 0.4%. There are few case reports documenting pulmonary manifestations, as they are often overlooked, especially if respiratory symptoms are present before the diagnosis of GI manifestations, as in the present case. A 44-year-old otherwise healthy woman presented with nonspecific respiratory complaints, recurrent pneumonias, and multiple computed tomography images showing diffuse, migratory, nodular, and consolidative parenchymal lung disease, with a largely unremarkable infectious and rheumatologic evaluation. Lung biopsy revealed necrotizing and nonnecrotizing granulomas, raising concern for sarcoidosis. Subsequent imaging revealed an incidental mass in the cecum. Biopsy of the cecum lesion revealed acute cryptitis, crypt abscess, and a single poorly formed granuloma, suggesting the possibility of Crohn’s disease. In this report, we present a patient whose pulmonary manifestations ultimately led to the diagnosis of Crohn’s disease.
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Rodriguez-Lopez, M., M. Bailon-Cuadrado, FJ Tejero-Pintor, E. Choolani, G. Fernandez-Perez, and A. Tapia-Herrero. "Ileocecal intussusception extending to left colon due to endometriosis." Annals of The Royal College of Surgeons of England 100, no. 3 (2018): e62-e63. http://dx.doi.org/10.1308/rcsann.2017.0225.
Full textAbstract:
Bowel involvement in endometriosis is uncommon and is most frequently located in the sigmoid colon and the rectum. We present a case in a 37-year-old woman of a cecal endometrioid mass complicated with an ileocolic intussusception which extended beyond the splenic colon flexure. Careful manual extraction allowed a reduction of the intussusceptum, followed by an oncological right hemicolectomy. The patient suffered postoperative ileus, which was spontaneously solved. Intussusception is infrequent in the adult population and usually involves the small bowel. The great majority of ileocolic intussusceptions have a malignant origin (cecal adenocarcinoma). An endometriotic mass located at the cecum as the lead point for ileocolic intussusception is an extremely rare presentation. On reviewing the literature, we found only 13 reports with no other cases extending beyond the splenic flexure, as occurred in our patient.