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Dissertations / Theses on the topic 'Cell gap junction'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

John, Scott Addis. "The gap junction : a site of cell to cell communication." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280273.

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2

Cottrell, Graham Trevor. "Functional characteristics of heterogeneous Cx40/Cx43 gap junction channel formation." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279862.

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Cells of the cardiovascular system express multiple connexins (Cx) with Cx40 and Cx43 being commonly coexpressed in many tissues. The expression levels of connexins are dynamic and can vary in response to a growth stimulus. It is not clear why cells express multiple connexins, or what advantage such dynamic regulation of expression patterns have on cell function. These issues are further complicated by the ability of some connexins to interact to form heterogeneous gap junction channels, with little being known regarding functional properties of such channels. The purpose of these experiments

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3

Li, Wing-man Michelle, and 李穎雯. "Gap junction regulates the blood-testis barrier dynamics during spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45450225.

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4

Feldman, Paul Andrew. "Connexin biosynthesis and ilimaquinone modulation of gap junction formation and removal." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23886.

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Gap junctions are membrane channels between closely apposed cells that allow for intercellular exchange of small molecules. These channels are formed from a family homologous proteins known as connexins (Cx). In the present study we studied connexin trafficking within the cell with particular emphasis on 1/ the mechanisms of gap junction formation and removal and on 2/ the early events associated with connexin biosynthesis. The mechanisms of gap junction formation and removal were studied by treating Normal Rat Kidney and BICR-MlR$ sb{ rm k}$ rat mammary tumour cells with ilimaquinone (IQ), a

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5

Banerjee, Debarshi. "Investigation of novel functions of a gap junction protein, connexin46." Diss., Kansas State University, 2010. http://hdl.handle.net/2097/6694.

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Doctor of Philosophy<br>Department of Biochemistry<br>Dolores J. Takemoto<br>Connexin proteins are the principle structural components of gap junction channels that connect the cytoplasm of two cells and maintain direct intercellular communication through the exchange of ions, small molecules and cellular metabolites. Colocalization and tissue-specific expression of diverse connexin molecules are reported to occur in a variety of organs. Impairment of gap junctional intercellular communication, caused by mutations, gain of function or loss of function of connexins, is involved in a number of d

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6

Shaw, Jeremy Joseph Porter. "The Implications Of Gap Junction Inhibition In Jurkat Cell-CellCommunication And Proliferation." Kent State University Honors College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1398988837.

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7

Elihu, David Morad. "Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37974.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.<br>Includes bibliographical references (leaves 80-84).<br>While many have explored how vascular processes alter gap junction communication and composition few have analyzed the role of specific gap junction connexin proteins in regulating cellular communication and wound healing. Using RNA interference or peptide inhibitors to downregulate specific connexins we examined the role of gap junctions in intercellular diffusion, calcium excitation, and in mediating the expression of vascular regulators tr

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8

Solan, Joell L. "Examination of the regulation of gap junction communication and connexin 43 phosphorylation during the cell cycle /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/9292.

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9

Johnson, Tiffany Lynn. "Endothelial Cell Function Using a Tissue Engineered Blood Vessel Model: A Case Study of Cell-Cell Communication." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-04032006-120602/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2006.<br>Pollman, Matthew, Committee Member ; Galis, Zorina, Committee Member ; McIntire, Larry, Committee Member ; Taylor, W Robert, Committee Member ; Jo, Hanjoong, Committee Member ; Nerem, Robert, Committee Chair.

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10

Shirdel, Mona. "Differences in Cell Junctions of Colorectal Cancer with a Pushing or Infiltrative Growth Pattern : The Role of Gap Junction Protein beta 3." Thesis, Umeå universitet, Patologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85608.

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Colorectal cancer (CRC) has either an infiltrative or pushing growth pattern, and patients in the former group have a worse prognosis. Infiltrative tumours are linked to epithelial-mesenchymal transition, which in turn is associated with increased cellular migration. As there is no molecular model that entirely describes the difference between infiltrative and pushing configurations we investigated if differences found in cell junctions between tumour cells (in the core of the tumour) could explain the different growth patterns. A PCR array targeting cell junction genes was performed on one in

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11

Li, Yee-kwan, and 李怡君. "Investigation of the gap junction intercellular communication between embryonic stem cells and connexin-43 over-expressing human foreskinfibroblasts and HeLa cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46700730.

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12

Holzbecher, André Jörg. "Function of interneuronal gap junctions in hippocampal sharp wave-ripples." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19364.

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Eine einzigartige experimentelle Beobachtung, welche die Basis für eine ganzheitliche, neurowissentschafliche Theorie für Gedächtnis darstellen könnte, sind sharp wave-ripples (SWRs). SWRs werden in lokalen Neuronennetzwerken erzeugt und sind wichtig für Gedächtniskonsolidierung; SWRs sind charakteristische Ereignisse der lokalen Feldpotentiale im Hippocampus des Säugetiers, die in Phasen von Schlaf und Ruhe vorkommen. Eine SWR besteht aus einer sharp wave, einer ≈ 100 ms langen Auslenkung des Feldpotentials, welche mit ripples, 110–250 Hz Oszillationen, überlagert ist. Jüngste Experimente be

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13

Jacobsen, Nicole L., Tasha K. Pontifex, Hanjun Li, et al. "Regulation of Cx37 channel and growth-suppressive properties by phosphorylation." COMPANY OF BIOLOGISTS LTD, 2017. http://hdl.handle.net/10150/625983.

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Growth suppression mediated by connexin 37 (Cx37; also known as GJA4) requires interaction between its C-terminus and functional pore-forming domain. Using rat insulinoma cells, we show that Cx37 induces cell death and cell cycle arrest, and slowed cell cycling. Whether differential phosphorylation might regulate intramolecular interactions, and consequently the growth-suppressive phenotype, is unknown. Protein kinase C inhibition increased the open state probability of low-conductance gap junction channels (GJChs) and reduced GJCh closed state probability. Substituting alanine at serine resid

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14

Akins, Mark S. "The Role of the Neuronal gap Junction Protein Connexin36 in Kainic Acid Induced Hippocampal Excitotoxicity." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30392.

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Kainic acid induced excitotoxicity causes pyramidal cell death in the CA3a/b region of the hippocampus. Electrical synapses, gap junctional communication, and single membrane channels in non-junctional membranes (hemichannels) composed of connexin36 (Cx36) have been implicated in both seizure propagation and the spread of excitotoxic cell death. In rats, Cx36 protein is expressed by pyramidal neurons. Localization of protein in mouse, however, is highly controversial. Expression is reported to be restricted to hippocampal interneurons yet the same excitotoxic mechanisms (electrical and metabol

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15

Fumagalli, Amos. "Deciphering CXCR4 and ACKR3 interactomes reveals an influence of ACKR3 upon Gap junctional intercellular communication." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT036.

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Le récepteur atypique ACKR3 et le récepteur CXCR4 sont des récepteurs couplés aux protéines G appartenant à la famille des récepteurs CXC des chimiokines. Ces deux récepteurs sont activés par la chimiokine CXCL12 et sont surexprimés dans de nombreux cancers comme les gliomes, dont ils favorisent la prolifération et le caractère invasif. Le récepteur CXCR4 active des voies de signalisation qui dépendent de la protéine Gi et des β-arrestines et s’associe à plusieurs protéines impliquées dans la transduction du signal, le trafic et la localisation cellulaire du récepteur. Par contre, les mécanism

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16

Žukauskas, Algirdas, and Nerijus Lukšys. "Tarpląstelinio sąveikavimo imitacinio modelio optimizavimas ir tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100826_143410-25441.

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Darbe yra nagrinėjama tarpląstelinių plyšinių jungčių modeliavimo sistema (GJM – Gap Juncion Model, sukurta N. Paulausko - Kauno technologijos universiteto, informatikos fakulteto magistrantas). Pagrindinis tyrimo objektas yra optimizavimo uždavinys. Viename iš sistemos modulių, pasinaudojant globalaus optimizavimo metodais, yra ieškoma modelio parametrų, su kuriais modelio ir realių eksperimentų (gautų iš sistemos užsakovų Niujorko, Yeshiva universiteto, Alberto Einšteino medicinos koledžo laboratorijos (prof. Felikso Bukausko)) rezultatai skirtųsi minimaliai arba sutaptų. Šiuo atveju yra mod

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17

Long, Amy Carise. "Influence of environmental and chemical factors on cellular signaling in lens epithelial cells." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186677862.

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18

Neyton, Jacques. "Propriétés des canaux des jonctions Gap et leur modulation par les neurotransmetteurs : analyse électrophysiologique." Paris 6, 1986. http://www.theses.fr/1986PA066298.

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19

Ko, Yu-Shien. "Connexin heterogeneity in vascular cell gap junctions." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393781.

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20

Chepied, Amandine. "Étude de l'implication de la Connexine 43 dans le processus d'invasion des glioblastomes humains." Thesis, Poitiers, 2015. http://www.theses.fr/2015POIT2274/document.

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Depuis plusieurs décennies, la communication intercellulaire par jonctions gap (CIJG) est connue pour être impliquée dans la cancérogenèse. Cette implication semble complexe par le fait que les connexines pourraient augmenter la capacité d’invasion des cellules cancéreuses tout en diminuant leur prolifération. Ceci était particulièrement observé pour la connexine 43 (Cx43) dans le cas de cellules de gliomes. Or, les propriétés d’invasion des gliomes de haut grade, les glioblastomes multiformes (GBM), les rendent difficiles à supprimer par résection chirurgicale et favorisent leur récidive. Afi

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21

O'Connor, Simon. "Modelling gap junction-coupled networks of olfactory bulb mitral cells." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55041/.

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The olfactory bulb forms the first level of input integration for olfactory receptor neurons that receive stimuli from odorant molecules in the nose. The olfactory bulb is multi channel in nature, with each channel containing its own populations of mitral cells. These channels each handle the input from neurons expressing a single type of olfactory receptor protein tuned to a unique range of odorant structures. I have constructed a mitral cell gap-junction network model with morphologically accurate mitral cells to study the behaviour of mitral cells in a channel population. The passive parame

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22

Sia, Michael Augustine. "Gap junctional intercellular communication in quiescent and heterocellular mammary populations." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29786.pdf.

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23

Tomai, Evangelia. "Gap junctional communication in lung cancer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ54488.pdf.

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24

Peng, Qian, and 彭茜. "Expression and regulation of connexin 43 in human embryonic stemcells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45591362.

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25

Mok, Wing-yee Bobo. "Expression of Gap-junctional connexin 31 in rat testis /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21254084.

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26

莫穎兒 and Wing-yee Bobo Mok. "Expression of Gap-junctional connexin 31 in rat testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223205.

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27

Yeh, Hung-I. "Vascular cell gap junctions : diversity of connexin expression in healthy and injured artery." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265945.

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28

Myers, Janette Bernadette. "Application of Single Particle Electron Microscopy to Native Lens Gap Junctions and Intrinsically Disordered Signaling Complexes." PDXScholar, 2019. https://pdxscholar.library.pdx.edu/open_access_etds/5008.

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Gap junctions are a class of membrane proteins that facilitate cell-to-cell communication by forming channels that directly couple the cytoplasm of neighboring cells. The channels are composed of monomers called connexins. Humans express 21 connexin isoforms in a cell-type specific fashion, and each isoform has distinct mechanisms of permeation and regulation. Co-assembly of multiple isoforms into a single intercellular channel can change channel properties, such as conductance and selectivity to substrates (e.g., ions, metabolites and signaling molecules). However, the mechanistic basis for t

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29

Bader, Almke [Verfasser]. "Integration of gap junction coupling in adenosine signalling of endothelial cells / Almke Bader." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2018. http://d-nb.info/1165251574/34.

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30

Mather, Simon. "Endothelial cell modulation of vascular tone by EDHF and gap junctional communication." Thesis, University of Bath, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418594.

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31

Alcami, Ayerbe José. "Interactions synaptiques entre les interneurones de la couche moléculaire du cervelet." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T021.

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Les interneurones de la couche moléculaire du cervelet (ICM: cellules en panier et cellules étoilées) sont connectés par des synapses électriques fréquentes et puissantes chez les jeunes rats et souris autour de la fin de la deuxième semaine postnatale. Les courants capacitifs des ICM montrent une composante lente qui reflète la charge des interneurones couplés électriquement. Leur analyse permet de quantifier le nombre de cellules directement couplées à une cellule et le nombre équivalent de cellules couplées (Alcami et Marty, soumis), et d'établir une difference de couplage entre les cellule

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32

Das, Satyabrata. "Role of protein kinase C-gamma in the regulation of lens gap junctions." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2330.

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33

He, Dingsheng. "Connexins 40 and 43 form heteromeric gap junction channels in vascular smooth muscle cells." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284991.

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Gap junction channels connect the cytoplasms of adjacent cells and provide a pathway for the exchange of materials between cells. The nature of the materials exchanged is determined by the biophysical characteristics of the channels. The functional gap junction channel is composed of paired hemichannels (connexons) from each cell. Connexons are hexamers of protein subunits called connexins (Cx). Of the 15 connexin genes found in the mammalian genome, the products of only two, Cx40 and Cx43 have been localized in vascular smooth muscle cells (SMC) (1;2). We have been interested in identifying t

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34

Bigelow, Kristina Marie. "Effects of quinolines on SW480 colorectal cancer cells: gap junction dependent and independent pathways." Thesis, Kansas State University, 2014. http://hdl.handle.net/2097/17920.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Thu Annelise Nguyen<br>Colorectal cancer is one of the most common cancers in the United States with an early detection rate of only 39%. Colorectal cancer cells along with other cancer cells exhibit many deficiencies in cell-to-cell communication, particularly gap junctional intercellular communication (GJIC). GJIC has been reported to diminish as cancer cells progress. Gap junctions are intercellular channels composed of connexin proteins, which mediate the direct passage of small molecules from one cell to the next. The

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35

Locke, Darren Richard. "Developmental expression and structure-function of connexins in the mouse mammary gland." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324630.

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36

McEvoy, Lorraine Anne Frances. "Endothelial cell modulation of smooth muscle contraction by gap junctional communication and vascular autacoids." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398586.

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37

Pirman, Megan. "An In Vitro Study on the Role of Endothelial Cell Connexin43 Gap Junctions in the Regulation of Hematopoietic Stem and Progenitor Cells Traffic." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1267459743.

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38

Madgwick, Daniel. "Functional role of connexin 46 in lens epithelial cell differentiation and growth." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/704.

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39

Oberoi, Pankaj. "In vivo physiology of gap junctions between supporting cells in the organ of Corti." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85264.

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Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.<br>Includes bibliographical references (p. 188-195).<br>by Pankaj Oberoi.<br>Ph.D.

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40

Imbeault, Sophie, Lianne Gauvin, Hadi Toeg, et al. "The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cells." BioMed Central, 2009. http://hdl.handle.net/10150/610072.

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BACKGROUND:Gap junction protein and extracellular matrix signalling systems act in concert to influence developmental specification of neural stem and progenitor cells. It is not known how these two signalling systems interact. Here, we examined the role of ECM components in regulating connexin expression and function in postnatal hippocampal progenitor cells.RESULTS:We found that Cx26, Cx29, Cx30, Cx37, Cx40, Cx43, Cx45, and Cx47 mRNA and protein but only Cx32 and Cx36 mRNA are detected in distinct neural progenitor cell populations cultured in the absence of exogenous ECM. Multipotential Typ

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41

Morin, Mario Y. "Enhancement of neural cell regeneration and survival by altering gap junctional communication following brain injury." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27397.

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The adult brain is particularly susceptible to injury given that it lacks significant regenerative capacity. The presence of rare neural stem and progenitor cells - cells capable of self-renewal and specification to a neuronal or a glial lineage - in specific areas of the adult central nervous system (CNS) offers new hope for therapeutic cell replacement. Our laboratory has previously implicated connexin32 (Cx32) in participating in neural progenitor cell fate determination to an oligodendrocyte lineage (Melanson-Drapeau et al., 2003; Hebb et al., submitted). Based on these previous findings,

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42

Bonness, Viola. "The appearance of amino acid transmitters, their receptors and gap junctions in the developing chick retina." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313801.

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43

Charolidi, Nicoletta. "Gap junctions in arterial smooth muscle cells : relationship between Connexin43 expression, intercellular communication and phenotype." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501473.

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44

Almosni, Samy. "Growth, structural and electro-optical properties of GaP/Si and GaAsPN/ GaP single junctions for lattice-matched tandem solar cells on silicon." Thesis, Rennes, INSA, 2015. http://www.theses.fr/2015ISAR0010/document.

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Cette thèse se concentre sur la fabrication de cellule solaire IIIN- V sur substrat de GaP (001) et sur la croissance de couche de GaP sur Si (001). Le but est de réaliser des cellules solaires hautes efficacité sur un substrat à faible coût afin de les intégrer dans des centrales solaire photovoltaïque sous concentration. Les principaux résultats obtenus montrent : - L’importance de l’utilisation d’AlGaP en tant que couche de prénucléation pour annihiler les parois d’antiphase à l’interface GaP/ Si (néfaste pour les propriétés optoélectroniques des dispositifs) - De nombreuses similitude entr

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45

Mei, Xiangyang. "Preparation of pyramidal textured GaP p-n junctions and their applications to alpha radio-voltaic cells, ARVCs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ33972.pdf.

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46

Richter, Nadine [Verfasser]. "Properties of gap junctional coupling among glial cells in the central nervous system / Nadine Richter." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1074871057/34.

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47

Speier, Stephan. "Electrophysiological characterization of insulin secreting [beta]-cells [beta-cells] in pancreatic tissue slices." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=975113127.

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48

Mathumba, Penny. "Aluminium and gold functionalized graphene quantum dots as electron acceptors for inverted Schottky junction type rainbow solar cells." University of Western Cape, 2020. http://hdl.handle.net/11394/7232.

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Philosophiae Doctor - PhD<br>The main aim of this study was to prepare band gap-engineered graphene quantum dot (GQD) structures which match the different energies of the visible region in the solar spectrum. These band gap-engineered graphene quantum dot structures were used as donor materials in rainbow Schottky junction solar cells, targeting all the energies in the visible region of the solar spectrum for improved solar-to-electricity power conversion efficiency. Structural characterisation of the prepared nanomaterials under solid-state nuclear magnetic resonance spectroscopy (SS-NMR) sho

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49

Ceballos, Cesar Augusto Celis. "Modelo computacional da camada ganglionar da retina para estudo de mecanismos responsáveis por sua faixa dinâmica." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-23102013-150346/.

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Teoricamente, conexões por sinapses elétricas entre neurônios poderiam levar ao aumento da faixa de resposta dinâmica da rede neural. A faixa de resposta dinâmica de uma rede de neurônios pode ser definida como a faixa de valores de intensidade dos estímulos de entrada para a qual o conjunto de neurônios produz resposta antes de atingir a saturação. Em um cenário biológico, propôs-se que junções gap entre células ganglionares da retina aumentariam a faixa dinâmica da retina. O teste experimental dessa proposta apresenta várias dificuldades, o que torna a modelagem computacional uma alternativa

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50

Kylmäoja, E. (Elina). "Osteoclastogenesis from bone marrow and peripheral blood monocytes:the role of gap junctional communication and mesenchymal stromal cells in the differentiation." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526221045.

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Abstract Osteoclasts are multinuclear bone degrading cells differentiated from monocytes which can be isolated from bone marrow and peripheral blood. Complex signaling between osteoclast precursors and other bone cells, such as mesenchymal stromal cells (MSC) occurs during the differentiation. Gap junctional communication (GJC) is one of the mechanisms in the cell fusion. GJC can be modulated with several substances such as the specific GJC stimulators, antiarrhythmic peptides (AAP). Due to their promising clinical value in the treatment of cardiac disorders, the effects of AAPs in cardiac tis

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