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Journal articles on the topic 'Cell proliferation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Fraser, Hamish M., Helen Wilson, Audrey Silvestri, Keith D. Morris, and Stanley J. Wiegand. "The Role of Vascular Endothelial Growth Factor and Estradiol in the Regulation of Endometrial Angiogenesis and Cell Proliferation in the Marmoset." Endocrinology 149, no. 9 (2008): 4413–20. http://dx.doi.org/10.1210/en.2008-0325.

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The present studies explore the roles of vascular endothelial growth factor (VEGF) and estradiol on angiogenesis and stromal and epithelial cell proliferation in the marmoset endometrium during the proliferative phase of the ovulatory cycle. At the start of the proliferative phase, marmosets were 1) treated with vehicle, 2) treated with a VEGF inhibitor (VEGF Trap, aflibercept), 3) ovariectomized, 4) ovariectomized and given replacement estradiol, or 5) treated with VEGF Trap and given replacement estradiol. The uterus was examined 10 d later in the late proliferative phase. Changes in endothe

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M. Baghdadi, Houry. "Effect of stem cells on genetic mutations and proliferation in squamous cell carcinoma." International Journal of Academic Research 6, no. 1 (2014): 192–97. http://dx.doi.org/10.7813/2075-4124.2014/6-1/a.25.

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Robey, H. L., P. S. Hiscott, and I. Grierson. "Cytokeratins and retinal epithelial cell behaviour." Journal of Cell Science 102, no. 2 (1992): 329–40. http://dx.doi.org/10.1242/jcs.102.2.329.

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The expression of cytokeratins 18 and 19 by human retinal pigment epithelial cells (HRPE) has been suspected of being associated with HRPE proliferation. We have investigated the involvement of these cytokeratin subtypes in the proliferative and migratory behaviour of cultured HRPE. Cell proliferation markers (bromodeoxyuridine and proliferating cell nuclear antigen) and the cytokeratins were identified using immunohistochemical techniques. In vitro, cytokeratins 18 and 19, as detected by the monoclonal antibodies RGE 53 and K4.62, were expressed in a subset of HRPE and this subset was signifi

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Chan, Ming Liang, Janka Petravic, Alexandra M. Ortiz, et al. "Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys." Proceedings of the Royal Society B: Biological Sciences 277, no. 1701 (2010): 3773–81. http://dx.doi.org/10.1098/rspb.2010.0972.

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Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections result in chronic virus replication and progressive depletion of CD4+ T cells, leading to immunodeficiency and death. In contrast, ‘natural hosts’ of SIV experience persistent infection with high virus replication but no severe CD4+ T cell depletion, and remain AIDS-free. One important difference between pathogenic and non-pathogenic infections is the level of activation and proliferation of CD4+ T cells. We analysed the relationship between CD4+ T cell number and proliferation in HIV, pathogenic SIV in macaq

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Kabraji, Sheheryar Kairas, Giorgio Gaglia, Danae Argyropoulou, et al. "Temporal and spatial topography of cell proliferation in cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3122. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3122.

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3122 Background: Tumors are complex ecosystems where exogenous and endogenous cues are integrated to either stimulate or inhibit cancer cell proliferation. However, the nature of these complex cell cycle states, their spatial organization, response to perturbation, and implications for clinical outcomes, are poorly characterized in tumor tissues. Methods: We used multiplexed tissue imaging to develop a robust classifier of proliferation, the multivariate proliferation index (MPI), using 513 unique tumors across five cancer types. Next, we used dimensionality reduction analysis to assess how th

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Tsunoda, Mikiya, Hiroyasu Aoki, Munetomo Takahashi, et al. "Abstract 5180: T cell receptor repertoire analysis revealed tissue tropism of tumor-reactive T-cell clones in cell cycle reporter mice." Cancer Research 83, no. 7_Supplement (2023): 5180. http://dx.doi.org/10.1158/1538-7445.am2023-5180.

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Abstract Tumor-reactive T cells are composed of clones with various TCRs, and each clone has different in vivo kinetics. By analyzing TCR repertoire of tumor and tumor-draining lymph node (dLN), we have demonstrated that Tumor-reactive CD8+ T cells can be classified into “dLN Major”, “Tumor Major”, and “Double Major” clones, which exhibited high frequency in the dLN, tumor, or both tissues. To investigate whether this classification was related to the tissue tropism in the proliferation of each clone, we here employed tumor-bearing Fucci transgenic mice expressing a fluorescent cell-cycle indi

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Levine, Richard, Magnus S. Agren, and Patricia M. Mertz. "Effect of Occlusion on Cell Proliferation during Epidermal Healing." Journal of Cutaneous Medicine and Surgery 2, no. 4 (1998): 193–98. http://dx.doi.org/10.1177/120347549800200403.

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Background: Occlusive dressings influence epithelization of superficial wounds by some unknown mechanism(s). Objective: The effects of occlusion on epidermal cell proliferation in two types of wounds were examined. Methods: Partial-thickness wounds and tape-stripped skin wounds were compared. An immunohistochemical technique, employing PC10 — a monoclonal antibody against proliferating cell nuclear antigen (PCNA) — was applied to formalin-fixed, paraffin-embedded porcine tissue sections. Results: The number of PC10-positive cells was low during the migratory phase, then increased to a peak of

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Deniz, Özdemir. "KAN0438757: A NOVEL PFKFB3 INHIBITOR THAT INDUCES PROGRAMMED CELL DEATH AND SUPPRESSES CELL MIGRATION IN NON-SMALL CELL LUNG CARCINOMA CELLS." Biotechnologia Acta 16, no. 5 (2023): 34–44. http://dx.doi.org/10.15407/biotech16.05.034.

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Aim. PFKFB3 is glycolytic activators that is overexpressed in human lung cancer and plays a crucial role in multiple cellular functions including programmed cell death. Despite the many small molecules described as PFKFB3 inhibitors, some of them have shown disappointing results in vitro and in vivo. On the other hand KAN0438757, selective and potent, small molecule inhibitor has been developed. However, the effects of KAN0438757, in non-small cell lung carcinoma cells remain unknown. Herein, we sought to decipher the effect of KAN0438757 on proliferation, migration, DNA damage, and programmed

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Chung, Hyunju, and Seungjoon Park. "Ghrelin regulates cell cycle-related gene expression in cultured hippocampal neural stem cells." Journal of Endocrinology 230, no. 2 (2016): 239–50. http://dx.doi.org/10.1530/joe-16-0126.

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We have previously demonstrated that ghrelin stimulates the cellular proliferation of cultured adult rat hippocampal neural stem cells (NSCs). However, little is known about the molecular mechanisms by which ghrelin regulates cell cycle progression. The purpose of this study was to investigate the potential effects of ghrelin on cell cycle regulatory molecules in cultured hippocampal NSCs. Ghrelin treatment increased proliferation assessed by CCK-8 proliferation assay. The expression levels of proliferating cell nuclear antigen and cell division control 2, well-known cell-proliferating markers

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10

Hall, Peter A. "Cell proliferation." Journal of Pathology 165, no. 4 (1991): 349–54. http://dx.doi.org/10.1002/path.1711650412.

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Lawrence, Ben, Simon Schimmack, Bernhard Svejda, et al. "Prognostication by multigene proliferative marker panel compared with Ki-67 in small-intestinal NENs." Journal of Clinical Oncology 30, no. 4_suppl (2012): 242. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.242.

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242 Background: Ki-67 is the major proliferative marker in clinical use to determine neuroendocrine neoplasm (NEN) prognosis. Ki-67 is unable to predict the outcome of SI-NENs, as the majority have a low (≤2) Ki-67%. Therefore, we aimed to identify a sensitive panel of proliferative markers using qRT-PCR to more accurately define the proliferation of these slow growing tumors. Methods: We identified genes with a mechanistic function in cell cycle progression that were over-expressed in RNA microarrays of SI-NENs (n=8) compared to adjacent normal tissue (n=4) (dCHIP, annotation databases). Timi

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Walter, L. M., P. A. W. Rogers, and J. E. Girling. "272. Progesterone stimulates endothelial cell proliferation, but not stromal cell proliferation, in mouse endometrium." Reproduction, Fertility and Development 17, no. 9 (2005): 112. http://dx.doi.org/10.1071/srb05abs272.

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Previous studies have suggested that progesterone stimulates stromal cell (SC) proliferation in the mouse endometrium1. However, these studies have not differentiated endothelial cells (EC) from other SC. In this study, we investigated the effects of progesterone on cellular proliferation in ovariectomised mouse endometrium. We hypothesised that progesterone would stimulate both SC and EC proliferation. One group of CBA × C57 mice (n = 6) were treated with a single injection of 100 ng of estradiol on day eight following ovariectomy, followed by a day with no treatment and three consecutive dai

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Moorthy, Rajesh Kannan, Chandhru Srinivasan, Sridharan Jayamohan, et al. "Knockdown of microRNA-375 suppresses cell proliferation and promotes apoptosis in human breast cancer cells." Indian Journal of Science and Technology 14, no. 43 (2021): 3199–209. http://dx.doi.org/10.17485/ijst/v14i43.1719.

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Kallak, Theodora K., and Kerstin Uvnäs-Moberg. "Oxytocin stimulates cell proliferation in vaginal cell line Vk2E6E7." Post Reproductive Health 23, no. 1 (2017): 6–12. http://dx.doi.org/10.1177/2053369117693148.

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Objective During and after menopause, the symptoms of vaginal atrophy cause great discomfort and necessitate effective treatment options. Currently, vaginally applied oxytocin is being investigated as a treatment for the symptoms of vaginal atrophy in postmenopausal women. To clarify the mechanisms behind oxytocins effects on vaginal atrophy, the present study investigated the effects of oxytocin on cell proliferation in the cells of the Vk2E6E7 line, a non-tumour vaginal cell line. The study also compared the effects of oxytocin with those of estradiol (E2). Study design The effects of both o

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Zhu, Su-Ning, Mian Chen, Jenny Jongstra-Bilen, and Myron I. Cybulsky. "GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions." Journal of Experimental Medicine 206, no. 10 (2009): 2141–49. http://dx.doi.org/10.1084/jem.20090866.

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The contribution of intimal cell proliferation to the formation of early atherosclerotic lesions is poorly understood. We combined 5-bromo-2′-deoxyuridine pulse labeling with sensitive en face immunoconfocal microscopy analysis, and quantified intimal cell proliferation and Ly-6Chigh monocyte recruitment in low density lipoprotein receptor–null mice. Cell proliferation begins in nascent lesions preferentially at their periphery, and proliferating cells accumulate in lesions over time. Although intimal cell proliferation increases in parallel to monocyte recruitment as lesions grow, proliferati

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Stoeber, Kai, Thea D. Tlsty, Lisa Happerfield, et al. "DNA replication licensing and human cell proliferation." Journal of Cell Science 114, no. 11 (2001): 2027–41. http://dx.doi.org/10.1242/jcs.114.11.2027.

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The convergence point of growth regulatory pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly of pre-replicative complexes resulting in chromatin being ‘licensed’ for DNA replication in the subsequent S phase. We have analysed regulation of the pre-replicative complex proteins ORC, Cdc6, and MCM in cycling and non-proliferating quiescent, differentiated and replicative senescent human cells. Moreover, a human cell-free DNA replication system has been exploited to study the replicative capacity of nuclei and cytosolic extracts pre

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Yuko, Murase, Fesseha Meseret, Abbaspour Nazanin, and Young Hong Mee. "Watermelon Powder Supplementation Reduces Colonic Cell Proliferation by Upregulating p21Waf1/Cip1 Expression." Current Developments in Nutrition 4, Supplement_2 (2020): 340. http://dx.doi.org/10.1093/cdn/nzaa044_039.

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Abstract Objectives Watermelon is high in L-citrulline, a precursor for L-arginine, which in turn may reduce the risk of colorectal cancer (CRC). Research has shown that L-arginine inhibits the hyperproliferation of colorectal tumor cells as a marker for CRC. The objective of this study was, therefore, to examine the effects of watermelon powder supplementation on colonic cell proliferation and their gene expression. The hypothesis was that watermelon powder supplementation would reduce CRC risk by regulating colonic expression of genes related to epithelial cell proliferation. Methods Thirty-

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Pabla, Sarabjot, Jason Zhu, Matthew Labriola, et al. "Cell proliferation as a biomarker for response to immune checkpoint inhibitors in highly inflamed renal cell carcinoma." Journal of Clinical Oncology 37, no. 8_suppl (2019): 61. http://dx.doi.org/10.1200/jco.2019.37.8_suppl.61.

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61 Background: Cell proliferation is an important marker of survival in many tumors and we hypothesized that this attribute could be related to response to immune checkpoint inhibitors in RCC. Previously we reported (SITC 2018) moderately proliferative lung cancer has a much higher response rate than either poorly or highly proliferative tumors. Methods: 69 FFPE tumor samples of RCC were evaluated by RNA-seq to measure transcript levels of 394 immune related genes, including 10 related to cell proliferation (BUB1, CCNB2, CDK1, CDKN3, FOXM1, KIAA0101, MAD2L1, MELK, MKI67, TOP2A). Cell prolifera

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Sambasiva Rao, M., and Janardan K. Reddy. "The Relevance of Peroxisome Proliferation and Cell Proliferation in Peroxisome Proliferator-Induced Hepatocarcinogenesis." Drug Metabolism Reviews 21, no. 1 (1989): 103–10. http://dx.doi.org/10.3109/03602538909029957.

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Berman, J. E., and S. Zolla-Pazner. "Control of B cell proliferation: inhibition of responses to B cell mitogens induced by plasma cell tumors." Journal of Immunology 134, no. 5 (1985): 2872–78. http://dx.doi.org/10.4049/jimmunol.134.5.2872.

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Abstract A multitude of factors has been described that positively and negatively regulate B cell proliferation. A model system for the study of negative control of B cell function is provided by mice bearing plasmacytomas (PC-mice). In PC-mice, the primary immune response, as measured by development of antibody-forming cells (AFC), is severely suppressed. The present report specifically identifies a block in B cell proliferation as the apparent cause of this reduction in AFC production. Thus, the proliferative response of B cells from the spleens of PC-mice (PC-spleens) was significantly impa

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Hernández-Núñez, Ismael, Ana Quelle-Regaldie, Laura Sánchez, Fátima Adrio, Eva Candal, and Antón Barreiro-Iglesias. "Decline in Constitutive Proliferative Activity in the Zebrafish Retina with Ageing." International Journal of Molecular Sciences 22, no. 21 (2021): 11715. http://dx.doi.org/10.3390/ijms222111715.

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It is largely assumed that the teleost retina shows continuous and active proliferative and neurogenic activity throughout life. However, when delving into the teleost literature, one finds that assumptions about a highly active and continuous proliferation in the adult retina are based on studies in which proliferation was not quantified in a comparative way at the different life stages or was mainly studied in juveniles/young adults. Here, we performed a systematic and comparative study of the constitutive proliferative activity of the retina from early developing (2 days post-fertilisation)

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Nadasdy, T., Z. Laszik, K. E. Blick, L. D. Johnson, and F. G. Silva. "Proliferative activity of intrinsic cell populations in the normal human kidney." Journal of the American Society of Nephrology 4, no. 12 (1994): 2032–39. http://dx.doi.org/10.1681/asn.v4122032.

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The proliferative activity of various normal human renal cell populations is unknown. Recently, antibodies to cell proliferation-associated nuclear proteins, such as proliferating cell nuclear antigen (PCNA) and KI-67, which are applicable to archival paraffin sections, became available. With antibodies to PCNA and Ki-67 after microwave pretreatment of the paraffin sections, the proliferation indexes (ratio of positive nuclei with PCNA and Ki-67 antibodies/all nuclei counted x 100, i.e. percentage of positive cells) of 12 different intrinsic renal cell populations in 20 normal human kidneys ha

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Potten, Christopher S., and Markus Loeffler. "Epidermal cell proliferation." Virchows Archiv B Cell Pathology Including Molecular Pathology 53, no. 1 (1987): 279–85. http://dx.doi.org/10.1007/bf02890254.

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Loeffler, M., C. S. Potten, and H. E. Wichmann. "Epidermal cell proliferation." Virchows Archiv B Cell Pathology Including Molecular Pathology 53, no. 1 (1987): 286–300. http://dx.doi.org/10.1007/bf02890255.

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Xing, Yiding, Shobha H. Ganji, Jung W. Noh, and Vaijinath S. Kamanna. "Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth." American Journal of Physiology-Renal Physiology 287, no. 6 (2004): F1250—F1257. http://dx.doi.org/10.1152/ajprenal.00342.2003.

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Lysophosphatidic acid (LPA), a major member of the bioactive lysophospholipids in serum, possesses diverse physiological activities including cell proliferation. Recently, three endothelial differentiation gene (EDG) family receptors, including EDG-2 (LPA1), EDG-4 (LPA2), and EDG-7 (LPA3), have been identified as LPA receptors. The role of LPA and their receptors in mesangial cell physiology is not clearly understood. This study examined the expression profile of EDG receptors as a function of cell density and the participation of EDG receptors in human mesangial cell proliferation by LPA. We

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Wadham, C., J. R. Gamble, M. A. Vadas, and Y. Khew-Goodall. "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation." Journal of Cell Science 113, no. 17 (2000): 3117–23. http://dx.doi.org/10.1242/jcs.113.17.3117.

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Pez is a non-transmembrane tyrosine phosphatase with homology to the FERM (4.1, ezrin, radixin, moesin) family of proteins. The subcellular localisation of Pez in endothelial cells was found to be regulated by cell density and serum concentration. In confluent monolayers Pez was cytoplasmic, but in cells cultured at low density Pez was nuclear, suggesting that it is a nuclear protein in proliferating cells. This notion is supported by the loss of nuclear Pez when cells are serum-starved to induce quiescence, and the rapid return of Pez to the nucleus upon refeeding with serum to induce prolife

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Collesi, Chiara, Lorena Zentilin, Gianfranco Sinagra, and Mauro Giacca. "Notch1 signaling stimulates proliferation of immature cardiomyocytes." Journal of Cell Biology 183, no. 1 (2008): 117–28. http://dx.doi.org/10.1083/jcb.200806091.

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The identification of the molecular mechanisms controlling cardiomyocyte proliferation during the embryonic, fetal, and early neonatal life appears of paramount interest in regard to exploiting this information to promote cardiac regeneration. Here, we show that the proliferative potential of neonatal rat cardiomyocytes is powerfully stimulated by the sustained activation of the Notch pathway. We found that Notch1 is expressed in proliferating ventricular immature cardiac myocytes (ICMs) both in vitro and in vivo, and that the number of Notch1-positive cells in the heart declines with age. Not

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Molochkova, Yu V., A. N. Khlebnikova, V. A. Molochkov, L. E. Gurevich, and A. V. Molochkov. "Comparative study of Ki67 protein expression in oral lichen planus and leukoplakia." Vestnik dermatologii i venerologii 94, no. 4 (2018): 15–20. http://dx.doi.org/10.25208/0042-4609-2018-94-4-15-20.

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Oral lichen planus (OLP) is included in the category of potentially malignant diseases. Benign processes are differentiated from malignant ones by the nature of cell proliferative activity. The aim of the present study was the comparative study of proliferative activity in OLP and leuk oplakia cells, as well as the cells of oral squamous cell carcinoma.Materials and methods. Biopsy specimens from 16 patients with OPL, 13 with leukoplakia, and 7 with oral squamous cell carcinoma were investigated. Immunohistochemical studies were performed using Ki67 monoclonal antibodies.Results. The average K

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Yoshimura, A., K. Inui, T. Nemoto, et al. "Simvastatin suppresses glomerular cell proliferation and macrophage infiltration in rats with mesangial proliferative nephritis." Journal of the American Society of Nephrology 9, no. 11 (1998): 2027–39. http://dx.doi.org/10.1681/asn.v9112027.

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Inhibition of 3-hydro-3-methylglutaryl coenzyme A reductase inhibits the production of mevalonate and has been shown to suppress proliferation in many cell types. Therefore, 3-hydro-3-methylglutaryl coenzyme A reductase inhibitors may have a beneficial effect in glomerular disease, because glomerular cell proliferation is a central feature in the active glomerular injury. This study examines the effect of simvastatin on glomerular pathology in a rat mesangial proliferative glomerulonephritis (GN) induced by anti-thymocyte antibody (anti-Thy 1.1 GN). There was no difference in the degree of the

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Green, S. E., P. Chapman, J. Burn, et al. "Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer." Gut 43, no. 1 (1998): 85–92. http://dx.doi.org/10.1136/gut.43.1.85.

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Background—Despite the recent discovery of four genes responsible for up to 90% of all cases of hereditary non-polyposis colorectal cancer (HNPCC), there will still be families in whom predictive testing is not possible. A phenotypic biomarker would therefore be useful. An upwards shift of the proliferative compartment in colonic crypts is reported to be one of the earliest changes in premalignant mucosa.Aims—To assess the role of crypt cell proliferation as a phenotypic biomarker in HNPCC.Patients—Thirty five patients at 50% risk of carrying the HNPCC gene (21 of whom subsequently underwent p

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Metz, Ethan P., Phillip J. Wilder, Tessa M. Popay, et al. "Elevating SOX2 Downregulates MYC through a SOX2:MYC Signaling Axis and Induces a Slowly Cycling Proliferative State in Human Tumor Cells." Cancers 14, no. 8 (2022): 1946. http://dx.doi.org/10.3390/cancers14081946.

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Slowly cycling/infrequently proliferating tumor cells present a clinical challenge due to their ability to evade treatment. Previous studies established that high levels of SOX2 in both fetal and tumor cells restrict cell proliferation and induce a slowly cycling state. However, the mechanisms through which elevated SOX2 levels inhibit tumor cell proliferation have not been identified. To identify common mechanisms through which SOX2 elevation restricts tumor cell proliferation, we initially performed RNA-seq using two diverse tumor cell types. SOX2 elevation in both cell types downregulated M

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Xie, Xiangfei, and Koichi Araki. "Translation inhibitor PDCD4 promotes CD8+ T cell proliferation during antiviral response." Journal of Immunology 210, no. 1_Supplement (2023): 148.03. http://dx.doi.org/10.4049/jimmunol.210.supp.148.03.

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Abstract CD8+ T cell clonal expansion is critical for controlling intracellular infections and tumors. Thus, unravelling the mechanisms that regulate CD8+ T cell proliferation are imperative to improve vaccine design and immunotherapy. However, the molecular mechanisms that govern CD8+ T cell proliferation are still not fully understood. PDCD4 (Programmed cell death 4) was shown to inhibit translation by sequestering mRNA helicase eIF4A, which leads to translation inhibition of genes involved in cell proliferation. Despite the well-characterized anti-proliferative role of PDCD4, our studies su

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Jiang, Zhisheng, Serena F. Generoso, Marta Badia, Bernhard Payer, and Lucas B. Carey. "A conserved expression signature predicts growth rate and reveals cell & lineage-specific differences." PLOS Computational Biology 17, no. 11 (2021): e1009582. http://dx.doi.org/10.1371/journal.pcbi.1009582.

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Isogenic cells cultured together show heterogeneity in their proliferation rate. To determine the differences between fast and slow-proliferating cells, we developed a method to sort cells by proliferation rate, and performed RNA-seq on slow and fast proliferating subpopulations of pluripotent mouse embryonic stem cells (mESCs) and mouse fibroblasts. We found that slowly proliferating mESCs have a more naïve pluripotent character. We identified an evolutionarily conserved proliferation-correlated transcriptomic signature that is common to all eukaryotes: fast cells have higher expression of ge

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Scoggins, Charles R., Ingrid M. Meszoely, Michihiko Wada, Anna L. Means, Liying Yang, and Steven D. Leach. "p53-Dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 4 (2000): G827—G836. http://dx.doi.org/10.1152/ajpgi.2000.279.4.g827.

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The mechanisms linking acinar cell apoptosis and ductal epithelial proliferation remain unknown. To determine the relationship between these events, pancreatic duct ligation (PDL) was performed on p53(+/+) and p53(−/−) mice. In mice bearing a wild-type p53 allele, PDL resulted in upregulation of p53 protein in both acinar cells and proliferating duct-like epithelium. In contrast, upregulation of Bcl-2 occurred only in duct-like epithelium. Both p21WAF1/CIP1 and Bax were also upregulated in duct-ligated lobes. After PDL in p53(+/+) mice, acinar cells underwent widespread apoptosis, while duct-l

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Yoshioka, K., A. Mori, K. Taniguchi, and K. Mutoh. "Cell Proliferation Activity of Proliferating Bile Duct after Bile Duct Ligation in Rats." Veterinary Pathology 42, no. 3 (2005): 382–85. http://dx.doi.org/10.1354/vp.42-3-382.

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The cell proliferation activity of proliferating bile ducts produced by bile duct ligation (BDL) in rats was examined histologically, immunohistochemically, and ultrastructurally. Proliferating bile ducts, which were similar to normal bile ducts, increased with time after BDL. The cell proliferation activity of proliferating bile ducts, measured using proliferating-cell nuclear antigen and 5-bromo-2′-deoxyuridine antibodies, tended to be high at 1 and 3 days after BDL and decreased progressively at 2 to 4 weeks after BDL. On the other hand, α-smooth muscle actin-positive myofibroblast-like cel

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Marinos, Rebecca S., Wei Zhang, Guoyao Wu, Katherine A. Kelly, and Cynthia J. Meininger. "Tetrahydrobiopterin levels regulate endothelial cell proliferation." American Journal of Physiology-Heart and Circulatory Physiology 281, no. 2 (2001): H482—H489. http://dx.doi.org/10.1152/ajpheart.2001.281.2.h482.

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Vascular abnormalities, including altered angiogenesis, are major factors contributing to the morbidity and mortality of diabetes. We hypothesized that impaired angiogenesis in diabetes results from decreased tetrahydrobiopterin (BH4)-dependent synthesis of nitric oxide (NO) by endothelial cells (EC). To test this hypothesis, we utilized EC from spontaneously diabetic BB (BBd) and nondiabetes-prone BB (BBn) rats to investigate the link between BH4 and EC proliferation. There were significant decreases in the proliferation rate and expression of proliferating cell nuclear antigen in BBd versus

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Rindone, Gustavo Marcelo, Agostina Gorga, Mariana Regueira, et al. "Metformin counteracts the effects of FSH on rat Sertoli cell proliferation." Reproduction 156, no. 2 (2018): 93–101. http://dx.doi.org/10.1530/rep-18-0233.

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Metformin (MET) is one of the most widely used anti-hyperglycemic agents for treating patients with type 2 diabetes and it has started to be used in pediatric population at ages when Sertoli cells are still proliferating. It is well known that follicle-stimulating hormone (FSH) is the major Sertoli cell mitogen. The aim of the study is to investigate a possible effect of MET, which has been shown to have anti-proliferative properties, on FSH regulation of postnatal Sertoli cell proliferation and on the molecular mechanisms involved in this regulation. The present study was performed in eight-d

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Dunlap, Kent D., Alex Tran, Michael A. Ragazzi, Rüdiger Krahe, and Vielka L. Salazar. "Predators inhibit brain cell proliferation in natural populations of electric fish, Brachyhypopomus occidentalis." Proceedings of the Royal Society B: Biological Sciences 283, no. 1824 (2016): 20152113. http://dx.doi.org/10.1098/rspb.2015.2113.

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Compared with laboratory environments, complex natural environments promote brain cell proliferation and neurogenesis. Predators are one important feature of many natural environments, but, in the laboratory, predatory stimuli tend to inhibit brain cell proliferation. Often, laboratory predatory stimuli also elevate plasma glucocorticoids, which can then reduce brain cell proliferation. However, it is unknown how natural predators affect cell proliferation or whether glucocorticoids mediate the neurogenic response to natural predators. We examined brain cell proliferation in six populations of

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Z, Ding. "Concentration Polarization of Ox-LDL and Its Effect on Cell Proliferation and Apoptosis in Human Endothelial Cells." Journal of Cardiology and Cardiovascular Medicine 1, no. 1 (2016): 011–18. http://dx.doi.org/10.29328/journal.jccm.1001003.

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RAVENNA, L., L. SALVATORI, S. MORRONE, et al. "Effects of Triptorelin, a Gonadotropin‐Releasing Hormone Agonist, on the Human Prostatic Cell Lines PC3 and LNCaP." Journal of Andrology 21, no. 4 (2000): 549–57. http://dx.doi.org/10.1002/j.1939-4640.2000.tb02120.x.

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ABSTRACT: Some analogues of gonadotropin‐releasing hormone (GnRH) influence the in vitro proliferation of cultured human cells by complex interactions that are only partially understood. This study explored the effect of Triptorelin, a GnRH agonist, on the LNCaP and PC3 prostatic cell lines, which are, respectively, responsive and unresponsive to androgen stimulation. The toxicity and cell cycle modifications induced by the drug were investigated by FACScan analysis; the effect on cell proliferation in different culture conditions was determined by counting in a Burker chamber; and the express

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Bai, Jiuxu, Wenjia Geng, Yan Mei, et al. "Effect of Huaier On the Proliferation of Mesangial Cells in Anti-Thy-1 Nephritis." Cellular Physiology and Biochemistry 42, no. 6 (2017): 2441–52. http://dx.doi.org/10.1159/000480198.

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Background/Aims: To determine whether an aqueous extract of Trametes robiniophila Murr. (Huaier) suppresses anti-Thy-1 mesangial proliferative glomerulonephritis (MsPGN) in vivo and platelet-derived growth factor (PDGF)-BB–induced mesangial cell proliferation in vitro. Methods: Male Wistar rats were randomly categorized into 5 groups: Sham, Thy-1, and 3 Huaier-treated groups (low, medium, and high dose). Two weeks after treatment, urinary proteins were quantified and renal pathological changes were examined. MAX interactor 1 (Mxi-1) and proliferating cell nuclear antigen (PCNA) expression leve

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Martín-Sanz, Raquel, José María Sayagués, Pilar García-Cano, et al. "TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours." Dermatopathology 8, no. 2 (2021): 147–58. http://dx.doi.org/10.3390/dermatopathology8020021.

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Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on TP53 and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Based on this assumption, but also taking into account the close relationship between the sebaceous ducts and the external root sheat

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Petrov, S. V., R. N. Kulagin, D. E. Tsyplakov, et al. "Markers of tumor cell proliferation in cancerous tumors of the larynx." Kazan medical journal 81, no. 4 (2022): 265–68. http://dx.doi.org/10.17816/kazmj99817.

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The cell proliferative process in the larynx cancer is studied. Contrary to the classical mitotic index the Ki-67 and PCNA indices are reliable and reproducible on the clinical material by the proliferative cell activity indices of the larynx tumors. There is a reverse connection between the proliferation index in cells of the squamous larynx cancer and the tumor differentiation. The direct correlation of the cell proliferation index of the squamous laxynx cancer with the disease stage is revealed. The preoperative radiation therapy significantly decreases the cell proliferation rates of the s

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Kong, Chunfang. "Schisandrin B Suppressed the Proliferation of MM Cell Lines Via IL-6." Cell & Cellular Life Sciences Journal 8, no. 2 (2023): 1–8. http://dx.doi.org/10.23880/cclsj-16000189.

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Background: Multiple myeloma (MM) is a hematologic malignancy. Schizandrin B (Sch B) is one of the main dibenzocyclooctadiene lignans which is found in schisandra chinensis. Sch B has been previously demonstrated to exhibit antitumor properties. However, the effect of Sch B on MM remains nuclear. Materials and Methods: The impact of Sch B on the proliferation of MM cell lines was determined by CCK-8 assay. The cell cycle and apoptosis of MM cell lines were evaluated by flow cytometry. RT-PCR to identify the effect of Sch B on the chemokines CCL2, CCL3 and CCL14 in MM cell lines. IL-6 and VEGF

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Wakatsuki, Y., M. F. Neurath, E. E. Max, and W. Strober. "The B cell-specific transcription factor BSAP regulates B cell proliferation." Journal of Experimental Medicine 179, no. 4 (1994): 1099–108. http://dx.doi.org/10.1084/jem.179.4.1099.

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The B cell-specific activator protein (BSAP) is a DNA-binding transcription factor expressed in pro-B, pre-B, and mature B cells, but not in plasma cells. In this study, we explored the role of BSAP in B cell function by assessing how the content of this protein varies in cells driven by proliferative stimuli and, conversely, how artificial manipulation of BSAP activity affects cell proliferation. We found that BSAP activity of nuclear extracts increased when B cells were activated by mitogen (lipopolysaccharide [LPS]), antigen receptor-mediated signaling (surface immunoglobulin D [IgD] cross-

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Boerner, Brian P., Nicholas M. George, Natalie M. Targy та Nora E. Sarvetnick. "TGF-β Superfamily Member Nodal Stimulates Human β-Cell Proliferation While Maintaining Cellular Viability". Endocrinology 154, № 11 (2013): 4099–112. http://dx.doi.org/10.1210/en.2013-1197.

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In an effort to expand human islets and enhance allogeneic islet transplant for the treatment of type 1 diabetes, identifying signaling pathways that stimulate human β-cell proliferation is paramount. TGF-β superfamily members, in particular activin-A, are likely involved in islet development and may contribute to β-cell proliferation. Nodal, another TGF-β member, is present in both embryonic and adult rodent islets. Nodal, along with its coreceptor, Cripto, are pro-proliferative factors in certain cell types. Although Nodal stimulates apoptosis of rat insulinoma cells (INS-1), Nodal and Cript

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Kang, Bijun, Yizuo Cai, Zhuoxuan Jia, et al. "Cell-Free Fat Extract Prevents Vaginal Atrophy in an Ovariectomized Model by Promoting Proliferation of Vaginal Keratinocytes and Neovascularization." Aesthetic Surgery Journal 42, no. 1 (2021): NP55—NP68. http://dx.doi.org/10.1093/asj/sjab366.

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Abstract Background Most perimenopausal and postmenopausal women experience estrogen deficiency–induced vaginal atrophy. However, estrogen replacement therapy has contraindications and side effects, which makes it unsuitable for most women. Cell-free fat extract (CEFFE) has pro-proliferative and proangiogenic tissue regeneration activities. Objectives The purpose of this study was to evaluate the effect of topical application of CEFFE in the vagina and the effect of CEFFE on vaginal keratinocytes. Methods Ovariectomized mice were treated with CEFFE via vaginal topical application for 2 weeks.

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Proust, J. J., M. A. Buchholz, and A. A. Nordin. "A "lymphokine-like" soluble product that induces proliferation and maturation of B cells appears in the serum-free supernatant of a T cell hybridoma as a consequence of mycoplasmal contamination." Journal of Immunology 134, no. 1 (1985): 390–96. http://dx.doi.org/10.4049/jimmunol.134.1.390.

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Abstract The serum-free supernatant of a cloned murine T cell hybridoma supports the proliferation and maturation to Ig secretion of purified B cells (mu+ cells) from BALB/c nu/nu mice, but has no effect on the proliferation of nylon wool-selected BALB/c nu/+ splenic T cells. Although the supernatant activates B cells without co-stimulation, it synergizes with anti-mu for the proliferative response. The induction of B cell proliferation and maturation to Ig secretion is directly related to contamination of the hybridoma by Mycoplasma hyorhinis. Hybridoma cells freed of mycoplasma by detergent

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Glenn, Sean T., Sarabjot Pabla, Jason Zhu, et al. "Cell proliferation as a biomarker for response to immune checkpoint inhibitors in PD-L1 negative renal cell carcinoma." Journal of Clinical Oncology 37, no. 8_suppl (2019): 62. http://dx.doi.org/10.1200/jco.2019.37.8_suppl.62.

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62 Background: Cell proliferation is an important marker of survival in many tumors, and we hypothesized that this attribute could be related to response to immune checkpoint inhibitors (ICIs) in RCC. Previously we reported (SITC 2018) that moderately proliferative lung cancer have a much higher response rate than either poorly or highly proliferative tumors. Methods: 69 FFPE RCC tumor samples were evaluated by RNA-seq to measure transcript levels of 394 immune related genes. Cell proliferation was defined as the mean mRNA expression of 10 genes (BUB1, CCNB2, CDK1, CDKN3, FOXM1, KIAA0101, MAD2

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Barbosa-Desongles, Anna, Cristina Hernández, Rafael Simó, and David M. Selva. "Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes." American Journal of Physiology-Cell Physiology 305, no. 3 (2013): C355—C359. http://dx.doi.org/10.1152/ajpcell.00019.2013.

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Evidence from the literature suggests that testosterone plays an important role in visceral fat accumulation since both men and women with hyperandrogenism accumulate more adipose tissue in the abdominal cavity than healthy women. However, the underlying mechanisms remain to be elucidated. To shed light on this issue, we have used an in vitro approach to examine the effect of testosterone on human visceral preadipocyte proliferation. Our results showed that testosterone treatment significantly increased proliferation of human visceral preadipocytes in proliferation assays using flow cytometric

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