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Journal articles on the topic 'Cell respiration'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Harborne, Jeffrey B. "Higher plant cell respiration." Phytochemistry 25, no. 6 (1986): 1515. http://dx.doi.org/10.1016/s0031-9422(00)81331-x.

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2

Mawson, B. T. "Cyanide-resistant, alternative pathway respiration in guard cell protoplasts of Vicia faba." Canadian Journal of Botany 72, no. 2 (1994): 150–56. http://dx.doi.org/10.1139/b94-020.

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The activity and capacity of cyanide-resistant or alternative pathway respiration was examined in Vicia faba L. guard and mesophyll cell protoplasts maintained either in darkness (dark adapted) or illuminated with blue light. Respiration rates by dark-adapted guard cell protoplasts were unaffected by titrating with salicylhydroxamic acid (0.1–2.0 mM), an inhibitor of alternative pathway respiration, suggesting the lack of activity of this pathway. In combination with 0.1 mM KCN, an inhibitor of cytochrome pathway respiration, salicylhydroxamic acid was effective in inhibiting total respiration

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3

Alfatni, Abrar, Anne-Laure Charles, François Sauer, et al. "Peripheral Blood Mononuclear Cells Mitochondrial Respiration and Superoxide Anion after Heart Transplantation." Journal of Clinical Medicine 11, no. 23 (2022): 7247. http://dx.doi.org/10.3390/jcm11237247.

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Introduction: The mitochondrial function of circulating peripheral blood mononuclear cells (PBMCs) is an interesting new approach to cardiac diseases. Thus, PBMC’s mitochondrial respiration decreases in relation to heart failure severity. However, no data are available on heart-transplanted patients (Htx). Population and Methods: We determined PBMCs mitochondrial respiration by high-resolution respirometry (Oroboros Instruments) and superoxide anion production using electron paramagnetic resonance (Bruker-Biospin) in 20 healthy subjects and 20 matched Htx and investigated clinical, biological,

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4

Black, Clanton C. "Plant Respiration Higher Plant Cell Respiration R. Douce D. A. Day." BioScience 37, no. 10 (1987): 742–43. http://dx.doi.org/10.2307/1310486.

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5

MacDonald, J. R., M. Oellermann, S. Rynbeck, et al. "Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: evidence that mitochondrial dysfunction begins in the subepicardium." American Journal of Physiology-Cell Physiology 300, no. 2 (2011): C246—C255. http://dx.doi.org/10.1152/ajpcell.00294.2010.

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In diabetic cardiomyopathy, ventricular dysfunction occurs in the absence of hypertension or atherosclerosis and is accompanied by altered myocardial substrate utilization and depressed mitochondrial respiration. It is not known if mitochondrial function differs across the left ventricular (LV) wall in diabetes. In the healthy heart, the inner subendocardial region demonstrates higher rates of blood flow, oxygen consumption, and ATP turnover compared with the outer subepicardial region, but published transmural respirometric measurements have not demonstrated differences. We aim to measure mit

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6

Garmash, E. V. "Mitochondrial respiration of the photosynthesizing cell." Russian Journal of Plant Physiology 63, no. 1 (2016): 13–25. http://dx.doi.org/10.1134/s1021443715060072.

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7

SIEDOW, J. N. "Plant Mitochondria: Higher Plant Cell Respiration." Science 230, no. 4723 (1985): 313–14. http://dx.doi.org/10.1126/science.230.4723.313.

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8

Li, Ding, Zhexu Ding, Manjin Gui, Yanmei Hou, and Kui Xie. "Metabolic Enhancement of Glycolysis and Mitochondrial Respiration Are Essential for Neuronal Differentiation." Cellular Reprogramming 22, no. 6 (2020): 291–99. http://dx.doi.org/10.1089/cell.2020.0034.

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9

Lu, Zhenmin, Miguel A. Quiñones, and Eduardo Zeiger. "Temperature dependence of guard cell respiration and stomatal conductance co-segregate in an F2 population of Pima cotton." Functional Plant Biology 27, no. 5 (2000): 457. http://dx.doi.org/10.1071/pp98128.

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In Pima cotton (Gossypium barbadense L.), stomatal conductance shows a strong response to temperature. At high temperature (40˚C), the stomatal conductance of greenhouse- and growth chamber-grown leaves is three and four times higher than that measured at lower temperature (25&ordm;C), respectively. The segregation of stom-atal conductance observed in an F2 population obtained from a cross between a primitive cotton (B368) and a modern Pima line (Pima S-6) increased substantially with temperature in both light and darkness. Furthermore, F2 segregants with high stomatal conductance at high

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10

Ryan, Michael G. "Growth and maintenance respiration in stems of Pinuscontorta and Piceaengelmannii." Canadian Journal of Forest Research 20, no. 1 (1990): 48–57. http://dx.doi.org/10.1139/x90-008.

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Stem maintenance respiration was linearly related to live-cell volume for lodgepole pine (Pinuscontorta var. latifolia Engelm.) from 4 to 36 cm dbh and for Engelmann spruce (Piceaengelmannii Parry) from 0 to 20 cm dbh. Sapwood contained greater than 80% of the total live-cell volume in stems. Bole surface area, commonly used to estimate tree respiration costs, poorly estimated stem maintenance respiration. At 15 °C, maintenance costs for lodgepole pine were 6.6 × 10−5 kg C•(kg C sapwood)−1•d−1. Stem respiration during the growing season, both corrected and uncorrected for maintenance, correlat

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11

E, Bon, Maksimovich N.Ye, and Dremza I.K. "Methodological Approaches to the Study of Mitochondrial Respiration." Journal of Clinical Case Reports and Studies 3, no. 3 (2022): 01–06. http://dx.doi.org/10.31579/2690-8808/108.

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Energy exchange in the cell is associated with mitochondria, which play an important role in vital processes. The Oxidative Phosphorylation System (OxРhoS), localized in the inner mitochondrial membrane, consists of five membrane enzymes. Four of the five protein complexes make up the "respiratory chain" and are involved in the transfer of electrons, which at three points is coupled with the translocation of protons across the inner mitochondrial membrane. The resulting proton gradient is used by the ATP synthase complex (the fifth enzyme complex) to phosphorylate ADP. The methods for studying

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12

Shafiei, Rasoul, Frank Delvigne, and Phillipe Thonart. "Flow-cytometric assessment of damages to Acetobacter senegalensis during freeze-drying process and storage." Acetic Acid Bacteria 2, no. 1s (2013): 10. http://dx.doi.org/10.4081/aab.2013.s1.e10.

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Downstream processes have great influences on bacterial starter production. Different modifications occur to cellular compounds during freeze-drying process and storage of bacterial starters. Consequently, viability and culturability (multiplication capacity) undergo some changes. In this study, the effects of freeze-drying process and storage conditions were examined on cell envelope integrity, respiration and culturability of <em>Acetobacter senegalensis</em>. Freezing of cells protected with mannitol (20% w/w) did not affect cell multiplication and respiration considerably; howe

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13

Asami, Kouichi. "‘A century homework,’: how fertilisation causes elevation of respiration in the sea urchin egg." Zygote 8, S1 (1999): S5—S6. http://dx.doi.org/10.1017/s0967199400130023.

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The lecture given by Dr Yasumasu should be considered from two points of view, namely its significance in the field of developmental biology and his own personal history as a developmental biologist.In 1908 Otto Warburg published a paper entitled ‘Beobachtungen üeber die Oxydationsprozesse im Seeigelei’ (Warburg, 1908). This is one of his earliest works, where he measured respiration of eggs with Winkler's method not with his manometer. This was the first paper describing the fact that the respiration in unfertilised eggs was considerably lower than that in fertilised ones. Many researchers co

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14

Verkhovsky, Michael I., Joel E. Morgan, Anne Puustinen, and Mårten Wikström. "Kinetic trapping of oxygen in cell respiration." Nature 380, no. 6571 (1996): 268–70. http://dx.doi.org/10.1038/380268a0.

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15

Schulz, Hans-Ulrich, Matthias Pross, Frank Meyer, Rainer Matthias, and Walter Halangk. "ACINAR CELL RESPIRATION IN EXPERIMENTAL ACUTE PANCREATITIS." SHOCK 3, no. 3 (1995): 184–88. http://dx.doi.org/10.1097/00024382-199503000-00005.

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16

Mazur, H., B. O. Manko, and V. V. Manko. "Effect of ethanol and cyclosporine A on respiration of isolated rat hepatocytes." Visnyk of Lviv University. Biological series, no. 91 (June 7, 2024): 86–91. http://dx.doi.org/10.30970/vlubs.2024.91.09.

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It is known that ethanol affects the oxidative processes in liver mitochondria, which can be one of the mechanisms of the development of the alcoholic liver disease. A well-known immunosuppressant cyclosporine A is also an inhibitor of mitochondrial permeability transition pore. However, the pharmacological interaction of ethanol and cyclosporin A is not sufficiently studied. The aim of the study was to investigate the effect of ethanol and cyclosporine A on the respiration rate of isolated rat hepatocytes. Five male Wistar rats were used in the study. Hepatocytes were isolated by perfusion w

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17

Pelicano, Hélène, Rui-hua Xu, Min Du, et al. "Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism." Journal of Cell Biology 175, no. 6 (2006): 913–23. http://dx.doi.org/10.1083/jcb.200512100.

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Cancer cells exhibit increased glycolysis for ATP production due, in part, to respiration injury (the Warburg effect). Because ATP generation through glycolysis is less efficient than through mitochondrial respiration, how cancer cells with this metabolic disadvantage can survive the competition with other cells and eventually develop drug resistance is a long-standing paradox. We report that mitochondrial respiration defects lead to activation of the Akt survival pathway through a novel mechanism mediated by NADH. Respiration-deficient cells (ρ-) harboring mitochondrial DNA deletion exhibit d

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18

Govindjee. "Advances in Photosynthesis and Respiration: Focus on Plant Respiration." Photosynthesis Research 85, no. 2 (2005): 255–59. http://dx.doi.org/10.1007/s11120-005-4919-0.

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19

Darenova, Eva, Petr Horáček, Jan Krejza, Radek Pokorný, and Marian Pavelka. "Seasonally varying relationship between stem respiration, increment and carbon allocation of Norway spruce trees." Tree Physiology 40, no. 7 (2020): 943–55. http://dx.doi.org/10.1093/treephys/tpaa039.

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Abstract Stem respiration is an important component of an ecosystem’s carbon budget. Beside environmental factors, it depends highly on tree energy demands for stem growth. Determination of the relationship between stem growth and stem respiration would help to reveal the response of stem respiration to changing climate, which is expected to substantially affect tree growth. Common measurement of stem radial increment does not record all aspects of stem growth processes, especially those connected with cell wall thickening; therefore, the relationship between stem respiration and stem radial i

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20

Ray, S., S. Dutta, J. Halder, and M. Ray. "Inhibition of electron flow through complex I of the mitochondrial respiratory chain of Ehrlich ascites carcinoma cells by methylglyoxal." Biochemical Journal 303, no. 1 (1994): 69–72. http://dx.doi.org/10.1042/bj3030069.

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The effect of methylglyoxal on the oxygen consumption of Ehrlich-ascites-carcinoma (EAC)-cell mitochondria was tested by using different respiratory substrates, electron donors at different segments of the mitochondrial respiratory chain and site-specific inhibitors to identify the specific respiratory complex which might be involved in the inhibitory effect of methylglyoxal on the oxygen consumption by these cells. The results indicate that methylglyoxal strongly inhibits ADP-stimulated alpha-oxo-glutarate and malate plus pyruvate-dependent respiration, whereas, at a much higher concentration

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21

Balbina J Plotkin, Ira M Sigar, Amber Kaminski, and Monika I Konaklieva. "Putative pathways fueling anaerobic mitochondrial respiration." World Journal of Advanced Research and Reviews 14, no. 2 (2022): 603–12. http://dx.doi.org/10.30574/wjarr.2022.14.2.0464.

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Tumor interiors undergo prolonged anoxia; however, the pathways involved have not been identified. Since NO and H2S function in prokaryotic anaerobic respiration, the effect their pathway elements have on HeLa 229 cell viability was measured after 10 days anaerobic incubation. Arginine or xanthine (NO pathway precursors) increased cell viability (13.1- and 4.4-fold, respectively). The H2S pathway precursor, cysteine, also enhanced viability (9.8-fold), as did H2S donor GYY4137, or inhibitor of glutathione synthesis, propargylglycine, (40- and 85-fold, respectively). These results demonstrate t

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22

Strzyz, Paulina. "ER stress boosts respiration." Nature Reviews Molecular Cell Biology 20, no. 8 (2019): 453. http://dx.doi.org/10.1038/s41580-019-0139-x.

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23

Mohell, N., E. Connolly, and J. Nedergaard. "Distinction between mechanisms underlying alpha 1- and beta-adrenergic respiratory stimulation in brown fat cells." American Journal of Physiology-Cell Physiology 253, no. 2 (1987): C301—C308. http://dx.doi.org/10.1152/ajpcell.1987.253.2.c301.

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Experimental conditions are described for selective alpha 1- and beta-adrenergic stimulation of the respiration of brown fat cells. The dual agonist norepinephrine was unsuitable as a selective alpha 1-agonist, since unacceptably high concentrations of propranolol were needed to abolish the beta-response. Phenylephrine at 50 microM, in the presence of 5 microM dl-propranolol, was shown to lead to a maximal, selective alpha 1-stimulation, whereas maximal, selective beta-stimulation was achieved with 1 microM isoproterenol in the presence of 5 microM prazosin. The mitochondrial uncoupler carbony

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24

Balbina, J. Plotkin, M. Sigar Ira, Kaminski Amber, and I. Konaklieva Monika. "Putative pathways fueling anaerobic mitochondrial respiration." World Journal of Advanced Research and Reviews 14, no. 2 (2022): 603–12. https://doi.org/10.5281/zenodo.7299236.

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Tumor interiors undergo prolonged anoxia; however, the pathways involved have not been identified. Since NO and H<sub>2</sub>S function in prokaryotic anaerobic respiration, the effect their pathway elements have on HeLa 229 cell viability was measured after 10 days anaerobic incubation. Arginine or xanthine (NO pathway precursors) increased cell viability (13.1- and 4.4-fold, respectively). The H<sub>2</sub>S pathway precursor, cysteine, also enhanced viability (9.8-fold), as did H<sub>2</sub>S donor GYY4137, or inhibitor of glutathione synthesis, propargylglycine, (40- and 85-fold, respectiv

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25

Komarkova, Eliska, Jan Paca, Eva Klapkova, Marie Stiborova, Carlos R. Soccol, and Miroslav Sobotka. "Physiological changes of Candida tropicalis population degrading phenol in fed batch reactor." Brazilian Archives of Biology and Technology 46, no. 4 (2003): 537–43. http://dx.doi.org/10.1590/s1516-89132003000400007.

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Candida tropicalis can use phenol as the sole carbon and energy source. Experiments regarding phenol degradations from the water phase were carried out. The fermentor was operated as a fed-batch system with oxistat control. Under conditions of nutrient limitation and an excess of oxygen the respiration activity of cells was suppressed and some color metabolites (black-brown) started to be formed. An accumulation of these products inhibited the cell growth under aerobic conditions. Another impact was a decrease of the phenol hydroxylase activity as the key enzyme of the phenol degradation pathw

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26

Owiredu, Shawn, Abhay Ranganathan, David M. Eckmann, et al. "Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals." American Journal of Physiology-Cell Physiology 319, no. 1 (2020): C129—C135. http://dx.doi.org/10.1152/ajpcell.00539.2019.

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The purpose of this study was to evaluate a new pharmacological strategy using a first-generation succinate prodrug, NV118, in peripheral blood mononuclear cells (PBMCs) obtained from subjects with carbon monoxide (CO) poisoning and healthy controls. We obtained human blood cells from subjects with CO poisoning and healthy control subjects. Intact PBMCs from subjects in the CO and Control group were analyzed with high-resolution respirometry measured in pmol O2 per second per 10−6 PBMCs. In addition to obtaining baseline respiration, NV118 (100 μM) was injected, and the same parameters of resp

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27

Zub, Anastasiia, Bohdan V. Manko, Bohdan O. Manko, Volodymyr Manko, and Andriy Babsky. "Uncoupled respiration stability of isolated pancreatic acini as a novel functional test for cell vitality." Studia Biologica 17, no. 3 (2023): 243–52. http://dx.doi.org/10.30970/sbi.1703.735.

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Background. Assessment of cell viability is crucial in cell studies. Testing plasma membrane integrity is a traditional approach of evaluating cell viability. Mitochondrial functional capacity closely correlates with plasma membrane integrity and overall cell health. This study aimed to investigate whether any aspect of mitochondrial adaptive capacity in isolated pancreatic acini is associated with the quality of isolated pancreatic acini preparations, as determined by the dye exclusion method. Materials and Methods. Experiments were carried out on male Wistar rats weighing 250–300 g. A suspe

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28

ORSI, Antonia, Belén BELTRÁN, Emilio CLEMENTI, Katarina HALLÉN, Martin FEELISCH, and Salvador MONCADA. "Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium." Biochemical Journal 346, no. 2 (2000): 407–12. http://dx.doi.org/10.1042/bj3460407.

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Nitric oxide (NO) plays a key role in many physiological and pathophysiological events, including the control of cell respiration. Both reversible and irreversible inhibition of mitochondrial respiration have been reported following the generation of NO by cells. We have exposed the murine macrophage cell line J774 to high concentrations of NO, such as are generated in some pathological conditions, and determined their effect on oxygen consumption. We observed a persistent inhibition of respiration which was due to a redox-dependent, progressive inhibition of complex I activity. No other enzym

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29

Bu, Pengli, Shreya Nagar, Madhura Bhagwat, et al. "DNA damage response activates respiration and thereby enlarges dNTP pools to promote cell survival in budding yeast." Journal of Biological Chemistry 294, no. 25 (2019): 9771–86. http://dx.doi.org/10.1074/jbc.ra118.007266.

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The DNA damage response (DDR) is an evolutionarily conserved process essential for cell survival. Previously, we found that decreased histone expression induces mitochondrial respiration, raising the question whether the DDR also stimulates respiration. Here, using oxygen consumption and ATP assays, RT-qPCR and ChIP-qPCR methods, and dNTP analyses, we show that DDR activation in the budding yeast Saccharomyces cerevisiae, either by genetic manipulation or by growth in the presence of genotoxic chemicals, induces respiration. We observed that this induction is conferred by reduced transcription

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30

Wiley, David J., Paola Catanuto, Flavia Fontanesi, et al. "Bot1p Is Required for Mitochondrial Translation, Respiratory Function, and Normal Cell Morphology in the Fission Yeast Schizosaccharomyces pombe." Eukaryotic Cell 7, no. 4 (2008): 619–29. http://dx.doi.org/10.1128/ec.00048-07.

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ABSTRACT Maintenance of cell morphology is essential for normal cell function. For eukaryotic cells, a growing body of recent evidence highlights a close interdependence between mitochondrial function, the cytoskeleton, and cell cycle control mechanisms; however, the molecular details of this interconnection are still not completely understood. We have identified a novel protein, Bot1p, in the fission yeast Schizosaccharomyces pombe. The bot1 gene is essential for cell viability. bot1Δ mutant cells expressing lower levels of Bot1p display altered cell size and cell morphology and a disrupted a

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31

Antonova, G. F., V. V. Stasova, G. G. Suvorova, and V. A. Oskolkov. "Xylogenesis, Photosynthesis and Respiration in Scots Pine Trees Growing in Eastern Siberia (Russia)." Онтогенез 54, no. 5 (2023): 323–40. http://dx.doi.org/10.31857/s0475145023050038.

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Wood formation (xylogenesis) in trees depends on photosynthesis and respiration. Temperature and precipitation affect photosynthesis and respiration and accordingly growth processes in a tree. We studied xylem and phloem cell formation, cell wall biomass accumulation, photosynthesis productivity, and trunk respiration in Scots pine trees growing in eastern Siberia (Russia) in the years with contrasting summer-weather conditions. The number of cells in the differentiation zones and the morphological parameters of the cells produced by the cambium were determined on samples taken mainly after 10

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32

VanHook, Annalisa M. "Mitochondrial respiration not required." Science Signaling 12, no. 585 (2019): eaay2985. http://dx.doi.org/10.1126/scisignal.aay2985.

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33

Chandel, Navdeep S., G. R. Scott Budinger, Sang H. Choe, and Paul T. Schumacker. "Cellular Respiration during Hypoxia." Journal of Biological Chemistry 272, no. 30 (1997): 18808–16. http://dx.doi.org/10.1074/jbc.272.30.18808.

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34

Pelicano, Hélène, Li Feng, Yan Zhou, et al. "Inhibition of Mitochondrial Respiration." Journal of Biological Chemistry 278, no. 39 (2003): 37832–39. http://dx.doi.org/10.1074/jbc.m301546200.

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35

Matias, Pedro M., Ana V. Coelho, Filipa M. A. Valente, et al. "Sulfate Respiration inDesulfovibrio vulgarisHildenborough." Journal of Biological Chemistry 277, no. 49 (2002): 47907–16. http://dx.doi.org/10.1074/jbc.m207465200.

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36

Daneri, Giovanni, Arantza Iriarte, Virginia M. Garcia, Duncan A. Purdie, and David W. Crawford. "Growth Irradiance as a Factor Controlling the Dark Respiration Rates of Marine Phytoplankton." Journal of the Marine Biological Association of the United Kingdom 72, no. 3 (1992): 723–26. http://dx.doi.org/10.1017/s0025315400059488.

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Respiration rates normalized to chlorophyll a of laboratory cultures of Brachiomonas sp., Gyrodinium aureolum, Synechococcus sp. (clone WH 7803), Pycnococcus provasolii (clone W48–23) and Phaeocystis sp. showed a positive relationship with growth photon flux density (Ig). It is argued that this constitutes an energy conserving strategy of adaptation to conditions of low irradiance. The ratio of respiration to light-saturated rate of photosynthesis (R/Pmax) also showed a decrease with decreasing I. Algal cell size, within the investigated range (0·2 to 1380 pg C cell-1), showed little influence

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37

Merce, Adrian P., Anca M. Bînă, Vlad F. Avram, et al. "Cell-Permeable Succinate Improves Platelet Respiration in Patients Undergoing Cardiopulmonary Bypass: A Pilot Study." Timisoara Medical Journal 2022, no. 2 (2022): 1. http://dx.doi.org/10.35995/tmj20220202.

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Open-heart surgery with cardiopulmonary bypass (CPB) remains the standard approach for complex cardiac pathologies, such as advanced coronary heart disease and severe valvular defects. Platelet dysfunction has been widely reported, with both structural and functional changes being elicited by the CPB circuit. Succinate is a mitochondrial substrate that is metabolized through complex II (CII) but is impermeable to cellular membranes when given exogenously. Cell-permeable succinates are novel prodrugs developed to support mitochondrial electron transport (ET) and prevent energy depletion in vari

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38

Patro, Edward T. "Teaching Aerobic Cell Respiration Using the 5 Es." American Biology Teacher 70, no. 2 (2008): 85–87. http://dx.doi.org/10.1662/0002-7685(2008)70[85:tacrut]2.0.co;2.

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Patro, Edward T. "Teaching Aerobic Cell Respiration Using the 5 Es." American Biology Teacher 70, no. 2 (2008): 85–87. http://dx.doi.org/10.2307/30163209.

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40

Dolenc, D., M. Šentjurc, and G. Serša. "EPR oximetry: Reduction of cell respiration by vinblastine." Pflügers Archiv European Journal of Physiology 431, S6 (1996): R261—R262. http://dx.doi.org/10.1007/bf02346368.

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41

Swerdlow, Russell H., Lezi E., Daniel Aires, and Jianghua Lu. "Glycolysis–respiration relationships in a neuroblastoma cell line." Biochimica et Biophysica Acta (BBA) - General Subjects 1830, no. 4 (2013): 2891–98. http://dx.doi.org/10.1016/j.bbagen.2013.01.002.

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42

Riedel, K., P. Liebs, and R. Renneberg. "An electrochemical method for determination of cell respiration." Journal of Basic Microbiology 25, no. 1 (1985): 51–56. http://dx.doi.org/10.1002/jobm.3620250115.

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43

Podbielkowska, Maria, Alicja Zobel, and Maria Wałęza. "Influence of cyclophosphamide on respiration and membrane permeability of plant cells." Acta Societatis Botanicorum Poloniae 49, no. 4 (2014): 357–61. http://dx.doi.org/10.5586/asbp.1980.031.

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A specific influence of cyclophosphamide, an oncostatic drug of the group of alkylating agents, has been demonstrated on cellular respiration and the permeability of cell membranes. The tested drug under the experimental conditions inhibites cell respiration by about 20-30 per cent as compared with the control. The permeability of the plasmalemma and tonoplast de-creased markedly under the action of cyclophosphamide.

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44

Esteves, A. Raquel, Jane Lu, Mariana Rodova, et al. "Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson’s subject mitochondrial transfer." Journal of Neurochemistry 113, no. 3 (2010): 674–82. http://dx.doi.org/10.1111/j.1471-4159.2010.06631.x.

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45

Europe Finner, G. N., H. S. Tillinghast, S. J. McRobbie, and P. C. Newell. "TMB-8 inhibits respiration and cyclic GMP formation in Dictyostelium discoideum." Journal of Cell Science 79, no. 1 (1985): 151–60. http://dx.doi.org/10.1242/jcs.79.1.151.

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The putative inhibitor of intracellular calcium mobilization, TMB-8 was found to be a powerful inhibitor of respiration in amoebae of Dictyostelium discoideum. Consequently, the previously reported effects of this drug on cyclic GMP formation induced by chemoattractants were reassessed. It was found that TMB-8 abolished both folate and cyclic AMP-mediated accumulation of cyclic GMP in D. discoideum amoebae and that addition of Ca2+ completely restored this response. The Ca2+ chelating agent EGTA did not mimic the effect of TMB-8. The effect on cyclic GMP formation, however, occurred only at a

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46

Lobritz, Michael A., Peter Belenky, Caroline B. M. Porter, et al. "Antibiotic efficacy is linked to bacterial cellular respiration." Proceedings of the National Academy of Sciences 112, no. 27 (2015): 8173–80. http://dx.doi.org/10.1073/pnas.1509743112.

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Bacteriostatic and bactericidal antibiotic treatments result in two fundamentally different phenotypic outcomes—the inhibition of bacterial growth or, alternatively, cell death. Most antibiotics inhibit processes that are major consumers of cellular energy output, suggesting that antibiotic treatment may have important downstream consequences on bacterial metabolism. We hypothesized that the specific metabolic effects of bacteriostatic and bactericidal antibiotics contribute to their overall efficacy. We leveraged the opposing phenotypes of bacteriostatic and bactericidal drugs in combination

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CIVELEK, Vildan N., Jude T. DEENEY, Nicholas J. SHALOSKY та ін. "Regulation of pancreatic β-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP". Biochemical Journal 318, № 2 (1996): 615–21. http://dx.doi.org/10.1042/bj3180615.

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To gain insight into the regulation of pancreatic β-cell mitochondrial metabolism, the direct effects on respiration of different mitochondrial substrates, variations in the ATP/ADP ratio and free Ca2+ were examined using isolated mitochondria and permeabilized clonal pancreatic β-cells (HIT). Respiration from pyruvate was high and not influenced by Ca2+ in State 3 or under various redox states and fixed values of the ATP/ADP ratio; nevertheless, high Ca2+ elevated pyridine nucleotide fluorescence, indicating activation of pyruvate dehydrogenase by Ca2+. Furthermore, in the presence of pyruvat

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Aminzadeh-Gohari, Sepideh, Daniela D. Weber, Luca Catalano, René G. Feichtinger, Barbara Kofler, and Roland Lang. "Targeting Mitochondria in Melanoma." Biomolecules 10, no. 10 (2020): 1395. http://dx.doi.org/10.3390/biom10101395.

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Drastically elevated glycolytic activity is a prominent metabolic feature of cancer cells. Until recently it was thought that tumor cells shift their entire energy production from oxidative phosphorylation (OXPHOS) to glycolysis. However, new evidence indicates that many cancer cells still have functional OXPHOS, despite their increased reliance on glycolysis. Growing pre-clinical and clinical evidence suggests that targeting mitochondrial metabolism has anti-cancer effects. Here, we analyzed mitochondrial respiration and the amount and activity of OXPHOS complexes in four melanoma cell lines

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Nowak, Grazyna, та Diana Bakajsova. "Protein kinase C-α activation promotes recovery of mitochondrial function and cell survival following oxidant injury in renal cells". American Journal of Physiology-Renal Physiology 303, № 4 (2012): F515—F526. http://dx.doi.org/10.1152/ajprenal.00072.2012.

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We demonstrated that nonselective PKC activation promotes mitochondrial function in renal proximal tubular cells (RPTC) following toxicant injury. However, the specific PKC isozyme mediating this effect is unknown. This study investigated the role of PKC-α in the recovery of mitochondrial functions in oxidant-injured RPTC. Wild-type PKC-α (wtPKC-α) and inactive PKC-α mutants were overexpressed in RPTC to selectively increase or block PKC-α activation. Oxidant ( tert-butyl hydroperoxidel; TBHP) exposure activated PKC-α in RPTC but decreased PKC-α levels in mitochondria following treatment. Unco

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Silkin, Yuriy A., Mikhail Yu Silkin, Sergey M. Korotkov, Elizaveta N. Silkina, and Alla Silkina. "Erythrocyte Respiratory Activity of the Mitochondrial Complex of the Black Sea Thornback Ray (Raja clavata L.) under the Influence of Certain Activators and Inhibitors In Vitro." Fishes 7, no. 6 (2022): 376. http://dx.doi.org/10.3390/fishes7060376.

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Global warming implies the risk of a changing oxygen regime in the seas and oceans of our planet. The mitochondrial complex of nuclear erythrocytes of cartilaginous fish, as the energy basis of blood cells, has repeatedly encountered such climatic fluctuations throughout their evolutionary history. In this regard, the features of the adaptive strategy of the erythrocyte mitochondrial complex in the thornback ray (Raja clavata L.) are of interest from the evolutionary and ecological points of view. The rate of oxygen consumption in resuspended (Ht = 25–30%) erythrocytes taken from the Black Sea

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