Log in

Relevant bibliographies by topics / Cell migration / Journal articles

To see the other types of publications on this topic, follow the link: Cell migration.

Journal articles on the topic 'Cell migration'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Cell migration.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Trepat, Xavier, Zaozao Chen, and Ken Jacobson. "Cell Migration." Comprehensive Physiology 2, no. 4 (2012): 2369–92. https://doi.org/10.1002/j.2040-4603.2012.tb00467.x.

Full text

Abstract:

AbstractCell migration is fundamental to establishing and maintaining the proper organization of multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell locomotion, from large‐scale migrations of epithelial sheets during gastrulation, to the movement of individual cells during development of the nervous system. In an adult organism, cell migration is essential for proper immune response, wound repair, and tissue homeostasis, while aberrant cell migration is found in various pathologies. Indeed, as our knowledge of migration increases, we can look forward to, for

APA, Harvard, Vancouver, ISO, and other styles

2

Thomas, L. A., and K. M. Yamada. "Contact stimulation of cell migration." Journal of Cell Science 103, no. 4 (1992): 1211–14. http://dx.doi.org/10.1242/jcs.103.4.1211.

Full text

Abstract:

Mass migrations of dense cell populations occur periodically during embryonic development. It is known that extracellular matrices, through which the cells migrate, facilitate locomotion. However, this does not explain how cells, such as neural crest, can migrate as a dense cohort of cells in essentially continuous contact with one another. We report here that unique behavioral characteristics of the migrating cells may contribute to cohesive migration. We used time-lapse video microscopy to analyze the migration of quail neural crest cells and of two crest derivatives, human melanoma cells an

APA, Harvard, Vancouver, ISO, and other styles

3

Deniz, Özdemir. "KAN0438757: A NOVEL PFKFB3 INHIBITOR THAT INDUCES PROGRAMMED CELL DEATH AND SUPPRESSES CELL MIGRATION IN NON-SMALL CELL LUNG CARCINOMA CELLS." Biotechnologia Acta 16, no. 5 (2023): 34–44. http://dx.doi.org/10.15407/biotech16.05.034.

Full text

Abstract:

Aim. PFKFB3 is glycolytic activators that is overexpressed in human lung cancer and plays a crucial role in multiple cellular functions including programmed cell death. Despite the many small molecules described as PFKFB3 inhibitors, some of them have shown disappointing results in vitro and in vivo. On the other hand KAN0438757, selective and potent, small molecule inhibitor has been developed. However, the effects of KAN0438757, in non-small cell lung carcinoma cells remain unknown. Herein, we sought to decipher the effect of KAN0438757 on proliferation, migration, DNA damage, and programmed

APA, Harvard, Vancouver, ISO, and other styles

4

Ffrench-Constant, C., and R. O. Hynes. "Patterns of fibronectin gene expression and splicing during cell migration in chicken embryos." Development 104, no. 3 (1988): 369–82. http://dx.doi.org/10.1242/dev.104.3.369.

Full text

Abstract:

A variety of evidence suggests that fibronectin (FN) promotes cell migration during embryogenesis, and it has been suggested that the deposition of FN along migratory pathways may also play a role in cell guidance. In order to investigate such a role for FN, it is important to determine the relative contribution of migrating and pathway-forming cells to the FN in the migratory track, as any synthesis of FN by the migrating cells might be expected to mask guidance cues provided by the exogenous FN from pathway-forming cells. We have therefore used in situ hybridization to determine in developin

APA, Harvard, Vancouver, ISO, and other styles

5

Deryugina, E. I., and M. A. Bourdon. "Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin." Journal of Cell Science 109, no. 3 (1996): 643–52. http://dx.doi.org/10.1242/jcs.109.3.643.

Full text

Abstract:

The role of tenascin in mediating tumor cell migration was studied using two cell migration models. In migration/invasion Transwell assays U251.3 glioma cells rapidly migrated through the 8 mu m pore size membranes onto tenascin- and fibronectin-coated surfaces. In this assay the number of cells migrating onto tenascin was 52.2 +/- 9.6% greater than on fibronectin within 4 hours. To assess cell migration rates and cell morphology, U251.3 migration was examined in a two-dimension spheroid outgrowth assay. The radial distance migrated by U251.3 cells from tumor spheroids was found to be 53.8 +/-

APA, Harvard, Vancouver, ISO, and other styles

6

Torrence, S. A. "Positional cues governing cell migration in leech neurogenesis." Development 111, no. 4 (1991): 993–1005. http://dx.doi.org/10.1242/dev.111.4.993.

Full text

Abstract:

The stereotyped distribution of identified neurons and glial cells in the leech nervous system is the product of stereotyped cell migrations and rearrangements during embryogenesis. To examine the dependence of long-distance cell migrations on positional cues provided by other tissues, embryos of Theromyzon rude were examined for the effects of selective ablation of various embryonic cell lines on the migration and final distribution of neural and glial precursor cells descended from the bilaterally paired ectodermal cell lines designated q bandlets. The results suggest that neither the commit

APA, Harvard, Vancouver, ISO, and other styles

7

Li, David, and Yu-li Wang. "Coordination of cell migration mediated by site-dependent cell–cell contact." Proceedings of the National Academy of Sciences 115, no. 42 (2018): 10678–83. http://dx.doi.org/10.1073/pnas.1807543115.

Full text

Abstract:

Contact inhibition of locomotion (CIL), the repulsive response of cells upon cell–cell contact, has been the predominant paradigm for contact-mediated responses. However, it is difficult for CIL alone to account for the complex behavior of cells within a multicellular environment, where cells often migrate in cohorts such as sheets, clusters, and streams. Although cell–cell adhesion and mechanical interactions play a role, how individual cells coordinate their migration within a multicellular environment remains unclear. Using micropatterned substrates to guide cell migration and manipulate ce

APA, Harvard, Vancouver, ISO, and other styles

8

Bradley, David. "Cell migration." Materials Today 14, no. 1-2 (2011): 10. http://dx.doi.org/10.1016/s1369-7021(11)70010-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Horwitz, Rick, and Donna Webb. "Cell migration." Current Biology 13, no. 19 (2003): R756—R759. http://dx.doi.org/10.1016/j.cub.2003.09.014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Wang, Heng, and Jiong Chen. "Cell migration: Collective cell migration is intrinsically stressful." Current Biology 34, no. 7 (2024): R275—R278. http://dx.doi.org/10.1016/j.cub.2024.02.061.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Harris, J., L. Honigberg, N. Robinson, and C. Kenyon. "Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position." Development 122, no. 10 (1996): 3117–31. http://dx.doi.org/10.1242/dev.122.10.3117.

Full text

Abstract:

In C. elegans, the Hox gene mab-5, which specifies the fates of cells in the posterior body region, has been shown to direct the migrations of certain cells within its domain of function. mab-5 expression switches on in the neuroblast QL as it migrates into the posterior body region. mab-5 activity is then required for the descendants of QL to migrate to posterior rather than anterior positions. What information activates Hox gene expression during this cell migration? How are these cells subsequently guided to their final positions? We address these questions by describing four genes, egl-20,

APA, Harvard, Vancouver, ISO, and other styles

12

Ridley, Anne J. "Rho GTPases and cell migration." Journal of Cell Science 114, no. 15 (2001): 2713–22. http://dx.doi.org/10.1242/jcs.114.15.2713.

Full text

Abstract:

Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration. Recent research has revealed new molecular links between Rho family proteins and the actin cytoskeleton, showing that they act to regulate actin polymerization, depolymerization and the activity of actin-associated myosins. In addition, studies on integrin signalling suggest that the substratum continuously feeds signals to Rho proteins in migrating cells to influence migration rate. There is al

APA, Harvard, Vancouver, ISO, and other styles

13

Legrand, Claire, Christine Gilles, Jean-Marie Zahm, et al. "Airway Epithelial Cell Migration Dynamics: MMP-9 Role in Cell–Extracellular Matrix Remodeling." Journal of Cell Biology 146, no. 2 (1999): 517–29. http://dx.doi.org/10.1083/jcb.146.2.517.

Full text

Abstract:

Cell spreading and migration associated with the expression of the 92-kD gelatinase (matrix metalloproteinase 9 or MMP-9) are important mechanisms involved in the repair of the respiratory epithelium. We investigated the location of MMP-9 and its potential role in migrating human bronchial epithelial cells (HBEC). In vivo and in vitro, MMP-9 accumulated in migrating HBEC located at the leading edge of a wound and MMP-9 expression paralleled cell migration speed. MMP-9 accumulated through an actin-dependent pathway in the advancing lamellipodia of migrating cells and was subsequently found acti

APA, Harvard, Vancouver, ISO, and other styles

14

Garcin, Clare, and Anne Straube. "Microtubules in cell migration." Essays in Biochemistry 63, no. 5 (2019): 509–20. http://dx.doi.org/10.1042/ebc20190016.

Full text

Abstract:

Abstract Directed cell migration is critical for embryogenesis and organ development, wound healing and the immune response. Microtubules are dynamic polymers that control directional migration through a number of coordinated processes: microtubules are the tracks for long-distance intracellular transport, crucial for delivery of new membrane components and signalling molecules to the leading edge of a migrating cell and the recycling of adhesion receptors. Microtubules act as force generators and compressive elements to support sustained cell protrusions. The assembly and disassembly of micro

APA, Harvard, Vancouver, ISO, and other styles

15

Zhao, Jieling, Youfang Cao, Luisa A. DiPietro, and Jie Liang. "Dynamic cellular finite-element method for modelling large-scale cell migration and proliferation under the control of mechanical and biochemical cues: a study of re-epithelialization." Journal of The Royal Society Interface 14, no. 129 (2017): 20160959. http://dx.doi.org/10.1098/rsif.2016.0959.

Full text

Abstract:

Computational modelling of cells can reveal insight into the mechanisms of the important processes of tissue development. However, current cell models have limitations and are challenged to model detailed changes in cellular shapes and physical mechanics when thousands of migrating and interacting cells need to be modelled. Here we describe a novel dynamic cellular finite-element model (DyCelFEM), which accounts for changes in cellular shapes and mechanics. It also models the full range of cell motion, from movements of individual cells to collective cell migrations. The transmission of mechan

APA, Harvard, Vancouver, ISO, and other styles

16

Shellard, Adam, and Roberto Mayor. "Supracellular migration – beyond collective cell migration." Journal of Cell Science 132, no. 8 (2019): jcs226142. http://dx.doi.org/10.1242/jcs.226142.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Murakami, Shinya, Yo Otsuka, Manabu Sugimoto, and Toshiyuki Mitsui. "3H1010 Controlled cell migration with ultrasound(Cell Biology III:Cytoskeleton & Motility,Oral Presentation)." Seibutsu Butsuri 52, supplement (2012): S70. http://dx.doi.org/10.2142/biophys.52.s70_4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Boehm, Manfred, and Elizabeth G. Nabel. "Cell Cycle and Cell Migration." Circulation 103, no. 24 (2001): 2879–81. http://dx.doi.org/10.1161/01.cir.103.24.2879.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

McLane, Louis T., Anthony Kramer, Carrie Harris, Edward Park, Hang Lu, and Jennifer E. Curtis. "Cell Coat Mediated Cell Migration." Biophysical Journal 96, no. 3 (2009): 629a. http://dx.doi.org/10.1016/j.bpj.2008.12.3325.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Chen, Zaozao, Qiwei Li, Shihui Xu, Jun Ouyang, and Hongmei Wei. "Nanotopography-Modulated Epithelial Cell Collective Migration." Journal of Biomedical Nanotechnology 17, no. 6 (2021): 1079–87. http://dx.doi.org/10.1166/jbn.2021.3086.

Full text

Abstract:

Matrix nanotopography plays an essential role in regulating cell behaviors including cell proliferation, differentiation, and migration. While studies on isolated single cell migration along the nanostructural orientation have been reported for various cell types, there remains a lack of understanding of how nanotopography regulates the behavior of collectively migrating cells during processes such as epithelial wound healing. We demonstrated that collective migration of epithelial cells was promoted on nanogratings perpendicular to, but not on those parallel to, the wound-healing axis. We fur

APA, Harvard, Vancouver, ISO, and other styles

21

Augustin-Voss, H. G., and B. U. Pauli. "Migrating endothelial cells are distinctly hyperglycosylated and express specific migration-associated cell surface glycoproteins." Journal of Cell Biology 119, no. 2 (1992): 483–91. http://dx.doi.org/10.1083/jcb.119.2.483.

Full text

Abstract:

Migration of endothelial cells is one of the first cellular responses in the cascade of events that leads to re-endothelialization of an injured vessel and neovascularization of growing tissues and tumors. To examine the hypothesis that endothelial cells express a specific migration-associated phenotype, we analyzed the cell surface glycoprotein expression of migrating bovine aortic endothelial cell (BAECs). Light microscopic analysis revealed an upregulation of binding sites for the lectins Concanavalin A (Con A), wheat germ agglutinin (WGA), and peanut agglutinin after neuraminidase treatmen

APA, Harvard, Vancouver, ISO, and other styles

22

Kim, Jin Man, Minji Lee, Nury Kim, and Won Do Heo. "Optogenetic toolkit reveals the role of Ca2+sparklets in coordinated cell migration." Proceedings of the National Academy of Sciences 113, no. 21 (2016): 5952–57. http://dx.doi.org/10.1073/pnas.1518412113.

Full text

Abstract:

Cell migration is controlled by various Ca2+signals. Local Ca2+signals, in particular, have been identified as versatile modulators of cell migration because of their spatiotemporal diversity. However, little is known about how local Ca2+signals coordinate between the front and rear regions in directionally migrating cells. Here, we elucidate the spatial role of local Ca2+signals in directed cell migration through combinatorial application of an optogenetic toolkit. An optically guided cell migration approach revealed the existence of Ca2+sparklets mediated by L-type voltage-dependent Ca2+chan

APA, Harvard, Vancouver, ISO, and other styles

23

Rørth, Pernille. "Collective Cell Migration." Annual Review of Cell and Developmental Biology 25, no. 1 (2009): 407–29. http://dx.doi.org/10.1146/annurev.cellbio.042308.113231.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Cumberbatch, M., R. J. Dearman, C. E. M. Griffiths, and I. Kimber. "Langerhans cell migration." Clinical and Experimental Dermatology 25, no. 5 (2000): 413–18. http://dx.doi.org/10.1046/j.1365-2230.2000.00678.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Spector, Mario, Leandro Peretti, Favio Vincitorio, and Luciano Iglesias. "Bacterial Migration Cell." Procedia Materials Science 8 (2015): 346–50. http://dx.doi.org/10.1016/j.mspro.2015.04.083.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Sutherland, Stephani. "Targeting cell migration." Drug Discovery Today 8, no. 1 (2003): 6–7. http://dx.doi.org/10.1016/s1359-6446(02)02549-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Golden, J. A., J. C. Zitz, K. McFadden, and C. L. Cepko. "Cell migration in the developing chick diencephalon." Development 124, no. 18 (1997): 3525–33. http://dx.doi.org/10.1242/dev.124.18.3525.

Full text

Abstract:

We previously reported that retrovirally marked clones in the mature chick diencephalon were widely dispersed in the mediolateral, dorsoventral and rostrocaudal planes. The current study was undertaken to define the migration routes that led to the dispersion. Embryos were infected between stages 10 and 14 with a retroviral stock encoding alkaline phosphatase and a library of molecular tags. Embryos were harvested 2.5-5.5 days later and the brains were fixed and serially sectioned. Sibling relationships were determined following PCR amplification and sequencing of the molecular tag. On embryon

APA, Harvard, Vancouver, ISO, and other styles

28

Nishita, Michiru, Chinatsu Tomizawa, Masahiro Yamamoto, Yuji Horita, Kazumasa Ohashi, and Kensaku Mizuno. "Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration." Journal of Cell Biology 171, no. 2 (2005): 349–59. http://dx.doi.org/10.1083/jcb.200504029.

Full text

Abstract:

Cofilin mediates lamellipodium extension and polarized cell migration by accelerating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by LIM kinase (LIMK)–1-mediated phosphorylation and is reactivated by cofilin phosphatase Slingshot (SSH)-1L. In this study, we show that cofilin activity is temporally and spatially regulated by LIMK1 and SSH1L in chemokine-stimulated Jurkat T cells. The knockdown of LIMK1 suppressed chemokine-induced lamellipodium formation and cell migration, whereas SSH1L knockdown produced and retained multiple lamellipodial protrusion

APA, Harvard, Vancouver, ISO, and other styles

29

Petrie, Ryan J., Núria Gavara, Richard S. Chadwick, and Kenneth M. Yamada. "Nonpolarized signaling reveals two distinct modes of 3D cell migration." Journal of Cell Biology 197, no. 3 (2012): 439–55. http://dx.doi.org/10.1083/jcb.201201124.

Full text

Abstract:

We search in this paper for context-specific modes of three-dimensional (3D) cell migration using imaging for phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and active Rac1 and Cdc42 in primary fibroblasts migrating within different 3D environments. In 3D collagen, PIP3 and active Rac1 and Cdc42 were targeted to the leading edge, consistent with lamellipodia-based migration. In contrast, elongated cells migrating inside dermal explants and the cell-derived matrix (CDM) formed blunt, cylindrical protrusions, termed lobopodia, and Rac1, Cdc42, and PIP3 signaling was nonpolarized. Reducing Rho

APA, Harvard, Vancouver, ISO, and other styles

30

Bachmann, Alice, and Anne Straube. "Kinesins in cell migration." Biochemical Society Transactions 43, no. 1 (2015): 79–83. http://dx.doi.org/10.1042/bst20140280.

Full text

Abstract:

Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly of the microtubule polymer. In migrating cells, microtubules control the asymmetry between the front and rear of the cell by differentially regulating force generation processes and substrate adhesion. Many of these functions are mediated by kinesins, transporters as well as track modulators. In this review, we summarize the current knowledge

APA, Harvard, Vancouver, ISO, and other styles

31

Hammad, Ayat S., and Khaled Machaca. "Store Operated Calcium Entry in Cell Migration and Cancer Metastasis." Cells 10, no. 5 (2021): 1246. http://dx.doi.org/10.3390/cells10051246.

Full text

Abstract:

Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements. This polarization is reflected in various Ca2+ signaling pathways that impinge on cell movement. In particular, store-operated Ca2+ entry (SOCE) plays important roles in regulating cell movement at both the front and rear of migrating cells. SOCE represents a predominant Ca2+ influx pathway in non-excitable cells, which are the primary migrating cells in multicellular organisms. In this revi

APA, Harvard, Vancouver, ISO, and other styles

32

Schwab, Albrecht. "Function and spatial distribution of ion channels and transporters in cell migration." American Journal of Physiology-Renal Physiology 280, no. 5 (2001): F739—F747. http://dx.doi.org/10.1152/ajprenal.2001.280.5.f739.

Full text

Abstract:

Cell migration plays a central role in many physiological and pathophysiological processes, such as embryogenesis, immune defense, wound healing, or the formation of tumor metastases. Detailed models have been developed that describe cytoskeletal mechanisms of cell migration. However, evidence is emerging that ion channels and transporters also play an important role in cell migration. The purpose of this review is to examine the function and subcellular distribution of ion channels and transporters in cell migration. Topics covered will be a brief overview of cytoskeletal mechanisms of migrat

APA, Harvard, Vancouver, ISO, and other styles

33

Maeda, Nobuaki, та Masaharu Noda. "Involvement of Receptor-like Protein Tyrosine Phosphatase ζ/RPTPβ and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration". Journal of Cell Biology 142, № 1 (1998): 203–16. http://dx.doi.org/10.1083/jcb.142.1.203.

Full text

Abstract:

Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase ζ (PTPζ)/receptor-like protein tyrosine phosphatase β (RPTPβ) expressed in the brain as a chondroitin sulfate proteoglycan. Pleiotrophin and PTPζ isoforms are localized along the radial glial fibers, a scaffold for neuronal migration, suggesting that these molecules are involved in migratory processes of neurons during brain development. In this study, we examined the roles of pleiotrophin-PTPζ interaction in the neuronal migration using cell migration assay systems with glass

APA, Harvard, Vancouver, ISO, and other styles

34

Canver, Adam C., and Alisa Morss Clyne. "Quantification of Multicellular Organization, Junction Integrity, and Substrate Features in Collective Cell Migration." Microscopy and Microanalysis 23, no. 1 (2017): 22–33. http://dx.doi.org/10.1017/s1431927617000071.

Full text

Abstract:

AbstractQuantitative analysis of multicellular organization, cell–cell junction integrity, and substrate properties is essential to understand the mechanisms underlying collective cell migration. However, spatially and temporally defining these properties is difficult within collectively migrating cell groups due to challenges in accurate cell segmentation within the monolayer. In this paper, we present Matlab®-based algorithms to spatially quantify multicellular organization (migration distance, interface roughness, and cell alignment, area, and morphology), cell–cell junction integrity, and

APA, Harvard, Vancouver, ISO, and other styles

35

Bradley, Pamela L., and Deborah J. Andrew. "ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster." Development 128, no. 15 (2001): 3001–15. http://dx.doi.org/10.1242/dev.128.15.3001.

Full text

Abstract:

During development, directed cell migration is crucial for achieving proper shape and function of organs. One well-studied example is the embryonic development of the larval tracheal system of Drosophila, in which at least four signaling pathways coordinate cell migration to form an elaborate branched network essential for oxygen delivery throughout the larva. FGF signaling is required for guided migration of all tracheal branches, whereas the DPP, EGF receptor, and Wingless/WNT signaling pathways each mediate the formation of specific subsets of branches. Here, we characterize ribbon, which e

APA, Harvard, Vancouver, ISO, and other styles

36

Zhu, Zhiwen, Yongping Chai, Huifang Hu, et al. "Spatial confinement of receptor activity by tyrosine phosphatase during directional cell migration." Proceedings of the National Academy of Sciences 117, no. 25 (2020): 14270–79. http://dx.doi.org/10.1073/pnas.2003019117.

Full text

Abstract:

Directional cell migration involves signaling cascades that stimulate actin assembly at the leading edge, and additional pathways must inhibit actin polymerization at the rear. During neuroblast migration inCaenorhabditis elegans, the transmembrane protein MIG-13/Lrp12 acts through the Arp2/3 nucleation-promoting factors WAVE and WASP to guide the anterior migration. Here we show that a tyrosine kinase, SRC-1, directly phosphorylates MIG-13 and promotes its activity on actin assembly at the leading edge. In GFP knockin animals, SRC-1 and MIG-13 distribute along the entire plasma membrane of mi

APA, Harvard, Vancouver, ISO, and other styles

37

Ozcelikkale, Altug, J. Craig Dutton, Frederick Grinnell, and Bumsoo Han. "Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices." Journal of The Royal Society Interface 14, no. 135 (2017): 20170287. http://dx.doi.org/10.1098/rsif.2017.0287.

Full text

Abstract:

Fibroblast migration plays a key role during various physiological and pathological processes. Although migration of individual fibroblasts has been well studied, migration in vivo often involves simultaneous locomotion of fibroblasts sited in close proximity, so-called ‘ en masse migration’, during which intensive cell–cell interactions occur. This study aims to understand the effects of matrix mechanical environments on the cell–matrix and cell–cell interactions during en masse migration of fibroblasts on collagen matrices. Specifically, we hypothesized that a group of migrating cells can si

APA, Harvard, Vancouver, ISO, and other styles

38

Andalur Nandagopal, Saravanan, Deepak Upreti, Susy Santos, et al. "Dual roles of GM-CSF in modulating NK-cell migratory properties (CAM4P.147)." Journal of Immunology 194, no. 1_Supplement (2015): 185.5. http://dx.doi.org/10.4049/jimmunol.194.supp.185.5.

Full text

Abstract:

Abstract Background: Natural Killer (NK) cells play a key role in innate immunity against viral, microbial infections and transformed cells and their migration for effector function to peripheral tissues or inflamed lymph nodes are tightly regulated. Of interest, production of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) by cancer cells is correlated to host immune suppression and tumor metastasis, suggesting an immune evasion property of GM-CSF. Here we examined role(s) of recombinant GM-CSF in the regulation of NK-cell migratory properties in vitro. Methods: Previously published

APA, Harvard, Vancouver, ISO, and other styles

39

Brückner, David B., Alexandra Fink, Joachim O. Rädler, and Chase P. Broedersz. "Disentangling the behavioural variability of confined cell migration." Journal of The Royal Society Interface 17, no. 163 (2020): 20190689. http://dx.doi.org/10.1098/rsif.2019.0689.

Full text

Abstract:

Cell-to-cell variability is inherent to numerous biological processes, including cell migration. Quantifying and characterizing the variability of migrating cells is challenging, as it requires monitoring many cells for long time windows under identical conditions. Here, we observe the migration of single human breast cancer cells (MDA-MB-231) in confining two-state micropatterns. To describe the stochastic dynamics of this confined migration, we employ a dynamical systems approach. We identify statistics to measure the behavioural variance of the migration, which significantly exceeds that pr

APA, Harvard, Vancouver, ISO, and other styles

40

Venkatachalam, Thejasvi, Sushma Mannimala, Yeshaswi Pulijala, and Martha C. Soto. "CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases." PLOS Genetics 20, no. 7 (2024): e1011330. http://dx.doi.org/10.1371/journal.pgen.1011330.

Full text

Abstract:

Coordinated activation and inhibition of F-actin supports the movements of morphogenesis. Understanding the proteins that regulate F-actin is important, since these proteins are mis-regulated in diseases like cancer. Our studies of C. elegans embryonic epidermal morphogenesis identified the GTPase CED-10/Rac1 as an essential activator of F-actin. However, we need to identify the GEF, or Guanine-nucleotide Exchange Factor, that activates CED-10/Rac1 during embryonic cell migrations. The two-component GEF, CED-5/CED-12, is known to activate CED-10/Rac1 to promote cell movements that result in th

APA, Harvard, Vancouver, ISO, and other styles

41

Hathaway, HJ, and BD Shur. "Cell surface beta 1,4-galactosyltransferase functions during neural crest cell migration and neurulation in vivo." Journal of Cell Biology 117, no. 2 (1992): 369–82. http://dx.doi.org/10.1083/jcb.117.2.369.

Full text

Abstract:

Mesenchymal cell migration and neurite outgrowth are mediated in part by binding of cell surface beta 1,4-galactosyltransferase (GalTase) to N-linked oligosaccharides within the E8 domain of laminin. In this study, we determined whether cell surface GalTase functions during neural crest cell migration and neural development in vivo using antibodies raised against affinity-purified chicken serum GalTase. The antibodies specifically recognized two embryonic proteins of 77 and 67 kD, both of which express GalTase activity. The antibodies also immunoprecipitated and inhibited chick embryo GalTase

APA, Harvard, Vancouver, ISO, and other styles

42

Goldfinger, Lawrence E., Jaewon Han, William B. Kiosses, Alan K. Howe та Mark H. Ginsberg. "Spatial restriction of α4 integrin phosphorylation regulates lamellipodial stability and α4β1-dependent cell migration". Journal of Cell Biology 162, № 4 (2003): 731–41. http://dx.doi.org/10.1083/jcb.200304031.

Full text

Abstract:

Întegrins coordinate spatial signaling events essential for cell polarity and directed migration. Such signals from α4 integrins regulate cell migration in development and in leukocyte trafficking. Here, we report that efficient α4-mediated migration requires spatial control of α4 phosphorylation by protein kinase A, and hence localized inhibition of binding of the signaling adaptor, paxillin, to the integrin. In migrating cells, phosphorylated α4 accumulated along the leading edge. Blocking α4 phosphorylation by mutagenesis or by inhibition of protein kinase A drastically reduced α4-dependen

APA, Harvard, Vancouver, ISO, and other styles

43

Runyan, R. B., G. D. Maxwell, and B. D. Shur. "Evidence for a novel enzymatic mechanism of neural crest cell migration on extracellular glycoconjugate matrices." Journal of Cell Biology 102, no. 2 (1986): 432–41. http://dx.doi.org/10.1083/jcb.102.2.432.

Full text

Abstract:

Migrating embryonic cells have high levels of cell surface galactosyltransferase (GalTase) activity. It has been proposed that GalTase participates during migration by recognizing and binding to terminal N-acetylglucosamine (GlcNAc) residues on glycoconjugates within the extracellular matrix (Shur, B. D., 1982, Dev. Biol. 91:149-162). We tested this hypothesis using migrating neural crest cells as an in vitro model system. Cell surface GalTase activity was perturbed using three independent sets of reagents, and the effects on cell migration were analyzed by time-lapse microphotography. The Gal

APA, Harvard, Vancouver, ISO, and other styles

44

Montell, D. J. "The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development." Development 126, no. 14 (1999): 3035–46. http://dx.doi.org/10.1242/dev.126.14.3035.

Full text

Abstract:

Cell migrations are found throughout the animal kingdom and are among the most dramatic and complex of cellular behaviors. Historically, the mechanics of cell migration have been studied primarily in vitro, where cells can be readily viewed and manipulated. However, genetic approaches in relatively simple model organisms are yielding additional insights into the molecular mechanisms underlying cell movements and their regulation during development. This review will focus on these simple model systems where we understand some of the signaling and receptor molecules that stimulate and guide cell

APA, Harvard, Vancouver, ISO, and other styles

45

Isozaki, Yusuke, Kouki Sakai, Kenta Kohiro, et al. "The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks." Molecular Biology of the Cell 31, no. 8 (2020): 741–52. http://dx.doi.org/10.1091/mbc.e19-07-0357.

Full text

Abstract:

Collective cell migration is crucial for tissue remodeling and cancer invasion. A RhoA-targeting guanine nucleotide exchange factor, Solo, localizes to the cell–cell contact sites in collectively migrating cells and acts as a brake for collective cell migration via promoting the RhoA-ROCK pathway and regulating the keratin-8/keratin-18 networks.

APA, Harvard, Vancouver, ISO, and other styles

46

Law, Ah-Lai, Anne Vehlow, Maria Kotini, et al. "Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo." Journal of Cell Biology 203, no. 4 (2013): 673–89. http://dx.doi.org/10.1083/jcb.201304051.

Full text

Abstract:

Cell migration is essential for development, but its deregulation causes metastasis. The Scar/WAVE complex is absolutely required for lamellipodia and is a key effector in cell migration, but its regulation in vivo is enigmatic. Lamellipodin (Lpd) controls lamellipodium formation through an unknown mechanism. Here, we report that Lpd directly binds active Rac, which regulates a direct interaction between Lpd and the Scar/WAVE complex via Abi. Consequently, Lpd controls lamellipodium size, cell migration speed, and persistence via Scar/WAVE in vitro. Moreover, Lpd knockout mice display defectiv

APA, Harvard, Vancouver, ISO, and other styles

47

Rappel, Wouter-Jan. "Cell–cell communication during collective migration." Proceedings of the National Academy of Sciences 113, no. 6 (2016): 1471–73. http://dx.doi.org/10.1073/pnas.1524893113.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Mishra, Abhinava K., Joseph P. Campanale, James A. Mondo, and Denise J. Montell. "Cell interactions in collective cell migration." Development 146, no. 23 (2019): dev172056. http://dx.doi.org/10.1242/dev.172056.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Conway, James R. W., and Guillaume Jacquemet. "Cell matrix adhesion in cell migration." Essays in Biochemistry 63, no. 5 (2019): 535–51. http://dx.doi.org/10.1042/ebc20190012.

Full text

Abstract:

Abstract The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing an

APA, Harvard, Vancouver, ISO, and other styles

50

Kino-oka, Masahiro, Yasunori Takezawa, Ngo Xuan Trung, and Masahito Taya. "Cell migration in multilayer cell sheet." Journal of Bioscience and Bioengineering 108 (November 2009): S36. http://dx.doi.org/10.1016/j.jbiosc.2009.08.085.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!