Academic literature on the topic 'Cellular bioenergetics'

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Journal articles on the topic "Cellular bioenergetics"

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Hill, Bradford G., Gloria A. Benavides, Jack R. Lancaster, et al. "Integration of cellular bioenergetics with mitochondrial quality control and autophagy." Biological Chemistry 393, no. 12 (2012): 1485–512. http://dx.doi.org/10.1515/hsz-2012-0198.

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Abstract Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes, cancer and neurodegeneration. Recent advances in cellular bioenergetics have shown that many cells maintain a substantial bioenergetic reserve capacity, which is a prospective index of ‘healthy’ mitochondrial populations. The bioenergetics of the cell are likely regulated by energy requirements and substrate availability. Additionally, the overall quality of the mitochondrial population and the relative abundance of mitochondria
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Augsburger, Fiona, Elisa B. Randi, Mathieu Jendly, Kelly Ascencao, Nahzli Dilek, and Csaba Szabo. "Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells." Biomolecules 10, no. 3 (2020): 447. http://dx.doi.org/10.3390/biom10030447.

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3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells. The current study was designed to investigate the functional role of 3-MST’s catalytic activity in the murine colon cancer cell line CT26. The novel pharmacological 3-MST inhibitor HMPSNE was used to assess cancer cell proliferation, migration and bioenergetics in vitro. Methods included measurements of cell viability (MTT and LDH assays), cell proliferation and in vitro wound healing (IncuCyte) and cellular bioenergetics (Seahorse extrace
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Lehrer, H. Matthew, Lauren Chu, Martica Hall, and Kyle Murdock. "009 Self-Reported Sleep Efficiency and Duration are Associated with Systemic Bioenergetic Function in Community-Dwelling Adults." Sleep 44, Supplement_2 (2021): A4. http://dx.doi.org/10.1093/sleep/zsab072.008.

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Abstract Introduction Sleep is important for aging, health, and disease, but its cellular role in these outcomes is poorly understood. Basic research suggests that disturbed and insufficient sleep impair mitochondrial bioenergetics, which is involved in numerous aging-related chronic conditions. However, the relationship between sleep and bioenergetics has not been examined in humans. We examined associations of self-reported sleep with systemic bioenergetic function in peripheral blood mononuclear cells (PBMCs) of community-dwelling adults. Methods N = 43 adults (79% female) ages 48–70 (M = 6
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Welch, G. R. "Bioenergetics and the cellular microenvironment." Pure and Applied Chemistry 65, no. 9 (1993): 1907–14. http://dx.doi.org/10.1351/pac199365091907.

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Acuña-Castroviejo, Darío, Miguel Martín, Manuel Macías, et al. "Melatonin, mitochondria, and cellular bioenergetics." Journal of Pineal Research 30, no. 2 (2001): 65–74. http://dx.doi.org/10.1034/j.1600-079x.2001.300201.x.

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Heiden, Matthew Vander. "Cellular Bioenergetics in Lymphoid Neoplasia." Blood 118, no. 21 (2011): SCI—25—SCI—25. http://dx.doi.org/10.1182/blood.v118.21.sci-25.sci-25.

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Abstract Abstract SCI-25 Many cancer cells metabolize glucose by aerobic glycolysis, a phenomenon characterized by increased glycolysis with lactate production and decreased oxidative phosphorylation. We have argued that alterations in cell metabolism associated with cancer may be selected by cancer cells to meet the distinct metabolic needs of proliferation. Unlike metabolism in differentiated cells, which is geared toward efficient ATP generation, the metabolism in cancer cells must be adapted to facilitate the accumulation of biomass. Cancer cells divert a larger fraction of their nutrient
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Davies, Karen M., and Bertram Daum. "Role of cryo-ET in membrane bioenergetics research." Biochemical Society Transactions 41, no. 5 (2013): 1227–34. http://dx.doi.org/10.1042/bst20130029.

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To truly understand bioenergetic processes such as ATP synthesis, membrane-bound substrate transport or flagellar rotation, systems need to be analysed in a cellular context. Cryo-ET (cryo-electron tomography) is an essential part of this process, as it is currently the only technique which can directly determine the spatial organization of proteins at the level of both the cell and the individual protein complexes. The need to assess bioenergetic processes at a cellular level is becoming more and more apparent with the increasing interest in mitochondrial diseases. In recent years, cryo-ET ha
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Chacko, Balu K., Philip A. Kramer, Saranya Ravi, et al. "The Bioenergetic Health Index: a new concept in mitochondrial translational research." Clinical Science 127, no. 6 (2014): 367–73. http://dx.doi.org/10.1042/cs20140101.

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Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the ‘canary in the coal mine’ by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and pr
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Narchi, Hassib, Pramathan Thachillath, and Abdul-Kader Souid. "Forebrain cellular bioenergetics in neonatal mice." Journal of Neonatal-Perinatal Medicine 11, no. 1 (2018): 79–86. http://dx.doi.org/10.3233/npm-181737.

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Acin-Perez, Rebeca, Cristiane Benincá, Byourak Shabane, Orian S. Shirihai, and Linsey Stiles. "Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives." Life 11, no. 9 (2021): 949. http://dx.doi.org/10.3390/life11090949.

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Mitochondrial bioenergetic function is a central component of cellular metabolism in health and disease. Mitochondrial oxidative phosphorylation is critical for maintaining energetic homeostasis, and impairment of mitochondrial function underlies the development and progression of metabolic diseases and aging. However, measurement of mitochondrial bioenergetic function can be challenging in human samples due to limitations in the size of the collected sample. Furthermore, the collection of samples from human cohorts is often spread over multiple days and locations, which makes immediate sample
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Dissertations / Theses on the topic "Cellular bioenergetics"

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Spickett, Corinne Michelle. "NMR studies of cellular bioenergetics." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257961.

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Cui, Xiaoyu. "Regulation of Cellular Bioenergetics by Na/K-ATPase." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1481294995657855.

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Kelly, R. A. "Biochemical thermodynamic modelling of cellular bioenergetics : a quantitative systems pharmacology approach." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/7754/.

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In this thesis, thermodynamic-based mathematical modelling is combined with experimental in vitro extracellular flux analysis in order to assess drug redox cycling and cellular bioenergetics. It is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, antimalarial) is related to their ability to accept one or two electrons. However, pharmacological activity via redox cycling is an understated mechanism of toxicity associated with many classes of drugs. In particular, oxidative stress as a result of redox cycling plays a pivotal role in the cause of cardiac
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Štajer, Valdemar. "EFEKTI AEROBNOG I ANAEROBNOG VEŽBANjA MAKSIMALNOG INTENZITETA NA BIOMARKERE PERIFERNOG ZAMORA I ĆELIJSKE BIOENERGETIKE KOD MLADIH MUŠKARACA I ŽENA." Phd thesis, Univerzitet u Novom Sadu, Fakultet sporta i fizičkog vaspitanja u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=111943&source=NDLTD&language=en.

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Primena biomarkera ćelijske energetike, uključujući indikatore metabolizma kreatina u krvi, je relativno novijeg datuma, gde se ovi indikatori koriste kao mogući pokazatelji stanja organizma pri maksimalno intenzivnim fizičkim aktivnostima. Cilj istraživanja je obuhvatao utvrđivanje efekata pojedinačnih epizoda aerobnog i anaerobnog vežbanja maksimalnog intenziteta na biomarkere perifernog zamora i ćelijske bioenergetike kod mladih muškaraca i žena. Istraživanje je dizajnirano tako da obuhvati populaciju fizički aktivnih muškaraca i žena, kao i populaciju aktivnih sportista. U pr
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Buranasudja, Visarut. "DNA damage and disruption of cellular bioenergetics contribute to the anti-cancer effects of pharmacological ascorbate." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6551.

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The clinical potential of pharmacological ascorbate (P-AscH-; IV delivery achieving mM concentrations in blood) as an adjuvant in cancer therapy is being re-evaluated. At mM concentrations, P-AscH- is thought to exhibit anti-cancer activity via generation of a flux of H2O2 in tumors, which leads to oxidative distress. Here, we use cell culture models of pancreatic cancer, MIA PaCa-2, PANC-1, and 339 cells, to examine the effects of P-AscH- on DNA damage, and downstream consequences, including changes in bioenergetics. We have found that the high flux of H2O2 produced by P-AscH- induces both nu
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Doonan, Patrick John. "Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/214818.

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Biochemistry<br>Ph.D.<br>Mitochondrial calcium (Ca2+) uptake has been studied for over five decades, with crucial insights into its underlying mechanisms enabled by development of the chemi-osmotic hypothesis and appreciation of the considerable voltage present across the inner mitochondrial membrane (ΔΨm) generated by proton pumping by the respiratory chain (Carafoli, 1987; Nicholls, 2005). However, the molecules that regulate mitochondrial Ca2+ uptake have only recently been identified (Jiang et. al., 2009; Perocchi et. al., 2010) and further work was needed to clarify how these molecules re
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Kuffner, Kerstin [Verfasser], and Christian H. [Akademischer Betreuer] Wetzel. "Bioenergetics and Major Depressive Disorder - Investigations of Mitochondria Function in a Human Cellular Model / Kerstin Kuffner ; Betreuer: Christian H. Wetzel." Regensburg : Universitätsbibliothek Regensburg, 2020. http://d-nb.info/1214887007/34.

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Kim, Jaeyeon. "Model Analysis of Adipose Tissue and Whole Body Metabolism In Vivo." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1216436630.

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Hamraz, Minoo. "Bioenergetic consequences of the hyperosmotic shock." Thesis, Sorbonne Paris Cité, 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2332&f=17549.

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L'inflammation est associée à des modifications du métabolisme cellulaire avec une glycolyse (libération de lactate) accrue accompagnée d'une baisse de la phosphorylation oxydative mitochondriale. L'inflammation cause l'hyperosmolarité du milieu extracellulaire. Cette thèse examine les effets de l'hyperosmolarité sur le métabolisme énergétique cellulaire. Nous avons mesuré la consommation d'oxygène cellulaire (OCR) et la production d'acide (PPR) c'est à dire de lactate libéré dans le milieu extérieur avec deux approches expérimentales : l'oxygraphie haute résolution (O2k Oroboros instrument) p
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Wright, Muelas Marina. "A systems biology approach to cancer metabolism." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/a-systems-biology-approach-to-cancer-metabolism(27286c8a-0281-4256-b749-2ec9bd36370f).html.

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Cancer cells have been known for some time to have very different metabolismas compared to that of normal non proliferating cells. As metabolism is involvedin almost every aspect of cell function, there has been a recent resurgence ofinterest in inhibiting cancer metabolism as a therapeutic strategy. Inhibitors thatspecifically target altered metabolic components in cancer cells are being developedas antiproliferative agents. However, many such inhibitors have not progressedinto the clinic due to limited efficacy either in vitro or in vivo. In this study weexplore the hypothesis that this is o
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Books on the topic "Cellular bioenergetics"

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Papa, Sergio, Ferruccio Guerrieri, and Joseph M. Tager, eds. Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0.

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Saks, Valdur A., and Renée Ventura-Clapier, eds. Cellular Bioenergetics: Role of Coupled Creatine Kinases. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2612-4.

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Nederkoorn, Paul H. J. Signal transduction by G protein-coupled receptors: Bioenergetics and G protein activation : proton transfer and GTP synthesis to explain the experimental findings. Springer, 1997.

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Cramer, W. A. Energy transduction in biological membranes: A textbook of bioenergetics. Springer-Verlag, 1990.

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Papa, S., Joseph M. Tager, and Ferruccio Guerrieri. Frontiers of Cellular Bioenergetics. Springer My Copy UK, 1999.

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Saks, V. A. Cellular Bioenergetics: Role of Coupled Creatine Kinases. Springer, 2012.

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A, Saks V., and Ventura-Clapier Renée, eds. Cellular bioenergetics: Role of coupled creatine kinases. Kluwer Academic Publishers, 1994.

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(Editor), Valdur A. Saks, and Renée Ventura-Clapier (Editor), eds. Cellular Bioenergetics: Role of Coupled Creatine Kinases (Developments in Molecular and Cellular Biochemistry). Springer, 1994.

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S, Papa, Guerrieri Ferruccio, and Tager J. M, eds. Frontiers of cellular bioenergetics: Molecular biology, biochemistry, and physiopathology. Kluwer Academic/Plenum Press, 1999.

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(Editor), S. Papa, Ferruccio Guerrieri (Editor), and Joseph M. Tager (Editor), eds. Frontiers of Cellular Bioenergetics: Molecular Biology, Biochemistry, and Physiopathology. Springer, 1999.

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Book chapters on the topic "Cellular bioenergetics"

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Ji, Sayer, and Ali Le Vere. "Revisioning Cellular Bioenergetics." In Nutrition and Integrative Medicine. CRC Press, 2018. http://dx.doi.org/10.1201/9781315153155-10.

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Stucki, Jörg W., and Erwin Sigel. "Nonequilibrium Thermodynamics and Cellular Bioenergetics." In Integration of Mitochondrial Function. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2551-0_15.

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Giuffrè, Alessandro, Paolo Sarti, Emilio D’Itri, Gerhard Buse, Tewfik Soulimane, and Maurizio Brunori. "Transient Spectroscopy of the Reaction between Cytochrome c Oxidase and Nitric Oxide." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_10.

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Trumpower, Bernard L. "Energy Transduction in Mitochondrial Respiration by the Proton-Motive Q-Cycle Mechanism of the Cytochrome bc 1 Complex." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_11.

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Yu, Chang-An, Li Zhang, Anatoly M. Kachurin, et al. "The Crystal Structure of Mitochondrial Cytochrome bc 1 Complex." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_12.

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Link, Thomas A. "Structural Aspects of the Cytochrome bc 1 Complex." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_13.

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Schulte, Ulrich, and Hanns Weiss. "Structure, Function, and Biogenesis of Respiratory Complex I." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_14.

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Bianchet, Mario A., Peter L. Pedersen, and L. Mario Amzel. "Structure of F1 -ATPase and the Mechanism of ATP Synthesis— Hydrolysis." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_15.

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Souid, Abdul-Kader, and Harvey S. Penefsky. "Mechanism of ATP Synthesis by Mitochondrial ATP Synthase." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_16.

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Futai, Masamitsu, and Hiroshi Omote. "Mutational Analysis of ATP Synthase An Approach to Catalysis and Energy Coupling." In Frontiers of Cellular Bioenergetics. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4843-0_17.

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Conference papers on the topic "Cellular bioenergetics"

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Xu, Weiling, Suzy A. Comhair, Allison J. Janocha, Lori A. Mavrakis, and Serpil C. Erzurum. "Cellular Bioenergetics In Asthma." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2807.

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Biniecka, Monika, Emese Balogh, Aisling Kennedy, Chin T. Ng, Douglas J. Veale, and Ursula Fearon. "04.20 Oxidative stress alters cellular bioenergetics in inflammatory arthritis." In 37th European Workshop for Rheumatology Research 2–4 March 2017 Athens, Greece. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2016-211051.20.

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Xu, Weiling, Suzy A. A. Comhair, Allison J. Janocha, Lori A. Mavrakis, and Serpil C. Erzurum. "Alteration Of Nitric Oxide Synthesis Related To Abnormal Cellular Bioenergetics In Asthmatic Airway Epithelium." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1436.

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Chen, Shanwen, Pengyuan Wang, Yisheng Pan та Yucun Liu. "Abstract 5840: Inhibition of cystathionine-β-synthase (CBS) sensitizes colon cancer cells to 5-FU via increasing apoptosis and inhibiting cellular bioenergetics". У Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5840.

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Ferreira, Rodrigo, Christian Maibohm, Oscar F. Silvestre, Rosa Romero, Helder Crespo, and Jana B. Nieder. "Few-Cycle Laser for the in Vitro Study of Cellular Bioenergetics during Therapeutic Treatment with the Anticancer Drug Doxorubicin in its Free and Liposomal Nanocarrier Form." In 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC). IEEE, 2019. http://dx.doi.org/10.1109/cleoe-eqec.2019.8871603.

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Fan, Yongjun, Kathleen G. Dickman, and Wei‐Xing Zong. "Abstract B96: Akt and c‐Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-b96.

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