Academic literature on the topic 'CEL reasoner'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'CEL reasoner.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "CEL reasoner"
1
Mukantayev, T. E. "Laparoscopic endocystectomy in patients with liver echinococcosis." Kazan medical journal 96, no. 2 (April 15, 2015): 138–43. http://dx.doi.org/10.17750/kmj2015-138.
Full textAbstract:
Aim. To evaluate the efficiency and to review the indications for laparoscopic endocystectomy in liver echinococcosis.Methods. The results of laparoscopic endocystectomy in 86 patients treated for liver echinococcosis compared to cystectomy by laparotomy in 159 patients are presented.Results. Optimal characteristics for laparoscopic endocystectomy were types CL, CE1-CE3 of cystic echinococcosis according to cystic echinococcosis ultrasonic classification by H.A. Gharbi (1981) modified by World Health Organization (2003) with cysts localized in 2-6 liver segments; partial superficial location of cysts; cyst size not less than 5 cm; no cysts in 1, 7 and 8 liver segments or deeply located cysts of any size, as well as cysts of CE4-CE5 types. Of the 86 cases in which laparoscopic endocystectomy was completed successfully, in 4 patients the surgery was continued by a laparotomy access. The reasons for the continuation with laparotomy were unsuccessful attempts for stable hemostasis at resection of liver fibrous capsule excesses (1 case), presence of large fistula between the cyst and components of the biliary system at the bottom of the fibrous cavity (2 patients), and location of the second cyst in the segment unavailable for laparoscopic manipulation (1 case). The frequency of early complications after laparoscopic endocystectomy was 15.1% (p=0.23). Relapse occurred in 1 (1.2%) patient (p=0.23). Comparative assessment of echinococcosis recurrence risk in different periods (Kaplan-Meier analysis) after laparoscopic interventions and laparotomy, both followed by albendazole treatment, did not identify any statistically significant differences.Conclusion. The early and long-term effects of laparoscopic endocystectomy in liver echinococcosis are not inferior to conventional laparotomy if indications are strictly followed.
2
Becker, Niklas, and Andrzej Cieślik. "Determinants of German Direct Investment in CEE Countries." Journal of Risk and Financial Management 13, no. 11 (November 2, 2020): 268. http://dx.doi.org/10.3390/jrfm13110268.
Full textAbstract:
This paper studies the determinants of German direct investment in the Central and Eastern European countries during the period 1996–2016 using the augmented Knowledge Capital model to identify the main reasons for foreign direct investment (FDI). The empirical results show increasing multinational enterprise (MNE) activity with growth in country-size and with growing similarities of countries, which supports the horizontal reason for FDI; while the difference in the share of skilled labor force associated with the vertical reason has no effect. Furthermore, the estimation results show unimportance of trade costs to the foreign market and the significance of the distance between source and host countries.
3
Krystynowicz, Alina, Maria Koziołkiewicz, Agnieszka Wiktorowska-Jezierska, Stanisław Bielecki, Emilia Klemenska, Aleksander Masny, and Andrzej Płucienniczak. "Molecular basis of cellulose biosynthesis disappearance in submerged culture of Acetobacter xylinum." Acta Biochimica Polonica 52, no. 3 (September 30, 2005): 691–98. http://dx.doi.org/10.18388/abp.2005_3432.
Full textAbstract:
Acetobacter xylinum strains are known as very efficient producers of bacterial cellulose which, due to its unique properties, has great application potential. One of the most important problems faced during cellulose synthesis by these bacteria is generation of cellulose non-producing cells, which can appear under submerged culture conditions. The reasons of this remain unknown. These studies have been undertaken to compare at the molecular level wild-type, cellulose producing (Cel(+)) A. xylinum strains with Cel(-) forms of cellulose-negative phenotype. Comparison of protein profiles of both forms of A. xylinum by 2D electrophoresis allowed for the isolation of proteins which were produced exclusively by either Cel+ or Cel- cells. Sequences of peptides derived from these proteins were aligned with those of proteins deposited in databases. This analysis revealed that Cel(-) cells lacked two enzymes: phosphoglucomutase and glucose-1-phosphate uridylyltransferase, which generates UDP-glucose being the substrate for cellulose synthase. DNA was analyzed by ligation-mediated PCR carried out at low denaturation temperature (PCR-MP). Two DNA fragments of different thermal stability (218 and 217 bp) were obtained from the DNA of Cel(+) and Cel(-) forms, respectively. The only difference between these Cel(-) and Cel(+) DNA fragments is deletion of one T residue. Alignment of those two sequences with those deposited in the GenBank database revealed that similar fragments are present in the genomes of some bacterial cellulose producers and are located downstream from open reading frames (ORF) encoding phosphoglucomutase. The meaning of this observation is discussed.
4
Riedell, Peter A., Chase Walling, Loretta J. Nastoupil, Martina Pennisi, Richard T. Maziarz, Joseph P. McGuirk, Olalekan O. Oluwole, et al. "A Multicenter Retrospective Analysis of Clinical Outcomes, Toxicities, and Patterns of Use in Institutions Utilizing Commercial Axicabtagene Ciloleucel and Tisagenlecleucel for Relapsed/Refractory Aggressive B-Cell Lymphomas." Blood 134, Supplement_1 (November 13, 2019): 1599. http://dx.doi.org/10.1182/blood-2019-127490.
Full textAbstract:
Introduction CD19 directed CAR T cells have shown potent activity in relapsed/refractory (R/R) aggressive B-cell lymphomas (B-NHL) leading to the FDA approval of axicabtagene ciloleucel (axi-cel, Oct 2017) and tisagenlecleucel (tisa-cel, May 2018). Initial reports on commercial application of axi-cel suggest many patients (pts) would not have met eligibility criteria for the ZUMA-1 clinical trial, yet outcomes and toxicities appeared similar (Nastoupil LJ, et al. Blood 2018 132:91 and Jacobson CA, et al. Blood 2018 132:92). No data on the "real world" application of tisa-cel is available. We performed a multicenter retrospective study to include both approved commercial products, axi-cel and tisa-cel, given in centers that had the option of prescribing either product. We evaluate patterns of use, efficacy, and safety. Methods We retrospectively analyzed data from pts who underwent apheresis for commercial axi-cel or tisa-cel from 8 US academic centers. Data collection started after 5/1/2018, following FDA approval of tisa-cel when centers would have a choice to prescribe either axi-cel or tisa-cel for B-NHL. Centers were invited to participate if they were certified to administer both products. Patient and treatment characteristics were summarized descriptively. Response and toxicity were reported with 95% exact binomial CIs. Results As of 7/31/2019, 242 pts underwent apheresis for commercial CAR T-cell products. Of these, 163 (67%) underwent apheresis for axi-cel, and 79 (33%) for tisa-cel. 14 (9%) axi-cel and 3 (4%) tisa-cel pts died prior to CAR T-cell infusion from lymphoma progression, and 1 (1%) tisa-cel pt was not infused for other reasons. Detailed baseline pt characteristics were available for 180/242 pts (Table 1). Median age at apheresis was 58 years (range: 18-85) for axi-cel pts and 67 years (range: 36-88) for tisa-cel pts. ECOG PS was 0-1 in 86% of axi-cel and 94% of tisa-cel pts. By histology, 77% of axi-cel pts had DLBCL, 13% TFL, 9% HGBL and 2% PMBCL. Similarly, 81% of tisa-cel pts had DLBCL, 13% HGBL, and 6% TFL. The median number of prior therapies was 3 (range: 2-11) for axi-cel and 4 (range: 2-9) for tisa-cel pts. Prior autologous stem cell transplant was performed in 29% of axi-cel and 23% of tisa-cel pts, respectively. Bridging therapy was given in 61% of axi-cel and 72% of tisa-cel pts. Median time from apheresis to CAR T-cell infusion was 28 days for axi-cel and 44 days for tisa-cel. CAR T-cell infusion was inpatient in 100% of axi-cel and 39% of tisa-cel pts. Safety was evaluable in 213 pts. CRS was graded according to institutional practices (CARTOX (38%), Penn scale (31%), ASTCT (19%), and Lee scale (11%)). NEs were graded per CARTOX (80%), ASTCT (19%), or CTCAE V4.03 (1%). Grade ≥3 CRS and NEs occurred in 13% and 41% of axi-cel pts and 1% and 3% of tisa-cel pts. The median onset of CRS and NEs was 2 and 6 days in axi-cel, and 3 and 5 days in tisa-cel treated pts, respectively. Tocilizumab was administered in 62% of axi-cel pts with 57% receiving steroids. In tisa-cel pts, tocilizumab was administered in 13% of cases, with 7% receiving steroids. 12 deaths (8%) unrelated to lymphoma progression occurred in axi-cel pts at a median of 57 days (range: 6-373) with 5 due to infectious complications, 4 due to grade 5 NEs, 1 due to cardiac disease, 1 due to pulmonary hemorrhage, and 1 due to HLH. 4 deaths (6%) unrelated to lymphoma progression occurred in tisa-cel pts at a median of 48 days (range: 25-146) with 2 due to infectious complications, 1 due to cardiac disease, and 1 due to unknown causes. Response assessment was performed for infused pts at day 30 and/or day 90, or in those determined to have clinical progression. Of 120 axi-cel pts evaluable at day 30, the ORR was 72% with 43% achieving a CR. Of the 32 tisa-cel pts evaluable at day 30, the ORR was 59% with 44% achieving a CR. At day 90, the ORR for axi-cel was 52% with 39% achieving a CR, while for tisa-cel the ORR was 48% with 39% achieving a CR. Conclusions Efficacy outcomes in the commercial setting appear similar to responses seen in the pivotal clinical trials. Though different toxicity grading scales were employed, tisa-cel appears to be associated with less CRS and NEs. Data from a larger group of pts treated at additional centers are being gathered. Analyses of usage patterns and updated outcomes with uniform ASTCT toxicity grading will be presented in an effort to better understand therapeutic decision making. Disclosures Riedell: Novartis: Research Funding; Verastem: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Kite/Gilead: Honoraria, Research Funding, Speakers Bureau; Bayer: Honoraria, Speakers Bureau. Nastoupil:Spectrum: Honoraria; TG Therapeutics: Honoraria, Research Funding; Novartis: Honoraria; Janssen: Honoraria, Research Funding; Gilead: Honoraria; Genentech, Inc.: Honoraria, Research Funding; Bayer: Honoraria; Celgene: Honoraria, Research Funding. Maziarz:Kite: Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Research Funding; Incyte: Consultancy, Honoraria; Celgene/Juno: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding. McGuirk:Gamida Cell: Research Funding; Pluristem Ltd: Research Funding; Novartis: Research Funding; Fresenius Biotech: Research Funding; Astellas: Research Funding; Bellicum Pharmaceuticals: Research Funding; Kite Pharmaceuticals: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Juno Therapeutics: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; ArticulateScience LLC: Other: Assistance with manuscript preparation. Oluwole:Pfizer: Consultancy; Spectrum: Consultancy; Gilead Sciences: Consultancy; Bayer: Consultancy. Bachanova:Novartis: Research Funding; Celgene: Research Funding; Kite: Membership on an entity's Board of Directors or advisory committees; Incyte: Research Funding; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees; Gamida Cell: Research Funding; GT Biopharma: Research Funding. Hwang:Tmunity: Research Funding; Novartis: Research Funding. Schuster:Pharmacyclics: Honoraria, Research Funding; Acerta: Honoraria, Research Funding; AstraZeneca: Honoraria; Loxo Oncology: Honoraria; Nordic Nanovector: Honoraria; Pfizer: Honoraria; Novartis: Honoraria, Patents & Royalties: Combination Therapies of CAR and PD-1 Inhibitors with royalties paid to Novartis, Research Funding; Celgene: Honoraria, Research Funding; Genentech: Honoraria, Research Funding; Merck: Honoraria, Research Funding; AbbVie: Honoraria, Research Funding; Gilead: Honoraria, Research Funding. Perales:Bellicum: Honoraria, Membership on an entity's Board of Directors or advisory committees; Abbvie: Honoraria, Membership on an entity's Board of Directors or advisory committees; NexImmune: Membership on an entity's Board of Directors or advisory committees; MolMed: Membership on an entity's Board of Directors or advisory committees; Omeros: Honoraria, Membership on an entity's Board of Directors or advisory committees; Bristol-Meyers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Nektar Therapeutics: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees; Merck: Consultancy, Honoraria; Medigene: Membership on an entity's Board of Directors or advisory committees; Servier: Membership on an entity's Board of Directors or advisory committees; Kyte/Gilead: Research Funding; Miltenyi: Research Funding. Bishop:Juno: Consultancy, Membership on an entity's Board of Directors or advisory committees; CRISPR Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Kite: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Porter:American Board of Internal Medicine: Membership on an entity's Board of Directors or advisory committees; Immunovative: Membership on an entity's Board of Directors or advisory committees; Genentech: Employment; Wiley and Sons: Honoraria; Incyte: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees, Patents & Royalties, Research Funding; Kite: Membership on an entity's Board of Directors or advisory committees; Glenmark Pharm: Membership on an entity's Board of Directors or advisory committees.
5
Jacobson, Sansea L. "Thirteen reasons to be concerned about 13 Reasons Why." Brown University Child and Adolescent Behavior Letter 33, no. 6 (May 23, 2017): 8. http://dx.doi.org/10.1002/cbl.30220.
Full text
6
Howard, Ravi. "Rites and Reasons." Callaloo 38, no. 2 (2015): 360–64. http://dx.doi.org/10.1353/cal.2015.0046.
Full text
7
Lavender, Bill. "The Reason." Callaloo 29, no. 4 (2006): 1486–89. http://dx.doi.org/10.1353/cal.2007.0039.
Full text
8
Omodero, Cordelia Onyinyechi. "The Consequences of Indirect Taxation on Consumption in Nigeria." Journal of Open Innovation: Technology, Market, and Complexity 6, no. 4 (October 7, 2020): 105. http://dx.doi.org/10.3390/joitmc6040105.
Full textAbstract:
This research tests the consequences of Nigeria’s indirect taxes on consumption. There are two reasons why the government imposes taxes on goods and services in Nigeria. The primary purpose is to produce income for the smooth running of the administration. Another silent reason is to discourage the ingestion of prohibited products and services, and that is through customs and excise duties (CED). This study assesses both Value Added Tax (VAT) and CED to determine their effects on consumption using various econometric tools, such as trend analysis, pairwise Granger causality tests, unrestricted co-integration rank test, least squares technique, and data that cover the period from 2005 to 2019. The results indicate that VAT insignificantly but positively influences consumption, while CED has a considerable auspicious influence on use. This result shows that VAT imposition on merchandises and services is discouraging the absorption of specific foodstuffs and services and allowing the operation of informal economic activities to thrive in Nigeria. However, CED charges do not reduce the use of certain illegal products purposely taxed to discourage their consumption. This study recommends a reduction in the prices of food items and services to enable consumers to increase their patronage, while the products that attract CED but are harmful should be banned entirely. Thus, offenders should be allowed to face the wrath of the law.
9
Mracek, Jan, Jakub Kletecka, Irena Holeckova, Jiri Dostal, Jolana Mrackova, Jan Mork, and Vladimir Priban. "Patient Satisfaction with General versus Local Anesthesia during Carotid Endarterectomy." Journal of Neurological Surgery Part A: Central European Neurosurgery 80, no. 05 (April 29, 2019): 341–44. http://dx.doi.org/10.1055/s-0039-1688692.
Full textAbstract:
Background and Study Aims Both general and local anesthesia are used in our department for carotid endarterectomy (CEA). The decision as to which anesthetic technique to use during surgery is made individually. The aim of our study was to evaluate patient satisfaction and preference with the anesthesia type used. Material and Methods The satisfaction of a group of 205 patients with regard to anesthesia used and their future preferences were evaluated prospectively through a questionnaire. The reasons for dissatisfaction were assessed. Results CEA was performed under general anesthesia (GA) in 159 cases (77.6%) and under local anesthesia (LA) in 46 cases (22.4%). In the GA group, 148 patients (93.1%) were satisfied; 30 patients (65.2%) in the LA group were satisfied (p < 0.0001). The reason for dissatisfaction with GA were postoperative nausea and vomiting (7 patients), postoperative psychological alteration (3), and fear of GA (1). The reasons for dissatisfaction with LA were intraoperative pain (9 patients), intraoperative discomfort and stress (5), and intraoperative breathing problems (2). Of the GA group, 154 (96.9%) patients would prefer GA again, and of the LA group, 28 (60.9%) patients would prefer LA if operated on again (p < 0.0001). Overall, 172 patients (83.9%) would prefer GA in the future, and 33 patients (16.1%) would prefer LA. Conclusion Overall patient satisfaction with CEA performed under both GA and LA is high. Nevertheless, in the GA group, patient satisfaction and future preference were significantly higher. Both GA and LA have advantages and disadvantages for CEA. An optimal approach is to make use of both anesthetic techniques based on their individual indications and patient preference.
10
BAUM, RUDY. "Attacks on science require measured, reasoned response." Chemical & Engineering News 73, no. 26 (June 26, 1995): 34. http://dx.doi.org/10.1021/cen-v073n026.p034.
Full textDissertations / Theses on the topic "CEL reasoner"
1
Suntisrivaraporn, Boontawee. "Polynomial-Time Reasoning Support for Design and Maintenance of Large-Scale Biomedical Ontologies." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1233830966436-59282.
Full textAbstract:
Description Logics (DLs) belong to a successful family of knowledge representation formalisms with two key assets: formally well-defined semantics which allows to represent knowledge in an unambiguous way and automated reasoning which allows to infer implicit knowledge from the one given explicitly. This thesis investigates various reasoning techniques for tractable DLs in the EL family which have been implemented in the CEL system. It suggests that the use of the lightweight DLs, in which reasoning is tractable, is beneficial for ontology design and maintenance both in terms of expressivity and scalability. The claim is supported by a case study on the renown medical ontology SNOMED CT and extensive empirical evaluation on several large-scale biomedical ontologies.
2
Suntisrivaraporn, Boontawee. "Polynomial-Time Reasoning Support for Design and Maintenance of Large-Scale Biomedical Ontologies." Doctoral thesis, Technische Universität Dresden, 2008. https://tud.qucosa.de/id/qucosa%3A23678.
Full textAbstract:
Description Logics (DLs) belong to a successful family of knowledge representation formalisms with two key assets: formally well-defined semantics which allows to represent knowledge in an unambiguous way and automated reasoning which allows to infer implicit knowledge from the one given explicitly. This thesis investigates various reasoning techniques for tractable DLs in the EL family which have been implemented in the CEL system. It suggests that the use of the lightweight DLs, in which reasoning is tractable, is beneficial for ontology design and maintenance both in terms of expressivity and scalability. The claim is supported by a case study on the renown medical ontology SNOMED CT and extensive empirical evaluation on several large-scale biomedical ontologies.
3
Vierrath, Severin, Matthias Breitwieser, Matthias Klingele, Benjamin Britton, Steven Holdcroft, Roland Zengerle, and Simon Thiele. "The reasons for the high power density of fuel cells fabricated with directly deposited membranes." Elsevier, 2016. https://publish.fid-move.qucosa.de/id/qucosa%3A72520.
Full textAbstract:
In a previous study, we reported that polymer electrolyte fuel cells prepared by direct membrane deposition (DMD) produced power densities in excess of 4 W/cm2. In this study, the underlying origins that give rise to these high power densities are investigated and reported. The membranes of high power, DMD-fabricated fuel cells are relatively thin (12 μm) compared to typical benchmark, commercially available membranes. Electrochemical impedance spectroscopy, at high current densities (2.2 A/cm2) reveals that mass transport resistance was half that of reference, catalyst-coated-membranes (CCM). This is attributed to an improved oxygen supply in the cathode catalyst layer by way of a reduced propensity of flooding, and which is facilitated by an enhancement in the back diffusion of water from cathode to anode through the thin directly deposited membrane. DMD-fabricated membrane-electrode-assemblies possess 50% reduction in ionic resistance (15 mΩcm2) compared to conventional CCMs, with contributions of 9 mΩcm2 for the membrane resistance and 6 mΩcm2 for the contact resistance of the membrane and catalyst layer ionomer. The improved mass transport is responsible for 90% of the increase in power density of the DMD fuel cell, while the reduced ionic resistance accounts for a 10% of the improvement.
4
Vieira, Filipa Alexandra da Fonseca. "Os comportamentos autolesivos (CAL) e os atos suicidários numa amostra de adolescentes." Master's thesis, 2017. http://hdl.handle.net/10400.12/5786.
Full textAbstract:
Dissertação de Mestrado apresentada no ISPA - Instituto Universitário para a obtenção de grau de Mestre na especialidade de Psicologia ClínicaOs comportamentos autolesivos (CAL) e os atos suicidas são considerados um problema de saúde pública, principalmente na camada jovem, daí a pertinência em estudar estes fenómenos. Sendo assim estudaram-se os CAL e as suas funções, a ideação suicida (IS), as tentativas de suicídio (TS) e as razões para viver. Ao nível das funções dos CAL, analisou-se qual a função mais utilizada, as diferenças existentes entre quem se magoa intencionalmente e quem não o faz e ao nível do género (feminino e masculino). Quanto aos CAL, foram analisadas as suas ligações aos adolescentes com TS prévia, à ideação suicida e com as Razões para Viver. Relativamente às Razões para Viver, verificou-se a sua ligação com a ideação suicida e tentou-se compreender se existiam (ou não) diferenças entre os adolescentes praticantes de CAL mais IS e os que apenas praticam CAL. Participaram 290 adolescentes, com idades compreendidas entre os 14 e os 18 anos. Os inquiridos pertenciam à área da Grande Lisboa e de Alverca. Foi pedido que respondessem a um conjunto de escalas, sendo elas: Inventário dos Comportamentos Autolesivos, Inventário das Funções dos Comportamentos Autolesivos, Inventário das Razões para Viver e o Questionário de Ideação Suicida. É de máxima importância que se continue a investigar estes comportamentos na população portuguesa, de forma a que possamos compreender estes comportamentos, pois só assim os conseguimos prevenir e intervir em quem já os pratica. É necessário também quebrar o tabu existente na sociedade, relativamente a estas problemáticas e à saúde mental, pois só assim os jovens pedirão ajuda.
Self-injurious behavior (SIB) and suicidal acts are considered a public health concern, specifically in the younger tissue of society, raising the necessity of studying these phenomena. This framework aimed to contribute with more information regarding these public health issues to the Portuguese literature, and also to fully comprehend and gain knowledge about these behaviors. Knowing this, SIB and respective functions of suicidal ideation (SI), suicide attempts (SA) and reasons for living were analyzed. Considering SIB functions, we analyzed which function was the most used one, the differences that exist between intentional self-promoted lesions and who doesn’t engage in SIB, and the genre disparity (male versus female). Regarding SIB itself, we analyzed the connection of the prior to teenagers with previous reported SA, to SI, and reasons to live. Considering reasons to live, we focused on the connection with ideation and we tried to comprehend if there exist (or not) differences between SIB plus SI- practicing teenagers, and the practicing-only SIB teenagers. 290 adolescents participated within a range of 14 to 18 years of age, belonging to Greater Lisbon’s areas and Alverca. It was requested that the partaken would answer to several scales, specifically the Inventory of Self-injurious Behaviors, Inventory of the Functions of Selfinjurious Behaviors, Inventory of Reasons for Living and the Suicidal Ideation Questionnaire. In conclusion, it is of upmost urgency that these behaviors continue to be case studied in the Portuguese population, in order to fully comprehend these and to partake in future actions of prevention and intervention on teenagers who already demonstrate these. It is necessary to break the existing stigma in society concerning these and mental health-related problematics, to allow and promote the younger tissue of society to search for help.
5
Cheng, Li-Chi, and 鄭笠綺. "Study of the reason responsible for the early cell lysis caused by substitutions for the three basic amino acid residues in subregion 1.2 of Bacillus subtilis σA factor." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/v58835.
Full textAbstract:
碩士國立中興大學
生物化學研究所
103
The primary σ factor of Bacillus subtilis, σA, comprises four conserved regions, each containing two to four subregions. It was found that deletion of 103 amino acid residues from the N terminus of the σA would affect the efficiency of promoter DNA binding of the truncated σA-RNA polymerase, the stability of the closed binary complex and the efficiency of open complex formation. Sequence alignment of σ factor has revealed three conserved basic amino acid residues, R103, K107, and R111, in the N-terminus of subregion 1.2 of Bacillus subtilis σA factor. On the basis of a homology model structure of B. subtilis σA-RNA polymerase derived from the crystal structure of Thermus aquaticus σA-RNA polymerase, Arg-103 and Lys-107 are located on the same side of the first alpha-helix of a ''helix-loop-helix'' motif in subregion 1.2 and their side chains are on the same orientation with the side chain of Arg-111, which is the second residue of the subsequent loop. Moreover, when the σA-RNA polymerase is complexed with a fork-junction promoter DNA, Arg-103 and Lys-107 are predicted to interact with Pro-242 and Gly-243 of the beta subunit through van der Waals interaction, and Arg-111 with Lys-147 of the beta’ subunit through hydrogen bonding. The recent work has demonstrated that replacement of the three basic amino acids with alanine would result in a early cell lysis phenotype of the mutant sigA strain, B. subtilis DB2HY7. This study is aimed to answer how can replacement of the three basic amino acids of the σA with alanine lead to lysis of the cells during early sporulation and what is the functional defect of the mutant σA during transcription. To fulfill this goal, both the wild-type (Wt) and mutant σA factors were overexpressed, purified and used to reconstitute with the purified core RNA polymerase. The reconstituted Wt and mutant σA-RNA polymerase holoenzymes were then used to transcribe in vitro five selected spo0 promoters, including spo0A, spo0B, spo0E, spo0F and kinB, which all belong to the phosphorelay of early sporulation. The results showed that the mutant σA-RNA polymerase is weaker on transcribing all of the spo0 promoters comparing with the Wt σA-RNA polymerase, especially on spo0A, of which the protein product, Spo0A, is a master DNA-binding regulatory protein and regulates directly or indirectly the expression of over 500 genes during the early stages of development. Since the Wt and mutant σA-RNA polymerases have similar binding activities on the spo0A promoter DNA as analyzed by electrophoretic mobility shift assay (EMSA). I infer that the mutant σA-RNA polymerase may be defective in forming a stable closed complex or in forming a functional open complex with at least the spo0A promoter.
Books on the topic "CEL reasoner"
1
Board, Ontario Environmental Assessment. In the matter of an application by the Corporation of the Tonwship of Edwardsburgh for approval of the construction of sanitary sewage works, pumping stations and force mains and a two cell waste stabilization lagoon, and for the approval of issuance of debentures and the enactment of proposed by-laws: Decision and reasons for decision of the Joint Board dated December 7, 1988. S.l: s.n, 1988.
Find full text
2
McGlynn, Katherine A., Ewa Rajpert-De Meyts, and Andreas Stang. Testicular Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0054.
Full textAbstract:
Testicular cancer is a rare cancer in the general population, but is the most common neoplasm among young men in many countries. It has one of the highest heritabilities of all cancer types. The vast majority of testicular cancers are germ cell tumors; thus the terms “testicular cancer” and “testicular germ cell tumors” (TGCTs) are often used interchangeably. Globally, the incidence of testicular cancer is highest among men of European ancestry and lowest among men of African and Asian ancestries. Incidence rates have been increasing in many countries since at least the mid-twentieth century. Mortality rates, however, have sharply declined in developed countries. While the reason for the decline in mortality rates is well known, reasons for the increase in incidence remain poorly understood. Accumulating evidence supports the hypothesis that most TGCTs are linked to disturbed development of the testes, beginning in utero, but fostered by postnatal events.
3
Fitzpatrick, T. M. Letticia Cellbridge's Official Guide To Cell Phone Etiquette / 71 Reasons To Get Off The !@#XX Cell Phone by Sgt. Sam Hammer. Center for Entrepreneurial Success, 2001.
Find full text
4
Lefebvre, Tony, and Tarik Issad, eds. 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation. Frontiers Media SA, 2015. http://dx.doi.org/10.3389/978-2-88919-591-6.
Full text
5
Bunch, Chris. Myelodysplasia. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0288.
Full textAbstract:
The myelodysplastic syndromes (or myelodysplasias) comprise a spectrum of disorders characterized by dysplastic or ineffective haemopoiesis that leads to variable anaemia, neutropenia, and thrombocytopenia. There is often a degree of red-cell macrocytosis. The majority are clonal stem cell disorders in which the abnormal clone predominates and expands only slowly over a number of years. Myelodysplasias have a tendency to develop ultimately into acute leukaemia in some patients; for this reason, they are sometimes referred to as ‘preleukaemias’, even though two-thirds of patients will never develop this complication. This chapter addresses the causes, diagnosis, and management of myelodysplastic syndromes.
6
LaGrave, Danielle, Patricia L. Devers Winters, and Geralyn Lambert-Messerlian. Prenatal Screening Technologies and Test Issues. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190604929.003.0007.
Full textAbstract:
Maternal serum screening began with the measurement of serum alpha fetal protein to detect open neural tube defects, which led to the implementation of routine serum-based prenatal screening in the second trimester for Down syndrome. Advances via combined and integrated screening allowed for the first-trimester detection of both Down syndrome and trisomy 18. Next-generation sequencing has enabled the identification of aneuploidies in circulating cell-free fetal DNA from the plasma fraction of maternal whole blood. This breakthrough in molecular genetic testing, commonly referred to as noninvasive prenatal testing, has revolutionized prenatal screening and testing for genetic disorders without posing additional risk to the pregnancy. This chapter reviews the history of maternal serum screening, the disorders it can detect, the methods of calculating patient-specific risk, and reasons for recalculation or adjustment of risk. This chapter also reviews of cell-free DNA-based testing for fetal aneuploidies, including its limitations and potential.
7
Townsend, William M., and Emma C. Morris. ICU selection and outcome of patients with haematological malignancy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0374.
Full textAbstract:
Patients with haematological malignancies require admission to the intensive care unit (ICU) due to the underlying disease, as a consequence of treatment with chemotherapy or after haematopoietic stem cell transplantation. With an increasing numbers of patients being diagnosed with these diseases and longer survival as treatments improve, the burden on ICU is anticipated to increase. There is compelling evidence that patients should not be denied admission to ICU based on the presence of a haematological malignancy. In this chapter the disease- and treatment-related reasons for ICU admission, outcome, and risk prediction scores for patients with haematological malignancies are discussed.
8
Hopkins, William D., Cheryl D. Stimpson, and Chet C. Sherwood. Social cognition and brain organization in chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198728511.003.0014.
Full textAbstract:
Bonobos and chimpanzees are two closely relates species of the genus Pan, yet they exhibit marked differences in anatomy, behaviour and cognition. For this reason, comparative studies on social behaviour, cognition and brain organization between these two species provide important insights into evolutionary models of human origins. This chapter summarizes studies on socio-communicative competencies and social cognition in chimpanzees and bonobos from the authors’ laboratory in comparison to previous reports. Additionally, recent data on species differences and similarities in brain organization in grey matter volume and distribution is presented. Some preliminary findings on microstructural brain organization such as neuropil space and cellular distribution in key neurotransmitters and neuropeptides involved in social behaviour and cognition is presented. Though these studies are in their infancy, the findings point to potentially important differences in brain organization that may underlie bonobo and chimpanzees’ differences in social behaviour, communication and cognition. Les bonobos et les chimpanzés sont deux espèces du genus Pan prochement liées, néanmoins ils montrent des différences anatomiques, comportementales et cognitives marquées. Pour cette raison, les études comparatives sur le comportement social, la cognition et l’organisation corticale entre ces deux espèces fournissent des idées sur les modèles évolutionnaires des origines humaines. Dans ce chapitre, nous résumons des études sur les compétences socio-communicatives et la cognition sociale chez les chimpanzés et les bonobos de notre laboratoire en comparaison avec des rapports précédents. En plus, nous présentons des données récentes sur les différences et similarités d’organisation corticale du volume et distribution de la matière grise entre espèces. Nous présentons plus de résultats préliminaires sur l’organisation corticale microstructurale comme l’espace neuropile et la division cellulaire dans des neurotransmetteurs clés et les neuropeptides impliqués dans le comportement social et la cognition. Bien que ces études sont dans leur enfance, les résultats montrent des différences d’organisation corticale importantes qui sont à la base des différences de comportement social, la communication et la cognition entre les bonobos et les chimpanzés.
9
McCann, Shaun R. Molecules, genes, and gene therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0009.
Full textAbstract:
The twenty-first century has brought many innovations in haematology, with improved diagnostic technology, which may inform treatment choices for malignant diseases, and a better understanding of the genetics and/or epigenetics underlying many diseases. Unfortunately, the aetiology of most of these diseases still eludes us, and some common diseases such as sickle cell disease await simple, inexpensive, and widely available curative treatment. For reasons that are often obscure, some diseases have become fashionable and attract large research financial backing, whereas some do not. With the advent of advanced technology and an improved understanding of disease mechanisms, most haematological malignancies should enjoy the same success as the treatment of childhood acute lymphoblastic leukaemia and chronic myeloid leukaemia.
10
Grulich, Andrew E., Fengyi Jin, and I. Mary Poynten. Anal Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0037.
Full textAbstract:
Anal canal cancer is a generally uncommon cancer that has been increasing in incidence for several decades. In most geographic locations, squamous cell carcinoma (SCC) accounts for 70% or more of cases, and incidence is slightly higher in women than in men. The remaining cases are mainly adenocarcinoma, but the degree to which this represents misclassified rectal cancer is uncertain. In almost all cases, anal SCC is caused by persistent infection with high-risk types of human papillomavirus (HPV); HPV-16 accounts for 75% or more of all cases. Survival is highly stage-dependent, and cure is usual if the cancer is diagnosed early. The main risk factor is anal exposure to HPV, and for this reason homosexual men are at particularly high risk. In women, risk is increased in those with higher numbers of sexual partners, and in those with a history of HPV-related disease at genital sites.
Book chapters on the topic "CEL reasoner"
1
Baader, Franz, Carsten Lutz, and Boontawee Suntisrivaraporn. "CEL — A Polynomial-Time Reasoner for Life Science Ontologies." In Automated Reasoning, 287–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11814771_25.
Full text
2
Hutto, Daniel D. "Narrative practice and understanding reasons." In Radical Enactivism, 231–47. Amsterdam: John Benjamins Publishing Company, 2006. http://dx.doi.org/10.1075/ceb.2.16hut.
Full text
3
Pina-Vaz, Cidália, Sofia Costa-de-Oliveira, Ana Silva-Dias, Ana Pinto Silva, Rita Teixeira-Santos, and Acácio Gonçalves Rodrigues. "Flow Cytometry in Microbiology: The Reason and the Need." In Single Cell Analysis, 153–70. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4499-1_7.
Full text
4
Manea, Julia, and Robert Pearce. "Reasons for Investing in CEE, Technology and Strategic Evolution of Subsidiaries." In Multinationals and Transition, 52–74. London: Palgrave Macmillan UK, 2004. http://dx.doi.org/10.1057/9780230511811_3.
Full text
5
Airoboman, Abel Ehimen, Patience Ose Airoboman, and Felix Ayemere Airoboman. "Clean Energy Technology for the Mitigation of Climate Change: African Traditional Myth." In African Handbook of Climate Change Adaptation, 1279–92. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45106-6_65.
Full textAbstract:
AbstractThe global Anticipated Energy Transition Period (AETP) is one that all stakeholders must embrace with respect to curbing energy poverty, thereby addressing issues related to climate change especially in the sub-Saharan region of Africa. The region is endowed with abundant richer, cleaner, and affordable energy sources, majority of which has remained untapped due to many reasons, one of which is tied to the socio-cultural traditional beliefs and value systems of the citizens. This has forced majority of the inhabitants to continue to rely on the use of non-biodegradable materials for the purpose of cooking and many other activities. This value system, therefore, contributes to have had an adverse effect on the climate and also on the health of the citizens most of whom are women and children residing in rural areas. The outlook on the AETP, their effect on climate change, the use of Clean Energy Technology (CET) domestically, the various strata expected to come with the AETP, the socio-cultural dynamics in terms of acceptability by all (rural, peri-urban, and urban areas) is addressed in this chapter. The chapter concluded by designing a CET model that could assist in planning for the AETP and mitigating climate change.
6
Barcham, Manuhuia. "Rule by Natural Reason: Late Medieval and early Renaissance conceptions of political corruption." In Corruption: Expanding the Focus. ANU Press, 2012. http://dx.doi.org/10.22459/cef.09.2012.04.
Full text
7
"Cee." In How Noble in Reason, 183–95. A K Peters/CRC Press, 2006. http://dx.doi.org/10.1201/b10577-15.
Full text
8
Govind, Madhu, Ziva Reimer Hassenfeld, and Laura de Ruiter. "Rhyme and Reason." In Teaching Computational Thinking and Coding to Young Children, 84–106. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-7308-2.ch005.
Full textAbstract:
The chapter begins with an exploration of computational thinking (CT) and its relationship to computational literacy, followed by a summary of theoretical and empirical work that aims to elucidate the connections among coding, CT, and literacy. The authors argue that these connections thus far have been predominantly one of support (i.e., unidirectional) and motivated by technological and policy advances, as opposed to considering the connections as mutually reinforcing and developmentally coaligned. The authors discuss the coding as another language (CAL) pedagogical approach, a pedagogy that presents learning to program as akin to learning how to use a new language for communicative and expressive functions, emphasizing the bidirectional connections between the two domains. Finally, the authors detail various curricula that use the CAL approach and discuss the implications of CAL for teaching and learning in early childhood.
9
Hurlbut, J. Benjamin. "Religion, Reason, and the Politics of Progress." In Experiments in Democracy, 233–62. Columbia University Press, 2017. http://dx.doi.org/10.7312/columbia/9780231179546.003.0008.
Full textAbstract:
Chapter 7 examines the politics surrounding California’s stem cell ballot initiative. The chapter explores how the promise of cures derived from human embryonic stem cell research elicited accounts of citizenship and the public good that treated biomedical innovation as an unequivocal public good. The chapter examines how actors used this idea of innovation to construct science and public reason as allied, secular institutions, and critics of the initiative as injecting unwarranted, private religious perspectives into processes of democratic judgment.
10
"Allogeneic haemopoietic stem cell transplantation." In Oxford Handbook of Cancer Nursing, edited by Mike Tadman and Dave Roberts, 269–82. Oxford University Press, 2007. http://dx.doi.org/10.1093/med/9780198569244.003.0021.
Full textAbstract:
Principles 270 Complications of allogeneic transplant 274 Reduced intensity conditioning (RIC) transplants 280 An allogeneic stem cell transplant is where the source of haemopoietic (blood forming) stem cells is from someone other than the patient. There are a number of reasons why an allogeneic stem cell transplant may be useful:...
Conference papers on the topic "CEL reasoner"
1
Takayama, Shuichi, Dongeun Huh, Jonathan Song, Wansik Cha, and Yunseok Heo. "Micro- and Nanofluidics for Cell Biology, Cell Therapy, and Cell-Based Drug Testing." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82151.
Full textAbstract:
Many biological studies, drug screening methods, and cellular therapies require culture and manipulation of living cells outside of their natural environment in the body. The gap between the cellular microenvironment in vivo and in vitro, however, poses challenges for obtaining physiologically relevant responses from cells used in basic biological studies or drug screens and for drawing out the maximum functional potential from cells used therapeutically. One of the reasons for this gap is because the fluidic environment of mammalian cells in vivo is microscale and dynamic whereas typical in vitro cultures are macroscopic and static. This presentation will give an overview of efforts in our laboratory to develop microfluidic systems that enable spatio-temporal control of both the chemical and fluid mechanical environment of cells. The technologies and methods close the physiology gap to provide biological information otherwise unobtainable and to enhance cellular performance in therapeutic applications. Specific biomedical topics that will be discussed include, in vitro fertilization on a chip, microfluidic tissue engineering of small airway injuries, breast cancer metastasis on a chip, electrochemical biosensors, and development of tuneable nanofluidic systems towards applications in single molecule DNA analysis.
2
Haidong, Ma, Wang Yungang, and Zhao Qinxin. "The Effect of Calcium-Bearing Mineral on Ash Melting Behavior During Zhundong Coal Combustion." In ASME 2017 Power Conference Joint With ICOPE-17 collocated with the ASME 2017 11th International Conference on Energy Sustainability, the ASME 2017 15th International Conference on Fuel Cell Science, Engineering and Technology, and the ASME 2017 Nuclear Forum. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/power-icope2017-3221.
Full textAbstract:
Two typical pulverized Zhundong coal with different calcium oxide contents in ash were selected to use in this work. The liquid nitrogen was used to cool ash rapidly at different temperatures, in order to avoid changes in mineral condition. The ash melting behavior and mineral transition mechanism, especially calcium-bearing minerals was studied by ash melting point test platform, XRD, XRF, SEM and EDS. The results showed that the different states of calcium are the dominant reasons for different sintering behaviors of coal ash. The calcium-bearing minerals in ash, such as calcium oxide (CaO), calcium silicate (CaSiO3), gehlenite (2CaO·Al2O3·SiO2), and anorthite (CaO·Al2O3·2SiO2), etc., are the most important factors influencing the initial sintering behavior of coal ash in the temperature range from 1373K to 1473K under oxidizing atmosphere during coal combustion. That is the reason why ash starts to melt at relatively high temperature during ash melting behavior in laboratory, but has severe slagging and contamination characteristic at low temperature during coal combustion in boilers. The research achievments have important guiding significance for the design of partially or completely burning Zhundong coal boiler as well as its long-term safe and efficient operation. (CSPE)
3
Boyarinov, Viktor F., Vladimir I. Bryzgalov, Vladimir D. Davidenko, Peter A. Fomichenko, Evgeny S. Glushkov, Evgeny A. Gomin, Mikhail I. Gurevich, et al. "Results of Neutronic Benchmark Analysis for a High Temperature Reactor of the GT-MHR Type." In Fourth International Topical Meeting on High Temperature Reactor Technology. ASMEDC, 2008. http://dx.doi.org/10.1115/htr2008-58107.
Full textAbstract:
The paper presents a description of benchmark cases, achieved results, analysis of possible reasons of differences of calculation results obtained by various neutronic codes. The comparative analysis is presented showing the benchmark–results obtained with reference and design codes by Russian specialists (WIMS-D, JAR-HTGR, UNK, MCU, MCNP5-MONTEBURNS1.0-ORIGEN2.0), by French specialists (APOLLO2, TRIPOLI4 codes), and by Korean specialists (HELIOS, MASTER, MCNP5 codes). The analysis of possible reasons for deviations was carried out, which was aimed at the decrease of uncertainties in calculated characteristics. This additional investigation was conducted with the use of 2D models of a fuel assembly cell and a reactor plane section.
4
Rajaram, Gukan, Manoj Kumar Panthalingal, and Parthasarathy Valivittan. "Water Management in Fuel Cell Stack by Using Microcontroller." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37901.
Full textAbstract:
Proton Exchange Membrane Fuel Cell (PEMFC) is very good at producing energy without the emission of any harmful gases. In this work, emphasis has been given towards controlling the water accumulation inside the cell stack. The effective cooling of the fuel cell during operation can significantly improve the efficiency. Also, flooding and dehydration conditions are most common reasons for the efficiency reduction and performance degradation of the fuel cells. In the current work, the problem is addressed by controlling the number of cells in operation through a specifically designed microcontroller. The controller would switch the cells on/off when the need arises which can be diagnosed by thermocouple by virtue of cell temperature. Automatic switching with the microcontroller is performed without disturbing the stack operation. This could improve the cell performance with reduced flooding/dehydration of the stack. So the same stack life may be improved substantially.
5
Wang, Yun, and Ken S. Chen. "Predicting Through-Plane Water Distribution in a Polymer Electrolyte Fuel Cell." In ASME 2010 8th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2010. http://dx.doi.org/10.1115/fuelcell2010-33029.
Full textAbstract:
In this paper, a two-dimensional (2D) model is presented for simulating the coupled phenomena of gaseous fuel/reactant flows, species (including liquid water) transport, heat transfer, hydrogen oxidation and oxygen reduction reactions in a PEM fuel cell. A 1D analysis is presented to explain the characteristics of water-content profile at the cathode GDL (gas diffusion layer)-MPL (microporous layer) interface and possible reasons for no experimental observation on the characteristics. 2D model predictions are further computed numerically and compared with available experimental data from neutron imaging. Reasonably good agreements are obtained in comparisons between the computed water profiles and the neutron-imaging data. Case-study simulations are carried out for PEM fuel cell operation at various current densities and 40 °C. The results show that the cathode water content increases with the current density, but the anode side exhibits a complex trend at the considered temperature operation: at high current density the anode water content may become lower partly due to the local heating.
6
Sepehri, A., and K. Farhang. "Closure Equations for CEB Elastic-Plastic Contact." In ASME/STLE 2007 International Joint Tribology Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ijtc2007-44298.
Full textAbstract:
The CEB elastic-plastic contact of nominally flat rough surfaces based on conservation of volume during plastic flow was forwarded by Chang, Etsion and Bogy [1]. The CEB model presents contact force as integral functions of the mean plane separation. A closed-form approximate function providing an explicit relation between contact force and surface parameters and mean plane separation would be desirable for several reasons. First, it facilitates implementation of the contact relation in the dynamics of mechanical system and, second, it provides expediency and efficiency for calculation of contact force when repetitive computation of the contact force is required. This paper presents closed-form approximate equations expressing contact force explicitly as a function of critical interference and mean plane separation. Two alternative approximate equations are provided. The first equation, in simpler form, is shown to yield error within six percent (6%) of the exact integral equations. The second form of approximate equations provides contact force accuracy within 0.1 percent of the original integral equations.
7
Tomiyasu, Joji, Takashi Harada, Makoto Fujiuchi, Takaji Inamuro, Shiaki Hyodo, and Toshihisa Munekata. "Development of Electrode Structure for High Performance Fuel Cell Using CAE." In ASME 2010 8th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2010. http://dx.doi.org/10.1115/fuelcell2010-33330.
Full textAbstract:
Cold starting performance and high temperature operation are current issues in the development of high performance polymer electrolyte fuel cell (PEFC) electrodes. Although excess water must be removed to improve these aspects of electrode performance, it is also important to adopt a structure that prevents the electrodes from drying up. In the face of this conflicting relationship, it is therefore difficult to design an electrode structure with the required properties. For this reason, using technology jointly developed with Kyoto University and Toyota R&D Labs., Inc., the relationship between structural factors and performance was identified by applying a two-phase flow simulation to the complex microstructure of the gas diffusion layer (GDL) to optimize the electrode structure. As a result, an electrode structure was designed that improves high temperature operation while maintaining cold starting performance. The simulation results were then validated by experiments.
8
Roshandel, R., and B. Farhanieh. "The Effect of Variable Catalyst Loading in Electrodes on PEM Fuel Cell Performance." In ASME 2005 3rd International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2005. http://dx.doi.org/10.1115/fuelcell2005-74039.
Full textAbstract:
Catalyst layers are one the important parts of the PEM fuel cells as they are the main place for electrochemical reaction taking place in anode and cathode of the cells. The amount of catalyst loading of this layer has a large effect on PEM fuel cell performance. Non-uniformity of reactant concentration could lead to a variation of current density in anode and cathode catalyst layer. The main reason for this phenomenon is porosity variation due to two effects: 1. compression of electrode on the solid landing area and 2. Water produced at the cathode side of diffusion layer. In this study the effect of variable current density in anode and cathode electrode on cell performance is investigated. It has shown that better cell performance could be achieved by adding a certain amount of catalyst loading to each electrode, with respect to the reactant concentration.
9
Lee, Vivian, and Guohao Dai. "Vasculature Formation Using Three-Dimensional Cell Printing Technology." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19282.
Full textAbstract:
One of the major challenges in tissue engineering is vascularization which provides adequate supplies of oxygen and nutrients to cells within thick tissue-engineered constructs. Oxygen, nutrients and other molecules required for cell growth and survival can only diffuse to 150∼200 μm without proper vascular system. For this reason, thicker tissues have diffusion problems and cannot survive/proliferate well. To date, fabrications of relatively thin tissues such as skin and bladder, and cartilage tissues, which require low level of oxygen and nutrients, are reported. Obstacles in vascularization still exist for thick and complex tissue construct such as kidney, lung and heart (1). Overcoming this problem is a critical step to the clinical applications of tissue engineering (2).
10
Forte, James A., Rifat Sipahi, and Alper Ozturk. "A Novel Device for Nonmagnetic Particle Navigation Using Ferrofluids Manipulated by Magnetic Fields." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67724.
Full textAbstract:
Particle navigation is performed for a variety of reasons including but not limited to drug delivery, cell isolation, sorting and filtering, and cell counting. Current methods accomplish these tasks by ‘tagging’ which has many benefits but also limitations in some cases. This paper proposes a novel device for nonmagnetic non-contact in-vitro particle navigation. The device is based on an idea that utilizes ferrofluids in connection with magnetic fields while effectively removing carriers as required by tagging methods and thus eliminating challenges associated with them. Analytic solution approaches and preliminary results show that this technology has promising potential to profoundly impact the field.