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Relevant bibliographies by topics / Cell transdifferentiation / Dissertations / Theses

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Dissertations / Theses on the topic 'Cell transdifferentiation'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Cambuli, Francesco. "Comparative analysis of ES cell transdifferentiation to TS-like cells." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648815.

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2

Yuan, Songyang. "Differentiation and transdifferentiation of adult pancreatic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ30425.pdf.

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3

Madhavan, Mayur C. "Mechanisms of Transdifferentiation and Regeneration." Miami University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=miami1133554812.

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4

Fakhry, Maya. "Molecular mechanisms of vascular smooth muscle cell transdifferentiation into osteochondrocyte-like cells." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10246.

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Chez les patients souffrant d'insuffisance rénale chronique, les calcifications vasculaires représentent la première cause de mortalité. Elles résultent de la trans-différenciation des cellules musculaires lisses (CMLs) en cellules de type ostéoblastique et/ou chondrocytaire, en réponse à des cytokines inflammatoires ou à une hyperphosphatémie. Les CMLs forment alors des cristaux par l'activité de la phosphatase alcaline non-spécifique du tissu (TNAP). A la lumière de résultats récents, nous avons émis l'hypothèse que la TNAP module la trans différenciation des CMLs. Nos objectifs étaient donc

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5

Mojica, Jorge Ricardo. "Commitment and transdifferentiation of adult progenitor cells: The contributing pathways." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27717.

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C2C12 murine progenitors are a model for transdifferentiation. This project investigated signaling events that regulate this process in culture by monitoring specific markers for transdifferentiation (alkaline phosphatase [ALP] and myogenin for the osteoblastic and myoblaststic fates respectively) in the presence of inducers and inhibitors. Antibodies specific for proteins implicated in signaling were used to monitor the differentiation process. BMP-2 addition caused transdifferentiation to the osteoblastic fate except for a small fraction of cells that may represent the so-called MyoD negativ

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6

Yuan, Yuan. "Small-Molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and \(\beta\)-Cell Transdifferentiation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10637.

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Small molecules are important not only for treating human diseases but also for studying disease-related biological processes. This dissertation focuses on the effects of small molecules on pancreatic ductal adenocarcinoma cells. Here, I describe the discovery of two small-molecule tool compounds and their applications for interrogating the biological processes related to two distinct diseases in the human pancreas. First, BRD4770 was identified as a histone methyltransferase inhibitor through a target-based biochemical approach, and was used as a probe to study the function of methyltransfera

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7

Barbosa-Sabanero, Karla Y. "Dedifferentiation and transdifferentiation: a study of the RPE cell identity." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1468660645.

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8

Gsour, Amna. "Differentiation of human cell line towards a pancreatic endocrine lineage." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/differentiation-of-human-cell-line-towards-a-pancreatic-endocrine-lineage(0c2c21fe-724d-449f-804c-02741c89828c).html.

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Islet transplantations have been successful in restoring glucose homeostasis in patients with diabetes; however, the limited number of donor organs limits the success of this treatment. The lineage reprograming of different cell sources to beta cells potentially provides an unlimited supply of insulin-producing cells for regenerative therapy for patients with diabetes. The aim of this study was to investigate the ability to transdifferentiate two cell lines into an endocrine lineage. Insulin production in pancreatic beta cells can be increased using a small molecule, 3,5-disubstituted isoxazol

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9

Rapino, Francesca 1982. "Induced transdifferentiation of human B-leukemia/lymphoma cell lines and inhibition of leukemogenicity." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/128575.

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B-cell malignancies encompass a wide variety of distinct diseases including Non Hodgkin lymphoma (NHL) and leukemia. Currently, chemotherapy, radiation and anti-CD20 antibody treatment are the mainstays of B-cell lymphoma and leukemia therapy. However, the fact that a large number of patients are eventually not cured justifies the search for novel and more effective therapeutic approaches. Although induction of differentiation has been shown to be effective in several tumors such as acute promyelocytic leukemia, it has not been tested yet in NHL and leukemia. We therefore hypothesized

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10

Gharibi, Borzo. "Adenosine receptor expression and function during mesenchymal stem cell differentiation and osteoblast transdifferentiation." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54352/.

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The mechanisms involved in osteoblast and adipocyte differentiation from the common progenitor, mesenchymal stem cell (MSC) are not fully understood. The nucleoside, adenosine, exists in all cells and is known to be involved in cell growth, proliferation and apoptosis by interacting with four distinct receptors (Ai, A2A, A2b and A3). The aims of this study was to investigate the expression and function of adenosine receptors in 1) MSCs and as they differentiated into osteoblasts and adipocytes and in 2) mouse 7F2 and human osteoblasts and during their transdifferentiation to adipocytes. Rat MS

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11

Werner, Mimmi. "Hair cell regeneration in vestibular epithelia : a study in an in vitro model." Doctoral thesis, Umeå universitet, Öron- näs- och halssjukdomar, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124077.

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Background Hair cells (HCs) are the sensory receptors in both the auditory and the vestibular organs of the inner ear. Supporting cells (SCs) are non-sensory cells embracing the HCs. Injuries of the HCs by aging, acoustic trauma or ototoxic drugs (mainly aminoglycosides, e.g. gentamicin) and cisplatin, often cause permanent impairment of hearing and balance. Birds and amphibians can regenerate their auditory and vestibular HCs after injury through proliferation of SCs or direct transdifferentiation of a SC into a HC. For mammals this ability is limited and spontaneous HC regeneration occurs on

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12

Hazrati, Ali. "The role of transforming growth factor-beta (TGF-) in the transdifferentiation of islets of Langerhans to duct-like epithelial structures /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33773.

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The process of islet isolation destroys extracellular matrix and eliminates potentially important inter-cellular relationships. We have previously shown that isolated islets embedded in a type I collagen gel, in the presence of a defined medium, undergo a phenotypic switch to duct-like epithelial structures through a process known as transdifferentiation. The aim of this study was to characterize the specific effectors implicated in islet cell transdifferentiation in order to better understand the factors that confer morphogenetic stability on cells in the isolated islets.<br>We demonstrated c

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13

Imamura, Hirotoshi. "Transdifferentiation of bone marrow-derived endothelial progenitor cells into the smooth muscle cell lineage mediated by tansforming growth factor-β1". Kyoto University, 2010. http://hdl.handle.net/2433/120926.

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Matsunaga, Mami. "Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263555.

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15

Cruz, Raphael Marques de Almeida Rosa da. "Diferenciação neuronal de células-tronco de dente decíduo esfoliado." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-11012017-160059/.

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As células-tronco (CT) são células que apresentam propriedades de auto-renovação, capazes de gerar diferentes tipos celulares e reconstituir diversos tipos de tecidos, por isso têm sido vistas como uma alternativa terapêutica para o tratamento de muitas doenças cujo tratamento convencional não é eficiente. Além disso, por sua plasticidade, as CT podem ser usadas para produzir modelos in vitro para o estudo de doenças, o que tem sido particularmente interessante para doenças que acometem o sistema nervoso. As células-tronco humanas de dente decíduo esfoliado (Stem cell from Human Esfoliated Dec

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Son, Yesde. "Exploring the Plasticity of Cellular Fate Using Defined-Factor Reprogramming." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10309.

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Cellular fate, once established, is usually stable for the lifetime of the cell. However, the mechanisms that restrict the developmental potential of differentiated cells are in principle reversible, as demonstrated by the success of animal cloning from a somatic genome through somatic cell nuclear transfer (SCNT). An increased understanding of the molecular determinants of cell fate has also enabled the reprogramming of cell fate using defined transcription factors; recently, these efforts have culminated in the discovery of four genes that convert somatic cells into induced pluripotent stem

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17

Keuylian, Zela Talar. "The implication of adenylyl cyclase isoform 8 and its regulation by the Notch pathway in vascular smooth muscle cell transdifferentiation and pathological vesel remodeling." Paris 6, 2013. http://www.theses.fr/2013PA066110.

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L’athérosclérose se caractérise par le rétrécissement de la taille de la lumière des vaisseaux artériels, appelé “sténose”, par la formation de plaques d’athérome dans la paroi des artères. L’un des facteurs majeurs qui contribue à la progression de la formation des lésions est le changement phénotypique des cellules musculaires lisses médiales. Ce processus permet leur transition d’un phénotype quiescent/contractile à un phénotype sécrétoire, prolifératif et migratoire. Mes travaux consistaient à élucider une partie des mécanismes qui régule ce changement. Nous avons montré que l’expression d

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18

Taylor, Sean R. "Co-expression of HB-EGF and ADAM 12S displays a brown adipose phenotype in mouse and human cell lines." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1524347780576749.

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19

Mongeon, Kevin. "The Study of Hereditary Spastic Paraplegia-Causing Gene DDHD2 Using Cell Models." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37474.

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Hereditary spastic paraplegia type 54 is a rare autosomal recessive neurological gait disorder characterized by paraplegia, muscle spasticity, and intellectual disability. This length-dependent distal axonopathy is caused by mutations in the DDHD2 gene, which encodes the intracellular phospholipase A1 DDHD2. Little is known about the molecular function of the DDHD2 protein, especially in the context of HSP54. Thus, there is a need to further investigate its molecular functions and investigate the impact of DDHD2 deficiency in disease-relevant cells. Here, lipidomic profiling of dermal fibrobla

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20

Deshors, Pauline. "Transdifférenciation radio-induite des cellules souches de glioblastome en cellules endothéliales." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30127.

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Les Glioblastomes (GBM) sont les tumeurs cérébrales les plus fréquentes chez l'adulte. Ces tumeurs sont de mauvais pronostic malgré un traitement lourd associant chirurgie, chimio- et radio-thérapie. En effet, ces tumeurs récidivent inévitablement. La présence d'une sous-population de cellules ayant des caractères souches appelées cellules souches de glioblastome (CSG) peut en partie expliquer l'agressivité de ces tumeurs et l'échec thérapeutique. D'autre part, les GBM sont caractérisés par une vascularisation abondante et anormale. Il a été montré que les CSG se transdifférenciaient en cellul

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Tolentino, Felipe Thadeu 1983. "Produção e avaliação de vetores retrovirais visando à diferenciação de neurônios olfativos in vitro pela superexpressão de fatores de transcrição definidos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316718.

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Orientador: Fabio Papes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T14:16:00Z (GMT). No. of bitstreams: 1 Tolentino_FelipeThadeu_M.pdf: 9244448 bytes, checksum: deea9f7963e05d8a997d9b5a554f9708 (MD5) Previous issue date: 2014<br>Resumo: O Sistema Sensorial Olfativo de mamíferos é composto por vários subsistemas na cavidade nasal. Dentre estes, destacam-se o sistema olfativo principal e o sistema olfativo acessório ou vomeronasal. O primeiro realiza a detecção geral de odores e parece participar também da detec

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22

Wung, Nelly. "Tissue engineering of the liver." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715264.

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Currently, the only cure for liver failure is orthotopic liver transplantation. However, there are insufficient donor organs available to treat every patient on the transplant list and many die before they are able to receive a liver transplant. The bioartificial liver (BAL) device is a potential extracorporeal treatment strategy utilising hepatocytes or hepatocyte-like cells (HLCs) within a bioreactor to recapitulate normal liver function and therefore ‘bridge’ a patient with liver failure until they receive a transplant. The work in this thesis utilised tissue engineering methods to develop

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23

Cassady, John P. "Transdifferentiation of fibroblasts to neural stem cells." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83634.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>The developmental process is carefully controlled by transcriptional and epigenetic changes that occur as a zygote transforms into an adult organism. This process can be reversed by the overexpression of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogr

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Di, Stefano Bruno 1984. "C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells". Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/283484.

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One of the major goals of current stem cell research is understanding the mechanism of somatic cell reprogramming by Oct4, Sox2, Klf4 and Myc (OSKM) into induced pluripotent stem cells (iPSCs). However, the finding that only a small proportion of the cells become reprogrammed, typically requiring >12 days, has hampered progress towards this goal. C/EBPα is a transcription factor specifically expressed in myelomonocytic cells within the hematopoietic system whose forced expression in B cells efficiently induces transdifferentiation into macrophages. We have now found that an 18-hour pul

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Silva, Thaís Girão da. "Mecanismos moleculares envolvidos no fenótipo endotelial em resposta a estímulos físicos e químicos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-22102018-104726/.

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O endotélio reveste a parede vascular e possui função essencial na manutenção da homeostase. A célula endotelial é capaz de perceber estímulos extracelulares, como fatores químicos e mecânicos, transmitir a informação para dentro da célula e regular sua função e fenótipo. Neste sentido, investigamos os mecanismos moleculares associados as células endoteliais em dois contextos importantes de intervenções vasculares 1) nos stents farmacológicos, onde a rapamicina exerce funções antiproliferativas e pró-trombogênicas, e 2) na revascularização cardíaca por ponte de safena, onde o alto estiramento

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O'Neill, Kathy. "Reprogramming hepatocytes into duct-like cells." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528369.

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Primary hepatocytes maintained in culture progressively down regulate liver-specific genes and lose their characteristic function and morphology. This process, termed dedifferentiation, is a hindrance to in vitro modelling of systems such as xenobiotic metabolism, liver disease and regeneration. However the results presented here demonstrate that dedifferentiated hapatocytes spontaneously induce expression of ductal genes, and therefore represent a useful model of cell reprogramming.

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de, Back Walter, Roland Zimm, and Lutz Brusch. "Transdifferentiation of pancreatic cells by loss of contact-mediated signaling." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127265.

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Background: Replacement of dysfunctional β-cells in the islets of Langerhans by transdifferentiation of pancreatic acinar cells has been proposed as a regenerative therapy for diabetes. Adult acinar cells spontaneously revert to a multipotent state upon tissue dissociation in vitro and can be stimulated to redifferentiate into β-cells. Despite accumulating evidence that contact-mediated signals are involved, the mechanisms regulating acinar-to-islet cell transdifferentiation remain poorly understood. Results: In this study, we propose that the crosstalk between two contact-mediated signaling

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Li, Wan-Chun. "In vitro transdifferentiation of liver into functional pancreatic-like cells." Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425508.

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29

de, Back Walter, Roland Zimm, and Lutz Brusch. "Transdifferentiation of pancreatic cells by loss of contact-mediated signaling." BioMed Central, 2013. https://tud.qucosa.de/id/qucosa%3A27291.

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Background: Replacement of dysfunctional β-cells in the islets of Langerhans by transdifferentiation of pancreatic acinar cells has been proposed as a regenerative therapy for diabetes. Adult acinar cells spontaneously revert to a multipotent state upon tissue dissociation in vitro and can be stimulated to redifferentiate into β-cells. Despite accumulating evidence that contact-mediated signals are involved, the mechanisms regulating acinar-to-islet cell transdifferentiation remain poorly understood. Results: In this study, we propose that the crosstalk between two contact-mediated signaling

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30

Meyer, Lionel. "Contribution des cellules souches de glioblastome à l'hétérogénéité tumorale : aspect thérapeutique et développement d'un système d'expression mosaïque fluorescent." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ109/document.

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Le glioblastome (GBM) est la tumeur cérébrale primaire la plus agressive comportant une sous-population de cellules souches tumorales (CSG). Elles sont capables d’auto-renouvellement, de prolifération, de différenciation en cellules exprimant les marqueurs neuraux et de trans-différenciation en cellules de types vasculaires. Dans ce contexte, j’ai dérivé et caractérisé plusieurs lignées de CSG à partir de biopsies de patients. Puis j’ai évalué l’impact des peptides thérapeutiques transmembranaires développés au laboratoire, visant les plateformes de récepteurs de neuropiline-1 et de plexine-A1

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Prahalad, Priya. "9-cis-retinoic acided mediated endothelial transdifferentiation in breast cancer cells." Connect to Electronic Thesis (CONTENTdm), 2008. http://worldcat.org/oclc/645463979/viewonline.

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32

Al-Adsani, Amani Mustafa. "Transdifferentiation of pancreatic AR42J-B13 cells to hepatocyte and ductal phenotypes." Thesis, University of Bath, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503389.

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33

Dawes, Lucy Jean. "TGFÎ² induced transdifferentiation and matrix contraction of human lens epithelial cells." Thesis, University of East Anglia, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433913.

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34

Martínez, Romero Carles. "Polycomb group proteins Bmi1 and Ring1B are involved in cell plasticity and tumorigenesis of the pancreas." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7190.

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L'adenocarcinoma ductal pancreàtic (PDAC) és un dels càncers més letals. Per tal de millorar el diagnòstic precoç, s'estan investigant les etapes inicials de la formació del càncer, com és el cas de les lesions preneoplàstiques, i es vol desxifrar l'origen cel·lular de la malaltia. Les proteïnes Polycomb constitueixen una família de silenciadors epigenètics que es troben en una varietat de tumors sòlids. La hipòtesi principal és que Polycomb pot estar participant en els processos preneoplàstics del pàncreas i en l'aparició i progressió del tumor. La expressió de Bmi1 i Ring1B fou analitzada du

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Sangan, Caroline Beth. "Reprogramming of hepatic and pancreatic cells." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582549.

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Cell therapy involving treatment of diseases with the body’s own cells would benefit both liver diseases and Type 1 diabetes. Liver diseases are associated with a marked reduction in hepatocytes whilst Type 1 diabetes is characterized by the loss of functional insulin-producing β-cells. Treatment is currently achieved by whole organ liver (or hepatocyte) and islet transplantation methods respectively. However the major limitation to this approach is the shortage of organ donors, thus alternative sources of cells must be found. Potential sources with enormous therapeutic potential are existing

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Simonneau, Lionel. "Etude de l'expression des cristallines et de leurs proprietes aggregatives dans les cultures de cellules epitheliales de cristallin de boeuf et de la neurotine embryonnaire de caille normale ou transformee par des retrovirus aviaires." Paris 7, 1988. http://www.theses.fr/1988PA077154.

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Duran, Jason Mathew. "Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/253042.

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Physiology<br>Ph.D.<br>Rationale: Autologous bone marrow- or cardiac-derived stem cell therapy for heart disease has demonstrated safety and efficacy in clinical trials but has only offered limited functional improvements. Finding the optimal stem cell type best suited for cardiac regeneration remains a key goal toward improving clinical outcomes. Objective: To determine the mechanism by which novel bone-derived stem cells support the injured heart. Methods and Results: Cortical bone stem cells (CBSCs) and cardiac-derived stem cells (CDCs) were isolated from EGFP+ transgenic mice and were show

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Bhavsar, Rital. "Newt Lens Regeneration: Role of Oct-4 in Newt Regenerating Tissue and Proteome Analysis of Regeneration Competent Vs. Regeneration Incompetent Cells." University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1397131576.

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Rako, Zvonimir Andelko [Verfasser]. "miRNA-154 mediates the transdifferentiation of alveolar type II to alveolar type I cells in the mouse model of Bronchopulmonary Dysplasia / Zvonimir Andelko Rako." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1219983101/34.

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Rako, Zvonimir A. [Verfasser]. "miRNA-154 mediates the transdifferentiation of alveolar type II to alveolar type I cells in the mouse model of Bronchopulmonary Dysplasia / Zvonimir Andelko Rako." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1219983101/34.

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Baddour, Joelle. "An Approach to Lens Regeneration in Mice Following Lentectomy and the Implantation of a Biodegradable Hydrogel Encapsulating Iris Pigmented Tissue in Combination with Basic Fibroblast Growth Factor." University of Dayton / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1335916825.

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Santos, Filipa Inês Rodrigues dos. "Towards direct transdifferentiation of adult human cells to the pancreatic B-cell fate." Master's thesis, 2013. http://hdl.handle.net/10400.1/7273.

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Dissertação de mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2013<br>Type 1 Diabetes mellitus (T1DM) is one of the most widespread metabolic disorders with epidemic dimension affecting almost 6% of the world’s population. Autoimmune reaction causes selective destruction of the insulin-producing β-cells within the pancreatic islets, leading to both acute and long-term complications. Daily insulin injections treat but no dot cure diabetes. Any progress in obtaining large number of transplantable insulin producing cells would be a maj

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Medina, Abelardo. "Circulating bone marrow-derived precursor cells modulate the wound healing outcome by cell transdifferentiation." 2009. http://hdl.handle.net/2429/12657.

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Normal wound healing process is a regulated biological response of multiple events whose common aim is to restore the integrity of injured tissues. Fibroblasts exert an important role in this process as target cells that allow either tissue remodeling through the predominant production of proteases (i.e., matrix metalloproteinases) or tissue fibrosis through the over-expression of extracellular matrix (ECM) components such as collagens. However, it remains unclear which factors activate such diversity of fibroblast responses and how this decision making process is made. Currently, there is no

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Yin, Shu-Yi, and 尹書翊. "Use of Combinational Omics Approach for Studying Stimulatory Effects of Phyto-chemicals/-extracts on Dendritic cell immunity and Cell Transdifferentiation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/36421536270565608945.

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博士<br>國立中興大學<br>生物科技學研究所<br>100<br>Various omics approaches have been employed and are still considered as highly desirable and useful tools for herbal medicine research, presumably because conventional phytomedicines often utilized multi-factoral formulations, and such phytochemical mixtures are blieved to interact with multiple molecular targets, resulting in composite (e.g., immunomodulatory) effects. In order to globally and integratively evaluate the effects of specific herbal extracts or phytomedicines, in this study various omics approaches including genomics, proteomics, and the associ

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"Role of NG2 expressing cells in murine terminal phalanx regeneration." Tulane University, 2013.

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Abstract:

Research using the adult mammalian model shows that regeneration in the limb is limited to the distal most portion of the terminal phalanx. Recent studies suggest that the cellular contributions made to the regenerating system are lineage restricted and that the niche bone marrow hematopoietic stem cell population’s contributions are minimal. These studies however, do not address other residing populations within the bone marrow, specifically the mesenchymal and endothelial stem cell populations. One of the residing populations, the reputed pericyte or perivascular cells, possesses the ability

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Ye, Lihua. "The roles of pancreatic hormones in regulating pancreas development and beta cell regeneration." 2015. http://hdl.handle.net/1805/8030.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Diabetes mellitus is a group of related metabolic diseases that share a common pathological mechanism: insufficient insulin signaling. Insulin is a hormone secreted from pancreatic β cells that promotes energy storage and consequently lowers blood glucose. In contrast, the hormone glucagon, released by pancreatic α cells, plays a critical complementary role in metabolic homeostasis by releasing energy stores and increasing blood glucose. Restoration of β cell mass in diabetic patients via β cell regeneration is a conceptually proven

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Coetzee, Magdalena. "Differential effects of arachidonic acid and docosahexaenoic acid on cell biology and osteoprotegerin synthesis in osteoblast-like cells." Thesis, 2005. http://upetd.up.ac.za/thesis/available/etd-03092006-114304.

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Schilling, Tatjana. "Transdifferentiation of Human Mesenchymal Stem Cells." Doctoral thesis, 2007. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-24299.

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With ageing, the loss of bone mass correlates with the expansion of adipose tissue in human bone marrow thus facilitating bone-related diseases like osteopenia and osteoporosis. The molecular mechanisms underlying these events are still largely unknown. Reduced osteogenesis and concurrently enhanced adipogenesis might not only occur due to the impairment of conventional osteogenic differentiation originating from mesenchymal stem cells (MSCs). Additionally, transdifferentiation of (pre-)osteoblasts into adipocytes could contribute to the fatty conversion. Therefore, the aim of the present stud

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Schilling, Tatjana [Verfasser]. "Transdifferentiation of human mesenchymal stem cells / vorgelegt von Tatjana Schilling." 2007. http://d-nb.info/985826525/34.

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Tsai, Hung-Li, and 蔡弘曆. "Extracellular Matrix-Cytokine Guides Transdifferentiation from Mesoderm Stem Cells to Neuroectoderm Stem Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/s3rpj5.

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博士<br>臺北醫學大學<br>醫學科學研究所<br>102<br>Mesenchymal stem cells (MSCs) can differentiate into neural stem cells (NSCs) under specific conditions. Wnt was reported to be crucial during embryonic development and adult tissue homeostasis. Wnts regulate neurogenesis, such as neurite and synapse formation, of the neural stem or progenitor cells. In addition to Wnts, tenascin (Tn) family members, TnC and TnR, have been demonstrated to regulate differentiation and migration, as well as neurite outgrowth and survival in numerous types of neurons and progenitor cells. Thus, we hypothesize that Wnt signaling a

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