Academic literature on the topic 'Cell lineage tracing'

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Journal articles on the topic "Cell lineage tracing"

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Stern, Claudio D., and Scott E. Fraser. "Tracing the lineage of tracing cell lineages." Nature Cell Biology 3, no. 9 (2001): E216—E218. http://dx.doi.org/10.1038/ncb0901-e216.

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Burgess, Darren J. "Tracing cell-lineage histories." Nature Reviews Genetics 19, no. 6 (2018): 327. http://dx.doi.org/10.1038/s41576-018-0015-0.

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Abyzov, Alexej, and Flora M. Vaccarino. "Cell Lineage Tracing and Cellular Diversity in Humans." Annual Review of Genomics and Human Genetics 21, no. 1 (2020): 101–16. http://dx.doi.org/10.1146/annurev-genom-083118-015241.

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Tracing cell lineages is fundamental for understanding the rules governing development in multicellular organisms and delineating complex biological processes involving the differentiation of multiple cell types with distinct lineage hierarchies. In humans, experimental lineage tracing is unethical, and one has to rely on natural-mutation markers that are created within cells as they proliferate and age. Recent studies have demonstrated that it is now possible to trace lineages in normal, noncancerous cells with a variety of data types using natural variations in the nuclear and mitochondrial
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Jarchum, Irene. "Tracing cell lineage with 5hmC." Nature Methods 13, no. 9 (2016): 710–11. http://dx.doi.org/10.1038/nmeth.3986.

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Wang, Lin, Zheng Yin, Wenjuan Dong, et al. "Abstract 2487: LINMAP: A framework for comprehensive cell division lineage reconstruction via molecular barcoding and machine learning." Cancer Research 85, no. 8_Supplement_1 (2025): 2487. https://doi.org/10.1158/1538-7445.am2025-2487.

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Abstract Purpose: Reconstructing cell division lineages across generations is central to understanding developmental biology, cancer progression, cell differentiation, drug resistance, and tissue aging. By integrating CRISPR-Cas9 induced gene editing with single cell RNA-Seq, high-resolution lineage tracing through molecular barcoding becomes feasible. However, tracking mutation evolution across successive guide RNA edits, especially with homing guide RNA (hgRNA) technology, poses challenges due to ongoing dynamic retargeting and genetic modifications that complicate lineage reconstruction. Me
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Liu, Kuo, Hengwei Jin, and Bin Zhou. "Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies." Journal of Biological Chemistry 295, no. 19 (2020): 6413–24. http://dx.doi.org/10.1074/jbc.rev120.011631.

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Site-specific recombinases, such as Cre, are a widely used tool for genetic lineage tracing in the fields of developmental biology, neural science, stem cell biology, and regenerative medicine. However, nonspecific cell labeling by some genetic Cre tools remains a technical limitation of this recombination system, which has resulted in data misinterpretation and led to many controversies in the scientific community. In the past decade, to enhance the specificity and precision of genetic targeting, researchers have used two or more orthogonal recombinases simultaneously for labeling cell lineag
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Yunusova, A. M., and N. R. Battulin. "Cell-marking techniques for cell lineage tracing." Vavilov Journal of Genetics and Breeding 20, no. 6 (2016): 909–17. http://dx.doi.org/10.18699/vj16.211.

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Buckingham, Margaret E., and Sigolène M. Meilhac. "Tracing Cells for Tracking Cell Lineage and Clonal Behavior." Developmental Cell 21, no. 3 (2011): 394–409. http://dx.doi.org/10.1016/j.devcel.2011.07.019.

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Kreslavsky, Taras, Annette I. Garbe, Andreas Krueger та Harald von Boehmer. "T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis". Journal of Experimental Medicine 205, № 5 (2008): 1173–86. http://dx.doi.org/10.1084/jem.20072425.

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αβ and γδ T cell lineages develop in the thymus from a common precursor. It is unclear at which stage of development commitment to these lineages takes place and in which way T cell receptor signaling contributes to the process. Recently, it was demonstrated that strong TCR signals favor γδ lineage development, whereas weaker TCR signals promote αβ lineage fate. Two models have been proposed to explain these results. The first model suggests that commitment occurs after TCR expression and TCR signaling directly instructs lymphocytes to adopt one or the other lineage fate. The second model sugg
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Burgess, Darren J. "Genome editing for cell lineage tracing." Nature Reviews Genetics 17, no. 8 (2016): 435. http://dx.doi.org/10.1038/nrg.2016.80.

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Dissertations / Theses on the topic "Cell lineage tracing"

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Zhang, Gen. "Stochastic cell fate choice from lineage tracing." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709150.

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Cesare, Gargioli. "Cell lineage tracing during Xenopus laevis tail regeneration." Thesis, University of Bath, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425270.

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RODA, NICOLO'. "SINGLE-CELL TRANSCRIPTIONAL LINEAGE TRACING REVEALS COMPLEXITY AND PLASTICITY OF BREAST CANCER PRO-METASTATIC PHENOTYPES." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/906906.

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Breast cancer (BC) represents a major clinical hurdle, with metastatic outcome accounting for poor patient prognosis. Phenotypic intra-tumor heterogeneity inversely correlates with prognosis in BC and is considered at the basis of metastatization. Traditionally, BC poly-clonal structure was investigated through the genetic barcoding of cells followed by the tracing of the offspring. However, this analysis did not allow a solid investigation of the transcriptional profile associated to clones throughout tumor progression. In this work, we exploited a recently published library of expressed ba
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Hu, Bo. "Analysis of cellular drivers of zebrafish heart regeneration by single-cell RNA sequencing and high-throughput lineage tracing." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23324.

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Das Herz eines Zebrafishs ist bemerkenswert, da es sich nach einer Verletzung vollständig regenerieren kann. Der Regenerationsprozess wird von Fibrose begleitet - der Bildung von überschüssigem Gewebe der extrazellulären Matrix (ECM). Anders als bei Säugetieren ist die Fibrose im Zebrafish nur transient. Viele Signalwege wurden identifiziert, die an der Herzregeneration beteiligt sind. Allerdings sind die Zelltypen, insbesondere Nicht-Kardiomyozyten, die für die Regulation des Regenerationsprozesses verantwortlich sind, weitgehend unbekannt. In dieser Arbeit haben wir systematisch alle Zelltyp
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Maruno, Takahisa. "Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265166.

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京都大学<br>新制・論文博士<br>博士(医学)<br>乙第13427号<br>論医博第2231号<br>新制||医||1053(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 松田 道行, 教授 渡邊 直樹, 教授 川口 義弥<br>学位規則第4条第2項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM
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Sznurkowska, Magdalena Katarzyna. "Defining lineage potential and fate behaviour of progenitors during pancreas development." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274097.

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Hu, Bo [Verfasser]. "Analysis of cellular drivers of zebrafish heart regeneration by single-cell RNA sequencing and high-throughput lineage tracing / Bo Hu." Berlin : Humboldt-Universität zu Berlin, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:11-110-18452/24021-9.

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Campbell, Callum James. "Time to quit? : non-genetic heterogeneity in cell fate propensity after DNA damage." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275600.

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Cellular checkpoints are typically considered to both facilitate the ordered execution of the cell cycle and to act as a barrier to oncogene driven cell cycles and the transmission of unresolved genetic lesions from one phase to the next. Furthermore, these mechanisms are also believed to underpin the responses of cells, both in normal and cancerous tissues, to those therapies that either directly or indirectly generate DNA damage. In recent studies however, it has become clear these checkpoints permit the passage of significant genomic aberrations into subsequent cell cycle phases and even de
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Maliken, Bryan D. B. A. "Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535375861364685.

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Thakur, Chitra [Verfasser], Ulf R. [Akademischer Betreuer] Rapp, and Thomas [Akademischer Betreuer] Rudel. "Lineage tracing of metastasis in a mouse model for Non-small cell lung cancer (NSCLC) / Chitra Thakur. Betreuer: Ulf R. Rapp ; Thomas Rudel." Würzburg : Universität Würzburg, 2012. http://d-nb.info/1111886776/34.

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Books on the topic "Cell lineage tracing"

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De Bono, Christopher, Magali Théveniau-Ruissy, and Robert G. Kelly. Cardiac fields and myocardial cell lineages. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0004.

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We focus on the origin of myocardial cells in the first and second heart fields in splanchnic mesoderm in the early embryo. Genetic lineage tracing using Cre recombinase activated conditional reporter genes has made a major contribution to our understanding of cardiac progenitor cells and will be discussed together with other experimental approaches to analysing cell lineages at the clonal level. Interactions between myocardial, epicardial and endocardial lineages are essential for coordinated function and homeostasis of the normal heart. Perturbation of heart field development and myocardial
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Meilhac, Sigolène M. Cardiac growth I: Cardiomyocyte proliferation. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0009.

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Efficient contraction of the heart depends on the size and oriented architecture of the myocardium. This is severely compromised by myocardial infarction or in cardiomyopathies. Deciphering the mechanisms underlying heart growth has attracted much attention over the past decade, after the demonstration that the mammalian heart has some potential to regenerate, thus raising hopes that heart repair may become a reality. The mechanisms of cardiac growth during development have been well studied in the mouse model, taking advantage of sophisticated genetic engineering and new tools for tracking ce
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Book chapters on the topic "Cell lineage tracing"

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Hannezo, Edouard, and Colinda L. G. J. Scheele. "A Guide Toward Multi-scale and Quantitative Branching Analysis in the Mammary Gland." In Cell Migration in Three Dimensions. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2887-4_12.

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AbstractThe mammary gland consists of a bilayered epithelial structure with an extensively branched morphology. The majority of this epithelial tree is laid down during puberty, during which actively proliferating terminal end buds repeatedly elongate and bifurcate to form the basic structure of the ductal tree. Mammary ducts consist of a basal and luminal cell layer with a multitude of identified sub-lineages within both layers. The understanding of how these different cell lineages are cooperatively driving branching morphogenesis is a problem of crossing multiple scales, as this requires in
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Jing, Yan, Patricia Simmer, and Jian Q. Feng. "Cell Lineage Tracing: Colocalization of Cell Lineage Markers with a Fluorescent Reporter." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-1028-2_18.

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Mathijs, Iris, Isabelle Houbracken, and Luc Bouwens. "Genetic Lineage Tracing of Beta Cell Neogenesis." In Animal Models in Diabetes Research. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-068-7_21.

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Spanjaard, Bastiaan, and Jan Philipp Junker. "LINNAEUS: Simultaneous Single-Cell Lineage Tracing and Cell Type Identification." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4310-5_12.

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Rempfler, Markus, Sanjeev Kumar, Valentin Stierle, Philipp Paulitschke, Bjoern Andres, and Bjoern H. Menze. "Cell Lineage Tracing in Lens-Free Microscopy Videos." In Lecture Notes in Computer Science. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-66185-8_1.

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Sashittal, Palash, Richard Y. Zhang, Benjamin K. Law, et al. "Inferring Cell Differentiation Maps from Lineage Tracing Data." In Lecture Notes in Computer Science. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-90252-9_29.

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Dumas, Laura, Jason Durand, and Karine Loulier. "Multicolor Cell Lineage Tracing Using MAGIC Markers Strategies." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4310-5_3.

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Houbracken, Isabelle, Iris Mathijs, and Luc Bouwens. "Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration." In Animal Models in Diabetes Research. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-068-7_20.

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Rodriguez Fraticelli, Alejo E., and Pedro Sánchez Sánchez. "Single-Cell Lineage Tracing and Clonal State-Fate Analysis." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4310-5_4.

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Morales-Sanchez, Abigail, Susannah C. Shissler, Jennifer E. Cowan, and Avinash Bhandoola. "Revelations in Thymic Epithelial Cell Biology and Heterogeneity from Single-Cell RNA Sequencing and Lineage Tracing Methodologies." In T-Cell Development. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2740-2_2.

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Conference papers on the topic "Cell lineage tracing"

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He, Fuyun, Shengwen Chen, Huiling Feng, and Guanglian Li. "HarD-CASDE: Segmentation And Lineage Tracking of HeLa Cells." In 2024 International Joint Conference on Neural Networks (IJCNN). IEEE, 2024. http://dx.doi.org/10.1109/ijcnn60899.2024.10650137.

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Lux, Filip, and Petr Matula. "Cell Tracking Based on Integer Linear Programming and Probability Scores." In 2024 IEEE International Symposium on Biomedical Imaging (ISBI). IEEE, 2024. http://dx.doi.org/10.1109/isbi56570.2024.10635857.

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Suherman, Adryan Fadillah, and Marwan Al-Akaidi. "Linear Actuator Performance Assessment for Solar Cell Maximum Power Tracking." In 2024 8th International Conference on Electrical, Telecommunication and Computer Engineering (ELTICOM). IEEE, 2024. https://doi.org/10.1109/elticom64085.2024.10864766.

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Hon, S., A. E. Engler, H. M. K. Richardson, and J. R. Rock. "Single Cell Sequencing and Lineage Tracing of Pulmonary Vasculature Development." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5291.

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Tian, Ye, Qiqi Sun, Sicong He, et al. "Labeling single cell for in-vivo study of cell fate mapping and lineage tracing." In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2018. http://dx.doi.org/10.1117/12.2286819.

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Piros, Sandor J. "Tracing the Immortal Strand: Cell Numbering and Lineage Representation as Wavelet Transformation." In Intelligent Systems and Control. ACTAPRESS, 2011. http://dx.doi.org/10.2316/p.2011.742-016.

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Wang, Fang, Qihan Wang, Jincheng Han, et al. "Abstract 4424: Medatree enabling single cell copy number lineage tracing and functional discovery." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-4424.

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Pantazis, Periklis. "Primed Track: Reliable Volumetric Single-cell Tracking and Lineage Tracing of Living Specimen with Dual-labeling Approaches." In Virtual 12th Light Sheet Fluorescence Microscopy Conference 2020. Royal Microscopical Society, 2020. http://dx.doi.org/10.22443/rms.lsfm2020.3.

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Francis, Anne, and Andrew Sage. "BS37 Understanding the germinal centre B cell response to atherosclerosis in mice using lineage tracing." In British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019. BMJ Publishing Group Ltd and British Cardiovascular Society, 2019. http://dx.doi.org/10.1136/heartjnl-2019-bcs.199.

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Bragt, Maaike van, Luwei Tao, and Zhe Li. "Abstract 3033: An alveolar-restricted stem cell population in the mammary luminal lineage revealed by lineage tracing serves as cells of origin of heterogeneous mammary tumors." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3033.

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Reports on the topic "Cell lineage tracing"

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Chang, Edmund. Novel Strategy for Lineage Tracing of Cancer Stem Cells by Lentiviral Barcoding. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada583773.

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Chang, Edmund C. Novel Strategy for Lineage Tracing of Cancer Stem Cells by Lentiviral Barcoding. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada549081.

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