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Relevant bibliographies by topics / Cell lineage tracing / Dissertations / Theses

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Dissertations / Theses on the topic 'Cell lineage tracing'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Zhang, Gen. "Stochastic cell fate choice from lineage tracing." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709150.

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2

Cesare, Gargioli. "Cell lineage tracing during Xenopus laevis tail regeneration." Thesis, University of Bath, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425270.

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3

RODA, NICOLO'. "SINGLE-CELL TRANSCRIPTIONAL LINEAGE TRACING REVEALS COMPLEXITY AND PLASTICITY OF BREAST CANCER PRO-METASTATIC PHENOTYPES." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/906906.

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Breast cancer (BC) represents a major clinical hurdle, with metastatic outcome accounting for poor patient prognosis. Phenotypic intra-tumor heterogeneity inversely correlates with prognosis in BC and is considered at the basis of metastatization. Traditionally, BC poly-clonal structure was investigated through the genetic barcoding of cells followed by the tracing of the offspring. However, this analysis did not allow a solid investigation of the transcriptional profile associated to clones throughout tumor progression. In this work, we exploited a recently published library of expressed ba

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4

Hu, Bo. "Analysis of cellular drivers of zebrafish heart regeneration by single-cell RNA sequencing and high-throughput lineage tracing." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23324.

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Das Herz eines Zebrafishs ist bemerkenswert, da es sich nach einer Verletzung vollständig regenerieren kann. Der Regenerationsprozess wird von Fibrose begleitet - der Bildung von überschüssigem Gewebe der extrazellulären Matrix (ECM). Anders als bei Säugetieren ist die Fibrose im Zebrafish nur transient. Viele Signalwege wurden identifiziert, die an der Herzregeneration beteiligt sind. Allerdings sind die Zelltypen, insbesondere Nicht-Kardiomyozyten, die für die Regulation des Regenerationsprozesses verantwortlich sind, weitgehend unbekannt. In dieser Arbeit haben wir systematisch alle Zelltyp

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5

Maruno, Takahisa. "Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265166.

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京都大学<br>新制・論文博士<br>博士(医学)<br>乙第13427号<br>論医博第2231号<br>新制||医||1053(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授松田道行, 教授渡邊直樹, 教授川口義弥<br>学位規則第4条第2項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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Sznurkowska, Magdalena Katarzyna. "Defining lineage potential and fate behaviour of progenitors during pancreas development." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274097.

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7

Hu, Bo [Verfasser]. "Analysis of cellular drivers of zebrafish heart regeneration by single-cell RNA sequencing and high-throughput lineage tracing / Bo Hu." Berlin : Humboldt-Universität zu Berlin, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:11-110-18452/24021-9.

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8

Campbell, Callum James. "Time to quit? : non-genetic heterogeneity in cell fate propensity after DNA damage." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275600.

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Cellular checkpoints are typically considered to both facilitate the ordered execution of the cell cycle and to act as a barrier to oncogene driven cell cycles and the transmission of unresolved genetic lesions from one phase to the next. Furthermore, these mechanisms are also believed to underpin the responses of cells, both in normal and cancerous tissues, to those therapies that either directly or indirectly generate DNA damage. In recent studies however, it has become clear these checkpoints permit the passage of significant genomic aberrations into subsequent cell cycle phases and even de

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9

Maliken, Bryan D. B. A. "Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535375861364685.

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10

Thakur, Chitra [Verfasser], Ulf R. [Akademischer Betreuer] Rapp, and Thomas [Akademischer Betreuer] Rudel. "Lineage tracing of metastasis in a mouse model for Non-small cell lung cancer (NSCLC) / Chitra Thakur. Betreuer: Ulf R. Rapp ; Thomas Rudel." Würzburg : Universität Würzburg, 2012. http://d-nb.info/1111886776/34.

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11

Carabana, Garcia Claudia. "Defining cell fate specification of mouse Mammary Stem Cells in 4D." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS055.

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SPÉCIFICATION DU DESTIN CELLULAIRE DES CELLULES SOUCHES MAMMAIRES EN 4DAu cours du développement, une coordination entre la spécification du destin cellulaire et la morphogenèse tissulaire est nécessaire à la formation des organes. Par conséquent, la façon dont différents types de cellules se différencient dans le temps et l'espace reste une question majeure en biologie du développement.La glande mammaire est constituée d'un épithélium ramifié composé d'une couche externe de cellules basales (BCs) et d'un compartiment interne de cellules luminales (LCs). Dans ce tissu, l'homéostasie adulte est

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12

Eisele, Almut. "La cinétique de différentiation des cellules souches hématopoïétiques uniques après transplantation : l´état d´équilibre et l´effet de la cytokine érythropoïétine." Thesis, Paris Sciences et Lettres (ComUE), 2019. https://tel.archives-ouvertes.fr/tel-03028817.

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La majorité des cellules de notre corps sont des cellules hématopoïétiques. Un petit nombre de cellules souches hématopoïétiques produit toutes ces cellules par divisions de maintenance and différentiation. Il a longtemps été considéré que ces cellules souches étaient une population homogène et que chaque cellule produit le même nombre et type de cellule hématopoïétique mature. Cette idée a été réfutée quand il est devenu possible de suivre la différentiation de cellules uniques. Ainsi les cellules hématopoïétiques souches individuelles produisent différents types et quantités relatives de cel

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13

Kass, Youssef Khalil. "Identification of cellular origin and molecular mechanism in basal and squamous cell carcinomas." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209771.

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Skin cancers are very common in humans. The two most frequent epithelial skin cancers are the basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). For the vast majority of cancers, the cell at the origin of tumour initiation is still unknown and assumptions concerning their origin rely mainly on morphological and immunohistochemical studies. Recently, adult stem cells (SCs) have been suggested to be at the origin of tumour initiation based on their long term self-renewing capacities. According to these, two important questions arise; do epithelial skin cancers arise from mutations

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14

Chappell, Joel. "Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274543.

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Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs proliferate and display plasticity, or whether individual cells can switch to multiple phenotypes. To assess whether proliferation and plasticity in disease is a general characteristic of VSMCs or a feature of a subset of cells, multi-colour lineage labelling is used to demonstrate that VSMCs in injury-i

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15

Moore, Preston D. "Mosaic Analysis with Double Markers (MADM) as a Method to Map Cell Fates in Adult Mouse Taste Buds." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1764.

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Taste buds are chemosensory endorgans embedded in the oral epithelium composed of cells that undergo continuous replacement. Mature taste cells live on average 10-14 days and are replaced by new cells when they die. However, the mechanism by which taste cells are produced and integrated into the taste bud as mature taste cells remains unknown. Previous studies approached this issue from either cell cycle gene expression properties or lineage tracing of precursor cells. In our study, we apply a new fate mapping technique that combines these two ideas. This technique, Mosaic Analysis with Double

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16

Smith, Jordan L. "Reversing Cancer Cell Fate: Driving Therapeutic Differentiation of Hepatoblastoma to Functional Hepatocyte-Like Cells." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1067.

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Background & Aims: Despite advances in surgical care and chemotherapeutic regimens, the five-year survival rate for Stage IV Hepatoblastoma (HB), the predominant pediatric liver tumor, remains at 27%. YAP1 and β-Catenin co-activation occurs in 80% of children’s HB; however, a lack of conditional genetic models precludes exploration of tumor maintenance and therapeutic targets. Thus, the clinical need for a targeted therapy remains unmet. Given the predominance of YAP1 and β-catenin activation in children’s tumors, I sought to evaluate YAP1 as a therapeutic target in HB. Approach & Results: Her

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17

Lin, Wey-Ran. "Tracing cell lineages in health and disease : experimental and human studies." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/556.

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This study aimed to investigate stem cell biology in the normal and diseased pancreas and liver employing robust methods for tracking stem cells and their progeny in both pre-clinical and human scenario. Bone marrow (BM) plasticity had been demonstrated in diseased organ remodelling. By detection of the Y chromosome in female mice receiving a sexmismatch BM transplantation, BM-derived cells were present in murine pancreas with cerulein-induced pancreatitis. BM-derived myofibroblasts functionally contributed to around 8% of the total population of myofibroblasts, the cells with a key fibrogenic

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18

Murdoch, Barbara. "Identification, regulation and lineage tracing of embryonic olfactory progenitors." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/994.

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Neurogenesis occurs in exclusive regions in the adult nervous system, the subventricular zone and dentate gyrus in the brain, and olfactory epithelium (OE) in the periphery. Cell replacement after death or injury, occurs to varying degrees in neural tissue, and is thought to be dependent upon the biological responses of stem and/or progenitor cells. Despite the progress made to identify adult OE and central nervous system (CNS) progenitors and lineage trace their progeny, our spatial and temporal understanding of embryonic OE neuroglial progenitors has been stalled by the paucity of identifiab

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19

Feng, Shengrui. "Lineage Tracing of Neuronal Progenitor Cells Expressing dlx1a/2a in the Zebrafish Brain." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31534.

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The Distal-less homeobox (Dlx) genes encode homeodomain transcription factors that play important roles in the development of limbs, sensory organs, branchial arches and the forebrain. In the forebrain, Dlx1 and Dlx2 are expressed in neuronal progenitor cells and play essential roles in GABAergic neuron differentiation and migration. In order to understand the fate of neuronal progenitor cells that express dlx1a/2a genes in the brain, we produced lines of Tg(dlx1a/2a:CreERT2) transgenic fish expressing the CreERT2 recombinase driven by regulatory elements from the dlx1a/2a locus. CreERT2 expre

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20

De, Gaspari Piera [Verfasser]. "Lineage tracing of Sca1-expressing cells in the heart and skeletal muscle / Piera De Gaspari." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1075454514/34.

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21

Eisenhut, Katharina [Verfasser], and Rainer [Akademischer Betreuer] Glaß. "Lineage-tracing reveals the genesis of pericytes from Nestin expressing cells during glioma angiogenesis / Katharina Eisenhut ; Betreuer: Rainer Glaß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1234389037/34.

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22

Strawbridge, Stanley Eugene. "Understanding the dynamics of embryonic stem cell differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287576.

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The two defining features of mouse embryonic stem (ES) cells are self-renewal and naive pluripotency, the ability to give rise to all cell lineages in the adult body. In addition to being a unique and interesting cell type, pluripotent ES cells have demonstrated their potential for continued advancements in biomedical science. Currently, there is an improved understanding in the chemical signals and the gene regulatory network responsible for the maintenance of ES cells in the naive pluripotent state. However, less is understood about how ES cells exit pluripotency. My main aim is to study the

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23

Wuidart, Aline. "Defining the mechanisms regulating the switch from multipotency to unipotency during mammary gland development." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/264618.

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Les cellules souches assurent le développement des tissus, leur renouvellement ainsique leur réparation suite à des blessures. L’une des questions clés du domaine de labiologie des cellules souches est l’identification des différents types cellulaires qu’unecellule souche peut donner. Les cellules souches peuvent être multipotentes, c’est-à-direcapables de donner naissance à plusieurs types cellulaires différents, ou unipotentes,c’est-à-dire qu’elles ne peuvent alors se différencier qu’en un seul type cellulaire. Lesexpériences de traçage cellulaire sont réalisées quotidiennement en biologie d

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24

Julien, Anaïs. "Rôle du muscle au cours de la régénération osseuse : étude fonctionnelle de la contribution cellulaire et impact des traumatismes musculosquelettiques Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin Role of muscle stem cells during skeletal regeneration Muscle-‐derived profibrotic progenitors impair bone healing in musculoskeletal trauma." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2170&f=15825.

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25

Lawson, Brodie Alexander James. "Cell migration and proliferation on homogeneous and non-homogeneous domains : modelling on the scale of individuals and populations." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/61066/1/Brodie_Lawson_Thesis.pdf.

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Cell migration is a behaviour critical to many key biological effects, including wound healing, cancerous cell invasion and morphogenesis, the development of an organism from an embryo. However, given that each of these situations is distinctly different and cells are extremely complicated biological objects, interest lies in more basic experiments which seek to remove conflating factors and present a less complex environment within which cell migration can be experimentally examined. These include in vitro studies like the scratch assay or circle migration assay, and ex vivo studies like t

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26

Grah, Joana Sarah. "Mathematical imaging tools in cancer research : from mitosis analysis to sparse regularisation." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273243.

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This dissertation deals with customised image analysis tools in cancer research. In the field of biomedical sciences, mathematical imaging has become crucial in order to account for advancements in technical equipment and data storage by sound mathematical methods that can process and analyse imaging data in an automated way. This thesis contributes to the development of such mathematically sound imaging models in four ways: (i) automated cell segmentation and tracking. In cancer drug development, time-lapse light microscopy experiments are conducted for performance validation. The aim is to m

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27

Thakur, Chitra. "Lineage tracing of metastasis in a mouse model for Non-small cell lung cancer (NSCLC)." Doctoral thesis, 2012. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-85420.

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Non-small cell lung cancer (NSCLC) is the deadliest form of lung cancer and has a poor prognosis due to its high rate of metastasis. Notably, metastasis is one of the leading causes of death among cancer patients. Despite the clinical importance, the cellular and molecular mechanisms that govern the initiation, establishment and progression of metastasis remain unclear. Moreover, knowledge gained on metastatic process was largely based on cultured or in vitro manipulated cells that were reintroduced into immune-compromised recipient mice. In the present study, a spontaneous metastasis mouse mo

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28

Batalha, Ana Sofia Rocha. "Investigating the role of foxj1a+ ependymal cells in zebrafish splinal cord regeneration using lineage tracing and cell ablation approaches." Master's thesis, 2017. http://hdl.handle.net/10451/27626.

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Tese de mestrado em Biologia Molecular e Genética, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2017<br>As lesões da espinal medula afectam actualmente milhões de pessoas em todo o mundo, que se deparam com um agravamento radical da sua qualidade de vida que, na maioria dos casos, não poderá ser recuperada. A Organização Mundial de Saúde define “lesão da espinal medula” como a perda total ou parcial de função neural provocada por um trauma ou uma patologia da espinal medula, resultando na diminuição do controlo motor abaixo do local da lesão assim como na perda de se

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29

Bennie, Andrew. "Lineage tracing of skeletal progenitor cells during postnatal bone formation." Thesis, 2017. https://hdl.handle.net/2144/23763.

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INTRODUCTION: Fractures represent a common orthopaedic injury and create a large financial burden for the health care system. Non-union fractures often require surgery to assist the healing process. Understanding the origin of the postnatal skeletal stem cells will allow for locally delivered therapeutic treatments to be more exactly spatially targeted for fracture healing. Two forms of post-natal bone formation were studied, callus formation after fracture and ectopic bone growth. Both forms of bone formation closely follow the mechanisms of endochondral ossification. The Prx1 gene that is kn

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30

Alves, Carolina dos Santos. "Regenerative neurogenesis in Drosophila melanogaster: The influence of age and activity in the adult brain." Master's thesis, 2017. http://hdl.handle.net/10400.12/6406.

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Dissertação de Mestrado apresentada no ISPA - Instituto Universitário para obtenção de grau de Mestre na especialidade em Neurociências Cognitivas e Comportamentais.<br>Sendo o Encéfalo um dos órgãos mais importantes do organismo, a descoberta de que o processo de neurogénese continuava presente durante a fase adulta do animal foi uma das grandes revelações científcas da última metade do século XX. Assim, uma das vantagens na investigação deste processo: Neurogénese Adulta, é a sua aplicação em diversos organismos, que posteriormente possibilitará uma compreensão mais completa e aprofundada do

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31

Nambiar, Shashank Manohar. "Lineage tracing of Ascl1-expressing cells in the maternal liver during pregnancy." Thesis, 2014. http://hdl.handle.net/1805/6016.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>To cope with the high metabolic demands of the body during pregnancy, the maternal liver adapts by increasing its mass and size. This increase is proportional to the increase in total body weight during the course of gestation. The pregnancy-induced maternal liver growth is a result of both hepatocyte hypertrophy and hyperplasia. Microarray analysis of pregnant maternal livers shows markedly different gene expression profiles when compared to a non-pregnant state. Most interesting was the 2,500-fold up-regulation in the mRNA expressi

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32

Moogk, Duane. "Live cell imaging, cell tracking and lineage analysis as a tool to investigate dynamic culture processes in heterogeneous cell systems." Thesis, 2009. http://hdl.handle.net/10012/4779.

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Live cell imaging can be used to study dynamic cellular systems at single cell resolution. In heterogeneous cell populations, analyzing cell properties at the single cell level reduces the generalization of results caused by population-based assays. This thesis details the implementation of live cell imaging and single cell tracking to characterize heterogeneous cell systems undergoing dynamic processes over multiple generations. This approach enables the consideration of both spatial and temporal variables as well as the mapping of cell phenotype trajectories along their generational linea

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33

Faria, Rita Sofia Simões. "New Perspectives on Leukemia Initiating Cell Dynamics - Redefining Concepts By Tracing Single Tumor Cell Lineages Through Barcoding Technology." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/80552.

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34

Faria, Rita Sofia Simões. "New Perspectives on Leukemia Initiating Cell Dynamics - Redefining Concepts By Tracing Single Tumor Cell Lineages Through Barcoding Technology." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/80552.

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35

Barnet, Matthew Edward. "Dynamics of Sea Urchin Gastrulation Revealed by Tracking Cells of Diverse Lineage and Regulatory State." Thesis, 2011. https://thesis.library.caltech.edu/6146/1/Thesis-Barnet_20101021.pdf.

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During gastrulation in the sea urchin embryo the archenteron, or primitive gut, is formed by an initial process of invagination at the vegetal pole of the embryo, followed by extension across the blastocoel toward the future mouth. Neither the genetic basis of gastrulation nor the detailed movement of the cells involved in archenteron formation is well understood. This thesis describes a new 4D imaging methodology by which embryonic lineage and gene regulatory states can be connected to cell behavior by tracking individual cells of the living embryo through developmental time. The work present

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Řadová, Marie. "Sledování buněčných populací z regresivních zubních primordií během ontogeneze." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-321117.

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(v anglickém jazyce) Development of tooth primordia in mice is an important model for study of odontogenesis. Several dental rudiments develop during the mouse embryogenesis. These structures develop in functional teeth in their phylogenetically older relatives. Similarly, we can initiate growth of teeth from these germs in some mutant mice. In my diploma thesis we have focused on the importance of rudimentary structures with odontogenic potential in postnatal individuals. As a model of development, we have chosen a cell population originating from rudimentary primordia MS (mesial segment) tha

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