Academic literature on the topic 'Cell transdifferentiation'

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Journal articles on the topic "Cell transdifferentiation"

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OKADA, T. S. "Transdifferentiation in Animal Cells: Fact or Artifact?. (cell commitment/transdifferentiation/cell type conversion)." Development, Growth and Differentiation 28, no. 3 (1986): 213–21. http://dx.doi.org/10.1111/j.1440-169x.1986.00213.x.

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Zhao, Zhiliang, Mengyao Xu, Meng Wu, Xiaocheng Tian, Cuiping Zhang, and Xiaobing Fu. "Transdifferentiation of Fibroblasts by Defined Factors." Cellular Reprogramming 17, no. 3 (2015): 151–59. http://dx.doi.org/10.1089/cell.2014.0089.

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Maclean, Norman. "Transdifferentiation: Flexibility in cell differentiation." Trends in Biochemical Sciences 17, no. 8 (1992): 322. http://dx.doi.org/10.1016/0968-0004(92)90447-h.

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Mitashov, V. I. "Genetic Mechanisms of Cell Transdifferentiation." Russian Journal of Developmental Biology 36, no. 4 (2005): 240–46. http://dx.doi.org/10.1007/s11174-005-0039-1.

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Lee, Tsong-Hai, Pei-Shan Liu, Su-Jane Wang, Ming-Ming Tsai, Velayuthaprabhu Shanmugam, and Hsi-Lung Hsieh. "Bradykinin, as a Reprogramming Factor, Induces Transdifferentiation of Brain Astrocytes into Neuron-like Cells." Biomedicines 9, no. 8 (2021): 923. http://dx.doi.org/10.3390/biomedicines9080923.

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Kinins are endogenous, biologically active peptides released into the plasma and tissues via the kallikrein-kinin system in several pathophysiological events. Among kinins, bradykinin (BK) is widely distributed in the periphery and brain. Several studies on the neuro-modulatory actions of BK by the B2BK receptor (B2BKR) indicate that this neuropeptide also functions during neural fate determination. Previously, BK has been shown to induce differentiation of nerve-related stem cells into neuron cells, but the response in mature brain astrocytes is unknown. Herein, we used rat brain astrocyte (R
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English, Denis. "Transdifferentiation Wars." Stem Cells and Development 14, no. 6 (2005): 605–7. http://dx.doi.org/10.1089/scd.2005.14.605.

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Eisenberg, Leonard M., and Carol A. Eisenberg. "Stem cell plasticity, cell fusion, and transdifferentiation." Birth Defects Research Part C: Embryo Today: Reviews 69, no. 3 (2003): 209–18. http://dx.doi.org/10.1002/bdrc.10017.

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Luo, Liang, Da-Hai Hu, James Q. Yin, and Ru-Xiang Xu. "Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives." Stem Cells International 2018 (September 13, 2018): 1–14. http://dx.doi.org/10.1155/2018/5630802.

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Neurological diseases can severely compromise both physical and psychological health. Recently, adult mesenchymal stem cell- (MSC-) based cell transplantation has become a potential therapeutic strategy. However, most studies related to the transdifferentiation of MSCs into neural cells have had disappointing outcomes. Better understanding of the mechanisms underlying MSC transdifferentiation is necessary to make adult stem cells more applicable to treating neurological diseases. Several studies have focused on adipose-derived stromal/stem cell (ADSC) transdifferentiation. The purpose of this
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Huang, Shian, Xiulong Zhu, Wenjun Huang, et al. "Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/6147294.

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This study aimed to investigate the effects and mechanisms of quercetin on pulmonary arterial endothelial cell (PAEC) transdifferentiation into smooth muscle-like cells. TGF-β1-induced PAEC transdifferentiation models were applied to evaluate the pharmacological actions of quercetin. PAEC proliferation was detected with CCK8 method and BurdU immunocytochemistry. Meanwhile, the identification and transdifferentiation of PAECs were determined by FVIII immunofluorescence staining andα-SMA protein expression. The related mechanism was elucidated based on the levels of Akt and Erk1/2 signal pathway
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Corbett, James L., and David Tosh. "Conversion of one cell type into another: implications for understanding organ development, pathogenesis of cancer and generating cells for therapy." Biochemical Society Transactions 42, no. 3 (2014): 609–16. http://dx.doi.org/10.1042/bst20140058.

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Metaplasia is the irreversible conversion of one differentiated cell or tissue type into another. Metaplasia usually occurs in tissues that undergo regeneration, and may, in a pathological context, predispose to an increased risk of disease. Studying the conditions leading to the development of metaplasia is therefore of significant clinical interest. In contrast, transdifferentiation (or cellular reprogramming) is a subset of metaplasia that describes the permanent conversion of one differentiated cell type into another, and generally occurs between cells that arise from neighbouring regions
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Dissertations / Theses on the topic "Cell transdifferentiation"

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Cambuli, Francesco. "Comparative analysis of ES cell transdifferentiation to TS-like cells." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648815.

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Yuan, Songyang. "Differentiation and transdifferentiation of adult pancreatic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ30425.pdf.

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Madhavan, Mayur C. "Mechanisms of Transdifferentiation and Regeneration." Miami University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=miami1133554812.

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Fakhry, Maya. "Molecular mechanisms of vascular smooth muscle cell transdifferentiation into osteochondrocyte-like cells." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10246.

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Chez les patients souffrant d'insuffisance rénale chronique, les calcifications vasculaires représentent la première cause de mortalité. Elles résultent de la trans-différenciation des cellules musculaires lisses (CMLs) en cellules de type ostéoblastique et/ou chondrocytaire, en réponse à des cytokines inflammatoires ou à une hyperphosphatémie. Les CMLs forment alors des cristaux par l'activité de la phosphatase alcaline non-spécifique du tissu (TNAP). A la lumière de résultats récents, nous avons émis l'hypothèse que la TNAP module la trans différenciation des CMLs. Nos objectifs étaient donc
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Mojica, Jorge Ricardo. "Commitment and transdifferentiation of adult progenitor cells: The contributing pathways." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27717.

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C2C12 murine progenitors are a model for transdifferentiation. This project investigated signaling events that regulate this process in culture by monitoring specific markers for transdifferentiation (alkaline phosphatase [ALP] and myogenin for the osteoblastic and myoblaststic fates respectively) in the presence of inducers and inhibitors. Antibodies specific for proteins implicated in signaling were used to monitor the differentiation process. BMP-2 addition caused transdifferentiation to the osteoblastic fate except for a small fraction of cells that may represent the so-called MyoD negativ
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Yuan, Yuan. "Small-Molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and \(\beta\)-Cell Transdifferentiation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10637.

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Small molecules are important not only for treating human diseases but also for studying disease-related biological processes. This dissertation focuses on the effects of small molecules on pancreatic ductal adenocarcinoma cells. Here, I describe the discovery of two small-molecule tool compounds and their applications for interrogating the biological processes related to two distinct diseases in the human pancreas. First, BRD4770 was identified as a histone methyltransferase inhibitor through a target-based biochemical approach, and was used as a probe to study the function of methyltransfera
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Barbosa-Sabanero, Karla Y. "Dedifferentiation and transdifferentiation: a study of the RPE cell identity." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1468660645.

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Gsour, Amna. "Differentiation of human cell line towards a pancreatic endocrine lineage." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/differentiation-of-human-cell-line-towards-a-pancreatic-endocrine-lineage(0c2c21fe-724d-449f-804c-02741c89828c).html.

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Islet transplantations have been successful in restoring glucose homeostasis in patients with diabetes; however, the limited number of donor organs limits the success of this treatment. The lineage reprograming of different cell sources to beta cells potentially provides an unlimited supply of insulin-producing cells for regenerative therapy for patients with diabetes. The aim of this study was to investigate the ability to transdifferentiate two cell lines into an endocrine lineage. Insulin production in pancreatic beta cells can be increased using a small molecule, 3,5-disubstituted isoxazol
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Rapino, Francesca 1982. "Induced transdifferentiation of human B-leukemia/lymphoma cell lines and inhibition of leukemogenicity." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/128575.

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B-cell malignancies encompass a wide variety of distinct diseases including Non Hodgkin lymphoma (NHL) and leukemia. Currently, chemotherapy, radiation and anti-CD20 antibody treatment are the mainstays of B-cell lymphoma and leukemia therapy. However, the fact that a large number of patients are eventually not cured justifies the search for novel and more effective therapeutic approaches. Although induction of differentiation has been shown to be effective in several tumors such as acute promyelocytic leukemia, it has not been tested yet in NHL and leukemia. We therefore hypothesized
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Gharibi, Borzo. "Adenosine receptor expression and function during mesenchymal stem cell differentiation and osteoblast transdifferentiation." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54352/.

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The mechanisms involved in osteoblast and adipocyte differentiation from the common progenitor, mesenchymal stem cell (MSC) are not fully understood. The nucleoside, adenosine, exists in all cells and is known to be involved in cell growth, proliferation and apoptosis by interacting with four distinct receptors (Ai, A2A, A2b and A3). The aims of this study was to investigate the expression and function of adenosine receptors in 1) MSCs and as they differentiated into osteoblasts and adipocytes and in 2) mouse 7F2 and human osteoblasts and during their transdifferentiation to adipocytes. Rat MS
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Books on the topic "Cell transdifferentiation"

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Transdifferentiation: Flexibility in cell differentiation. Clarendon Press, 1991.

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Book chapters on the topic "Cell transdifferentiation"

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Opas, M. "Cytomechanics of Transdifferentiation." In Cell Mechanics and Cellular Engineering. Springer New York, 1994. http://dx.doi.org/10.1007/978-1-4613-8425-0_14.

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Eguchi, Goro. "‘Transdifferentiation’ of Vertebrate Cells in Cell Culture." In Ciba Foundation Symposium 40 - Embryogenesis in Mammals. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720226.ch12.

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Adamska, Maja. "Differentiation and Transdifferentiation of Sponge Cells." In Results and Problems in Cell Differentiation. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92486-1_12.

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McDevitt, David S. "Transdifferentiation in Animals A Model for Differentiation Control." In Genomic Adaptability in Somatic Cell Specialization. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-6820-9_7.

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Sanges*, Daniela, Frederic Lluis*, and Maria Pia Cosma. "Cell-Fusion-Mediated Reprogramming: Pluripotency or Transdifferentiation? Implications for Regenerative Medicine." In Advances in Experimental Medicine and Biology. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0763-4_9.

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Meivar-Levy, Irit, Hila Barash, and Sarah Ferber. "Transdifferentiation of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes." In Pancreatic Islet Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45307-1_8.

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Xiao, Xinhua, and Yijing Liu. "Cell Transplantation Therapy for Diabetes Mellitus: From Embryonic Stem Cells to Transdifferentiation of Adult Cells." In Translational Medicine Research. Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-7273-0_21.

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Ries, Christian, and Virginia Egea. "Human Mesenchymal Stem Cell Transdifferentiation to Neural Cells: Role of Tumor Necrosis Factor Alpha." In Stem Cells and Cancer Stem Cells, Volume 8. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4798-2_7.

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Louis, Lithin K., A. Ashwini, Anujith Kumar, and Rajarshi Pal. "Transdifferentiation: A Lineage Instructive Approach Bypassing Roadways of Induced Pluripotent Stem Cell (iPSC)." In Regenerative Medicine: Laboratory to Clinic. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3701-6_8.

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Domínguez-Bendala, Juan. "Transdifferentiation." In Pancreatic Stem Cells. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-132-5_7.

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Conference papers on the topic "Cell transdifferentiation"

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Muthukrishnan, SD, M. Johnson, and H. Kornblum. "29 Radiation promotes transdifferentiation of glioblastoma stem cells into vascular cell types." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.29.

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Gopal, Priyanka, Kevin Rogacki, Craig D. Peacock, and Mohamed E. Abazeed. "Abstract 2897: Dynamic transdifferentiation programs in small cell lung carcinoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2897.

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Gopal, Priyanka, Kevin Rogacki, Craig D. Peacock, and Mohamed E. Abazeed. "Abstract 2897: Dynamic transdifferentiation programs in small cell lung carcinoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2897.

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Takeuchi, Kenneth K., Kathleen E. Delgiorno, Christopher J. Halbrook, and Howard C. Crawford. "Abstract IA13: Acinar cell transdifferentiation sets the stage for early tumor heterogeneity." In Abstracts: AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.panca2014-ia13.

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Shao, Rong, Steve Scully, Ralph Francescone, et al. "Abstract 1024: Mural cell transdifferentiation of glioblastoma stem-like cells drives vasculogenic mimicry in glioblastoma development." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1024.

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Volk-Draper, Lisa, Kelly Hall, Michael Flister, and Sophia Ran. "Abstract 400: A new model for macrophage transdifferentiation into lymphatic endothelial cell progenitors." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-400.

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"The first insights into regulation of cell transdifferentiation during gut regeneration in Eupentacta fraudatrix." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-005.

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Zhou, Beiyun, Yixin Liu, Crystal Marconett, et al. "HDAC3 And GATA-6/p300 Coordinately Regulate Type I Cell-Specific Aquaporin-5 (Aqp5) Gene Expression During Alveolar Epithelial Cell (AEC) Transdifferentiation." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4217.

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Réthi, B., A. Krishnamurthy, J. Ytterberg, et al. "FRI0006 Protein citrullinations by pad enzymes promote dendritic cell transdifferentiation into osteoclast and generate targets for ra-specific antibodies." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5971.

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Togo, Shinsaku, Kumi Nagahama, Xiangde Liu, et al. "Stromal Fibroblasts Associated With Lung Cancer Cells Enhanced Transdifferentiation Into Myofibroblast." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5555.

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Reports on the topic "Cell transdifferentiation"

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Du, Cheng. Transdifferentiation between Luminal- and Basal-Type Cancer Cells. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada601036.

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