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Journal articles on the topic 'Cell membrane ion transport'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Dubyak, George R. "Ion homeostasis, channels, and transporters: an update on cellular mechanisms." Advances in Physiology Education 28, no. 4 (2004): 143–54. http://dx.doi.org/10.1152/advan.00046.2004.

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The steady-state maintenance of highly asymmetric concentrations of the major inorganic cations and anions is a major function of both plasma membranes and the membranes of intracellular organelles. Homeostatic regulation of these ionic gradients is critical for most functions. Due to their charge, the movements of ions across biological membranes necessarily involves facilitation by intrinsic membrane transport proteins. The functional characterization and categorization of membrane transport proteins was a major focus of cell physiological research from the 1950s through the 1980s. On the ba

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2

Martinez, J. R. "Ion Transport and Water Movement." Journal of Dental Research 66, no. 1_suppl (1987): 638–47. http://dx.doi.org/10.1177/00220345870660s106.

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Secretion of water and electrolytes in salivary glands occurs by a dual process involving the formation of a plasma-like, isotonic primary-secretion in salivary acini and its subsequent modification in salivary-ducts by the removal and addition of specific ions. The mechanisms underlying the formation of primary acinar secretion have been investigated with a number of experimental approaches such as electrophysiology, the measurement of ion transport in gland fragments and dispersed acinar cells, and the evaluation of the ionic requirements for secretion in isolated, perfused gland preparation

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3

Martinez, J. R. "Ion Transport and Water Movement." Journal of Dental Research 66, no. 2_suppl (1987): 638–47. http://dx.doi.org/10.1177/00220345870660s206.

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Secretion of water and electrolytes in salivary glands occurs by a dual process involving the formation of a plasma-like, isotonic primary-secretion in salivary acini and its subsequent modification in salivary-ducts by the removal and addition of specific ions. The mechanisms underlying the formation of primary acinar secretion have been investigated with a number of experimental approaches such as electrophysiology, the measurement of ion transport in gland fragments and dispersed acinar cells, and the evaluation of the ionic requirements for secretion in isolated, perfused gland preparation

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4

Brône, Bert, and Jan Eggermont. "PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes." American Journal of Physiology-Cell Physiology 288, no. 1 (2005): C20—C29. http://dx.doi.org/10.1152/ajpcell.00368.2004.

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PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes. Am J Physiol Cell Physiol 288: C20–C29, 2005; doi:10.1152/ajpcell.00368.2004.—The plasma membrane of epithelial cells is subdivided into two physically separated compartments known as the apical and basolateral membranes. To obtain directional transepithelial solute transport, membrane transporters (i.e., ion channels, cotransporters, exchangers, and ion pumps) need to be targeted selectively to either of these membrane domains. In addition, the transport properties of an epithelial cell will be main

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5

Bianchi, G. "Ion transport across blood cell membrane in essential hypertension." Current Opinion in Cardiology 1, no. 5 (1986): 634–40. http://dx.doi.org/10.1097/00001573-198609000-00009.

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6

Shennan, D. B., and C. A. R. Boyd. "Ion transport by the placenta: a review of membrane transport systems." Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 906, no. 3 (1987): 437–57. http://dx.doi.org/10.1016/0304-4157(87)90019-0.

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7

Kourie, Joseph I. "Interaction of reactive oxygen species with ion transport mechanisms." American Journal of Physiology-Cell Physiology 275, no. 1 (1998): C1—C24. http://dx.doi.org/10.1152/ajpcell.1998.275.1.c1.

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The use of electrophysiological and molecular biology techniques has shed light on reactive oxygen species (ROS)-induced impairment of surface and internal membranes that control cellular signaling. These deleterious effects of ROS are due to their interaction with various ion transport proteins underlying the transmembrane signal transduction, namely, 1) ion channels, such as Ca2+ channels (including voltage-sensitive L-type Ca2+currents, dihydropyridine receptor voltage sensors, ryanodine receptor Ca2+-release channels, andd- myo-inositol 1,4,5-trisphosphate receptor Ca2+-release channels),

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8

Morachevskaya, Elena A., and Anastasia V. Sudarikova. "Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus." American Journal of Physiology-Cell Physiology 320, no. 5 (2021): C696—C702. http://dx.doi.org/10.1152/ajpcell.00368.2020.

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Ion channels in plasma membrane play a principal role in different physiological processes, including cell volume regulation, signal transduction, and modulation of membrane potential in living cells. Actin-based cytoskeleton, which exists in a dynamic balance between monomeric and polymeric forms (globular and fibrillar actin), can be directly or indirectly involved in various cellular responses including modulation of ion channel activity. In this mini-review, we present an overview of the role of submembranous actin dynamics in the regulation of ion channels in excitable and nonexcitable ce

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9

Bing, Robert F., Anthony M. Heagerty, Herbert Thurston, and John D. Swales. "Ion transport in hypertension: are changes in the cell membrane responsible?" Clinical Science 71, no. 3 (1986): 225–30. http://dx.doi.org/10.1042/cs0710225.

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Disturbances in several, distinct cell membrane ion transport processes have been demonstrated in essential hypertension but their variable relationship to blood pressure in different populations has made it difficult to achieve a unifying hypothesis. We suggest that altered composition of the lipid fraction of the cell membrane is the common underlying factor. This would produce many of the reported perturbations of cell membrane properties and function, not all of which relate directly to the development of hypertension, but which act as markers for the underlying abnormality. However, funct

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10

Muallem, Shmuel, Woo Young Chung, Archana Jha, and Malini Ahuja. "Lipids at membrane contact sites: cell signaling and ion transport." EMBO reports 18, no. 11 (2017): 1893–904. http://dx.doi.org/10.15252/embr.201744331.

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11

Kirk, Kiaran. "Membrane Transport in the Malaria-Infected Erythrocyte." Physiological Reviews 81, no. 2 (2001): 495–537. http://dx.doi.org/10.1152/physrev.2001.81.2.495.

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The malaria parasite is a unicellular eukaryotic organism which, during the course of its complex life cycle, invades the red blood cells of its vertebrate host. As it grows and multiplies within its host blood cell, the parasite modifies the membrane permeability and cytosolic composition of the host cell. The intracellular parasite is enclosed within a so-called parasitophorous vacuolar membrane, tubular extensions of which radiate out into the host cell compartment. Like all eukaryote cells, the parasite has at its surface a plasma membrane, as well as having a variety of internal membrane-

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12

HAMM-ALVAREZ, SARAH F., and MICHAEL P. SHEETZ. "Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney." Physiological Reviews 78, no. 4 (1998): 1109–29. http://dx.doi.org/10.1152/physrev.1998.78.4.1109.

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Hamm-Alvarez, Sarah F., and Michael P. Sheetz. Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney. Physiol. Rev. 78: 1109–1129, 1998. — Microtubule-based vesicle transport driven by kinesin and cytoplasmic dynein motor proteins facilitates several membrane-trafficking steps including elements of endocytosis and exocytosis in many different cell types. Most early studies on the role of microtubule-dependent vesicle transport in membrane trafficking focused either on neurons or on simple cell lines. More recently, other work has considered

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13

Karle, Christoph, Tobias Gehrig, Ralf Wodopia, et al. "Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 286, no. 6 (2004): L1154—L1160. http://dx.doi.org/10.1152/ajplung.00403.2002.

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In excitable cells, hypoxia inhibits K channels, causes membrane depolarization, and initiates complex adaptive mechanisms. It is unclear whether K channels of alveolar epithelial cells reveal a similar response to hypoxia. A549 cells were exposed to hypoxia during whole cell patch-clamp measurements. Hypoxia reversibly inhibited a voltage-dependent outward current, consistent with a K current, because tetraethylamonium (TEA; 10 mM) abolished this effect; however, iberiotoxin (0.1 μM) does not. In normoxia, TEA and iberiotoxin inhibited whole cell current (−35%), whereas the K-channel inhibito

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14

Guggino, W. B., H. Oberleithner, and G. Giebisch. "Relationship between cell volume and ion transport in the early distal tubule of the Amphiuma kidney." Journal of General Physiology 86, no. 1 (1985): 31–58. http://dx.doi.org/10.1085/jgp.86.1.31.

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The roles of apical and basolateral transport mechanisms in the regulation of cell volume and the hydraulic water permeabilities (Lp) of the individual cell membranes of the Amphiuma early distal tubule (diluting segment) were evaluated using video and optical techniques as well as conventional and Cl-sensitive microelectrodes. The Lp of the apical cell membrane calculated per square centimeter of tubule is less than 3% that of the basolateral cell membrane. Calculated per square centimeter of membrane, the Lp of the apical cell membrane is less than 40% that of the basolateral cell membrane.

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15

Radenovic, Cedomir, Milos Beljanski, Georgij Maksimov, Aleksandar Kalauzi, and Milan Drazic. "The mechanism of the NH4 ion oscillatory transport across the excitable cell membrane." Zbornik Matice srpske za prirodne nauke, no. 109 (2005): 5–19. http://dx.doi.org/10.2298/zmspn0519005r.

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This paper presents results on typical oscillations of the membrane potential induced by the excitation of the cell membrane by different concentrations of the NH4Cl solution. The existence of four classes of oscillations of the membrane potential and several different single and local impulses rhythmically occurring were determined. It is known that the oscillatory processes of the membrane potential are in direct dependence on oscillatory transport processes of NH4 and Cl ions across the excitable cell membrane. A hypothesis on a possible mechanism of oscillatory transport processes of NH4 a

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16

Soybel, D. I., M. B. Davis, and L. Y. Cheung. "Characteristics of basolateral Cl- transport by gastric surface epithelium in Necturus antral mucosa." American Journal of Physiology-Gastrointestinal and Liver Physiology 264, no. 5 (1993): G910—G920. http://dx.doi.org/10.1152/ajpgi.1993.264.5.g910.

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Conventional and ion-selective microelectrodes were used to characterize transport of Cl- across the basolateral cell membranes of gastric surface epithelium in isolated preparations of gastric antrum of Necturus. Conventional, voltage-sensing electrodes were used to evaluate changes in membrane potentials and resistances during removal of Cl- from the nutrient perfusate. Liquid ion exchanger Cl(-)-selective microelectrodes were constructed and validated to measure intracellular Cl- activity (aiCl). Our data indicate that 1) aiCl (range 12-25 mM) is close to that predicted if Cl- is distribute

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17

Sakaguchi, T., G. P. Leser, and R. A. Lamb. "The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus." Journal of Cell Biology 133, no. 4 (1996): 733–47. http://dx.doi.org/10.1083/jcb.133.4.733.

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High level expression of the M2 ion channel protein of influenza virus inhibits the rate of intracellular transport of the influenza virus hemagglutinin (HA) and that of other integral membrane glycoproteins. HA coexpressed with M2 is properly folded, is not associated with GRP78-BiP, and trimerizes with the same kinetics as when HA is expressed alone. Analysis of the rate of transport of HA from the ER to the cis and medial golgi compartments and the TGN indicated that transport through the Golgi apparatus is delayed. Uncleaved HA0 was not expressed at the cell surface, and accumulation HA at

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18

Shennan, David B. "K+ and Cl− transport by mammary secretory cell apical membrane vesicles isolated from milk." Journal of Dairy Research 59, no. 3 (1992): 339–48. http://dx.doi.org/10.1017/s0022029900030612.

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SummaryThe transport of K+ (Rb+) and Cl− by membrane vesicles isolated from bovine milk has been studied using ion-exchange column chromatography. K+ (Rb+) and Cl− accumulation by the vesicles was time-dependent and was almost abolished by 0·1% Triton X-100, suggesting that uptake represents ‘real’ transport rather than binding. K+ (Rb+) uptake was influenced by the anion in solution in a manner suggesting that influx is sensitive to changes in vesicle membrane potential. Similarly, Cl− uptake was found to be sensitive to vesicle electrical potential: Cl− influx was enhanced by inside positive

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19

Stanton, B. A., and B. Kaissling. "Regulation of renal ion transport and cell growth by sodium." American Journal of Physiology-Renal Physiology 257, no. 1 (1989): F1—F10. http://dx.doi.org/10.1152/ajprenal.1989.257.1.f1.

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Intracellular sodium has been implicated in a variety of cellular processes including regulation of Na+-K+-ATPase activity, mitogen-induced cell growth, and proliferation and stimulation of Na+-K+-ATPase by aldosterone. In renal epithelial cells a rise in sodium uptake across the apical membrane increases intracellular sodium concentration, which in turn stimulates the turnover rate of Na+-K+-ATPase and thereby enhances sodium efflux across the basolateral membrane. A prolonged increase in sodium uptake causes dramatic hypertrophy and hyperplasia and a rise in the quantity of Na+-K+-ATPase in

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20

Wolosin, J. M. "Ion transport studies with H+-K+-ATPase-rich vesicles: implications for HCl secretion and parietal cell physiology." American Journal of Physiology-Gastrointestinal and Liver Physiology 248, no. 6 (1985): G595—G607. http://dx.doi.org/10.1152/ajpgi.1985.248.6.g595.

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A summary of recent studies on relations between the properties of the membrane incorporating the H+-K+-ATPase, the H+ motive force in gastric acid secretion, and the secretory state of the parietal cell is presented. Depending on tissue secretory state, two distinct H+-K+-ATPase-rich membranes predominate in tissue homogenates, the gastric microsomes derived from the intracellular tubulovesicles of the resting cell and the stimulation-associated (SA) vesicle derived from the apical membrane of the acid-secreting cell. Structural and chemical differences between both vesicular types lend suppo

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21

Heiny, Judith A., Stephen C. Cannon, and Marino DiFranco. "A four-electrode method to study dynamics of ion activity and transport in skeletal muscle fibers." Journal of General Physiology 151, no. 9 (2019): 1146–55. http://dx.doi.org/10.1085/jgp.201912398.

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Ion movements across biological membranes, driven by electrochemical gradients or active transport mechanisms, control essential cell functions. Membrane ion movements can manifest as electrogenic currents or electroneutral fluxes, and either process can alter the extracellular and/or intracellular concentration of the transported ions. Classic electrophysiological methods allow accurate measurement of membrane ion movements when the transport mechanism produces a net ionic current; however, they cannot directly measure electroneutral fluxes and do not detect any accompanying change in intrace

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22

López-Chàvez, Ernesto, Misael Solorza-Guzmàn, and Fray de Landa Castillo-Alvarado. "Molecular Simulation of Ion-Transport inside Chitosan Membranes." Advances in Science and Technology 46 (October 2006): 188–98. http://dx.doi.org/10.4028/www.scientific.net/ast.46.188.

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We have presented general ideas to develop a theoretical methodology, based on Molecular simulation and Einstein equation aimed to describe the mechanism and behavior of chitosan-membrane ion conductivity and to obtain its magnitude for different ionic species. Atomistic molecular modelling has been utilized to construct an ionic-conducting polymer electrolyte system consisting of poly(chitosan), H O 2 molecules, and + H O 3 , − OH , 2− 4 SO ions, inside of the simulation cell. The COMPASS force field was used. The simulation allows describing the mechanism of ionic conductivity along the poly

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23

Garten, Matthias, Lars D. Mosgaard, Thomas Bornschlögl, Stéphane Dieudonné, Patricia Bassereau, and Gilman E. S. Toombes. "Whole-GUV patch-clamping." Proceedings of the National Academy of Sciences 114, no. 2 (2016): 328–33. http://dx.doi.org/10.1073/pnas.1609142114.

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Studying how the membrane modulates ion channel and transporter activity is challenging because cells actively regulate membrane properties, whereas existing in vitro systems have limitations, such as residual solvent and unphysiologically high membrane tension. Cell-sized giant unilamellar vesicles (GUVs) would be ideal for in vitro electrophysiology, but efforts to measure the membrane current of intact GUVs have been unsuccessful. In this work, two challenges for obtaining the “whole-GUV” patch-clamp configuration were identified and resolved. First, unless the patch pipette and GUV pressur

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24

Cragg, Peter J. "Artificial Transmembrane Channels for Sodium and Potassium." Science Progress 85, no. 3 (2002): 219–41. http://dx.doi.org/10.3184/003685002783238780.

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Transport of alkali metals, particularly sodium and potassium, across cell membranes is an essential function performed by special proteins that enable cells to regulate inter- and extracellular ion concentrations with exceptional selectivity. The importance of these channel-forming proteins has led to researchers emulating of their structural features: an ion-specific filter and conduction at rates up to 108 ions per second. Synthetic helical and cyclic polypeptides form channels, however, the specificity of ion transport is often low. Ion-specific macrocycles have been used as filters from w

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25

Yaroslavtsev, A. B., I. A. Stenina, and D. V. Golubenko. "Membrane materials for energy production and storage." Pure and Applied Chemistry 92, no. 7 (2020): 1147–57. http://dx.doi.org/10.1515/pac-2019-1208.

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AbstractIon exchange membranes are widely used in chemical power sources, including fuel cells, redox batteries, reverse electrodialysis devices and lithium-ion batteries. The general requirements for them are high ionic conductivity and selectivity of transport processes. Heterogeneous membranes are much cheaper but less selective due to the secondary porosity with large pore size. The composition of grafted membranes is almost identical to heterogeneous ones. But they are more selective due to the lack of secondary porosity. The conductivity of ion exchange membranes can be improved by their

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26

Lang, F., G. Messner, and W. Rehwald. "Electrophysiology of sodium-coupled transport in proximal renal tubules." American Journal of Physiology-Renal Physiology 250, no. 6 (1986): F953—F962. http://dx.doi.org/10.1152/ajprenal.1986.250.6.f953.

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Effects of sodium-coupled transport on intracellular electrolytes and electrical properties of proximal renal tubule cells are described in this review. Simultaneous with addition of substrate for sodium-coupled transport to luminal perfusates, both cell membranes depolarize. The luminal cell membrane depolarizes due to opening of sodium-cotransport pathways. The depolarization of the peritubular cell membrane during sodium-coupled transport is primarily due to a circular current reentering the lumen via the paracellular pathway. The depolarization leads to a transient decrease of basolateral

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27

Stewart, GW, BE Hepworth-Jones, JN Keen, BC Dash, AC Argent, and CM Casimir. "Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes." Blood 79, no. 6 (1992): 1593–601. http://dx.doi.org/10.1182/blood.v79.6.1593.1593.

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Abstract Human red blood cells (RBCs) that are deficient in an integral membrane- associated protein (“stomatin“) of apparent molecular mass 31 Kd show a catastrophic increase in passive membrane permeability to the univalent cations Na+ and K+ and are stomatocytic in shape. We have purified this protein from normal RBC membranes and isolated a cDNA clone coding for it. The deduced protein sequence is unrelated to that of any known ion- transport-related protein. Selective solubilization studies using detergents show that while the protein is strongly associated with the phospholipid bilayer,

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Stewart, GW, BE Hepworth-Jones, JN Keen, BC Dash, AC Argent, and CM Casimir. "Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes." Blood 79, no. 6 (1992): 1593–601. http://dx.doi.org/10.1182/blood.v79.6.1593.bloodjournal7961593.

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Human red blood cells (RBCs) that are deficient in an integral membrane- associated protein (“stomatin“) of apparent molecular mass 31 Kd show a catastrophic increase in passive membrane permeability to the univalent cations Na+ and K+ and are stomatocytic in shape. We have purified this protein from normal RBC membranes and isolated a cDNA clone coding for it. The deduced protein sequence is unrelated to that of any known ion- transport-related protein. Selective solubilization studies using detergents show that while the protein is strongly associated with the phospholipid bilayer, it also b

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29

Blanchard, Maxime G., Jean-Philippe Longpré, Bernadette Wallendorff, and Jean-Yves Lapointe. "Measuring ion transport activities in Xenopus oocytes using the ion-trap technique." American Journal of Physiology-Cell Physiology 295, no. 5 (2008): C1464—C1472. http://dx.doi.org/10.1152/ajpcell.00560.2007.

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The ion-trap technique is an experimental approach allowing measurement of changes in ionic concentrations within a restricted space (the trap) comprised of a large-diameter ion-selective electrode apposed to a voltage-clamped Xenopus laevis oocyte. The technique is demonstrated with oocytes expressing the Na+/glucose cotransporter (SGLT1) using Na+- and H+-selective electrodes and with the electroneutral H+/monocarboxylate transporter (MCT1). In SGLT1-expressing oocytes, bath substrate diffused into the trap within 20 s, stimulating Na+/glucose influx, which generated a measurable decrease in

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30

GARG, RAVISH, VIJAY KUMAR, DINESH KUMAR, and S. K. CHAKARVARTI. "ELECTRICAL TRANSPORT THROUGH MICRO POROUS TRACK ETCH MEMBRANES OF SAME POROSITY." Modern Physics Letters B 26, no. 31 (2012): 1250209. http://dx.doi.org/10.1142/s0217984912502090.

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Porosity, pore size and thickness of membrane are vital factors to influence the transport phenomena through micro porous track etch membranes (TEMs) and affect the various applications like separations, drug release, flow control, bio-sensing and cell size detection etc. based on transport process. Therefore, a better understanding of transport mechanism through TEMs is required for new applications in various thrust areas like biomedical devices and packaging of foods and drugs. Transport studies of electrolytic solutions of potassium chloride, through porous polycarbonate TEMS having cylind

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31

Altenberg, G. A., M. Subramanyam, and L. Reuss. "Muscarinic stimulation of gallbladder epithelium. II. Fluid transport, cell volume, and ion permeabilities." American Journal of Physiology-Cell Physiology 265, no. 6 (1993): C1613—C1619. http://dx.doi.org/10.1152/ajpcell.1993.265.6.c1613.

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Activation of muscarinic receptors in the fluid-absorptive epithelium of the Necturus gallbladder elevates cytosolic Ca2+ concentration, transiently hyperpolarizes the cell membrane voltages, and decreases the apparent fractional resistance of the apical membrane [G. A. Altenberg, M. Subramanyam, J. S. Bergmann, K. M. Johnson, and L. Reuss. Am. J. Physiol. 265 (Cell Physiol. 34): C1604-C1612, 1993]. In these studies, we show that at the peak of the hyperpolarization both apical and basolateral membrane resistances (Ra and Rb, respectively) decreased, but in 2-3 min Ra returned to control value

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Yu, Weiqun, Puneet Khandelwal, and Gerard Apodaca. "Distinct Apical and Basolateral Membrane Requirements for Stretch-induced Membrane Traffic at the Apical Surface of Bladder Umbrella Cells." Molecular Biology of the Cell 20, no. 1 (2009): 282–95. http://dx.doi.org/10.1091/mbc.e08-04-0439.

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Epithelial cells respond to mechanical stimuli by increasing exocytosis, endocytosis, and ion transport, but how these processes are initiated and coordinated and the mechanotransduction pathways involved are not well understood. We observed that in response to a dynamic mechanical environment, increased apical membrane tension, but not pressure, stimulated apical membrane exocytosis and ion transport in bladder umbrella cells. The exocytic response was independent of temperature but required the cytoskeleton and the activity of a nonselective cation channel and the epithelial sodium channel.

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Bjerregaard, Henning F. "Side-specific Toxic Effects on the Membranes of Cultured Renal Epithelial Cells (A6)." Alternatives to Laboratory Animals 23, no. 4 (1995): 485–90. http://dx.doi.org/10.1177/026119299502300411.

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- A cultured epithelial cell line from toad kidney (A6) was used to investigate side-specific toxicity related to the apical (outer) and basolateral (inner) membranes of epithdia. Well-known inhibitors and stimulators of ion transport were used to show that the ion transport proteins are asymmetrically distributed: the apical membrane contains sodium and chloride channels and the basolateral membrane contains Na+/K+ pumps, Na+/Cl- co-transporters, potassium channels and receptors for antidiuretic hormone The data demonstrate that the cellular toxicity of chemicals decreases when they are added

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34

Diaz, Maira, Maria Jose Sanchez-Barrena, Juana Maria Gonzalez-Rubio, et al. "Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling." Proceedings of the National Academy of Sciences 113, no. 3 (2015): E396—E405. http://dx.doi.org/10.1073/pnas.1512779113.

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Regulation of ion transport in plants is essential for cell function. Abiotic stress unbalances cell ion homeostasis, and plants tend to readjust it, regulating membrane transporters and channels. The plant hormone abscisic acid (ABA) and the second messenger Ca2+ are central in such processes, as they are involved in the regulation of protein kinases and phosphatases that control ion transport activity in response to environmental stimuli. The identification and characterization of the molecular mechanisms underlying the effect of ABA and Ca2+ signaling pathways on membrane function are centr

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35

Lamprecht, G., U. Seidler, and M. Classen. "Intracellular pH-regulating ion transport mechanisms in parietal cell basolateral membrane vesicles." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 5 (1993): G903—G910. http://dx.doi.org/10.1152/ajpgi.1993.265.5.g903.

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Na(+)-H+ and Cl(-)-base exchangers on the parietal cell have been demonstrated by several authors. Controversy exists concerning a basolateral Na(+)-HCO3- cotransporter in the parietal cell. To clarify this issue, we prepared highly enriched basolateral membrane (BLM) and apical-tubulovesicular membrane (to serve as negative controls) vesicles from rabbit fundic mucosa. Na(+)-H+ exchange was demonstrated by measuring pH gradient-driven amiloride-sensitive 22Na+ uptake and Na+ gradient-driven proton uptake into voltage-clamped BLM but not into apical-tubulovesicular vesicles. Anion exchange was

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36

Middleton, J. P., A. W. Mangel, S. Basavappa, and J. G. Fitz. "Nucleotide receptors regulate membrane ion transport in renal epithelial cells." American Journal of Physiology-Renal Physiology 264, no. 5 (1993): F867—F873. http://dx.doi.org/10.1152/ajprenal.1993.264.5.f867.

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Regulation of plasma membrane ion transport by endogenous purinergic receptors was assessed in a distal renal (A6) cell line. Nucleotide analogues stimulated Na-K-Cl cotransport activity with relative potencies of ATP > UTP > ATP gamma S > 2-methylthio-ATP = alpha,beta-methylene ATP. Activation of nucleotide receptors with extracellular ATP and nucleotide analogues increased intracellular calcium concentration ([Ca2+]i) primarily by release of intracellular calcium stores, with relative potency of agonists similar to that seen for stimulation of Na-K-Cl cotransport. Neither the change

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37

Fernández de Labastida, Marc, and Andriy Yaroshchuk. "Nanofiltration of Multi-Ion Solutions: Quantitative Control of Concentration Polarization and Interpretation by Solution-Diffusion-Electro-Migration Model." Membranes 11, no. 4 (2021): 272. http://dx.doi.org/10.3390/membranes11040272.

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For effective use of advanced engineering models of nanofiltration quality of experimental input is crucial, especially in electrolyte mixtures where simultaneous rejections of various ions may be very different. In particular, this concerns the quantitative control of concentration polarization (CP). This work used a rotating disklike membrane test cell with equally accessible membrane surface, so the CP extent was the same over the membrane surface. This condition, which is not satisfied in the conventional membrane test cell, made possible correcting for CP easily even in multi-ion systems.

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Garvin, J. L., and K. R. Spring. "Regulation of apical membrane ion transport in Necturus gallbladder." American Journal of Physiology-Cell Physiology 263, no. 1 (1992): C187—C193. http://dx.doi.org/10.1152/ajpcell.1992.263.1.c187.

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Na and Cl movement through the apical membrane of Necturus gallbladder epithelium was investigated using electrophysiological and light microscopic measurements. Changes in membrane potential difference, fractional resistance of the apical membrane, and transepithelial resistance caused by changes in apical bath Cl concentration revealed the presence of a Cl conductance in the apical membrane of control tissues that was apparently not present in the preparations studied by other investigators. This Cl conductance was blocked by bumetanide (10(-5) M) or by the inhibitor of adenosine 3',5'-cycli

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Calahorra, Martha, Jorge Ramírez, S. Mónica Clemente, and Antonio Peña. "Electrochemical potential and ion transport in vesicles of yeast plasma membrane." Biochimica et Biophysica Acta (BBA) - Biomembranes 899, no. 2 (1987): 229–38. http://dx.doi.org/10.1016/0005-2736(87)90404-4.

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Chen, Tsung-Yu, and Tzyh-Chang Hwang. "CLC-0 and CFTR: Chloride Channels Evolved From Transporters." Physiological Reviews 88, no. 2 (2008): 351–87. http://dx.doi.org/10.1152/physrev.00058.2006.

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CLC-0 and cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channels play important roles in Cl− transport across cell membranes. These two proteins belong to, respectively, the CLC and ABC transport protein families whose members encompass both ion channels and transporters. Defective function of members in these two protein families causes various hereditary human diseases. Ion channels and transporters were traditionally viewed as distinct entities in membrane transport physiology, but recent discoveries have blurred the line between these two classes of membrane transport prot

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41

Stetson, D. L. "Turtle urinary bladder: regulation of ion transport by dynamic changes in plasma membrane area." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 257, no. 5 (1989): R973—R981. http://dx.doi.org/10.1152/ajpregu.1989.257.5.r973.

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Turtle urinary bladder possesses four ion transport processes: Na+ absorption, H+ secretion, and HCO3- secretion-Cl- absorption. Each transport process is performed by a specific epithelial cell type. Granular cells absorb Na+ but they are not sensitive to antidiuretic hormone (ADH), unlike toad bladder granular cells. alpha-Carbonic anhydrase-rich (CA) cells secrete H+ via an apical H+-adenosinetriphosphatase (ATPase). Under conditions of low CO2 tension, this active pump is contained in the limiting membranes of certain cytoplasmic vesicles. The vesicles fuse with the apical membrane, and H+

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Wang, Xuan, Peng An, Zhenglong Gu, Yongting Luo, and Junjie Luo. "Mitochondrial Metal Ion Transport in Cell Metabolism and Disease." International Journal of Molecular Sciences 22, no. 14 (2021): 7525. http://dx.doi.org/10.3390/ijms22147525.

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Mitochondria are vital to life and provide biological energy for other organelles and cell physiological processes. On the mitochondrial double layer membrane, there are a variety of channels and transporters to transport different metal ions, such as Ca2+, K+, Na+, Mg2+, Zn2+ and Fe2+/Fe3+. Emerging evidence in recent years has shown that the metal ion transport is essential for mitochondrial function and cellular metabolism, including oxidative phosphorylation (OXPHOS), ATP production, mitochondrial integrity, mitochondrial volume, enzyme activity, signal transduction, proliferation and apop

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Naranjo, David, Hans Moldenhauer, Matías Pincuntureo, and Ignacio Díaz-Franulic. "Pore size matters for potassium channel conductance." Journal of General Physiology 148, no. 4 (2016): 277–91. http://dx.doi.org/10.1085/jgp.201611625.

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Ion channels are membrane proteins that mediate efficient ion transport across the hydrophobic core of cell membranes, an unlikely process in their absence. K+ channels discriminate K+ over cations with similar radii with extraordinary selectivity and display a wide diversity of ion transport rates, covering differences of two orders of magnitude in unitary conductance. The pore domains of large- and small-conductance K+ channels share a general architectural design comprising a conserved narrow selectivity filter, which forms intimate interactions with permeant ions, flanked by two wider vest

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Briskin, Donald P. "Plasma membrane H+-transporting ATPase: Role in potassium ion transport?" Physiologia Plantarum 68, no. 1 (1986): 159–63. http://dx.doi.org/10.1111/j.1399-3054.1986.tb06612.x.

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Schwab, Albrecht, and Christian Stock. "Ion channels and transporters in tumour cell migration and invasion." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1638 (2014): 20130102. http://dx.doi.org/10.1098/rstb.2013.0102.

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Cell migration is a central component of the metastatic cascade requiring a concerted action of ion channels and transporters (migration-associated transportome), cytoskeletal elements and signalling cascades. Ion transport proteins and aquaporins contribute to tumour cell migration and invasion among other things by inducing local volume changes and/or by modulating Ca 2+ and H + signalling. Targeting cell migration therapeutically bears great clinical potential, because it is a prerequisite for metastasis. Ion transport proteins appear to be attractive candidate target proteins for this purp

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Hunter, M., J. D. Horisberger, B. Stanton, and G. Giebisch. "The collecting tubule of Amphiuma. I. Electrophysiological characterization." American Journal of Physiology-Renal Physiology 253, no. 6 (1987): F1263—F1272. http://dx.doi.org/10.1152/ajprenal.1987.253.6.f1263.

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Single collecting tubules of Amphiuma kidneys were perfused in vitro to characterize their electrophysiological properties. The lumen-negative potential (-24 mV) was abolished by amiloride in the lumen and by ouabain in the bath. Ion substitution experiments in the lumen demonstrated the presence of a large sodium conductance in the apical cell membrane, but no evidence was obtained for a significant potassium or chloride conductance. Ion substitutions in the bath solution and the depolarizing effect of barium on the basolateral membrane potential demonstrated the presence of a large potassium

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LANG, FLORIAN, GILLIAN L. BUSCH, MARKUS RITTER, et al. "Functional Significance of Cell Volume Regulatory Mechanisms." Physiological Reviews 78, no. 1 (1998): 247–306. http://dx.doi.org/10.1152/physrev.1998.78.1.247.

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Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory Mechanisms. Physiol. Rev. 78: 247–306, 1998. — To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specifically sensitive to dilution and concentration, determining the extent of macromolecular crowding. Even at constant extracellular osmolarity, volume constancy of any mammalian cell is permane

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Candia, O. A., L. R. Grillone, and T. C. Chu. "Forskolin effects on frog and rabbit corneal epithelium ion transport." American Journal of Physiology-Cell Physiology 251, no. 3 (1986): C448—C454. http://dx.doi.org/10.1152/ajpcell.1986.251.3.c448.

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The effects of forskolin on the electrophysiological parameters of the isolated corneal epithelium from bullfrog (Rana catesbeiana) were investigated. Forskolin stimulated the short-circuit current (SCC) and transepithelial potential difference (PDt), while reducing the transepithelial resistance. These effects were absent in Cl- -free bathing solutions. Furosemide, added either before or after forskolin, completely blocked the effects. Epinephrine and A23187, added after forskolin, produced only a small additional stimulation of the SCC. Propranolol neither blocked nor reduced the effect of f

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Forney, L. J. "Gas diffusion electrode-membrane cells: effects of ion transport." Industrial & Engineering Chemistry Research 32, no. 6 (1993): 1204–11. http://dx.doi.org/10.1021/ie00018a028.

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Zhou, Xianfeng, Punam Dalai, and Nita Sahai. "Semipermeable Mixed Phospholipid-Fatty Acid Membranes Exhibit K+/Na+ Selectivity in the Absence of Proteins." Life 10, no. 4 (2020): 39. http://dx.doi.org/10.3390/life10040039.

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Two important ions, K+ and Na+, are unequally distributed across the contemporary phospholipid-based cell membrane because modern cells evolved a series of sophisticated protein channels and pumps to maintain ion gradients. The earliest life-like entities or protocells did not possess either ion-tight membranes or ion pumps, which would result in the equilibration of the intra-protocellular K+/Na+ ratio with that in the external environment. Here, we show that the most primitive protocell membranes composed of fatty acids, that were initially leaky, would eventually become less ion permeable a

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