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Journal articles on the topic 'Cell fat plasticity'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Casteilla, Louis, Béatrice Cousin, and Mamen Carmona. "PPARs and Adipose Cell Plasticity." PPAR Research 2007 (2007): 1–7. http://dx.doi.org/10.1155/2007/68202.

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Due to the importance of fat tissues in both energy balance and in the associated disorders arising when such balance is not maintained, adipocyte differentiation has been extensively investigated in order to control and inhibit the enlargement of white adipose tissue. The ability of a cell to undergo adipocyte differentiation is one particular feature of all mesenchymal cells. Up until now, the peroxysome proliferator-activated receptor (PPAR) subtypes appear to be the keys and essential players capable of inducing and controlling adipocyte differentiation. In addition, it is now accepted tha

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Olson, Lorin E., та Philippe Soriano. "PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development". Developmental Cell 20, № 6 (2011): 815–26. http://dx.doi.org/10.1016/j.devcel.2011.04.019.

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Bielczyk-Maczynska, Ewa. "White Adipocyte Plasticity in Physiology and Disease." Cells 8, no. 12 (2019): 1507. http://dx.doi.org/10.3390/cells8121507.

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Cellular plasticity is a transformation of a terminally differentiated cell into another cell type, which has been long known to occur in disease and regeneration. However, white adipocytes (fat cells) have only recently been observed to undergo different types of cellular plasticity. Adipocyte transdifferentiation into myofibroblasts and cancer-associated fibroblasts occurs in fibrosis and cancer, respectively. On the other hand, reversible adipocyte dedifferentiation into adipocyte progenitor cells (preadipocytes) has been demonstrated in mammary gland and in dermal adipose tissue. Here we d

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MOULIN, Karine, Nathalie TRUEL, Mireille ANDRÉ, et al. "Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype." Biochemical Journal 356, no. 2 (2001): 659–64. http://dx.doi.org/10.1042/bj3560659.

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In mammals, two types of adipose tissue are present, brown and white. They develop sequentially, as brown fat occurs during late gestation whereas white fat grows mainly after birth. However, both tissues have been shown to have great plasticity. Thus an apparent transformation of brown fat into white fat takes place during post-natal development. This observation raises questions about a possible conversion of brown into white adipocytes during development, although indirect data argue against this hypothesis. To investigate such questions in vivo, we generated two types of transgenic line. T

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Herzog, Erica L., Li Chai, and Diane S. Krause. "Plasticity of marrow-derived stem cells." Blood 102, no. 10 (2003): 3483–93. http://dx.doi.org/10.1182/blood-2003-05-1664.

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AbstractBone marrow (BM) contains hematopoietic stem cells (HSCs), which differentiate into every type of mature blood cell; endothelial cell progenitors; and marrow stromal cells, also called mesenchymal stem cells (MSCs), which can differentiate into mature cells of multiple mesenchymal tissues including fat, bone, and cartilage. Recent findings indicate that adult BM also contains cells that can differentiate into additional mature, nonhematopoietic cells of multiple tissues including epithelial cells of the liver, kidney, lung, skin, gastrointestinal (GI) tract, and myocytes of heart and s

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Linehan, Victoria, Lisa Z. Fang, Matthew P. Parsons, and Michiru Hirasawa. "High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus." Molecular Metabolism 36 (June 2020): 100977. http://dx.doi.org/10.1016/j.molmet.2020.100977.

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De Fano, Michelatonio, Desirèe Bartolini, Cristina Tortoioli, et al. "Adipose Tissue Plasticity in Response to Pathophysiological Cues: A Connecting Link between Obesity and Its Associated Comorbidities." International Journal of Molecular Sciences 23, no. 10 (2022): 5511. http://dx.doi.org/10.3390/ijms23105511.

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Adipose tissue (AT) is a remarkably plastic and active organ with functional pleiotropism and high remodeling capacity. Although the expansion of fat mass, by definition, represents the hallmark of obesity, the dysregulation of the adipose organ emerges as the forefront of the link between adiposity and its associated metabolic and cardiovascular complications. The dysfunctional fat displays distinct biological signatures, which include enlarged fat cells, low-grade inflammation, impaired redox homeostasis, and cellular senescence. While these events are orchestrated in a cell-type, context-de

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Rabhi, Nabil, and Stephen R. Farmer. "Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies." Genes & Development 35, no. 21-22 (2021): 1395–97. http://dx.doi.org/10.1101/gad.349053.121.

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Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed thermogenic beige adipocytes within white depots in response to catecholamines secretion. Coordinated cellular interaction between different cell types within the tissue and a fine-tuned transcriptional program synergistically take place to promote beige remodeling. However, both cell–cell interactio

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Petan, Toni, Eva Jarc, and Maida Jusović. "Lipid Droplets in Cancer: Guardians of Fat in a Stressful World." Molecules 23, no. 8 (2018): 1941. http://dx.doi.org/10.3390/molecules23081941.

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Cancer cells possess remarkable abilities to adapt to adverse environmental conditions. Their survival during severe nutrient and oxidative stress depends on their capacity to acquire extracellular lipids and the plasticity of their mechanisms for intracellular lipid synthesis, mobilisation, and recycling. Lipid droplets, cytosolic fat storage organelles present in most cells from yeast to men, are emerging as major regulators of lipid metabolism, trafficking, and signalling in various cells and tissues exposed to stress. Their biogenesis is induced by nutrient and oxidative stress and they ac

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Baragetti, Andrea, and Giuseppe Danilo Norata. "The High Fat Diet Impacts the Plasticity between Fresh and Aged Neutrophils." Journal of Cellular Immunology 5, no. 5 (2023): 168–73. http://dx.doi.org/10.33696/immunology.5.182.

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Metabolic alterations induced by unhealthy lifestyles, including obesity and insulin resistance are often associated with increased innate immune response and chronic inflammation. Cholesterol has been identified as a key metabolite driving the activation of the inflammasome and the “epigenetic memory” in long-term living hematopoietic stem cells. In addition to these mechanisms, the physiological aging of short-living neutrophils is a relevant modifier of their immune competency, as while they egress from medullary niches as “fresh”, fully competent, cells, they turn into “aged”, disarmed cel

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Natale, Francesca, Matteo Spinelli, Saviana Antonella Barbati, Lucia Leone, Salvatore Fusco, and Claudio Grassi. "High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms." Cells 11, no. 17 (2022): 2661. http://dx.doi.org/10.3390/cells11172661.

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Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2HFD and F3HFD). Maternal HFD caused a multigenera

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Shuo, Wang, Haicong Li, Nishijo Muneko, et al. "Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression." Journal of International Medical Research 48, no. 11 (2020): 030006052096401. http://dx.doi.org/10.1177/0300060520964016.

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Objective Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene ( ApoE) is a robust risk factor for progression of Alzheimer’s disease. A fatty diet is considered detrimental for metabolic disorders, such as obesity and cardiovascular diseases. Methods We examined the neuronal and cardiac protective roles of RCAN1 in ApoE−/− mice that were fed a high- or low-fat diet with and without voluntary movement for 3 mo

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Rosell, Meritxell, Myrsini Kaforou, Andrea Frontini, et al. "Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice." American Journal of Physiology-Endocrinology and Metabolism 306, no. 8 (2014): E945—E964. http://dx.doi.org/10.1152/ajpendo.00473.2013.

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Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site. We explored the plasticity of different white adipose tissue depots in acquiring a brown phenotype by cold exposure. By comparing cold-induced genes in white fat to those enriched in brown compared with white fat, at thermoneutrality we defined a “brite” transcription signature. We identified the genes, pathways, and promoter regulatory motifs associated with “browning,” as these represent novel targets for understanding this process. For example, neuregulin 4 was more highly expressed in brown adipose tiss

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Rusli, Fenni, Mark V. Boekschoten, Vincenzo Borelli, et al. "Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age." Aging Cell 17, no. 2 (2017): e12696. http://dx.doi.org/10.1111/acel.12696.

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Tchkonia, Tamara, Yourka D. Tchoukalova, Nino Giorgadze, et al. "Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots." American Journal of Physiology-Endocrinology and Metabolism 288, no. 1 (2005): E267—E277. http://dx.doi.org/10.1152/ajpendo.00265.2004.

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Fat depots vary in function and size. The preadipocytes that fat cells develop from exhibit distinct regional characteristics that persist in culture. Human abdominal subcutaneous cultured preadipocytes undergo more extensive lipid accumulation, higher adipogenic transcription factor expression, and less TNF-α-induced apoptosis than omental preadipocytes. We found higher replicative potential in subcutaneous and mesenteric than in omental preadipocytes. In studies of colonies arising from single preadipocytes, two preadipocyte subtypes were found, one capable of more extensive replication, dif

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Shatova, Olga P., Anastasia A. Zabolotneva, Mikhail B. Potievskiy, Aleksandr V. Shestopalov, and Sergei A. Roumiantsev. "Milestones in Molecular Mechanisms of Adipogenesis and Adipose Tissue Plasticity." International Journal of Biomedicine 11, no. 3 (2021): 323–32. http://dx.doi.org/10.21103/article11(3)_ra3.

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This review focuses on the problem of adipogenesis mechanisms and the biological role of adipose tissue (AT) in the human body. Over the past decades, various types of adipocytes have been identified and characterized—white, brown, beige, yellow, and pink. An important feature of AT is a high plasticity and the ability to transdifferentiate and de-differentiate into another cell type. In this case, the pathway of transformation mostly depends on adipocytes’ cellular and metabolic microenvironment. The mechanisms of adipogenesis and the ways of its regulation remain not fully understood. The pr

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Bräunig, P., W. G. Glanzner, V. B. Rissi, and P. B. D. Gonçalves. "The differentiation potential of adipose tissue-derived mesenchymal stem cells into cell lineage related to male germ cells." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 70, no. 1 (2018): 160–68. http://dx.doi.org/10.1590/1678-4162-9132.

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ABSTRACT The adipose tissue is a reliable source of Mesenchymal stem cells (MSCs) showing a higher plasticity and transdifferentiation potential into multilineage cells. In the present study, adipose tissue-derived mesenchymal stem cells (AT-MSCs) were isolated from mice omentum and epididymis fat depots. The AT-MSCs were initially compared based on stem cell surface markers and on the mesodermal trilineage differentiation potential. Additionally, AT-MSCs, from both sources, were cultured with differentiation media containing retinoic acid (RA) and/or testicular cell-conditioned medium (TCC).

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Spinelli, Matteo, Francesca Natale, Marco Rinaudo, et al. "Neural Stem Cell-Derived Exosomes Revert HFD-Dependent Memory Impairment via CREB-BDNF Signalling." International Journal of Molecular Sciences 21, no. 23 (2020): 8994. http://dx.doi.org/10.3390/ijms21238994.

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Overnutrition and metabolic disorders impair cognitive functions through molecular mechanisms still poorly understood. In mice fed with a high fat diet (HFD) we analysed the expression of synaptic plasticity-related genes and the activation of cAMP response element-binding protein (CREB)-brain-derived neurotrophic factor (BDNF)-tropomyosin receptor kinase B (TrkB) signalling. We found that a HFD inhibited both CREB phosphorylation and the expression of a set of CREB target genes in the hippocampus. The intranasal administration of neural stem cell (NSC)-derived exosomes (exo-NSC) epigeneticall

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Giordano, Antonio, Arianna Smorlesi, Andrea Frontini, Giorgio Barbatelli, and Saverio Cinti. "MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ." European Journal of Endocrinology 170, no. 5 (2014): R159—R171. http://dx.doi.org/10.1530/eje-13-0945.

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In mammals, adipocytes are lipid-laden cells making up the parenchyma of the multi-depot adipose organ. White adipocytes store lipids for release as free fatty acids during fasting periods; brown adipocytes burn glucose and lipids to maintain thermal homeostasis. A third type of adipocyte, the pink adipocyte, has recently been characterised in mouse subcutaneous fat depots during pregnancy and lactation. Pink adipocytes are mammary gland alveolar epithelial cells whose role is to produce and secrete milk. Emerging evidence suggests that they derive from the transdifferentiation of subcutaneous

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Song, Tongxing, and Shihuan Kuang. "Adipocyte dedifferentiation in health and diseases." Clinical Science 133, no. 20 (2019): 2107–19. http://dx.doi.org/10.1042/cs20190128.

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Abstract Adipose tissues collectively as an endocrine organ and energy storage are crucial for systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or fat cells, are remarkably plastic and can increase or decrease their size and number to adapt to changes in systemic or local metabolism. Changes in adipocyte size occur through hypertrophy or atrophy, and changes in cell numbers mainly involve de novo generation of new cells or death of existing cells. Recently, dedifferentiation, whereby a mature adipocyte is reverted to an undifferentiated progenitor-like

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Lee, Carlin, Meng Yao Liu, C. Benjamin Ma, Xuhui Liu, and Brian Feeley. "Inducible endogenous stem cells within human rotator cuff muscle to promote muscle regeneration after rotator cuff repair." Orthopaedic Journal of Sports Medicine 8, no. 7_suppl6 (2020): 2325967120S0033. http://dx.doi.org/10.1177/2325967120s00332.

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Objectives: Rotator cuff (RC) tears are the most common upper extremity injury, with over two million Americans seeking medical attention annually. Secondary muscle degradation following RC tears, including atrophy and fatty infiltration (FI), are critical factors that directly determine the clinical outcome of patients with this injury In mouse studies, the importance of fibro/adipogenic (FAP) cells in the development of FI after RC tears has been shown, determining that these cells are the predominant cell line responsible for the development of FI. FAP cells have garnered considerable inter

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Yu, I.-Chen Ivorine, Hallel C. Paraiso, Ping-Chang Kuo, Barbara A. Scofield, Fen-Lei Chang, and Jui-Hung Yen. "Single-cell transcriptome analysis reveals CNS innate immune landscape plasticity in diet-induced obesity and type 2 diabetes." Journal of Immunology 206, no. 1_Supplement (2021): 111.11. http://dx.doi.org/10.4049/jimmunol.206.supp.111.11.

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Abstract Midlife obesity and type 2 diabetes are strong risk factors for late-life cognitive impairment and dementia. Previous studies show that obesity is associated with a heightened state of neuroinflammation, indicating that systemic factors profoundly influence brain innate immunity. Here, we reported that the diversity and plasticity of brain myeloid cells are reshaped in middle-aged mice fed with a high-fat diet (HFD). Using single-cell RNA sequencing, we revealed the heterogeneity of brain-resident myeloid cells, including microglia (MG, Tmem119/P2ry12/Hexb) and border-associated macro

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Cousin, B., S. Cinti, M. Morroni, et al. "Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization." Journal of Cell Science 103, no. 4 (1992): 931–42. http://dx.doi.org/10.1242/jcs.103.4.931.

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Brown adipocytes are thermogenic cells which play an important role in energy balance. Their thermogenic activity is due to the presence of a mitochondrial uncoupling protein (UCP). Until recently, it was admitted that in rodents brown adipocytes were mainly located in classical brown adipose tissue (BAT). In the present study, we have investigated the presence of UCP protein or mRNA in white adipose tissue (WAT) of rats. Using polymerase chain reaction or Northern blot hybridization, UCP mRNA was detected in mesenteric, epidydimal, retroperitoneal, inguinal and particularly in periovarian adi

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Romo-Araiza, Alejandra, Rocío I. Picazo-Aguilar, Ernesto Griego, et al. "Symbiotic Supplementation (E. faecium and Agave Inulin) Improves Spatial Memory and Increases Plasticity in the Hippocampus of Obese Rats: A Proof-of-Concept Study." Cell Transplantation 32 (January 2023): 096368972311773. http://dx.doi.org/10.1177/09636897231177357.

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Obesity has been linked to cognitive impairment through systemic low-grade inflammation. High fat and sugar diets (HFSDs) also induce systemic inflammation, either by induced Toll-like receptor 4 response, or by causing dysbiosis. This study aimed to evaluate the effect of symbiotics supplementation on spatial and working memory, butyrate concentration, neurogenesis, and electrophysiological recovery of HFSD-fed rats. In a first experiment, Sprague-Dawley male rats were given HFSD for 10 weeks, after which they were randomized into 2 groups ( n = 10 per group): water (control), or Enterococcus

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Takchi, Andrew, and Antonino Bonaventura D'assoro. "Effect of AURKA targeting on nuclear PD-L1 and the efficacy of immune checkpoint inhibitors in triple-negative breast cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e13153-e13153. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13153.

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e13153 Background: Aurora-A mitotic kinase (AURKA) plays a role in Triple Negative Breast Cancer (TNBC) progression through activation of epithelial to mesenchymal transition (EMT)-mediated cancer cell plasticity. Cancer cells that undergo EMT acquire a CD44high/CD24low and/or ALDHhigh cancer stem-like phenotype (Cancer Stem Cells) characterized by intrinsic drug resistance. Cancer Stem Cells (CSCs) shows high PD-L1 expression that induces tumor immune escape through CD8+ T-cells exhaustion. Significantly, “undraggable” nuclear PD-L1 may play a key role in induction of immune therapy resistanc

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Comstock, Sarah M., Lynley D. Pound, Jacalyn M. Bishop та ін. "High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate". Molecular Metabolism 2, № 1 (2013): 10–22. http://dx.doi.org/10.1016/j.molmet.2012.11.001.

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Wang, Qiong (Annabel). "AGING-RELATED ADIPOSE REMODELING AND DYSFUNCTION." Innovation in Aging 6, Supplement_1 (2022): 320. http://dx.doi.org/10.1093/geroni/igac059.1262.

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Abstract Aging is associated with insulin resistance, cardiovascular dysfunction, and many other chronic metabolic disorders, significantly shortening healthspan and lifespan. Fat (adipose) tissue, as the major site for energy storage, maintains whole-body energy homeostasis and insulin sensitivity. Adipose tissue has extraordinary plasticity, and it was not until recently that fat tissue remodeling during aging is considered to play an essential role in aging-associated metabolic disorders. Benefiting from recent technology advances, especially the single-cell technology and comprehensive gen

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Theobalt, Natalie, Isabel Hofmann, Sonja Fiedler, et al. "Unbiased analysis of obesity related, fat depot specific changes of adipocyte volumes and numbers using light sheet fluorescence microscopy." PLOS ONE 16, no. 3 (2021): e0248594. http://dx.doi.org/10.1371/journal.pone.0248594.

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In translational obesity research, objective assessment of adipocyte sizes and numbers is essential to characterize histomorphological alterations linked to obesity, and to evaluate the efficacies of experimental medicinal or dietetic interventions. Design-based quantitative stereological techniques based on the analysis of 2D-histological sections provide unbiased estimates of relevant 3D-parameters of adipocyte morphology, but often involve complex and time-consuming tissue processing and analysis steps. Here we report the application of direct 3D light sheet fluorescence microscopy (LSFM) f

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Deugnier, Marie-Ange, Marisa M. Faraldo, Bassam Janji, Patricia Rousselle, Jean Paul Thiery, and Marina A. Glukhova. "EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties." Journal of Cell Biology 159, no. 3 (2002): 453–63. http://dx.doi.org/10.1083/jcb.200207138.

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The bilayered mammary epithelium comprises a luminal layer of secretory cells and a basal layer of myoepithelial cells. Numerous data suggest the existence of self-renewing, pluripotent mammary stem cells; however, their molecular characteristics and differentiation pathways are largely unknown. BC44 mammary epithelial cells in culture, display phenotypic characteristics of basal epithelium, i.e., express basal cytokeratins 5 and 14 and P-cadherin, but no smooth muscle markers. In vivo, after injection into the cleared mammary fat pad, these cells gave rise to bilayered, hollow, alveolus-like

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Natale, Francesca, Lucia Leone, Marco Rinaudo, et al. "Neural Stem Cell-Derived Extracellular Vesicles Counteract Insulin Resistance-Induced Senescence of Neurogenic Niche." Stem Cells 40, no. 3 (2022): 318–31. http://dx.doi.org/10.1093/stmcls/sxab026.

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Abstract Neural stem and progenitor cell (NSPC) depletion may play a crucial role in the cognitive impairment observed in many age-related non-communicable diseases. Insulin resistance affects brain functions through a plethora of mechanisms that remain poorly understood. In an experimental model of insulin resistant NSPCs, we identified a novel molecular circuit relying on insulin receptor substrate-1 (IRS-1)/ Forkhead box O (FoxO) signaling cascade and inhibiting the recruitment of transcription factors FoxO1 and FoxO3a on the promoters of genes regulating proliferation and self-renewal. Ins

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Lupien, Leslie E., Katarzyna Bloch, Jonas Dehairs, et al. "Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells." Journal of Lipid Research 61, no. 2 (2019): 205–18. http://dx.doi.org/10.1194/jlr.ra119000327.

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We previously described the expression of CD36 and LPL by breast cancer (BC) cells and tissues and the growth-promoting effect of VLDL observed only in the presence of LPL. We now report a model in which LPL is bound to a heparan sulfate proteoglycan motif on the BC cell surface and acts in concert with the VLDL receptor to internalize VLDLs via receptor-mediated endocytosis. We also demonstrate that gene-expression programs for lipid synthesis versus uptake respond robustly to triglyceride-rich lipoprotein availability. The literature emphasizes de novo FA synthesis and exogenous free FA upta

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Chamas, Lamis, Isabelle Seugnet, Roseline Poirier, Marie-Stéphanie Clerget-Froidevaux, and Valérie Enderlin. "A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation." International Journal of Molecular Sciences 23, no. 19 (2022): 11938. http://dx.doi.org/10.3390/ijms231911938.

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Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in synaptic plasticity. Local reduced levels of thyroid hormones (THs) may impair glia morphology and activity, and promote the increase of pro-inflammatory cytokine levels mainly in the hippocampus. Given that neuroinflammation induces memory impairments, hypothyroidism-related glia dysfunction may participate in brain disorders. Thus, we investigated the mechanisms linking hypothyroidism and neuroinflammation, from a protective perspective. We induced hypothyroidism in adult

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O’Hara, Stephanie E., Kelly M. Gembus, and Lisa M. Nicholas. "Understanding the Long-Lasting Effects of Fetal Nutrient Restriction versus Exposure to an Obesogenic Diet on Islet-Cell Mass and Function." Metabolites 11, no. 8 (2021): 514. http://dx.doi.org/10.3390/metabo11080514.

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Early life represents a window of phenotypic plasticity. Thus, exposure of the developing fetus to a compromised nutritional environment can have long term consequences for their health. Indeed, undernutrition or maternal intake of an obesogenic diet during pregnancy leads to a heightened risk of type 2 diabetes (T2D) and obesity in her offspring in adult life. Given that abnormalities in beta-cell function are crucial in delineating the risk of T2D, studies have investigated the impact of these exposures on islet morphology and beta-cell function in the offspring in a bid to understand why th

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Qu, Guanlin, Yan Li, Lu Chen, et al. "Comparison of Osteogenic Differentiation Potential of Human Dental-Derived Stem Cells Isolated from Dental Pulp, Periodontal Ligament, Dental Follicle, and Alveolar Bone." Stem Cells International 2021 (April 7, 2021): 1–12. http://dx.doi.org/10.1155/2021/6631905.

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Background. Mesenchymal stem cells (MSCs) have become promising candidates for regeneration medicine due to their multidifferentiation potential and immunomodulatory ability. Compared with classic MSCs derived from the bone marrow and fat, dental-derived MSCs show high plasticity, accessibility, and applicability. Therefore, they are considered alternative sources for regeneration medicine. Methods. Four types of MSCs were isolated from the dental pulp, periodontal ligament, dental follicle, and alveolar bone of the same donor, and there were five different individuals. We analyzed their morph

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Ramanathan, Mrunalini, Md Mahbobur Rahman, Ankhtsetseg Shijirbold, et al. "Evaluation of Outgrowth Potential of Rat Pheochromocytoma Cells Supplied with Highly Purified Rapidly Expanding Clones and Potential Application to Trigeminal Nerve Regeneration." NeuroSci 6, no. 2 (2025): 39. https://doi.org/10.3390/neurosci6020039.

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Background:Mesenchymal stem/stromal cells (MSCs) are non-hematopoietic, plastic-adherent, and self-renewing cells capable of in vitro trilineage differentiation into fat, bone, and cartilage tissue. Suggestively, MSCs have additional plasticity, as demonstrated by their ability to differentiate in vitro into myocytes, neuron-like cells, and hepatocytes. MSCs are ideal for therapeutic application owing to their numerous advantages; they exhibit limited growth and differentiation abilities, leading to heterogeneous cell populations with inconsistent functions. However, highly purified MSCs, name

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D'Assoro, Antonino Bonaventura, Matthew Goetz, Carol Lange, et al. "Abstract 5978: Pharmacological blockade of AURKA and NOTCH3 oncogenic pathways to inhibit cancer cell plasticity in triple negative breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 5978. https://doi.org/10.1158/1538-7445.am2025-5978.

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Abstract Background: Despite recent advances in the treatment of triple negative breast cancer (TNBC) many patients are still suffering from early recurrence, therapy resistance, and organ metastasis 1 to 3 years post-chemotherapy. TNBC cells with stem cell-like properties are resistant to standard of care chemotherapy and are responsible for early tumor relapse and poor outcome. Up-regulation of PD-L1 expression in Cancer Stem Cells (CSCs) has been associated with immune evasion capacity and promotion of their stem-like properties. In this study we identify two druggable stemness target, Auro

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Conese, Massimo, Luigi Annacontini, Annalucia Carbone, et al. "The Role of Adipose-Derived Stem Cells, Dermal Regenerative Templates, and Platelet-Rich Plasma in Tissue Engineering-Based Treatments of Chronic Skin Wounds." Stem Cells International 2020 (January 9, 2020): 1–17. http://dx.doi.org/10.1155/2020/7056261.

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The continuous improvements in the field of both regenerative medicine and tissue engineering have allowed the design of new and more efficacious strategies for the treatment of chronic or hard-to-heal skin wounds, which represent heavy burden, from a medical and economic point of view. These novel approaches are based on the usage of three key methodologies: stem cells, growth factors, and biomimetic scaffolds. These days, the adipose tissue can be considered the main source of multipotent mesenchymal stem cells, especially adipose-derived stem cells (ASCs). ASCs are easily accessible from va

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Hemnes, Anna R., Joshua P. Fessel, Xinping Chen, et al. "BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes." American Journal of Physiology-Lung Cellular and Molecular Physiology 318, no. 2 (2020): L429—L441. http://dx.doi.org/10.1152/ajplung.00555.2018.

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Insulin resistance and right ventricular (RV) dysfunction are associated with lipotoxicity in heritable forms of pulmonary arterial hypertension (PAH), commonly due to mutations in bone morphogenetic protein receptor type 2 (BMPR2). How BMPR2 dysfunction in cardiomyocytes alters glucose metabolism and the response of these cells to insulin are unknown. We hypothesized that BMPR2 mutation in cardiomyocytes alters glucose-supported mitochondrial respiration and impairs cellular responses to insulin, including glucose and lipid uptake. We performed metabolic assays, immunofluorescence and Western

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Takchi, Andrew, and Tufia C. Haddad. "Effect of DUAL pharmacological blockade of AURKA and PD-L1 pathways on plasticity and metastasis for triple negative breast cancer." Journal of Clinical Oncology 41, no. 16_suppl (2023): e13100-e13100. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e13100.

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e13100 Background: Aurora-A mitotic kinase (AURKA) plays a pivotal role in Triple Negative Breast Cancer (TNBC) progression through activation of epithelial to mesenchymal transition (EMT)-mediated cancer cell plasticity. Cancer cells that undergo EMT acquire a CD44high/CD24low and/or ALDHhigh cancer stem-like phenotype (Cancer Stem Cells) characterized by high self-renewal capacity and intrinsic drug resistance. Cancer Stem Cells (CSCs) also shows high PD-L1 expression that plays a critical role in inducing tumor immune escape through CD8+ T-cells exhaustion. For these reasons, molecular char

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Shi, Yunpeng, Chengrui Nan, Zhongjie Yan, et al. "Synaptic Plasticity of Human Umbilical Cord Mesenchymal Stem Cell Differentiating into Neuron-like Cells In Vitro Induced by Edaravone." Stem Cells International 2018 (October 28, 2018): 1–11. http://dx.doi.org/10.1155/2018/5304279.

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Objective. The human umbilical cord mesenchymal stem cells (hUMSCs) are characterized with the potential ability to differentiate to several types of cells. Edaravone has been demonstrated to prevent the hUMSCs from the oxidative damage, especially its ability in antioxidative stress. We hypothesized that Edaravone induces the hUMSCs into the neuron-like cells. Methods. The hUMSCs were obtained from the human umbilical cord tissue. The differentiation of hUMSCs was induced by Edaravone with three different doses: 0.65 mg/ml, 1.31 mg/ml, and 2.62 mg/ml. Flow cytometry was used to detect the cel

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Boufaied, Nadia, Paolo Chetta, Tarek Hallal, et al. "Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer." Cancer Research 84, no. 11 (2024): 1834–55. http://dx.doi.org/10.1158/0008-5472.can-23-0519.

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Abstract Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment (TME) and drive cancer could facilitate development of precision nutrition approaches. Using the Hi-MYC prostate cancer mouse model, we demonstrated that an obesogenic high-fat diet (HFD) rich in saturated fats accelerates the development of c-MYC–driven invasive prostate cancer through metabolic rewiring. Although c-MYC modulated key me

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Ruzhytska, O. V., A. R. Kucher, V. Yu Vovk, et al. "Clinical and Sonographic Analysis of Biometric Indicators of Cheek Thickness and Cheek Fat Body in Patients with Different Face Types." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 6 (2021): 177–82. http://dx.doi.org/10.26693/jmbs06.06.177.

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The purpose of the study was to conduct a scientific and practical analysis of clinical sonographic results of examination of patients with different face types in the process of planning the reconstruction of facial soft tissues with the involvement of buccal fat pad. Materials and methods. The study was conducted on 28 patients of different age groups (from 20 to 45 years old) with defects and deformities of the tissues of the dental system. Instrumental sonographic analysis of the thickness of the buccal fat body was performed using an ultrasound scanner GE Logiq E (USA), transducer frequen

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Gong, Pengfei, Danielle Bailbé, Lola Bianchi, et al. "Paternal High-Protein Diet Programs Offspring Insulin Sensitivity in a Sex-Specific Manner." Biomolecules 11, no. 5 (2021): 751. http://dx.doi.org/10.3390/biom11050751.

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The impact of maternal nutrition on offspring is well documented. However, the implication of pre-conceptional paternal nutrition on the metabolic health of the progeny remains underexplored. Here, we investigated the impact of paternal high-protein diet (HPD, 43.2% protein) consumption on the endocrine pancreas and the metabolic phenotype of offspring. Male Wistar rats were given HPD or standard diet (SD, 18.9% protein) for two months. The progenies (F1) were studied at fetal stage and in adulthood. Body weight, glycemia, glucose tolerance (GT), glucose-induced insulin secretion in vivo (GIIS

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Vettor, Roberto, Gabriella Milan, Chiara Franzin, et al. "The origin of intermuscular adipose tissue and its pathophysiological implications." American Journal of Physiology-Endocrinology and Metabolism 297, no. 5 (2009): E987—E998. http://dx.doi.org/10.1152/ajpendo.00229.2009.

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The intermuscular adipose tissue (IMAT) is a depot of adipocytes located between muscle bundles. Several investigations have recently been carried out to define the phenotype, the functional characteristics, and the origin of the adipocytes present in this depot. Among the different mechanisms that could be responsible for the accumulation of fat in this site, the dysdifferentiation of muscle-derived stem cells or other mesenchymal progenitors has been postulated, turning them into cells with an adipocyte phenotype. In particular, muscle satellite cells (SCs), a heterogeneous stem cell populat

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Perruchot, Marie-Hélène, Louis Lefaucheur, Corinne Barreau, Louis Casteilla, and Isabelle Louveau. "Age-related changes in the features of porcine adult stem cells isolated from adipose tissue and skeletal muscle." American Journal of Physiology-Cell Physiology 305, no. 7 (2013): C728—C738. http://dx.doi.org/10.1152/ajpcell.00151.2013.

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A better understanding of the control of body fat distribution and muscle development is of the upmost importance for both human and animal physiology. This requires a better knowledge of the features and physiology of adult stem cells in adipose tissue and skeletal muscle. Thus the objective of the current study was to determine the type and proportion of these cells in growing and adult pigs. The different cell subsets of stromal vascular cells isolated from these tissues were characterized by flow cytometry using cell surface markers (CD11b, CD14, CD31, CD34, CD45, CD56, and CD90). Adipose

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Xu, Xi, Yang Lin, Shalini Bahl, and Mathieu Lupien. "Abstract 1543: Obesity promotes triple negative breast cancer progression through regulating the plasticity of adipose tissue." Cancer Research 85, no. 8_Supplement_1 (2025): 1543. https://doi.org/10.1158/1538-7445.am2025-1543.

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Abstract The rising global prevalence of overweight and obesity is linked to cancer initiation and poorer overall survival in triple-negative breast cancer (TNBC), making it a modifiable risk factor for both cancer prevention and treatment. The tumor microenvironment (TME) plays a crucial role in tumor development, progression, and response to chemotherapy, and is influenced by both local and systemic factors, such as aging and metabolism. However, most previous studies in this area have relied on animal models or in vitro systems, which provide limited insights into the comprehensive nature o

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Cavaliere, Gina, Angela Catapano, Giovanna Trinchese, et al. "Butyrate Improves Neuroinflammation and Mitochondrial Impairment in Cerebral Cortex and Synaptic Fraction in an Animal Model of Diet-Induced Obesity." Antioxidants 12, no. 1 (2022): 4. http://dx.doi.org/10.3390/antiox12010004.

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Neurodegenerative diseases (NDDs) are characterized by cognitive impairment and behavioural abnormalities. The incidence of NDDs in recent years has increased globally and the pathological mechanism is not fully understood. To date, plentiful evidence has showed that metabolic alterations associated with obesity and related issues such as neuroinflammation, oxidative stress and mitochondrial dysfunction may represent an important risk factor, linking obesity and NDDs. Numerous studies have indicated a correlation between diet and brain activities. In this context, a key role is played by mitoc

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Hügle, Thomas, Jeroen Geurts, Corina Nüesch, Magdalena Müller-Gerbl, and Victor Valderrabano. "Aging and Osteoarthritis: An Inevitable Encounter?" Journal of Aging Research 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/950192.

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Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are freque

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Leonova, Elena I., Angelina V. Chirinskaite, and Julia V. Sopova. "Atherosclerosis is a side effect of cellular senescence." Research Results in Pharmacology 8, no. (2) (2022): 1–9. https://doi.org/10.3897/rrpharmacology.8.81358.

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Atherosclerosis is a systemic autoimmune disease of the arterial wall characterized by chronic inflammation, high blood pressure, oxidative stress, and progressive loss of cell and organ function with aging. An imbalance of macrophage polarization is associated with many aging diseases, including atherosclerosis. The polarization toward the pro-inflammatory M1 macrophage is a major promoter of the atheroma formation. It is known that efferocytosis, or ingestion of apoptotic cells, is stimulated by M2 macrophage polarization. A failure of efferocytosis leads to the prolongation of chronic patho

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Gentile, Pietro, and Simone Garcovich. "Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects." International Journal of Molecular Sciences 22, no. 4 (2021): 1538. http://dx.doi.org/10.3390/ijms22041538.

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The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this syst

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