Relevant bibliographies by topics / Cell-mediated gene therapy

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Cell-mediated gene therapy'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Cell-mediated gene therapy"

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Rosenblum, Warren D., Won H. Lee, and Michael T. Lotze. "Dendritic cell mediated gene therapy in cardiac transplantation." Journal of Cardiac Failure 5, no. 3 (1999): 26. http://dx.doi.org/10.1016/s1071-9164(99)91438-0.

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Yong, Seok-Beom, Jee Young Chung, Yoonsung Song, and Yong-Hee Kim. "Recent challenges and advances in genetically-engineered cell therapy." Journal of Pharmaceutical Investigation 48, no. 2 (2017): 199–208. http://dx.doi.org/10.1007/s40005-017-0381-1.

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Abstract Cells naturally sense and actively response to their environment. Cell-therapy has long been studied and shown therapeutic effects in various diseases. However, several hurdles should be overcome to improve cell-based therapy. Gene delivery-mediated cellular modification has shown improvement of cell function by obstacle gene silencing and therapeutic gene expression. Especially, CRISPR/Cas9-mediated genome editing is a very promising method for gene modification. In this review, we describe the recent advances in genetic modification for cell therapy. Stem cells are still promising s
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Saeed, A., I. H. Tarner, C. F. Michael, et al. "T-cell mediated gene therapy for CIED in mice." Journal of Allergy and Clinical Immunology 111, no. 2 (2003): S263. http://dx.doi.org/10.1016/s0091-6749(03)80940-5.

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Aboody, K. S., J. Najbauer, and M. K. Danks. "Stem and progenitor cell-mediated tumor selective gene therapy." Gene Therapy 15, no. 10 (2008): 739–52. http://dx.doi.org/10.1038/gt.2008.41.

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Ishihara, Akikazu, and Alicia L. Bertone. "Cell-mediated and direct gene therapy for bone regeneration." Expert Opinion on Biological Therapy 12, no. 4 (2012): 411–23. http://dx.doi.org/10.1517/14712598.2012.661709.

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Wang, Xiaojie, Mark Meloche, C. Bruce Verchere, Dawei Ou, Alice Mui, and Garth L. Warnock. "Improving Islet Engraftment by Gene Therapy." Journal of Transplantation 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/594851.

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Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients, and impaired hormone modulation in the local transplanted site. Strategies using genetic modification methods through overexpression or silencing of those proteins involved in promoting
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Dwyer, Roisin M., Sonja Khan, Frank P. Barry, Timothy O'Brien, and Michael J. Kerin. "Advances in mesenchymal stem cell-mediated gene therapy for cancer." Stem Cell Research & Therapy 1, no. 3 (2010): 25. http://dx.doi.org/10.1186/scrt25.

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Aboody, K. S., J. Najbauer, and M. K. Danks. "Erratum: Stem and progenitor cell-mediated tumor selective gene therapy." Gene Therapy 15, no. 14 (2008): 1072. http://dx.doi.org/10.1038/gt.2008.106.

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Moutsatsos, Ioannis K., Gadi Turgeman, Shuanhu Zhou, et al. "Exogenously Regulated Stem Cell-Mediated Gene Therapy for Bone Regeneration." Molecular Therapy 3, no. 4 (2001): 449–61. http://dx.doi.org/10.1006/mthe.2001.0291.

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Liberatore, Concetta, Marusca Capanni, Nicola Albi, et al. "Natural Killer Cell–mediated Lysis of Autologous Cells Modified by Gene Therapy." Journal of Experimental Medicine 189, no. 12 (1999): 1855–62. http://dx.doi.org/10.1084/jem.189.12.1855.

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This study investigated the role of natural killer (NK) cells as effectors of an immune response against autologous cells modified by gene therapy. T lymphocytes were transduced with LXSN, a retroviral vector adopted for human gene therapy that carries the selectable marker gene neo, and the autologous NK response was evaluated. We found that (i) infection with LXSN makes cells susceptible to autologous NK cell–mediated lysis; (ii) expression of the neo gene is responsible for conferring susceptibility to lysis; (iii) lysis of neo-expressing cells is clonally distributed and mediated only by N
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Dissertations / Theses on the topic "Cell-mediated gene therapy"

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Langford-Smith, Alexander William Walker. "Lentiviral vector mediated haematopoietic stem cell gene therapy for mucopolysaccharidosis type IIIA." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/lentiviral-vector-mediated-haematopoietic-stem-cell-gene-therapy-for-mucopolysaccharidosis-type-iiia(89f8e108-58f3-42bb-8b80-0e0a1fe45fd7).html.

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Mucopolysaccharidosis type III (Sanfilippo) is comprised of four phenotypically similar lysosomal storage disorders (MPS IIIA-D) caused by the deficiency of enzymes that catabolise heparan sulphate (HS). Progressive accumulation of HS results in abnormal behaviour, progressive cognitive and motor impairment and death in mid-teens. There are currently no treatments for MPS III. To assess the effect of novel therapeutics in the mouse models of MPS III it is necessary to examine the effect on primary storage of HS, secondary storage and behaviour. The reported behaviour of MPS IIIA and B mice is
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Queen, Jillian May. "Viral mediated gene transfer for modification of cell signalling and remodelling in the ischaemic myocardium." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301367.

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Zeng, Yan. "T-cell mediated suppression of neuroblastoma following fractalkine gene therapy is amplified by targeted IL-2." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15401.

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Das Induzieren und Aufrechterhalten einer tumor-protektiven Immunität sind wesentliche Ziele in der Immuntherapie des Neuroblastoms. Eine Erhöhung der Anzahl von tumor-infiltrierenden Leukozyten könnte ein Weg sein, um dieses Ziel zu erreichen. Fractalkine ist ein besonderes TH1 CX3C Chemokin, welches sowohl Adhäsion und Migration von Leukozyten vermittelt. Gerichtetes IL-2 (ch14.18-IL-2) wurde durch eine genetische Fusion von anti-GD2 Antikörper mit IL-2 hergestellt, damit IL-2 spezifisch in das Mikromilieu von Neuroblastomen gebracht werden kann. In dieser Arbeit habe ich die Hypothese gete
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Wootton, Virginia. "Evaluation of lentivirus-mediated reconstitution of the B-cell compartment in XLA patient-derived CD34+ cells in humanised mice." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15864.

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X-Linked Agammaglobulinaemia (XLA) is a primary immune deficiency resulting in an absence of B-cells and antibody production due to mutations in the Bruton’s tyrosine kinase (Btk) gene. Treatment requires lifelong immunoglobulin replacement and carries significant morbidity making gene therapy an attractive possibility. The aim of this thesis was to directly test reconstitution of B-cell ontogeny in patient-derived CD34+ cells in a humanised mouse model following lentivirus-mediated gene transfer. This thesis has established a minimum non-XLA CD34+ cell dose of 0.5 x10^6 is required to reconst
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Knoop, Kerstin. "Molecular imaging and radionuclide therapy in non-thyroidal tumors after mesenchymal stem cell- mediated sodium/iodide symporter (NIS) gene transfer." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-178550.

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Tutter, Mariella [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Challenges and chances of the combination of hyperthermia with mesenchymal stem cell-mediated sodium iodide symporter gene therapy / Mariella Tutter ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1211957543/34.

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Knoop, Kerstin [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Molecular imaging and radionuclide therapy in non-thyroidal tumors after mesenchymal stem cell- mediated sodium/iodide symporter (NIS) gene transfer / Kerstin Knoop. Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1065180403/34.

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Zeng, Yan [Verfasser], H. [Gutachter] Lode, R. [Gutachter] Erttmann, and R. [Gutachter] Xiang. "T-cell mediated suppression of neuroblastoma following fractalkine gene therapy is amplified by targeted IL-2 / Yan Zeng ; Gutachter: H. Lode, R. Erttmann, R. Xiang." Berlin : Humboldt-Universität zu Berlin, 2006. http://d-nb.info/1208077031/34.

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Nicklin, Stuart Anthony. "Targeted adenovirus-mediated gene transfer to human vascular endothelium." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310591.

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Xu, Dan. "Cellular Immunity in Recombinant Adeno-Associated Virus Vector Mediated Gene Therapy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313504203.

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Book chapters on the topic "Cell-mediated gene therapy"

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Jayaraman, Megala, Parijat Dutta, Khyati Arora, et al. "Mesenchymal Stem Cell-Mediated Suicide Gene Therapy." In Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5422-0_107.

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Jayaraman, Megala, Parijat Dutta, Khyati Arora, et al. "Mesenchymal Stem Cell Mediated Suicide Gene Therapy." In Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-1247-3_107-1.

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Zhang, Lidong, and Bingliang Fang. "Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers." In Death Receptors in Cancer Therapy. Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-851-x:339.

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Altaner, Cestmir, and Ursula Altanerova. "Mesenchymal Stem Cell Exosome-Mediated Prodrug Gene Therapy for Cancer." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8922-5_6.

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Altaner, Cestmir. "Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors." In Stem Cell Therapeutics for Cancer. John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118660423.ch5.

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Bremer, Jeroen, and Peter C. van den Akker. "In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_11.

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AbstractThe genodermatosis dystrophic epidermolysis bullosa (DEB) is caused by mutations in the COL7A1 gene which encodes type VII collagen (C7). In the cutaneous basement membrane zone, C7 secures attachment of the epidermal basal keratinocyte to the papillary dermis by means of anchoring fibril formation. The complete absence of these anchoring fibrils leads to severe blistering of skin and mucosa upon the slightest friction and early mortality. To date, although preclinical advances toward therapy are promising, treatment for the disease is merely symptomatic. Therefore, research into novel
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Blits, Bas, Deniz Kirik, Harald Petry, and Stephan Hermening. "Gene Therapy for Parkinson’s Disease: AAV5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)." In Neuromethods. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2306-9_3.

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Chang, Esther H., Liang Xu, and Kathleen F. Pirollo. "Targeted p53 Gene Therapy-Mediated Radiosensitization and Chemosensitization." In Signaling Networks and Cell Cycle Control. Humana Press, 2000. https://doi.org/10.1007/978-1-59259-218-0_29.

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Sivasubramaniam, S. D., A. R. Fooks, J. Lee, G. Stacey, and A. D. Jennings. "Neurological Therapy — Adenovirus Mediated Gene Therapy in Cells of the Central Nervous System." In Animal Cell Technology. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5404-8_9.

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Mizukami, Hiroaki, Jun Mimuro, Tsukasa Ohmori, Yoichi Sakata, and Keiya Ozawa. "AAV Vector-Mediated Liver Gene Therapy and Its Implementation for Hemophilia." In Gene Therapy and Cell Therapy Through the Liver. Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55666-4_6.

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Conference papers on the topic "Cell-mediated gene therapy"

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Carson, Andrew R., Charles F. Mctiernan, Linda Lavery, et al. "Abstract 585: Treatment of squamous cell carcinoma with ultrasound and microbubble mediated gene therapy." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-585.

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Li, Jianbo, and Hao Lin. "The Role of Ion Electrophoresis in Electroporation-Mediated Molecular Delivery." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18495.

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Electroporation is a widely applied technique to deliver active molecules into the cellular compartment, to perform tasks such as gene therapy and directed stem cell differentiation, among many others. In this technique, an electric field transiently permeabilizes the cellular membrane to facilitate molecular exchange. While the permeabilization process is relatively well understood, the transport mechanisms for molecular delivery are still under debate. In this work, the role of ion electrophoresis in electroporation-mediated molecular delivery is investigated using numerical simulation. The
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Al-Mohannadi, Anjud Khamis, Sara Deola, and Ahmed Malki. "Visualization of Factor Viii with Flow-Cytometry as a tool for Novel Gene Therapy Approach in Hemophilia A." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0164.

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Haemophilia A is a genetic X-linked disorder, characterized by coagulation Factor VIII (FVIII) deficiency and leading to pathological bleedings. The disease occurs at a rate of 1 in 5000 males’ births. The treatment is the administration of plasma-derived or recombinant Factor VIII, which is expensive and leads to the development of inhibitory antibodies in around 40% of patients affected by the severe form of the disease. The disease becomes for these patients as life threatening. In new approaches to treat Haemophilia include gene therapy (GT), cells corrected through genetic modifications a
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Chen, Kok Hao, and Jong Hyun Choi. "Nanoparticle-Aptamer: An Effective Growth Inhibitor for Human Cancer Cells." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11966.

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Semiconductor nanocrystals have unique optical properties due to quantum confinement effects, and a variety of promising approaches have been devised to interface the nanomaterials with biomolecules for bioimaging and therapeutic applications. Such bio-interface can be facilitated via a DNA template for nanoparticles as oligonucleotides can mediate the aqueous-phase nucleation and capping of semiconductor nanocrystals.[1,2] Here, we report a novel scheme of synthesizing fluorescent nanocrystal quantum dots (NQDs) using DNA aptamers and the use of this biotic/abiotic nanoparticle system for gro
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Reports on the topic "Cell-mediated gene therapy"

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Petitte, James, Hefzibah Eyal-Giladi, and Malka Ginsburg. The Study of Primordial Germ Cell Development as a Tool for Gene Transfer in Chickens. United States Department of Agriculture, 1991. http://dx.doi.org/10.32747/1991.7561071.bard.

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The ability to introduce novel genetic material into the genome of commercial poultry has been impeded by a lack of kowledge regarding the origin in the early embryo of the target cell of interest, namely, the germ cell. Hence, this project investigated the emergence of primordial germ cells (PGCs) during the early development of the avian embryo to aid in efforts to produce transgenic poultry on a routine basis. The strategy was to introduce foreign DNA into the area of the unincubated embryo that is destined to give rise to the germ line. The objectives of this project were: 1) to identify a
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Coplin, David L., Shulamit Manulis, and Isaac Barash. roles Hrp-dependent effector proteins and hrp gene regulation as determinants of virulence and host-specificity in Erwinia stewartii and E. herbicola pvs. gypsophilae and betae. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7587216.bard.

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Gram-negative plant pathogenic bacteria employ specialized type-III secretion systems (TTSS) to deliver an arsenal of pathogenicity proteins directly into host cells. These secretion systems are encoded by hrp genes (for hypersensitive response and pathogenicity) and the effector proteins by so-called dsp or avr genes. The functions of effectors are to enable bacterial multiplication by damaging host cells and/or by blocking host defenses. We characterized essential hrp gene clusters in the Stewart's Wilt of maize pathogen, Pantoea stewartii subsp. stewartii (Pnss; formerly Erwinia stewartii)
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Rafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593390.bard.

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The proposed research was directed at determining the activation/binding domains and gene regulation of the PBAN-R’s thereby providing information for the design and screening of potential PBAN-R-blockers and to indicate possible ways of preventing the process from proceeding to its completion. Our specific aims included: (1) The identification of the PBAN-R binding domain by a combination of: (a) in silico modeling studies for identifying specific amino-acid side chains that are likely to be involved in binding PBAN with the receptor and; (b) bioassays to verify the modeling studies using mut
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