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Journal articles on the topic 'Cell Line, Tumor'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lichtenauer, Urs D., Igor Shapiro, Klaus Geiger, et al. "Side Population Does Not Define Stem Cell-Like Cancer Cells in the Adrenocortical Carcinoma Cell Line NCI h295R." Endocrinology 149, no. 3 (2007): 1314–22. http://dx.doi.org/10.1210/en.2007-1001.

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Recent evidence suggests the existence of a stem cell-like subpopulation of cells in hematological and solid tumor entities, which determine the malignant phenotype of a given tumor through their proliferative potential and chemotherapy resistance. A recently used technique for the isolation of this cell population is through exclusion of the vital dye Hoechst 33342, which defines the so-called side population (SP). Herein we demonstrate the presence of SP cells in a variety of adrenal specimens, including primary cultures of human adrenocortical tumors and normal adrenal glands as well as est

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2

Crawford, Sarah Adelaide. "Microvesicles Secreted by Glioblastoma Multiforme DBTRG-05MG Tumor Cell Line Contain Proteins Involved in Tumor Invasion, Stemness and Immunosuppression." Cancer Research and Cellular Therapeutics 4, no. 1 (2020): 01–09. http://dx.doi.org/10.31579/2640-1053/067.

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3

Lapointe, Henry, Howard Lampe, and Diponkar Banerjee. "Head and Neck Squamous Cell Carcinoma Cell Line-Induced Suppression of in vitro Lymphocyte Proliferative Responses." Otolaryngology–Head and Neck Surgery 106, no. 2 (1992): 149–58. http://dx.doi.org/10.1177/019459989210600205.

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Tumour-infiltrating lymphocytes (TILS) are often difficult to expand in vitro. In some cases this has been attributable to immunosuppression mediated by the elaboration of prostaglandins by either tumor cells or tumor-infiltrating monocytes. In this laboratory, freshly prepared TILs containing single-cell suspensions of head and neck tumors displayed both poor proliferation as well as minimal responsiveness to indomethacin-mediated reversal of immunosuppression. In order to investigate tumor-mediated immunosuppression further, a system was developed whereby a new cell line of head and neck squ

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4

Magatti, M., S. De Munari, E. Vertua, S. Acali, and O. Parolini. "Amniotic mesenchymal tissue cells inhibit tumor cell line proliferation." Placenta 32 (October 2011): S336. http://dx.doi.org/10.1016/j.placenta.2011.07.063.

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5

Bagriacik, Emin Umit, Mustafa Kemali Baykaner, Melek Yaman, et al. "Establishment of a Primary Pleomorphic Xanthoastrocytoma Cell Line." Neurosurgery 70, no. 1 (2011): 188–97. http://dx.doi.org/10.1227/neu.0b013e3182262c5b.

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Abstract BACKGROUND Anaplastic pleomorphic xanthoastrocytoma is an aggressively growing, malignant, and eventually fatal tumor of the central nervous system. Testing chemotherapeutic drug sensitivity under in vitro conditions would be a useful strategy to determine sensitive or resistant drugs for fatal brain cancers. OBJECTIVE To establish primary cell cultures of excised tumor tissue from pleomorphic xanthoastrocytoma–bearing patients and to test their sensitivity against various anticancer chemotherapy drugs. METHODS Prepared suspensions of the excised tumor tissue from a patient who had a

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Bremmer, Felix, Hanibal Bohnenberger, Stefan Küffer, et al. "Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines." Disease Markers 2019 (September 3, 2019): 1–14. http://dx.doi.org/10.1155/2019/8298524.

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Malignant germ cell tumors (GCT) are the most common malignant tumors in young men between 18 and 40 years. The correct identification of histological subtypes, in difficult cases supported by immunohistochemistry, is essential for therapeutic management. Furthermore, biomarkers may help to understand pathophysiological processes in these tumor types. Two GCT cell lines, TCam-2 with seminoma-like characteristics, and NTERA-2, an embryonal carcinoma-like cell line, were compared by a quantitative proteomic approach using high-resolution mass spectrometry (MS) in combination with stable isotope

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7

Chang, Inyoub, Takbum Ohn, Daeun Moon, Young Hee Maeng, Bo Gun Jang, and Sang-Pil Yoon. "SNU-333 Cells as an Appropriate Cell Line for the Orthotopic Renal Cell Carcinoma Model." Technology in Cancer Research & Treatment 20 (January 2021): 153303382110384. http://dx.doi.org/10.1177/15330338211038487.

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Objective: To investigate a feasible candidate for an appropriate cell line for the orthotopic renal cell carcinoma (RCC) model. Methods: Normal human proximal tubule cells (HK-2) and RCC cells were used for MTT assay, Western blotting, sphere-forming assay, and orthotopic injection of BALB/c-nude mice. Immunohistochemistry was adopted in tissue arrays and orthotopic tumors. Results: Primary RCC cells showed resistance to a GPX4 inhibitor compared to HK-2 and to metastatic RCC cells, Caki-1. Caki-2 and SNU-333 cells showed resistance to ferroptosis via increased GPX4 and FTH1, respectively. RC

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8

Ross, Douglas T., and Charles M. Perou. "A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines." Disease Markers 17, no. 2 (2001): 99–109. http://dx.doi.org/10.1155/2001/850531.

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Cell lines derived from human tumors have historically served as the primary experimental model system for exploration of tumor cell biology and pharmacology. Cell line studies, however, must be interpreted in the context of artifacts introduced by selection and establishment of cell linesin vitro. This complication has led to difficulty in the extrapolation of biology observed in cell lines to tumor biologyin vivo. Modern genomic analysis tool like DNA microarrays and gene expression profiling now provide a platform for the systematic characterization and classification of both cell lines and

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9

Shamova, T. V., A. O. Sitkovskaya, E. E. Rostorguev, N. S. Kuznetsova, and S. E. Kavitsky. "Preparation of primary glial tumor cell lines." Perm Medical Journal 37, no. 5 (2021): 79–89. http://dx.doi.org/10.17816/pmj37579-89.

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Objective. The aim of this work was to obtain the primary cell lines of brain malignant tumors using the explant method. Materials and methods. Thirteen patients of both sexes, aged 22 to 66, were recruited. The tumor material of the patients was fragmented and placed in flasks with complete nutrient medium for glial tumor cells. Subsequently, the material was photographed at various stages of cultivation, the cell morphology was determined, and the rate of monolayer formation at the zero and first passages was assessed. Results. As a result, thirteen primary human cell lines of gl

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10

Shamova, T. V., A. O. Sitkovskaya, E. E. Rostorguev, N. S. Kuznetsova, and S. E. Kavitsky. "Preparation of primary glial tumor cell lines." Perm Medical Journal 37, no. 5 (2021): 79–89. http://dx.doi.org/10.17816/pmj37579-89.

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Objective. The aim of this work was to obtain the primary cell lines of brain malignant tumors using the explant method. Materials and methods. Thirteen patients of both sexes, aged 22 to 66, were recruited. The tumor material of the patients was fragmented and placed in flasks with complete nutrient medium for glial tumor cells. Subsequently, the material was photographed at various stages of cultivation, the cell morphology was determined, and the rate of monolayer formation at the zero and first passages was assessed. Results. As a result, thirteen primary human cell lines of gl

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11

Funakoshi, Akihiro, Kayoko Tateishi, Michiyo Tsuru, et al. "Pancreastatin producing cell line from human pancreatic islet cell tumor." Biochemical and Biophysical Research Communications 168, no. 2 (1990): 741–46. http://dx.doi.org/10.1016/0006-291x(90)92384-c.

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12

Park, G. J., and C. H. Lee. "P1.18. Brefeldin A induced apoptosis on salivary gland tumor cell line (SGT cell line)." Oral Oncology Supplement 3, no. 1 (2009): 128. http://dx.doi.org/10.1016/j.oos.2009.06.304.

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13

Boy-Lefèvre, M. L., J. R. Nefussi, D. Paulin, et al. "Collagen expression during teratocarcinoma cell line-induced endochondral bone tumor." Journal of Histochemistry & Cytochemistry 34, no. 7 (1986): 835–39. http://dx.doi.org/10.1177/34.7.3519748.

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Collagen immunotyping by indirect immunofluorescence was performed in order to investigate the sequential development of bone formation. Osseous tumors were obtained after subcutaneous injection of 3/A/1D-1 teratocarcinoma cell line into 129/Sv mice (Nicolas et al., 1980). Frozen sections of developing tumors were incubated with specific antibodies directed against Types I, II, III, IV, and IX collagens. On Day 9, the expression of Type I and Type III collagens was correlated with the proliferation of mesenchymal cells. From Day 10, chondrogenesis was characterized by the occurrence of cartila

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14

Turner, AM, KM Zsebo, F. Martin, FW Jacobsen, LG Bennett, and VC Broudy. "Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors." Blood 80, no. 2 (1992): 374–81. http://dx.doi.org/10.1182/blood.v80.2.374.374.

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Abstract Human stem cell factor (SCF) acts in the presence of other growth factors to stimulate the growth of primitive hematopoietic progenitor cells. These effects are performed by activation of the SCF receptor, c- kit. Because of the potential use of SCF in patients undergoing chemotherapy and bone marrow transplantation, the effect of SCF on nonhematopoietic tumors requires investigation. To determine whether human tumor cell lines display c-kit receptors, we performed binding experiments with 125I-SCF on a breast carcinoma cell line (Du4475), a gastric carcinoma cell line (KATO III), a m

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Turner, AM, KM Zsebo, F. Martin, FW Jacobsen, LG Bennett, and VC Broudy. "Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors." Blood 80, no. 2 (1992): 374–81. http://dx.doi.org/10.1182/blood.v80.2.374.bloodjournal802374.

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Human stem cell factor (SCF) acts in the presence of other growth factors to stimulate the growth of primitive hematopoietic progenitor cells. These effects are performed by activation of the SCF receptor, c- kit. Because of the potential use of SCF in patients undergoing chemotherapy and bone marrow transplantation, the effect of SCF on nonhematopoietic tumors requires investigation. To determine whether human tumor cell lines display c-kit receptors, we performed binding experiments with 125I-SCF on a breast carcinoma cell line (Du4475), a gastric carcinoma cell line (KATO III), a melanoma c

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16

Sonkin, Dmitriy, Mehedi Hassan, Denis J. Murphy, and Tatiana V. Tatarinova. "Tumor Suppressors Status in Cancer Cell Line Encyclopedia." Molecular Oncology 7, no. 4 (2013): 791–98. http://dx.doi.org/10.1016/j.molonc.2013.04.001.

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17

Danila, D. C. "A Human Pituitary Tumor-Derived Folliculostellate Cell Line." Journal of Clinical Endocrinology & Metabolism 85, no. 3 (2000): 1180–87. http://dx.doi.org/10.1210/jc.85.3.1180.

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18

Hynes, N. E., R. Jaggi, S. C. Kozma, et al. "New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line." Molecular and Cellular Biology 5, no. 1 (1985): 268–72. http://dx.doi.org/10.1128/mcb.5.1.268.

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A line of mouse mammary epithelial cells (NMuMG) has been characterized for its ability to be stably transfected with exogenous DNA. A transfection frequency of at least 1 cell per 1,000 was obtained with the pSV2neo plasmid. Several thousand G418-resistant NMuMG cell clones can easily be generated in cotransfection of genomic DNA and pSV2neo. The NMuMG cells were isolated from normal mammary glands and do not form malignant lesions when injected into nude mice. We have cotransfected NMuMG cells with pSV2neo and genomic DNA from the human EJ bladder carcinoma line, a cell line which contains a

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Hynes, N. E., R. Jaggi, S. C. Kozma, et al. "New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line." Molecular and Cellular Biology 5, no. 1 (1985): 268–72. http://dx.doi.org/10.1128/mcb.5.1.268-272.1985.

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A line of mouse mammary epithelial cells (NMuMG) has been characterized for its ability to be stably transfected with exogenous DNA. A transfection frequency of at least 1 cell per 1,000 was obtained with the pSV2neo plasmid. Several thousand G418-resistant NMuMG cell clones can easily be generated in cotransfection of genomic DNA and pSV2neo. The NMuMG cells were isolated from normal mammary glands and do not form malignant lesions when injected into nude mice. We have cotransfected NMuMG cells with pSV2neo and genomic DNA from the human EJ bladder carcinoma line, a cell line which contains a

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20

Stuelten, Christina H., Susan D. Mertins, Johanna I. Busch, et al. "Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel." STEM CELLS 28, no. 4 (2010): 649–60. http://dx.doi.org/10.1002/stem.324.

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21

Zhou, B., D. Zhang, S. M. Pei, et al. "Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line." Polish Journal of Veterinary Sciences 20, no. 1 (2017): 103–10. http://dx.doi.org/10.1515/pjvs-2017-0014.

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Abstract Canine mammary tumors are the most common neoplasms in intact female dogs. The surgery cannot always solve the problem, chemotherapy are recommend to these patients. However, chemotherapy could always fail because of multidrug resistance (MDR). Through stepwise increasing 5-Fluorouracil (5-FU) concentration in the culture medium, a 5-FU-resistant canine mammary tumor cell line CMT7364/5-FU was established to disclose the molecular mechanism of the drug resistance. Cell morphology, cell sensitivity to drugs, growth curves, expression of proteins, and chemo-sensitivity in vivo were comp

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22

Gabbert, Helmut Erich, Claus-Dieter Gerharz, Rainer Engers, Wolfgang Müller-Klieser, and Roland Moll. "Terminally differentiated postmitotic tumor cells in a rat rhabdomyosarcoma cell line." Virchows Archiv B Cell Pathology 55, no. 1 (1988): 255–61. http://dx.doi.org/10.1007/bf02896584.

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23

Pendergast, Julie S., Mijung Yeom, Bryan A. Reyes, Yoshihiro Ohmiya, and Shin Yamazaki. "Disconnected circadian and cell cycles in a tumor-driven cell line." Communicative & Integrative Biology 3, no. 6 (2010): 536–39. http://dx.doi.org/10.4161/cib.3.6.12841.

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24

Perozziello, Gerardo, Rosanna La Rocca, Gheorghe Cojoc, et al. "Microfluidic Devices Modulate Tumor Cell Line Susceptibility to NK Cell Recognition." Small 8, no. 18 (2012): 2886–94. http://dx.doi.org/10.1002/smll.201200160.

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25

Okumura, Ataru, Takuji Tanaka, and Hideki Mori. "Juxtaglomerular cell tumor cell line producing active renin and its precursors." Virchows Archiv B Cell Pathology Including Molecular Pathology 64, no. 1 (1993): 303–7. http://dx.doi.org/10.1007/bf02915127.

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26

Katano, Mitsuo, Eiro Kubota, Fumio Nagumo, Tatsuya Matsuo, Takeharu Hisatsugu, and Jutaro Tadano. "Inhibition of tumor cell growth by a human B-cell line." Biotherapy 8, no. 1 (1994): 1–6. http://dx.doi.org/10.1007/bf01878115.

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27

Takahashi, H., M. Kawakami, H. Ishikawa, T. Nakahara, and A. Tanaka. "Establishment of lingual squamous cell carcinoma cell line, cancer stem cell line and the grafted tumor cell line derived from same cancer tissue." Journal of Oral and Maxillofacial Surgery 72, no. 9 (2014): e168. http://dx.doi.org/10.1016/j.joms.2014.06.302.

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28

Pozzi, Valentina, Davide Sartini, Romina Rocchetti, et al. "Identification and Characterization of Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma Cell Lines." Cellular Physiology and Biochemistry 36, no. 2 (2015): 784–98. http://dx.doi.org/10.1159/000430138.

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Background/Aims: Head and neck squamous cell carcinoma (HNSCC) ranks sixth worldwide for tumor-related mortality. A subpopulation of tumor cells, termed cancer stem cells (CSCs), has the ability to support cancer growth. Therefore, profiling CSC-enriched populations could be a reliable tool to study cancer biology. Methods: We performed phenotypic characterization of 7 HNSCC cell lines and evaluated the presence of CSCs. CSCs from Hep-2 cell line and HNSCC primary cultures were enriched through sphere formation and sphere-forming cells have been characterized both in vitro and in vivo. In addi

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Shklovskaya, Elena, Jenny H. Lee, Su Yin Lim, et al. "Tumor MHC Expression Guides First-Line Immunotherapy Selection in Melanoma." Cancers 12, no. 11 (2020): 3374. http://dx.doi.org/10.3390/cancers12113374.

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Immunotherapy targeting T-cell inhibitory receptors, namely programmed cell death-1 (PD-1) and/or cytotoxic T-lymphocyte associated protein-4 (CTLA-4), leads to durable responses in a proportion of patients with advanced metastatic melanoma. Combination immunotherapy results in higher rates of response compared to anti-PD-1 monotherapy, at the expense of higher toxicity. Currently, there are no robust molecular biomarkers for the selection of first-line immunotherapy. We used flow cytometry to profile pretreatment tumor biopsies from 36 melanoma patients treated with anti-PD-1 or combination (

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30

Lu, Jie, Jie Jin, Weilai Xu, Zhimei Chen, and Wei Ding. "The Establishment of Mice Model with Myelodysplastic Syndrome Cell Line MUTZ-1 Cell." Blood 106, no. 11 (2005): 4911. http://dx.doi.org/10.1182/blood.v106.11.4911.4911.

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Abstract Objective To establish myelodysplastic syndrome cell line MUTZ-1 cell mice model. Methods 75 SCID mice and 10 BALB/CA-node mice were studied in this experiment. MDS-REBT cell line MUTZ-1 cells were cultured in vitro and 1 x108 /ml cell were subcutancously implanted in 4~6-week-old First-Generation SCID mice and BALB/CA-node mice respectively. The subcutancous tumor cells from First-Generation MDS-REBT cell line MUTZ1 cells mice model were respectively implanted in Second-Generation SCID mice and BALB/CA-node mice. The latent period and the rate of subcutancous tumor formation was obse

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Hsu, Wesley, Ahmed Mohyeldin, Sagar R. Shah, et al. "Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target." Journal of Neurosurgery 115, no. 4 (2011): 760–69. http://dx.doi.org/10.3171/2011.5.jns11185.

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Object Chordoma is a malignant bone neoplasm hypothesized to arise from notochordal remnants along the length of the neuraxis. Recent genomic investigation of chordomas has identified T (Brachyury) gene duplication as a major susceptibility mutation in familial chordomas. Brachyury plays a vital role during embryonic development of the notochord and has recently been shown to regulate epithelial-to-mesenchymal transition in epithelial-derived cancers. However, current understanding of the role of this transcription factor in chordoma is limited due to the lack of availability of a fully charac

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32

Fagerstedt, Klaus W., Tom Böhling, Harri Sihto, et al. "GNEN-1: a spontaneously immortalized cell line from gastric neuroendocrine neoplasia." Endocrine Connections 10, no. 9 (2021): 1055–64. http://dx.doi.org/10.1530/ec-21-0206.

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Mixed neuroendocrine-non-neuroendocrine neoplasms (MINEN) are rare tumors that consist of at least 30% of both neuroendocrine and non-neuroendocrine components. The data concerning the pathogenesis of MINEN suggest a monoclonal origin. We describe a spontaneously immortalized cell line derived from gastric MINEN called GNEN-1. Primary tumor consisted of components of high-grade neuroendocrine carcinoma and adenocarcinoma. The GNEN-1 cell line was initiated from metastatic tumor cells of peritoneal fluid and expresses a purely neuroendocrine phenotype. The GNEN-1 cell line grows as monolayers a

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33

Alexandros, Liappas, Mourouzis Iordanis, Zisakis Athanasios, Economou Konstantinos, Lea Robert-William, and Pantos Constantinos. "Cell-Type-Dependent Thyroid Hormone Effects on Glioma Tumor Cell Lines." Journal of Thyroid Research 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/856050.

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Purpose. The present study investigated the potential effects of long-term T3 treatment on glioma tumor cell lines. Thyroid hormone action on cell growth, differentiation and survival during development may be of therapeutic relevanceMethods and Results1321N1 cell line, an astrocytoma grade II, and U87MG, a glioblastoma grade IV, were exposed for 2 and 4 days in medium deprived of T3 and in medium containing 1 nM T3. T3 promoted re-differentiation in both cell lines. However, T3 increased cell proliferation in 1321N1 (2 days) which declined thereafter (4 days) while in U87MG resulted in suppre

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Okamura, Naoka, Katsuya Ikuta, Hiroki Tanaka, et al. "Anti-Proliferative Effect of Itraconazole On ALCL-Derived Cell Line." Blood 120, no. 21 (2012): 1367. http://dx.doi.org/10.1182/blood.v120.21.1367.1367.

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Abstract Abstract 1367 Background: Itraconazole (ITCZ) has been widely used for the treatment of fungal infection in the treatment of hematological malignancies. Recently, an anti-proliferative effect of ITCZ has been reported in solid tumors (Kim J et al. Cancer Cell 2010;17:388–399, Blake T et al. Cancer Res 2011;71:6764–6772). However, there has been no report on the effect of ITCZ on hematological malignancies. Therefore, we aimed to investigate the anti-proliferative effect of ITCZ on hematological malignancies in the present study. Methods: Daudi (Human Burkitt's lymphoma cell line), Jur

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Chung, Won Ho, and Chong Heon Lee. "Docetaxel Induces Apoptosis in Salivary Gland Tumor Cell Line." Korean Journal of Oral and Maxillofacial Pathology 41, no. 3 (2017): 113–20. http://dx.doi.org/10.17779/kaomp.2017.41.3.002.

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Ueda, Yasuo, Kenji Tanaka, Satoshi Morimoto, Koji Munechika, Yosio Kagitani, and Kazumasa Yokoyama. "Selective distribution of fibronectin to a tumor-cell line." Cancer Letters 31, no. 3 (1986): 261–65. http://dx.doi.org/10.1016/0304-3835(86)90146-1.

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Eggers, Hendrik, Philipp Ivanyi, Mareike Hornig, and Viktor Grünwald. "Predictive Factors for Second-Line Therapy in Metastatic Renal Cell Carcinoma: A Retrospective Analysis." Journal of Kidney Cancer and VHL 4, no. 1 (2017): 8–15. http://dx.doi.org/10.15586/jkcvhl.2017.59.

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Currently, about 50% of patients with metastatic renal cell carcinoma (mRCC) receive a second-line therapy. Therefore, the choice at each subsequent treatment line remains an important issue. In this retrospective study, we sought to identify pretreatment clinical parameters that could predict the likelihood of a patient receiving a second-line therapy. One hundred and sixty-one mRCC patients who received targeted therapy were evaluated. Descriptive statistics, Kaplan–Meier overall survival (OS), Cox regression, and binary logistic regression models were used for data analysis. Second-line the

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Xiao, Zhihui, Wenjun Wu, and Vladimir Poltoratsky. "Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line." Mediators of Inflammation 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/6589423.

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Chronic inflammation is associated with cancer. CXCL8 promotes tumor microenvironment construction through recruiting leukocytes and endothelial progenitor cells that are involved in angiogenesis. It also enhances tumor cell proliferation and migration. Metformin, type II diabetes medication, demonstrates anticancer properties via suppressing inflammation, tumor cell proliferation, angiogenesis, and metastasis. This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration. Our data indicated that metformin suppressed LPS-induced CXC

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Iwata, Ryoichi, Masato Maruyama, Tomoki Ito, et al. "Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor." Medical Molecular Morphology 50, no. 4 (2017): 211–19. http://dx.doi.org/10.1007/s00795-017-0160-0.

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Chunharojrith, Paweena, Yuki Nakayama, Xiaobing Jiang, et al. "Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line." Molecular and Cellular Endocrinology 416 (November 2015): 27–35. http://dx.doi.org/10.1016/j.mce.2015.08.018.

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Stern, Linda, Manuela Palatsides, Theonne De Kretser, and Miriam Ford. "Expression of the tumor-associated mucin MUCI in an ovarian tumor cell line." International Journal of Cancer 50, no. 5 (1992): 783–90. http://dx.doi.org/10.1002/ijc.2910500520.

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Goldstein, Matthew J., Bindu Varghese, Ranjani Rajapaksa, Joshua Brody, Shoshana Levy, and Ronald Levy. "Adoptive Cell Therapy for Lymphoma: Use of CpG-Loaded Tumor Cells to Generate Potent Anti-Tumor CD4 T Cell Immunity." Blood 114, no. 22 (2009): 929. http://dx.doi.org/10.1182/blood.v114.22.929.929.

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Abstract Abstract 929 Background: Recently, we have investigated adoptive cell therapy for treating lymphoma. The efficacy of this maneuver has been demonstrated by curing large established tumors. Specifically, we use active immunization to generate anti-tumor T cells in vivo and transfer these T cells into lymphodepleted recipient mice (Brody J, Goldstein MJ, Czerwinski DK, and Levy R; Blood, 2009). A major challenge in adoptive therapy is the method of generating anti-tumor T cells. Traditionally, tumor-specific T cells are expanded to large numbers ex vivo. Herein, we describe a new, whole

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Miserocchi, Giacomo, Alessandro De Vita, Laura Mercatali, et al. "Characterization and Drug Sensitivity of a New High-Grade Myxofibrosarcoma Cell Line." Cells 7, no. 11 (2018): 186. http://dx.doi.org/10.3390/cells7110186.

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Myxofibrosarcoma (MFS) belongs to the group of sarcoma tumors, which represent only 1% of the totality of adult tumors worldwide. Thus, given the rare nature of this cancer, this makes the availability of MFS cell lines difficult. In an attempt to partially fill this gap, we immortalized a primary culture of MFS (IM-MFS-1) and compared the cell morphology with patient’s tumor tissue. IM-MFS-1 was genetically characterized through a Comparative Genomic Hybridization (CGH) array and the mesenchymal phenotype was evaluated using Polymerase chain reaction (PCR) and immunofluorescence staining. Dru

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Tienari, Jukka, Ilkka Reima, Marcelo L. Larramendy, et al. "A cloned human germ cell tumor-derived cell line differentiating in culture." International Journal of Cancer 77, no. 5 (1998): 710–19. http://dx.doi.org/10.1002/(sici)1097-0215(19980831)77:5<710::aid-ijc9>3.0.co;2-y.

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ISHIGURO, Taketo, Tsuyoshi KADOSAWA, Koshi MORI, Satoshi TAKAGI, Masahiro OKUMURA, and Toru FUJINAGA. "Establishment and Characterization of a New Canine Mast Cell Tumor Cell Line." Journal of Veterinary Medical Science 63, no. 9 (2001): 1031–34. http://dx.doi.org/10.1292/jvms.63.1031.

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Sugimoto, Tohru, Hajime Hosoi, Yoshihiro Horii, et al. "Malignant rhabdoid-tumor cell line showing neural and smooth-muscle-cell phenotypes." International Journal of Cancer 82, no. 5 (1999): 678–86. http://dx.doi.org/10.1002/(sici)1097-0215(19990827)82:5<678::aid-ijc10>3.0.co;2-k.

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Surikova, Ekaterina Igorevna, Elena Frantsiyants, Irina A. Goroshinskaya, et al. "Does signet-ring cell carcinoma of the stomach (SRCC) need stimulation of neoangiogenesis?" Journal of Clinical Oncology 36, no. 4_suppl (2018): 33. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.33.

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33 Background: Tumor neoangiogenesis is a complex coordinated process involving various regulatory molecules. Vascular endothelial growth factors, in particular VEGF-A, are important effectors. A multipotent TGF-β1 cytokine can modulate stromal angiogenesis reactions promoting the tumor growth. Our purpose was to study the function of the system of pro-angiogenic cytokines in tissues of stomach tumors of various histological types - adenocarcinoma (AC) and signet-ring cell carcinoma (SRCC). Methods: The concentrations of VEGF-A, VEGF-R1 and TGF-β1 were studied by ELISA in tumors, peritumoral z

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Michishita, Masaki, Shiori Ezaki, Kikumi Ogihara, et al. "Identification of tumor-initiating cells in a canine hepatocellular carcinoma cell line." Research in Veterinary Science 96, no. 2 (2014): 315–22. http://dx.doi.org/10.1016/j.rvsc.2014.01.004.

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Kuzminov, A. Ye, K. K. Laktionov, A. A. Yegorova, V. V. Breder, and T. D. Barbolina. "Immunotherapy for small-cell lung cancer." Medical Council, no. 10 (June 24, 2019): 22–27. http://dx.doi.org/10.21518/2079-701x-2019-10-22-27.

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Small-cell lung cancer (SCLC) is one of the most prognostically unfavorable malignant tumors for which an effective targeted inhibitor has not yet been found. Cytotoxic therapy for SCLC has not changed in the last thirty years. Immunotherapy is a fundamentally new method of treatment of malignant tumors, which has proven its effectiveness in various solid tumors. Fundamental prerequisites for the efficacy of immunotherapy in SCLC include a high level of mutational load and paraneoplastic syndromes typical for SCLC (Lambert - Eaton syndrome, etc.), leading to immunization against the tumor; fac

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Hodge, Lucy S., Anne J. Novak, Deanna M. Grote, et al. "Establishment and characterization of a novel Waldenström macroglobulinemia cell line, MWCL-1." Blood 117, no. 19 (2011): e190-e197. http://dx.doi.org/10.1182/blood-2010-12-326868.

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Abstract Waldenström macroglobulinemia (WM) is a rare, lymphoplasmacytic lymphoma characterized by hypersecretion of immunoglobulin M (IgM) protein and tumor infiltration into the bone marrow and lymphatic tissue. Our understanding of the mechanisms driving the development and progression of WM is currently by the shortage of representative cell models available for study. We describe here the establishment of a new WM cell line, MWCL-1. Comprehensive genetic analyses have unequivocally confirmed a clonal relationship between this novel cell line and the founding tumor. MWCL-1 cells exhibit an

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