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Relevant bibliographies by topics / Cell-penetrating peptides (CPPs) / Dissertations / Theses

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Dissertations / Theses on the topic 'Cell-penetrating peptides (CPPs)'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Amoura, Mehdi. "Conception et étude de nouveaux peptides vecteurs cycliques." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066635/document.

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Les peptides vecteurs ou CPP sont de petits peptides, en général de taille inférieure à 30 acides aminés. Parmi les nombreux CPP décrits dans la littérature, les peptides riches en arginine ont fait l'objet d'une attention particulière. Plusieurs modifications chimiques du squelette peptidique conduisant à une distribution spatiale différente des groupes fonctionnels, ou encore l'introduction de chaînes aliphatiques ont été effectuées pour accroitre la capacité du peptide à traverser la membrane de la cellule. L'objectif de ce travail a été le développement de nouveaux peptides vecteurs cycliq

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2

Von, Zuben Eliete de Souza. "Lipossomas funcionalizados com peptídeos de transdução de membrana para administração intranasal de insulina no tratamento do diabetes mellitus /." Araraquara, 2019. http://hdl.handle.net/11449/183625.

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Orientador: Marlus Chorilli<br>Resumo: O diabetes mellitus (DM) é uma síndrome metabólica caracterizada por deficiência na produção/secreção pancreática de insulina e/ou resistência à ação do hormônio nos tecidos alvo, resultando em hiperglicemia. Diversas pesquisas têm desencadeado o desenvolvimento de novos sistemas de administração de insulina que possibilitem a utilização de vias alternativas à parenteral, com destaque à administração de insulina por via nasal. Esta via tem-se mostrado promissora, pois pode promover uma rápida absorção do fármaco e aumentar a sua biodisponibilidade. Entret

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3

Eiríksdóttir, Emelía. "Structures, toxicity and internalization of cell-penetrating peptides." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38607.

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Cellular internalization is a highly regulated process controlled by proteins in the plasma membrane. Large and hydrophilic compounds, in particular, face difficulties conquering the plasma membrane barrier in order to gain access to intracellular environment. This puts serious constrains on the drug industry since many drugs are hydrophilic. Several methods aiming at aiding the cellular internalization of otherwise impermeable compounds have therefore been developed. One such class, so-called cell-penetrating peptides (CPPs), emerged around twenty years ago. This group constitutes hundreds of

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4

Gomez, Jose A. "Development of Cell Penetrating Bax Inhibiting Peptides (BIP)." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1252025677.

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5

EL, Andaloussi Samir. "Vectorization of oligonucleotides with cell-penetrating peptides : Characterization of uptake mechanisms and cytotoxicity." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7167.

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The hydrophobic plasma membrane constitutes an indispensable barrier for cells in living animals. Albeit being pivotal for the maintenance of cells, the inability to cross the plasma membrane is still one of the major obstacles to overcome in order to progress current drug development. A group of substances, with restricted access to the interior of cells, which has shown great promise for future clinical use is oligonucleotides that are exploited to interfere with gene expression. Short interfering RNAs that are utilized to confer gene silencing and splice correcting oligonucleotides, applied

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6

Müller, Judith. "Detailed comparison of CPP's uptake properties for pro-apoptotic cargo delivery." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16589.

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Limitierend für pharmakologische Therapien ist oft die Unfähigkeit des Wirkstoffes, biologische Membranen zu überwinden, weswegen häufig Transportmoleküle wie z.B. zellpenetrierende Peptide (CPPs, cell penetrating peptides) benutzt werden. Von den über 100 beschriebenen CPPs wurde bisher nur eine kleine Anzahl systematisch verglichen, was die Auswahl des „richtigen“ CPPs für eine Anwendung erschwert. Ziel dieser vorliegenden Arbeit war es, das pro-apoptotische Peptid KLA mittels CPPs spezifisch in Krebszellen zu transportieren. Untersucht wurden: (I) Verschiedene CPPs in unterschiedlichen Ze

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7

Rosés, Subirós Cristina. "Solid-phase synthesis of cell-penetrating γ-peptide/antimicrobial peptide conjugates and of cyclic lipodepsipeptides derived from fengycins". Doctoral thesis, Universitat de Girona, 2016. http://hdl.handle.net/10803/393895.

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This thesis is focused on the development of synthetic approaches to obtain new bioactive peptides. The first part deals with the design of new antimicrobial peptide/cell-penetrating peptide conjugates as anticancer agents. Their conjugation enhanced the activity of the antimicrobial peptides against cancer cells while maintained their low toxicity. These compounds are interesting for the design of new anticancer agents. On the second part, a new versatile methodology for the synthesis of natural fengycin derivatives is described. Our strategy represents the first synthetic approach for the to

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8

Eriksson, Jonas. "Gene therapy tools: oligonucleotides and peptides." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-132271.

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Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. One of the many gene therapies developed so far is RNA-cleaving deoxyribozymes, short DNA oligonucleotides that specifically bind to and cleave RNA. Since the development of these synthetic catalytic oligonucleotides, the main way of determining their cleavage kinetics has been through the use of a laborious and error prone gel assay to quantify substrate and product at different time-points. We have developed two new methods for this purpose. The first on

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9

Tisseyre, Céline. "La maurocalcine : substance naturelle d'intérêt thérapeutique." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV047/document.

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La maurocalcine (MCa) est une toxine de 33 acides aminés initialement issue du venin du scorpionScorpio maurus palmatus, et est considérée comme faisant partie de la famille des CPP(Cell Penetrating Peptides) depuis de nombreuses années déjà. La MCa présente donc un intérêtthérapeutique certain dans le domaine de la délivrance intracellulaire de cargos, et lestravaux exposés ici cherchent à caractériser au mieux les propriétés de pénétration de la moléculenative ainsi que celle de certains de ses variants.Après avoir quantifié l’internalisation de plusieurs variants tronqués (linéaires), j’ai

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10

Richter, Susan. "Neue zellpenetrierende Phosphopeptide für die molekulare Bildgebung." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-68594.

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Im Kontext komplexer zellulärer Prozesse stellen Phosphopeptide essentielle bioaktive Verbindungen dar, die mit Phosphorylierungs- und Dephosphorylierungsreaktionen eng verbunden sind. Diese Prozesse sind in die Regulation nahezu jeder zellulären Funktion involviert und spielen damit ebenso im Falle von Erkrankungen eine tragende Rolle. Synthetische Phosphopeptide könnten in Form molekularer Sonden zur Charakterisierung dieser physiologisch fundamentalen Prozesse beitragen. Die radiopharmazeutische Forschung brachte in den letzten zwei Jahrzehnten zahlreiche radiomarkierte Peptide für das Pept

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11

Liu, Tao. "Development Of Cyclic Peptidyl Ligands Through A Combinatorial Library Approach." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306865559.

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12

Abdul, Fabien. "Développement et évaluation de nouvelles stratégies pour le traitement des hépatites B chroniques, dans le modèle du canard de Pékin infecté par le DHBV." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10284.

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Développement et évaluation de nouvelles stratégies pour le traitement des hépatites B chroniques, dans le modèle du canard de Pékin infecté par le DHBVL’infection chronique par le HBV est la cause majeure de cirrhose hépatique et de carcinome hépatocellulaire, conduisant à plus d’un million de décès chaque année. Le faible taux de réussite des thérapies actuelles des hépatites B montre la nécessité du recours à des méthodes thérapeutiques alternatives. Ainsi, nous avons étudié une stratégie pertinente reposant sur l’utilisation de molécules antisens (PNAs) couplées à des peptides perméabilisa

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13

Florian, Nagel. "Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F155-5.

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14

Saßen, Christoph. "A scanning ion conductance microscopy assay to investigate interactions between cell penetrating peptides and pore-suspending membranes." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0023-98FD-C.

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Die Rasterionenleitfähigkeitsmikroskopie (scanning ion conductance microscopy, SICM) stellt eine kontaktfreie Methode zur Ermittlung sowohl der Topographie als auch lokalen Ionenleitfähigkeit einer Oberfläche dar. Besonders vorteilhaft ist die Vermeidung mechanischer Beeinflussung bei der Untersuchung flexibler Strukturen, z.B. Lipiddoppelschichten wie Zellen oder künstlich erzeugter Lipidmembranen. Porenüberspannende Membranen (pore-suspending membranes, PSMs) verbinden als ein Beispiel für Modellsysteme eine hohe Stabilität mit lateraler Mobilität und dem Vorhandensein wässriger Kompartiment

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15

Číhařová, Barbora. "Studium účinku modifikace virových částic polyhistidinem na jejich intracelulární lokalizaci a dopravu genů do jádra." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446452.

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Viral vectors derived from mouse polyomavirus are a convenient tool for studying the targeted delivery of therapeutical agents into the cells and cellular organelles. Vectors derived from mouse polyomavirus face difficulties similar to other nanoparticles, as they often end up trapped inside an endosome where they are subsequently degraded. This diploma explored the potential of vector modifications, which have the potential to make the transport to the nucleus or cytosol more effective. This work had particularly focused on increasing the transduction efficiency by modifying particle's intern

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16

Richter, Susan. "Neue zellpenetrierende Phosphopeptide für die molekulare Bildgebung." Doctoral thesis, 2010. https://tud.qucosa.de/id/qucosa%3A25574.

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Abstract:

Im Kontext komplexer zellulärer Prozesse stellen Phosphopeptide essentielle bioaktive Verbindungen dar, die mit Phosphorylierungs- und Dephosphorylierungsreaktionen eng verbunden sind. Diese Prozesse sind in die Regulation nahezu jeder zellulären Funktion involviert und spielen damit ebenso im Falle von Erkrankungen eine tragende Rolle. Synthetische Phosphopeptide könnten in Form molekularer Sonden zur Charakterisierung dieser physiologisch fundamentalen Prozesse beitragen. Die radiopharmazeutische Forschung brachte in den letzten zwei Jahrzehnten zahlreiche radiomarkierte Peptide für das Pept

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