Relevant bibliographies by topics / CEEP

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  1. Journal articles
  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'CEEP'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "CEEP"

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Sun, Baojun, Taiwen Feng, Mingjing Du, Yuqing Liang, and Tianbao Feng. "Spatially Correlated Network Structure and Influencing Factors of Carbon Emission Efficiency in the Power Industry: Evidence from China." Systems 13, no. 1 (2025): 30. https://doi.org/10.3390/systems13010030.

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As the largest carbon-emitting industry in China, the power industry has huge potential for carbon emission reductions. It is vital to study the spatial correlation of carbon emission efficiency in the power industry (CEEP) from a system perspective to understand the interaction mechanisms of CEEP in different provinces. This study applies the SBM-undesirable model to measure the CEEP in China, and a modified Gravity model and social network analysis (SNA) method are applied to analyze the interaction mechanism of the CEEP from a system perspective. Finally, the influencing factors of the CEEP’s spatial correlation are investigated using the quadratic allocation procedure (QAP) method. The results show that (1) the national CEEP is gradually increasing, while the CEEP gap between provinces is widening; (2) the overall network size shows an increasing trend, but the hierarchical structure is somewhat fixed; (3) the central province of a network has a high degree of consistency with the geographically central province, but the spatial spillover effect of the central node provinces on the peripheral provinces is not sufficient; and (4) differences in geographic proximity, energy intensity, and technical level of power generation significantly affect the formation of spatially correlated networks in the CEEP.
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Chang, Ming, and Min Zhang. "Architecture Design of Datacenter for Cloud English Education Platform." International Journal of Emerging Technologies in Learning (iJET) 14, no. 01 (2019): 24. http://dx.doi.org/10.3991/ijet.v14i01.9464.

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Considering the importance of datacenter to cloud English edu-cation platform (CCEP), this paper designs a novel datacenter for the CEEP which realizes resource pooling on the storage, network, computation and other infrastructures through integration of virtualization technology. Meanwhile, the intelligent, automatic and centralized service orchestration and scheduling man-agement were implemented via the global CEEP system. On this basis, a com-plete datacenter solution was developed for the CEEP. Through performance analysis, it is concluded that the solution can significantly improve the effec-tiveness, resource utilization, service deployment efficiency as well as operation and maintenance management.
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Hsu, Danny, Ibrahim Tohidi-Esfahani, Christina Brown, et al. "Safety and Efficacy of CEEP (Cyclophosphamide, Epirubicin, Etoposide, Prednisolone) with or without Rituximab in Elderly Patients (>70) with Diffuse Large B-Cell Lymphoma (DLBL): A Retrospective Single Center Experience." Blood 118, no. 21 (2011): 4957. http://dx.doi.org/10.1182/blood.v118.21.4957.4957.

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Abstract Abstract 4957 Background Over 40% of patients with the most common lymphoid malignancy worldwide, DLBL, are over the age of 70. Although R-CHOP is inarguably the mainstay of therapy for DLBL patients, a significant number of elderly patients do not tolerate the regimen due to underlying frailty and/or co-morbidities. Most elderly patients with significant co-morbidities have limited treatment options and are not offered anthracycline-containing chemotherapy due to concerns regarding toxicity. Here we describe our single center experience with CEEP, a lower intensity regimen for elderly patients with newly diagnosed or relapsed DLBL whom are deemed inappropriate for CHOP-based chemotherapy. Method All patients >70 years old (median 78.5, range 71 – 85) with histologically proven DLBL treated with CEEP ± Rituximab (R) at Royal Prince Alfred Hospital from 2000 to 2010 were retrospectively reviewed. Modified CEEP, Cyclophosphamide 300mg/m2 Day 1 (D1) and D15, Epirubicin 50mg/m2 D1 and D15, Etoposide 100mg/m2 D1 and D15, and Prednisolone 50mg D1-D5 (reduced dose from original CEEP protocol) was administered every 2 weeks. Rituximab 375mg/m2 (when approved for use in Australia) was administered every 28 days. As per institutional protocol, all patients received Bactrim prophylaxis for Pneumocystis. Baseline characteristics, Charlson Comorbidity Index, Revised International Prognostic Index (RIPI), the number of CEEP cycles, treatment response and toxicity from treatment were identified and reviewed. Results A total of 22 patients were identified, 10 were male. 15 received CEEP as initial therapy, and 7 for relapsed disease. 23% (n=5) had an ECOG score ≥ 2. 55% (n=12) had RIPI ≥ 3. All patients had a Charlson Comorbidity Index ≥ 2, with 23% (n=5) ≥ 5, which was considered sufficient to preclude conventional CHOP-based chemotherapy. Median cardiac ejection fraction was 62% (range 55 – 85%). 73% (n=16) received Rituximab and 50% (n=11) received primary GCSF prophylaxis. The median number of CEEP ± R cycles was 6 (range 2 – 9 cycles). 5% (n=1) required dose reduction and 9% (n=2) required delays in treatment due to haematological toxicity. Median follow-up was 10.0 months (range 1 – 92.7 months). At completion of therapy, complete responses (CR) were demonstrated in 10 patients (45%), with partial responses (PR) seen in 32% (n=7). 18% (n=4) demonstrated progressive disease (PD) despite therapy. Of the 7 patients with relapsed disease prior to CEEP ± R, CR was seen in 2 cases, both of whom had previous exposure to R-CVP (cyclophosphamide, vincristine, prednisolone) chemotherapy. At most recent follow up, 32% (n=7) have remained in CR with a median follow up period of 28.1 months (range 13 – 92.7 months), 36% (n=8) had disease progression, 9% (n=2) demonstrated stable residual disease, while 23% (n=5) have died. Of the 5 deaths, 3 were attributed to progressive DLBL. The other deaths were a result of complications following further salvage chemotherapy. Grade 3 – 4 haematological toxicity was observed in 72% (n=16) of patients. Febrile neutropenia occurred in 41% (n=9). Overall, 50% (n=11) required at least one re-admission to hospital. Non-haematological grade 3 – 4 toxicity was detected in 2 patients, one of whom suffered unstable angina in the setting of anaemia, the other an acute cerebrovascular event in the setting of new atrial flutter post-chemotherapy. Discussion Although limited by a small sample size, our retrospective single center experience demonstrates that CEEP ± R chemotherapy can be administered to elderly patients with significant co-morbidities. Our cohort was all aged >70, with medical co-morbidities leading to the unsuitability of conventional CHOP-based therapy. Whilst an overall response rate of 77% (CR + PR) was observed, on prolonged follow up, 32% of patients remained in CR. Significant haematological toxicity (72%) and infectious complications (41%) were observed, however no deaths were directly attributed to the chemotherapy. Future prospective studies are required to further evaluate the safety and efficacy of R-CEEP in the elderly. Disclosures: No relevant conflicts of interest to declare.
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Yeung, James, Ashlea Campbell, Christian E. Bryant, et al. "Safety and Efficacy of R-CEEP (Rituximab, Cyclophosphamide, Epirubicin, Etoposide, Prednisolone) in Elderly or Unfit Patients with Diffuse Large B-Cell Lymphoma (DLBCL): A Retrospective Single-Centre Experience." Blood 134, Supplement_1 (2019): 2911. http://dx.doi.org/10.1182/blood-2019-131589.

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Background DLBCL is the most common subtype of non-Hodgkin lymphoma in elderly patients (age ≥70). R-CHOP is the standard of care for upfront treatment of fit patients, but may not be tolerated in patients with advanced age and/or comorbidities. There is no established standard of care for this group of patients and dose reduction (R-miniCHOP) or avoidance/replacement of anthracyclines are common strategies, aiming to deliver tolerable immunochemotherapy and provide meaningful outcomes and potential cure. R-CEEP is a dose-reduced regimen that incorporates etoposide and an alternate anthracycline epirubicin. We describe our single-centre experience with R-CEEP for elderly (age ≥70) or unfit patients (CIRS-G >6) with newly-diagnosed or relapsed DLBCL deemed unsuitable for R-CHOP. Method All patients receiving R-CEEP for a histological diagnosis of DLBCL at Royal Prince Alfred Hospital from 2000 to 2019 were retrospectively reviewed. R-CEEP (rituximab 375mg/m2 day 1, cyclophosphamide 300mg/m2 day 1, epirubicin 50mg/m2 day 1, etoposide 100mg/m2 day 1 and prednisolone 50mg daily for days 1-5) was delivered every 14 or 21 days at physician discretion planning for 6 cycles. GCSF and antimicrobial prophylaxis were used at physician discretion. The cardiac ejection fraction was assessed as satisfactory (>50%) prior to commencement. Baseline demographics, R-IPI, co-morbidities as assessed by CIRS-G, treatment response and adverse events (AEs) were recorded. Results Data from 61 patients were reviewed; 54 received R-CEEP for de novo DLBCL and 7 for DLBCL with a background of previously-treated lymphoma (1 DLBCL; 6 low-grade NHL). The median age at diagnosis was 80 (range 34-93), with 79% aged 75 and 28% aged 85. Thirty-three patients (54%) were female; 87% had Ann Arbor stage III/IV and 52% had R-IPI 3-5. Median CIRS-G was 9 (range 2-20) with 74% of patients having CIRS-G >6. GCSF prophylaxis was used in 67%. The median follow-up was 2.7 years (range 0.1-10.0 years). Overall response was 54/61 (89%), with complete response (CR) in 42 (69%), partial response (PR) in 12 (20%) and progressive disease (PD) in 1 (2%). Response was not assessed in 6 patients due to early treatment discontinuation for palliation or AEs (4), cerebral palsy (1) and loss to follow-up (1). In patients receiving R-CEEP as upfront therapy, CR was obtained in 38/54 (70%), PR in 10/54 (19%) and 6 were not assessed as above. In the 7 patients receiving R-CEEP as salvage therapy, 4 obtained CR, 2 PR and 1 had PD. Median PFS and OS for the total cohort were 5.2 and 9.4 years respectively; for de novo DLBCL patients, 7.1 and 9.4 years and for patients receiving salvage therapy, 1.1 and 2.0 years. There was no statistically significant difference in PFS or OS when comparing patients aged <80 and ≥80, or with CIRS-G ≤6 and >6, or CIRS-G ≤9 and >9. Relapsed disease was identified in 19 patients (31%) during follow-up. Of the 75 AEs reported, grade 3/4 AEs accounted for 67%. Infective complications were the most frequent (53%; 40) and febrile neutropenia accounted for 8 AEs. Grade 3/4 haematological toxicity occurred in 19% (14). Despite this, the majority (43/61; 70%) received six cycles of R-CEEP. In the remaining 18 patients, 5 completed 6 cycles with dose-reduction and 13 patients discontinued therapy due to serious AEs (9), treatment intolerance (2) or patient preference (2). Of the 29 deaths recorded during the follow-up period, 18 were due to relapsed/progressive disease; 5 to infection (4 of these in CR, 0.5 to 9 years after the end of treatment, and 1 of urinary sepsis in a patient 3 months after early treatment discontinuation due to toxicity) and 6 to unrelated causes. Discussion We demonstrate that R-CEEP is an effective and deliverable immunochemotherapy in elderly or unfit patients with DLBCL. Furthermore, survival outcomes were not impacted by CIRS-G >9 or age ≥80, illustrating efficacy and tolerability even in patients predicted to have a particularly poor prognosis. Our cohort outcomes are not inferior to those reported in elderly fit patients treated with other dose-reduced regimens including R-miniCHOP (Peyrade et al, Lancet Oncology 2011) and R-miniCEOP (with epirubicin; Merli et al, Leukemia and Lymphoma 2012). This data supports the use of R-CEEP as an alternative immunochemotherapy option for patients with DLBCL who may not be candidates for R-CHOP. Disclosures Iland: Celgene: Other: Speaker honorarium. Ho:La Jolla: Other: investigator meeting travel costs; Novartis: Other: investigator meeting travel costs; Janssen: Other: investigator meeting travel costs; Celgene: Other: investigator meeting travel costs.
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Moreno-Candil, David, Edwin Ricardo Bravo-Verdugo, César Jesús Burgos-Dávila, and Abel Antonio Grijalva-Verdugo. "Educación superior y pandemia: estudio piloto del cuestionario de experiencia educativa durante pandemia." Revista Digital de Investigación en Docencia Universitaria 15, no. 1 (2021): e1347. http://dx.doi.org/10.19083/10.19083/ridu.2021.1347.

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Introducción. La pandemia de la COVID-19 llevó a que la mayoría de los países suspendieran las actividades educativas de forma presencial. En México se optó por continuar el ciclo escolar a distancia. Debido a lo atípico de la situación, no se cuentan con herramientas para evaluar la experiencia del estudiantado ante esta medida. Objetivo. Diseñar y evaluar las propiedades psicométricas del Cuestionario de Experiencia Educativa durante Pandemia (CEEP). Método. El CEEP consta de 89 ítems en escala Likert, se aplicó a una muestra no probabilística de 1,441 estudiantes mexicanos de educación superior. Resultados. Se realizó un Análisis Factorial Exploratorio, se eliminaron ítems con carga factorial inferior a 0.40, ítems restantes se agruparon en 9 factores (50.836% de la varianza total). Los factores y el cuestionario en general arrojaron valores aceptables de consistencia interna (0.670 > a > 0.991). Discusión. Se considera que el CEEP es una herramienta adecuada para evaluar la experiencia estudiantil durante la pandemia. El estudiantado valora positivamente sus aptitudes para la educación a distancia (EaD), así como la calidad y proceder de sus docentes; pese a ello reportan menor satisfacción con la dinámica de la EaD y una experiencia emocional negativa.
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Roberts, Joni R., and Carol A. Drost. "Internet Reviews." College & Research Libraries News 81, no. 7 (2020): 360. http://dx.doi.org/10.5860/crln.81.7.360.

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Effiom, Samuel, Francis Osang, James Diwa Enyia, et al. "Integrating sustainable wind power into Nigeria’s energy system: an analysis of excess electricity, CO2 emissions reduction, and fuel demand implications." Future Sustainability 3, no. 2 (2025): 8–15. https://doi.org/10.55670/fpll.fusus.3.2.2.

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This study explores the integration of sustainable wind power into Nigeria's energy system, focusing on its effects on Excess Electricity Production (CEEP), CO2 emissions reduction, and fuel demand under different scenarios. Using the Energy PLAN modeling tool, the study evaluates Nigeria's energy infrastructure at an electricity demand of 32 TWh per year, incorporating both onshore and offshore wind power capacities. Three regulatory scenarios are considered: Regulation 1 (heat demand only), Regulation 2 (combined heat and electricity demand), and Regulation 3 (heat pump integration). The results indicate that increasing wind power capacity significantly affects CEEP. At maximum wind penetration, CEEP is reduced by 35% under Regulation 2 with heat pump integration, compared to Regulation 1, highlighting the importance of system flexibility. Integrating heat pumps reduces energy waste and optimizes renewable energy use by 40%. The CO2 emissions are reduced by about 28% across all scenarios, with the most significant reductions occurring in systems incorporating heat pumps and wind energy. The study shows that primary energy savings were about 25%, driven by decreased reliance on fossil fuels. Wind energy integration leads to a 30% reduction in natural gas consumption, which remains a significant component of Nigeria’s energy mix. Sensitivity analysis reveals that variability in wind production and enhanced system flexibility can improve overall energy system efficiency by 20%. The study contributes significantly to the understanding of renewable energy integration in Nigeria, offering a comprehensive framework for incorporating intermittent wind energy sources into the national grid.
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Bezerra, Tânia Serra Azul Machado, Cloris Violeta Alves Lopes, and Maria Luzirene Oliveira do Nascimento. "EDUCAÇÃO PROFISSIONAL NA ORDEM DO CAPITAL EM PARNAÍBA/PI: APRENDENDO A SER TRABALHADOR NA SOCIEDADE DO (DES) EMPREGO." Revista Labor 1, no. 8 (2017): 3. http://dx.doi.org/10.29148/labor.v1i8.6694.

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Este estudo é resultado de pesquisa realizada no Grupo de Estudos Marxistas Piauiense, tem como lócus a formação da juventude direcionada à Educação Profissional e a relação desta última com a inserção no mercado de trabalho em Parnaíba-PI. Durante a investigação, propomos uma análise sobre a formação destinada aos jovens da classe trabalhadora e a sua inserção no mundo do trabalho. Nesta perspectiva, compreendemos a juventude enquanto segmento social e histórico ao tempo que indagamos sobre a influência social/econômica/política e ideológica das relações capitalistas na formação desta instância. Nossas reflexões nutriram-se de observações, entrevistas/questionários e leituras de fontes primárias coletadas no Centro de Educação Profissionalizante – CEEP, em Parnaíba/PI. Ressaltamos a importância do debate sobre as metamorfoses no mundo do trabalho contemporâneo e a problemática da empregabilidade para a compreensão da relação entre mercado de trabalho e educação no CEEP. Refletimos ainda sobre a dualidade existente entre ensino técnico e educação integral, como causa da divisão entre trabalho manual e trabalho intelectual.
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Espírito Santo, Eniel, Roney Gusmão, and Jeferson Santana dos Santos. "AUTOAVALIAÇÃO DAS COMPETÊNCIAS DIGITAIS DOS PROFESSORES: UM ESTUDO COM DOCENTES DA EDUCAÇÃO PROFISSIONAL EM SANTO AMARO, BAHIA." Interfaces Científicas - Educação 12, no. 2 (2024): 121–36. http://dx.doi.org/10.17564/2316-3828.2024v12n2p121-136.

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Interessa-nos analisar o nível das competências digitais dos professores do Centro Estadual de Educação Profissional em Turismo do Leste Baiano (CEEP-TLB), visando identificar lacunas que dificultam sua práxis pedagógica online. O estudo fundamenta-se no marco teórico das competências digitais dos professores (DigCompEdu), que pressupõe as tecnologias digitais ressignificadas a partir das necessidades contextuais. Configura-se como uma pesquisa exploratória e descritiva, com abordagem quantitativa e dados coletados com 20 professores do CEEP-TLB, por meio da escala de autoavaliação DigCompEdu. Os resultados apontam que os professores estão no nível mediano, B1 (integradores), são capazes de aplicar e refletir sobre sua práxis com as tecnologias. Entretanto, possuem lacunas em usar estratégias de pesquisa online; no desenvolvimento de metodologias ativas e no fornecimento de orientações aos estudantes para um comportamento seguro online. Concluímos que a autoavaliação possibilitou identificar os pontos de melhoria, revelando as necessidades formativas dos professores no desenvolvimento das competências digitais.
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Conceição, Beatriz Souza da, Luiz Guilherme de Souza Carqueija, Milena da Conceição Rangel, Zeisla Neres Pinto, and Flavia da Conceição Pinto. "LÍQUIDO EXTRAÍDO DA MANDIOCA: MANIPUEIRA, PRECIOSIDADE NAS COMUNIDADES QUILOMBOLAS NO MUNICÍPIO DE MARAGOGIPE, BAHIA." Cadernos Macambira 8, no. 2 (2023): 32–33. http://dx.doi.org/10.59033/cm.v8i2.888.

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O resumo apresenta um relato de experiência de discentes do curso técnico em agropecuária do Centro Estadual de Educação Profissional Vale do Paraguaçu Comunidade Quilombola (CEEP VP). O projeto iniciou em fevereiro de 2022, com a pretensão de finalizar em maio de 2022. Objetivou-se, neste trabalho, verificar o uso da manipueira, subproduto obtido a partir da mandioca, durante a produção de farinha nas Comunidades Quilombolas, localizadas no município de Maragogipe Bahia. O referido estudo está sendo desenvolvido nas Comunidades Quilombolas Guaruçú, Guaí, Tabatinga e Departamento de Tecnologia Social (Casa de Farinha) do CEEP VP. Iniciou o estudo com revisão bibliográfica, visitas e registros fotográficos. Estas comunidades são formadas principalmente por pequenos produtores de mandioca, que têm na farinha um dos principais meios de renda. O projeto foi dividido em cinco etapas, que consiste em revisão bibliográfica, visitas as comunidades, registro fotográfico, criação e distribuição de uma cartilha, realização de uma roda de conversa com os agricultores, apresentando as principais alternativas para o destino ecológico da manipueira, entre elas a fabricação de vinagre, sabão e adubo orgânico.
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Dissertations / Theses on the topic "CEEP"

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Xavier, Carlos Alberto Silva. "Participação política dos jovens estudantes do ensino médio e profissionalizante do CEEP Profª Maria do Rosário Castaldi." Universidade Estadual de Londrina. Centro de Estudos Sociais Aplicados. Programa de Pós-Graduação em Serviço Social e Política Social, 2015. http://www.bibliotecadigital.uel.br/document/?code=vtls000202702.

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Esta dissertação apresenta uma reflexão sobre a participação política dos jovens estudantes do ensino médio e profissionalizante da rede pública estadual, considerando que, dentre as finalidades previstas nas diretrizes curriculares do Conselho Nacional de Educação, para esta etapa do ensino básico, constam a formação do aluno como pessoa humana, o desenvolvimento da autonomia intelectual e pensamento crítico, além da preparação para o trabalho e cidadania. Objetivamos investigar a participação política desses jovens e, em que medida esta participação pode contribuir para solução dos problemas vivenciados no ambiente escolar, bem como, oferecer melhorias na qualidade do processo educacional. Este estudo está relacionado à busca de elementos e estratégias que contribuam para o maior interesse dos jovens com o processo de ensino e aprendizagem, bem como a sua formação política para lidar com os problemas do ambiente escolar, sejam estes de caráter pedagógico ou de gestão. Estabelecemos como campo de pesquisa o CEEP Prof.ª Maria do Rosário Castaldi, situado na cidade de Londrina e, consequentemente como sujeitos, os alunos (as) matriculados(as) nos últimos períodos dos cursos do ensino médio normal, eletrotécnica, mecatrônica e administração. A opção metodológica tem dimensão qualitativa, que possibilita a percepção da complexidade das interações sociais que vive o jovem estudante, suas formas de intervenção social e concepções acerca da dinâmica de funcionamento do ambiente escolar. Buscamos o aporte teórico da Sociologia, Serviço Social e Pedagogia, para identificar a pertinência das categorias de análise da pesquisa. Durante os meses de abril a setembro de 2014, e julho de 2015, foram feitas observações em sala de aula, das disciplinas de sociologia, bem como de reuniões e eventos promovidos pela escola, além da realização de uma oficina temática e aplicação de dois questionários aos estudantes, professores e coordenadores. De posse da análise dos dados, concluímos que os jovens estudantes necessitam de estímulos e atitudes motivacionais por parte dos educadores, no sentido de lhes oportunizar a participação política, organizada, crítica e coletiva para que possam contribuir com a busca de soluções para os problemas do ambiente escolar e do processo de construção do conhecimento.<br>This paper presents a reflection on the political participation of young students from public schools of secondary-school and professional education, considering that among the purposes in the curriculum guidelines of the National Council of Education, for this stage of basic education, included student education as a human person, the development of intellectual autonomy and critical thinking, as well as preparation for work and citizenship. We aimed to investigate the political participation of these young people, and to what extent this participation can contribute to solving the problems experienced in the school environment as well, offering improvements in the quality of the educational process. This study is related with search elements and strategies that contribute to the greater interest of young people with the process of teaching and learning, as well as their political training to deal with the school environment problems, be they pedagogical or management. Established as a research field CEEP Professor Maria do Rosario Castaldi, located in Londrina and therefore as subjects, students enrolled in the last periods of the normal high school courses, electrical engineering, mechatronics and administration. The methodological option has qualitative dimension, which enables the perception of the complexity of social interactions experienced by the young student, their forms of social intervention and conceptions of the working dynamics of the school environment. We seek the theoretical contribution of Sociology, Social Work and Education, to identify the relevance of the analysis categories of the survey. During the months of April to September 2014 and July 2015, observations were made in the classroom during sociology classes, as well as meetings and events organized by the school, in addition to holding a thematic workshop and application of two questionnaires students, teachers and coordinators. Armed with the data analysis, we concluded that young students need stimulus and motivational attitudes of educators towards them create opportunities for political participation, organized, critical and collective so that they can contribute to finding solutions to the problems of education and knowledge building process environment.
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Cotrim, Irene Carvalho de Brito. "Cultura organizacional e gestão da mudança: um estudo de caso CEEP – Centro Estadual de Educação Profissional de Guanambi." Escola de Administração da Universidade Federal da Bahia, 2015. http://repositorio.ufba.br/ri/handle/ri/18142.

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Submitted by Tatiana Lima (tatianasl@ufba.br) on 2015-10-19T21:16:52Z No. of bitstreams: 1 IRENE CARVALHO DE BRITO COTRIM.pdf: 4676892 bytes, checksum: bbc999a5551d4af5c21c50446710eef6 (MD5)<br>Approved for entry into archive by Tatiana Lima (tatianasl@ufba.br) on 2015-10-19T21:30:23Z (GMT) No. of bitstreams: 1 IRENE CARVALHO DE BRITO COTRIM.pdf: 4676892 bytes, checksum: bbc999a5551d4af5c21c50446710eef6 (MD5)<br>Made available in DSpace on 2015-10-19T21:30:23Z (GMT). No. of bitstreams: 1 IRENE CARVALHO DE BRITO COTRIM.pdf: 4676892 bytes, checksum: bbc999a5551d4af5c21c50446710eef6 (MD5)<br>This paper aims at analyzing how the organizational culture elements of the State Center for Health and Management Professional Education – CEEP influenced and influence the process of change experienced by the institution. Thereby it is discussed the important role played by the organizational culture in public education institutions, as they also present deep rooted cultural elements of politics and national culture. This study is specially based in Prates and Barros (1996), using the model of investigation and analysis of cultural features found in Brazilian companies and that influence their management, the “Brazilian Style of Managing”. For this purpose, desk research, participant observation and semi-structured interviews with former and present teachers, managers, articulators, and educational coordinator were carried out. Features of national culture were identified in the first managements of CEJDC (Educational Center João Durval Carneiro) as abuse of power, mobilization and affectivity. In its process of change to CEEP (State Center for Health and Management Professional Education – Guanambi-BA) those features were modified, others were produced that influenced the current management and the operation of the whole school community, either complicating or facilitating the change. The research can be used by other Centers of Productive Backland that face problems which generate similar situations, as one more element of analysis, comparison and discussion for the production of new knowledge and strategies of change.<br>O presente estudo analisa como elementos da cultura organizacional do Centro Estadual de Educação Profissional em Saúde e Gestão – CEEP influenciaram e influenciam no processo da mudança pelo qual passa a instituição. Com isso, discute-se a relevância do papel desempenhado pela cultura organizacional nas instituições públicas de ensino, por estas apresentarem, também, elementos culturais mais arraigados da política e da cultura nacional. Este estudo se fundamenta, especialmente, em Prates e Barros (1996), utilizando o modelo de investigação e análise dos traços culturais encontrados nas organizações brasileiras e que influenciam nas suas gestões, o “Estilo Brasileiro de Administrar”. Para este fim foram realizadas pesquisa documental, observações participantes e entrevistas semi-estruturadas com professores, gestores, articuladores dos eixos tecnológicos e coordenação pedagógica, antigos e atuais. Foram identificados traços da cultura nacional nas primeiras gestões do CEJDC (Centro Educacional João Durval Carneiro), como abuso de poder, mobilização e afetividade. No seu processo de mudança para CEEP (Centro Estadual de Educação Profissional em Saúde e Gestão – Guanambi-BA) estes traços foram modificados, produzindo e criando outros que influenciam a gestão atual e o proceder de toda a comunidade escolar, ora dificultando, ora facilitando a mudança. A pesquisa poderá ser utilizada por outros Centros do Sertão Produtivo, que enfrentam problemas que geram situações análogas, como mais um elemento de análise, comparação e discussão, para produção de novos conhecimentos e estratégias de mudança.<br>This paper aims at analyzing how the organizational culture elements of the State Center for Health and Management Professional Education – CEEP influenced and influence the process of change experienced by the institution. Thereby it is discussed the important role played by the organizational culture in public education institutions, as they also present deep rooted cultural elements of politics and national culture. This study is specially based in Prates and Barros (1996), using the model of investigation and analysis of cultural features found in Brazilian companies and that influence their management, the “Brazilian Style of Managing”. For this purpose, desk research, participant observation and semi-structured interviews with former and present teachers, managers, articulators, and educational coordinator were carried out. Features of national culture were identified in the first managements of CEJDC (Educational Center João Durval Carneiro) as abuse of power, mobilization and affectivity. In its process of change to CEEP (State Center for Health and Management Professional Education – Guanambi-BA) those features were modified, others were produced that influenced the current management and the operation of the whole school community, either complicating or facilitating the change. The research can be used by other Centers of Productive Backland that face problems which generate similar situations, as one more element of analysis, comparison and discussion for the production of new knowledge and strategies of change.
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Albers, Kerstin. "Rechtsanspruch auf Verringerung der Arbeitszeit in Deutschland und Italien eine rechtsvergleichende Studie unter Berücksichtigung der Richtlinie 97/81/EG des Rates zu der von UNICE, CEEP und EGB geschlossenen Rahmenvereinbarung über Teilzeitarbeit vom 06. Juni 1997." Baden-Baden Nomos, 2009. http://d-nb.info/999785753/04.

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Bancroft, James M. "Chromosome congression by CENP-E and CENP-Q dependent pathways." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/62106/.

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The timely and efficient movement of chromosomes to the spindle equator during mitosis is a prerequisite for accurate chromosome segregation. Recent work has shown that the majority of chromosomes are able to congress and biorientate almost instantaneously after nuclear envelope breakdown due to their position relative to the forming spindle. However, other mechanisms are required to facilitate the congression of chromosomes, which do not congress in this initial wave. Congression of these remaining chromosomes is mediated by multiple mechanisms including: (1) Kinetochore sliding along the microtubule lattice using the Kinesin-7 CENP-E, and (2) kinetochores biorientating near the pole and congressing through microtubule depolymerisation-coupled movement. Here, we show that the constitutive centromere associated network (CCAN) subunit CENP-Q is required for both mechanisms. CENP-Q is required to recruit CENP-E to kinetochores thus explaining the absence of lateral sliding in CENP-Q depleted cells. Because depletion or inhibition of the CENP-E motor does not affect depolymerisation-coupled pulling, we identify a CENP-E recruitment-independent role for CENP-Q in chromosome congression. Following congression we find that biorientated kinetochore movements require both CENP-Q and CENP-E dependent mechanisms. This suggests that as biorientated kinetochores congress they switch into a mode that requires CENP-E motor activity.
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Abboud, Karim. "Wideband CELP speech coding." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56805.

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The purpose of this thesis is to study the coding of wideband speech and to improve on previous Code-Excited Linear Prediction (CELP) coders in terms of speech quality and bit rate. To accomplish this task, improved coding techniques are introduced and the operating bit rate is reduced while maintaining and even enhancing the speech quality.<br>the first approach considers the quantization of Liner Predictive Coding (LPC) parameters and uses a three way split vector quantization. Both scalar and vector quantization are initially studied; results show that, with adequate codebook training, the second method generates better results while using a fewer number of bits. Nevertheless, the use of vector quantizers remain highly complex in terms of memory and number of computations. A new quantization scheme, split vector quantization (split VQ), is investigated to overcome this complexity problem. Using a new weighted distance measure as a selection criterion for split VQ, the average spectral distortion is significantly reduced to match the results obtained with scalar quantizers.<br>The second approach introduces a new pitch predictor with an increased temporal resolution for periodicity. This new technique has the advantage of maintaining the same quality obtained with conventional multiple coefficient predictors at a reduced bit rate. Furthermore, the conventional CELP noise weighting filter is modified to allow more freedom and better accuracy in the modeling of both tilt and formant structures. Throughout this process, different noise weighting schemes are evaluated and the results show that the new filter greatly contributes in solving the problem of high frequency distortion.<br>The final wideband CELP coder is operational at 11.7 kbits/s and generates a high perceptual quality of the reconstructed speech using the fractional pitch predictor and the new perceptual noise weighting filter.
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AGUIAR, SERGIO RICARDO MONTENEGRO FERNANDES. "LOW DELAY CELP STRUCTURES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 1992. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=8821@1.

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ICHTUS ELETRÔNICA SA<br>Neste trabalho são examinadas estruturas CELP com baixo retardo (da ordem de 2 ms) para codificação digital de voz a taxas de bits de 8 k, 9,6 k e 16 kbit/s. São avaliados sete algoritmos de predição adaptativa a partir do sinal sintetizado. Esses algoritmos são usados para adaptação do filtro de predição com retardo curto e do filtro de ponderação de codificadores CELP com baixo retardo. Dos algoritmos analisados, um emprega adaptação em bloco e os outros são recursivos utilizando estruturas transversais e em treliça. As comparações são baseadas em termos das medidas objetivas de razão sinal ruído (RSR), razão sinal ruído segmentar (RSRSEG) e razão sinal ruído ponderada em freqüência (RSRW) e em termos de medidas subjetivas obtidas através de testes de escuta informais.<br>Low delay (about 2 ms) CELP structures are studied for digital coding of speech at 8, 9,6 and 16 kbit/s. Seven backward adaptative prediction algorithms are investigated. These algorithms are used for adapting the short-term prediction filter and the weighting filter in low delay CELP coders. One algorithm uses block adaptation and the others are recursive with transversal and lattice structures. Comparisons are based on the objective measures of signal to noise ratio, segmental signal to noise ratio and a frequency weighted signal to noise and on subjective results obtained from informal listening tests.
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Gurden, Mark David James. "The Regulation of Cenp-F degradation." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518896.

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Ghenania, Mohamed. "Techniques de conversion de format entre codeurs CELP normalisés : Speech coding format conversion between standardized CELP coders." Rennes 1, 2005. http://www.theses.fr/2005REN11038.

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Cette thèse porte sur la conversion de format en codage de la parole (CELP), ou transcodage. La solution classique de conversion de format, appelée tandem, nécessite la mise en cascade d'une opération de décodage et d'une opération de re-codage. Cette approche par défaut utilisée aujourd'hui dans les réseaux de communications présente des inconvénients en terme de complexité, de délai et de qualité. Pour pallier ces problèmes, l'idée de transcodages dits « intelligents » a été étudiée. En s'appuyant sur les caractéristiques du modèle commun utilisé par les codeurs CELP, la conversion de format peut être rendue plus efficace. Les codeurs CELP extraient du signal puis quantifient et transmettent quatre jeux de paramètres: les coefficients LPC, l'excitation adaptative, l'excitation fixe et les gains associés. Dans cette thèse, on se propose de développer pour ces paramètres des techniques efficaces de conversion entre les principaux codeurs CELP utilisés aujourd'hui
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須摩, 美智子. "分裂酵母CENP-CはCENP-Aの局在を制限する". Kyoto University, 2019. http://hdl.handle.net/2433/242560.

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Jammy, Thierry. "L'accord automobile CEE-Japon." Paris 1, 1994. http://www.theses.fr/1994PA010025.

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Dans son cycle de vie, le produit automobile sur les trois grands marches (États-Unis, Europe de l'ouest, Japon ) a atteint la phase de maturité, ce qui conjugue à l'offensive commerciale et industrielle des constructeurs automobiles japonais sur ces mêmes marchés, a provoqué un fort renforcement de l'intensité concurrentielle. Opérant dans un oligopole en guerre, les acteurs ont alors favorise l'émergence d'un néo-protectionnisme, dont une des formes est représentée par des accords de restriction volontaire des exportations, tels que l'accord automobile CEE-Japon. Les négociations menées durant plus d'une année entre me MITI et la CEE, ont abouti le 31 juillet 1991 à la signature de cet accord, dont le principal objectif est que la pénétration des automobiles japonaises dans la CEE, soit réalisée progressivement d'ici à la fin de la décennie. Cet accord qui ne repose sur aucun support juridique officiel, à l'exception d'une vague notification au GATT, s'est en fait révélé davantage un accord de compromis entre les différents états membres de la CEE, plutôt qu'un accord entre la CEE et le Japon. Finalement, en raison de la pauvreté du champ de la réflexion et plus encore de l'absence de définition du produit de référence dans sa dimension transplant, les constructeurs automobiles japonais pourront aisément contourner l'accord ou encore être prêts pour une offensive massive à la fin de la période de transition tout en continuant à protéger leur marché national. Globalement, l'accord impliquera une aggravation de la crise de surcapacité et un renforcement de la guerre des prix, avec pour corollaire la remise en cause de la survie de certains des constructeurs automobiles européens en tant qu'entités juridiques distinctes. De plus, il implique des partages de marches contraires à l'esprit du GATT et au traité de Maastricht<br>In its life cycle, the automobile product on the three major markets (USA, West Europe, Japan) has reached its maturity phase. This fact, linked with both a commercial and an industrial offensive of Japanese car makers on the same markets, has generated a strong thigthening of competitive intensity. Competing in a war state oligopoly, players then favored the emergence of neo-protectionism sampled by volontary restrictions on exports, as witnessed by the EEC-Japan automobile agreement. Negociations between the miti and EEC lasted for more than one year and ended on july 31, 1991 with the signature of the agreement whose main objective is to organize a progressive entry of Japanese cars into the EEC until the end of the century. This agreement, built on no official legal material, except for a memorandum to the GATT, proved itself rather as a compromise between EEC members than between Europe and Japan. Finally, due to a poor thinking process and rather more due to a lack of definition of the reference product in its transplant acceptation, the Japanese car makers will be in a position to easily go around the agreement and to be ready for a massive offensive by the end of the transition period, while still preserving their national market. As a whole, the agreement will imply a worsening of the overcapacity crisis and a strengthening of the price war, wich raises the question of the survival of some European car makers as independant legal entities. Furthermore, the agreement implies a sharing of the markets in opposition with the GATT spirit and the maastricht treaty
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Books on the topic "CEEP"

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Centre européen de l'entreprise publique. Deutsche Sektion. Die Rolle der öffentlichen Wirtschaft bei der Erneuerung der Wirtschaftkraft Europas: Dokumentation : X. Kongress der CEEP : Lissabon 1984. Ges. für Öffentl. Wirtschaft u. Gemeinwirtschaft, 1985.

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européennes, Commission des Communautés. Traités instituant les Communautés européennes (CECA, CEE, CEEA): Acte unique européen, textes relatifs aux Communautés. Office des publications officielles des Communautés européennes, 1987.

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Dam & Partners Architecten., ed. Cees Dam. Nieuw Amsterdam, 2007.

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Ferreira, Eduardo de Sousa. Portugal--países africanos--CEE, cooperação e integração: Workshop realizado no Centro de Estudos da Dependência--CEDEP. Gradiva/CEDEP, 1985.

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Lootsma, Bart. Cees Dam, architect. Uitgeverij 010, 1989.

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Juffer, Anna. Cees Nooteboom, Rituelen. Walva-Boek, 1989.

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Jamra, Tsukumo Nina Maria, and Companhia Energética de São Paulo., eds. Arquitetura na CESP. CESP, 1994.

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Jamra, Tsukumo Nina Maria, and Companhia Energética de São Paulo., eds. Architecture at CESP. CESP, 1994.

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Nooteboom, Cees. Zurbarán & Cees Nooteboom. Atlas, 1992.

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Seen, Maamadu. Ceer no kiin. PAPA, 1999.

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Book chapters on the topic "CEEP"

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Cerfeda, Walter. "La CES e la politica europea della CGIL." In Diritti, Europa, Federalismo. Firenze University Press, 2023. http://dx.doi.org/10.36253/979-12-215-0049-3.14.

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The essay focuses on the role of trade union in the European integration, the strengthening of the European Trade Union Confederation, the European social dialogue and the relationship with the the President of the European Commission Delors. In particular, the essay illustrates Trentin's commitment to the recognition of a more straightforward negotiating role of the social partners. This was reached in 1991 when Ces, Unice and Ceep claimed from Delors' Commission the possibility of mandatory consultation in order to be able to negotiate directly afterwards, on all social issues on which the Commission intended to legislate. A diplomacy labor effort that later led to the establishment in 1992 of the European Social Dialogue Committee.
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Tiraboschi, Michele. "«La sfuggente temporaneità»: un dialogo con Riccardo Del Punta sul lavoro a termine." In Studi e saggi. Firenze University Press, 2024. https://doi.org/10.36253/979-12-215-0507-8.67.

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This paper explores the reform of fixed-term contracts and temporary agency work following the enactment of Article 24 of Decree-Law No. 48/2023, later converted into Law No. 85/2023. It provides an opportunity to revisit Riccardo Del Punta’s work on the evolution of these employment schemes in light of Council Directive No. 1999/70/EC, which transposed the framework agreement of 18 March 1999 between the European cross-industry organisations (ETUC, UNICE, and CEEP) representing employers and workers. The discussion begins with Professor Del Punta’s paper "The Elusive Temporariness: Consolidated Notes on Fixed-term Work and Temporary Agency Work," published in Industrial Relations Law, Vol. 4/XII, 2000. The author of this paper is particularly fond of Riccardo’s article, as it was expressly dedicated to Professor Marco Biagi, the cultural mastermind of Legislative Decree No. 368 of 6 September 2001, which integrated Council Directive No. 1999/70/EC into our legal system (Biagi, 2002a); Riccardo’s paper were precisely directed to this legislation.
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Wiedenstried, Holger E. "Nooteboom, Cees." In Kindlers Literatur Lexikon (KLL). J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_12799-1.

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Auer, Stefan, and Thomas Stiegler. "CEEC–China." In China's Relations with Central and Eastern Europe. Routledge, 2017. http://dx.doi.org/10.4324/9781315226644-6.

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Wiedenstried, Holger E. "Cees Nooteboom." In Kindler Kompakt Niederländische und Flämische Literatur. J.B. Metzler, 2016. http://dx.doi.org/10.1007/978-3-476-05519-4_48.

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Klien, Michael, and Maria Salvetti. "CEE." In Facing the Challenges of Water Governance. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-98515-2_10.

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Zondergeld, Rein A. "Nooteboom, Cees: Rituelen." In Kindlers Literatur Lexikon (KLL). J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_12800-1.

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Wiedenstried, Holger E. "Nooteboom, Cees: Allerzielen." In Kindlers Literatur Lexikon (KLL). J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_12802-1.

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Goodrich, Andrew. "Vince Cee." In Peer Mentoring in Music Education. Routledge, 2022. http://dx.doi.org/10.4324/9781003243618-11.

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Anisin, Alexei. "Contextualizing CEE." In Mass Shootings in Central and Eastern Europe. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-89373-6_3.

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Conference papers on the topic "CEEP"

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Hanus, Václav, Beatrix Fehér, Zsuzsanna Pápa, et al. "Serial Carrier-Envelope Phase Detection and Modulation for PHz Optoelectronics." In CLEO: Fundamental Science. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/cleo_fs.2024.fw3b.7.

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This study demonstrates a serialized carrier-envelope phase (CEP) measurement using a 250-nm 2D heterostructure, revealing measurable CEP shifts suitable for PHz optoelectronics, advancing the potential for CEP-based communication networks.
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Chan, Henry, Sorel Reisman, and Simanta Mitra. "Message from the CEEP Workshop Organizers." In 2016 IEEE 40th Annual Computer Software and Applications Conference (COMPSAC). IEEE, 2016. http://dx.doi.org/10.1109/compsac.2016.273.

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Sena, Sidney Barbosa de. "OFICINA SUSTENTÁVEL: PROMOVENDO PRÁTICAS ECOLÓGICAS NO CEEP PROFESSOR FRANCISCO DE ASSIS PEDROSA." In VI Congresso Brasileiro de Ciências Biológicas. Revista Multidisciplinar de Educação e Meio Ambiente, 2025. https://doi.org/10.51189/vi-conbracib/55270.

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Silva, Fernanda Marinho, Sérgio Pugliesi de Matos, and Anfranserai Morais Dias. "RAS KOMBAT: Oficina de Robótica Aplicada com Competição em Feira de Santana." In Escola Regional de Computação Bahia, Alagoas e Sergipe. Sociedade Brasileira de Computação - SBC, 2024. https://doi.org/10.5753/erbase.2024.4504.

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O presente artigo descreve a realização de uma oficina, onde a atividade final foi uma competição de robôs sumô, programados pelo Blockly@rduino, uma plataforma de programação em blocos baseada na tecnologia Blockly, desenvolvida pela Google. O evento foi realizado no CEEP Áureo Filho de Oliveira para alunos da rede básica de ensino público na cidade de Feira de Santana, Bahia. O projeto faz parte das atividades organizadas pelo capítulo de robótica RAS (Robotics and Automation Society) do ramo IEEE - UEFS (Universidade Estadual de Feira de Santana).
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Barbosa, Danilo Rodrigues. "Os Desafios em Transformar Aulas Práticas, em Aulas na Modalidade de Ensino Remoto em Tempos de Pandemia." In Seminário de Educação a Distância da Região Centro-Oeste. Sociedade Brasileira de Computação, 2022. http://dx.doi.org/10.5753/seadco.2022.20398.

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O presente trabalho foi realizado através de vivência docente na área especificamente de informática, Tal trabalho foi experenciado no período de 01/04 a 30/09/2021, na escola CEEP José Pacífico de Moura Neto. O presente resumo traz aspectos acerca das atividades desempenhadas, participações realizadas, e ainda, traz uma visão real acerca do ensino de conteúdos computacionais tipicamente práticos, convertidos em modalidade de ensino remoto em tempos de pandemia. A metodologia desenvolvida foi dada a partir das observações e própria vivência quanto às práticas docente, isto é, lidando com os desafios do ensino, inseguranças e realidade social dos estudantes.
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Fish, Janet D. "Consumer of concern early entry program (C-CEEP): protecting against the biological suicidal warfare host." In SPIE Defense + Security, edited by Augustus W. Fountain. SPIE, 2014. http://dx.doi.org/10.1117/12.2048324.

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Almeida da Silva, Maura, Diego Francisco da Silva, Rafaela Campos Sousa, Samuel Vitor da Silva, and Francisca das Chagas Alves da Silva. "A IMPORTÂNCIA DO PIBID NA VISÃO DOS ALUNOS DO CENTRO ESTADUAL DE EDUCAÇÃO PROFISSIONAL PETRÔNIO PORTELA-CEEP, PICOS-PI." In IV CONGRESSO INTERNACIONAL DAS LICENCIATURAS PDVL 2017. Instituto Internacional Despertando Vocações, 2017. http://dx.doi.org/10.31692/2358-9728.ivcointerpdvl.2017.00269.

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Silva, Max Alexandre Da, ADRIANA APARECIDA DE SOUZA, and Dante Henrique Moura. "A MATERIALIZAÇÃO DO ENSINO MÉDIO INTEGRADO NO RIO GRANDE DO NORTE: UM ESTUDO SOBRE A INFRAESTRUTURA NO CEEP/PLG." In Anais do Colóquio nacional e colóquio internacional - a produção do conhecimento em educação profissional: em defesa do projeto de formação humana integral. Even3, 2021. http://dx.doi.org/10.29327/154159.6-12.

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Ferreira, Thaissa Morais, LUAN RODRIGUES DE SOUZA, ARIANE FLAVIA SILVA DOS SANTOS, GEÓRGIA DE SOUZA TAVARES, and RAIMUNDA CARDOSO DOS SANTOS. "UMA ANÁLISE SOBRE COMO AS MONITORIAS AUXILIAM NO DESEMPENHO DOS ALUNOS EM OLIMPÍADAS CIENTÍFICAS NO CEEP- LICEU PARNAIBANO – PARNAÍBA/PI." In II Congresso Brasileiro On-line de Pesquisa e Inovação em Educação. Revista Multidisciplinar de Educação e Meio Ambiente, 2023. http://dx.doi.org/10.51189/cinped2023/25440.

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Almeida da Silva, Maura, Diego Francisco da Silva, Renan Filho da Silva, Samuel Vitor da Silva, and Francisca das Chagas Alves da Silva. "I GINCANA DE QUÍMICA DO CENTRO ESTADUAL DE EDUCAÇÃO PROFISSIONAL PETRÔNIO PORTELA-CEEP, EM PICOS-PI, PARA O APRIMORAMENTO DOS CONHECIMENTOS QUÍMICOS." In IV Congresso internacional das licenciaturas. Instituto internacional despertando vocações, 2017. http://dx.doi.org/10.31692/2358-9728.ivcointerpdvl.2017.00545.

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Reports on the topic "CEEP"

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Kolev, T. CEED-MS10: Initial CEED API. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1845655.

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Kolev, T. CEED-MS8: Initial Integration of CEED Software in ECP Applications. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1845632.

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โขวิฑูรกิจ, วีรพันธุ์, วาณี เปล่งพาณิชย์, ปาล์ม ชาติยิ่งเจริญ та LeGoff, Wilfried. โครงการวิจัยการศึกษารหัสพันธุกรรมในคนไทยที่มีไขมันในเลือดชนิดเอชดีแอลสูงมาก โดยวิธีถอดรหัสและวิเคราะห์การเปลี่ยนแปลงหน้าที่. จุฬาลงกรณ์มหาวิทยาลัย, 2011. https://doi.org/10.58837/chula.res.2011.33.

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วัตถุประสงค์: ปัจจัยทางพันธุกรรมที่เกี่ยวข้องกับภาวะเอชดีแอลในเลือดสูงยังไม่เป็นที่เข้าใจแน่ชัด คณะผู้วิจัยทำการถอดรหัสพันธุกรรมยีน 3 ยีน คือ CETP, LIPC และ LIPG ซึ่งสร้างโปรตีน คอเลสเตอริล เอสเทอร์ ทรานสเฟอร์ โปรตีน, เฮบพาติค ไลเปส และ เอนทีเลียล ไลเปส ตามลำดับ ในคนไทยที่มีระดับเอชดีแอลในเลือดสูงมากเทียบกับประชากรกลุ่มควบคุมวิธีดำเนินการวิจัย คณะผู้วิจัยทำการถอดรหัสยีน CETP, LIPC และ LIPG ในส่วนของ exon และ exon-intron junctions เพื่อค้นหาการเปลี่ยนแปลงพันธุกรรมในคนไทย 64 คนที่มีระดับเอชดีแอล ≥ 2.59 มิลลิโมล/ลิตร (100 มิลลิกรัม/เดซิเมตร) และเปรียบเทียบกับผลในประชากรกลุ่มควบคุม 113 คนผลการวิจัย ใน coding region ของยีน CETP พบมีการเปลี่ยนแปลงที่ไม่เคยมีการรายงานมาก่อน 2 ตำแหน่ง คือ deletion mutation ใน exon 9 (c.785-788 delTCCC หรือ p.Leu262ProfsX31) และ duplication mutation ใน exon 13 (c.1226-1230 dupAGACT หรือ p.Val411ArgX6) และพบการเปลี่ยนแปลงที่ไม่เคยมีการรายงานมาก่อนอีก 4 ตำแหน่งในส่วนของ CETP promoter ได้แก่ 18-bp deletion mutation (g.4989-5006delGGGCGGACATACATATAC) 1 ตำแหน่งและ point mutation 3 ตำแหน่ง (g.4982G &gt; T, g.4961C &gt; T และ g.4659C &gt; T) ในยีน LIPC พบมีการเปลี่ยนแปลงที่ไม่เคยมีการรายงานมาก่อนแบบ missense mutations 2 ตำแหน่ง คือ p.Gly141Ser และ P.Val173Met การเปลี่ยนแปลงทางพันธุกรรมดังกล่าวไม่พบในกลุ่มควบคุมเลย การทดลองทำ site-directed mutagenesis และศึกษาการเปลี่ยนแปลงหน้าที่ในระดับเซลล์ พบว่าการเปลี่ยนแปลง 18-bp deletion mutation mutagenesis และศึกษาการเปลี่ยนแปลงหน้าที่นระดับเซลล์ พบว่าการเปลี่ยนแปลง 18-bp deletion mutation ที่ CETP promoter มีผลทำให้ transcriptional activity ลดลง นอกจากนี้ พบว่าการเปลี่ยนแปลงที่พบบ่อยในยีน CETP คือ p.Asp459Gly หรือ D459G ที่พบบ่อยกว่าอย่างมีนัยสำคัญในกลุ่มคนไข้ที่มีระดับเอชดีแอลสูงเทียบกับกลุ่มควบคุม (23% และ 4% ตามลำดับ, P &lt; 0.0001) สำหรับในยีน LIPGไม่พบการเปลี่ยนแปลงทางพันธุกรรมใหม่สรุป คณะผู้วิจัยพบการเปลี่ยนแปลงทางพันธุกรรมที่ไม่เคยมีรายงานมาก่อนในยีน CETP และ LIPC ในกลุ่มคนที่มีระดับเอชดีแอลสูง การเปลี่ยนแปลงทางพันธุกรรมในยีน CEPT และ LIIPC ทั้งแบบที่พบใหม่และที่มีการรายงานมาก่อน พบได่ประมาณ 1 ใน 3 ของคนที่มีระดับเอชดีแอลสูงดังกล่าว
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Kolev, T. CEED-MS37: Port and optimize the CEED software stack to Aurora/Frontier EA. Office of Scientific and Technical Information (OSTI), 2021. http://dx.doi.org/10.2172/1822610.

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Kolev, T. CEED-MS34: Improve performance and capabilities of CEED-enabled ECP applications on Summit/Sierra. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1614965.

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Kolev, T. Engage second wave ECP/CEED applications. Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1845634.

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Ren, Gang. How Different CETP Inhibitors Effect on CETP Conformation and its Function in CE Transfer among Various Overall Period of Performance. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1395360.

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Bowers, John. Center for Energy Efficient Materials (CEEM) (Final Technical Report). Office of Scientific and Technical Information (OSTI), 2014. http://dx.doi.org/10.2172/1169473.

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Kolev, T. Performance tuning of CEED software and first wave apps. Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1845653.

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Jones, Kristin, Nichole Sather, and Heida Diefenderfer. CEERP SM3 Research, Monitoring, and Evaluation Workshop: Summary Report. Office of Scientific and Technical Information (OSTI), 2024. http://dx.doi.org/10.2172/2476504.

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