Academic literature on the topic 'Cell-penetrating peptides (CPPs)'

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Journal articles on the topic "Cell-penetrating peptides (CPPs)"

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Eggimann, Gabriela A., Emilyne Blattes, Stefanie Buschor, et al. "Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells." Chem. Commun. 50, no. 55 (2014): 7254–57. http://dx.doi.org/10.1039/c4cc02780a.

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Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs.
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Kerkis, Alexandre, Mirian A. F. Hayashi, Tetsuo Yamane, and Irina Kerkis. "Properties of cell penetrating peptides (CPPs)." IUBMB Life 58, no. 1 (2006): 7–13. http://dx.doi.org/10.1080/15216540500494508.

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Shamova, O. V., A. S. Nazarov, P. M. Kopeykin, et al. "BACTENECINS AS CELL-PENETRATING PEPTIDES." Medical academic journal 19, no. 1S (2019): 178–79. http://dx.doi.org/10.17816/maj191s1178-179.

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Cell-Penetrating Peptides (CPPs) are molecules that can easily internalize into eukaryotic cells, as well as deliver across their membranes a variety of compounds (proteins, nucleic acids, liposomes, nanoparticles, etc.). CPPs are considered as promising components of anticancer drugs, serving for delivery of active ingredients into malignant cells, therefore, a detailed study of a mechanism of action of CPPs and search for novel, more effective peptides are vital tasks of current biological and medical research. An ability of proline-rich peptides bactenecins (ChBac5, ChBac3.4, mini-ChBac7.5N
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Morán-Torres, Rafael, David A. Castillo González, Maria Luisa Durán-Pastén, Beatriz Aguilar-Maldonado, Susana Castro-Obregón, and Gabriel Del Rio. "Selective Moonlighting Cell-Penetrating Peptides." Pharmaceutics 13, no. 8 (2021): 1119. http://dx.doi.org/10.3390/pharmaceutics13081119.

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Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable molecules into cells, such as drugs and DNA probes, among others. However, the internalization of these peptides lacks specificity: CPPs internalize indistinctly on different cell types. Two major approaches have been described to address this problem: (i) targeting, in which a receptor-recognizing sequence is added to a CPP, and (ii) activation, where a non-active form of the CPP is activated once it interacts with cell target components. These str
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Ruseska, Ivana, and Andreas Zimmer. "Internalization mechanisms of cell-penetrating peptides." Beilstein Journal of Nanotechnology 11 (January 9, 2020): 101–23. http://dx.doi.org/10.3762/bjnano.11.10.

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In today’s modern era of medicine, macromolecular compounds such as proteins, peptides and nucleic acids are dethroning small molecules as leading therapeutics. Given their immense potential, they are highly sought after. However, their application is limited mostly due to their poor in vivo stability, limited cellular uptake and insufficient target specificity. Cell-penetrating peptides (CPPs) represent a major breakthrough for the transport of macromolecules. They have been shown to successfully deliver proteins, peptides, siRNAs and pDNA in different cell types. In general, CPPs are basic p
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Adhikari, Sayanee, Turki I. Alahmadi, Zifan Gong, and Amy J. Karlsson. "Expression of Cell-Penetrating Peptides Fused to Protein Cargo." Journal of Molecular Microbiology and Biotechnology 28, no. 4 (2018): 159–68. http://dx.doi.org/10.1159/000494084.

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Cell-penetrating peptides (CPPs) are short peptides that can cross cell membranes. CPPs enable the delivery of biomolecules into cells and can act as drug-delivery vectors. Because recombinant production of CPPs as fusions to protein “cargo” leads to low yields for some CPP-cargo fusions, approaches to enhance the recombinant expression of peptide-cargo fusions need to be identified. We optimized expression conditions in <i>Escherichia coli</i> for fusions of CPPs (SynB, histatin-5, and MPG) to the cargo proteins biotin carboxyl carrier protein, maltose-binding protein, and green f
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Henriques, Sónia Troeira, Manuel Nuno Melo, and Miguel A. R. B. Castanho. "Cell-penetrating peptides and antimicrobial peptides: how different are they?" Biochemical Journal 399, no. 1 (2006): 1–7. http://dx.doi.org/10.1042/bj20061100.

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Some cationic peptides, referred to as CPPs (cell-penetrating peptides), have the ability to translocate across biological membranes in a non-disruptive way and to overcome the impermeable nature of the cell membrane. They have been successfully used for drug delivery into mammalian cells; however, there is no consensus about the mechanism of cellular uptake. Both endocytic and non-endocytic pathways are supported by experimental evidence. The observation that some AMPs (antimicrobial peptides) can enter host cells without damaging their cytoplasmic membrane, as well as kill pathogenic agents,
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Brugnano, Jamie, Brian C. Ward, and Alyssa Panitch. "Cell penetrating peptides can exert biological activity: a review." BioMolecular Concepts 1, no. 2 (2010): 109–16. http://dx.doi.org/10.1515/bmc.2010.016.

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AbstractCell penetrating peptides (CPPs) have been successful in delivering cargo into many different cell types and are an important alternative to other methods of permeation that might damage the integrity of the cell membrane. The traditional view of CPPs is that they are inert molecules that can be successfully used to deliver many cargos intracellularly. The goal of this review is to challenge this traditional understanding of CPPs. Recent literature has demonstrated that CPPs themselves can convey biological activity, including the alteration of gene expression and inhibition of protein
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Chen, L., and S. D. Harrison. "Cell-penetrating peptides in drug development: enabling intracellular targets." Biochemical Society Transactions 35, no. 4 (2007): 821–25. http://dx.doi.org/10.1042/bst0350821.

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A large body of literature has shown that CPPs (cell-penetrating peptides) are capable of carrying macromolecules across the plasma membrane. CPPs can penetrate a wide variety of tissue types and enable modulation of intracellular targets with molecules that, by themselves, are incapable of penetrating cells. As a result, CPPs are recognized for their potential value in validating intracellular targets that could lead to drug discovery programmes [Dietz and Bahr (2004) Mol. Cell Neurosci. 27, 85–131]. The potential for CPP–drug conjugates to be used as human therapeutic agents has not been ext
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Taylor, Rebecca E., and Maliha Zahid. "Cell Penetrating Peptides, Novel Vectors for Gene Therapy." Pharmaceutics 12, no. 3 (2020): 225. http://dx.doi.org/10.3390/pharmaceutics12030225.

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Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first identified ~25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring peptides, able to carry variety of cargoes across the cellular membranes in an intact, functional form. Since their initial description and characterization, the field of cell penetrating peptides as vectors has exploded. The cargoes they can deliver range from other small peptides, full-length proteins, nucleic acids including RNA and DNA, liposomes, nanoparticles, and viral particles as well as radioisotopes an
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Dissertations / Theses on the topic "Cell-penetrating peptides (CPPs)"

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Amoura, Mehdi. "Conception et étude de nouveaux peptides vecteurs cycliques." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066635/document.

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Les peptides vecteurs ou CPP sont de petits peptides, en général de taille inférieure à 30 acides aminés. Parmi les nombreux CPP décrits dans la littérature, les peptides riches en arginine ont fait l'objet d'une attention particulière. Plusieurs modifications chimiques du squelette peptidique conduisant à une distribution spatiale différente des groupes fonctionnels, ou encore l'introduction de chaînes aliphatiques ont été effectuées pour accroitre la capacité du peptide à traverser la membrane de la cellule. L'objectif de ce travail a été le développement de nouveaux peptides vecteurs cycliq
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Von, Zuben Eliete de Souza. "Lipossomas funcionalizados com peptídeos de transdução de membrana para administração intranasal de insulina no tratamento do diabetes mellitus /." Araraquara, 2019. http://hdl.handle.net/11449/183625.

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Orientador: Marlus Chorilli<br>Resumo: O diabetes mellitus (DM) é uma síndrome metabólica caracterizada por deficiência na produção/secreção pancreática de insulina e/ou resistência à ação do hormônio nos tecidos alvo, resultando em hiperglicemia. Diversas pesquisas têm desencadeado o desenvolvimento de novos sistemas de administração de insulina que possibilitem a utilização de vias alternativas à parenteral, com destaque à administração de insulina por via nasal. Esta via tem-se mostrado promissora, pois pode promover uma rápida absorção do fármaco e aumentar a sua biodisponibilidade. Entret
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Eiríksdóttir, Emelía. "Structures, toxicity and internalization of cell-penetrating peptides." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38607.

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Cellular internalization is a highly regulated process controlled by proteins in the plasma membrane. Large and hydrophilic compounds, in particular, face difficulties conquering the plasma membrane barrier in order to gain access to intracellular environment. This puts serious constrains on the drug industry since many drugs are hydrophilic. Several methods aiming at aiding the cellular internalization of otherwise impermeable compounds have therefore been developed. One such class, so-called cell-penetrating peptides (CPPs), emerged around twenty years ago. This group constitutes hundreds of
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Gomez, Jose A. "Development of Cell Penetrating Bax Inhibiting Peptides (BIP)." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1252025677.

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EL, Andaloussi Samir. "Vectorization of oligonucleotides with cell-penetrating peptides : Characterization of uptake mechanisms and cytotoxicity." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7167.

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The hydrophobic plasma membrane constitutes an indispensable barrier for cells in living animals. Albeit being pivotal for the maintenance of cells, the inability to cross the plasma membrane is still one of the major obstacles to overcome in order to progress current drug development. A group of substances, with restricted access to the interior of cells, which has shown great promise for future clinical use is oligonucleotides that are exploited to interfere with gene expression. Short interfering RNAs that are utilized to confer gene silencing and splice correcting oligonucleotides, applied
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Müller, Judith. "Detailed comparison of CPP's uptake properties for pro-apoptotic cargo delivery." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16589.

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Limitierend für pharmakologische Therapien ist oft die Unfähigkeit des Wirkstoffes, biologische Membranen zu überwinden, weswegen häufig Transportmoleküle wie z.B. zellpenetrierende Peptide (CPPs, cell penetrating peptides) benutzt werden. Von den über 100 beschriebenen CPPs wurde bisher nur eine kleine Anzahl systematisch verglichen, was die Auswahl des „richtigen“ CPPs für eine Anwendung erschwert. Ziel dieser vorliegenden Arbeit war es, das pro-apoptotische Peptid KLA mittels CPPs spezifisch in Krebszellen zu transportieren. Untersucht wurden: (I) Verschiedene CPPs in unterschiedlichen Ze
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Rosés, Subirós Cristina. "Solid-phase synthesis of cell-penetrating γ-peptide/antimicrobial peptide conjugates and of cyclic lipodepsipeptides derived from fengycins". Doctoral thesis, Universitat de Girona, 2016. http://hdl.handle.net/10803/393895.

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This thesis is focused on the development of synthetic approaches to obtain new bioactive peptides. The first part deals with the design of new antimicrobial peptide/cell-penetrating peptide conjugates as anticancer agents. Their conjugation enhanced the activity of the antimicrobial peptides against cancer cells while maintained their low toxicity. These compounds are interesting for the design of new anticancer agents. On the second part, a new versatile methodology for the synthesis of natural fengycin derivatives is described. Our strategy represents the first synthetic approach for the to
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Eriksson, Jonas. "Gene therapy tools: oligonucleotides and peptides." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-132271.

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Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. One of the many gene therapies developed so far is RNA-cleaving deoxyribozymes, short DNA oligonucleotides that specifically bind to and cleave RNA. Since the development of these synthetic catalytic oligonucleotides, the main way of determining their cleavage kinetics has been through the use of a laborious and error prone gel assay to quantify substrate and product at different time-points. We have developed two new methods for this purpose. The first on
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Tisseyre, Céline. "La maurocalcine : substance naturelle d'intérêt thérapeutique." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV047/document.

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La maurocalcine (MCa) est une toxine de 33 acides aminés initialement issue du venin du scorpionScorpio maurus palmatus, et est considérée comme faisant partie de la famille des CPP(Cell Penetrating Peptides) depuis de nombreuses années déjà. La MCa présente donc un intérêtthérapeutique certain dans le domaine de la délivrance intracellulaire de cargos, et lestravaux exposés ici cherchent à caractériser au mieux les propriétés de pénétration de la moléculenative ainsi que celle de certains de ses variants.Après avoir quantifié l’internalisation de plusieurs variants tronqués (linéaires), j’ai
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Richter, Susan. "Neue zellpenetrierende Phosphopeptide für die molekulare Bildgebung." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-68594.

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Im Kontext komplexer zellulärer Prozesse stellen Phosphopeptide essentielle bioaktive Verbindungen dar, die mit Phosphorylierungs- und Dephosphorylierungsreaktionen eng verbunden sind. Diese Prozesse sind in die Regulation nahezu jeder zellulären Funktion involviert und spielen damit ebenso im Falle von Erkrankungen eine tragende Rolle. Synthetische Phosphopeptide könnten in Form molekularer Sonden zur Charakterisierung dieser physiologisch fundamentalen Prozesse beitragen. Die radiopharmazeutische Forschung brachte in den letzten zwei Jahrzehnten zahlreiche radiomarkierte Peptide für das Pept
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Books on the topic "Cell-penetrating peptides (CPPs)"

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Langel, Ülo. CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0.

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Book chapters on the topic "Cell-penetrating peptides (CPPs)"

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Langel, Ülo. "Therapeutic Potential of CPPs." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_12.

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Langel, Ülo. "Cell-Translocation Mechanisms of CPPs." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_10.

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Langel, Ülo. "Kinetics of CPPs Cellular Uptake." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_8.

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Langel, Ülo. "Clinical Trials and Commercialization Using CPPs." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_11.

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Langel, Ülo. "Methods for Structural Studies of CPPs." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_7.

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Langel, Ülo. "Methods for Detection and Visualization of CPPs." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_6.

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Esposito, Cinzia, AiWei Tian, Mario Scrima, et al. "The role of Cell Penetrating Peptides (CPPs) in membrane lipid phase behavior: a novel aspect elucidating peptide-mediated delivery." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-73657-0_262.

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Langel, Ülo. "Introduction." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_1.

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Langel, Ülo. "Classes and Applications of Cell-Penetrating Peptides." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_2.

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Langel, Ülo. "Methods for CPP Functionalization." In CPP, Cell-Penetrating Peptides. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8747-0_3.

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