Relevant bibliographies by topics / Cellular acceptor

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cellular acceptor'

Author: Grafiati
Published: 3 June 2025
Last updated: 19 July 2025

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Journal articles on the topic "Cellular acceptor"

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Taniguchi, Hiroshi, Katsushi Inoue, and Itsuo Takanami. "One-dimensional bounded cellular acceptor with rotated inputs." Systems and Computers in Japan 18, no. 9 (1987): 52–63. http://dx.doi.org/10.1002/scj.4690180906.

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Ahn, Byung-Zun, and Dai-Eun Sok. "Michael Acceptors as a Tool for Anticancer Drug Design." Current Pharmaceutical Design 2, no. 3 (1996): 247–62. http://dx.doi.org/10.2174/1381612802666220921173242.

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Abstract: Interaction of antitumor drugs with cellular targets involves various types of chemical binding, of which covalent binding is one of important strategies in designing effective anticancer molecules. The anticancer compounds employing covalent binding, structurally diverse, belong to many chemical classes, including quinones, mustards, nitrosourea, alkylsulfonate, pyrrolo[l,4]benzodiazepines, and others. Most of these compounds contain, or acquire by cellular metabolism, electrophilic centers, and some are Michael acceptors in a broader sense. Recent evidences suggest that antineoplas
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Spinelli, Jessica B., Paul C. Rosen, Hans-Georg Sprenger, et al. "Fumarate is a terminal electron acceptor in the mammalian electron transport chain." Science 374, no. 6572 (2021): 1227–37. http://dx.doi.org/10.1126/science.abi7495.

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Reversing the chain The mitochondrial electron transport chain is a major part of cellular metabolism and plays key roles in both cellular respiration and the synthesis of critical metabolites. Typically, electrons flow through the electron transport chain in a specific direction, ending up with oxygen as the terminal electron acceptor. Spinelli et al . characterized an alternative path of electron flow through the transport chain, ending with fumarate as the electron acceptor (see the Perspective by Baksh and Finley). This pathway operates under conditions of limited oxygen availability, and
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Takano, Yuta, Tomohiro Numata, Kazuto Fujishima, et al. "Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates." Chemical Science 7, no. 5 (2016): 3331–37. http://dx.doi.org/10.1039/c5sc04135j.

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MORITA, KENICHI, YASUNORI YAMAMOTO, and KAZUHIRO SUGATA. "TWO-DIMENSIONAL THREE-WAY ARRAY GRAMMARS AND THEIR ACCEPTORS." International Journal of Pattern Recognition and Artificial Intelligence 03, no. 03n04 (1989): 353–76. http://dx.doi.org/10.1142/s0218001489000280.

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Two kinds of three-way isometric array grammars arc proposed as subclasses of an isometric monotonic array grammar. They are a three-way horizontally context-sensitive array grammar (3HCSAG) and a three-way immediately terminating array grammar (3ITAG). In these three-way grammars, patterns of symbols can grow only in the leftward, rightward and downward directions. We show that their generating abilities of rectangular languages are precisely characterized by some kinds of three-way two-dimensional Turing machines or related acceptors. In this paper. the following results are proved. First, 3
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Davidson, W. Sean, Wendi V. Rodrigueza, Sissel Lund-Katz, William J. Johnson, George H. Rothblat, and Michael C. Phillips. "Effects of Acceptor Particle Size on the Efflux of Cellular Free Cholesterol." Journal of Biological Chemistry 270, no. 29 (1995): 17106–13. http://dx.doi.org/10.1074/jbc.270.29.17106.

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Bae, W., and B. E. Rittmann. "Accelerating the rate of cometabolic degradations requiring an intracellular electron source-model and biofilm application." Water Science and Technology 31, no. 1 (1995): 29–39. http://dx.doi.org/10.2166/wst.1995.0008.

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This paper applies our recently acquired knowledge of the large and systematic changes in internal reducing power to controlled changes in the cell's primary electron-donor and -acceptor substrates. The systematic cellular responses of the NADH/NAD ratio is incorporated into kinetic equations for reductive dehalogenation and oxygenation reactions. Results show that the external donor and acceptor concentrations strongly affect the percentage removal of hazardous compounds. The simplest strategy for maximizing the efficiency of reductive dehalogenation is to maintain a saturating concentration
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KARASAWA, Satoshi, Toshio ARAKI, Takeharu NAGAI, Hideaki MIZUNO, and Atsushi MIYAWAKI. "Cyan-emitting and orange-emitting fluorescent proteins as a donor/acceptor pair for fluorescence resonance energy transfer." Biochemical Journal 381, no. 1 (2004): 307–12. http://dx.doi.org/10.1042/bj20040321.

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GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) technology has facilitated the exploration of the spatio-temporal patterns of cellular signalling. While most studies have used cyan- and yellow-emitting FPs (fluorescent proteins) as FRET donors and acceptors respectively, this pair of proteins suffers from problems of pH-sensitivity and bleeding between channels. In the present paper, we demonstrate the use of an alternative additional donor/acceptor pair. We have cloned two genes encoding FPs from stony corals. We isolated a cyan-emitting FP from Acropara sp
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Sankaranarayanan, Sandhya, John F. Oram, Bela F. Asztalos, et al. "Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux." Journal of Lipid Research 50, no. 2 (2008): 275–84. http://dx.doi.org/10.1194/jlr.m800362-jlr200.

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Taniguchi, Hiroshi, Katsushi Inoue, and Itsuo Takanami. "One-Dimensional Bounded Cellular Acceptor with Rotated Inputs. A Relationship between ∧ and ∨ Types." Systems and Computers in Japan 20, no. 3 (1989): 1–12. http://dx.doi.org/10.1002/scj.4690200301.

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Dissertations / Theses on the topic "Cellular acceptor"

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Baum, John Victor. "Transglycosylation catalysed by the #beta#-glucosidase activity present in cellulase derived from Trichoderma reesei ATC 26921." Thesis, University of Huddersfield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323807.

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El, Berjawi Rayane. "Construction and characterizations of new perylenediimide based molecular assemblies derived from nitro or amino bay-substituted derivatives." Thesis, Angers, 2019. http://www.theses.fr/2019ANGE0062.

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Les dérivés de pérylènediimide (PDI) font partie des accepteurs d’électrons les plus performants. Leur squelette rigide liéà un système π aromatique étendu, des propriétés optiques et électroniques remarquables et une bonne stabilité chimique et thermique en font de bons candidats comme matériaux de type-n avec de nombreuses applications, en particulier dans le domaine du photovoltaïque organique. Ce travail étudie la réactivité de dérivés pérylènediimides en position «bay» pour la synthèse et la caractérisation de nouveaux systèmes accepteurs originaux dont certains seront utilisés comme maté
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Avalos, Quiroz Yatzil. "Fabrication and characterization of organic solar cells using non-fullerene acceptors." Electronic Thesis or Diss., Aix-Marseille, 2022. http://theses.univ-amu.fr.lama.univ-amu.fr/220202_AVALOSQUIROZ_685ffnmph265yvr990suxs739q_TH%20(2).pdf.

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Au cours des dernières années, le photovoltaïque organique (OPV) a subi une croissance exponentielle grâce à l'introduction d'accepteurs non fullerène (NFAs), ce qui a permis d'obtenir des efficacités (PCE) supérieurs à 18%. Cette technologie offre des caractéristiques très intéressantes telles qu’un processus en solution, la flexibilité et la semi-transparense. Cependant pour pouvoir être produits à grande échelle, les matériaux et les processus de fabrication doivent répondre à certaines spécifications qui ne sont pas souvent abordées dans le contexte du laboratoire. Les matériaux doivent êt
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Salgues, Bruno. "Synthèse et étude d'azaacènes comme accepteurs non-fullerène pour le photovoltaïque organique." Electronic Thesis or Diss., Aix-Marseille, 2021. http://www.theses.fr/2021AIXM0434.

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Les cellules photovoltaïques organiques sont un sujet de recherche particulièrement actif, tant pour la conception et la fabrication de nouvelles cellules que pour la recherche de nouveaux matériaux semi-conducteurs. En effet, ce type de cellule solaire n'a émergé que tardivement, et leurs progrès en terme d'efficacité ont été fulgurants ces dernières années.Porté par deux équipes de recherche de l'Institut des Sciences Moléculaire de Marseille (iSm2) et du Centre Interdisciplinaire des Nanomatériaux de Marseille (CINaM), notre projet combine leurs compétences en chimie de synthèse, photophysi
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Maffeis, Valentin. "Caractérisation et intégration de nouveaux systèmes donneur-accepteur dans des cellules photovoltaïques." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS376/document.

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Ce travail de thèse porte sur l’étudephoto-physique de chromophores donneur-π-accepteur utilisés dans les cellules solaires àcolorant. Après photo-excitation, ces moléculessubissent des processus de transfert de chargeintramoléculaire (ICT), de solvatation etd’injection de charges qui se déroulent dans ledomaine temporel de la picoseconde. Or touterelaxation énergétique de l’état excité diminue lacinétique de l’injection de charges.Des mesures de spectroscopie stationnaire et defluorescence résolue en temps (de la femto- à lananoseconde) ont permis de résoudre ladynamique de relaxation de ces
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Szymanski, Robin. "Vers l’industrialisation des cellules solaires organiques ternaires." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0298.

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L’énergie solaire photovoltaïque organique (OPV) est une technologie émergente exempte de matériaux rares et à faibles coûts énergétiques de production. Ces modules, composés de plusieurs couches minces empilées, peuvent être souples, semi-transparents et de différentes formes et couleurs, permettant de les intégrer dans le paysage urbain ou aux objets du quotidien. A l’échelle laboratoire, les rendements de conversion énergétique reportés en OPV n’ont cessé de croitre d’année en année, grâce en particulier à l’émergence de nouvelles couches actives, classiquement composées de deux semi-conduc
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Buffet, Noémie. "ROPYRENEQUINONES vers des cristaux liquides colonnaires fortement absorbants, de type accepteur pour cellules photovoltaïques." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2008. http://tel.archives-ouvertes.fr/tel-00585321.

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Au cours de cette thèse, j'ai mis au point et validé une voie de synthèse inédite donnant accès à une nouvelle famille de chromophores oligo-péri-naphtyléniques. Notre approche repose sur le couplage de deux briques facilement synthétisables (l'une centrale, l'autre terminale), puis sur une réaction de cyclodéshydrogénation multiple en milieu fortement basique. Aisément fonctionnalisés ensuite par estérification à leurs extrémités, ces colorants présentent un comportement cristallin liquide. Nous avons ainsi réussi à élaborer des cristaux liquides colonnaires absorbant fortement les grandes lo
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Ottone, Chiara. "Nouveaux copolymères donneur-accepteur : préparation, caractérisation physico-chimique et application des cellules photovoltaïques organiques." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00864002.

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Ce travail de thèse concerne l'élaboration de nouveaux copolymères à faible bande interdite de type " push-pull ", constitués par une unité donneuse d'électrons (push) et une unité acceptrice d'électrons (pull) en modulant les relations structures-propriétés par stratégie de synthèse. Des copolymères constitués par des unités acceptrices d'électrons (dérivées du benzothiadiazole ou du thienopyrrolodione) et donneuses d'électrons (3,6-carbazole, 2,7-carbazole, dialkoxybezodithiophène) ont été obtenus par différentes méthodes de couplage carbone carbone (C-C). Des études physico-chimiques par de
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Rousseau, Theodulf. "Elaboration et caractérisation de cellules solaires organiques à base de nouvelles classes de matériaux actifs." Angers, 2011. http://tel.archives-ouvertes.fr/tel-00984367.

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Ce travail porte sur l'élaboration et la caractérisation de cellules solaires organiques à base de nouvelles classes de matériaux donneurs dérivés de petites molécules solubles. Une première phase de ce travail a été consacrée à l'étude des cellules de type hétérojonction volumique à base de poly(3-hexylthiophène) et d'un dérivé soluble du fullerène C60, le PCBM. Le nombre considérable de travaux déjà publiés sur ces dispositifs en ont fait un système modèle particulièrement approprié à l'étude des différents paramètres expérimentaux impliqués dans la fabrication de ce type de cellules et à le
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Sorin, Marie. "Polymères donneur et accepteur d’électrons : synthèse et utilisation comme couche active de cellules solaires organiques." Angers, 2014. https://tel.archives-ouvertes.fr/tel-01084912.

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L'objectif des travaux présentés est la synthèse de nouveaux copolymères donneur (D) et accepteur (A) d'électrons pour les cellules solaires organiques. La méthode de synthèse choisie pour accéder à de tels copolymères est la polymérisation radicalaire contrôlée par transfert de chaîne réversible par addition-fragmentation (RAFT : Reversible Addition-Fragmentation chain Transfer). Cette méthode est particulièrement bien adaptée pour contrôler la polymérisation d'une grande gamme de monomères fonctionnels donneur et accepteur d’électrons. Dans un premier temps, des monomères fonctionnels donneu
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Books on the topic "Cellular acceptor"

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Monaco, Claudia, and Esther Lutgens. Atherosclerosis—a short history. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0010.

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The pathogenesis of human atherosclerotic lesions has long been debated and is still evolving nowadays. First conceptualized as chronically evolving degenerative disease initiating in the mother’s womb, then increasingly accepted as a dynamic process causing severe acute complications that jeopardize the blood flow to the heart. Evolution of the hypothesis mirrored the progress of cellular and molecular biology, leading to progressive broadening of the understanding of cell types and molecules involved in atherogenesis. This chapter describes the current histopathological view on the pathogene
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Kirchman, David L. The nitrogen cycle. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0012.

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Nitrogen is required for the biosynthesis of many cellular components and can take on many oxidation states, ranging from −3 to +5. Consequently, nitrogen compounds can act as either electron donors (chemolithotrophy) or electron acceptors (anaerobic respiration). The nitrogen cycle starts with nitrogen fixation, the reduction of nitrogen gas to ammonium. Nitrogen fixation is carried out only by prokaryotes, mainly some cyanobacteria and heterotrophic bacteria. The ammonium resulting from nitrogen fixation is quickly used by many organisms for biosynthesis, being preferred over nitrate as a ni
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Book chapters on the topic "Cellular acceptor"

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Brady, R. C., F. R. Cabral, M. J. Schibler, and J. R. Dedman. "Cellular Localization of Calmodulin and Calmodulin-Acceptor Proteins." In Calcium and Cell Physiology. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70070-5_7.

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Kaji, Hideko, and Akira Kaji. "Correlated Measurement of Endogenous ATE1 Activity on Native Acceptor Proteins in Tissues and Cultured Cells to Detect Cellular Aging." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2935-1_6.

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Kaji, Hideko, and Akira Kaji. "Correlated Measurement of Endogenous ATE1 Activity on Native Acceptor Proteins in Tissues and Cultured Cells to Detect Cellular Aging." In Methods in Molecular Biology. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2942-0_6.

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Fielding, Christopher J. "Cellular Cholesterol Transport–Microdomains, Molecular Acceptors and Mechanisms." In Cellular Lipid Metabolism. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00300-4_12.

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Ehsani, Sepehr. "New Horizons in Studying the Cellular Mechanisms of Alzheimer’s Disease." In Future of Business and Finance. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-99838-7_4.

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AbstractFollowing an analysis of the state of investigations and clinical outcomes in the Alzheimer’s research field, I argue that the widely accepted ‘amyloid cascade’ mechanistic explanation of Alzheimer’s disease appears to be fundamentally incomplete. In this context, I propose that a framework termed ‘principled mechanism’ (PM) can help remedy this problem. First, using a series of five ‘tests’, PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria and hints at various ways of making the mechanistic explanation more ‘complete’. I will demonstrate these steps using the amyloid explanation, highlighting its missing or problematic mechanistic elements. Second, PM makes an appeal for the discovery and application of ‘biological principles’ that approximate ceteris paribus generalisations or laws and are operative at the level of a biological cell. Although thermodynamic, evolutionary, ecological and other laws or principles from chemistry and the broader life sciences could inform them, biological principles should be considered ontologically unique. These principles could augment different facets of the mechanistic explanation but also allow further independent nomological explanation of the phenomenon. Whilst this overall strategy can be complementary to certain ‘new mechanist’ approaches, an important distinction of the PM framework is its equal attention to the explanatory utility of biological principles. Lastly, I detail two hypothetical biological principles and show how they could each inform and improve the potentially incomplete mechanistic aspects of the amyloid explanation and how they could provide independent explanations for the cellular features associated with Alzheimer’s disease.
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Vives, Joaquim, and Judit Amposta. "Risk Management." In Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64492-5_18.

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AbstractWe live in a world of uncertainty. Moving forward in this context would be much easier if we could manage to identify, analyse, mitigate, and ultimately accept the most relevant threats, with a deep understanding of the actual significance of such risk(s). Remarkably, this strategy can be applied to any field of interest, from daily life to economics or medicine. Indeed, current quality standards in cellular therapy have already incorporated risk-based management in their guidelines. In this chapter, we present the concept of risk management as part of a quality management program and discuss by whom, why, how, and when this approach should be applied in order to benefit the production and use of safe and effective cell-based therapies in general and hematopoietic stem cell transplantation in particular.
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Charley, Carole, Raquel Espada Martín, Ivana Ferrero, Aleksandra Babic, and Iris Bargalló Arraut. "JACIE and Quality Management in HSCT: Implications for Nursing." In The European Blood and Marrow Transplantation Textbook for Nurses. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23394-4_1.

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AbstractLaboratory medicine, along with the airline industry, has a long history of utilising quality management systems. It took until 1999 for the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and the European Group for Blood and Marrow Transplantation (EBMT), known as JACIE, to be established as an accreditation system in the field of haematopoietic stem cell transplantation (HSCT). The aim was to create a standardised system of accreditation to be officially recognised across Europe, and it was based on the accreditation standards established by the US-based Foundation for the Accreditation of Cellular Therapy (FACT).Since the concept of JACIE was originally launched, many European centres have applied for initial accreditation with other centres gaining reaccreditation for the second, third or fourth time. Transplant units, outside of Europe, have accepted the importance of the JACIE Standards, with units in South Africa, Singapore and Saudi Arabia also gaining accreditation.There is evidence that both donor and patient care have improved within the accredited centres (Passweg et al., Bone Marrow Transplant 47:906–923; 2012: Demiriz IS, Tekgunduz E, Altuntas F (2012) What is the most appropriate source for hematopoietic stem cell transplantation?).Peripheral Stem Cell/Bone Marrow/Cord Blood Bone Marrow Res. (2012):Article ID 834040 (online)). However, there is a lack of published evidence demonstrating that this improvement directly results from better nursing care. Therefore, the authors conducted a survey of nursing members of the European Blood and Marrow Transplantation Nurses Group (EBMT (NG)) to identify how nurses working in the area of HSCT felt that JACIE impacted in the care they delivered and the general implications of JACIE for nurses.
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Buechter, Douglas D., and George L. Kenyon. "Inhibitors of Non-Protein Kinases." In Pre-Equilibrium Nuclear Reactions. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198517344.003.0005.

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Abstract Small molecule (non-protein) kinases are ubiquitous enzymes that catalyse the transfer of a phosphoryl group, usually from a nucleoside triphosphate donor (e.g. ATP), to a non-protein acceptor molecule. A few kinases are able to utilize pyrophosphate as the phosphoryl donor (e.g. pyrophosphate dependent phosphofructokinase (Reeves et al. 1974)). Non-protein kinases are key enzymes in numerous critical cellular processes. These include the generation of ‘high-energy phosphate ‘ compounds in glycolysis, cellular storage of such compounds, salvage, and de nova synthesis of nucleotides/ nucleosides for nucleic acid synthesis and phospholipid biosynthesis. Inhibitors of non-protein kinases are of importance in mechanistic and enzymological investigations and in the elucidation of their physiological roles. Because these enzymes catalyse critical biochemical reactions, cellular growth and metabolism are often highly dependent upon their activity. As a result, many of these enzymes are attractive targets for anticancer and antiviral agents. Of particular importance is the design of inhibitors that are selective either for certain isozymes of one organism (e.g. fetal versus adult isozymes) or for enzymes from different organisms (e.g. viral versus host enzymes). The design of such inhibitors is facilitated by an understanding of the mechanism and structure of the enzyme at the molecular level. Thus investigations of the three-dimensional structure, kinetics, chemical mechanism, and active site residues of kinases are of considerable importance in modern drug design.
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Atkins, Peter, George Ratcliffe, Mark Wormald, and Julio de Paula. "Proton transfer equilibria." In Physical Chemistry for the Life Sciences. Oxford University Press, 2023. http://dx.doi.org/10.1093/hesc/9780198830108.003.0021.

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This chapter is concerned with the transfer of protons between molecules. This is an enormously important cellular process and plays a central role in maintaining the appropriate pH, a measure of hydrogen ion concentration, in the various compartments of cells. The chapter first discusses Brønsted–Lowry theory of acids and bases, which states that an acid is a proton donor, and that a base is a proton acceptor. Next the chapter turns to the protonation and deprotonation of molecules, which are key steps in many biochemical reactions. Hereafter, this chapter turns to polyprotic acids, which is a molecular compound that can donate more than one proton. The chapter concludes with a case study on the fractional composition of a solution of lysine.
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"Carbon-based Radicals in C–C Bond Formations in Natural Products." In Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery. The Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/bk9781788010764-00456.

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Molecular oxygen, O2, has a limited role in primary metabolism, albeit a key one as the terminal electron acceptor in mitochondrial respiratory chains. By contrast, oxygenases are interspersed everywhere in the biosynthetic pathways to all the major classes of secondary metabolites. Because O2 is a ground state triplet molecule it is kinetically stable in the presence of organic metabolites, including cellular metabolites. Reductive activation occurs by one-electron paths, mediated either by flavin-dependent enzymes or iron-based enzymes. The iron-based oxygenases carry out homolytic cleavage of substrate C–H bonds, generate carbon-centered radicals, and can lead not only to oxygenation products but to a variety of radical-based rearrangements in product scaffolds, as in morphine, staurosporine, rebeccamycin, penicillin, and cephalosporin biosynthesis.
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Conference papers on the topic "Cellular acceptor"

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Barshinger, James, Mark Feydo, and Steve Strachan. "Development of a Non-intrusive, Wireless, Corrosion Monitoring Device." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-13553.

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Abstract Non-intrusive, ultrasound based, corrosion/erosion monitoring systems are becoming more commonly used and accepted as a method to improve data integrity and increase productivity for Oil & Gas asset inspections – especially with underground, insulated, offshore, and other hard-to-access thickness monitoring locations (TMLs). Example applications where installed sensor technologies have been deployed successfully include crude overhead lines, sour water service, offshore risers for sand monitoring, and midstream buried pipelines. Many additional applications of these systems are an
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Impedovo, S., and G. Saracino. "A New Type Of Cellular Turing Acceptor." In 1986 International Symposium/Innsbruck, edited by John F. Gilmore. SPIE, 1987. http://dx.doi.org/10.1117/12.938513.

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Tsurkas, Andrew, and Gang Bao. "Molecular Beacons for Sensitive Gene Detection in Living Cells." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-42959.

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Real-time imaging of gene expression in living cells has the potential to significantly impact clinical and laboratory studies of cancer, including cancer diagnosis and analysis. Molecular beacons (MBs) provide a simple and promising tool for the detection of target mRNA as tumor markers due to their high signal-to-background ratio, and their improved specificity in detecting point mutations. However, the harsh intracellular environment does limit the sensitivity of MB-based gene detection. Specifically, MBs bound to target mRNAs cannot be distinguished from those degraded by nucleases, or ope
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Guan, Yingxue, Aili Zhang, and Lisa X. Xu. "Theoretical Study of Cellular Uptake of QD Nanoparticles." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53361.

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Cellular uptake kinetics of nanoparticles is one of the key issues determining the design and application of the particles. It is widely accepted that the nanoparticles getting into the cells mainly by endocytosis[1], a process which is found to be inhibited distinctly when temperature is below 4 °C. In fact, some nanoparticles could enter cells at lower temperatures or when the endocytosis was blocked[2–4]. Models describing the intrusion of the nanoparticles into cells only take the endocytosis process into consideration5. Meanwhile, other than the factors as concentration, size, electrical
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Penninger, Charles L., Neal M. Patel, and Andrés Tovar. "A Novel HCA Framework for Simulating the Cellular Mechanisms of Bone Remodeling." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70613.

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Each year, bone metabolic diseases affect millions of people of all ages, genders, and races. Common diseases such as osteopenia and osteoporosis result from the disruption of the bone remodeling process and can place an individual at a serious fracture risk. Bone remodeling is the complex process by which old bone is replaced with new tissue. This process occurs continuously in the body and is carried out by bone cells that are regulated by numerous metabolic and mechanical factors. The remodeling process provides for various functions such as adaptation to mechanical loading, damage repair,
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Penninger, Charles L., Andrés Tovar, Glen L. Niebur, and John E. Renaud. "High Fidelity Computational Model of Bone Remodeling Cellular Mechanisms." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19464.

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One of the most intriguing aspects of bone is its ability to grow, repair damage, adapt to mechanical loads, and maintain mineral homeostasis [1]. It is generally accepted that bone adaptation occurs in response to the mechanical demands of our daily activities; moreover, strain and microdamage have been implicated as potential stimuli that regulate bone remodeling [2]. Computational models have been used to simulate remodeling in an attempt to better understand the metabolic activities which possess the key information of how this process is carried out [3]. At present, the connection between
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Tsourkas, Andrew, and Gang Bao. "Real-Time Observations of the Behavior of Cells Under Controlled Pressure and Shear Loads." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0404.

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Abstract The effect of mechanical loading on cells has aroused a great deal of interest in recent years. It is now widely accepted that mechanical loading is critical for both cell form and function. Although shearing of cells through fluid flow and tensile testing of cells have been widely practiced, there is still a lack of experiments focusing on the effects of controlled pressure and shear loads on cell behavior. The presence of compressive and shear deformations can be seen in a variety of cells ranging from chrondocytes during walking to cardiac myocytes during the cardiac cycle. The aim
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Takai, Erica, Clark T. Hung, Aurea Tucay, et al. "Design of a Microfluidic System for 3D Culture of Osteocytes In Vitro." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33229.

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Bone adapts to its mechanical environment so that its form follows function, a mechanism known as Wolff’s law, or bone adaptation. Although the basic concepts of Wolff’s law have been generally accepted, the regulatory signals and the underlying cellular and molecular pathways, which mediate this adaptive process, are unknown. Failure of normal bone adaptation plays a significant role in the etiology of metabolic bone diseases such as osteoporosis and osteopetrosis, bone loss in space flight and failure of total joint replacements. During the past three decades, there have been extensive in vi
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Penninger, Charles L., Ryan K. Roeder, Glen L. Niebur, and John E. Renaud. "Investigation of Osteoclast Resorption Mechanisms in a Hybrid Cellular Automaton Model of Bone Remodeling." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176171.

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Bone is a living tissue which is continually adapting to its biological environment via continuous formation and resorption. It is generally accepted that bone remodeling occurs in response to daily mechanical loading. The remodeling process enables various functions, such as damage repair, adaptation to mechanical loads, and mineral homeostasis [1]. The cells that are responsible for the bone remodeling process are the bone resorbing osteoclasts and the bone forming osteoblasts. These cells closely coordinate their actions in a basic multicellular unit to renew “packets” of bone.
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Chakraborty, Amlan, V. R. Jala, H. Bodduluri, M. Keith Sharp, and R. Eric Berson. "Effects of Directional Oscillatory Shear Index on Endothelial Cell Proliferation and Morphology." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19626.

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The effects of hemodynamic forces on cellular responses have been studied for the last three decades. Wall shear stresses (WSS) are commonly accepted as an important factor affecting anchored cells subjected to fluid flow [1, 2]. Parallel plate flow chambers and cone and plate apparatuses, which are commonly used to generate controlled shear, are limited in that only one experimental condition can be explored at a time. On the other hand, orbital shakers can be used to investigate several cases simultaneously since many culture dishes can fit on its platform. A remaining challenge, however, is
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Reports on the topic "Cellular acceptor"

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Brosh, Arieh, Gordon Carstens, Kristen Johnson, et al. Enhancing Sustainability of Cattle Production Systems through Discovery of Biomarkers for Feed Efficiency. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7592644.bard.

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Feed inputs represent the largest variable cost of producing meat and milk from ruminant animals. Thus, strategies that improve the efficiency of feed utilization are needed to improve the global competitiveness of Israeli and U.S. cattle industries, and mitigate their environmental impact through reductions in nutrient excretions and greenhouse gas emissions. Implementation of innovative technologies that will enhance genetic merit for feed efficiency is arguably one of the most cost-effective strategies to meet future demands for animal-protein foods in an environmentally sustainable manner.
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Funkenstein, Bruria, and Cunming Duan. GH-IGF Axis in Sparus aurata: Possible Applications to Genetic Selection. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580665.bard.

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Many factors affect growth rate in fish: environmental, nutritional, genetics and endogenous (physiological) factors. Endogenous control of growth is very complex and many hormone systems are involved. Nevertheless, it is well accepted that growth hormone (GH) plays a major role in stimulating somatic growth. Although it is now clear that most, if not all, components of the GH-IGF axis exist in fish, we are still far from understanding how fish grow. In our project we used as the experimental system a marine fish, the gilthead sea bream (Sparus aurata), which inhabits lagoons along the Mediter
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