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Dissertations / Theses on the topic 'Cel Hypoxia'

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Published: 4 June 2021

Last updated: 27 July 2025

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1

Ljungkvist, Anna. "Imaging the tumor microenvironment : the dynamics and modification of hypoxia." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106.

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2

Lawrentschuk, Nathan Leo. "Hypoxia and angiogenesis in renal cell carcinoma." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/6790.

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Hypoxia is one of the hallmarks of cancer. It was first postulated to occur in solid tumours by Thomlinson and Gray in 1955.1 The presence of hypoxia has been demonstrated in different types of solid tumours.2 Intratumoral hypoxia is caused by the lack of functional blood vessels in proliferating tumour tissue, resulting in low intratumoral oxygen concentrations. If hypoxia is severe or prolonged, cell death occurs.3 Malignant cells can undergo genetic and adaptive changes that allow them to escape from dying of oxygen deprivation. These changes are associated with a more aggressive malignant

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3

Lester, Robin D. "Hypoxia activated cell signaling receptors in cancer." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3297526.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed April 28, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 114-134).

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4

Schioppa, Tiziana. "Effects of tumour hypoxia on cell migration." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434200.

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Cell adaptation to hypoxia requires activation of transcriptional programs that coordinate expression of genes involved in oxygen delivery (via- angiogenesis) and metabolic adaptation (via glycolisis). During migration and invasion of normal and pathological tissues, cells may encounter different oxygen levels, due to poor or altered vascularization, and recent evidence has suggested that chemotaxis is a cell function which may be affected by oxygen availability. This thesis describes how oxygen avaibility is a determinant parameter in the setting of chemotactic responsiveness to Stromal-Deriv

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5

Ledaki, Ioanna I. "Heterogeneity of tumour response to hypoxia : carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:757a8e79-b20d-496c-b69b-4d6a3b7b56e3.

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Carbonic anhydrase IX (CA9) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. The function of CAIX is to catalyze the reversible hydration of CO2 to bicarbonate and a proton. This helps hypoxic tumours to maintain a more neutral intracellular pH (pH<sub>i</sub>) promoting survival, but produces a more acidic extracellular (pH<sub>e</sub>) which promotes invasion and metastasis. Recent evidence has expanded on the role of hypoxia and CAIX by relating them to stem cell niches. In this study, taking advantage of the transmembrane location

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6

Nilsson, Ingrid. "Hypoxia, PDGF and VEGF in Vascular Development." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6894.

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7

Bedessem, Baptiste. "Contributions à l'étude de la réponse moléculaire à l'hypoxie : Modélisation mathématique et expérimentations sur cellules FUCCI." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAS024/document.

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Les effets biologiques de l'hypoxie sont très étudiés aujourd'hui, principalement en raison du rôle crucial que jouent les conditions d'oxygénation dans le développement des cancers.Depuis plusieurs années, une littérature foisonnante tente ainsi de décrire les multiples aspects de la réponse moléculaire, cellulaire et physiologique à l'hypoxie. La complexité des voies de signalisation impliquées et la diversité de leurs effets cellulaires rendent la tâche délicate. Cet état de fait se reflète dans la pluralité des méthodes utilisées, depuis les simulations numériques jusqu'aux approches expér

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8

Lidgren, Anders. "Hypoxia inducible factor-1α in renal cell carcinoma". Doctoral thesis, Umeå universitet, Kirurgisk och perioperativ vetenskap, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1462.

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Hypoxia Inducible Factor-1α in Renal Cell Carcinoma Departments of Surgical and Perioperative Sciences, Urology and Andrology; Radiation Sciences, Oncology; Medical Biosciences, Pathology; and Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all human cancers. A distinguished feature of RCC is vascularisation and among the three dominating RCC types conventional RCC (cRCC) generally is more vascularised than papillary RCC (pRCC) and chromophobe RCC (chRCC). Angiogenesis is a critical step in tumour

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9

Milani, Manuela. "Cell stress response and hypoxia in breast cancer." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:74d3bf91-9888-4e9e-b5e1-7d5d2d476174.

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During severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting in the accumulation of unfolded proteins with consequent endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) and autophagy, a process involved in the physiological turnover of cytoplasmic components. The link between the UPR and autophagy is not clearly defined. The aim of this thesis is to investigate the role of the induction of UPR under severe hypoxia in tumour survival and resistance to therapy. The results of this research suggest that the activating tr

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10

Ibegbu, Augustine. "The effects of hypoxia on neuronal cell signalling." Thesis, Queen Margaret University, 2009. https://eresearch.qmu.ac.uk/handle/20.500.12289/7367.

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Hypoxia adversely affects cells and tissues, and neuronal cells in particular have been shown to be more susceptible to the injurious effects of hypoxia i.e. they may begin to die when oxygen supply is reduced or completely eliminated. Cannabinoid (CB1) receptor and opioid (μ, δ and κ) receptor agonists have been shown to elicit several central nervous system (CNS) effects, mediated via G protein-coupled receptors. The aim of the research presented in this thesis was to study the effect of hypoxia on neuronal cell signalling and the consequent neuroprotectant effects of cannabinoid and opioid

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11

Del, Sole Marianna <1981&gt. "Effect of hypoxia and hyperglycemia on cell bioenergetics." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4732/1/Del_Sole_Marianna_tesi.pdf.

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Mitochondria have a central role in energy supply in cells, ROS production and apoptosis and have been implicated in several human disease and mitochondrial dysfunctions in hypoxia have been related with disorders like Type II Diabetes, Alzheimer Disease, inflammation, cancer and ischemia/reperfusion in heart. When oxygen availability becomes limiting in cells, mitochondrial functions are modulated to allow biologic adaptation. Cells exposed to a reduced oxygen concentration readily respond by adaptive mechanisms to maintain the physiological ATP/ADP ratio, essential for their functions and s

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12

Del, Sole Marianna <1981&gt. "Effect of hypoxia and hyperglycemia on cell bioenergetics." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4732/.

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Mitochondria have a central role in energy supply in cells, ROS production and apoptosis and have been implicated in several human disease and mitochondrial dysfunctions in hypoxia have been related with disorders like Type II Diabetes, Alzheimer Disease, inflammation, cancer and ischemia/reperfusion in heart. When oxygen availability becomes limiting in cells, mitochondrial functions are modulated to allow biologic adaptation. Cells exposed to a reduced oxygen concentration readily respond by adaptive mechanisms to maintain the physiological ATP/ADP ratio, essential for their functions and s

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13

Webster, Lynne. "Hypoxia and proliferation in murine tumour models." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336415.

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14

Englund, Marita. "Effects of hypoxia and antiepileptic drugs on electrophysiological properties of CA1 neurons in hippocampus /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-237-8/.

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15

Wilcock, Paul. "A systems biology approach for investigating oral squamous cell carcinoma (OSCC)." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/a-systems-biology-approach-for-investigating-oral-squamous-cell-carcinoma-oscc(8ec3728b-1928-450f-b467-76996fa970fb).html.

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A systems biology approach was adopted in order to assess various aspects of the disease oral squamous cell carcinoma. Three main aims were addressed; assess the ability of CoCl2 to mimic the hypoxic response in a eukaryotic cell line, assess the role of PDE4D in oral squamous cell carcinoma (OSCC) and the construction of a normoxic/hypoxic mathematical model to identify therapeutic targets.Cancer cells often acquire a revised metabolism which aids in initiation, survival and progression of the tumour. This is predominantly due to the transcription factor HIF-1 which is activated under hypoxic

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16

Chen, Yixuan. "Effect of hypoxia on dendritic cell function and differentiation." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426446.

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17

Salvadore, Christopher P. "Brain cell injury: metabolic dysfunction in ischemia and hypoxia." Thesis, Boston University, 1988. https://hdl.handle.net/2144/38099.

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Thesis (M.A.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>A sequence of biochemical events responsible for the destruction of brain cells during oxygen deprivation has been proposed based on available experimental evidence reviewed in the text. Oxygen deficiency resu

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18

McAleer, James Joseph Anthony. "The hypoxic tumour cell : a therapeutic challenge." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317447.

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19

Sandlund, Johanna. "Angiogenesis in human renal cell carcinoma : hypoxia, vascularity and prognosis." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1331.

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20

Heddleston, John Michael. "The Role of Hypoxia in Modulating Glioma Cell Tumorigenic Potential." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1310043767.

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21

ZONCA, SARA. "Mechanisms driving response to hypoxia in MPM derived cell lines." Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/86961.

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22

Wilson, William J. "Hypoxia inducible factor 1a : molecular mechanisms of regulation /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-223-X.

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23

Davis, Brandon James. "VEGF signaling mechanisms in increased blood brain barrier permeability following hypoxia." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261273.

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24

Givelet, Maëlle. "Étude des cellules souches germinales : caractérisation des cellules souches germinales humaines et effets de l'hypoxie Transcriptional landscape of spermatogonial stem cells and progenitors in human spermatogenesis Impact of hypoxia on the proliferation and colony-formation capacity of SSCs in culture Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB038.

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Tout au long de la vie, les spermatozoïdes sont produits dans le testicule à partir des cellules souches germinales (CSGs), au cours du processus de spermatogenèse. Les CSGs ont la capacité de s'auto-renouveler pour maintenir le stock de cellules souches et d'entrer en différenciation. L'infertilité masculine est responsable dans un cas sur deux des difficultés à enfanter au sein du couple. Chez les patients traités par radiothérapie et/ou chimiothérapie (plus particulièrement chez les enfants atteints de cancer), un des effets secondaires majeurs qui altèrent la qualité de vie après guérison

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25

Bhatia, Maneet. "Inhibition of the Thioredoxin System: Regulation by the Cancer Cell Environment." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367262.

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The oxygen environment in tumors is not static and involves constant cycling between hypoxic and re-oxygenation phases, a phenomenon known as intermittent hypoxia. Hypoxic and redox pathways are upregulated in response to intermittent hypoxia. The thioredoxin system, comprised of thioredoxin and thioredoxin reductase, is one of the main antioxidant systems, while hypoxia inducible factor 1 (HIF1) is the major hypoxia responsive system. High levels of both the thioredoxin system proteins and HIF1α have been correlated with extremely aggressive and highly metastatic tumors. Both these systems ha

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26

Hernandez, Ivan. "PRIMING CARDIOVASCULAR STEM CELLS FOR TRANSPLANTATION USING SHORT-TERM HYPOXIA." CSUSB ScholarWorks, 2016. https://scholarworks.lib.csusb.edu/etd/348.

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Conventional medical treatments fail to address the underlying problems associated with the damage inflicted by a coronary event. Thus, the long-term prognosis of patients admitted for heart failure is disheartening, with reported survival rates of 25 percent. Recent advances in stem cell research highlight the potential benefits of autologous stem cell transplantation for stimulating repair in heart tissue. However, a majority of those suffering from cardiovascular diseases are older adults whose autologous cells no longer possess optimum functional capacity. Additional work is needed to iden

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27

Noman, Muhammad zaeem. "Influence of hypoxia on tumour cell susceptibility to cytotoxic T lymphocyte mediated lysis." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T051/document.

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L’hypoxie est une caractéristique commune des tumeurs solides et l’une des spécificités du micro environnement tumoral. L’hypoxie tumorale joue un rôle important dans l’angio génèse, la progression maligne, le développement de métastases, la chimio/radio-résistance et favorise l’échappement au système immunitaire du fait de l’émergence de variant tumoraux avec un potentiel de survie et de résistance à l’apoptose augmenté. Cependant, très peu de travaux ont étudié l’impact de l’hypoxie tumorale sur la régulation de la susceptibilité des tumeurs à la lyse induite par la réponse immune cytotoxiqu

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28

Kukucka, Mark A. "Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/38407.

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The 1980's heralded the discovery and identification of extra-pituitary sources of the neurohypophysial hormone oxytocin in non-neural tissues of several animal species. The presence, location and biosynthesis of significant amounts of oxytocin in the ovarian corpus luteum was followed by the immunocytochemical demonstration of an oxytocin-like peptide in the testicular interstitial cells. Leydig cells, which comprise up to 80% of the testicular intertubular cell population, are known to synthesize testosterone in situ. Indirect evidence indicated that an oxytocin-like peptide was also present

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29

Kukucka, Mark Anthony. "Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro /." This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-170416/.

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30

Guimbellot, Jennifer S. "Role of hypoxia in epithelial gene regulation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/guimbellot.pdf.

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31

Schmidt, Dirk. "Role of JunB in hypoxia-mediated cell response and tumour angiogenesis." [S.l.] : [s.n.], 2001. http://www.freidok.uni-freiburg.de/volltexte/327.

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32

Peurala, E. (Emmi). "Regulators of hypoxia response and the cell cycle in breast cancer." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526202709.

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Abstract Breast cancer is the most common cancer affecting the female population of the Western world. It is a heterogeneous disease entity that encompasses tumors with remarkably different forms of behaviour, and it is therefore vital to distinguish patients with good and poor prognoses. The classical prognostic and predictive factors for breast cancer serve as tools for clinical oncologists when planning treatment, but the growing awareness of breast cancer biology is bringing about a need for novel prognostic and predictive biomarkers. This thesis examines the prognostic significance of hyp

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33

Chiarotto, James Anthony. "Hypoxia-induced upregulation of VEGF mRNA in cervical cancer cell lines." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0010/MQ40781.pdf.

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34

Ahmed, A. "Regulation of p53-dependent cell death responses in normoxia and hypoxia." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1298195/.

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Hypoxia, defined as low oxygen tension, is a common characteristic of growing tumours. Tumour cells adapt to their hypoxic microenvironment by inducing angiogenesis and escaping cell death. In doing so, tumour cells become resistant to radiotherapy and many forms of chemotherapy. Hypoxia signalling and angiogenesis is mediated by the hypoxia-inducible factor (HIF) transcriptional complex. HIF can crosstalk to the p53 tumour suppressor protein, a critical regulator of cell cycle and cell death responses to stress. This study aims to understand how cell death responses are regulated in tumour ce

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35

Pike, Luke R. G. "The role of ATF4 in hypoxia-induced cell death in cancer." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:f32e03f9-0bd2-4dd1-8320-b082b9b2d363.

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Cancer cells survive the harsh oxygen and nutrient deprivation of the tumour microenvironment through the selection of apoptosis-resistant and glycolytic clones (Cairns et al., 2011; Graeber et al., 1996). In particular, the integrated stress response (ISR) has been shown to be pivotal in cancer cell survival in vivo and the resistance of cancer cells to therapy (Harding et al., 2003). In recent years, it has become apparent that increased autophagy is one mechanism by which the ISR can confer resistance to stress (Kroemer et al., 2010). ATF4 is a major transcriptional effector of the integrat

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36

Anderson, Scott James. "Beta-cell dedifferentiation following short term hypoxia and clinical islet transplantation." Thesis, University of Newcastle upon Tyne, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.750387.

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Individuals with insulin-requiring type 1 diabetes account for around 10% of all diabetes cases in the UK. Administration of exogenous insulin to maintain blood glucose homeostasis can lead to life-threatening hypoglycaemia in a subset of people with type 1 diabetes, who have lost hypoglycaemic awareness. Islet transplantation is a life-saving therapy for these individuals who suffer recurrent, hospital requiring, episodes of hypoglycaemia. Despite improving outcomes, mainly due to an improved immunosuppression regimen, the functional duration of islet transplants still fails to match the gold

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37

Emery, Elizabeth Dorothy. "Regulation of stem cell marker LGR5 by hypoxia in colorectal cancer." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682727.

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Leucine rich repeat containing G-protein coupled receptor 5 (LGR5) is a well-established stem cell marker in the normal intestine. Recent evidence suggests LGR5 is also a marker of cancer stem cells in colorectal tumours. Cancer stem cells propagate and maintain tumours and are hypothesized to be refractory to therapy. Solid tumours frequently experience hypoxia and an unresolved question remains as to how the cancer stem cell population survives this environmental stress. Several regulatory links are known to exist between hypoxic and stem cell signalling pathways. However, the role of hypoxi

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38

Wangpaichitr, Medhi. "The Relevance of mTOR and Hypoxia Inducible Factor to 2-Deoxy-D-Glucose Toxicity in Lung Cancer Cell Lines Under Hypoxia." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/156.

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Hypoxic regions found in most solid tumors often contain cells which are resistant to various cancer therapies. However, hypoxia also forces cells to rely solely on the catabolism of glucose through glycolysis for ATP production and survival, thereby creating a therapeutic window that can be exploited by glycolytic inhibitors, such as 2-deoxy-D-glucose (2-DG). Previous studies in our lab demonstrated that activation of Hypoxia Inducible Factor (HIF-1) in hypoxic tumor cells confers resistance to glycolytic inhibition by 2-DG. In surveying a number of tumor types for differences in intrinsic

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39

Bhogal, Ricky Harminder. "The role of oxidative stress and CD154-mediated reactive oxygen species in regulating hepatocyte cell death during hypoxia and hypoxia-reoxygenation." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3857/.

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Hypoxia and hypoxia-reoxygenation (H-R) are pathogenic factors in many liver diseases and lead to hepatocyte death as a result of reactive oxygen species (ROS) accumulation. Activation of the Tumour Necrosis Factor-a (TNFa) super-family member CD40 by its cognate ligand CD 154 can induce hepatocyte apoptosis via induction of autocrine/paracrine F as Ligand/CD178 expression but the relationship between CD40 activation, ROS generation and hepatocyte cell death is poorly understood. Therefore, human hepatocytes were isolated from liver tissue and exposed to an in vitro model of hypoxia and H-R in

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40

Swinson, Daniel. "Hypoxic markers in non-small cell lung cancer." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29476.

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Hypoxia is an important factor in the pathogenesis of solid tumours. Hypoxia inducible factors (HIF)-1alpha and HIF-2alpha are transcription factors that in part mediate the cellular response to hypoxia. These transcription factors are involved in the regulation of angiogenesis, anaerobic metabolism, pH homeostasis, erythropoiesis and cell death.;Immunohistochemical (IHC) assays were optimised for HIF-1alpha and one of its transcriptional targets, Carbonic Anhydrase (CA) IX. Attempts to optimise an IHC assay for HIF-2alpha failed to produce reproducible staining. A scoring system was also devi

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Charlier, Nico Nawid. "Hypoxie-induzierter Zelltod und Veränderungen der HIF-1-Aktivität in PC12-Zellen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15012.

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Der Transkriptionsfaktor hypoxia inducible factor-1 (HIF-1) trägt zur Expression von adaptiven Genen unter hypoxischen Bedingungen bei. Zusätzlich wurde vermutet, dass HIF-1 eine Rolle in der Regulation des späten neuronalen Zelltodes spielt. Suspensionszellen und adhärenten PC12-Zellen mit Nervenwachstumsfaktor (NGF) behandelt, wurden als ein experimentelles Modell für die Untersuchung der Beziehung zwischen Hypoxie induziertem Zelltod und Aktivität von HIF-1 herangezogen. Zelltod wurde durchflusszytometrisch mit einer Doppelfärbung (Annexin V und Propidium-Jodid) der Zellen und durch eine An

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42

Pan, Minglin, Ying Han, Rui Si, Rui Guo, Ankit Desai, and Ayako Makino. "Hypoxia-induced pulmonary hypertension in type 2 diabetic mice." SAGE PUBLICATIONS INC, 2017. http://hdl.handle.net/10150/623894.

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Hypoxia-induced pulmonary hypertension (HPH) is a progressive disease that is mainly caused by chronic exposure to high altitude, chronic obstructive lung disease, and obstructive sleep apnea. The increased pulmonary vascular resistance and increased pulmonary arterial pressure result in increased right ventricular afterload, leading to right heart failure and increased morbidity. There are several clinical reports suggesting a link between PH and diabetes, insulin resistance, or obesity; however, it is unclear whether HPH is associated with diabetes as a progressive complication in diabetes.

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43

Gunawardena, A. H. L. A. N. "Investigation of cell death and aerenchyma formation in roots of maize (Zea mays l.)." Thesis, Oxford Brookes University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322185.

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44

Lequeux, Audrey. "Impact du ciblage du domaine de liaison de HIF-1α avec HIF-1β sur le paysage immunitaire du mélanome Targeting HIF-1 Alpha Transcriptional Activity Drives Cytotoxic Immune Effector Cells into Melanoma and Improves Combination Immunotherapy Hijacker of the Antitumor Immune Response: Autophagy is Showing its Worst Facet Impact of Hypoxic Tumor Microenvironment and Tumor Cell Plasticity on The Expression of Immune Checkpoints Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL026.

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L’hypoxie est une caractéristique majeure des tumeurs solides et elle est capable d’induire un microenvironnement tumoral immunosuppressif. Nous avons étudié l’impact de l’inhibition du domaine de liaison de HIF-1α avec HIF-1β sur le paysage immunitaire du mélanome murin B16-F10. Le ciblage de ce domaine de liaison inhibe l’activité transcriptionnelle de HIF-1α dans les cellules B16-F10 in vitro. In vivo, l’inhibition de l’activité transcriptionnelle de HIF-1α dans le mélanome B16-F10 montre une diminution significative de la croissance tumorale et une amélioration consistante de la survie des

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45

Sipe, Conor W. "Cloning and Functional Characterization of Hypoxia-Inducible Factor 1alpha Upstream Regions in Xenopus laevis." W&M ScholarWorks, 2003. https://scholarworks.wm.edu/etd/1539626407.

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46

Faysal, Joanne M. "The Effects of Hypoxia with Concomitant Acidosis on Prostate Cancer Cell Survival." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_theses/69.

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Prostate cancer is the second most common cancer among men in the United States. While treatments for prostate cancer exist, none are curative. As a solid tumor, prostate cancer can grow beyond the diffusion limits of oxygen, thereby resulting in a hypoxic environment. While hypoxia can cause death to a variety of cell types, tumor cells can develop resistance to hypoxia and survive under minimal oxygen conditions. Hypoxia in tumor cells has also been associated with poor prognosis, increased metastasis, and decreased efficacy of chemotherapy. BNIP3, a BH-3 only proapoptotic Bcl-2 family

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47

Sheares, Karen Kwie Kay. "The regulation of human pulmonary artery smooth muscle cell growth by hypoxia." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614833.

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48

Ahmed, Muhammad A. "Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology." Thesis, Keele University, 2018. http://eprints.keele.ac.uk/4532/.

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Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tissue to another ranging from 0.002% to 10% and substantially lower than the atmospheric level of 21 % O2. Hypoxia is defined as a state of reduced O2 supplied to cells or tissues when compared to their normal physiological levels. Hypoxia mimetic agents (HMAs) are chemical used to induce pharmacological hypoxia without affecting environmental oxygen

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Bowler, E. "The effect of hypoxia on alternative splicing in prostate cancer cell lines." Thesis, University of the West of England, Bristol, 2017. http://eprints.uwe.ac.uk/30029/.

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Hypoxia is defined as the state in which the availability or delivery of oxygen is insufficient to meet tissue demand. It occurs particularly in aggressive, fast-growing tumours in which the rate of new blood vessel formation (angiogenesis) cannot match the growth rate of tumour cells. Cellular stresses such as hypoxia can cause cells to undergo apoptosis; however some tumour cells adapt to hypoxic conditions and evade apoptosis. Tumour hypoxia has been linked to poor prognosis and to greater resistance to existing cancer therapies. This thesis provides evidence that alterations in alternative

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50

Gustafsson, Maria. "Signal integration between notch and hypoxia : insights into development and disease /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-090-9/.

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