Relevant bibliographies by topics / Cellular contexts

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cellular contexts'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Cellular contexts"

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Nair, Surag, Daniel S. Kim, Jacob Perricone, and Anshul Kundaje. "Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts." Bioinformatics 35, no. 14 (July 2019): i108—i116. http://dx.doi.org/10.1093/bioinformatics/btz352.

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Abstract Motivation Genome-wide profiles of chromatin accessibility and gene expression in diverse cellular contexts are critical to decipher the dynamics of transcriptional regulation. Recently, convolutional neural networks have been used to learn predictive cis-regulatory DNA sequence models of context-specific chromatin accessibility landscapes. However, these context-specific regulatory sequence models cannot generalize predictions across cell types. Results We introduce multi-modal, residual neural network architectures that integrate cis-regulatory sequence and context-specific expression of trans-regulators to predict genome-wide chromatin accessibility profiles across cellular contexts. We show that the average accessibility of a genomic region across training contexts can be a surprisingly powerful predictor. We leverage this feature and employ novel strategies for training models to enhance genome-wide prediction of shared and context-specific chromatin accessible sites across cell types. We interpret the models to reveal insights into cis- and trans-regulation of chromatin dynamics across 123 diverse cellular contexts. Availability and implementation The code is available at https://github.com/kundajelab/ChromDragoNN. Supplementary information Supplementary data are available at Bioinformatics online.
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Schwartz, Michael H., and Tao Pan. "Function and origin of mistranslation in distinct cellular contexts." Critical Reviews in Biochemistry and Molecular Biology 52, no. 2 (January 11, 2017): 205–19. http://dx.doi.org/10.1080/10409238.2016.1274284.

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Suresh, Nallan C., and Gerard J. C. Gaalman. "Performance evaluation of cellular layouts: Extension to DRC system contexts." International Journal of Production Research 38, no. 17 (November 2000): 4393–402. http://dx.doi.org/10.1080/00207540050205172.

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Dong, Xianjun, Melissa C. Greven, Anshul Kundaje, Sarah Djebali, James B. Brown, Chao Cheng, Thomas R. Gingeras, et al. "Modeling gene expression using chromatin features in various cellular contexts." Genome Biology 13, no. 9 (2012): R53. http://dx.doi.org/10.1186/gb-2012-13-9-r53.

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Angermann, Bastian R., Frederick Klauschen, Alex D. Garcia, Thorsten Prustel, Fengkai Zhang, Ronald N. Germain, and Martin Meier-Schellersheim. "Computational modeling of cellular signaling processes embedded into dynamic spatial contexts." Nature Methods 9, no. 3 (January 29, 2012): 283–89. http://dx.doi.org/10.1038/nmeth.1861.

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de Jong, Paulus T. V. M. "Myopia: its historical contexts." British Journal of Ophthalmology 102, no. 8 (February 3, 2018): 1021–27. http://dx.doi.org/10.1136/bjophthalmol-2017-311625.

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Worldwide, and especially in Asia, myopia is a major vision-threatening disorder. From AD 1600 on, to prevent myopia, authors warned against near work without sufficient pauses. There was an abundance of theories about the causes of myopia, the most common one being the necessity of extra convergence on nearby work with thickened extraocular muscles and elevated intraocular pressure. Ocular tenotomies against myopia were in vogue for a while. Axial lengthening of the eye in myopia was mentioned around 1700, but it took 150 years to become accepted as the most prevalent sign of high myopia. In 1864, a lucid concept of myopia and other ametropias arose through a clear separation between accommodation and refraction. Posterior staphyloma was known around 1800 and its association with myopia became evident some 30 years later. There still seems to be no generally accepted classification of myopia and particularly not of degenerative or pathologic myopia. This review focuses on myopia from 350 BC until the 21st century and on the earliest writings on the histology of eyes with posterior staphyloma. A proposal for myopia classification is given.
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Nam, Jin-Wu, Olivia S. Rissland, David Koppstein, Cei Abreu-Goodger, Calvin H. Jan, Vikram Agarwal, Muhammed A. Yildirim, Antony Rodriguez, and David P. Bartel. "Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting." Molecular Cell 53, no. 6 (March 2014): 1031–43. http://dx.doi.org/10.1016/j.molcel.2014.02.013.

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Schwaid, Adam G., and Ivan Cornella-Taracido. "Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts." Journal of Medicinal Chemistry 61, no. 5 (August 18, 2017): 1767–73. http://dx.doi.org/10.1021/acs.jmedchem.7b00762.

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Ling, Guy, Danielle Miller, Rasmus Nielsen, and Adi Stern. "A Bayesian Framework for Inferring the Influence of Sequence Context on Point Mutations." Molecular Biology and Evolution 37, no. 3 (November 5, 2019): 893–903. http://dx.doi.org/10.1093/molbev/msz248.

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Abstract The probability of point mutations is expected to be highly influenced by the flanking nucleotides that surround them, known as the sequence context. This phenomenon may be mainly attributed to the enzyme that modifies or mutates the genetic material, because most enzymes tend to have specific sequence contexts that dictate their activity. Here, we develop a statistical model that allows for the detection and evaluation of the effects of different sequence contexts on mutation rates from deep population sequencing data. This task is computationally challenging, as the complexity of the model increases exponentially as the context size increases. We established our novel Bayesian method based on sparse model selection methods, with the leading assumption that the number of actual sequence contexts that directly influence mutation rates is minuscule compared with the number of possible sequence contexts. We show that our method is highly accurate on simulated data using pentanucleotide contexts, even when accounting for noisy data. We next analyze empirical population sequencing data from polioviruses and HIV-1 and detect a significant enrichment in sequence contexts associated with deamination by the cellular deaminases ADAR 1/2 and APOBEC3G, respectively. In the current era, where next-generation sequencing data are highly abundant, our approach can be used on any population sequencing data to reveal context-dependent base alterations and may assist in the discovery of novel mutable sites or editing sites.
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Tien, An-Chi, Akhila Rajan, and Hugo J. Bellen. "A Notch updated." Journal of Cell Biology 184, no. 5 (March 2, 2009): 621–29. http://dx.doi.org/10.1083/jcb.200811141.

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Cell–cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation. These include complex sugar modifications in the extracellular domain as well as transit of Notch through defined cellular compartments, including specific endosomes.
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Dissertations / Theses on the topic "Cellular contexts"

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Panzilius, Elena [Verfasser], and Magdalena [Akademischer Betreuer] Götz. "Dissection and identification of cellular contexts that determine sensitivity to ferroptosis in human mammary epithelial cells and breast cancer / Elena Panzilius ; Betreuer: Magdalena Götz." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/121603916X/34.

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Lopez, Cécile. "Etude des mécanismes cellulaires et moléculaires des leucémies pédiatriques à mauvais pronostic présentant la fusion ETO2-GLIS2." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS413.

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La fusion ETO2-GLIS2, récemment découverte dans les leucémies aiguës mégacaryoblastiques (LAM-M7) et d’autres sous-types de leucémies aiguës myéloïdes (LAM), est associée à un mauvais pronostic.L’objectif de ce travail a été d’étudier les mécanismes mis en jeu par ETO2-GLIS2 dans les cellules leucémiques ainsi que son association spécifique avec les leucémies pédiatriques. Par des analyses moléculaires, nous avons montré que ETO2-GLIS2 se fixe à l’ADN via la partie GLIS2 ainsi que via ETO2 et ses partenaires (incluant GATA, ETS, RUNX) entrainant ainsi une forte dérégulation de l’expression de facteurs de transcription incluant ERG et GATA1.J’ai développé un modèle murin inductible de la fusion ETO2-GLIS2 qui reproduit efficacement les différentes hémopathies observées chez l’Homme. Ce modèle a permis d’observer l’influence du stade développemental (hématopoïèse fœtale vs. adulte) et du type cellulaire (cellule souche hématopoïétique vs. Progéniteur multipotent) sur le phénotype et l’agressivité des leucémies. De plus, la dérégulation transcriptionnelle imposée par ETO2-GLIS2 est différente en fonction du contexte cellulaire. Dans l’ensemble ces résultats indiquent que la fusion ETO2-GLIS2 est suffisante pour induire une leucémie dont le phénotype et l’agressivité sont dépendants du contexte cellulaire dans lequel l’oncogène est introduit. Ils indiquent également que les changements cellulaires et moléculaires au cours du développement sont à l’origine de la forte prévalence des LAM-M7 chez les enfants
The ETO2-GLIS2 fusion, recently discovered in acute megakaryoblastic leukemia (AMKL) and other subtypes of acute myeloid leukemia (AML), is associated with poor prognosis.The aim of this work was to study the mechanisms involved in ETO2-GLIS2 leukemic cells and its specific association with pediatric leukemia.Molecular analyses have shown that ETO2-GLIS2 binds to DNA via the GLIS2 moiety as well as via ETO2 and its partners (including GATA, ETS, RUNX), leading to a strong dysregulation of the expression of transcription factors including ERG and GATA1.I have developed an inducible murine model of ETO2-GLIS2 fusion that efficiently reproduces the different hematopoietic malignancies observed in humans. We were able to observe the influence of developmental stage (fetal vs. Adulte hematopoiesis) and cell type (hematopoietic stem cell vs. Multipotant progenitor) on the phenotype and aggressiveness of leukemia. In addition, the transcriptional dysregulation imposed by ETO2-GLIS2 was different according to the cellular context.Overall, these results indicate that ETO2-GLIS2 fusion is sufficient to induce leukemia whose phenotype and aggressiveness are dependent on the cellular context in which the oncogene is expressed. They also indicate that cellular and molecular changes during development are responsible for the high prevalence of AMKL in children
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Hashimoto, Kyoichi. "Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior." Kyoto University, 2018. http://hdl.handle.net/2433/230974.

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Kühn, Clemens. "Modeling and analysis of yeast osmoadaptation in cellular context." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16287.

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Mathematische Modellierung ist ein wichtiges Werkzeug biologischer Forschung geworden, was sich in der Entstehung von Systembiologie widerspiegelt. Eine erfolgreiche Anwendung mathematischer Methoden auf biologische Fragen erfordert die Zusammenarbeit zwischen experimentell und theoretisch arbeitenden Wissenschaftlern, auch um sicherzustellen, dass die Biologie im Modell adäquat dargestellt wird. Ich präsentiere hier zwei Untersuchungen zur Anpassung von Saccharomyces cere- visae an hyperosmotische Bedingungen: Eine biologisch detailgetreue Beschreibung der Signaltransduktion zur Aktivierung von Hog1 und ein Model, das Anpassung an osmotischen Stress in zellulärem Zusammenhang beschreibt. Die Studie zur Osmoadaptation in zellulären Kontext impliziert, dass Hog1 und Fps1, zwei wichtige Bausteine dieses Adaptationsvorgangs, miteinander in Wechselwirkung treten und dies zur Anpassung beiträgt. Dieses Ergebnis wird durch die Integration verschiedener Hefestämme mit zum Teil gegensätzlich wirkenden Mutationen ermöglicht. Diese Studie offenbart des weiteren, dass die Rolle von Glycerol in der langfristigen Anpassung bisher überschätzt wurde. Die hier präsentierten Ergebnisse zeigen, dass Glycerol als ’Not’-Osmolyt eingesetzt wird und andere Stoffe, z.B. Trehalose, erheblich zu dauerhafter Osmoadaptation beitragen. Durch die Betrachtung des Zustands mehrerer zellulärer Mechansimen wird deutlich, dass Osmoadaptation stark vom Kontext abhängig ist und nicht perfekt ist. Der Preis schlägt sich in langsamerem Wachstum nieder. Zeitabhängige Sensitivitätsanalyse des Modells untermauert diese Hypothese. Die gewählte Perspektive ermöglicht die Betrachtung von intrazellulären Signaltransduktionskomponenten, Metaboliten und des Wachstums. Der Vergleich mit einer Studie, die Anpassung an osmotischen Stress als perfekte Adaptation auf Grund eines vereinfachten Modells beschreibt, hebt die Rolle der gewählten Perspektive zum Verständnis biologischer Systeme hervor.
Mathematical modeling has become an important tool in biology, reflected in the emergence of systems biology. Successful application of mathematical methods to biological questions requires collaboration of experimental and theoretical scientists to identify and study the problem at hand and to ensure that biology and model match. In this thesis, I present two studies on adaptation to hyperosmotic conditions in the yeast Saccharomyces cerevisae: A biologically faithful description of the signaling pathways activating Hog1 and a model integrating the effects of Hog1-activity and cellular metabolism, describing osmoadaptation in cellular context. The study of osmoadaptation in cellular context suggests that Hog1 and Fps1, two crucial components of adaptation, interact upon hyperosmotic stress. This finding is facilitated by incorporating multiple strains with mutations leading to partly oppositional phenotypes. This study further reveals that the role of glycerol in long term adaptation has been overestimated so far. According to the results presented here, glycerol is utilized as an ’emergency’ osmoprotectant and other compounds, e.g. trehalose, contribute significantly to osmoadaptation. Accounting for the state of multiple cellular mechanisms (Hog1-activity, glycolysis, growth) shows that adaptation to hyperosmotic stress and the impact of the individual mechanisms of adaptation is context dependent and that adaptation to sustained osmostress is not perfect, the expense reflected in a reduced growth rate in hyperosmotic medium. Time-dependent sensitivity analysis supports the notion of context. The perspective chosen allows observations on intracellular signaling components, metabolites and growth speed. Comparison with a study that describes osmoadaptation as perfect adaptation highlights the role of this perspective for the conclusions drawn, thus emphasizing the importance of an integrative perspective for understanding biological systems.
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Stoney, Ruth. "Using pathway networks to model context dependent cellular function." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/using-pathway-networks-to-model-context-dependent-cellular-function(562db48d-5e8b-40bb-8457-47c9a3455f9c).html.

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Molecular networks are commonly used to explore cellular organisation and disease mechanisms. Function is studied using molecular interaction networks, such as protein-protein networks. Although much biological insight has been gained using these models of molecular function, they are hindered by their reliance on available experimental data and an inability to capture the complexity of biological processes. Functional modules can be identified based on molecular network topology, making it essential that the edges accurately depict molecular interactions. However, these networks struggle to depict the temporal nature of interactions, giving the impression that all interactions are constant. This misrepresentation can result in functionally heterogeneous clusters. The notoriously inaccurate nature of experimental protein interaction data, along with variable conformity among network clusters and functional modules further impedes functional module extraction. Representation of genes by single nodes artificially merges the functions of pleiotropic genes, distorting the arrangement of function within molecular networks. This thesis therefore explores a more suitable model for representing function. Pathways are composed of sets of proteins that are known to interact within a particular cellular context, corresponding to a discernible biological function. Their representation of context dependent cellular activity makes them ideal for use as nodes within a new pathway level model. Using combinatorial algorithms a reduced redundancy pathway set was produced to represent global cellular systems. Enrichment analysis provides reliable functional annotations for each pathway node, attributing independent functions to pleiotropic genes. Edges are based on functional semantic similarity, generating a network representation of functional organisation. Both yeast and human biological systems are presented as functionally connected pathway networks. Pathway annotation and experimentation with semantic similarity measures provides insight into the cross-talk between biological processes. Pathway functional modules elucidate the intracellular implementation of processes. Disease modules highlight the effects of functional perturbations and disease mechanisms. The pathway model provides a complementary, high-level functional model that begins to bridge the gap between molecular data and phenotype. The utilisation of pathway data provides a large, well-validated data source, avoiding the inaccuracies inherent with molecular data. Pathway models better represent components of biological complexity such as pleiotropy and linear implementation of functions.
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Mendonca, Costa Javier. "Context-Aware Machine to Machine Communications in Cellular Networks." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-143180.

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Cellular network based Machine-to-Machine (M2M) communications have been growing rapidly in recent years, being used in a wide range of services such as security, metering, health, remote control, tracking and so on. A critical issue that needs to be considered in M2M communications is the energy efficiency, typically the machines are powered by batteries of low capacity and it is important to optimize the way the power is consumed. In search of better M2M systems, we propose a context-aware framework for M2M communications so the machine type communication (MTC) devices dynamically adapt their settings depending on a series of characteristics such as data reporting mode and quality of service (QoS) features so higher energy efficient is achieved, extending the operating lifetime of the M2M network. Simulations were performed with four commonly used M2M applications:home security, telehealth, climate and smart metering, achieving considerable energy savings and operating lifetime extension on the network. Thus, it is shown that contexts play an important role on the energy efficiency of a M2M system.
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Pernagallo, Salvatore. "Biocompatible polymer microarrays for cellular high-content screening." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/7571.

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The global aim of this thesis was to study the use of microarray technology for the screening and identification of biocompatible polymers, to understand physiological phenomena, and the design of biomaterials, implant surfaces and tissue-engineering scaffolds. This work was based upon the polymer microarray platform developed by the Bradley group. Polymer microarrays were successfully applied to find the best polymer supports for: (i) mouse fibroblast cells and used to evaluate cell biocompatibility and cell morphology. Fourteen polyurethanes demonstrated significant cellular adhesion. (ii) Analysis of the adhesion of human erythroleukaemic K562 suspension cells onto biomaterials with particular families of polyurethanes and polyacrylates identified. A DNA microarray study (to access the global gene expression profiles upon cellular binding) demonstrated that interactions between cells and some polyacrylates induced a number of transcriptomic changes. These results suggested that, during these interactions, a chain of cellular changes is triggered, most notably resulting in the downregulation of membrane receptors and ligands. (iii) Identification of polymers with potential applications in the field of stem cell biology. Polymers were identified that showed attachment, promotion and stabilisation of hepatocyte-like cells. A polyurethane support (PU-134) was pinpointed, which significantly improved both hepatocyte-like cell function and “lifespan”. A second project investigated biomaterials that promoted adhesion, growth and function of endothelial progenitor cells. A new polymer matrix was identified which contained the necessary signals to promote endothelial phenotype and function. This has potential application in the creation of blood vessels and the endothelialisation of artificial vessel prostheses and stent coatings for improving angioplasty therapy. (iv) The study of bacterial adhesion, focusing on the adhesion of food-borne pathogenic bacterium Salmonella enterica serovar typhimurium, strain SL1344, and the commensal bacterium Escherichia coli, strain W3110. Several polymers were found to support selective bacterial enrichment, as well as others that minimised bacterial adhesion.
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Laurin, David. "Maturation des cellules dendritiques en contexte allogénique et identification d'un antigène mineur d'histocompatibilité restreint par le CMH de classe II." Lyon 1, 2003. http://www.theses.fr/2003LYO1T220.

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La 4e de couverture indique : "Nous montrons, ici, que la réaction allogénique est capable d'activer les cellules dendritiques (DC) via la sécrétion de cytokines pro-inflammatoires. En effet, les peaux de patients atteints de maladie du greffon contre l'hôte (GvHD) n'ont plus de cellules de Langerhans dans l'épiderme et acquièrent l'expression de marqueurs des DC matures dans le derme. Ce résultat a été confirmé dans un modèle in vitro sur le plan phénotypique et fonctionnel. Les DC nous ont aussi permis de produire des clones T spécifiques d'un antigène mineur d'histocompatibilité lié au sexe (H-Y). Des lignées B-EBV-LCL transfectées par des gènes H-Y ou chargées par des peptides nous ont permis d'identifier le gène DBY et l'épitope restreints par HLA-DQB1*0501 ou HLA-DQB1*0502. Les clones T issus de deux fratries différentes utilisent un réarrangement du TCR qui présente d'importantes similitudes. Notre méthodologie pourrait favoriser la caractérisation d'antigènes immunodominants. Ces travaux présentent un intérêt dans les programmes de thérapie cellulaire et de greffes de cellules souches hématopoïétiques. "
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Laforce-Lavoie, Audrey. "Relation entre les cellules endothéliales microvasculaires et les myofibroblastes dans un contexte de cicatrisation cutanée normale et hypertrophique." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28393/28393.pdf.

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Severson, David T. "A study of the cellular and environmental context of Barrett's esophagus." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:088fe233-8b47-4ce5-aa84-6a74ddfa89d4.

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Barrett's esophagus is a pre-malignant lesion leading to esophageal adeno-carcinoma, where presence of Barrett's carries a seven fold increase in risk of developing cancer. The histology of Barrett's esophagus is diverse, containing squamous, gastric, and intestinal features, and the origin of the lesion is still under considerable debate. Professor Lu's research group aims to define the molecular features underlying the Barrett's lesion and elucidate the functional origin of the lesion. Because pathogens and commensals have previously been reported to be important in other cancers of the upper gastro-intestinal tract, we also aim to explore the role of microbes and viruses in Barrett's esophagus. We sequenced 3069 single cell RNA samples from endoscopic biopsies of the Barrett's lesion and relevant normal tissue in the upper gastro-intestinal tract and positive and negative controls. In order to draw meaningful conclusions from these single cell RNA data concerning the functional origin of Barrett's, we needed to identify robust relationships between single cell observations across tissue types. However, technical variance is a major confounding factor in single-cell RNA sequencing and could distort any such observed relationships. Therefore, I developed BEARscc, a tool that evaluates cluster robustness to noise by simulating experiment-specific technical replicates. I demonstrate that the tool improves the unsupervised classification of cells and aids the interpretation of single-cell RNA-seq experiments. I apply BEARscc to our single cell RNA-sequencing cohort and find striking similarity between the esophagus submucosal glandular ducts and a subset of Barrett's cells with undi erentiated characteristics. Using BEARscc, I also provide a robust description of the substructure of normal esophageal, gastric, and duodenal tissues. In order to characterize any microbial or viral presence in the microenvironment of Barrett's, I developed a pipeline, poshTitan, to identify pathogens and commensals in next generation sequencing data. I demonstrate that the poshTitan identifies pathogens with known associations in nasopharyngeal squamous cell carcinoma whole tissue RNA-sequencing and gastric adenocarcinoma whole genome sequencing data. I apply the poshTitan to whole tissue and single cell RNA-sequencing samples of Barrett's esophagus and normal controls and find no clear pattern of pathogen or commensal association with disease.
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Books on the topic "Cellular contexts"

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Washiyama, Miki. Studies on the cellular contents of human germinal centres. Birmingham: University of Birmingham, 1995.

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DuBois, Marc L. Action potential: Biophysical and cellular context, initiation, phases, and propagation. New York: Nova Science, 2010.

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Zucker, Jonny. Spin Off. Mankato: Stone Arch Books, 2007.

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Reissner, Kathryn J., and Peter W. Kalivas. Cellular and Molecular Mechanisms of Addiction. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0046.

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Exposure to drugs of abuse can be a reinforcing experience that, in vulnerable individuals, can lead to continued use and the development of an addiction disorder. Evidence indicates that the escalation in use and compulsive motivation to obtain the drug is linked to long-lasting cellular changes within the brain reward neurocircuitry. In this chapter we describe the stages of transition in use from social use to habitual relapse, and within that context we describe the implicated neurocircuitry, and the enduring cellular and molecular changes that occur within that circuitry, that may mediate the preoccupation with drug seeking in addiction-vulnerable individuals.
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Aliev, Gjumrakch. Role of Oxidative Stress, Mitochondria Failure, and Cellular Hypoperfusion in the Context of Alzheimer Disease: Past, Present and Future. Nova Science Publishers, Incorporated, 2013.

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Benedito, Rui, and Arndt F. Siekmann. Blood vessel differentiation and growth. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0016.

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A variety of diseases are related to or dependent on the vascular system. Several lines of evidence show that adequate manipulation of the vascular function in disease requires targeting and interfering with the same molecular pathways and cellular processes that act to form vessels during embryo or organ development. Therefore an understanding of the mechanisms that regulate vascular development in this non-pathological context is of major importance, since it may lead to better ways of treating vascular-related pathologies. This chapter covers the most significant cellular and molecular mechanisms involved in the origin, life, and death of the endothelial cellwhich is involved in several important developmental and pathological processes. Most of the mechanisms described were identified in animal model systems. However, owing to the high evolutionary conservation of these, they are likely be very similar to those occurring in humans and in disease.
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Cianni, Juliana. Uma aventura pela respiração celular. Brazil Publishing, 2021. http://dx.doi.org/10.31012/978-65-5861-454-8.

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The story contained in this book is the result of my inquiries as a teacher and as a student looking for an easier and more fun way to learn dense content from the disciplines contained in the so beautiful universe of Sciences. I believe that pleasurable and consistent learning is possible, if we have a little bit of imagination and a powder of pimpimpimpim, allowing the student to be enchanted with the mysteries of life, a life that pulsates in the macro and microcosm. So, one fine day, watching Professor Rita's Biotechnology class at USP in Lorena / SP, I asked myself: why not facilitate the high school content that is charged in entrance exams and turn them into something playful and made it easier for students to have more effective access to deeper knowledge of science? It was with this objective that this little book was born that, in addition to offering a new experience about cellular respiration, also offers some excerpts from books that have always enchanted my eyes and touched my heart. Thus, more than an adventure through cellular respiration, this book proposes an adventure for the human spirit itself, that everything can and is capable, reminding us that the material world is intrinsically linked to the world of ideas, the first being nothing more it is more than an adventure of the human spirit itself.
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Plutynski, Anya. Causation, Causal Selection, and Causal Parity. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199967452.003.0004.

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It is typical to refer to cancer as a “genetic” or “genomic” disease. This claim is ambiguous; one of the central goals of this chapter is to disambiguate this claim. I first distinguish different types of causal claims: claims about causal relevance, causal role, and causal specificity. As a backdrop to this discussion, I introduce what I call the “mechanistic research program” in cancer, according to which progression to cancer involves breakdowns in regulatory controls on gene expression in ways that affect cell birth and death. While this research program has been successful, it has downplayed the role of context in cancer progression, and the fact that disorderly cellular growth is affected by many pathways. I conclude by considering several philosophers’ accounts of “causal selection” and argue that ultimately the causal selection problem is not one but several different problems, requiring different, context-specific solutions.
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Zucker, Jonny. Spin Off (Rex Jones). Stone Arch Books, 2007.

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Dyer, Laura A., and Margaret L. Kirby. The role of the neural crest in cardiac development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0019.

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The cardiac neural crest (CNC) plays pivotal roles in numerous steps of cardiac development. Every aspect of the CNC cell’s lifespan is highly orchestrated, from its induction in the dorsal neural tube to its migration to its differentiation at its final destination. During migration, CNC cells are affected by their environment and simultaneously modulate the extra-cellular milieu through which they migrate. In the pharyngeal arches, CNC cells repattern the originally symmetrical arch arteries, producing the great arteries. Because the cardiac neural crest is essential for many aspects of heart development, it is unsurprising that human CNC-related syndromes have severe phenotypes. This chapter describes how CNC cells are formed and contribute to their final destinations. Essential signalling pathways are presented in the context of CNC development, and CNC-related syndromes are included to highlight this population’s broad importance during development.
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Book chapters on the topic "Cellular contexts"

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Gershan, Richard K., and Tomio Tada. "Contexts in the cellular communications: How the mobile cells recognize right partner cells to talk with?" In The Semiotics of Cellular Communication in the Immune System, 83–104. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73145-7_9.

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Kutrib, Martin. "Nature-Based Problems in Cellular Automata." In Models of Computation in Context, 171–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21875-0_18.

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Lathrop, James I., Jack H. Lutz, and Brian Patterson. "Multi-Resolution Cellular Automata for Real Computation." In Models of Computation in Context, 181–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21875-0_19.

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Flaumenhaft, Robert, and Secil Koseoglu. "Platelet Contents." In Molecular and Cellular Biology of Platelet Formation, 133–52. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-39562-3_6.

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Peña-Cantillana, Francisco, Ainhoa Berciano, Daniel Díaz-Pernil, and Miguel A. Gutiérrez-Naranjo. "Parallel Skeletonizing of Digital Images by Using Cellular Automata." In Computational Topology in Image Context, 39–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-30238-1_5.

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Arrighi, Pablo, Renan Fargetton, Vincent Nesme, and Eric Thierry. "Applying Causality Principles to the Axiomatization of Probabilistic Cellular Automata." In Models of Computation in Context, 1–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21875-0_1.

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Forte, Michael. "VDAC function in a cellular context." In Mitochondrial Function and Biogenesis, 251–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b97158.

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Li, Zhenhua, Yafei Dai, Guihai Chen, and Yunhao Liu. "Cross-Application Cellular Traffic Optimization." In Content Distribution for Mobile Internet: A Cloud-based Approach, 19–48. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-1463-5_2.

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Mutabazi, Innocent, José Eduardo Wesfreid, and Etienne Guyon. "The Context of Bénard Scientific Work and Nonlinear Science." In Dynamics of Spatio-Temporal Cellular Structures, 3–8. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-25111-0_1.

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Terrier, Véronique. "Recognition of Linear-Slender Context-Free Languages by Real Time One-Way Cellular Automata." In Cellular Automata and Discrete Complex Systems, 251–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47221-7_19.

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Conference papers on the topic "Cellular contexts"

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Tembe, Waibhav, Shaoyan Zhang, Siddharth Raghavan, James Lowey, Seungchan Kim, and Edward Suh. "Parallel programming to identify cellular contexts." In 2008 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS). IEEE, 2008. http://dx.doi.org/10.1109/gensips.2008.4555658.

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Iyengar, Srinivasan, Vijay K. Gurbani, Yu Zhou, and Sameerkumar Sharma. "Opportunistic Prefetching of Cellular Internet of Things (cIoT) Device Contexts." In 2018 27th International Conference on Computer Communication and Networks (ICCCN). IEEE, 2018. http://dx.doi.org/10.1109/icccn.2018.8487456.

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Liang, Huiguang, Ido Nevat, Hyong S. Kim, Hwee-Pink Tan, and Wai-Leong Yeow. "Not you too? Distilling local contexts of poor cellular network performance through participatory sensing." In NOMS 2016 - 2016 IEEE/IFIP Network Operations and Management Symposium. IEEE, 2016. http://dx.doi.org/10.1109/noms.2016.7502836.

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Xiao, Zhan, Rosa A. Carrasco, Krista Kinneer, Darrin Sabol, Steve Coats, Bahija Jallal, and David Tice. "Abstract 307: EphB4 promotes or suppresses Ras/ERK pathway depending on cellular contexts: Implications for EphB4 as a cancer target." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-307.

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Lungaro, Pietro, Zary Segall, and Jens Zander. "Context-Aware RRM for Opportunistic Content Delivery in Cellular Networks." In 2010 Third International Conference on Communication Theory, Reliability, and Quality of Service. IEEE, 2010. http://dx.doi.org/10.1109/ctrq.2010.37.

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Lungaro, Pietro, Zary Segall, and Jens Zander. "Predictive and Context-Aware Multimedia Content Delivery for Future Cellular Networks." In 2010 IEEE 71st Vehicular Technology Conference. IEEE, 2010. http://dx.doi.org/10.1109/vetecs.2010.5493664.

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"Table of contents." In 2005 9th International Workshop on Cellular Neural Networks and Their Applications. IEEE, 2005. http://dx.doi.org/10.1109/cnna.2005.1543145.

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"Table of Contents." In 2006 10th International Workshop on Cellular Neural Networks and Their Applications. IEEE, 2006. http://dx.doi.org/10.1109/cnna.2006.341583.

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Coll-Perales, Baldomero, and Javier Gozalvez. "Content- and context-aware opportunistic cellular communications in device-centric wireless networks." In 2016 IEEE 27th Annual International Symposium on Personal, Indoor, and Mobile Radio Communications (PIMRC). IEEE, 2016. http://dx.doi.org/10.1109/pimrc.2016.7794852.

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"CNNA 2008- Table of contents." In 2008 11th International Workshop on Cellular Neural Networks and Their Applications. IEEE, 2008. http://dx.doi.org/10.1109/cnna.2008.4588631.

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Reports on the topic "Cellular contexts"

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Morphett, Jane, Alexandra Whittaker, Amy Reichelt, and Mark Hutchinson. Perineuronal net structure as a non-cellular mechanism of affective state, a scoping review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0075.

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Is the perineuronal net structure within emotional processing brain regions associated with changes in affective state? The objective of this scoping review is to bring together the literature on human and animal studies which have measured perineuronal net structure in brain regions associated with emotional processing (such as but not limited to amygdala, hippocampus and prefrontal cortex). Perineuronal nets are a specialised form of condensed extracellular matrix that enwrap and protect neurons (Suttkus et al., 2016), regulate synaptic plasticity (Celio and Blumcke, 1994) and ion homeostasis (Morawski et al., 2015). Perineuronal nets are dynamic structures that are influenced by external and internal environmental shifts – for example, increasing in intensity and number in response to stressors (Blanco and Conant, 2021) and pharmacological agents (Riga et al., 2017). This review’s objective is to generate a compilation of existing knowledge regarding the structural changes of perineuronal nets in experimental studies that manipulate affective state, including those that alter environmental stressors. The outcomes will inform future research directions by elucidating non-cellular central nervous system mechanisms that underpin positive and negative emotional states. These methods may also be targets for manipulation to manage conditions of depression or promote wellbeing. Population: human and animal Condition: affective state as determined through validated behavioural assessment methods or established biomarkers. This includes both positive and negative affective states. Context: PNN structure, measuringPNNs.
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Jones, Robert M., Alison K. Thurston, Robyn A. Barbato, and Eftihia V. Barnes. Evaluating the Conductive Properties of Melanin-Producing Fungus, Curvularia lunata, after Copper Doping. Engineer Research and Development Center (U.S.), November 2020. http://dx.doi.org/10.21079/11681/38641.

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Melanins are pigmented biomacromolecules found throughout all domains of life. Of melanins’ many unique properties, their malleable electrically conductive properties and their ability to chelate could allow them to serve as material for bioelectronics. Studies have shown that sheets or pellets of melanin conduct low levels of electricity; however, electrical conductance of melanin within a cellular context has not been thoroughly investigated. In addition, given the chelating properties of melanin, it is possible that introducing traditionally con-ductive metal ions could improve the conductivity. Therefore, this study investigated the conductive properties of melanized cells and how metal ions change these. We measured the con-ductivity of pulverized Curvularia lunata, a melanized filamentous fungi, with and without the addition of copper ions. We then com-pared the conductivity measurements of the fungus to chemically synthesized, commercially bought melanin. Our data showed that the conductivity of the melanized fungal biomass was an order of magnitude higher when grown in the presence of copper. However, it was two orders of magnitude less than that of synthetic melanin. Interestingly, conductance was measurable despite additional constituents in the pellet that may inhibit conductivity. Therefore, these data show promising results for using melanized cells to carry electrical signals.
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