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Dissertations / Theses on the topic 'Cell cycle Transcription factors'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Chen, Xiaoren. "Biochemistry of Prox1 function /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 160 p, 2007. http://proquest.umi.com/pqdweb?did=1456284231&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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2

Rathbone, Christopher R. "Mechanisms regulating skeletal muscle satellite cell cycle progression." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5866.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2006" Includes bibliographical references.

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3

Robinson, Cleo. "The expression and function of B-myb in the cell cycle." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295481.

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4

Maiti, Baidehi. "E2F and survivin - key players in cellular proliferation and transformation." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1173801044.

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5

Xie, Jianxun. "Involvement of transcription factors in cadmium-induced apoptosis and cell cycle arrest in rat kidney cells /." View online ; access limited to URI, 2005. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3206258.

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6

Su, Yingtao. "Function and regulation of myc-family bHLHZip transcription factors during the animal and plant cell cycle /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200836.pdf.

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7

Cheung, Man-sze, and 張敏思. "Investigating the role of FoxM1 in cell cycle progression by inducibleRNA interference." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30396402.

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8

Helton, Eric Scott. "A role for p63 in the regulation of cell cycle progression and cell death." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007p/helton.pdf.

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9

Fahlén, Sara. "Regulation of Myc oncoprotein function by E3 ubiquitin ligases /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200882.pdf.

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10

Wenzel, Pamela L. "Role of the RB-E2F pathway in embryonic development: implications for paradigms of cell cycle control." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1179341665.

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11

Pala, Prashna Jatindra. "Biochemical and biophysical characterisation of the Saccharomyces cerevisiae cell-cycle transcription factors, SBF and MBF." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271258.

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12

Drews-Elger, Katherine. "Role of the transcription factor NFAT5 in mammalian cell cycle regulation." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7177.

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The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the level of the DNA binding domain, and differs from them considerably in other regions. NFAT5 enables mammalian cells to adapt to and withstand hypertonicity by orchestrating an osmoprotective gene expression program whose products include chaperones as well as ransporters and enzymes that increase the intracellular concentration of compatible osmolytes. NFAT5-null mice suffer severe embryonic and

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13

Ho, Yuen. "Proteins physically interacting with the Swi6 cell cycle regulatory transcription factor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0002/NQ41175.pdf.

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14

Almad, Akshata A. "Role Of PPAR Family Of Transcription Factors In Spinal Cord Injury." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1292952253.

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15

Moose, Holly Elizabeth. "Intrinsic Mechanisms Governing Retinal Progenitor Cell Biology: Retinal Homeobox Transcriptional Regulation and the Function of Forkhead Transcription Factors During Eye Development." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1251827616.

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16

Hydbring, Per. "Modulating the activity of the c-Myc oncoprotein : implications for therapeutic treatment /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200907.pdf.

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17

Schaefer, Jonathan Brook. "Regulation of G1 exit by the Swi6p transcription factor /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5080.

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18

Crosby, Meredith Ellen. "E2F4 is a critical molecule involved in the cell cycle arrest reponse following ionizing radiation." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1136934596.

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Thesis (Ph. D.)--Case Western Reserve University, 2006.<br>[School of Medicine] Department of Environmental Health Sciences. Includes bibliographical references. Available online via OhioLINK's ETD Center.

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19

Keasler, Jessica B. "Nuclear Translocation of FoxO3a Transcription Factor During Prelamin A Induced Cell Cycle Arrest in 3T3 Cells." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/honors/133.

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As the so-called “Mothership of the Human Genome,” the cell nucleus must keep all vital genetic information safe, but accessible, inside a strong protective envelope. The inner membrane of the nuclear envelope is lined by tough but adaptable proteins called lamins. While lamins polymerize into fibrous structures that hold up the “walls” of the nucleus, they also serve as an internal scaffold for the complex machinery involved in DNA replication and gene expression. It is in this later role that we have been looking for clues to premature and possibly to normal aging. One type of lamins, Lamin

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20

Skirycz, Aleksandra. "Functional analysis of selected DOF transcription factors in the model plant Arabidopsis thaliana." Phd thesis, Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2008/1698/.

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Transcription factors (TFs) are global regulators of gene expression playing essential roles in almost all biological processes, and are therefore of great scientific and biotechnological interest. This project focused on functional characterisation of three DNA-binding-with-one-zinc-finger (DOF) TFs from the genetic model plant Arabidopsis thaliana, namely OBP1, OBP2 and AtDOF4;2. These genes were selected due to severe growth phenotypes conferred upon their constitutive over-expression. To identify biological processes regulated by OBP1, OBP2 and AtDOF4;2 in detail molecular and physiologi

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21

Freeman, Scott N. "Analysis of E2F1 target genes involved in cell cycle and apoptosis." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002218.

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22

Dutta, Chaitali. "Checkpoint Regulation of S-Phase Transcription: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/391.

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The DNA replication checkpoint transcriptionally up-regulates genes that allow cells to adapt to and survive replication stress. Our results show that, in the fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G1/S transcriptional program by directly regulating MBF (aka DSC1), the G1/S transcription factor. Instead of initiating a checkpoint-specific transcriptional program, the replication checkpoint targets MBF to maintain the normal G1/S transcriptional program during replication stress. We propose a mechanism for this regulation, based on in vitrophosp

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23

Petricca, Stefania [Verfasser], and Ninkovic [Akademischer Betreuer] Jovica. "Transcription factor Pax6 regulates cell cycle progression and cell fate determination : the modular logic of complex transcriptional control / Stefania Petricca. Betreuer: Ninkovic Jovica." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/107885212X/34.

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24

Adkins, Melissa Wess. "The role of histone chaperones in chromatin structure and gene expression /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.

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Thesis (Ph.D. in Biochemistry & Molecular Genetics) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 147-164). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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25

Johnson, Jacqueline Lea. "Matrix Metalloproteinase genes are transcriptionally regulated by E2F transcription factors: a link between cell cycle control and metastatic progression." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4092.

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The RbµE2F transcriptional regulatory pathway plays a critical role in the cell cycle. Rb is inactivated through multiple waves of phosphorylation, mediated mainly by cyclin D and cyclin E associated kinases. Once Rb is inactivated, cells can enter Sµphase. Collectively, three Rb family members and ten E2F proteins coordinate every additional stage of the cell cycle, from quiescence to mitosis. However the RbµE2F pathway is frequently altered in cancer. Aside from cell proliferation, the RbµE2F pathway regulates other essential cellular processes including apoptosis, cell differentiation, angi

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26

Burden, Morwenna J. "The regulation of E2F." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341993.

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27

Gamsby, Joshua John. "Study of the roles of LRBA in cancer cell proliferation and SHIP-1 in NK cell function." [Tampa, Fla] : University of South Florida, 2005. http://purl.fcla.edu/usf/dc/et/SFE0001317.

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28

Fischer, Martin. "The transcription factor p53: not a repressor, solely an activator." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-162026.

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After almost two decades of research on direct repression by p53, I provide evidence that the transcription factor p53 solely acts as an activator of transcription. I evaluate the prominent models of transcriptional regulation by p53 based on a computational meta-analysis of genome-wide data. With this tool at hand, the major contradiction how p53 binding can result in activation of one target gene and repression of another is resolved. In contrast to most current models, solely genes activated by p53 are found to be enriched for p53 binding. Meta-analysis of large-scale data is unable to conf

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29

Dunlop, Allan John. "Structural and functional studies of the DSC1 cell cycle transcription factor complex in fission yeast." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404284.

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30

Davis, Emily. "The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/11890.

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Includes abstract.<br>Includes bibliographical references (leaves 102-131).<br>T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contr

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31

Raven, Jennifer. "Characterization of the roles of the transcription factor Stat1 and the translation initiation factor eIF2alpha kinases in cell cycle control and tumourigenesis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40767.

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The eIF2α kinases PERK and PKR are well characterized regulators of protein synthesis. When they are activated in response to various cellular stresses, they inhibit translation initiation by phosphorylating eIF2α on a key residue. Recently, PKR has been shown to regulate the expression of specific proteins independent of its ability to inhibit protein synthesis, and we wished to identify additional targets of this particular function. The cellular levels of cyclin D1, a cell cycle control protein that regulates progression through G1, decrease under conditions that activate various eIF2α k

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32

Yang, Zhongfa. "The role of GA binding protein (GABP) transcription factor in myeloid differentiation and cell cycle progression /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174701.

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33

Šapošnikov, Dmitrij [Verfasser], Guido Akademischer Betreuer] Posern, Elmar [Akademischer Betreuer] Wahle, and Gunter [Akademischer Betreuer] [Meister. "The role of myocardin-related transcription factors in proliferation and cell cycle regulation of fibroblast cells / Dmitrij Šapošnikov. Betreuer: Guido Posern ; Elmar Wahle ; Gunter Meister." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1038211298/34.

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34

Walldén, Mats. "How precise is cyclic life? : Insights during a single molecule revolution of the bacterial cell cycle." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235546.

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Bacterial cells reproduce by doubling in size and dividing. The molecular control systems which regulate the cell cycle must do so in a manner which maintains a similar cell size over many generations. A cell can under conditions of fast growth conclude cell cycles in shorter time than the time required to replicate its chromosome. Under such conditions several rounds of replication are maintained in parallel and a cell will inherit replication processes which were initiated by an ancestor. To accomplish this the cell has to initiate and terminate one round of replication during each cell cycl

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35

Balakrishnan, Meenakshi Puthucode. "Studies on a novel human cardiospecific transcription factor and its involvement in Omi/HtrA2 mediated cell death." Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4649.

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Omi/HtrA2 is a mitochondrial serine protease that is known to translocate to the cytoplasm upon induction of apoptosis and to activate caspase-dependent and caspase-independent cell death. The molecular mechanism of Omi/HtrA2's function is not clear but involves degradation of specific substrates. These substrates include cytoplasmic, mitochondrial, as well as nuclear proteins. We have pubmedisolated a new Omi/HtrA2 interactor, the THAP5 protein. THAP5 is a fifth member of a large family of transcription factors that are involved in cell proliferation, apoptosis, cell cycle control, chromosome

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36

Chien, Wei Wen. "p16INK4a, régulation du cycle cellulaire et microARN." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10183.

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L’inhibition, par p16INK4a, de la progression du cycle cellulaire est considérée comme liée à un arrêt de la progression en phase G1 du à l’inhibition de l’activité de CDK4/6. Nous montrons que l’expression ectopique de p16INK4a dans trois lignées cellulaires malignes, p16-/- et pRb+/+, issues de tissus différents, provoque un allongement de la durée de la phase S et du cycle cellulaire total. L’ensemble de nos travaux sur p16INK4a sauvage et son mutant p16G101W indique que p16INK4a induit un allongement de la phase S i) indépendamment de l’origine tissulaire des cellules analysées et ii) en p

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37

Salisbury, Rachel. "Gene expression and cell cycle regulation in human pancreas development and congenital hyperinsulinism." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/gene-expression-and-cell-cycle-regulation-in-human-pancreas-development-and-congenital-hyperinsulinism(e9f58d6a-aba4-4179-a683-6d2380a55397).html.

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The dynamics of β-cell mass are at the focus of an extensive international effort to develop β-cell replacement therapies for type 1 diabetes. During normal fetal development endocrine cells emerge from a pool of PDX1+/SOX9+ multipotent progenitors that transiently express the proendocrine gene NGN3. These cells become hormone-positive and are seen to bud from the ductal structures and aggregate into islet clusters. Congenital hyperinsulinism in its diffuse form (CHI-D) is characterised by an increase in hormone-positive cells associated with ducts and diffuse patterns of insulin expression. C

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38

Yao, Haiqin. "Regulation of gametophyte-to-sporophyte transitions during the file cycle of Ectocarpus." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS424.pdf.

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La plupart des organismes eucaryotes se reproduisent sexuellement et ont des cycles de vie qui impliquent une alternance entre les phases haploïde et diploïde en raison de deux processus fondamentaux : la division cellulaire méiotique (à la transition diploïde-haploïde) et la fusion gamète ou syngamie (transition haploïde-diploïde). Dans les organismes photosynthétiques ayant des cycles de vie haploïde-diploïde, ces alternances sont entre deux générations multicellulaires distinctes : gamétophyte et sporophyte. Comme les générations de gamétophytes et de sporophytes sont construites à partir d

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39

Hanschen, Erik R., Tara N. Marriage, Patrick J. Ferris, et al. "The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/614763.

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The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of multicellularity including the initial formation of cooperative cell groups. Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where group formation evolved by co-option of the retinoblastoma cell cycle regulatory pathway. Significantly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes it

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40

Zheng, Gang Gang Zheng. "A molecular 'switchboard' - lysine modifications and their impact on transcription." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1131636831.

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41

Fioravanti, Antonella. "Epigenetic mechanisms and post-translational modifications play a key role in the cell cycle regulation of Alphaproteobacteria." Thesis, Lille 1, 2014. http://www.theses.fr/2014LIL10088/document.

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Chez l’organisme modèle Caulobacter crescentus, de nombreux régulateurs sont impliqués dans le contrôle du cycle cellulaire. Dans ce travail, nous présentons la découverte de l’interaction fonctionnelle entre GcrA et la N6-adenosine méthyltransférase CcrM. La combinaison d’expériences de biochimie, de biophysique, d’immuno-précipitation de la chromatine et de génétique nous a permis de révéler que GcrA est une protéine dimérique qui se fixe à l’ADN, et qui montre une affinité préférentielle, à la fois in vitro et in vivo, pour les promoteurs qui ont été méthylés. Nous avons montré que le compl

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42

Kwok, A. N. P. "A study on the transcription factor Brn-3b, the cell cycle regulation and the cause of elevated Brn-3b expression in cancers." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444488/.

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Cyclin D1, a cell cycle regulator, plays an important role in cell cycle progression. As overexpression of cyclin D1 has been observed in various cancers, it has been considered that high level of cyclin D1 may cause uncontrolled cell proliferation and thus give rise to cancer. Interestingly, we showed that a POU transcription factor Brn-3b, which has been shown to contribute to uncontrolled cell growth and cause tumourigenesis when expressed at a high level, correlates to the level of cyclin D1 mRNA-when the level of Brn-3b mRNA increased, the levels of cyclin D1 mRNA increased when the level

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43

Stephens, Alexandre, and N/A. "Genetic and Functional Characterization of RUNX2." Griffith University. School of Medical Science, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070823.100953.

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RUNX2 belongs to the RUNT domain family of transcription factors of which three have been identified in humans (RUNX1, RUNX2 and RUNX3). RUNX proteins are vital for metazoan development and participate in the regulation of cellular differentiation and cell cycle progression (Coffman, 2003). RUNX2 is required for proper bone formation by driving the differentiation of osteoblasts from mesenchymal progenitors during development (Ducy et al, 1997; Komori et al, 1997; Otto et al, 1997). RUNX2 is also vital for chondrocyte maturation by promoting the differentiation of chondrocytes to the hypertrop

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44

Chen, Hui-Zi. "Mammalian Atypical E2Fs Link Endocycle Control to Cancer." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316540844.

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45

Xenaki, Georgia. "The role of the p300/CBP complex components in the regulation of apoptosis under hypoxia." Thesis, University of Manchester, 2008. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:152382.

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Posttranslational modifications are of great importance in the mediation of transcriptional effects, necessary for signalling in cancer. A characteristic example of such modifications is acetylation of the p53 tumour suppressor, a transcription factor involved in several crucial cellular functions including cell-cycle arrest and apoptosis. p53 is stabilised under hypoxic and DNA damaging-conditions. However, only in the latter scenario is p53 fully capable of inducing the expression of its proapoptotic targets through acetylation. The hypoxia inducible factor 1 (HIF-1) transcription factor is

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46

Rogoff, Harry A. "Pathways Linking Deregulated Proliferation to Apoptosis: a Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/63.

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Proper regulation of cellular proliferation is critical for normal development and cancer prevention. Most, if not all, cancers contain mutations in the Rb/E2F pathway, which controls cellular proliferation. Inactivation of the retinoblastoma protein (Rb) can occur through Rb loss, mutation, or inactivation by cellular or viral oncoproteins leading to unrestrained proliferation. This occurs primarily by de-repression and activation of the E2F transcription factors, which promote the transition of cells from the G1to S phase of the cell cycle. In order to protect against loss of growth control,

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47

Gómez, Escoda Blanca. "Max1 links MBF dependent transcription upon completion of DNA synthesis in fission yeast." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7223.

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When DNA replication is challenged, cells activate a DNA synthesis checkpoint blocking cell cycle progression until they are able to overcome the replication defects. In fission yeast, Cds1 is the effector kinase of this checkpoint, inhibiting M phase entry, stabilizing stalled replication forks and triggering transcriptional activation of S-phase genes; the molecular basis of this last effect remains largely unknown. The MBF complex controls the transcription of S-phase genes. We have purified novel interactors of the MBF complex and among them we have identified the repressor Max1. When the

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48

Bensimon, Maharaj Victoria. "Novel Cell Cycle Regulation of the Transcription Factor p53 and the Kinase c-Abl in Skeletal Myoblast Cultured in Differentiation Media and the Fusion of Myoblasts." Cleveland State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=csu1600275796611256.

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49

Ivanova, Tsvetomira Georgieva 1978. "The DNA damage and the DNA synthesis checkpoints converge at the MBF transcription factor." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/116932.

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DNA damage is an ongoing threat to both the ability of the cell to faithfully transmit genetic information to its offspring as well as to its own survival. In order to maintain genomic integrity, eukaryotes have developed a highly conserved mechanism to detect, signal and repair damage in DNA, known as the DNA damage response (DDR). In fission yeast the two DDR pathways converge at the regulation of single transcriptional factor complex (MBF) resulting in opposite directions. We have shown that when the DNA-synthesis checkpoint is activated, Max1 is phosphorylated by Cds1 resulting in the abro

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50

Dimitrov, Vassil. "The cancer chemo-preventive properties of vitamin D are due, at least in part, to the transcriptional regulation of genes implicated in cell cycle, DNA replication and Apoptosis, and activation of FoxO3a transcription factor." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107691.

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Vitamin D is produced in the skin or obtained from limited dietary sources. Two sequential hydroxylation reactions in the liver and kidney produce the active form of the hormone, 1,25-(OH)2D3, which binds to and activates VDR to regulate gene expression (genomic effects) or to VDRmem or MARRS to trigger certain signalling pathways (non-genomic effects). 1,25-(OH)2D3 is best known for its effects on calcium and phosphate metabolism, but it also possesses chemopreventive properties for many types of cancers, particularly those of the digestive tract.The anti-proliferative effects of 1,25-(OH)2D3

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