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Journal articles on the topic 'Cell receptors'

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1

Tibrewal, Richa, Reynoldly Kharsyntiew, Farida Dawood, and Archana Sharma. "A REVIEW ON G-PROTEIN COUPLED RECEPTOR." International Journal of Current Pharmaceutical Review and Research 13, no. 04 (2021): 01–09. https://doi.org/10.5281/zenodo.12664417.

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AbstractG protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domainreceptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linkedreceptors (GPLR), constitute a large protein family of receptors that detect molecules outsidethe cell and activate internal signal transduction pathways and, ultimately, cellular responses.Coupling with G proteins, they are called seven-transmembrane receptors because they passthrough the cell membrane seven times. G protein–coupled receptors are found only ineukaryotes, including yeast, choanof
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2

Steverding, Dietmar. "Cycle Numbers of Cell Surface Recycling Receptors." Receptors 2, no. 2 (2023): 160–65. http://dx.doi.org/10.3390/receptors2020010.

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The cycle number (nc) of a recycling receptor is defined as the average number of round trips (cell surface–endosome–cell surface) the receptor can make before it is degraded. This characteristic parameter of recycling receptors can be easily determined from the receptor’s half-life (t½, the time in which 50% of the receptor is degraded) and cycling time (Tc, the time a receptor needs to complete a round trip). Relationship analyses revealed that nc increases linearly with increasing t½ and decreases exponentially with increasing Tc. For commonly observed t½ and Tc values, it was calculated th
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3

Gao, Yin, Xue Luan, Jacob Melamed, and Inka Brockhausen. "Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death." Cells 10, no. 5 (2021): 1252. http://dx.doi.org/10.3390/cells10051252.

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Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated. This review discusses receptor glycosylation and the known roles of glycans on the functions of receptors expressed in diverse cell types. We included growth factor receptors that have an intracellular tyrosine kinase domain, growth factor receptors that have a serine/threonine kinase domain, and cell-death-inducing receptors. N- and O-glycans have a wide range of functions including roles in receptor conformation, ligand binding, oligomerizat
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4

Thermos, K., M. D. Meglasson, J. Nelson, K. M. Lounsbury, and T. Reisine. "Pancreatic beta-cell somatostatin receptors." American Journal of Physiology-Endocrinology and Metabolism 259, no. 2 (1990): E216—E224. http://dx.doi.org/10.1152/ajpendo.1990.259.2.e216.

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The characteristics of somatostatin (SRIF) receptors in rat pancreatic beta-cells were investigated using rat islets and the beta-cell line HIT-T15 (HIT). The biochemical properties of the SRIF receptors were examined with 125I-labeled des-Ala-1,Gly-2-desamino-Cys-3-[Tyr-11]- dicarba3,14-somatostatin (CGP 23996). 125I-CGP 23996 bound to SRIF receptors in HIT cells with high affinity and in a saturable manner. The binding of 125I-CGP 23996 to SRIF receptors was blocked by SRIF analogues with a rank order of potency of somatostatin 28 (SRIF-28) greater than D-Trp-8-somatostatin greater than soma
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5

Gao, Zihan. "The structure and function of cell membrane receptor." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 441–47. http://dx.doi.org/10.54097/bncesw47.

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Cell membrane receptors play a key role in regulating cell communication and maintaining cell homeostasis. This paper explores the complex relationship between the structure and function of cell membrane receptors, and elucidates their multiple roles in signal transduction, cellular response, and disease pathways. Different receptor types, including as G protein-coupled receptors (GPCRs), ligand-gated ion channels, receptor tyrosine kinases (RTKs), and cytokine receptors, have varied structural properties that serve different biological purposes and are necessary for cell division, proliferati
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6

Atif, Muhmmad, Abdullah Alsrhani, Farrah Naz, et al. "Targeting Adenosine Receptors in Neurological Diseases." Cellular Reprogramming 23, no. 2 (2021): 57–72. http://dx.doi.org/10.1089/cell.2020.0087.

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7

Uings, I. J. "Cell receptors and cell signalling." Molecular Pathology 53, no. 6 (2000): 295–99. http://dx.doi.org/10.1136/mp.53.6.295.

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8

Desforges, Jane F. "T-Cell Receptors." New England Journal of Medicine 313, no. 9 (1985): 576–77. http://dx.doi.org/10.1056/nejm198508293130909.

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9

Abbas, Atheir, and Bryan L. Roth. "Electrifying cell receptors." Nature Nanotechnology 3, no. 10 (2008): 587–88. http://dx.doi.org/10.1038/nnano.2008.292.

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10

Deller, M. "Cell surface receptors." Current Opinion in Structural Biology 10, no. 2 (2000): 213–19. http://dx.doi.org/10.1016/s0959-440x(00)00072-5.

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11

Primi, Daniele. "T cell receptors." FEBS Letters 384, no. 3 (1996): 296. http://dx.doi.org/10.1016/s0014-5793(96)90958-8.

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12

Ryan, Una S. "Endothelial cell receptors." Advanced Drug Delivery Reviews 4, no. 1 (1989): 65–85. http://dx.doi.org/10.1016/0169-409x(89)90038-0.

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13

Caccia, Nicolette, and Tak W. Mak. "T cell receptors." American Journal of Medicine 85, no. 6 (1988): 9–11. http://dx.doi.org/10.1016/0002-9343(88)90371-3.

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14

Lanier, Lewis L. "NK CELL RECEPTORS." Annual Review of Immunology 16, no. 1 (1998): 359–93. http://dx.doi.org/10.1146/annurev.immunol.16.1.359.

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15

Viney, Joanne L. "T Cell receptors." Immunology Today 17, no. 7 (1996): 346–47. http://dx.doi.org/10.1016/0167-5699(96)80797-3.

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16

Mapstone, Timothy B. "Cell Surface Receptors." Pediatric Neurosurgery 27, no. 2 (1997): 57–62. http://dx.doi.org/10.1159/000121228.

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17

Ingber, Arieh. "Langerhans Cell Receptors." Dermatologic Clinics 25, no. 4 (2007): 559–62. http://dx.doi.org/10.1016/j.det.2007.06.019.

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18

Jaremko, William J., Zhen Huang, Wei Wen, Andrew Wu, Nicholas Karl, and Li Niu. "Identification and characterization of RNA aptamers: A long aptamer blocks the AMPA receptor and a short aptamer blocks both AMPA and kainate receptors." Journal of Biological Chemistry 292, no. 18 (2017): 7338–47. http://dx.doi.org/10.1074/jbc.m116.774752.

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AMPA and kainate receptors, along with NMDA receptors, represent different subtypes of glutamate ion channels. AMPA and kainate receptors share a high degree of sequence and structural similarities, and excessive activity of these receptors has been implicated in neurological diseases such as epilepsy. Therefore, blocking detrimental activity of both receptor types could be therapeutically beneficial. Here, we report the use of an in vitro evolution approach involving systematic evolution of ligands by exponential enrichment with a single AMPA receptor target (i.e. GluA1/2R) to isolate RNA apt
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19

Lucianò, Anna Maria, Francesca Mattei, Elisa Damo, Elisa Panzarini, Luciana Dini, and Ada Maria Tata. "Effects mediated by M2 muscarinic orthosteric agonist on cell growth in human neuroblastoma cell lines." Pure and Applied Chemistry 91, no. 10 (2019): 1641–50. http://dx.doi.org/10.1515/pac-2018-1224.

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Abstract The role of muscarinic receptors has been largely documented over the past few decades. Recently we demonstrated that the activation of M2 muscarinic receptors arrested cell proliferation and induced apoptosis in glioblastoma and in other tumour types. This paper aims to evaluate the expression of the M2 muscarinic receptor subtypes in different neuroblastoma cell lines and its role in the control of cell proliferation and survival. Neuroblastoma is the most common solid extracranial tumour, appearing during childhood and displaying a differentiated clinical behaviour. Considering the
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20

Kiriyama, Yoshimitsu, Hiroshi Tokumaru, Hisayo Sadamoto, and Hiromi Nochi. "Biological Actions of Bile Acids via Cell Surface Receptors." International Journal of Molecular Sciences 26, no. 11 (2025): 5004. https://doi.org/10.3390/ijms26115004.

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Bile acids (BAs) are synthesized in the liver from cholesterol and are subsequently conjugated with glycine and taurine. In the intestine, bile acids undergo various modifications, such as deconjugation, dehydrogenation, oxidation, and epimerization by the gut microbiota. These bile acids are absorbed in the intestine and transported to the liver as well as the systemic circulation. BAs can activate many types of receptors, including nuclear receptors and cell surface receptors. By activating these receptors, BAs can exert various effects on the metabolic, immune, and nervous systems. Recently
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21

Finbloom, D. S. "Regulation of cell-surface receptors for human interferon-γ on the human histiocytic lymphoma cell line U937". Biochemical Journal 274, № 3 (1991): 775–80. http://dx.doi.org/10.1042/bj2740775.

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Interferon-gamma (IFN gamma) binds to high-affinity receptors on monocytes and is rapidly internalized. This study investigates the ability of the human monocyte-like cell line, U937, to regulate the cell-surface expression of the IFN gamma receptor (IFN gamma R) during endocytosis of ligand. Recombinant IFN gamma was radiolabelled to high specific radioactivity with Bolton-Hunter reagent and used to enumerate IFN gamma R on treated U937 cells. Cells which had internalized IFN gamma for up to 3 h displayed maximal levels of IFN gamma R at all time points tested after all unlabelled IFN gamma h
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22

Mehta, S. R., S. R. Grant, and A. L. Maizel. "Characterization of the cell surface receptors for human B cell growth factor of 12,000 molecular weight." Journal of Immunology 137, no. 7 (1986): 2210–14. http://dx.doi.org/10.4049/jimmunol.137.7.2210.

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Abstract Quiescent normal human B cells have been shown to require an activation step before proliferating in response to B cell growth factor (BCGF) of 12,000 m.w. (12 kd). One effect of cell activation has been the putative acquisition of specific cell surface growth factor receptors. In this report, the existence of such receptors has been confirmed by using purified radioiodinated BCGF-12 kd. BCGF-12 kd receptors on activated B cells have been shown to be distinct form those interacting with IL 2. Scatchard analysis revealed both high affinity receptor sites with an apparent Kd of 28.6 pM
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23

Penberthy, Kristen K., and Kodi S. Ravichandran. "Apoptotic cell recognition receptors and scavenger receptors." Immunological Reviews 269, no. 1 (2015): 44–59. http://dx.doi.org/10.1111/imr.12376.

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24

Moskalev, Alexander V., Boris Yu Gumilevskiy, Vasiliy Ya Apchel, and Vasiliy N. Cygan. "T-cell receptor family, signal transduction, and transcription factors in T-cell immune response." Bulletin of the Russian Military Medical Academy 27, no. 1 (2025): 135–46. https://doi.org/10.17816/brmma636850.

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This study investigated signal transduction in T-lymphocytes, whose cell receptors are categorized into several groups based on their signaling mechanisms and the intracellular biochemical pathways they activate, including modular signaling proteins and adapter molecules that perform scaffolding or catalytic functions. Adapter proteins facilitate signaling complexes by linking various enzymes. Immune receptors, which are composed of integral membrane proteins from the immunoglobulin superfamily, interact with specific tyrosine-containing motifs within transmembrane signaling proteins in their
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25

Hendrickson, Wayne A. "Transduction of biochemical signals across cell membranes." Quarterly Reviews of Biophysics 38, no. 4 (2005): 321–30. http://dx.doi.org/10.1017/s0033583506004136.

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1. Introduction 3212. Tyrosine kinase receptors 3223. Histidine kinase sensors 3254. G-protein coupled receptors 3275. Principles 3286. Acknowledgments 3297. References 330Biological cells need to be responsive to various stimuli, primarily chemical ligands from their environments. Specific receptor molecules embedded in the plasma membrane detect the different biochemical signals that impact the cell, and these receptors are the conduits for transmission of this information to the cell interior for action. There are several classes of signal transduction receptors and many specific receptors
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26

Visintin, I., and J. L. Luborsky. "Comparison of monoclonal luteinizing hormone (LH) receptor antibody and LH binding sites in vibratome sections of rat ovary by immunohistochemistry." Journal of Histochemistry & Cytochemistry 37, no. 11 (1989): 1711–19. http://dx.doi.org/10.1177/37.11.2809177.

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To identify luteinizing hormone (LH) receptors, a monoclonal antibody (MAb) was produced by immunization of Balb/c mice with rat luteal cell membranes. Hybridomas, produced by a method for proteins of low antigenicity, were selected by competition with [125I]-hCG (LH) for luteal membrane binding. Conditions for analysis of LH receptor antibody (IgG2b isotype) binding by immunohistochemistry with an avidin-biotin-peroxidase complex were examined and results compared to localization of bound hCG, to detect receptors. By light microscopy, both bound hCG and the LH receptor antibody were located o
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27

Braulke, T., C. Gartung, A. Hasilik, and K. von Figura. "Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?" Journal of Cell Biology 104, no. 6 (1987): 1735–42. http://dx.doi.org/10.1083/jcb.104.6.1735.

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Mannose 6-phosphate-specific receptors with an apparent molecular mass of 215,000 are present in fibroblasts at the cell surface and in intracellular membranes. The cell surface receptors mediate endocytosis of exogenous lysosomal enzymes and exchange with the intracellular receptors, which function in the sorting of endogenous lysosomal enzymes. In the present study, several methods independent of receptor ligands were designed in order to examine the exchange of receptors under conditions where receptor-ligand complexes do not dissociate (weak bases and monensin) or where receptor-ligand com
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28

Park, Seung-Yoon, and In-San Kim. "Stabilin Receptors: Role as Phosphatidylserine Receptors." Biomolecules 9, no. 8 (2019): 387. http://dx.doi.org/10.3390/biom9080387.

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Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) an
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29

Huang, Hayden, Jeremy Sylvan, Maxine Jonas, et al. "Cell stiffness and receptors: evidence for cytoskeletal subnetworks." American Journal of Physiology-Cell Physiology 288, no. 1 (2005): C72—C80. http://dx.doi.org/10.1152/ajpcell.00056.2004.

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Viscoelastic models of cells often treat cells as homogeneous objects. However, studies have demonstrated that cellular properties are local and can change dramatically on the basis of the location probed. Because membrane receptors are linked in various ways to the intracellular space, with some receptors linking to the cytoskeleton and others diffusing freely without apparent linkages, the cellular physical response to mechanical stresses is expected to depend on the receptor engaged. In this study, we tested the hypothesis that cellular mechanical stiffness as measured via cytoskeletally li
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30

Lu, M. L., R. J. McCarron, and B. S. Jacobson. "Initiation of HeLa cell adhesion to collagen is dependent upon collagen receptor upregulation, segregation to the basal plasma membrane, clustering and binding to the cytoskeleton." Journal of Cell Science 101, no. 4 (1992): 873–83. http://dx.doi.org/10.1242/jcs.101.4.873.

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It was recently reported that HeLa cells have three Arg-Gly-Asp-dependent collagen receptors that do not appear to be in the integrin family of extracellular matrix receptors and bind to either type I or IV collagen or to type I gelatin. It was our goal to determine how these receptors function in HeLa cell-substratum adhesion. We report here that the sequence of events by which the receptors mediate adhesion to collagen or gelatin is: (1) induction of cell attachment by specific collagen receptor-substratum interactions with culture dishes covalently coated with either type I collagen or gela
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31

Turner, AM, LG Bennett, NL Lin, et al. "Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines." Blood 85, no. 8 (1995): 2052–58. http://dx.doi.org/10.1182/blood.v85.8.2052.bloodjournal8582052.

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Stem cell factor (SCF) triggers cell growth by binding to cell surface c-kit receptors. Soluble forms of several cytokine receptors have been described and may play a role in the modulation of cytokine activity in vivo. For these reasons, we investigated whether human hematopoietic cells produce soluble c-kit receptors. The human leukemia cell lines OCIM1 and MO7e display approximately 80,000 and approximately 35,000 high-affinity cell surface c-kit receptors, respectively. Soluble c-kit receptors were detected by enzyme immunoassay in OCIM1 and MO7e culture supernatants. We determined the mol
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32

Ziegler, C. G., J. W. Brown, A. V. Schally, et al. "Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: Antiproliferative effects of peptide analogues." Proceedings of the National Academy of Sciences 106, no. 37 (2009): 15879–84. http://dx.doi.org/10.1073/pnas.0907843106.

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Peptide analogues targeting various neuropeptide receptors have been used effectively in cancer therapy. A hallmark of adrenocortical tumor formation is the aberrant expression of peptide receptors relating to uncontrolled cell proliferation and hormone overproduction. Our microarray results have also demonstrated a differential expression of neuropeptide hormone receptors in tumor subtypes of human pheochromocytoma. In light of these findings, we performed a comprehensive analysis of relevant receptors in both human adrenomedullary and adrenocortical tumors and tested the antiproliferative ef
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33

Farag, Sherif S., Todd A. Fehniger, Loredana Ruggeri, Andrea Velardi, and Michael A. Caligiuri. "Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect." Blood 100, no. 6 (2002): 1935–47. http://dx.doi.org/10.1182/blood-2002-02-0350.

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AbstractNatural killer (NK) cells have held great promise for the immunotherapy of cancer for more than 3 decades. However, to date only modest clinical success has been achieved manipulating the NK cell compartment in patients with malignant disease. Progress in the field of NK cell receptors has revolutionized our concept of how NK cells selectively recognize and lyse tumor and virally infected cells while sparing normal cells. Major families of cell surface receptors that inhibit and activate NK cells to lyse target cells have been characterized, including killer cell immunoglobulinlike rec
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34

DeMaria, Shannon, and John Ngai. "The cell biology of smell." Journal of Cell Biology 191, no. 3 (2010): 443–52. http://dx.doi.org/10.1083/jcb.201008163.

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The olfactory system detects and discriminates myriad chemical structures across a wide range of concentrations. To meet this task, the system utilizes a large family of G protein–coupled receptors—the odorant receptors—which are the chemical sensors underlying the perception of smell. Interestingly, the odorant receptors are also involved in a number of developmental decisions, including the regulation of their own expression and the patterning of the olfactory sensory neurons' synaptic connections in the brain. This review will focus on the diverse roles of the odorant receptor in the functi
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35

Brann, Mark R., Terri Messier, Christine Dorman, and Deborah Lannigan. "Cell-Based Assays for G-Protein-Coupled/Tyrosine Kinase-Coupled Receptors." Journal of Biomolecular Screening 1, no. 1 (1996): 43–45. http://dx.doi.org/10.1177/108705719600100114.

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Using mammalian cells transiently transfected with receptors, we have developed an assay [Receptor Selection and Amplification Technology (R-SAT); patents pending] that links ligand-dependent cellular transformation to induction of 8-galactosidase in a 96-well plate format. Using these procedures, we have performed high throughput functional assays of receptors that mediate signal transduction by a diversity of mechanisms. Examples include the prostanoid, muscarinic, and neurokinin receptor subtypes that signal via the G-proteins Gq and Gi, the JAK/STAT-linked GM-CSF receptor, the tyrosine kin
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36

Biassoni, Roberto, Claudia Cantoni, Daniela Pende, et al. "Human natural killer cell receptors and co-receptors." Immunological Reviews 181, no. 1 (2001): 203–14. http://dx.doi.org/10.1034/j.1600-065x.2001.1810117.x.

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37

Bąbolewska, Edyta, and Ewa Brzezińska-Błaszczyk. "Mast cell inhibitory receptors." Postępy Higieny i Medycyny Doświadczalnej 66 (October 22, 2012): 739–51. http://dx.doi.org/10.5604/17322693.1015039.

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38

MILES, LINDSEY A., STEPHEN B. HAWLEY, and ROBERT J. PARMER. "Chromaffin Cell Plasminogen Receptors." Annals of the New York Academy of Sciences 971, no. 1 (2002): 454–59. http://dx.doi.org/10.1111/j.1749-6632.2002.tb04508.x.

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39

Nemazee, David, and Martin Weigert. "Revising B Cell Receptors." Journal of Experimental Medicine 191, no. 11 (2000): 1813–18. http://dx.doi.org/10.1084/jem.191.11.1813.

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40

Jaffe, Iris Z., and Frédéric Jaisser. "Endothelial Cell Mineralocorticoid Receptors." Hypertension 63, no. 5 (2014): 915–17. http://dx.doi.org/10.1161/hypertensionaha.114.01997.

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41

Degitz, Klaus, and S. Wright Caughman. "T-Cell Antigen Receptors." Dermatologic Clinics 8, no. 4 (1990): 663–72. http://dx.doi.org/10.1016/s0733-8635(18)30453-4.

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42

Gravitz, Lauren. "Shape-Shifting Cell Receptors." American Scientist 108, no. 1 (2020): 6. http://dx.doi.org/10.1511/2020.108.1.6.

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43

Carpentier, J. L. "3 Cell Surface Receptors." Progress in Histochemistry and Cytochemistry 26, no. 1-4 (1992): 77–87. http://dx.doi.org/10.1016/s0079-6336(11)80081-1.

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44

Moretta, Lorenzo, Roberto Biassoni, Cristina Bottino, Maria C. Mingari, and Alessandro Moretta. "Human NK-cell receptors." Immunology Today 21, no. 9 (2000): 420–22. http://dx.doi.org/10.1016/s0167-5699(00)01673-x.

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45

Long, Eric O., and Nicolai Wagtmann. "Natural killer cell receptors." Current Opinion in Immunology 9, no. 3 (1997): 344–50. http://dx.doi.org/10.1016/s0952-7915(97)80080-5.

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46

Yokoyama, Wayne M. "Natural killer cell receptors." Current Opinion in Immunology 10, no. 3 (1998): 298–305. http://dx.doi.org/10.1016/s0952-7915(98)80168-4.

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47

Born, W. "The T-cell receptors." Trends in Genetics 5 (1989): 162–63. http://dx.doi.org/10.1016/0168-9525(89)90063-2.

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48

Dejana, Elisabetta. "Endothelial Cell Adhesive Receptors." Journal of Cardiovascular Pharmacology 21 (1993): S18—S21. http://dx.doi.org/10.1097/00005344-199321001-00004.

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49

Pule, M., H. Finney, and A. Lawson. "Artificial T-cell receptors." Cytotherapy 5, no. 3 (2003): 211–26. http://dx.doi.org/10.1080/14653240310001488.

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50

Bannister, P., and M. S. Losowsky. "Cell Receptors and Ethanol." Alcoholism: Clinical and Experimental Research 10, s1 (1986): 50S—54S. http://dx.doi.org/10.1111/j.1530-0277.1986.tb05180.x.

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