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Dissertations / Theses on the topic 'Cell line'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Gale, Zoe. "Glial cell line-derived neurotrophic factor effects on dental pulp cells and osteoblast-like cells." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3268/.

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Glial cell line-derived neurotrophic factor (GDNF) is a growth factor promoting survival, proliferation and differentiation of neural crest cells. Neural crest cells play an important role within mesenchymal tissues during dental pulp and calvarial bone development. GDNF also has a role within non-neuronal tissues and is expressed during dental development. GDNF null mutations prevent the formation of the mineralised hard tissues of the tooth. The hypothesis for this study was that GDNF affects mesenchymal dental pulp cells (DPC), promoting the regenerative responses of mineralised tissues. Th

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2

Murakami, Hiroshi. "Morphological and biological heterogeneity of three tumorigenic cell lines derived from a single p53-/- osteoblast-like cell line, MMC2." Kyoto University, 2003. http://hdl.handle.net/2433/149371.

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3

Fortunati, Jennifer L. "Development of a human plasmacytoma cell line with inducible expression of activated B-cell factor-1." Scholarly Commons, 2004. https://scholarlycommons.pacific.edu/uop_etds/594.

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The basic helix-loop-helix protein, activated B-cell factor-l (ABF-l), is a transcription factor involved in cellular proliferation and differentiation. ABF-1 shows patterns of expression that are stimulated in activated B cells, which may suggest ABF-1 is involved in the regulation of B-cell differentiation. To investigate the functional role of ABF-1, we have generated a human plasmacytoma cell line with inducible expression of ABF-1. We were able to induce expression of ABF-1 by using the tetracycline repressor system (teton/off). With addition of tetracycline we were able to stimulate the

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4

Richmond, Jennifer Mary. "Development of a Burkitt Lymphoma cell line with inducible expression of activated B-cell factor-1." Scholarly Commons, 2004. https://scholarlycommons.pacific.edu/uop_etds/595.

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Activated B-cell Factor-I (ABF-1) is a class II basic helix-loop-helix protein expressed in activated B-cells, EBV -immortalized lymphoblastoid cell lines and embryonic skeletal muscle in mice. ABF -1 dimerizes with another bHLH protein E4 7 to form a transcriptional repressor ofE2A, which is a gene essential to the proper development of B- and T -cells. In an effort to study genes in B-cells regulated by ABF- 1, I have attempted to construct a Burkitt Lymphoma cell line allowing tetracycline regulated expression of ABF-1. The tetracycline repressor gene was first added to these cells, creatin

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5

Cartwright, Joseph. "CHO cell genetic instability : from transfection to stable cell line." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/13986/.

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Chinese hamster ovary (CHO) cells are the predominant host cell type used in the production of recombinant therapeutic proteins. They are chosen as hosts, because of their ability to create, fold and modify proteins in a manner that makes them compatible with the human immune system. Moreover, CHO cells are tried and tested model organisms for bioprocess platforms, meaning regulatory body approval for new therapeutics is relatively easy to achieve. CHO cells are inherently genetically unstable, which can lead to a decline in productivity and poses a threat to product quality heterogeneity of s

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6

Belbaraka, Loubaba. "Growth, differentiation and cell-cell coupling in the human neuroblastoma cell line SH-SY5Y." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6112.

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Neuroblastoma is one of the most common paediatric solid tumours, frequently occurring in infancy with the primary lesion in the adrenal gland and sympathetic nervous system. It originates from primitive neural crest cells. In rare cases, this tumour regresses spontaneously to a more benign ganglioneuroma probably by neuronal differentiation or apoptosis. We investigated the role of induction of neuronal differentiation and apoptosis in vitro in SH-SY5Y neuroblastoma cells. A variety of agents that are known to induce neuronal differentiation including retinoic acid, nerve growth factor (NGF),

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7

Guest, R. D. "The human lymphoblastoma cell line AHH-1." Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637185.

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The human lymphoblastoid cell line AHH-1 (which expresses CYP1A1) and the metabolically competent derivative MCL-5 (which expresses CYP1A2, 2A6, 2E1, 3A4 and epoxide hydrolase), have been shown to be capable of detecting a variety of pro-genotoxins in the <I>in vitro</I> binucleate micronucleus assay. In these studies, it was possible to identify the inducibility of micronuclei by: tobacco particular matter (TPM); diesel particulate matter (DPM); "Sea Empress" slick oil; and crude oil using the binucleate micronucleus assay. A positive increase in micronuclei in mammalian binucleate cells was

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8

Twomey, Ciara. "Ribozyme delivery into the 32Db3a2 cell line." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323247.

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9

Ngantung, Frederyk Anthonius. "Engineering mammalian cell line to improve sialylation." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33719.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Includes bibliographical references (p. 209-231).<br>One of the key problems faced by many biotechnology companies is the cleavage of terminal sialic acid on the glycans of the therapeutic glycoproteins. This is caused by the degradative action of sialidase released to supernatant when the cell starts to die. This phenomenon is undesirable because the loss of terminal sialic acid results in a product which is rapidly removed from the plasma by the interaction with asialoglycoprotein receptors in the

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10

Betts, J. P. J. "Incorporation of developability into cell line selection." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1467250/.

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The pharmaceutical industry is under increasing pressure to deliver new medicines quickly and cost effectively; traditional small molecule product pipelines have dried up and companies are increasingly investing into biopharmaceuticals. To date, the most successful biopharmaceuticals have been monoclonal antibodies. The ability to construct common manufacturing platforms for a range of antibody products has underpinned this interest. Antibodies are most often produced as heterologous proteins at large scale in stirred tank reactors. However, at manufacturing scale there is limited opportunity

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11

Safrany, Stephen T. "Phosphoinositide signalling in a neuroblastoma cell line." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/33612.

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In the studies described in this thesis, the ability of muscarinic agonists to initiate phosphoinositide metabolism, subsequently leading to the mobilisation of Ca2+ from intracellular stores was examined in permeabilised human neuroblastoma SH-SY5Y cells. Muscarinic receptors, determined as being of the M3 subtype, were found to possess different levels of receptor reserve for the production of the second messenger, inositol 1,4,5-trisphosphate (Ins(l,4,5)P3) and the mobilisation of Ca2+ in this permeabilised cell preparation. The effects of agonist pretreatment of intact cells with the musca

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12

Blair, Tesha E. "The Apoptotic and Inhibitory Effects of Phylloquinone in the U937 Cell Line." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3028.

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Phylloquinone is a natural analog of vitamin K that has been shown to both inhibit cancer cell growth and induce apoptosis in several cancer cell lines. This study examined these effects in a non-Hodgkin lymphoma cell line, known as U937. Cell growth inhibition and apoptosis were assessed through the quantification of cell density and area, following treatment with several concentrations of phylloquinone. In addition, apoptosis was detected and quantified using immunofluorescent markers of apoptosis (i.e. annexin V, APO-BrdU). Treatment with phylloquinone resulted in reduced overall cell densi

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13

Faraday, David Brian Foster. "The mathematical modelling of the cell cycle of a hybridoma cell line." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341620.

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14

Orchard, Craig Brailsford. "Relationship between programmed cell death and the cell cycle in the tobacco BY-2 cell line." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55931/.

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Ethylene is an established plant growth regulator linked with programmed cell death (PCD). To investigate the relationship between the cell cycle and PCD, ethylene was used to see if it induced mortality in a cell cycle specific manner. Tobacco BY-2 cultures synchronized with aphidicolin were treated with ethylene. Cell cycle progression and mortality, measured at hourly intervals, showed distinct peaks of mortality at the G2/M boundary and S-phase. In conjunction with this, DNA fragmentation increased at G2/M. Furthermore, ethylene caused a significant reduction in cell size of the cycling po

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15

Chang, Colin A. "Glutathione release from an airway epithelian cell line." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19433.

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Glutathione (GSH) is the most abundant antioxidant in the lung and plays an important protective role. The level of GSH in the airway surface liquid (ASL) is significantly reduced in cystic fibrosis (CF) patients, which may exacerbate the oxidative stress in the airway lumen induced by inflammation. GSH release may also be harmful to surface cells lining the airways if it reduces intracellular levels. The mechanisms of glutathione transport by airway epithelia are not known.

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16

Xu, Chenjia. "A Novel in vitro PDE7 Inhibitor Inhibits IL-2 Gene Expression in Activated T Cells and Induces Apoptosis in a B-cell Line and Monocytic Cell Line." Thesis, Boston College, 2013. http://hdl.handle.net/2345/3935.

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Thesis advisor: Thomas C. Chiles<br>Elevating intracellular cAMP levels can result in a wide range of anti-inflammatory effects and growth arrest and apoptosis in cancer cells, marking phosphodiesterases (PDEs) as potential targets for inflammatory diseases and cancer treatment. PDE7A is proposed to be a new therapeutic target for its ubiquitous expression in proinflammatory and immune cells. A Barbituric acid based compound, BC12 was identified as an in vitro PDE7 inhibitor in fission-yeast-based high-throughput screen. Analysis of this compound on the activation of Jurkat T lymphocytes, mous

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17

Kaichi, Shinji. "Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice." Kyoto University, 2010. http://hdl.handle.net/2433/131916.

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18

Dwivedi, Amrita. "Regulation of cell adhesion molecule expression in the endothelial cell line EA.hy 926." Thesis, Oxford Brookes University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325504.

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19

Wyant, Timothy Lewis 1965. "The generation of a murine mesangial cell line deficient in AE2 expression: Introduction of human AE1 into a murine cell line." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290615.

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Senescent cell antigen (SCA) is an antigen that was first identified on human erythrocytes. The formation of SCA is a normal cellular process which marks cells as old and/or damaged. This has been clearly demonstrated in the erythrocyte systems and is believed to occur in other cell types. SCA is formed from the breakdown of the major anion transport protein (Anion Exchanger, AE, or band 3). The mechanism for the formation of SCA is currently not understood. Research into the formation of SCA has been hampered by lack of in vitro models that allow the manipulation of the AE protein. Here, we d

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20

Vanhee, Christine. "Influence of shear stress on cell proliferation and on protein kinase C localization in an anchorage-dependent mammalian cell line." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/18866.

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21

Löhr, Janine [Verfasser]. "Stem Cell Features in Spheroids and Standard Culture of a Renal Cell Carcinoma Cell Line / Janine Löhr." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1212435508/34.

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22

Robinson, Susan Kathleen. "Investigations of CHO 1-15 and Silk Gland Cell Line Development." DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/3690.

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The BioProcessing Demonstration and Training Laboratory was established with a collaboration between Utah State University and Thermo Fisher- Scientific, Inc. This lab was developed into a fully functioning tissue culture facility. Demonstration of tissue culture procedures were necessary for the lab to be industry-fully qualified. The CHO 1-15 cell line protocols were optimized by establishing conditions for reproducibility in shaker flasks and bioreactors (2 to 250 L capacity). CHO 1-15 is the cell line of choice for protein production in the bio-manufacturing industry. Oxidative stress is a

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23

Lio, Yi-Ching. "Characterization of a Ca²⁺-independent phospholipase A₂ from the macrophage-like cell line P388D₁ /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9732710.

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24

Ritter, Marie [Verfasser]. "Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent / Marie Ritter." Köln : Deutsche Zentralbibliothek für Medizin, 2017. http://d-nb.info/1147491151/34.

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25

Billings, Raewyn Lorraine. "Simulating human tumour heterogeneity using cancer cell line mixtures." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51252.

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Tumours comprise (epi)genetically and phenotypically diverse cellular subpopulations evolving over space and time. This heterogeneity can be observed as differences in morphology or immunohistology of tumour sections, gene expression levels, genomic sequence and structure, proliferative potential, or metastatic ability. In order to unravel how this heterogeneity persists, one may study the clonal structure and evolution of tumours. Understanding intra-tumor heterogeneity, or the differences amongst cells in a single tumour, is of particular importance to facilitate treatment combinations

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26

Killey, Jennifer. "Volume-activated chloride currents in a cancer cell line." Thesis, University of Huddersfield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247398.

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27

Lycett, Gareth John. "DNA transfection of an Ades aegypti mosquito cell line." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314572.

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28

Elrick, Lucy Joanne. "Properties and functions of a human islet cell line." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395049.

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A major goal for the treatment of diabetes is the generation of a replenishable source of human β-cells for transplantation. A study of PHHI identified a β-like cell line that could grow and divided in culture and expressed detectable levels of insulin. Firstly this study has characterised the properties and functions of the Nes2Y(P) cell in terms of insulin expression and β-cell phenotype, by RT-PCR and immunocytochemistry. Nes2Y(P) cells could proliferate both rapidly and indefinitely in culture. Major β-cell phenotypic markers including GLUT2, NeuroD and Nkx6.1 were also detected. Insulin e

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29

Boullier, Brian Antony. "Deoxycytidine kinase deficiency in a Friend erythroleukaemia cell line." Thesis, University of Ulster, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328194.

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30

Luxemburg, Michael, and Hanna Jönsson. "Quantum Dot Movement on Human Lung Epithelial Cell Line." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-195672.

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Inhalationsläkemedel är den främsta behandlingsmetoden för lungsjukdomar såsom astma och KOL. Förutom medicinering inandas vi dessutom miljardtals luftmolekyler varje dag varav en del är föroreningar. Hur dessa ämnen påverkar lunghälsan beror i hög grad på spridningen över lungcellerna. För att mediciner ska absorberas effektivt och luftföroreningar inte ska fastna och ackumuleras, krävs ett funktionellt transportsystem över lungcellerna såsom cellernas cilier. Denna studie ämnar undersöka kvantpartiklars spridning på lungceller utsatta för olika förhållanden som har visats påverka ciliers mob

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31

Pinto, Tiago José de Assunção Carvalho e. Pedrosa. "Evaluation of cadmium induced cytotoxicity in osteosarcoma cell line." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/8040.

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Mestrado em Biologia Aplicada - Biologia Molecular e Celular<br>Cadmium exerts harmful effect on public health. Environmental and occupational exposure, are the two main ways for human exposure. It was also shown that even low levels of cadmium exposure can leave to renal and other organs failure. Exposure to cadmium is associated with various bone problems and diseases like bone loss, fragilization and osteoporosis. Moreover, it was reported that cadmium exposure may perturb calcium homeostasis, Vitamin D formation and interact directly on bone metabolism. Reactive oxygen species have an imp

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32

Levy, Anita Rochelle. "Progestin receptor heterogeneity in a breast cancer cell line." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1004100.

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Anti-oestrogens act via the oestrogen receptor whether they compete with the hormone for binding to the receptor and therefore interfere with DNA binding or inhibit transcriptional activity. These receptors exist as a large 85 complex and/or a small 45 form on sucrose density gradients. High performance ion-exchange chromatography has confirmed that the oestrogen and progestin complex is present in various isoforms. Progestin receptor heterogeneity could be influenced by the presence of oestrogens and anti-oestrogens in the culture media of hormone-dependent neoplastic cells. Cell culture meth

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33

Egawa, Haruto. "Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells." Kyoto University, 2004. http://hdl.handle.net/2433/147458.

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34

"Proteomic studies on anti-proliferating activities of adenosine and cordycepin in human cancer cell lines." 2004. http://library.cuhk.edu.hk/record=b5892133.

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Tam Wai-Kwan Karen.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (leaves 109-128).<br>Abstracts in English and Chinese.<br>Thesis committee --- p.i<br>Statement --- p.ii<br>Abstract --- p.iii<br>Acknowledgements --- p.vi<br>Abbreviations --- p.vii<br>Table of Contents --- p.ix<br>List of Tables --- p.xii<br>List of Figures --- p.xiv<br>Chapter 1. --- Introduction --- p.1<br>Chapter 2. --- Literature Review --- p.2<br>Chapter 2.1 --- Introduction of Cordyceps --- p.2<br>Chapter 2.2 --- Pharmacological functions of Cordyceps --- p

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35

Chou, Tsung-Yu, and 周宗佑. "The effect of the fungal immunomodulatory protein on human leukemia cell line, Jurkat cell line." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/42380232578063105385.

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碩士<br>國立高雄海洋科技大學<br>海洋生物技術研究所<br>98<br>Leukemia caused by the abnormal proliferation of leukocytes cells, is one of the most common malignant disease in children. The fungal immunomodulatory protein (FIP) is purified from Ganoderma tsugae mycelia. Several studies have shown that FIP can significantly reduce proliferation of cancer cell. Our previous study showed that the inhibition of HL-60 cancer cell by FIP through the increase of free radical. In present study, our results showed that FIP can inhibit the growth of Jurkat cancer cell, and induce several apoptosis features, such as apoptotic

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36

Yang, Wei Cheng, and 楊維正. "Establishment of specific embryonic stem cell line derived T cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/06649319872420994834.

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碩士<br>長庚大學<br>醫學生物技術研究所<br>96<br>Embryonic stem (ES) cells are cells isolated from inner cell mass of blastocyst and preserved the potential of differentiating into cells of three germ layers when they are cultured under specified conditions. Recent studies showed that ES cells are capable of differentiating into lymphoid T lineage cells when co-cultured with a Notch receptor ligand, Delta-like 1, expressing bone marrow stromal cell line, OP9-DL1, with Flt3L and IL-7 supplement. By transferring these induced T progenitors could successfully reconstitute the defect immune system in immune compr

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37

Rong, Chen Yih, and 陳議榮. "Photolithographic Cell Control: Off-Line and In-Line Stepper Coordinator." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/84876132252916296680.

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碩士<br>國立臺灣科技大學<br>工程技術研究所<br>84<br>Generic Equipment Control, of semiconductor manufacturing fab, that allows control of multiple equipment at the same time, is made possible under the premise that individual equipment operational scenario can be {\it normalized} by its equipment driver. However, scenario normalization for a stepper in particular in photolithographic cell is complicated due to the fact that: (1) the lack of ready cassette input/output ports in providing pertinent material m

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38

Wang, Hsin-En, та 王信恩. "The Study of TGF-β Signaling in Normal Fibroblast Cell Line And Keloid Fibroblast Cell Line". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/43985766077127874123.

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碩士<br>高雄醫學大學<br>醫學研究所<br>91<br>Abstract:Keloid is one of the most common skin disease in human beings.Which defined as scars growing beyond the confines of original woundsafter healing of a skin injury. There is no universally accepted effective treatment, with the conventional therapy, i.e. surgery and/or intralesional steroid injection，the recurrence rate is 50﹪.The pathogenesis is still unknow. The abnormalities in extracellular matrix collagen production, abnormal response of the fibroblasts to various cytokines and the signal transduction might be the important factors. TGF-β

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39

Wu, Shan-Ying, and 吳珊瑩. "The molecular mechanisms of curcumin-induced cell cycle arrest and apoptosis in NPC 076 cell line and SCC-4 cell line." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/76200829272420493293.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>95<br>Curcumin(bis（4-hydroxy-3-methoxy-phenyl）-1,6-diene -3,5-dione), one of the most studied chemopreventive agents, is a natural compound extracted from the root of the plant Curcuma that allows suppression, retardation or inversion of carcinogenesis and treatment of different inflammatory diseases in traditional Chinese medicine for thousands of years. The active component of turmeric responsible for this activity, curcumin, was identified almost two centuries ago. Curcumin is also described as an anti-tumoral, antioxidant and anti-inflammatory agent capable of in

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CHIANG, CHEN PO, and 陳柏江. "Cloning and characterization of priB-like gene from human cell line." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/94356219407388781085.

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碩士<br>國立成功大學<br>生物化學研究所<br>88<br>The product of priB, initially called the n protein, was identified biochemically as one of the proteins which are necessary for the assembly of the DNA primosomal protein complex. The assembly of the primosome requires seven proteins to provide the priming activity for complementary strand DNA synthesis in initiation of ψX174 bacteriophage DNA replication and DNA lagging strand. In vitro, PriB binds to the PriA-ssDNA SSB complex. It both stabilizes PriA at PAS and facilitates the binding of DnaT. However, no direct evidence for the role of PriB in replication

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41

Huang, Hsun-Yi, and 黃薰儀. "CYL-418b suppresses LPS-induced activation of macrophage-like cell line." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/19529172525102892705.

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碩士<br>中國醫藥大學<br>醫學研究所碩士班<br>95<br>Proinflammatory factors, such as nitric oxide (NO) and cytokines (TNF-??, IL-12, IFN-??, …etc.) can be induced by over activated macrophages. Recent studies have shown that large amount of NO produced by inducible NOS (iNOS, type Ⅱ) is associated with the incidence of several diseases, such as multiple sclerosis, septic shock and Alzheimer’s disease. In this study, we have found that a synthetic derivative of 9-phenoxyacridine, CYL-418b, can effectively block LPS-induced NO, COX-2, and TNF-?? production in murine macrophages (RAW 264.7). The inhibition of NO p

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42

Chen, Yi-Hsien, and 陳易賢. "Selenium Modulation of Cell Differentiation and Tumorigenicity of Hepatoma Cell Line." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/97102112047279671711.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>91<br>The trace element selenium has been shown to possess cancer-preventive activity in both animal models and humans, but the exact molecular mechanisms are debatable. It is widely accepted that multiple pathways are involved in selenium-induced chemoprevention. Previously we demonstrated that selenium is able to prevent serum-withdrawal induced apoptosis and to elicit serum-independent autonomous growth of a hepatocarcinoma (HCC) cell line, HuH7. The survival effect seems to involve FAK-PI3K-Akt pathway. As demonstrated by a microarray anal

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43

Chen, Hsien-Yu, and 陳憲煜. "Cell Differentiation Effect of Phenylacetylamino Acid on HL-60 Cell Line." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/71034751097080955025.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>87<br>A series of phenylacetylamino acid derivatives were tested for the synergistic effects with all-trans-retinoic acid ( RA ) on inducing human promyelocytic leukemia ( HL-60 ) cells differentiation. We also established the structure-activity relationships ( SARs ). On the other hand, we found that compounds which were effective in the inducing cell differentiation could also inhibit cell proliferation. Furthermore, we observed the effect on the DNA content of these compounds by flow cytometry ( FACS ). Most of these compounds were inhibited in the S ph

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Jia-Peng and 潘家鵬. "The susceptibility of UVB in human skin keratinocyte cell line (HaCaT) and Basal cell carcinoma cell line (BCC), role of DNA repair mechanisms." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/16793462825653760880.

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碩士<br>中山醫學大學<br>生物醫學科學學系碩士班<br>100<br>Exposition of solar ultraviolet (UV) radiation has been identified as one of the major risk factors for skin cancer development in Americans. UV radiation induces two of the most abundant mutagenic and cytotoxic DNA lesions such as cyclobutane–pyrimidine dimmers (CPDs) and 6-4 photoproducts (6-4PPs) and their Dewar valence isomers. However, cells have developed a number of repair mechanisms to counteract the DNA damage caused by UV. Although skin cancer is a common in Taiwan, the pathogenesis is still incompletely studied. In this proposal, we would like t

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Lee, Chia-Hsiang, and 李嘉祥. "Establishment of BACE1 FRET Reporter Cell Line." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/4ate8m.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系暨研究所<br>97<br>Alzheimer’s disease (AD) is the most common cause of dementia, affecting up to 15 million individuals worldwide. Beta-secretase (BACE1) that cleaves amyloid precursor protein (APP) to produce the amyloid 42 peptide fragment, ultimately resulting in the formation of amyloid plaques, plays a key role in the pathogenesis of AD. Thus, BACE1 is an attractive target for the development of inhibitor drugs to treat AD. Nowadays numerous in vitro BACE1 activity assay are commercially available. Our current efforts focused on the establishment of a FRET-based scr

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Lin, Run-Xiang, and 林潤庠. "Hypersensitiviy of a loach fin cell line." Thesis, 1986. http://ndltd.ncl.edu.tw/handle/06308245839519661306.

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Lin, Chia-Hui, and 林珈卉. "Characterization of HBV-producing HepAD38 cell line." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/92652135475335271672.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>104<br>Among the 2 billion global populations once infected with Hepatitis B virus (HBV), 350 million people remain HBV positive carriers. These chronic Hepatitis B (CHB) patients have high risks of developing more severe forms of liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC), with a mortality rate of 25%. More importantly, these HBV long-term carriers stay uncured, with relapses andreoccurrences, even under current anti-viral treatments. In order to find possible cure to HBV, establishing a stable HBV infection cell model system is requ

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Banfield, Bruce William. "Characterization of an alphaherpesvirus resistant cell line." Thesis, 1994. http://hdl.handle.net/2429/6875.

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A mouse L cell mutant termed gro29 has been isolated (Tufaro et al. 1987) and shown to be defective in the growth of two enveloped viruses, vesicular stom- atitis virus (VSV) and herpes simplex virus type 1 (HSV-1). In this thesis it is demonstrated that the rate of transport and processing of HSV-1 glycoproteins was impeded in infected gro29 cells. In addition, HSV-1 virions failed to exit the cell and accumulated in cytoplasmic vacuoles. The phenotype of the uninfected gro29 cell was examined. It was determined that gro29 cells were resistant to the lectins ricin and modeccin, and sho

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Chuang, Wan-Chun, and 莊婉君. "Molecular characterization of SCA8 inducible cell line." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/59967318525036138906.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>98<br>Spinocerebellar ataxia type 8 (SCA8) is an autosomal dominant late-onset neurodegenerative disease. The cause of SCA8 was originally proposed associated with CTG trinucleotide repeat at 3’UTR (untranslated region) of ATXN8OS gene, lying on chromosome 13q21. However, recent studies suggest that bidirectional transcription of ATXN8OS occurs, with its anti-strand, ataxin8 (ATXN8), which encodes a polyQ protein in the CAG orientation, and ATXN8OS transcribed into potentially pathogenic CUG transcripts. SCA8 may thus has both RNA and protein gain of function mecha

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Chuang, Hui-Chi, and 莊惠祺. "Differentiation and expansion of human Treg and Th17 cells induced by oral squamous cell carcinoma cell line." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/67106368476966420673.

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碩士<br>臺灣大學<br>微生物學研究所<br>98<br>Oral squamous-cell carcinoma (OSCC) is common worldwide with low survival rate after therapy. Previously, we found elevated Treg, Th17 and a subset of IL-17+ Foxp3+ tumor infiltrating lymphocytes (TILs) in OSCC by immunohistochemistry and flow cytometry. However, the origin of these subsets was unclear. In this study, a mixed CD4 T cells-tumor cells coculture system was established to delineate the induction and/or expansion of the IL-17+ Foxp3+ T cells. The percentage of either Foxp3+ or IL-17+Foxp3+ T cells was increased after co-cultured in the presence of an

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