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Journal articles on the topic 'Cellular bloke'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gordić, Radojko, Miladin Gligorić, Darko Reljić, and Đorđe Janaćković. "Obtaining optimal CaO-lime reactivity for uniform extraction of H2 in the "gas-cellular" building block." Tehnika 77, no. 5 (2022): 525–30. http://dx.doi.org/10.5937/tehnika2205525g.

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In this paper quicklime CaO used for the production of aerated blocks needs to have a specific reactivity in order to ensure that hydrogen H2 in "gas-cellular" building blok is released evenly. In the production of gas silicate, the agent used for the creation of pores is usually aluminum powder, which reacts with Ca(OH)2 to release hydrogen, which in turn causes the swelling of the material and the forming of pores. To generate quicklime CaO with a specific reactivity, it is necessary to accurately determine the rock mass, calcination temperature and residence time in the calcination zone dur

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2

Zhao, Ming, Blake R. Rushing, Zhikun Ma, et al. "Abstract 280: ALDH2 knockout dysregulates arginine and proline metabolism in SK-BR-3 breast cancer cells." Cancer Research 85, no. 8_Supplement_1 (2025): 280. https://doi.org/10.1158/1538-7445.am2025-280.

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Abstract Aldehyde dehydrogenase 2 (ALDH2) mitigates cellular stress by detoxifying reactive aldehydes produced during alcohol exposure and endogenous metabolic processes. The ALDH2*2 variant, prevalent in East Asian populations, has decreased catalytic activity, which is linked to an increased risk of cancer and other diseases. While the effects of ALDH2 deficiency on cellular stress responses are well documented, the specific metabolic dysregulations arising from this deficiency require further investigation. To explore the impact of ALDH2 deficiency on metabolism and cellular stress in breas

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Friedersdorf, Matthew, Devon Blake, Sarah Thompson, Krista Marran, and Jessica Sorrentino. "Abstract PO5-27-09: Pharmacological eIF4E inhibition suppresses anti-tumor activity in ER+ breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO5–27–09—PO5–27–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-27-09.

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Abstract Elevated levels of eukaryotic initiation factor 4E (eIF4E) are found in a broad range of cancers, including breast, and have been associated with aggressive, drug resistant tumors. Furthermore, elevated eIF4E activity is sufficient to cause transformation in various cancers, while inhibition suppresses tumor growth. eIF4E, the main regulator and rate limiting factor of protein synthesis, is the downstream integrator of several important oncogenic signaling pathways (PI3K/AKT/mTOR, Ras/Raf/MEK, and Myc). Activation of eIF4E results in increased protein levels of key proliferation and m

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4

Seaver, Elaine C. "Annelids shed light on the evolution of spiralian development." Canadian Journal of Zoology 95, no. 10 (2017): 705–12. http://dx.doi.org/10.1139/cjz-2016-0261.

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Spiralian development is characterized by stereotypic cell geometry and spindle orientation in early cleavage stage embryos, as well as conservation of ultimate fates of descendent clones. Diverse taxa such as molluscs, annelids, flatworms, and nemerteans exhibit spiralian development, but it is a mystery how such a conserved developmental program gives rise to such diverse body plans. This review highlights examples of variation during early development among spiralians, emphasizing recent experimental studies in the annelid Capitella teleta Blake, Grassle and Eckelbarger, 2009. Intracellular

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Iolchiev, B. S., I. P. Novgorodova, Yu A. Prytkov, et al. "The influence of biotic factors on the parameters of the nucleolus." Agrarian science, no. 12 (January 18, 2023): 76–80. http://dx.doi.org/10.32634/0869-8155-2022-365-12-76-80.

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Relevance. The nucleolus regulates many aspects of cell physiology, including genome organization, stress response, aging, and lifespan. The number of visible nucleoli per cell varies depending on the cell cycle, cellular activity, or differentiation status. The aim of the study was to study the influence of abiotic factors on the parameters of animal nucleoli depending on their species (genus Ovis and genus Capra) and type of crossing (interspecific hybrids). Materials and methods. The studies were carried out at the Federal Research Center for Animal Husbandry named after Academy Member L. K

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Zhou, Feng, Xian Wang, Baoyu Han, et al. "Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization." Molecular Pain 17 (January 2021): 174480692199652. http://dx.doi.org/10.1177/1744806921996520.

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Microglia activation and subsequent pro-inflammatory responses play a key role in the development of neuropathic pain. The process of microglia polarization towards pro-inflammatory phenotype often occurs during neuroinflammation. Recent studies have demonstrated an active role for the gut microbiota in promoting microglial full maturation and inflammatory capabilities via the production of Short-Chain Fatty Acids (SCFAs). However, it remains unclear whether SCFAs is involved in pro-inflammatory/anti-inflammatory phenotypes microglia polarization in the neuropathic pain. In the present study,

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7

Ilhami, Yose Ramda. "PERANAN DURASI QRS DAN SKOR QRS SELVESTER DALAM KEBERHASILAN REPERFUSI MIOKARD." Majalah Kedokteran Andalas 38, no. 4 (2016): 218. http://dx.doi.org/10.22338/mka.v38.i4.p218-227.2015.

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AbstrakPerubahan gambaran elektrokardiogram (EKG) terjadi pada fase akut IMA EST baik berupa perubahan repolarisasi ataupun perubahan depolarisasi. Skor QRS Selvester dan pemanjangan kompleks QRS merupakan parameter yang digunakan untuk memperkirakan luas infark dan penilaian iskemia. Tujuan penulisan ini adalah untuk mengetahui mekanisme perubahan durasi QRS dan skor QRS Selvester setelah reperfusi yang optimal. Penulisan artikel ini berdasarkan studi kepustakaan yang terkait dengan peranan durasi QRS dan skor QRS Selvester serta keberhasilan reperfusi miokard. Iskemia mengakibatkan perubahan

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8

Friedersdorf, Matthew B., Devon R. Blake, Sarah E. Thompson, et al. "Abstract 682: Development of novel eIF4E inhibitors to potently and selectively suppress tumor growth across multiple indications." Cancer Research 84, no. 6_Supplement (2024): 682. http://dx.doi.org/10.1158/1538-7445.am2024-682.

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Abstract Despite considerable progress in treating cancer, drug resistance remains the primary hurdle to achieving cures in patients. Tumors often develop resistance through reactivation of the drug-targeted pathway, or activation of alternative parallel pathways, thereby maintaining the original downstream signaling effects. One of the furthest downstream effectors and critical nodes for many oncogenic signaling pathways is eukaryotic translation initiation factor 4E (eIF4E); the main regulator and rate limiting factor for protein synthesis. eIF4E is reactivated by many resistance mechanisms

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Pal, Sumanta K., Benjamin Garmezy, Helen Budworth та ін. "Abstract CT187: A phase 1/2 first in human study of ADI-270, an armored allogeneic anti-CD70 chimeric antigen receptor (CAR)γδT cell therapy, in patients (pts) with relapsed or refractory (R/R) clear cell renal cell carcinoma (ccRCC) (trial in progress)". Cancer Research 85, № 8_Supplement_2 (2025): CT187. https://doi.org/10.1158/1538-7445.am2025-ct187.

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Abstract Background: CD70 is a type II transmembrane protein of the tumor necrosis factor superfamily normally transiently expressed in activated lymphocytes, including B, T, NK, and mature dendritic cells. CD70 is aberrantly expressed in solid and hematologic cancers and is implicated in enhanced growth, metastasis, and immune evasion and suppression. In ccRCC, CD70 expression is increased in the tumor microenvironment and on malignant cells. Despite advancements in the treatment of patients with metastatic RCC, the 5 year survival rate is 15% and there remains an unmet need. ADI-270 is an in

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Meyer, Philipp, Ruzica Bago, Balasz Pograny, et al. "Abstract 5516: Deciphering mechanism of resistance to anti EGFR treatment regimen in a NSCLC PDX model." Cancer Research 85, no. 8_Supplement_1 (2025): 5516. https://doi.org/10.1158/1538-7445.am2025-5516.

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Abstract Acquired resistance prevents patients from long term benefits of targeted therapies in many different cancer types. Overactivation of EGFR in malignant cells is a prominent example for acquired resistance since anti-EGFR treatment in NSCLC patients often starts showing loss of activity after a certain period. We have developed three NSCLC PDX lines carrying an acquired resistance towards Gefitinib, a highly selective EGFR inhibitor. All three sublines depict a specific mutational and gene expression pattern. These PDX models were now further characterized by assessment of in vivo sens

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Okamura, Naoka, Katsuya Ikuta, Hiroki Tanaka, et al. "Anti-Proliferative Effect of Itraconazole On ALCL-Derived Cell Line." Blood 120, no. 21 (2012): 1367. http://dx.doi.org/10.1182/blood.v120.21.1367.1367.

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Abstract Abstract 1367 Background: Itraconazole (ITCZ) has been widely used for the treatment of fungal infection in the treatment of hematological malignancies. Recently, an anti-proliferative effect of ITCZ has been reported in solid tumors (Kim J et al. Cancer Cell 2010;17:388–399, Blake T et al. Cancer Res 2011;71:6764–6772). However, there has been no report on the effect of ITCZ on hematological malignancies. Therefore, we aimed to investigate the anti-proliferative effect of ITCZ on hematological malignancies in the present study. Methods: Daudi (Human Burkitt's lymphoma cell line), Jur

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12

Khatri, B., T. R. Reksten, K. L. Tessneer, et al. "OP0047 GENOME-WIDE ASSOCIATION STUDY OF SJÖGREN’S SYNDROME IDENTIFIES TEN NEW RISK LOCI." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 30.2–31. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3857.

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Background:Sjögren’s syndrome (SS) is a complex autoimmune disease with exocrine gland dysfunction leading to substantial morbidity. There are 10 published genetic susceptibility loci.Objectives:Our genome-wide association study (GWAS) aimed to identify additional risk loci of genome-wide significance (GWS; p<5E-08) in European-derived primary SS.Methods:A total of 3232 cases and 17481 controls genotyped on GWAS arrays and 619 cases and 6171 controls genotyped on ImmunoChip (IC) arrays were imputed after quality control. Logistic regression was calculated adjusting for ancestry using the fi

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13

C.H., Venkata Suneel Kumar, and Sivasankar R. "Study of prenatal exposure to 4-tetra octyl phenol on lipid peroxidation and activity levels of anti-oxidant enzymes in the testis of mature rats." Biolife 4, no. 4 (2022): 715–22. https://doi.org/10.5281/zenodo.7350845.

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<strong>ABSTRACT</strong> 4-tert-Octylphenol (OP) is major degradations products of alkylphenol ethoxylates. These chemicals are found in the waste water and sludge of sewage treatment works and river sediments. Alkylphenols are also found in drinking water.  Thus, alkylphenols are widely dispersed in the environment. Several alkylphenols, including 4-tert-octylphenol have included altered sex hormone levels and hypothalamic-pituitary outcomes, impaired spermatogenesis 4-tert-octylphenol is not considered directly genotoxic. The present study aims at evaluating the effects of prenatal exp

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14

Shanaj Parvin, Most, and Md Ehsanul Haque. "Microrna Regulation of Nodule Zone-Specific Gene Expression In Soybean." Journal of Natural Products and Natural Products Synthesis 1, no. 1 (2021): 15–21. http://dx.doi.org/10.55124/jnns.v1i1.82.

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Nitrogen is a paramount important essential element for all living organisms. It has been found to bea crucial structural component of proteins, nucleic acids, enzymes and other cellular constituents which are inevitable for all forms of life. In the atmosphere, the percentage of nitrogen is very high (N2, 78%) compared to other inorganic gases. However, most organisms have practically no direct access to this nitrogen. While plants can not directly uptake nitrogen from atmosphere, they are capable of assimilating other forms of nitrogen, for example ammonium (NH4+) and nitrate (NO3-). For agr

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15

BERDIEV, OLEG, and DENIS FEDOROVICH. "The dependence of the stability of the vertical wall of the cells on the gas pressure in cellular bloke of aviapanel." June 21, 2017. https://doi.org/10.5281/zenodo.808907.

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In the aircrafts whose structure is severely affected by alternating tensile and compressive effects, they widely use multi-layer composite panels containing a rigid cellular insert between two covers apart, in which there is a special longitudinal <em>shirring</em> cell wall. The constructions of the kind are usually called <em>sandwich</em>. When designing an aircraft panel of the <em>sandwich</em> type, the developers must take into consideration a certain deterrent, because the cellular placeholders have the utmost height (the thickness of the panel) conditioned by the limitation of mechan

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16

Tang, Shu-Kun, Xiao-Yang Zhi, Yao Zhang, et al. "Cellular differentiation into hyphae and spores in halophilic archaea." Nature Communications 14, no. 1 (2023). http://dx.doi.org/10.1038/s41467-023-37389-w.

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AbstractSeveral groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria of the genus Streptomyces form multicellular vegetative hyphae, aerial hyphae, and spores. However, similar life cycles have not yet been described for archaea. Here, we show that several haloarchaea of the family Halobacteriaceae display a life cycle resembling that of Streptomyces bacteria. Strain YIM 93972 (isolated from a salt marsh) undergoes cellular differentiation into mycelia and spores. Other closely related strains are also able to

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17

"Performansi Throughput Jaringan 4G Pada Lantai 2 Blok 6 Kampus PCR." Jurnal Elektro dan Mesin Terapan (ELEMENTER) 10, Vol.10 No. 1 (2024) (2024): 35–42. http://dx.doi.org/10.35143/elementer.v10i1.6195.

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Nowadays, 4G cellular service has become a basic need especially for campus communities. Information exchange and learning processes often utilize technology in this service. Block 6, floor 2 of the PCR campus consists of 2 lecturer rooms, 4 laboratories, 1 meeting room and 1 research room. Of course, this is one of the spots in PCR where 4G service is needed. Of the several 4G service providers in Indonesia, Telkomsel is the operator that has the most customers. 4G network performance can be seen in several parameters such as RSRP, RSRQ, CSFB, Throughput and SINR. These parameters are obtaine

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