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Journal articles on the topic 'Cellular acceptor'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Taniguchi, Hiroshi, Katsushi Inoue, and Itsuo Takanami. "One-dimensional bounded cellular acceptor with rotated inputs." Systems and Computers in Japan 18, no. 9 (1987): 52–63. http://dx.doi.org/10.1002/scj.4690180906.

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2

Ahn, Byung-Zun, and Dai-Eun Sok. "Michael Acceptors as a Tool for Anticancer Drug Design." Current Pharmaceutical Design 2, no. 3 (1996): 247–62. http://dx.doi.org/10.2174/1381612802666220921173242.

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Abstract: Interaction of antitumor drugs with cellular targets involves various types of chemical binding, of which covalent binding is one of important strategies in designing effective anticancer molecules. The anticancer compounds employing covalent binding, structurally diverse, belong to many chemical classes, including quinones, mustards, nitrosourea, alkylsulfonate, pyrrolo[l,4]benzodiazepines, and others. Most of these compounds contain, or acquire by cellular metabolism, electrophilic centers, and some are Michael acceptors in a broader sense. Recent evidences suggest that antineoplas

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3

Spinelli, Jessica B., Paul C. Rosen, Hans-Georg Sprenger, et al. "Fumarate is a terminal electron acceptor in the mammalian electron transport chain." Science 374, no. 6572 (2021): 1227–37. http://dx.doi.org/10.1126/science.abi7495.

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Reversing the chain The mitochondrial electron transport chain is a major part of cellular metabolism and plays key roles in both cellular respiration and the synthesis of critical metabolites. Typically, electrons flow through the electron transport chain in a specific direction, ending up with oxygen as the terminal electron acceptor. Spinelli et al . characterized an alternative path of electron flow through the transport chain, ending with fumarate as the electron acceptor (see the Perspective by Baksh and Finley). This pathway operates under conditions of limited oxygen availability, and

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4

Takano, Yuta, Tomohiro Numata, Kazuto Fujishima, et al. "Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates." Chemical Science 7, no. 5 (2016): 3331–37. http://dx.doi.org/10.1039/c5sc04135j.

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5

MORITA, KENICHI, YASUNORI YAMAMOTO, and KAZUHIRO SUGATA. "TWO-DIMENSIONAL THREE-WAY ARRAY GRAMMARS AND THEIR ACCEPTORS." International Journal of Pattern Recognition and Artificial Intelligence 03, no. 03n04 (1989): 353–76. http://dx.doi.org/10.1142/s0218001489000280.

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Two kinds of three-way isometric array grammars arc proposed as subclasses of an isometric monotonic array grammar. They are a three-way horizontally context-sensitive array grammar (3HCSAG) and a three-way immediately terminating array grammar (3ITAG). In these three-way grammars, patterns of symbols can grow only in the leftward, rightward and downward directions. We show that their generating abilities of rectangular languages are precisely characterized by some kinds of three-way two-dimensional Turing machines or related acceptors. In this paper. the following results are proved. First, 3

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Davidson, W. Sean, Wendi V. Rodrigueza, Sissel Lund-Katz, William J. Johnson, George H. Rothblat, and Michael C. Phillips. "Effects of Acceptor Particle Size on the Efflux of Cellular Free Cholesterol." Journal of Biological Chemistry 270, no. 29 (1995): 17106–13. http://dx.doi.org/10.1074/jbc.270.29.17106.

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7

Bae, W., and B. E. Rittmann. "Accelerating the rate of cometabolic degradations requiring an intracellular electron source-model and biofilm application." Water Science and Technology 31, no. 1 (1995): 29–39. http://dx.doi.org/10.2166/wst.1995.0008.

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This paper applies our recently acquired knowledge of the large and systematic changes in internal reducing power to controlled changes in the cell's primary electron-donor and -acceptor substrates. The systematic cellular responses of the NADH/NAD ratio is incorporated into kinetic equations for reductive dehalogenation and oxygenation reactions. Results show that the external donor and acceptor concentrations strongly affect the percentage removal of hazardous compounds. The simplest strategy for maximizing the efficiency of reductive dehalogenation is to maintain a saturating concentration

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8

KARASAWA, Satoshi, Toshio ARAKI, Takeharu NAGAI, Hideaki MIZUNO, and Atsushi MIYAWAKI. "Cyan-emitting and orange-emitting fluorescent proteins as a donor/acceptor pair for fluorescence resonance energy transfer." Biochemical Journal 381, no. 1 (2004): 307–12. http://dx.doi.org/10.1042/bj20040321.

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GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) technology has facilitated the exploration of the spatio-temporal patterns of cellular signalling. While most studies have used cyan- and yellow-emitting FPs (fluorescent proteins) as FRET donors and acceptors respectively, this pair of proteins suffers from problems of pH-sensitivity and bleeding between channels. In the present paper, we demonstrate the use of an alternative additional donor/acceptor pair. We have cloned two genes encoding FPs from stony corals. We isolated a cyan-emitting FP from Acropara sp

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9

Sankaranarayanan, Sandhya, John F. Oram, Bela F. Asztalos, et al. "Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux." Journal of Lipid Research 50, no. 2 (2008): 275–84. http://dx.doi.org/10.1194/jlr.m800362-jlr200.

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10

Taniguchi, Hiroshi, Katsushi Inoue, and Itsuo Takanami. "One-Dimensional Bounded Cellular Acceptor with Rotated Inputs. A Relationship between ∧ and ∨ Types." Systems and Computers in Japan 20, no. 3 (1989): 1–12. http://dx.doi.org/10.1002/scj.4690200301.

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11

Evans, David T., Karl C. Tillman, and Ronald C. Desrosiers. "Envelope Glycoprotein Cytoplasmic Domains from Diverse Lentiviruses Interact with the Prenylated Rab Acceptor." Journal of Virology 76, no. 1 (2002): 327–37. http://dx.doi.org/10.1128/jvi.76.1.327-337.2002.

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ABSTRACT Lentivirus envelope glycoproteins have unusually long cytoplasmic domains compared to those of other retroviruses. To identify cellular binding partners of the simian immunodeficiency virus (SIV) envelope transmembrane protein (gp41) cytoplasmic domain (CD), we performed a yeast two-hybrid screen of a phytohemagglutinin-activated human T-cell cDNA library with the SIV gp41 CD. The majority of positive clones (50 of 54) encoded the prenylated Rab acceptor (PRA1). PRA1 is a 21-kDa protein associated with Golgi membranes that binds to prenylated Rab proteins in their GTP-bound state. Whi

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12

Müller, Günter A. "The Transformation Experiment of Frederick Griffith II: Inclusion of Cellular Heredity for the Creation of Novel Microorganisms." Bioengineering 12, no. 5 (2025): 532. https://doi.org/10.3390/bioengineering12050532.

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So far, synthetic biology approaches for the construction of artificial microorganisms have fostered the transformation of acceptor cells with genomes from donor cells. However, this strategy seems to be limited to closely related bacterial species only, due to the need for a “fit” between donor and acceptor proteomes and structures. “Fitting” of cellular regulation of metabolite fluxes and turnover between donor and acceptor cells, i.e. cybernetic heredity, may be even more difficult to achieve. The bacterial transformation experiment design 1.0, as introduced by Frederick Griffith almost one

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13

Boruah, Bhargavi M., Renuka Kadirvelraj, Lin Liu та ін. "Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases". Journal of Biological Chemistry 295, № 50 (2020): 17027–45. http://dx.doi.org/10.1074/jbc.ra120.014625.

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Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins. Additional modification of the glycan core by α-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an α-1,6-fucosyltransferase (FUT8). The importance of core fucosylation can be seen in the complex pathological phenotypes of FUT8 null mice, which display defects in cellular signaling, development, and subsequent neonatal lethality. Elevated core fucosylation has also been identified in several h

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14

Taniguchi, Hiroshi, Katsushi Inoue, and Itsuo Takanami. "Hierarchical properties of the Îº -neighborhood template A-type 2-dimensional bounded cellular acceptor." Systems and Computers in Japan 18, no. 5 (1987): 79–90. http://dx.doi.org/10.1002/scj.4690180509.

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15

Deneke, S. M., and B. L. Fanburg. "Regulation of cellular glutathione." American Journal of Physiology-Lung Cellular and Molecular Physiology 257, no. 4 (1989): L163—L173. http://dx.doi.org/10.1152/ajplung.1989.257.4.l163.

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In addition to its participation in a variety of other biochemical reactions, glutathione (GSH) is a major antioxidant. It is regularly generated intracellularly from its oxidized form by glutathione reductase activity that is coupled with a series of interrelated reactions. Synthesis of GSH also takes place intracellularly by a two-step reaction, the first of which is catalyzed by rate-limiting gamma-glutamylcysteine synthetase activity. Intracellular substrates for GSH are provided both by direct amino acid transport and by a gamma-glutamyl transpeptidase reaction that salvages circulating G

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16

Zuris, John A., Syed S. Ali, Howard Yeh, et al. "NADPH Inhibits [2Fe-2S] Cluster Protein Transfer from Diabetes Drug Target MitoNEET to an Apo-acceptor Protein." Journal of Biological Chemistry 287, no. 15 (2012): 11649–55. http://dx.doi.org/10.1074/jbc.m111.319731.

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MitoNEET (mNT) is the founding member of the recently discovered CDGSH family of [2Fe-2S] proteins capable of [2Fe-2S] cluster transfer to apo-acceptor proteins. It is a target of the thiazolidinedione (TZD) class of anti-diabetes drugs whose binding modulate both electron transfer and cluster transfer properties. The [2Fe-2S] cluster in mNT is destabilized upon binding of NADPH, which leads to loss of the [2Fe-2S] cluster to the solution environment. Because mNT is capable of transferring [2Fe-2S] clusters to apo-acceptor proteins, we sought to determine whether NADPH binding also affects clu

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17

Centonze, Victoria E., Xiao H. Liang, Elizabeth A. Casanova, Beth Levine, and Brian Herman. "FRET: A Spectral Ruler for Interacting Molecules Involved in Apoptosis." Microscopy and Microanalysis 6, S2 (2000): 830–31. http://dx.doi.org/10.1017/s1431927600036643.

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Fluorescence Resonance Energy Transfer (FRET) is a process by which a fluorophore (the donor) in the excited state transfers its energy to a neighboring fluorophore (the acceptor) non-radiatively through dipole-dipole interactions. Since the efficiency of energy transfer varies as the inverse of the sixth power of the distance separating the donor and acceptor chromophores, for FRET to occur the distance between the two molecules cannot exceed 10 to 100 angstroms (1 to l0nm). The combination of FRET and optical microscopy allows examination and quantitation of dynamic molecular interactions be

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18

Lee, Miriam, Christian P. Sommerhoff, Arnold von Eckardstein, Frank Zettl, Hans Fritz, and Petri T. Kovanen. "Mast Cell Tryptase Degrades HDL and Blocks Its Function as an Acceptor of Cellular Cholesterol." Arteriosclerosis, Thrombosis, and Vascular Biology 22, no. 12 (2002): 2086–91. http://dx.doi.org/10.1161/01.atv.0000041405.07367.b5.

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19

Sakamoto, Makoto, Makoto Nagatomo, Tuo Zhang, et al. "Hierarchy Based on Configuration-Reader about k-Neighborhood Template A-Type Three-Dimensional Bounded Cellular Acceptor." Journal of Robotics, Networking and Artificial Life 1, no. 1 (2014): 80. http://dx.doi.org/10.2991/jrnal.2014.1.1.15.

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20

Sakamoto, Makoto, Makoto Nagatomo, Tuo Zhang, et al. "Hierarchy Based on Neighborhood Template about k-Neighborhood Template A-Type Three-Dimensional Bounded Cellular Acceptor." Journal of Robotics, Networking and Artificial Life 1, no. 1 (2014): 85. http://dx.doi.org/10.2991/jrnal.2014.1.1.16.

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21

de la Llera-Moya, M., Bo Jian, J. B. Swaney, and G. H. Rothblat. "4.P.333 Quantitation of bi-directional flux using serum as an acceptor of cellular cholesterol." Atherosclerosis 134, no. 1-2 (1997): 366. http://dx.doi.org/10.1016/s0021-9150(97)89860-7.

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22

Moynagh, PN, LA O'Neill, and D. C. Williams. "Modulation of the peripheral-type benzodiazepene acceptor by IL1 and PMA." Neurochemistry International 21 (January 1992): C16. http://dx.doi.org/10.1016/0197-0186(92)92093-j.

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23

Bowles, D. "A multigene family of glycosyltransferases in a model plant, Arabidopsis thaliana." Biochemical Society Transactions 30, no. 2 (2002): 301–6. http://dx.doi.org/10.1042/bst0300301.

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Glycosyltransferases transfer sugars from NDP-sugar donors to acceptors. The multigene family of transferases described in this paper typically transfer glucose from UDP-glucose to low-molecular-mass acceptors in the cytosol of plant cells. There are 107 sequences in the genome of Arabidopsis thaliana that contain a consensus, suggesting they belong to this Group 1 multigene family. The family has been analysed phylogenetically, and a functional genomics approach has been applied to explore the relatedness of sequence similarity to catalytic specificity and stereoselectivity. Enzymes belonging

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24

Mardon, H. J., and G. Sebastio. "Regulation of alternative splicing in the IIICS region of human fibronectin pre-mRNA encoding cell binding sites CS1 and CS5." Journal of Cell Science 103, no. 2 (1992): 423–33. http://dx.doi.org/10.1242/jcs.103.2.423.

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The cell binding sites CS1 and CS5 in the IIICS region of human fibronectin (FN) mediate the adhesion of specific cell types by interacting with the integrin alpha 4 beta 1. IIICS pre-mRNA is alternatively spliced via the use of three alternative splice acceptor sites and one alternative splice donor site. These alternative splicing pathways can potentially give rise to variant FN molecules which are CS1+,CS5+; CS1+,CS5-; CS1-,CS5+ or CS1-,CS5-. Here we show that selection of the acceptor site which incorporates mRNA encoding CS1 and CS5 is more frequent in foetal tissues compared to adult liv

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25

de Graef, Mark R., Svetlana Alexeeva, Jacky L. Snoep, and M. Joost Teixeira de Mattos. "The Steady-State Internal Redox State (NADH/NAD) Reflects the External Redox State and Is Correlated with Catabolic Adaptation in Escherichia coli." Journal of Bacteriology 181, no. 8 (1999): 2351–57. http://dx.doi.org/10.1128/jb.181.8.2351-2357.1999.

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ABSTRACT Escherichia coli MC4100 was grown in anaerobic glucose-limited chemostat cultures, either in the presence of an electron acceptor (fumarate, nitrate, or oxygen) or fully fermentatively. The steady-state NADH/NAD ratio depended on the nature of the electron acceptor. Anaerobically, the ratio was highest, and it decreased progressively with increasing midpoint potential of the electron acceptor. Similarly, decreasing the dissolved oxygen tension resulted in an increased NADH/NAD ratio. As pyruvate catabolism is a major switch point between fermentative and respiratory behavior, the flux

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26

Hallak, Marta E., H. S. Barra, and R. Caputto. "Posttranslational Incorporation of [14C]Arginine into Rat Brain Proteins. Acceptor Changes During Development." Journal of Neurochemistry 44, no. 3 (1985): 665–69. http://dx.doi.org/10.1111/j.1471-4159.1985.tb12865.x.

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27

Londino, James D., Dexter L. Gulick, Travis B. Lear, et al. "Post-translational modification of the interferon-gamma receptor alters its stability and signaling." Biochemical Journal 474, no. 20 (2017): 3543–57. http://dx.doi.org/10.1042/bcj20170548.

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The IFN gamma receptor 1 (IFNGR1) binds IFN-γ and activates gene transcription pathways crucial for controlling bacterial and viral infections. Although decreases in IFNGR1 surface levels have been demonstrated to inhibit IFN-γ signaling, little is known regarding the molecular mechanisms controlling receptor stability. Here, we show in epithelial and monocytic cell lines that IFNGR1 displays K48 polyubiquitination, is proteasomally degraded, and harbors three ubiquitin acceptor sites at K277, K279, and K285. Inhibition of glycogen synthase kinase 3 beta (GSK3β) destabilized IFNGR1 while overe

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28

Hansen, Mads, and Ebba Nexø. "The interation of human transcobalamin isopeptides in cerebrospinal fluid and plasma with cobalamin and the cellular acceptor." Biochimica et Biophysica Acta (BBA) - General Subjects 926, no. 3 (1987): 359–64. http://dx.doi.org/10.1016/0304-4165(87)90222-4.

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29

Fatima, Munazza, and Naseem Abbas. "Expanding Horizons in Advancements of FRET Biosensing Technologies." Biosensors 15, no. 7 (2025): 452. https://doi.org/10.3390/bios15070452.

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Förster resonance energy transfer (FRET)-based biosensors are versatile tools for obtaining insights into various biological processes. Their working principles are based on nonradiative energy transfer from donor to acceptor fluorophores. This energy transfer is responsible for a change in fluorescence intensity, which provides a basis for the detection of biomolecules. Advantageous features of FRET biosensors include their high sensitivity and specificity. Recently, there have been notable developments to extend the usage of FRET biosensors for diverse applications. In this review, we briefl

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30

Embí BS, Abrahám A. "AGING AND CELLULAR MAGNETIC PROFILES DOCUMENTATION IN HAIR FOLLICLES CYCLES UTILIZING A NOVEL TABLETOP MAGNETIC PROFILES TECHNIQUE." International Journal of Research -GRANTHAALAYAH 8, no. 3 (2020): 245–56. http://dx.doi.org/10.29121/granthaalayah.v8.i3.2020.150.

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Background: Recently, a tabletop optical microscopy technique was introduced to display living tissue magnetic profiles. The purpose of this manuscript is to introduce via the aforementioned technique in vitro experiments showing the effect of aging on tissue biophysical changes and documentation of cross species magnetic profiles. The term “metabolism” entails electron transfers involving movement of electrons from donor to acceptor, magnetic profiles are theorized to be a reflection of metabolic levels. Methods: The magnetic profiles technique calls for the completion of a blood smear

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31

Abrahám, A. Embí BS MBA. "AGING AND CELLULAR MAGNETIC PROFILES DOCUMENTATION IN HAIR FOLLICLES CYCLES UTILIZING A NOVEL TABLETOP MAGNETIC PROFILES TECHNIQUE." International Journal of Research - Granthaalayah 8, no. 3 (2020): 245–56. https://doi.org/10.5281/zenodo.3734310.

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Background: Recently, a tabletop optical microscopy technique was introduced to display living tissue magnetic profiles. The purpose of this manuscript is to introduce via the aforementioned technique in vitro experiments showing the effect of aging on tissue biophysical changes and documentation of cross species magnetic profiles. The term “metabolism” entails electron transfers involving movement of electrons from donor to acceptor, magnetic profiles are theorized to be a reflection of metabolic levels. Methods: The magnetic profiles technique calls for the completion of a blood

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32

Blázquez, Ana-Belén, and Juan-Carlos Saiz. "Potential for Protein Kinase Pharmacological Regulation in Flaviviridae Infections." International Journal of Molecular Sciences 21, no. 24 (2020): 9524. http://dx.doi.org/10.3390/ijms21249524.

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Protein kinases (PKs) are enzymes that catalyze the transfer of the terminal phosphate group from ATP to a protein acceptor, mainly to serine, threonine, and tyrosine residues. PK catalyzed phosphorylation is critical to the regulation of cellular signaling pathways that affect crucial cell processes, such as growth, differentiation, and metabolism. PKs represent attractive targets for drugs against a wide spectrum of diseases, including viral infections. Two different approaches are being applied in the search for antivirals: compounds directed against viral targets (direct-acting antivirals,

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33

Hand, D., P. J. Bungay, B. M. Elliott, and M. Griffin. "Activation of transglutaminase at calcium levels consistent with a role for this enzyme as a calcium receptor protein." Bioscience Reports 5, no. 12 (1985): 1079–86. http://dx.doi.org/10.1007/bf01119629.

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The sensitivity of tissue transglutaminase to activation by Ca2+ and other cellular factors was investigated using the enzyme purified from rat liver. The inclusion of Mg2+ in the assay system appeared to reduce the Ca2+-requirement of the enzyme when native N,N′-dimethylcasein was used as the protein acceptor substrate. However, when this protein was dephosphorylated, the Ca2+-requirement was unaffected by Mg2+. In addition, using this modified assay, a Km for Ca2+ was calculated to be in the range of 3–4 μM, at least an order of magnitude lower than that obtained with native acceptor substra

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34

del Solar, Virginia, Rohitesh Gupta, Yusen Zhou, Gabrielle Pawlowski, Khushi L. Matta, and Sriram Neelamegham. "Robustness in glycosylation systems: effect of modified monosaccharides, acceptor decoys and azido sugars on cellular nucleotide-sugar levels and pattern of N-linked glycosylation." Molecular Omics 16, no. 4 (2020): 377–86. http://dx.doi.org/10.1039/d0mo00023j.

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Chemical perturbation studies reveal robustness in glycosylation systems, based on comparison of LC-MS/MS quantification of cellular nucleotide-sugar levels with the observed N-linked glycan patterns.

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35

Merker, Marilyn P., Robert D. Bongard, Nicholas J. Kettenhofen, Yoshiyuki Okamoto, and Christopher A. Dawson. "Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 282, no. 1 (2002): L36—L43. http://dx.doi.org/10.1152/ajplung.00283.2001.

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Pulmonary arterial endothelial cells possess transplasma membrane electron transport (TPMET) systems that transfer intracellular reducing equivalents to extracellular electron acceptors. As one aspect of determining cellular mechanisms involved in one such TPMET system in pulmonary arterial endothelial cells in culture, glycolysis was inhibited by treatment with iodoacetate (IOA) or by replacing the glucose in the cell medium with 2-deoxy-d-glucose (2-DG). TPMET activity was measured as the rate of reduction of the extracellular electron acceptor polymer toluidine blue O polyacrylamide. Intrac

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36

Schotte, Alain, William Rostène, and Pierre M. Laduron. "Different Subcellular Localization of Neurotensin-Receptor and Neurotensin-Acceptor Sites in the Rat Brain Dopaminergic System." Journal of Neurochemistry 50, no. 4 (1988): 1026–31. http://dx.doi.org/10.1111/j.1471-4159.1988.tb10568.x.

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37

Abeywickrama, Chathura S., Enya Huang, Wenhui Yan та ін. "Exploring Imaging Applications of a Red-Emitting π-Acceptor (π-A) Pyrene-Benzothiazolium Dye". Biosensors 14, № 12 (2024): 612. https://doi.org/10.3390/bios14120612.

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Bright biocompatible fluorescent imaging dyes with red to near-infrared (NIR) emissions are ideal candidates for fluorescence microscopy applications. Pyrene–benzothiazolium hemicyanine dyes are a new class of lysosome-specific probes reported on recently. In this work, we conduct a detailed implementation study for a pyrene–benzothiazolium derivative, BTP, to explore its potential imaging applications in fluorescence microscopy. The optical properties of BTP are studied in intracellular environments through advanced fluorescence microscopy techniques, with BTP exhibiting a noticeable shift to

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38

Hernández-Fernández, Eugenio, Ana Sofia Ortega-Villarreal, Ma Concepción García-López, et al. "Synthesis and characterization of benzotriazolyl acrylonitrile analogs-based donor-acceptor molecules: Optical properties, in vitro cytotoxicity, and cellular imaging." Dyes and Pigments 189 (May 2021): 109251. http://dx.doi.org/10.1016/j.dyepig.2021.109251.

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39

Guo, Chaorui, Inga Sileikaite, Michael J. Davies, and Clare L. Hawkins. "Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages." Antioxidants 9, no. 12 (2020): 1255. http://dx.doi.org/10.3390/antiox9121255.

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Myeloperoxidase (MPO) is involved in the development of many chronic inflammatory diseases, in addition to its key role in innate immune defenses. This is attributed to the excessive production of hypochlorous acid (HOCl) by MPO at inflammatory sites, which causes tissue damage. This has sparked wide interest in the development of therapeutic approaches to prevent HOCl-induced cellular damage including supplementation with thiocyanate (SCN−) as an alternative substrate for MPO. In this study, we used an enzymatic system composed of glucose oxidase (GO), glucose, and MPO in the absence and pres

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40

Krishnamurthi, Srinivasan, Stefan Spring, Pinnaka Anil Kumar, Shanmugam Mayilraj, Hans-Peter Klenk, and Korpole Suresh. "Desulfotomaculum defluvii sp. nov., a sulfate-reducing bacterium isolated from the subsurface environment of a landfill." International Journal of Systematic and Evolutionary Microbiology 63, Pt_6 (2013): 2290–95. http://dx.doi.org/10.1099/ijs.0.047662-0.

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A novel sulfate-reducing, strictly anaerobic and endospore-forming bacterium, designated strain A5LFS102T, was isolated from a subsurface landfill sample. The strain was characterized using a polyphasic approach. Optimal growth was observed at 37 °C and pH 7.5 with sulfate as an electron acceptor. Sulfite and thiosulfate were utilized as electron acceptors. The respiratory isoprenoid quinone was menaquinone MK-7. 16S rRNA gene sequence analysis assigned strain A5LFS102T to the genus Desulfotomaculum . Both 16S rRNA and dissimilatory sulfate reductase (dsr) genes were compared with those of rep

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Thomas, P. D., and M. J. Poznansky. "Cholesterol transfer between lipid vesicles. Effect of phospholipids and gangliosides." Biochemical Journal 251, no. 1 (1988): 55–61. http://dx.doi.org/10.1042/bj2510055.

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The effect of lipid composition on the rate of cholesterol movement between cellular membranes is investigated using lipid vesicles. The separation of donor and acceptor vesicles required for rate measurement is achieved by differential centrifugation so that the lipid effect can be quantified in the absence of a charged lipid generally used for ion-exchange-based separation. The rate of cholesterol transfer from small unilamellar vesicles (SUVs) containing 50 mol% cholesterol to a common large unilamellar vesicle (LUV) acceptor containing 20 mol% cholesterol decreases with increasing mol% of

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Sehr, Peter, Michael Pawlita, and Joe Lewis. "Evaluation of Different Glutathione S-Transferase–Tagged Protein Captures for Screening E6/E6AP Interaction Inhibitors Using AlphaScreen®." Journal of Biomolecular Screening 12, no. 4 (2007): 560–67. http://dx.doi.org/10.1177/1087057107301246.

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Human papillomavirus (HPV) infection is responsible for the development of cervical cancer and its premalignant lesions in women. The virus-encoded oncogene E6 is a promising target for an anti-HPV drug therapy. The authors describe the development of a homogenous screening assay for inhibitors of the E6 interaction with its cellular target, the E6-associated protein (E6AP), based on AlphaScreen® technology. The E6 protein was expressed and purified as glutathione S-transferase (GST) fusion protein, and the binding to a biotinylated E6AP peptide was monitored using GST-detecting Acceptor beads

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Moe, A. J., D. R. Farmer, D. M. Nelson, and C. H. Smith. "Pentose phosphate pathway in cellular trophoblasts from full-term human placentas." American Journal of Physiology-Cell Physiology 261, no. 6 (1991): C1042—C1047. http://dx.doi.org/10.1152/ajpcell.1991.261.6.c1042.

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Glucose metabolism was investigated in cellular trophoblasts isolated from full-term human placentas. The specific yields of 14CO2 from D-[1-14C]glucose and D-[6-14C]glucose were used to determine glucose metabolism via the pentose cycle for cells freshly isolated or cells grown in culture for 1 and 3 days. Cells were mononucleated on day 1 but fused to form multinucleated syncytiotrophoblasts by day 3. The principal product of glucose metabolism under all conditions was lactate, accounting for approximately three-fourths of recovered 14C in products. Pentose cycle activity contributed 0.57 +/

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J Hashim, Maha, and Jeffrey R Fry. "Evaluation of a Direct Cellular Assay for NQO1 in the Presence of Phytochemicals." Biomedical and Pharmacology Journal 15, no. 3 (2022): 1415–20. http://dx.doi.org/10.13005/bpj/2478.

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NAD(P)H:quinone oxidoreductase NQO1 is a phase ll enzyme that catalyzes the linked intracellular conversion of NADPH2 to NADP and duroquinone (DQ) to hydroduroquinone (DQH2) in cells. There are different methods to determine NQO1 activity. The classic NQO1 enzyme assay is the usual method for measuring NQO1 activity in cell lysates. We chose to determine the intact-cell activity to investigate the effect of the four compounds Quercetin (Q), Epigallocatechin-3-gallate, (EGCG), indole-3-carbinol (I3C), and Sulforaphane (SFN) in stimulating NQO1 activity. In brief, DQ-mediated reduction of the ce

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Kappes, F., J. Fahrer, M. S. Khodadoust, et al. "DEK Is a Poly(ADP-Ribose) Acceptor in Apoptosis and Mediates Resistance to Genotoxic Stress." Molecular and Cellular Biology 28, no. 10 (2008): 3245–57. http://dx.doi.org/10.1128/mcb.01921-07.

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ABSTRACT DEK is a nuclear phosphoprotein implicated in oncogenesis and autoimmunity and a major component of metazoan chromatin. The intracellular cues that control the binding of DEK to DNA and its pleiotropic functions in DNA- and RNA-dependent processes have remained mainly elusive so far. Our recent finding that the phosphorylation status of DEK is altered during death receptor-mediated apoptosis suggested a potential involvement of DEK in stress signaling. In this study, we show that in cells committed to die, a portion of the cellular DEK pool is extensively posttranslationally modified

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Taylor, Cormac T. "Mitochondria and cellular oxygen sensing in the HIF pathway." Biochemical Journal 409, no. 1 (2007): 19–26. http://dx.doi.org/10.1042/bj20071249.

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Mitochondrial respiration is responsible for more than 90% of oxygen consumption in humans. Cells utilize oxygen as the final electron acceptor in the aerobic metabolism of glucose to generate ATP which fuels most active cellular processes. Consequently, a drop in tissue oxygen levels to the point where oxygen demand exceeds supply (termed hypoxia) leads rapidly to metabolic crisis and represents a severe threat to ongoing physiological function and ultimately, viability. Because of the central role of oxygen in metabolism, it is perhaps not surprising that we have evolved an efficient and rap

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Nikitjuka, Anna, Kristaps Krims-Davis, Iveta Kaņepe-Lapsa, Melita Ozola, and Raivis Žalubovskis. "May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?" Molecules 28, no. 18 (2023): 6647. http://dx.doi.org/10.3390/molecules28186647.

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Thioredoxin reductase is an essential enzyme that plays a crucial role in maintaining cellular redox homeostasis by catalyzing the reduction of thioredoxin, which is involved in several vital cellular processes. The overexpression of TrxR is often associated with cancer development. A series of 1,2-dithiolane-4-carboxylic acid analogs were obtained to verify the selectivity of 1,2-dithiolane moiety toward TrxR. Asparagusic acid analogs and their bioisoters remain inactive toward TrxR, which proves the inability of the 1,2-dithiolane moiety to serve as a pharmacophore during the interaction wit

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He, Xian-Hui, Yi Liu, Li-Hui Xu, and Yao-Ying Zeng. "Cloning and Identification of Two Novel Splice Variants of Human PD-L2." Acta Biochimica et Biophysica Sinica 36, no. 4 (2004): 284–89. http://dx.doi.org/10.1093/abbs/36.4.284.

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Abstract PD-L2, a newly identified member of B7 family, plays a role in down-regulating T cell responses. The common PD-L2 mRNA (type I) is the splicing product containing all 6 exons. We report here the identification of two human PD-L2 splice variants in activated leukocytes. One splice variant (type II) is generated through splicing out exon 3 encoding Ig constant-like domain; it retains all other regions without a frame shift. The other variant (type III) is created by splicing out exon 3 to an alternative acceptor site 5 bp downstream of the canonical acceptor site, leading to a frame shi

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Preaudat, M., J. Ouled-Diaf, B. Alpha-Bazin, et al. "A Homogeneous Caspase-3 Activity Assay Using HTRF® Technology." Journal of Biomolecular Screening 7, no. 3 (2002): 267–74. http://dx.doi.org/10.1177/108705710200700310.

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Caspases are cysteine proteases presenting a conserved active site that cleaves protein substrates at a highly specific position. They are involved in different aspects of the active cell death pathway. Most of them act through proteolytic degradations of cellular components. This paper describes the assay development, assay validation, and screening for inhibitors of this enzyme, which could be potential drug candidates. The assay uses homogeneous time-resolved fluorescence based on energy transfer from europium cryptate as donor to cross-linked allophyco-cyanin as acceptor (XL665). A double-

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Shourjya, Sanyal, F. Coker David, and MacKernan Donal. "Unimolecular FRET Sensors: Simple Linker Designs and Properties." Nano Communication Networks 18 (November 12, 2018): 44–50. https://doi.org/10.1016/j.nancom.2018.10.003.

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Protein activation and deactivation is central to a variety of biological mechanisms, including cellular signaling and transport. Unimolecular fluorescent resonance energy transfer (FRET) probes are a class of fusion protein sensors that allow biologists to visualize using an optical microscope whether specific proteins are activated due to the presence nearby of small drug-like signaling molecules, ligands or analytes. Often such probes comprise a donor fluorescent protein attached to a ligand binding domain, a sensor or reporter domain attached to the accep

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