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Lecea, Romera Mercedes. "Stereoselective synthesis of the natural metabolite of tocopherol, (S)-y-CEHC, and monofluorinated trisubstituted olefins." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-01064056.
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This PhD work has been focused in two different subjects : - The stereoselective synthesis of 2,2-disubstituted chroman moiety assisted by sulfoxides as only source of chirality has been realized with good yields and good diastereoselectivities. The total synthesis of the natural metabolite of tocopherol, (S)-γ-CEHC, has been realized in ten steps and in 18.4% of overall yield using as key step the formation of ally sulfinyl chroman by reaction with allyl trimethyl silane in the presence of a Lewis acid. - The stereoselective synthesis of monofluorinated trisusbtituted olefins has been realized in moderated yields and excellents selectivities in some cases (95 :5) from readily available 3,3,3-trifluoropropionates.The Diels-Alder reaction using fluorinated dienophiles and cyclopentadiene led to unexpected complex structures.
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Pfluger, Paul Thomas. "Der Metabolismus der Tocopherole und Tocotrienole." Phd thesis, kostenfrei, 2007. http://opus.kobv.de/ubp/volltexte/2008/1601/.
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Letelier, Valle José Francisco. "CEAC: centro de apoyo cultural." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/111197.
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La presente memoria posee como finalidad interiorizar en el desarrollo y comprensión del proyecto de Arquitectura llevado a cabo durante el proceso de Titulación, en base a la problemática sobre los efectos urbanos de la edificación en altura en la ciudad.
De tal manera, se elabora un proyecto trendsetter que explore dichas problemáticas y genere una nueva tipología de hacer ciudad vertical. Teniendo como objetivo que el barrio adquiera un nuevo valor y potencie tanto su dinámica como su propia identidad.
La resolución del proyecto se origina a partir de la comprensión de los trendsetters como elementos que generan tendencia en lugares y barrios que se desean activar como polos de actividades, de manera que el sector pase de un estado neutro a un estado de prosperidad.
El barrio seleccionado para su análisis e intervención es el Barrio El Golf, por ser el principal escenario influenciado por desarrollos de mercado y su edificación en altura, modificando su configuración urbana residencial hacia un polo de actividad financiera; Se define un emplazamiento especifico a intervenir, por ser un punto estratégico de entrada al barrio por metro, por su conexión con plaza Perú y su posicionamiento sobre la calle principal Isidora Goyenechea.
Finalmente, tras un exhaustivo análisis de las carencias y necesidades del sector, surge un mix programático constituido por la integración de actividades de formación, información, recreación y trabajo. Todos juntos dan origen al CENTRO DE APOYO CULTURAL _ CEAC proporcionando ser un lugar de encuentro en el barrio y un apoyo para la biblioteca comunal de Las Condes, que busca permanecer en el tiempo, generando nuevas tendencias y usos en el sector.
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Fortune, Tyler John. "CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX." The University of Montana, 2008. http://etd.lib.umt.edu/theses/available/etd-12172007-145904/.
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Low-level lead (Pb) exposure is associated with behavioral and cognitive dysfunction. It is not clear how Pb produces these behavioral changes but low-level Pb exposure and learning disabilities have been associated with altered auditory temporal processing in both humans and animals. Temporal processing is used to decode complex sounds and to detect a signal within a noise background, and it is thought that neurons of the superior olivary complex (SOC) in the brainstem play a role in sound detection in noisy environments and in selective auditory attention. The SOC receives a catecholaminergic and a serotonergic innervation from the locus coeruleus and the dorsal raphe respectively. While the physiological role of the noradrenergic input has yet to be defined, serotonin is involved in auditory temporal processing. Because Pb exposure modulates auditory temporal processing, the serotonergic system is a potential target for Pb. The current study was undertaken to determine whether developmental Pb exposure preferentially changes the expression of serotonin within the SOC. Pb-treated mice were exposed to no Pb, 0.01 mM (very low) or 0.1 mM (Low) Pb acetate throughout gestation and through 21 days postnatally. Brainstem sections from control and Pb-exposed mice were immunostained for the vesicular monoamine transporter 2 (VMAT2), serotonin, and dopamine beta hydroxylase (DβH, a marker for norepinephrine) in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with antibodies to VGLUT1, VGAT and VAChT in order to determine whether Pb exposure alters the glutaminergic, gaba-ergic, or cholinergic systems. Pb exposure caused a significant decrease in VMAT2, 5HT, and DβH expression while VGLUT1, VGAT and VAChT showed no change. These results provide evidence that Pb exposure during development alters normal monoaminergic expression in the auditory brainstem.
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Forestier, François. "Plaquette et CEC. : Atteinte plaquettaire en chirurgie cardiaque avec CEC : aspects physiopathologiques, prévention, détection et traitement." Bordeaux 2, 1998. http://www.theses.fr/1998BOR23017.
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Boughtflower, Robert J. "Operating parameters for capillary electrochromatography (CEC)." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/12403.
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Miniaturisation of chromatographic systems is becoming increasingly desirable. Future developments will demand the analysis of smaller samples, at faster rates, with increasingly complex separations required. These demands are already starting to exceed the capabilities of conventional HPLC systems. Systems will require more column efficiency, operation at higher flow rates and detection of the undiluted eluent in the most sensitive detectors available. CEC offers the opportunity to achieve these goals. The main obstacles to using CEC reliably are the relatively unstable nature of purely electrically driven flows in packed beds, the lack of good quality CEC columns and the lack of dedicated instruments to perform CEC analysis. Also, CEC shares some of the same problems with HPLC of miniaturising the separation system without incurring dispersion related losses. The work detailed in this thesis contributes considerable advancements in most of these areas. Novel methods to produce high quality columns are described. The work demonstrates effective methods for coupling CEC to MS that make allowance for control of dispersion. The thermal limits of operation are discussed and demonstrated. Pressure-assisted CEC, demonstrating the practicality of performing CEC based analysis that is as reliable as current HPLC systems is shown. Proper optimisation of these type of uses will ultimately deliver CEC in a reliable format which will encourage a whole new audience of users to reap the benefits available.
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Martinot, Stéphane. "Comportement oxymétrique et hémodynamique du foetus ovin in utero sous CEC pulsatile : comparaison avec la CEC continue." Lyon 1, 1995. http://www.theses.fr/1995LYO1T128.
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Adams, Peter. "Algebraic topics in the Stone-Cech compactification of discrete semigroups." Thesis, University of Hull, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395633.
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Norton, Dean Stephen. "Capillary Electrochromatography-Mass Spectrometry (CEC-MS) of Surfactants." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/chemistry_diss/13.
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This research presents advancements in the coupling of capillary electrochromatography (CEC) to mass spectrometry (MS) for the analysis of different chemical classes of surfactants. Chapter 1 provides a brief introduction that summarizes the mechanics and fundamentals of CEC, including instrumentation and applications for CEC-MS. Chapter 2 describes the on-line hyphenation of a packed CEC column with an internally tapered tip coupled to electrospray ionization-mass spectrometry (ESI-MS) and atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) for the analysis of betaine-type amphoteric or zwitterionic surfactants (Zwittergent®). The interesting aspects include CEC-MS column manufacture and charaterization, as well as a comparison between the CEC-ACPI-MS and CEC-ESI-MS ionization pattern of zwittergents. In Chapter 3, the CEC-MS of alkyltrimethyl-ammonium ions (ATMA+) with chain length ranging from C1-C18 is optimized using an internally tapered CEC-MS column packed with mixed mode C6/strong cation exchange stationary phase and coupled to an ESI source. In addition, the optimized CEC-ESI-MS protocol is applied for the challenging analysis of commercial sample Arquad S-50 ATMA+ containing cis-trans unsaturated and saturated soyabean fatty acid derivatives. In Chapter 4, a novel CEC-UV method for separation of the various Triton X-100 oligomers is presented. A systematic mobile phase tuning and comparison of monomeric vs. polymeric stationary phases was conducted. In Chapter 5, we present the first application of CEC coupled to MS for analysis of Triton X (TX-) series surfactants. A characterization from the viewpoint of the ion and adduct formation for TX-series nonionic surfactants with a variable number of ethoxy units (n=1.5-16) in the scan mode are first discussed. Next, utilizing the TX-series as model alkylphenolpolyethoxylates (APEOs), a detailed investigation of the chromatographic separation and MS detection are performed followed by analysis of very long chain TX series with n=30-70. In Chapter 6, CEC-MS utilizing full scan positive ion mode of ESI was employed to study the effect of fragmentor voltage on the in-source collision induced dissociation (IS-CID) of several APEO nonionic surfactants. Finally, in Chapter 7, the preparation and characterization of a novel liquid crystalline stationary phase suitable for separation of neutral and charged compounds in packed column CEC is evaluated.
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Salinas, David. "Reconstruction en grandes dimensions." Phd thesis, Université de Grenoble, 2013. http://tel.archives-ouvertes.fr/tel-00947303.
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Dans cette thèse, nous cherchons à reconstruire une approximation d'une variété connue seulement à partir d'un nuage de points de grande dimension l'échantillonnant. Nous nous efforçons de trouver des méthodes de reconstructions efficaces et produisant des approximations ayant la même topologie que la variété échantillonnée. Une attention particulière est consacrée aux flag-complexes et particulièrement aux complexes de Rips. Nous montrons que le complexe de Rips capture la topologie d'une variété échantillonnée en supposant de bonnes conditions d'échantillonnage. En tirant avantage de la compacité des flags-complexes qui peuvent être représentés de manière compacte avec un graphe, nous présentons une structure de données appelée squelette/bloqueurs pour complexes simpliciaux. Nous étudions ensuite deux opérations de simplifications, la contraction d'arête et le collapse simplicial, qui s'avèrent utiles pour réduire un complexe simplicial sans en changer sa topologie.
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Breuss, Fritz. "Balassa-Samuelson effects in the CEEC. Are they obstacles for joining the EMU?" Forschungsinstitut für Europafragen, WU Vienna University of Economics and Business, 2003. http://epub.wu.ac.at/198/1/document.pdf.
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A phantom is haunting the EU enlargement process. Some fear that the Balassa-Samuelson (B-S) effect might be a major obstacle for the Central and Eastern European countries (CEEC) to become members of the Economic and Monetary Union (EMU). A review of the relevant literature reveals that most estimations of the B-S effect in the EU acceding countries are flawed by one kind or the other. Either they do not estimate correctly the B-S propositions, or if they measure it they use a variety of measures for the variables needed. Additionally, the B-S effect is only a special case of a broader approach towards equilibrium real exchange rates. Lastly the B-S effect is studied in a CGE multi-country world in order to detect possible spillover effects. After describing the "official" road map towards the EMU, it is concluded that the uncertainties in measuring the B-S are much too high in order to see in it (alone) a major hindrance for the CEEC to become early members of the EMU. Moreover, real exchange rate appreciations that reflect productivity gains in the tradable sector are an equilibrium phenomenon and do not require a policy response. They are a natural phenomena in catching-up countries like the CEEC. Furthermore, the official doctrine for entering the EMU by the EU/ECB only interdicts depreciations but not appreciations for potential EMU members. (author's abstract)Series: EI Working Papers / Europainstitut
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Combe, Noémie. "On a new cell decomposition of a complement of the discriminant variety : application to the cohomology of braid groups." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0140.
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Cette thèse concerne principalement deux objets classiques étroitement liés: d'une part la variété des polynômes complexes unitaires de degré $d>1$ à une variable, et à racines simples (donc de discriminant différent de zéro), et d'autre part, les groupes de tresses d'Artin avec d brins. Le travail présenté dans cette thèse propose une nouvelle approche permettant des calculs cohomologiques explicites à coefficients dans n'importe quel faisceau. En vue de calculs cohomologiques explicites, il est souhaitable d'avoir à sa disposition un bon recouvrement au sens de Čech. L'un des principaux objectifs de cette thèse est de construire un tel recouvrement basé sur des graphes (appelés signatures) qui rappellent les `dessins d'enfant' et qui sont associées aux polynômes complexes classifiés par l'espace de polynômes. Cette décomposition de l'espace de polynômes fournit une stratification semi-algébrique. Le nombre de composantes connexes de chaque strate est calculé dans le dernier chapitre ce cette thèse. Néanmoins, cette partition ne fournit pas immédiatement un recouvrement adapté au calcul de la cohomologie de Čech (avec n'importe quels coefficients) pour deux raisons liées et évidentes: d'une part les sous-ensembles du recouvrement ne sont pas ouverts, et de plus ils sont disjoints puisqu'ils correspondent à différentes signatures. Ainsi, l'objectif principal du chapitre 6 est de ``corriger'' le recouvrement de départ afin de le transformer en un bon recouvrement ouvert, adapté au calcul de la cohomologie Čech. Cette construction permet ensuite un calcul explicite des groupes de cohomologie de Čech à valeurs dans un faisceau localement constantThis thesis mainly concerns two closely related classical objects: on the one hand, the variety of unitary complex polynomials of degree $ d> 1 $ with a variable, and with simple roots (hence with a non-zero discriminant), and on the other hand, the $d$ strand Artin braid groups. The work presented in this thesis proposes a new approach allowing explicit cohomological calculations with coefficients in any sheaf. In order to obtain explicit cohomological calculations, it is necessary to have a good cover in the sense of Čech. One of the main objectives of this thesis is to construct such a good covering, based on graphs that are reminiscent of the ''dessins d'enfants'' and which are associated to the complex polynomials. This decomposition of the space of polynomials provides a semi-algebraic stratification. The number of connected components in each stratum is counted in the last chapter of this thesis. Nevertheless, this partition does not immediately provide a ''good'' cover adapted to the computation of the cohomology of Čech (with any coefficients) for two related and obvious reasons: on the one hand the subsets of the cover are not open, and moreover they are disjoint since they correspond to different signatures. Therefore, the main purpose of Chapter 6 is to ''correct'' the cover in order to transform it into a good open cover, suitable for the calculation of the Čech cohomology. It is explicitly verified that there is an open cover such that all the multiple intersections are contractible. This allows an explicit calculation of cohomology groups of Čech with values in a locally constant sheaf
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Clarke, Channine. "Occupational therapy students' experiences of role-emerging placements and their influence on professional practice." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/a61504f4-cecc-4d7b-8e09-879ab99a4161.
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Changes in health and social care present exciting opportunities for occupational therapists to expand their practice into innovative settings. To prepare graduates for these opportunities, placement experiences must reflect current trends in practice. Role-emerging placements are increasingly being used to help students develop the skills, knowledge and attributes needed to become the therapists of tomorrow. Whilst the literature on role-emerging placements is increasing, studies have tended to be general placement evaluations, with limited studies exploring students' experiences in detail. No studies have explored the influence of role-emerging placements on graduates' professional practice and identity. This study adopted a phenomenological design to gain a deeper understanding of how occupational therapy students experience and ascribe meaning to role-emerging placements and the ways in which such placements influence their professional practice and identity once qualified. In-depth initial interviews were carried out with five MSc pre-registration occupational therapy students within one month of having undertaken a role-emerging placement. Follow-up interviews were carried out six months after the students had graduated and gained employment. Interviews were audio taped, transcribed and analysed using Interpretative Phenomenological Analysis (IPA). Key findings reveal that the role-emerging placements acted as a strong catalyst for the students' ontological development. Through engaging in challenging and autonomous learning experiences, they developed deeper insights of who they were becoming as professionals. This led to a professional identity that was of their own making. Having to continually reflect on and verbalise the core essence and contribution of occupational therapy, students developed clarity of understanding about the uniqueness of the profession. This is an important finding in light of the historical difficulty occupational therapists have had articulating their unique role and professional identity. Once qualified, participants had mixed experiences concerning the extent to which they were able to sustain this identity and enact practice in a way that was meaningful to them. A significant finding was the difficulty that graduates experienced working in NHS settings where the nature of occupational therapy practice restricted their ability to work in a way that was congruent with the professional way of being that they had developed during their placement. Consideration therefore needs to be given to the nature of occupational therapy practice in traditional settings. Recommendation is made for role-emerging placements to be made compulsory for all occupational therapy students to assist them in their ontological development and prepare them more effectively for practice. Further research into the long-term influence of such placements, in particular on graduates' practice and identity, is required.
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Marks, Lori J. "Meeting CEC and NCATE Teacher Education Standards with Limited Resources." Digital Commons @ East Tennessee State University, 1996. https://dc.etsu.edu/etsu-works/3567.
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Souza, Josiney Alves de. "Ações de semigrupos : recorrencia por cadeias em fibrados e compactificações de Ellis." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/305813.
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Orientador: Luiz Antonio Barrera San MartinTese (doutorado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica
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Resumo: Um semigrupo de transformação consiste de um semigrupo de aplicações contínuas definidas num espaço topológico. A hipótese sobre o semigrupo é a propriedade de reversibilidade, isto é, que a coleção das translações do semigrupo satisfaz a propriedade de intersecção finita. A idéia central é de dinamizar um semigrupo de transformação, sendo isto realizado pela introdução dos correspondentes objetos dinâmicos elementares da teoria de semifluxos, ou seja, os conjuntos limites, atratores e repulsores. O conceito de recorrência por cadeias é abordado de uma forma generalizada, sobre espaços paracompactos, tendo como fundamento certas famílias especiais de coberturas abertas do espaço base chamadas famílias admissíveis. Estudamos também ações de grupos de homeomorfismos sobre espaços compactos. Neste caso, a hipótese sobre o grupo é que ele seja gerado por um subsemigrupo reversível, a partir do qual são definidos todos os objetos dinâmicos elementares. Estudamos dois casos específicos de semigrupos de transformações. No primeiro caso, abordamos semigrupos de transformações em fibrados topológicos, especialmente em fibrados flag, e enfatizamos o estudo sobre transitividade por cadeias fibra a fibra. No segundo caso, estudamos ações de grupos sobre compactificações de Ellis, onde apresentamos uma relação entre o conceito de subsemigrupo semitotal e a transitividade por cadeias. Por último, introduzimos o conceito de função recorrente por cadeias, generalizando o conceito de função recorrente.
Abstract: Transformation semigroups are actions of semigroups of continuous maps on topological spaces. We consider reversible semigroups and study dynamics behaviors by introducing the elementary dynamic objects, originals of the semiflows theory, that is, the limit sets, attractors and repellers. We present the concept of chain recurrence for admissible families on paracompact spaces. We also study homeomorphism group action on compact spaces. In this case, the hypothesis on the group is the Ore's condictions. The elementary dynamics objects are defined from the action of the generator reversible subsemigroup. Then we study two specific cases of transformation semigroups. In the first case, we present results on the actions of endomorphism in flag bundles by emphasizing the chain transitivity in the fibres. Next, we study group actions in Ellis compactifications and relate the concept of semitotal subsemigroup to the chain transitivity. Finally, we introduce the concept of chain recurrent function and generalize the concept of recurrent function.
Doutorado
Geometria
Doutor em Matemática
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Vacek, Jiří. "Podnikatelské příležitosti ve stavebnictví vybraných zemí střední a východní Evropy." Doctoral thesis, Vysoká škola ekonomická v Praze, 2005. http://www.nusl.cz/ntk/nusl-125223.
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The Ph.D. thesis deals with the construction research methodology and performed research, and the analysis of business opportunities in the construction industry of the selected Central and Eastern European countries. The thesis is divided into two parts. The first part focuses on the description and specification of the main categories -- general market research methodology, the description and statistical methodology used by the Czech Statistical Office, and their comparison with our research methods (advantages, disadvantages, and benefits). This part also mentions specific features of construction industry which need to be taken into account when performing the research and evaluating the results for the purposes of the development of business opportunities in the construction industry. The second part of the thesis analyses the particular results of the construction industry research carried out in the Czech Republic, Slovakia, Poland, and Hungary in 2006--2012 (with more than 2,500 research interviews). It brings a comparison of the Eurostat/statistical offices published data vs. the analysed developments in particular years predicted by the construction company top management (both the biggest and middle/small construction companies) throughout the analysed regions, and the impact of their predictions on the company behaviour in the selected spheres of the entrepreneur environment. The analyses bring the comparison of the methods by means of which the companies acquire new business orders, the extent of transparency and/or corruption in particular countries, changes during the economic crisis, the extent of company risk and key priorities on particular markets, as well as the comparison of the key limitations that have the main impact on the economic results of the construction company. Using the originally developed methodology and the model of research implementation, the thesis provides the analyses of considerably reliable information about the operation and behaviour of the construction companies on the market in the neighbouring countries, as well as the necessary insight which can facilitate the expansion of the Czech companies into the selected countries. At the same time, the construction research model has been verified in practice by regular construction research studies which assist construction companies in their decision making and orientation on the changeable construction markets both in the Czech Republic and in other selected countries. The outcomes and results of particular research studies have been presented and discussed during the regular 'Encounters of Czech, Slovak, and Polish Construction Leaders' by the construction company top management as well as by the representatives of the government of particular countries. The thesis outcomes prove that the originally developed methodology applied in the follow-up research can facilitate and provide relevant and high-quality predictions about the developments in construction industry, which can be successfully used by the top management in their decisions on the future prospects of their company business opportunities in Central and Eastern European countries. Currently, more than 4,700 users in the Czech Republic make use of the particular research studies on the developments in construction in the Czech Republic and in other selected countries. As results from the carried out research, it is possible for the Czech construction companies to make use of business opportunities and to expand to neighbouring countries, especially to Slovakia and Poland, and, with regard to geographical closeness of the researched markets and considerable similarity of construction works/applied technologies, thus compensate for a plunge in domestic orders by the export of construction works. Specialized construction companies with higher business value-added will have the biggest potential.
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Celik, Goknur. "University Continuing Education Units For Local Development: The Case Of Metu Cec." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608895/index.pdf.
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The aim of this thesis is to point out the critical position of University Continuing Education Units in the context of knowledge economy for their contribution to local development, and to analyse to what extent these units in the case of Turkey serve for this function.
For this purpose, first, the nature of knowledge economy and transformations initiated in this process in labour markets and in nature of education are analysed. Next, new understanding of lifelong learning and restructuring process in universities, which are connected with transformation in these two fields, are discussed. Later, position of cities and importance of urban policy for local development within the context of knowledge economy is examined. Consequently, as a product of these intertwined transformations, it is revealed that University Continuing Education Units appear to be key actors for cities for their contribution to local development. Then, based on the facts developed in the theoretical argumentsdata of University Continuing Education Units of Turkey and Middle East Technical University Continuing Education Center (METU CEC) scrutinised in order to reveal how far these units in Turkey serve for local development. Finally, findings and conclusions are summarised, and policy proposals are developed for University Continuing Education Units should follow in order to serve local development effectively.
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Hwang, Jong Seo. "Analysis of effectiveness of CEC (Cooperative Engagement Capability) using Schutzer's C2 theory." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2003. http://library.nps.navy.mil/uhtbin/hyperion-image/03Dec%5FHwang.pdf.
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Thesis (M.S. in Operations Research)--Naval Postgraduate School, December 2003.Thesis advisor(s): Eugene P. Paulo, Jae Yeong Lee, Russell Gottfried. Includes bibliographical references (p. 57). Also available online.
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Aymard, Thierry. "Intérêt de la thoracotomie gauche sans CEC dans la revascularisation coronaire itérative." Montpellier 1, 1999. http://www.theses.fr/1999MON11021.
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DOMINGUEZ, PEREZ ROBERTO. "Etude de la structure tridimensionnelle de l'endoglucanase celc et de la xylanase xynz de clostridium thermocellum." Paris 11, 1996. http://www.theses.fr/1996PA112055.
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La cellulose est le polysaccharide le plus abondant dans les membranes des cellules des plantes. Pour degrader la cellulose naturelle, les microorganismes cellulolytiques ont developpe une grande variete d'enzymes avec des specificites et des structures tridimensionnelles differentes. Les cellulases et les hemicellulases representent environ un tiers des enzymes glycosidiques, qui peuvent etre classees en plus de 50 familles en fonction de leurs similitudes de sequences. La bacterie anaerobie clostridium thermocellum, l'un des microorganismes cellulolytiques les mieux etudies, produit un complexe multienzymatique de haut poids moleculaire, le cellulosome, qui est tres actif sur la cellulose cristalline. Nous avons determine la structure tridimensionnelle a 2. 15 a de resolution de l'endoglucanase celc sauvage, appartenant a la famille la plus importante de cellulases (famille 5 des glycosyl hydrolases). La proteine se replie en un tonneau (/)#8 avec une profonde cavite, generee par l'insertion d'un sous-domaine compose majoritairement d'helices-, a l'interieur de laquelle se situe le site actif. La structure du domaine catalytique de la xylanase xynz de clostridium thermocellum, qui appartient a la famille 10 des glycosyl hydrolases, a ete determinee a 1. 4 a de resolution. Malgre des differences significatives dans la specificite vis-a-vis du substrat et l'absence d'homologie de leurs sequences, le schema general de repliement polypeptidique, l'architecture du site actif et le mecanisme catalytique de xynz et de celc sont similaires, ce qui suggere l'existence d'une origine evolutive commune. De plus, la superposition des structures de xynz et de celc avec celles d'autres enzymes glycosidiques appartenant a d'autres familles qui presentent un repliement du meme type, fournit des arguments supplementaires a l'existence d'une relation evolutive entre les familles de glycosyl hydrolases repliees en tonneau (/)#8. La structure du mutant glu140->gln de celc libre (celc#e#1#4#0#q) et en complexe avec le cellohexaose (celc#e#1#4#0#q-glc#6) ont ete determinees respectivement a 1. 9 a et 2. 3 a de resolution. La comparaison des structures libres et complexee revele des changements de conformation lies a la fixation du substrat, parmi lesquels une reorientation significative de la boucle 138-141 qui porte le residu catalytique glu140 dans l'enzyme sauvage
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ALMEIDA, NETO Adauto. "Papiloma vírus humano e o polimorfismo do códon 72 (Alelo-G) do gene TP53 no carcinoma escamoso oral." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/9031.
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Previous issue date: 2007O CEC oral representa 90% de todos os tumores malignos que afetam a boca. A infecção por HPV (Papilomavírus Humano) demonstrou ser um fator relevante no desenvolvimento do carcinoma oral, assim como o polimorfismo do Códon 72 (alelo-G) do gene TP53, cuja transcrição da proteína supressora tumoral p53 é modificado. A degradação da p53 ocorre em função da interação entre a oncoproteína viral E6 junto ao sistema proteolítico ubiqütina-proteossômica. O objetivo deste trabalho foi identificar a presença do HPV no CEC oral e verificar a associação com o polimorfismo do códon 53 do gene TP53 . O grupo experimental foi composto por 24 pacientes com CEC oral , os quais freqüentavam a rotina do Hospital do Câncer de Pernambuco. O grupo controle fora composto por 21 indivíduos que apresentavam o mesmo ambiente familiar e as mesmas relações sociais dos pacientes estudados. O material biológico foi obtido pela esfoliação da mucosa oral e o DNA extraído através do método de Salting Out. A detecção do HPV foi realizada por PCR a partir da utilização dos primers GP5 + GP6 +. A identificação do polimorfismo do códon 72 (alelo-G) foi feita por PCR - RFLP. Os resultados foram negativos para a presença do HPV. Não foi observada associação entre a presença do polimorfismo alelo-G nos pacientes com CEC oral na amostra avaliada (X2 = 4,048; P = 0,132). Os resultados confirmaram que os homens (X2 = 5,88; P = 0,01) e fumantes (X2 = 8,84; P = 0,002) apresentaram uma maior freqüência de diagnóstico positivo para o CEC oral, assim como foram encontrados valores estatisticamente significativos para a idade dos indivíduos estudados (X = 5,88; P = 0,01). Os resultados não sugerem uma associação com o polimorfismo do gene TP53 (alelo-G) e da infecção por HPV com CEC oral. Os resultados para o sexo e tabagismo estão de acordo com a literatura científica
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Larsson, Hanna, and Emma Harrtell. "Does choice of transition model affect GDP per capita growth?" Thesis, Jönköping University, JIBS, Economics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-1000.
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Efter upplösningen av Sovjetunionens starka maktkontroll över sina satellitstater den 9:e november 1989, kunde de Centrala och Östeuropeiska länderna (förkortning CEEC på engelska) påbörja sin övergång till marknadsekonomi. Sättet att närma sig en fri marknad är indelat i två olika tillvägagångssätt – chockterapi och gradualism. Den förstnämda metoden genomförs med fokus på snabbhet och en samverkande engångsförvandling av de ekonomiska sektorerna medan den sistnämnda beaktar en grad- och stegvis omvandling. Omvandlingsprocessen i sig består av flera variabler, exempelvis privatisering av statligt ägd egendom, makroekonomisk stabilitet samt liberalisering av priser och handel. Beroende på vilken metod som valdes genomfördes de ovan nämnda variablerna vid olika tidpunkter och med varierande hastighetsgrad. Åsikterna bland ekonomer rörande vilken metod som uppnått bäst resultat är omdebatterad. Följaktligen är syftet med denna uppsats att undersöka vilken av omvandlingsmetoderna som har uppnått högst BNP per capita tillväxt i de valda CEEC under perioden 1992-2003. Tio CEEC valdes ut för att få en rättvis delning mellan de två tillvägagångssätten, med tillhörande fem länder i varje grupp. Därtill valdes fem referensländer ut, för att i en grafisk analys kunna relatera utvecklingen i omvandlingsländer till redan etablerade marknadsekonomier. De erhållna resultaten visar att val av tillvägagångssätt inom omvandlingsprocessen inte har någon signifikant inverkan på BNP per capita utvecklingen. Ländernas grundförutsättningar samt i vilken ordning variablerna implementerades visar sig troligen ha större inverkan på BNP per capita tillväxten. Dessutom visar de empiriska resultaten klara indikationer på att det finns en skillnad mellan CEEC och referensländerna.
After the resolution of the Soviet Unions strict control over its satellite with beginning on the 9th of November 1989, the Central and Eastern European Countries (CEEC) began their transition towards a market economy. How to approach the economic system of a free market has been divided into two major policies – shock therapy and gradualism. The first policy is implemented with speed and one-shock change within the economic sectors as a focus while the second constitutes of slow and gradual implementations. The transformation process in itself consists of several variables, for e.g. privatization of state-owned properties, macroeconomic stabilization and liberalization of prices and trade. Depending on what policy chosen, the variables were implemented at different times and with different speed. The views among economists regarding which of the two models that achieve the best result when transforming differs widely. Hence, the purpose of this thesis is to investigate which of the two models that have had the best effect upon the GDP per capita growth in the chosen CEEC. Ten CEEC were picked to have a fair representation for each policy, with five countries representing each policy group and the years measured were 1992-2003. In addition, for a graphical analysis to be performed and to distinct CEEC from already established market economies, five reference countries were included. The results obtained indicate that the policy choice has no impact on average GDP per capita growth. Instead we concure with earlier research that claim that preconditions and sequential order of the market reforms have a larger impact on GDP per capita growth. Additionally, empirical results indicated that there is a significant difference in the GDP growth over the last decade between our CEEC and the reference countries.
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Karatas, Sinem Ayse. "Remainders and Connectedness of Ordered Compactifications." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1156.
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The aim of this thesis is to establish the principal properties for the theory of ordered compactifications relating to connectedness and to provide particular examples. The initial idea of this subject is based on the notion of the Stone-Cech compactification.The ordered Stone-Cech compactification oX of an ordered topological space X is constructed analogously to the Stone-Cech compactification X of a topological space X, and has similar properties. This technique requires a conceptual understanding of the Stone-Cech compactification and how its product applies to the construction of ordered topological spaces with continuous increasing functions. Chapter 1 introduces background information.
Chapter 2 addresses connectedness and compactification. If (A;B) is a separation ofa topological space X, then (A 8 B) = A 8 B, but in the ordered setting, o(A 8 B)need not be oA 8 oB. We give an additional hypothesis on the separation (A;B) tomake o(A 8 B) = oA 8 oB. An open question in topology is when is X -X = X. Weanswer the analogous question for ordered compactifications of totally ordered spaces. So, we are concerned with the remainder, that is, the set of added points oX -X. Wedemonstrate the topological properties by using lters. Moreover, results of lattice theory turn out to be some of the basic tools in our original approach.
In Chapter 3, specific examples and counterexamples are given to illustrate earlierresults.
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Segura, Ahumada Ximena. "CEAC : proyecto de con-formación centro de extensión artística y cultural, campus Andrés Bello - Universidad de Chile." Tesis, Universidad de Chile, 2004. http://www.repositorio.uchile.cl/handle/2250/111803.
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Memoria (arquitecto)Este proyecto de título, pretende contribuir la retroalimentación que se produce entre la Universidad como entidad fundamental en el desarrollo de la identidad nacional,y la ciudad, generando distintos grados de encuentro entre la ciudadanía y las expresiones que ella produce. Para esto, es necesario que su aporte cultural sea a través de un Centro de Extensión que sea parte de la ciudad. Así, tanto la imagen de este Centro, como la de la Universidad, actuarían como entes integrados se verían potenciados con un proyecto de arquitectura que ayude a esta conformación. Por otro lado, es necesario integrar este Centro de Extensión a la vida cotidiana de la Ciudad, reconociendo las características del lugar donde se emplace, vinculándose con él, generando, por lo tanto, diálogos a través de su morfología y, de la misma manera, aportar con áreas para el diálogo y el encuentro de los grupos que las utiliza. Por último, el propósito de la presente Memoria de Título, ha sido establecer un orden de las ideas sobre los temas que confluyen en el proyecto.
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Paterson, Clare Jane. "The development of capillary electrochromotography (CEC) and its coupling with electrospray mass spectroscopy." Thesis, Manchester Metropolitan University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266530.
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Santos, Anderson Fraga dos. "O modelo de controle estratégico de custos CEC e o ambiente hospitalar filantrópico." Universidade do Vale do Rio do Sinos, 2007. http://www.repositorio.jesuita.org.br/handle/UNISINOS/2820.
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Esta dissertação tem o propósito de verificar a aplicabilidade do modelo referencial avançado de controle estratégico de custos (CEC) (Diehl, 2004) no contexto hospitalar universitário filantrópico. O primeiro capítulo faz uma contextualização do tema e da problemática do controle estratégico de custos neste ambiente. O segundo capítulo apresenta o cenário dos serviços hospitalares no Brasil, focando os hospitais universitários e filantrópicos. O terceiro capítulo apresenta o referencial teórico sobre a Estratégia e o quarto capítulo sobre Controle e Custos. O quinto capítulo apresenta o Modelo CEC, discutindo suas especificidades para o ambiente em questão. O sexto capítulo apresenta a metodologia de Estudo de Caso, aplicada no Hospital São Lucas da PUCRS. O sétimo capítulo apresenta o estudo de caso, discutindo a aplicabilidade do modelo ao novo contexto. O estudo conclui que o hospital, em um momento de afirmação das estratégias de liderança em custos e configuração organizacional de defensor, tem reforçad
This dissertation intends to verify the applicability of the referent advanced model of Strategical Control of Costs (SCC) (Diehl, 2004) in the context of a philanthropic university hospital. The first chapter contextualizes the theme and the strategical control of the cost problems in this environment. The second chapter presents the hospital service scene in Brazil focusing upon philanthropic university hospitals. The third chapter shows the theory about strategy and the fourth one includes control and costs. The fifth chapter specifies the SCC Model according to the mentioned environment. The sixth chapter presents the Study of Case methodology applied to PUCRS St. Lucas Hospital. In the seventh chapter the Study of Case sets up the discussion of the model applicability in relation to the new context. At last, the study concludes that the hospital is in an affirmation moment of the leadership strategies in relation to the costs and oranizational configuration as a defender the hospital has reinforced the c
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Feng, Huiyun. "Expression and regulatory roles of the Caenorhabditis elegans homeobox C02F12.10 and CEH-19." Thesis, University of Leeds, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535680.
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Duarte, Sílvia Adelaide de Almeida Gonçalves Ramos. "A gestão de recursos humanos e o controlo de custos : o CEC-CCIC." Master's thesis, FEUC, 2011. http://hdl.handle.net/10316/17868.
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Relatório de estágio do mestrado em Gestão, apresentado à Faculdade de Economia da Universidade de Coimbra, sob a orientação de Mário Augusto e Paulo Caetano.O presente trabalho pretende ser o reflexo de um estágio curricular realizado no Conselho Empresarial do Centro/Câmara do Comércio e Indústria do Centro, uma associação sem fins lucrativos que representa as associações empresariais da região Centro. O estágio insere-se no Mestrado em Gestão da Faculdade de Economia da Universidade de Coimbra tendo decorrido entre Fevereiro e Julho de 2011. Procedeu-se, em primeiro lugar, à caracterização da organização, à exposição das suas actividades principais e à sua contextualização no meio envolvente. Posteriormente, efectuou-se uma descrição das actividades desenvolvidas consideradas mais relevantes, as quais consistiram na criação e aplicação de um mapa de controlo de pessoal e na concepção de um sistema de custeio baseado nas actividades (ABC) aplicado a um serviço prestado pela organização (emissão de Certificados de Origem). Por fim, procedeu-se à análise das actividades desenvolvidas no decorrer do estágio, evidenciando os resultados alcançados e as principais dificuldades verificadas.
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Kaltea, Eddie, and Daniel Lundgren. "Utveckling och konstruktion av analysatorverktyg för styrsignaler i HDMI-gränssnittet." Thesis, Linköping University, Linköping University, Computer Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16789.
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Utveckling av produkter som skall stöda HDMI-standarden medför många hinder som behöver överkommas. Ett av problemen är certifiering mot standarden. Det är svårt att testa att standardens alla krav uppfylls på ett utvecklingsföretag då testutrustningen är kostsam och därför ej tillgänglig. Ett enkelt verktyg har därför utvecklats för att underlätta testning av att standarden följs.
Denna rapport inleds med en problemställning och grundläggande teori om relaterade ämnen. En förstudie följer sedan där olika sätt att lösa problemet presenteras. Sedan följer en övergripande beskrivning om hur verktyget fungerar och hur det tillverkades. I slutet på rapporten finns en efterstudie och resultat som beskriver hur verktygets utveckling har fungerat och hur resultatet från förstudien påverkat utvecklingen.
Resultatet av examensarbetet är en prototyp som går att använda för att underlätta testning av att HDMI-standarden följs i vissa avseenden.
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Silva, Junior Raimundo Lima da. "Implicações do polimorfismo genético de cyp1a1, gstm1 e gstt1 na suscetibilidade do carcinoma espinocelular da laringe." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tede/6205.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
The larynx is a tubular organ of the aerodigestive tract whose main function is the production of voice, in addition to tasks related to the protection of the lower airways and swallowing food. The squamous cell carcinoma presents itself as a multifactorial disease and epigenetic being influenced by environmental factors, behavioural and relate to the individual. Several polymorphic genes that encode enzymes involved in the biotransformation of the carcinogens have been associated to the development of cancer, especially in squamous cell carcinoma of head and neck. The CYP1A1m, GSTM1 and GSTT1 genes which catalyzes the oxidation of PAHs in phenolic and epoxides products. The purpose of this study was to evaluate the epidemiological data of patients diagnosed with squamous cell carcinoma of the larynx from the Cancer Registry of Population basis of Goiânia and from Association of Cancer Combat in Goiânia, analyzing data from 63 medical records followed in a period of 6 year; establish the allelic profiles of the gene CYP1A1m, GSTM1 and GSTT1 in casecontrol groups investigating the degrees of suscetibility of patients diagnosed with squamous cell carcinoma (SCC) of the larynx, according to smoking and alcoholism habits. In total 112 samples were evaluated, 63 from patients with SCC of the larynx and 49 patients in the control group. The CEC of the larynx was about 3,5 times more frequent in men than in women. The rate of survival on general was approximately 66% to 6 years. The smoking and ethilic habits associated have a significantly lower survival. No significant differences were found in the staging analysis and treatment of patients. Were found allelic frequencies of CYP1A1m1 of 52,4% (34/62) and 63,3% (31/49) for the wild allele T and 44,4% (28/62) and 34,7% (18/49) for the mutant allele C. There were no statistically significant associations between allelic variants and genotypic CYP1A1m1 with squamous cell carcinoma of the larynx. Positive genotypic frequencies were observed for the genes GSTM1 and GSTT1 of 41.3% (26/63) and 54.0% (34/63) to the patients with laryngeal cancer, and 49,0% (24/49) and 51,0% (25/49) for the control group, respectively. For the assessment of genotype GSTM1 (null) and GSTT1 (null), the patients if the case group had 58,7% (37/63) and 46,0% (29/63) of genotypes for GSTM1 null and GSTT1, while the patients in the control group showed 51,0% (25/49) and 40,8% (20/49). There was no statistically significance in associations of genotypic variants GSTM1 (null) and GSTT1 (null) with the larynx squamous cell carcinoma. In this context, an experimental study was accomplished in the intention of evaluating the function of the genes Cyp and Gst in the metabolism of the Cyclophosphamide. This study addressed the Cyclophosphamide toxicological evaluation and analysis of the polymorphism of Cyp2a29 and Gstp1 BALB/c genes in mice, correlating them with the toxicity of drugs through the assessment of organs commonly affected. It was determinated the DL50 of the 474mg/kg. Subsequently, another 40 mice were used on the assessment of the genetic polymorphism of genes Cyp2a29 and Gstp1. As for toxicity, cyclophosphamide caused reduction in body weight at different doses and kidneys, spleen, liver, heart and lungs. The animals that received a dose of 500mg/Kg died in 24 hours, three animals with a dose of 250mg/Kg died the end of one week. The evaluation of toxicity showed changes of varying degrees of congestion observed in the spleen, liver and heart. There were not found statistically significant differences between the frequencies of allelic and genotypic to Cyp2a29 and Gstp1 in groups of animals studied. This observation should be probably the characteristic line BALB/c are isogenic. Studies that make the use se of tests of genetic suscetibility, epidemic evaluation, combined to the evaluation anatomopathological they allow the study of the interaction genetic atmosphere and a possible standardization of various chemotherapy protocols for treatment.
A laringe é um órgão tubular do trato aerodigestivo cuja principal função é a produção da voz, além de funções relacionadas com a proteção das vias aéreas inferiores e deglutição alimentar. O carcinoma de células escamosas (CEC) de laringe apresenta-se como uma doença multifatorial e epigenética sendo influenciada por fatores ambientais, comportamentais e inerentes ao indivíduo. Vários genes polimórficos que codificam enzimas envolvidas na biotransformação de carcinógenos têm sido associados ao desenvolvimento de câncer, sobretudo no carcinoma espinocelular de cabeça e pescoço. Os genes CYP1A1m1, GSTM1 e GSTT1 são fundamentais no processo de detoxificação de Poli - Hidrocarbonetos Aromáticos (PHA) e de diversas moléculas endógenas, facilitando o seu metabolismo e excreção. Os objetivos do presente estudo foram de avaliar os dados epidemiológicos de pacientes diagnosticados com CEC da laringe do Registro de Câncer de Base Populacional de Goiânia (RCBP) da Associação de Combate ao Câncer em Goiás (ACCG), analisando os dados de 63 prontuários acompanhados num período de 6 anos; estabelecer os perfis alélicos dos genes CYP1A1m1, GSTM1 e GSTT1 em grupos caso-controle investigando os graus de suscetibilidade dos pacientes diagnosticados com CEC de laringe, segundo hábitos tabagistas e etilistas. Ao total foram avaliadas 112 amostras, sendo 63 provenientes de pacientes com CEC da laringe e 49 de pacientes do grupo controle. O CEC da laringe se mostrou cerca de 3,5 vezes mais freqüente em homens que em mulheres. A taxa de sobrevida relativa geral foi de aproximadamente 66% para 6 anos. Os hábitos tabagista e etilista concomitantes apresentam uma sobrevida consideravelmente menor. Foram encontradas freqüências alélicas para CYP1A1m1 de 52,4% (34/62) e 63,3% (31/49) para o alelo selvagem T e 44,4% (28/62) e 34,7% (18/49) para o alelo mutante C. Não foram encontradas associações estatisticamente significativas das variantes alélicas e genotípicas CYP1A1m1 para o CEC da laringe. Quanto aos genes GSTM1 e GSTT1 foram observadas freqüências genotípicas positivas para os genes GSTM1 e GSTT1 de 41,3% (26/63) e 54,0% (34/63) para os pacientes com carcinomas laríngeos, e de 49,0% (24/49) e 51,0% (25/49) para o grupo controle, respectivamente. Para a avaliação do genótipo GSTM1 (nulo) e GSTT1 (nulo), os pacientes do grupo caso apresentaram 58,7% (37/63) e 46,0% (29/63) de genótipos nulos para GSTM1 e GSTT1, enquanto que os pacientes do grupo controle apresentaram 51,0% (25/49) e 40,8% (20/49). Não foram encontradas associações estatisticamente significativas das variantes genotípicas GSTM1 (nulo) e GSTT1 (nulo) para o CEC da laringe. Neste contexto, foi realizado um estudo experimental no intuito de avaliar o papel dos genes Cyp e Gst no metabolismo da ciclofosfamida. Tal estudo abordou avaliações toxicológicas da Ciclofosfamida e a análise do polimorfismo dos genes Cyp2a29 e Gstp1 em camundongos BALB/c e correlacionando-os com a toxicidade da droga através da avaliação dos órgãos comumente afetados. A DL50 da droga observada em 40 camundongos foi de 474mg/Kg. Posteriormente, outros 40 camundongos foram utilizados na avaliação do polimorfismo genético dos genes Cyp2a29 e Gstp1. Quanto à toxicidade, a ciclofosfamida ocasionou redução da massa corporal nos rins, baço, fígado, coração e pulmões. A avaliação da toxicidade demonstrou alterações de diferentes graus de congestão observados no baço, fígado e coração. Não foram encontradas diferenças estatisticamente significativas entre as freqüências alélicas e genotípicas de Cyp2a29 e Gstp1 nos grupos dos animais estudados. Estudos que preconizem a utilização de testes toxicológicos combinados à avaliação anatomopatológica e investigação da variabilidade genética permitem a padronização de protocolos de tratamento de diversos quimioterápicos.
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SEGUIN, PHILIPPE. "Etude comparative de deux posologies d'aprotinine lors des reprises de chirurgie cardiaque sous cec." Rennes 1, 1992. http://www.theses.fr/1992REN1M026.
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Arantes, Haydêe Sant' Ana. "Memórias do cineclubismo: a trajetória do CEC - Centro de Estudos Cinematográficos de Juiz de Fora." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/434.
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Esta dissertação pretende investigar a trajetória do grupo de cineclubismo: CEC – Centro de Estudos Cinematográficos de Juiz de Fora - formado por jovens estudantes que atuou durante vinte anos (1957-1977) com iniciativas de caráter cultural, promovendo sessões de cinema, festivais e cursos de cinema na cidade. Nosso objetivo em estudar a memória desse grupo é compreendermos sua importância como um movimento cineclubista na história da cidade, quanto para percebermos o papel do cineclubismo enquanto “lugar de cultura” e de ressignificação do espaço público. E principalmente, ainda para entendermos o cinema como um instrumento gerador de sociabilidade, atuante na construção de relações sociais. Nossa metodologia apoia-se na técnica de entrevista em história oral, que serve como um meio para o resgate de memórias individuais e coletivas dos integrantes do CEC. Pensando nisso, foram realizadas 23 entrevistas com pessoas que participaram desse movimento. A dissertação fundamenta-se na perspectiva historiográfica como elemento chave para a reconstrução da trajetória do grupo.
This dissertation aims to investigate the film group trajectory: CEC – Center of Cinematography Studies of Juiz de Fora. It was formed by young scholars who served for twenty years (1957-1977) with cultural initiatives, promoting movie sessions, festivals and film courses in the city. Our goal in studying the memory of that group is understand its importance as a film society movement in the city history, how to realize the role of film as "place of culture" and of a new signification of public space. And mostly, it is still to understand film as an instrument of generator sociability, active in building social relationships. Our methodology is based on oral history interview technique, which serves as a means for the redemption of individual and collective members memories of the CEC. Then, we conducted 23 interviews with people who participated in this movement. The dissertation is based on the historiographical perspective as key element for rebuilding the group trajectory.
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Yip, Shu Yan. "Sensory organ assembly is governed by distal-less/Dlx homolog ceh-43 in caenorhabditis elegans /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202007%20YIP.
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Fernandes, Herc?lia Maria. "Cec?lia Meireles e a l?rica pedag?gica em Crian?a meu amor (1924)." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14289.
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Previous issue date: 2008-10-29The research Cec?lia Meireles and the Pedagogical Lyric in Children My Love (1924) consists in a critical analysis, a cultural and historical approach to the pedagogical intentionalities and to the social and educational functionalities expressed in the childish literary work of the poetess and educator Cec?lia Meireles (1901-1964), in Brazil, during the first decades of XX century. The author s conceptions of the literary art, the philosophical and educational foundations, the Christian and liberal ideologies and values pertinent to her work for children and the relations between her texts and the ideals of the Brazilian intellectuals to effect changes in the every day life based on the child formation and on the teaching feminization process were examined in the work. This paper shows a content analysis with the intention of offering signification to the work Children My Love (1924) according to the investigation of specific categories: child, motherhood and schooling; through the exploration of synonymous and bipolar key-words found in Cec?lia s documents: child/adult, teacher/mother; school/home, ignorance/intelligence. The research intends to understand how the author articulates, in her informal pedagogical action in Children s Literature, science, literary and Christian faith knowledge, in order to expand her social and educational ideal concentrated in children, guided by the maternal hand and aimed at constructing a New Man, New Civilization and a New Social Order
O trabalho de pesquisa Cec?lia Meireles e a L?rica Pedag?gica em Crian?a meu Amor (1924) consiste em uma an?lise cr?tica, numa abordagem hist?rico-cultural, das intencionalidades pedag?gicas e funcionalidades s?cio-educativas expressas na produ??o liter?ria infantil da poetisa e educadora Cec?lia Meireles (1901-1964), no Brasil, durante as primeiras d?cadas do s?culo XX. No trabalho examinam-se as concep??es de arte liter?ria da autora, fundamentos filos?fico-educacionais, valores e ideologias liberais crist?s pertinentes ? sua produ??o para crian?as e as rela??es de seus textos com os ideais dos intelectuais brasileiros para efetivar modifica??es no cotidiano a partir da forma??o da crian?a e do processo de feminiza??o do magist?rio. O estudo realiza uma an?lise de conte?dos, buscando oferecer significa??o ? obra Crian?a meu amor (1924) conforme a investiga??o de categorias espec?ficas: crian?a, maternidade e escolariza??o; por meio da explora??o de palavras-chave sin?nimas e bipolares identific?veis nos documentos de Cec?lia: crian?a/adulto, professora/m?e, escola/lar, ignor?ncia/intelig?ncia. A pesquisa busca compreender como a autora articula, em sua a??o pedag?gica n?o-formal na Literatura Infantil, os saberes da ci?ncia, da literatura e da f? crist?, a fim de expandir seu ide?rio s?cio-educacional centrado na crian?a, guiado pela m?o materna e voltado ? constru??o de um Novo Homem, Nova Civiliza??o e Nova Ordem Social
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Della, Iacono Christina. "Food Choice in Caenorhabditis elegans: Differences in a ceh-36 Mutant and Natural Hawaiian Isolate." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19290.
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By understanding the biological mechanisms of food choice—a behavior that strongly impacts the evolutionary fitness of animals, from worms to humans—we can begin to understand the biological underpinnings of decision making in general and use such knowledge to better understand how this faculty fails in addiction, mental illness, and other disorders. Here, we analyze food choice in Caenorhabditis elegans, a convenient, genetically tractable organism. We describe how prior experience with high and low quality foods alters future food choice in three strains (N2, ceh-36, HW). We also provide evidence that chemosensory neurons AWC are required for altering food choice after experience. Additionally, we gather support for the use of HW and N2 in quantitative trait locus mapping, a method that would allow us to identify genetic loci that contribute to the heritable variation in food choice.
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Berrios, Yana Sonia Sarita. "Aneis de funções continuas." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/306883.
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Orientador : Jorge Tulio Mujica AscuiDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica
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Mestrado
Mestre em Matemática
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Netz, Linda, and Elin Salmonsson. "Biomassa för rening av metallkontaminerat grundvatten : En undersökning av biomassamaterial i Uganda." Thesis, KTH, Industriell ekologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147900.
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Världen står inför ett stort vattenförsörjningsproblem som måste lösas – så många som 884 miljoner människor använder idag potentiellt förorenade vattenkällor till sitt dricksvatten. Denna rapport fokuserar på ett av de drabbade länderna som är Uganda. Syftet med projektet är att undersöka vilket/vilka av de fem olika ugandiska växterna; Erythrina abyssinica, Musa spp, Cyperus papyrus, Imperata cylindrica och Coffea canephora som är mest lämplig för rening av kadmium- och blykontaminerat grundvatten. Katjonbyteskapaciteten bestäms genom laboration. Analyser kring växtmaterialen görs med hjälp av litteraturstudier och intervjuer med en doktorand från Uganda. M. spp visar sig ha klart högst katjonbyteskapacitet och finns även i form av mycket avfall, därför anses denna vara det mest lämpliga materialet för rening. Lösningen skulle kunna implementeras i samhället med ett filter gjort av växtmaterial, om vidare forskning görs.The world is facing a major water supply problem to solve, as many as 884 million people currently use potentially polluted water sources for their drinking water. This report focuses on one of the affected countries, which is Uganda. The project aims to examine which of the five different Ugandan plants; Erythrina abyssinica, Musa spp, Cyperus papyrus, Imperata cylindrica and Coffea canephora that is the most suitable for purification of cadmium- and lead contaminated groundwater. The cation exchange capacity is determined by laboratory experiment. Literature studies and interviews with a Ugandan postgraduate student are used for the analysis of the plant materials. M. spp has the highest cation exchange capacity and contributes with a lot of waste material; therefore it is considered the most suitable material for purification. The solution could be implemented in the community with a filter made of plant material, if further research is done.
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Cabasse, Clémence. "Angiogénèse et CD146 dans les gammapathies monoclonales." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1B016.
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Le myélome multiple est une néoplasie plasmocytaire caractérisée par une prolifération clonale de plasmocytes malins au niveau de la moelle osseuse. Il correspond à environ 13% des cancers hématologiques et la survie médiane à 10 ans est d’environ 30%. Le CD146 est une molécule d’adhésion (CAM) qui est surtout exprimée au niveau des jonctions des cellules endothéliales. A l’origine, le CD146 a été identifié comme un marqueur tumoral du mélanome (MCAM) et, par la suite, il a été étudié dans de nombreux cancers tels que les cancers du rein, du sein, du poumon, les cancers gastriques et les ostéosarcomes. Son expression est le plus souvent associée à un mauvais pronostic. Nous avons montré pour la première fois, que cette molécule s’exprimait aussi à la surface des plasmocytes normaux, cette expression apparaissant tardivement au cours de la différenciation B. Nous avons montré que cette expression était modulée sur des plasmocytes tumoraux de gammapathie monoclonale avec une forte diminution voire le plus souvent une disparition sur les plasmocytes malins de Myélome Multiple (MM). De plus, nous avons montré que CD146 constituait un facteur de bon pronostic indépendant dans cette maladie et qu’il était un des mécanismes permettant à la cellule tumorale d’avoir un avantage en termes de survie. Un second axe de recherche a consisté à la mise en place d’une technique de détection des cellules endothéliales circulantes dans le sang et in situ dans la moelle osseuse dans le myélome multiple afin de disposer d’un outil permettant l’étude de l’angiogenèse dans cette pathologie ainsi que son suivi en cliniqueMultiple Myeloma is a neoplastic plasma-cell disorder that is characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment. It accounts for approximately 13% of hematologic cancer and the ten year survival rate is approximately 30%. CD 146 is an adhesion molecule (CAM) that is essentially expressed at endothelial junctions. At first, CD 146 was identified as a tumor marker of melanoma. It subsequently was studied in conjunction with cancer of the kidney, the breast, the lung, as well as gastric cancers and osteosarcomas. Its expression is most often associated with a bad prognosis. For the first time we have shown that this molecule is expressed at the surface of normal plasma cells, this expression appearing during the late stages of B cell differentiation. We have demonstrated that this expression was modulated on Multiple Myeloma (MM) plasma cells, and and was significantly decreased or disappeared in malignant plasma cells. Moreover, we have shown that CD146 was an independent good prognostic marker and that it was implicated in mechanisms that confers a survival advantage to the tumor cell. The next part of the project consisted to set up a detection protocol for circulating endothelial cells in blood and bone marrow in multiple myeloma in order to develop a tool for studying angiogenesis in this pathology which can also be used during therapeutic monitoring
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Neyra, Norbil Leodan Cordova. "Teorida de G-índice e grau de aplicações G-equivariantes." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-22062010-091958/.
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Antes da publicação do trabalho An ideal-valued cohomological index theory with applications to Borsuk-Ulam and Bourgin-Yang theorems\"de Fadell e Husseini [20], haviam sido apenas considerados índices numéricos de G-espaços, nos casos G =\'Z IND. 2\' e G um grupo finito. No entanto, tais índices numéricos são obviamente insuficientes no caso de grupos mais complexos, como por exemplo a 1-esfera \'S POT. 1\'. Neste contexto, Fadell e Husseini introduziram o chamado Indice cohomológico de valor ideal: a cada G-espaço X paracompacto, eles associaram um ideal \'Ind POT. G\' (X;K) do anel de cohomología H*(BG;K), onde a cohomologia de Cech H* é considerada com coeficientes em um corpo K e BG é o espaço classificante do grupo G. Além disso, Fadell e Husseini associaram a este ideal o Índice cohomológico de valor numérico, o qual é definido como sendo a dimensão do K-espaço vetorial obtido do quociente entre o anel H*(BG;K) e o ideal \'Ind POT. G\' (X;K). O objetivo principal deste trabalho é apresentar um estudo detalhado deste índice e utilizá-lo no estudo dos resultados sobre grau de aplicações G-equivariantes provados por Hara em \"The degree of equivariant maps\"[24]Before the appearance of the paper An ideal-valued cohomological index theory with applications to Borsuk-Ulam and Bourgin-Yang theorems\"of Fadell and Husseini [20], had been considered numerical indices of G-spaces, when G = \'Z IND. 2\' and when G is a finite group. However, such numerical indices are obviously insufficient in the case of groups more complexes, for example, G =\'S POT 1\'. In this context Fadell andHusseini, introduced the called valued-ideal cohomological index: to every paracompact G-space X they associated an ideal \'Ind POT. G\' (X,K) of the cohomology ring H*(BG;K), where the Cech cohomology H* is considered with coefficients in a field K and BG is the classifying space of the group G. Moreover, they associated to this ideal the numerical valued cohomological index, that is, the dimension of K-vector space obtained by the quotient between the ring H*(BG;K) and the ideal \'Ind POT. G\' (X,K). The main objective of this work is to present a detailed study of this index and use such index on the study of results on degree of equivariant maps proved by Hara in his paper The degree of equivariant maps\"[24]
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Elsayed, Mustafa Mohammed Abdelaziz Verfasser], Reinhard H. H. [Akademischer Betreuer] [Neubert, Gregor [Akademischer Betreuer] Cevc, and Alfred [Akademischer Betreuer] Blume. "Analytical approaches to physicochemical characterization of colloidal drug carriers / Mustafa Mohammed Abdelaziz Elsayed. Betreuer: Reinhard Neubert ; Gregor Cevc ; Alfred Blume." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://d-nb.info/1025202058/34.
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Araia, Sellyhom, and Betiel Werede. "Has EU membership lead to growth in the CEEC? : A study that examines the income convergence towards the EU-15." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-26567.
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The European Union was created to promote peace and stability and evolved to become an economic union. Its member states are part of trade agreements where tariffs and quotas are abolished. Trade liberations lead to easier access of information and technology which in turn lead to faster growth. This study was made as we were interested to see if high level of economic integration, EU membership, has effected economic growth. The dependent variable we chose to study is GDP growth per capita. The time period included in the study is the years 1996-2011. In this study we are interested to see if higher level of economic integration has led to growth and income convergence in the Central and Eastern European. A multiple regression analysis has been conducted to see if EU membership have an effect on growth. In addition a beta convergence regression is carried out in order to see if the new member states are catching up to the EU income level. We found that joining the EU has no significant effect on growth. However the CEEC seem to enjoy higher level of price stability due to EU membership. However due to the lack of observations the results we received are inconclusive.
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Owraghi, Melissa. "Functions of TBX-35, CEH-51, and TCF/POP-1 in mesoderm specification in Caenorhabditis elegans." Diss., [Riverside, Calif.] : University of California, Riverside, 2010. http://proquest.umi.com/pqdweb?index=0&did=2019822751&SrchMode=2&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1274113144&clientId=48051.
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Thesis (Ph. D.)--University of California, Riverside, 2010.Includes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed May 17, 2010). Includes bibliographical references. Also issued in print.
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Hindocha, Darsha. "The evaluation of capillary electrochromatography (CEC) for use within a regulated environment in the pharmaceutical industry." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399525.
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Silva, Nelson Antonio. "Uma versão parametrizada do teorema de Borsuk-Ulam." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-12042011-082846/.
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O teorema clássico de Borsuk-Ulam nos dá informações à respeito de aplicações \'S POT. n\' \'SETA\' \'R POT. n\', no qual \'S POT. n\' é um \'Z IND. 2\' -espaço livre. O teorema afirma que existe pelo menos uma órbita que é enviada em um único ponto em \'R POT. n\'. Dold [9] estendeu este problema para o contexto de fibrados, considerando aplicações f : S (E) \'SETA\' \'E POT. \'prime\'\' nos quais preservam fibras; aqui, S (E) denota o espaço total do fibrado em esfera sobre B associado ao fibrado vetorial E \'SETA\' B e \'E POT. \'prime\'\' \'SETA\' B é o outro fibrado vetorial. O objetivo desse trabalho é provar esta versão do teorema de Borsuk-Ulam obtida por Dold, chamada versão parametrizada do teorema de Borsuk-Ulam. Nós também provamos uma versão cohomológica deste problemaThe classical Borsuk-Ulam Theorem gives information about maps \'S POT. n\' \'ARROW\' \'R POT. n\' where \'S POT. n\' has a free action of the cyclic group \'Z IND. 2\'. The theorem states that there is at least one orbit which is sent to a single point in \'R POT. n\'. Dold [9] extended this problem to a fibre-wise setting, by considering maps f : S (E) \'ARROW\' \' E POT. prime\' which preserve fibres; here, S (E) denotes the total space of the sphere bundle associated over B to a vector bundle E \'ARROW\' B and \'E POT. prime\' \'ARROW\' B is other vector bundle over B. The purpose of this work is to prove this version of the Borsuk-Ulam theorem obtained by A. Dold, called parametrized version of the Borsuk-Ulam theorem. We also prove a cohomological generalization of this problem
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Schlierkamp, Thorben [Verfasser], Jochen [Akademischer Betreuer] Wengenroth, Jochen [Gutachter] Wengenroth, and Leonhard [Gutachter] Frerick. "De Rham and Cech-de Rham Cohomologies of Smooth Foliated Manifolds / Thorben Schlierkamp ; Gutachter: Jochen Wengenroth, Leonhard Frerick ; Betreuer: Jochen Wengenroth." Trier : Universität Trier, 2021. http://d-nb.info/1238896499/34.
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Lusk, Mandy E. "Teachers of Students with Emotional and Behavioral Disorders’ Perceptions of Professional Standards of Practice." Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc149634/.
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In recent decades, there has been renewed interest in examining the effectiveness of teacher preparation programs. Unfortunately, researchers have found that there is limited empirical research on the effectiveness of quality special education teacher preparation programs, specifically those programs specializing in the education of students with emotional and behavioral disorders (EBD). The Council for Exceptional Children (CEC), the largest special education organization, conducts research on the standards needed by teachers who serve children and youth with exceptionalities. These CEC standards are recommended to serve as a guide for teacher preparation programs in special education. Utilizing the CEC standards delineated for preparation programs in EBD, the present study sought to determine how graduates of one program perceived the importance of the standards and their perceived proficiency in using the standards in their work with students with EBD. Results indicated that graduates viewed the standards as Important to their work with students with EBD. Further, they viewed their proficiency in using the standards to be above average. In addition, the present study examined the relationship between graduates perceived importance and perceived proficiency in using the CEC standards. Results indicated that graduates who had higher score ratings on their perceived importance of the standards tended to have higher ratings on their perceived proficiency scores.
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Oliveira, Schariza Pacheco Berny de. "Conex?es liter?rias da vida urbana : cidade e sujeito em Cec?lia Giannetti e Paloma Vidal." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/1983.
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Previous issue date: 2011-01-07Esta disserta??o apresenta a an?lise da rela??o identit?ria, manifestada na cria??o liter?ria, estabelecida entre sujeito urbano e cidade, com especial aten??o ? escrita feminina contempor?nea. ? luz do aporte te?rico composto por Roland Barthes, Walter Benjamin, Beatriz Resende, Kevin Lynch, Giulio Argan, Renato Cordeiro Gomes, Heloisa Buarque de Hollanda, James Hillman, entre outros, procurou-se verificar reflexos e influ?ncias do ambiente urbano no mundo interior do indiv?duo, sobretudo no que diz respeito ? busca pessoal de identifica??o com o lugar no qual se vive. O corpus liter?rio ? formado pelos romances intitulados Lugares que n?o conhe?o, pessoas que nunca vi, de Cec?lia Giannetti e Algum Lugar, de Paloma Vidal. O principal aspecto de an?lise e reflex?o, na primeira obra, ? a consequ?ncia traum?tica da viol?ncia urbana imprimida na protagonista. Em rela??o ? segunda narrativa, ser? destacada a procura pessoal da personagem por uma correspond?ncia afetiva e o estabelecimento de uma sensa??o de conforto frente ao lugar no qual est? vivendo ou visitando. Sob essa perspectiva, ser? observada a rela??o entre identidade velada das protagonistas e suas trajet?rias no cotidiano citadino. Da mesma forma, o estudo pretende evidenciar a rela??o entre as cidades liter?rias apresentadas Rio de Janeiro, Buenos Aires e Los Angeles e as cidades correspondentes no mundo real e concreto, destacando a exist?ncia desse di?logo por meio da aproxima??o da cidade no texto com a cidade conhecida por escritores e leitores.
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Borges, Filho Francisco Pereira. "ANÁLISE DO POLIMORFISMO GENÉTICO DO CÓDON 72 DO GENE P53 EM PACIENTES COM CARCINOMA ESCAMOSO DE BASE DA LÍNGUA." Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/2334.
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Previous issue date: 2009-05-05INTRODUCTION: The polymorphism at codon 72, proline (p53P) or arginine (p53R) is involved in the ability of p53 to interact with cellular proteins. Several authors have shown that the presence of genotype p53RR confers greater risk of developing tumors. OBJETIVE: To assess the allelic frequency of genetic polymorphism in codon 72 in TP53 gene in samples obtained from patients diagnosed with squamous carcinoma of base of the tongue treated at the Hospital Araújo Jorge and Associação de Combate ao Câncer em Goiás (ACCG)between 1990 and 2006. Evaluate the genetic predisposition for Base of Tongue Cancer linked of TP53 polimorphism, by identififyin of the presence or absence of the alleles p53R and/or p53P alleles in patients with this pathology. MATERIALS AND METHODS: This study is a casecontrol retrospective in nature, was conducted at Núcleo de Pesquisas Replicon of the Universidade Católica de Goiás in conjunction with the Hospital Araújo Jorge. We evaluated 54 patients with squamous carcinoma of the base of the tongue and 186 individuals without cancer. These were matched regarding gender, age, and the group of cases was evaluated clinical stage and smoking, alcohol consumption. The genotypes p53R and p53P were determined by PCR, using specific primers. RESULTS: The allele frequencies for p53R in cases and controls were 75.9% and 74.2%, while the p53P were 24.1% and 25.8% respectively. There was no statistically significant difference (p = 0.79) in allele frequencies between the two groups, suggesting that the polymorphism of codon 72 of TP53 is not a risk factor for susceptibility to squamous cell carcinoma of the tongue base. CONCLUSION: The study does not find relationship between p53R and CCO carcinogenesis when compared sex, age and color.
INTRODUÇÃO: O polimorfismo no códon 72, prolina (p53P) ou arginina (p53R) está envolvido na habilidade da p53 em interagir com as proteínas celulares. Vários autores têm demonstrado que a presença do genótipo p53RR confere maior risco de desenvolvimento de tumores. OBJETIVO: Avaliar a freqüência alélica do polimorfismo genético no códon 72 do gene p53 em amostras obtidas de pacientes diagnosticados com Carcinoma Escamoso de Base de Língua atendidos no Hospital Araújo Jorge, da Associação de Combate ao Câncer em Goiás (ACCG), entre os anos de 1999 e 2006. Avaliar a predisposição genética do câncer de base da língua relacionada ao polimorfismo de TP53, através da identificação da presença ou não dos alelos p53R e/ou p53P nos pacientes com esta patologia. MATERIAIS E METODOS: O presente estudo é do tipo caso-controle de caráter retrospectivo, foi realizado no Núcleo de Pesquisas Replicon da Universidade Católica de Goiás em conjunto com o Hospital Araújo Jorge. Foram avaliados 54 pacientes com carcinoma escamoso de base da língua e em 186 indivíduos sem câncer. Estes foram pareados quanto ao sexo, idade e no grupo caso, foram avaliados o estádio clínico e hábitos de etilismo e tabagismo. A genotipagem dos alelos p53R e p53P foi determinada por PCR, utilizando-se primers específicos. RESULTADOS: As freqüências alélicas para p53R nos casos e controles foram de 75,9% e 74,2%, enquanto que de p53P foram de 24,1% e 25,8%, respectivamente. Não houve diferença estatisticamente significativa (p = 0,79) nas freqüências alélicas entre os dois grupos analisados, sugerindo que o polimorfismo do códon 72 de TP53 não seja um fator de risco de susceptibilidade ao carcinoma escamoso de base da língua. CONCLUSÃO: Não foi observada associação entre a variante p53R e o desenvolvimento da carcinogênese de CCO de base da língua, segundo o sexo, idade e etnia.
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Nxumalo, Mbekezeli Sibahle. "Ultrafilters and Compactification." UWC, 2020. http://hdl.handle.net/11394/7374.
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>Magister Scientiae - MScIn this thesis, we construct the ultrafilter space of a topological space using ultrafilters as points, study some of its properties and describe a method of generating compactifications through the ultrafilter space. As part of investigating some properties of the ultrafilter space, we show that the ultrafilter space forms a monad in the category of topological spaces. Furthermore, we show that rendering the ultrafilter space suitably separated results in a generation of separated compactifications which coincide with some well-known compactifications. When the ultrafilter space is rendered T0 or sober, the resulting compactifications is a stable Compactifications. Rendering the ultrafilter space T2 or Tychono results in the Stone_ Cechcompactification
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Bajpai, Saurabh. "ROLE OF HEPATIC CHOLESTEROL ESTER HYDROLASE (CEH) IN HYDROLYZING CHOLESTEROL ESTERS (CE) DELIVERED VIA SR-BI (SCAVENGER RECEPTOR CLASS B TYPE I) AND SR-BII." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1711.
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Reduction of cholesterol ester (CE) from lipid burden lesion-associated macrophage foam cells has been shown to reduce plaque volumes. Hydrolysis of CE to free cholesterol (FC) in macrophages is an essential step for removal of CE from the macrophage and its transport to the liver by high density lipoprotein (HDL) for further metabolism. Since CE must again be hydrolyzed into FC in the liver catalyzing this hydrolysis, it becomes imperative to find the identity of these enzymes. In this study the role of key enzyme in catalyzing the hydrolysis of CE to FC, neutral cholesterol ester hydrolase (CEH) was evaluated. Further, ability of this CEH to hydrolyze CE delivered via scavenger receptor BI (SR-BI) or SR-BII was also monitored. CE hydrolysis and FC efflux were monitored from cells transfected with CEH expression vector. No significant difference was noted in either the intracellular CEH activity or FC efflux between cells transfected with an empty vector or a CEH expression vector. Further no difference was seen when experiments were repeated with cells stably transfected with SR-BI or SR-BII. Future experiments with more optimization of the cells system used will be required to reach any conclusions on the role of CEH in hydrolyzing HDL-CE delivered via SR-BI/BII.