Relevant bibliographies by topics / Cell biology / Dissertations / Theses
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Dissertations / Theses on the topic 'Cell biology'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Einarsson, Elin. "Comparative Cell Biology in Diplomonads." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264541.

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The diplomonads are a diverse group of eukaryotic flagellates found in microaerophilic and anaerobic environments. The most studied diplomonad is the intestinal parasite Giardia intestinalis, which infects a variety of mammals and cause diarrheal disease. Less is known about Spironucleus salmonicida, a parasite of salmonid fish, known to cause systemic infections with high mortality. We created a transfection system for S. salmonicida to study cellular functions and virulence in detail (Paper I). The system was applied to explore the mitochondrion-related organelle (MRO) in S. salmonicida. We
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2

Lewis, Beverley Anne. "Cell biology of rat spermatozoa." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23087.

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The purpose of the research presented in this thesis was to investigate the cell biology of rat spermatozoa. An additional aim was to utilise the knowledge obtained to aid the development of <i>in vitro</i> functional tests for the assessment of rat sperm fertility and identify potential markers of normal epididymal maturation. As mammalian spermatozoa migrate through the epididymis, they acquire the potential for fertilisation, characterised by the acquisition of the ability to express co-ordinated movement and the competence to undergo capacitance. The mechanisms by which epididymal maturati
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3

Yu, Yang. "Lipidomics Investigations in Cell Biology." Doctoral thesis, Università degli studi di Trento, 2014. https://hdl.handle.net/11572/368594.

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Cell membrane is the biological barrier serving as both territorial defense and the communication hinge for the interior of cell from its surroundings. As building blocks of cellular membranes and also precursor for second messengers, a variety of lipids play essential roles in cellular membrane dynamics as well as important functions such as cell proliferation, apoptosis, signal transduction and membrane trafficking modulation. Lipidomics, representing the systematic and integrative studies of diversified lipids (lipidome) in a biological system, is an emerging yet rapid developing field and
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4

Yu, Yang. "Lipidomics Investigations in Cell Biology." Doctoral thesis, University of Trento, 2014. http://eprints-phd.biblio.unitn.it/1294/1/Yang_Yu__Lipidomics_Investigations_in_Cell_Biology.pdf.

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Cell membrane is the biological barrier serving as both territorial defense and the communication hinge for the interior of cell from its surroundings. As building blocks of cellular membranes and also precursor for second messengers, a variety of lipids play essential roles in cellular membrane dynamics as well as important functions such as cell proliferation, apoptosis, signal transduction and membrane trafficking modulation. Lipidomics, representing the systematic and integrative studies of diversified lipids (lipidome) in a biological system, is an emerging yet rapid developing field and
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5

Bair, Elisabeth Laurine. "Cell-cell and cell-matrix interactions involved in cancer invasion." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280673.

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In order for a cancer to metastasize, it must first invade through the basement membrane that surrounds it, invade blood vessels and travel through the bloodstream to a new location where it extravasates the vessel and begins growing at the new site. The mechanisms by which a cancer becomes able to invade and metastasize are currently under intense study. Interactions of the cell with its environment via cell-cell contacts, extracellular matrix (ECM) interactions, and circulating proteins are thought to play a major role in signaling for these invasive processes to occur. Upregulation of prote
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6

Zhang, Yuan. "Cell-cell interactions and Gossypol's effects on cell functions of primary cultured Human Breast Epthelial, Stromal and Adipose Stromal cells /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488187763845791.

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7

Agüera-González, Sonia. "Cell biology on NKG2D ligands and NK cell recognition." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609348.

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8

Camacho, Diogo Mayo. "In silico cell biology and biochemistry: a systems biology approach." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/27960.

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In the post-"omic" era the analysis of high-throughput data is regarded as one of the major challenges faced by researchers. One focus of this data analysis is uncovering biological network topologies and dynamics. It is believed that this kind of research will allow the development of new mathematical models of biological systems as well as aid in the improvement of already existing ones. The work that is presented in this dissertation addresses the problem of the analysis of highly complex data sets with the aim of developing a methodology that will enable the reconstruction of a biological
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9

Buffa, Laura. "Cell Biology of the ICA69 protein family in Neurosecretory cells." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1174057636463-96361.

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In type 1 diabetes (T1D), an autoimmune disease, autoantibodies are preferentially directed against proteins associated with Golgi and post-Golgi secretory vesicles, including insulin secretory granules and synaptic-like microvesicles. Thus, the study of beta-cell autoantigens with yet unknown function may provide novel insight into the secretory machinery of beta-cells and led to the discovery of novel pathways. Islet cell autoantigen of 69 kDa (ICA69) is a T1D autoantigen. It is a cytosolic protein of still unknown function. An impairment in neurotransmitter release upon mutation of its homo
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10

Edwards, T. L. "The molecular cell biology of spartin." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598783.

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This thesis has focused on the protein spartin, which is mutated in a form of autosomal recessive hereditary spastic paraplegia (HSP) called Troyer syndrome. Upon commencement of this project little was known about the likely mechanism of axonopathy in spartin HSP, indeed there was considerable disagreement in the literature as to its precise subcellular localisation. However, a putative role for spartin in endocytosis was proposed due to sequence homology identified with several proteins known to function in this area. This suggested that spartin belonged to an enlarging group of HSP proteins
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11

Yaacob, Nik Soriani. "Molecular cell biology of peroxisome proliferators." Thesis, University of Surrey, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244831.

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12

Marek, Carylyn Jane. "Trans-differentiation and liver cell biology." Thesis, University of Aberdeen, 2004. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU186421.

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Trans-differentiation is the term applied where one fully differentiated cell type changes into another fully differentiated cell type. The AR432J-B13 cell line has been shown to demonstrate this phenomenon in vitro. These cells of exocrine pancreatic lineage, can trans-differentiate into hepatocytes upon treatment with the synthetic glucocorticoid dexamethasone. This thesis demonstrates that the generation of these cells (B13-H) from AR42J-B13 cells could prove to be a novel source of hepatocytes in culture. B13-H cells express functionally active and inducible CYP enzymes for at least 30 day
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13

Scutt, Nanette. "Investigations into the cell biology of tendon & ligament derived cells." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505569.

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14

Maghzal, Nadim. "The epithelial cell adhesion molecule (EpCAM) regulates cell motility and cell-cell adhesion by inhibiting PKC signaling." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114215.

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Tissue cohesion is achieved in part by a large family of plasma membrane-bound cell adhesion molecules (CAMs). During morphogenesis, CAM-mediated interactions provide adhesive forces required for cells to aggregate and form tissues. CAM-mediated adhesions in developing cells are highly dynamic, which provides the fluidity required for cellular movements that drive morphogenesis. Xenopus laevis gastrulation is an established model to study morphogenetic movements. During this phase of development, the mesoderm moves inside the embryo through involution, and migrates along the inner surface of t
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15

Lodato, Michael A. (Michael Anthony). "Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72631.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2012.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>"June 2012." Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>Sox2 is a master regulator of two distinct cellular states, that of pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types not fully understood. Furt
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16

Bergström, Tobias. "Modeling Neural Stem Cell and Glioma Biology." Doctoral thesis, Uppsala universitet, Cancer och vaskulärbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204949.

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This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact with extracellular matrix (ECM) proteins in the stem cell niche, and investigate the consequences of deregulated Platelet-derived growth factor (PDGF) signaling for embryonic NSCs in transgenic mice. Furthermore I present cell cultures of human glioblastoma multiforme (GBM) that models human disease, taking into account the heterogeneity of GBM. Finally, interactions between brain tumors and mast cells are studied using the glioma cultures. In paper I, the importance of NSC interactions with the EC
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17

鍾穗華 and Shui-wah Chung. "Cell-cell interactions in the rat testis: biology and future perspectives." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31238385.

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18

Chung, Shui-wah. "Cell-cell interactions in the rat testis : biology and future perspectives /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2056692X.

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19

San, Roman Adrianna Katrina. "Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226057.

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Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This epithelium thus provides an ideal model to study stem cells and mechanisms of cell differentiation in an adult tissue. The identification of a proliferative population of intestinal stem cells (ISCs) at the base of intestinal crypts presents the prospect of understanding their regulation by extrinsic and intrinsic factors. Although activation of Wnt signaling in ISCs is thought t
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20

Faddah, Dina Adel. "Single-cell analyses of cellular reprogramming and embryonic stem cells." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/89941.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2014.<br>Vita. Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Three years before the start of this thesis, Yamanaka and Takahashi published a groundbreaking paper entitled "Induced of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." A mere two scientists reprogrammed somatic cells to an embryonic stem-cell like state (termed induced pluripotent stem cells, iPSCs) by simply overexpressing four transcription factors: Oct4,
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21

Durán, Ibáñez Sara. "Suspended micro- and nanotools for cell biology." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/285575.

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Esta tesis presenta el diseño, desarrollo tecnológico, caracterización y aplicaciones tanto químicas como biológicas de micro- y nanodispositivos destinados a ser herramientas funcionales en biología celular. Esta línea de investigación es posible gracias a los avances obtenidos en el campo de las Micro- y Nanotecnologías, donde la aplicación de técnicas de miniaturización en la fabricación de sus dispositivos a escala celular es ya una realidad. Estas herramientas son lo suficientemente pequeñas como para etiquetar y permitir el seguimiento de embriones vivos o incluso actuar como sensores p
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22

Diks, Sander Henricus. "Analysis of protein superhighways in cell biology." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/298197421.

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23

Campbell, James Kyle. "Microfluidics for optics and quantitative cell biology." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3290680.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed February 4, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 145-150).
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24

Hinton, I. E. "The developmental biology of Drosophila cell surfaces." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233464.

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25

McNae, Fiona. "The cell biology of non-genotoxic hepatocarcinogens." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260350.

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26

Patterson, James Oliver. "Quantitative biology of cell cycle decision making." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10056386/.

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In the fission yeast Schizosaccharomyces pombe as well as metazoans, the G1/S and G2/M transitions are a focal point of cell cycle regulation. Cells perform these transitions at defined cell sizes, and if born large or small adjust their growth to compensate. The cell cycle is driven by cyclin-CDK activity, and multiple signals are integrated by a single inhibitory phosphorylation site on the CDK1 enzyme. This phosphorylation is regulated by Wee1 kinase and Cdc25 phosphatase. I sought to quantify how and if cell size directly regulates CDK activity in single cells, and to what extent cyclin le
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27

Larocque, Gabrielle. "Cell biology of tumor protein D54 (TPD54)." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/107000/.

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The expression of Tumor protein D52 (TPD52) family members is deregulated in many types of cancer. When overexpressed, it is suggested that they increase cell proliferation and migration/invasion as well as avoid apoptosis. Deregulation in the expression of the TPDs is therefore linked to poor prognosis. Little characterisation has been carried out to date, but it is known that the TPDs are found in association with components of the membrane trafficking pathway. The aim of this work is to uncover how the least studied member of the family, TPD54, affects cellular processes involved in carcino
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28

Trundley, Anita Elizabeth. "Aspects of human uterine NK cell biology." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620028.

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29

Shannon, Matthew Frederick. "The molecular biology of sickle cell anaemia." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/the-molecular-biology-of-sickle-cell-anaemia(d4d29fde-2799-4f3f-b499-b5ae0f5b6782).html.

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Sickle cell anaemia (SCA) is a haemolytic anaemia that reduces life expectancy and places a great burden on healthcare systems worldwide. Despite being a monogenic disorder, the phenotypic severity varies greatly between patients, ranging from patients that experience multiple strokes and organ failure during childhood, to those that live largely unaffected lives. Some genetic variants that affect globin gene expression are known to influence phenotype severity, but most of this variation remains unaccounted for. We conducted whole exome sequencing analyses, comparing SCA patients with mild an
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30

Szymanska, Katarzyna. "Molecular genetics and cell biology of ciliopathies." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/8891/.

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Defects in cilia structure and/or function are now known to be the cause of an important group of Mendelian developmental conditions called ciliopathies. Meckel-Gruber syndrome (MKS) and Joubert syndrome-related disorders (JBTS) are the focus of this work. The research comprised genetic screening of an established MKS/JSRD patient cohort for mutations in seven known genes, and different approaches to identify new causes for these disorders. The latter included whole exome sequencing (WES) of mutation-negative patients, and a high-throughput whole genome siRNA-based reverse genetics screen to i
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31

Chen, Luxi. "Human Innate Lymphoid Cell Biology and Development." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1551901769401192.

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32

Szekely, Tamas. "Stochastic modelling and simulation in cell biology." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f9b8dbe6-d96d-414c-ac06-909cff639f8c.

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Modelling and simulation are essential to modern research in cell biology. This thesis follows a journey starting from the construction of new stochastic methods for discrete biochemical systems to using them to simulate a population of interacting haematopoietic stem cell lineages. The first part of this thesis is on discrete stochastic methods. We develop two new methods, the stochastic extrapolation framework and the Stochastic Bulirsch-Stoer methods. These are based on the Richardson extrapolation technique, which is widely used in ordinary differential equation solvers. We believed that i
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33

Kobert, Antonia. "CNS-resident cells support MS-relevant B-cell responses." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114274.

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The therapeutic success of peripheral B-cell depletion strategies in MS patients has identified B cells as important contributors to new relapsing disease activity in the periphery. However, they may also drive the CNS-compartmentalized inflammatory processes thought to underlie the chronic-progressive stages of disease. The long-term persistence of plasma cells in the CNS of MS patients, and cellular aggregates rich in B cells, T cells and FDC-like cells that have recently been identified in the meningeal compartment, suggest the inflamed MS CNS may be a B-cell fostering environment. The fact
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34

Wredle, Ulla. "Autophagic programmed cell death in the suspensor and endosperm of Vicia faba : An ultrastructural study." Doctoral thesis, Stockholm : Botaniska institutionen, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-123.

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35

Marques, Graça Susete Costa de Carvalho. "Establishing a cell biology platform: isolation and preservation of human blood products." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/11009.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>The use of human primary cells provide researchers in different areas with irrefutable more biologically relevant data than using cell lines or animal blood cells. The work was performed in the scope of the Cell Biology Services @ CEDOC, aiming to provide viable and trustful human primary cells and products. We had three main objectives: protocol optimizations for blood cell isolation, culture and cryopreservation; cost estimation and divulgation of the services. We have reviewed standard protocols and compar
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36

Belbaraka, Loubaba. "Growth, differentiation and cell-cell coupling in the human neuroblastoma cell line SH-SY5Y." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6112.

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Neuroblastoma is one of the most common paediatric solid tumours, frequently occurring in infancy with the primary lesion in the adrenal gland and sympathetic nervous system. It originates from primitive neural crest cells. In rare cases, this tumour regresses spontaneously to a more benign ganglioneuroma probably by neuronal differentiation or apoptosis. We investigated the role of induction of neuronal differentiation and apoptosis in vitro in SH-SY5Y neuroblastoma cells. A variety of agents that are known to induce neuronal differentiation including retinoic acid, nerve growth factor (NGF),
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37

Eastwood, Deborah Jane. "An investigation into the biology of seminoma." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324438.

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Delorme, Marilyne. "Downregulation of ATRX disrupts cell proliferation and cell cycle progression." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27627.

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ATRX is a chromatin remodelling protein of the SNF2 family of chromatin remodelling proteins. Mutations in the ATRX gene have been shown to cause the ATR-X syndrome, an X-linked mental retardation disorder. ATRX is part of a chromatin-remodelling complex with Daxx that localizes to PML nuclear bodies or pericentromeric heterochromatin and is thought to regulate gene expression. In mice, Atrx inactivation results in embryonic lethality whereas conditional forebrain specific Atrx ablation showed impaired development and disorganization of the cortex. Furthermore, ATRX phosphorylation was shown t
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Stimson, Krista Marie. "Cell-Cell Interactions in the Development of the Vascular System of Xenopus." W&M ScholarWorks, 1998. https://scholarworks.wm.edu/etd/1539626164.

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Serpente, Norberto. "Cells from icons to symbols : molecularising cell biology in the 1980’s." Thesis, University College London (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.563093.

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Cornforth, Terri Victoria. "Characterising the cell biology of leukemic stem cells in acute myeloid leukemia." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:654b2176-fd50-427e-86f2-74e928054bef.

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Acute Myeloid leukemia (AML) is an aggressive haematological malignancy that mainly affects the elderly. Relapse is common and is thought to be due to the presence of chemotherapy resistant leukemic stem cells (LSC). Within the CD34+ disease (>5% of the blast cells expressing CD34) , two subtypes have been identified; an LMPP/GMPlike expanded type and a MPP/CMP-like expanded type, the former is the most common, accounting for around 80% of CD34+ AML. Both the GMP-like and LMPPlike expanded populations show LSC activity. To improve our understanding of the disease and gain better insight in to
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42

Xie, Yuan. "Modeling glioblastoma heterogeneity to decipher its biology." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278529.

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Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. We have established and characterized a biobank of 48 cell lines derived from GBM patients. The cells were explanted and maintained as adherent cultures in serum-free, defined neural stem cell medium. These GBM cells (GCs) displayed NSC marker expression in vitro, had orth
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Newman, Jamie Jennifer. "Regulation of gene expression and cell state in embryonic stem cells." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/58526.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2010.<br>"May 2010." Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Cell state is established and maintained through the combined action of transcription factors, chromatin regulators and signaling pathways, which all contribute to a transcriptional regulatory circuitry. Embryonic stem (ES) cells are capable of self-renewal and can give rise to nearly all differentiated cell-types, making them an ideal system in which to address the challenges of understanding gene expression and ce
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Hosseini, Shirazi Seyed Farshad. "Cell cycle dependency of cisplatin cytotoxicity on ovarian cancer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/NQ36776.pdf.

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45

Wearing, Helen Jane. "Mathematical modelling of cell-cell signalling in developmental biology and wound healing." Thesis, Heriot-Watt University, 2001. http://hdl.handle.net/10399/1184.

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Matsiaka, Oleksii. "New mathematical models for cell biology assays incorporating realistic cell size dynamics." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/198192/1/Oleksii_Matsiaka_Thesis.pdf.

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This thesis provides novel insights into several contemporary problems in the mathematical biology involving migration of living cells. Primarily, we focus on cell motility and how dynamic changes in cell size affect collective cell migration. Additionally, this thesis investigates the importance of cellular heterogeneity and how it might affect the choice of modelling techniques we use to describe in vitro cell cultures.
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Fernandez, Daniel. "Cell States and Cell Fate: Statistical and Computational Models in (Epi)Genomics." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226043.

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This dissertation develops and applies several statistical and computational methods to the analysis of Next Generation Sequencing (NGS) data in order to gain a better understanding of our biology. In the rest of the chapter we introduce key concepts in molecular biology, and recent technological developments that help us better understand this complex science, which, in turn, provide the foundation and motivation for the subsequent chapters. In the second chapter we present the problem of estimating gene/isoform expression at the allelic level, and different models to solve this problem. Fir
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48

Raeiszadeh, Mohammad. "Reconstitution of CMV-specific T-cells following adoptive T-cell immunotherapy and haematopoietic stem cell transplantation." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6968/.

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This thesis investigated reconstitution of CMV-specific T-cells in two cohorts of HSCT patients and studied the potential role of Tumour Necrosis Factor Receptor 2 (TNFR2) in regulation of CMV-specific T-cell expansion post HSCT. The first cohort included patients of a randomized phase II trial of adoptive cellular therapy for CMV-specific CD8\(^+\) T-cells. Cellular therapy resulted in earlier and greater expansion of CMV-specific CD8\(^+\) T cells and also reconstitution of CMV-specific CD4\(^+\) and non-infused CMV-specific CD8\(^+\) T-cells. The number of infused therapeutic T-cells and ci
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Bumgarner, Stacie L. "Mechanisms underlying cell-to-cell diversity in clonal populations of yeast." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45150.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references.<br>The FLO promoters are among the largest promoters in yeast and receive a complex combination of signals from upstream signaling pathways through their association with downstream DNA binding factors and chromatin remodelers. The genes regulated by these promoters encode cell-surface glycoproteins that mediate a range of cell-
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Solomon, Jonathan M. (Jonathan Micah). "Cell-cell signaling and the regulation of development in Bacillus subtilis." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/43310.

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