Relevant bibliographies by topics / Cellular fibers

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cellular fibers'

Author: Grafiati
Published: 30 May 2022
Last updated: 31 May 2022

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Journal articles on the topic "Cellular fibers"

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Powers, S. K., D. Criswell, F. K. Lieu, S. Dodd, and H. Silverman. "Exercise-induced cellular alterations in the diaphragm." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 263, no. 5 (1992): R1093—R1098. http://dx.doi.org/10.1152/ajpregu.1992.263.5.r1093.

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Limited data exist concerning the effects of exercise training on cellular oxidative capacity in the diaphragm of senescent animals. In this study we examined the changes in cellular oxidative capacity, muscle cell cross-sectional area (CSA), and capillarity within the costal diaphragm of senescent animals after a 10-wk endurance-training program. Twelve 24-mo-old female Fischer 344 rats were divided into either a sedentary control group (n = 6) or exercise training group (n = 6). The trained animals exercised on a motor-driven treadmill (60 min/day, 5 days/wk) at a work rate equal to approximately 55-65% VO2max. Capillaries were identified histologically and fiber types determined using adenosinetriphosphatase (ATPase) histochemistry. Succinate dehydrogenase (SDH) activity and CSA in individual fibers were measured using a computerized image analysis system. Exercise training did not increase (P > 0.05) the capillary-to-fiber ratio for any fiber type. However, training significantly decreased CSA (P < 0.05) and increased capillary density (capillary number/CSA) (P < 0.05) in type I, type IIa, and type IIb fibers. Furthermore, exercise training resulted in small but significant increase in SDH activity (P < 0.05) in type I and IIa fibers, whereas training did not alter SDH activity (P > 0.05) in type IIb fibers. These data demonstrate that endurance training in senescent animals results in small relative improvements in both oxidative capacity and capillary density in costal diaphragmatic type I and IIa muscle fibers. The increase in both capillary density and fiber SDH activity was largely due to a reduction in fiber CSA.
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Netsvet, Daria Dmitrievna, Alexandr L. Popov, Viktoriya Viktorovna Nelubova, and Svetlana V. Lasunova. "Properties of Microfibers of Various Compositions as a Component of Cellular Composites." Materials Science Forum 1040 (July 27, 2021): 132–38. http://dx.doi.org/10.4028/www.scientific.net/msf.1040.132.

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The paper presents studies on the properties of various types of micro-reinforcing fibers to assess their role and effectiveness in the structure formation of the cellular composite. Based on the data on the weight loss after exposure in a model medium of cement, analysis of the alkali resistance of fibers of five different types – basalt fiber, heat-treated basalt fiber, polymer fiber and glass fibers from two different manufacturers – was carried out. It is shown that the fibers have a sufficiently high durability in the medium of hardening cement, which is expressed by a relatively insignificant weight loss of the original fiber after exposure in a model medium for 28 days in ambient conditions. The weight loss for some fibers sharply increases when hardening conditions are changed to hydrothermal ones. The images of fibers exposed in a model medium of cement, obtained using scanning microscopy, were also analyzed, and the character of distribution of acidic and basic adsorption sites on the surface of fibers depending on the type was assessed. Based on the analysis of the obtained data, we can talk about a high number of active sites on the surface of basalt and glass fibers, which ensures the formation of crystalline new formations on them and makes it possible to predict their high adhesion to the cement matrix.
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Hardy, Kristin M., Richard M. Dillaman, Bruce R. Locke, and Stephen T. Kinsey. "A skeletal muscle model of extreme hypertrophic growth reveals the influence of diffusion on cellular design." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 6 (2009): R1855—R1867. http://dx.doi.org/10.1152/ajpregu.00076.2009.

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Muscle fibers that power swimming in the blue crab Callinectes sapidus are <80 μm in diameter in juveniles but grow hypertrophically, exceeding 600 μm in adults. Therefore, intracellular diffusion distances become progressively greater as the animals grow and, in adults, vastly exceed those in most cells. This developmental trajectory makes C. sapidus an excellent model for characterization of the influence of diffusion on fiber structure. The anaerobic light fibers, which power burst swimming, undergo a prominent shift in organelle distribution with growth. Mitochondria, which require O2 and rely on the transport of small, rapidly diffusing metabolites, are evenly distributed throughout the small fibers of juveniles, but in the large fibers of adults they are located almost exclusively at the fiber periphery where O2 concentrations are high. Nuclei, which do not require O2, but rely on the transport of large, slow-moving macromolecules, have the inverse pattern: they are distributed peripherally in small fibers but are evenly distributed across the large fibers, thereby reducing diffusion path lengths for large macromolecules. The aerobic dark fibers, which power endurance swimming, have evolved an intricate network of cytoplasmically isolated, highly perfused subdivisions that create the short diffusion distances needed to meet the high aerobic ATP turnover demands of sustained contraction. However, fiber innervation patterns are the same in the dark and light fibers. Thus the dark fibers appear to have disparate functional units for metabolism (fiber subdivision) and contraction (entire fiber). Reaction-diffusion mathematical models demonstrate that diffusion would greatly constrain the rate of metabolic processes without these developmental changes in fiber structure.
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Luden, Nicholas, Kiril Minchev, Erik Hayes, Emily Louis, Todd Trappe, and Scott Trappe. "Human vastus lateralis and soleus muscles display divergent cellular contractile properties." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 5 (2008): R1593—R1598. http://dx.doi.org/10.1152/ajpregu.90564.2008.

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The purpose of this study was to investigate potential differences in single-fiber contractile physiology of fibers with the same myosin heavy chain isoform (MHC I and MHC IIa) originating from different muscles. Vastus lateralis (VL) and soleus biopsies were obtained from 27 recreationally active females (31 ± 1 yr, 59 ± 1 kg). A total of 943 single fibers (MHC I = 562; MHC IIa = 301) were isolated and examined for diameter, peak tension (Po), shortening velocity (Vo), and power. The soleus had larger ( P < 0.05) fibers (MHC I +18%; MHC IIa +19%), higher MHC I Vo (+13%), and higher MHC I Po (+18%) compared with fibers from the VL. In contrast, fibers from the VL had higher ( P < 0.05) specific tension (MHC I +18%; MHC IIa +20%), and MHC I normalized power (+25%) compared with the soleus. There was a trend for MHC IIa soleus fibers to have higher Vo [MHC IIa +13% ( P = 0.058)], whereas VL MHC IIa fibers showed a trend for higher normalized power compared with soleus fibers [MHC IIa +33% ( P = 0.079)]. No differences in absolute power were detected between muscles. These data highlight muscle-specific differences in single-fiber contractile function that should serve as a scientific basis for consideration when extending observations of skeletal muscle tissue from one muscle of interest to other muscles of origin. This is important when examining skeletal muscle adaptation to physical states such as aging, unloading, and training.
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Hassan Nensok, Mohammed, Md Azree Othuman Mydin, and Hanizam Awang. "Optimization of mechanical properties of cellular lightweight concrete with alkali treated banana fiber." Revista de la construcción 20, no. 3 (2021): 491–511. http://dx.doi.org/10.7764/rdlc.20.3.491.

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Recent advancements in construction materials development have involved the utilization of plant-based natural fibers such as kenaf, sisal, coir and banana to replace conventional fibers such as carbon, steel, polypropylene and aramid. However, the main issue with using these fibers is the alkaline cement matrix's durability and compatibility due to high water absorption. Hence, this research focuses on the use of alkali treatment of banana fibers to enhance the mechanical properties of cellular lightweight concrete (CLC). Banana fibers were subjected to 2%, 4%, 6%, 8%, and 10% NaOH treatment before being included in 1200 kg/m3 density CLC. Plain CLC and untreated fiber composites (0% NaOH treatment) were used as the control. Results from the study indicate that compared to the untreated fibre composites and plain control CLC at 28 days, compressive, flexural and splitting tensile strengths increased simultaneously with 6% NaOH fibre treatment to peaks of 40.6% and 59.8%, 63.8% and 117.4%, and 77.4% and 157.8% respectively. The 6% NaOH treatment of BF tremendously improved the mechanical characteristics of single fibers and BFRCLC composites. It is therefore concluded that 6% NaOH treatment of banana fibre was the optimum percentage alkali treatment for use in CLC.
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Lin, Ling, Yun Neng Chen, Wen Zhong Gong, and Shan Yuan Wang. "Antibacterial Efficiency and Cellular Toxicity of PET-Based Hollow Fibers Containing Silver Particles." Advanced Materials Research 441 (January 2012): 279–83. http://dx.doi.org/10.4028/www.scientific.net/amr.441.279.

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This work focuses on antibacterial efficacy and cellular toxicity of PET-based hollow fiber with silver particles incorporated (Ag/PET hollow fiber), which was synthesized by differential pressure method. Escherichia coli (E. coli) were used to investigate the antibacterial capability of Ag/PET hollow fiber with antibacterial kinetics experiments. The antibacterial results demonstrated that Ag/PET hollow fiber had an excellent antibacterial property against E. coli and the efficacy was dependent on several aspects including fiber length, weight and silver content. The cytotoxicity of Ag/PET hollow fibers on WI-38 cells was assessed using Methyl Thiazolyl Tetrazolium (MTT) assay, and the results showed no significant toxicity to WI-38 cells. SEM images of WI-38 cells treated by Ag/PET hollow fibers showed that cells morphology was unaltered in the presence of Ag/PET hollow fiber. However, abnormal size, shrinkage and rounded appearance of cells at higher dose suggested slight toxicity of Ag/PET hollow fiber. Combining the antibacterial and cytotoxic results, it was found that there was a certain concentration of silver ions which can achieve a minimization of cytotoxicity and a maximization of antibacterial efficacy.
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Rajan, Anandi, Elin Palm, Fredrik Trulsson, et al. "Heparan Sulfate Is a Cellular Receptor for Enteric Human Adenoviruses." Viruses 13, no. 2 (2021): 298. http://dx.doi.org/10.3390/v13020298.

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Human adenovirus (HAdV)-F40 and -F41 are leading causes of diarrhea and diarrhea-associated mortality in children under the age of five, but the mechanisms by which they infect host cells are poorly understood. HAdVs initiate infection through interactions between the knob domain of the fiber capsid protein and host cell receptors. Unlike most other HAdVs, HAdV-F40 and -F41 possess two different fiber proteins—a long fiber and a short fiber. Whereas the long fiber binds to the Coxsackievirus and adenovirus receptor (CAR), no binding partners have been identified for the short fiber. In this study, we identified heparan sulfate (HS) as an interaction partner for the short fiber of enteric HAdVs. We demonstrate that exposure to acidic pH, which mimics the environment of the stomach, inactivates the interaction of enteric adenovirus with CAR. However, the short fiber:HS interaction is resistant to and even enhanced by acidic pH, which allows attachment to host cells. Our results suggest a switch in receptor usage of enteric HAdVs after exposure to acidic pH and add to the understanding of the function of the short fibers. These results may also be useful for antiviral drug development and the utilization of enteric HAdVs for clinical applications such as vaccine development.
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Straight, Chad R., Olivia R. Ringham, Jenna M. Bartley, et al. "Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice." Journals of Gerontology: Series A 75, no. 12 (2020): 2333–41. http://dx.doi.org/10.1093/gerona/glaa136.

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Abstract Skeletal muscle myopathies represent a common non-pulmonary manifestation of influenza infection, leading to reduced physical function and hospitalization in older adults. However, underlying mechanisms remain poorly understood. Our study examined the effects of influenza virus A pulmonary infection on contractile function at the cellular (single fiber) and molecular (myosin-actin interactions and myofilament properties) levels in soleus and extensor digitorum longus muscles of aged (20 months) C57BL/6 male mice that were healthy or flu-infected for 7 (7-days post-infection; 7-DPI) or 12 days (12-DPI). Cross-sectional area (CSA) of myosin heavy chain (MHC) IIA and IIB fibers was reduced at 12-DPI relative to 7-DPI and healthy. Maximal isometric force in MHC IIA fibers was also reduced at 12-DPI relative to 7-DPI and healthy, resulting in no change in specific force (maximal isometric force divided by CSA). In contrast, MHC IIB fibers produced greater isometric force and specific force at 7-DPI compared to 12-DPI or healthy. The increased specific force in MHC IIB fibers was likely due to greater myofilament lattice stiffness and/or an increased number or stiffness of strongly bound myosin-actin cross-bridges. At the molecular level, cross-bridge kinetics were slower in MHC IIA fibers with infection, while changes in MHC IIB fibers were largely absent. In both fiber types, greater myofilament lattice stiffness was positively related to specific force. This study provides novel evidence that cellular and molecular contractile function is impacted by influenza infection in a fiber type-specific manner, suggesting potential molecular mechanisms to help explain the impact of flu-induced myopathies.
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Biring, Manmohan S., Mario Fournier, David J. Ross, and Michael I. Lewis. "Cellular adaptations of skeletal muscles to cyclosporine." Journal of Applied Physiology 84, no. 6 (1998): 1967–75. http://dx.doi.org/10.1152/jappl.1998.84.6.1967.

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The aim of this study was to evaluate the cellular response of the diaphragm, extensor digitorum longus (EDL), and soleus (Sol) muscles to clinically relevant doses of cyclosporine administered to male rats over 4 wk. Control rats were provided with vehicle only. Muscle fiber types, cross-sectional areas, indexes of capillarity, and succinate dehydrogenase (SDH) activity were determined by quantitative histochemistry. Myosin heavy chain isoforms were identified by SDS-PAGE, and their proportions were measured by scanning densitometry. Serum cyclosporine level, 20–24 h after the last dose of cyclosporine, was 145 ± 81 ng/ml. Final body weight and muscle mass were similar between the cyclosporine and control groups. In the diaphragm, EDL, and Sol, no differences were observed between the groups with regard to fiber type proportions, fiber cross-sectional areas, and proportions of myosin heavy chain isoforms. In the EDL, reductions, both in SDH activity in type I, IIx, and IIb fibers (−26 to −37%) and in indexes of capillarity (−18 to −37%), were noted. In the Sol, SDH activity and capillarity were similar between the groups. In the diaphragm of cyclosporine-treated rats, there was significant reduction in the number of capillaries around individual fibers (−5%), whereas levels of SDH activity tended to be lower. This suggests that activation history may in part determine muscle-specific responses to cyclosporine. We speculate that reduced oxidative activity and capillarity of some limb muscles contribute to reduced exercise capacity and the “deconditioned state” observed in patients receiving cyclosporine after successful solid-organ transplantation.
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Larkins, Noni T., Robyn M. Murphy та Graham D. Lamb. "Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat". American Journal of Physiology-Cell Physiology 302, № 1 (2012): C228—C239. http://dx.doi.org/10.1152/ajpcell.00266.2011.

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Heat shock proteins (HSPs) are essential for normal cellular stress responses. Absolute amounts of HSP72, HSP25, and αB-crystallin in rat extensor digitorum longus (EDL) and soleus (SOL) muscle were ascertained by quantitative Western blotting to better understand their respective capabilities and limitations. HSP72 content of EDL and SOL muscle was only ∼1.1 and 4.6 μmol/kg wet wt, respectively, and HSP25 content approximately twofold greater (∼3.4 and ∼8.9 μmol/kg, respectively). αB-crystallin content of EDL muscle was ∼4.9 μmol/kg but in SOL muscle was ∼30-fold higher (∼140 μmol/kg). To examine fiber heterogeneity, HSP content was also assessed in individual fiber segments; every EDL type II fiber had less of each HSP than any SOL type I fiber, whereas the two SOL type II fibers examined were indistinguishable from the EDL type II fibers. Sarcolemma removal (fiber skinning) demonstrated that 10–20% of HSP25 and αB-crystallin was sarcolemma-associated in SOL fibers. HSP diffusibility was assessed from the extent and rate of diffusion out of skinned fiber segments. In unstressed SOL fibers, 70–90% of each HSP was readily diffusible, whereas ∼95% remained tightly bound in fibers from SOL muscles heated to 45°C. Membrane disruption with Triton X-100 allowed dispersion of HSP72 and sarco(endo)plasmic reticulum Ca2+-ATPase pumps but did not alter binding of HSP25 or αB-crystallin. The amount of HSP72 in unstressed EDL muscle is much less than the number of its putative binding sites, whereas SOL type I fibers contain large amounts of αB-crystallin, suggesting its importance in normal cellular function without upregulation.
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Dissertations / Theses on the topic "Cellular fibers"

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Roth, David Eugene. "Genetic Engineering of Functional Large Amyloid Fibers." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/78399.

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"Template" and "adder" proteins can be genetically encoded to produce large amyloid fibers when mixed together. Escherichia coli is used to clone a "template" protein, Gd20, which will cooperatively self-assemble with two "adder" proteins, P7Q and P7S, to yield two different large amyloid fibers. Atomic force microscopy (AFM) is used to image the fibers and AFM tip approach/retraction force is used to quantify molecular packing in the fibers. Glutamine (Q)-containing P7Q and serine (S)-containing P7S both have the same hydrophobic core, charge, and hydrogen bonding potential. However, P7Q is highly alpha-helical while P7S contains a beta-sheet core. After 72 hours, the Gd20:P7Q template:adder protein mixture produces tightly packed ~0.3 μm high and ~1.9 μm wide fibers that exhibit a low retraction force of ~44 nN after indentation. The Gd20:P7S mixture produces larger ~1.1 μm high and ~9.7 μm wide fibers exhibiting a much higher retraction force of ~503 nN showing they are much less molecularly packed. These results indicate that the adder protein alpha-helical character is important for self-assembly and molecular packing inside of the large amyloid fiber. The experimental results show that large amyloid fibers with predictable size and mechanical properties can be anticipated and encoded at the genetic level.<br>Master of Science
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Ledbetter, Nicole Verbeck Guido F. "Applications of nanomanipulation coupled to nanospray mass spectrometry in trace fiber analysis and cellular lipid analysis." [Denton, Tex.] : University of North Texas, 2008. http://digital.library.unt.edu/permalink/meta-dc-9760.

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Nelson, Mark Tyler. "Biomimetic Electrospun Fibers for Cancer Cell Migration, Chemotaxis, andAnti-Metastatic Drug Testing." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429031970.

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Ledbetter, Nicole. "Applications of Nanomanipulation Coupled to Nanospray Mass Spectrometry in Trace Fiber Analysis and Cellular Lipid Analysis." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9760/.

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The novel instrumentation of nanomanipulation coupled to nanospray mass spectrometry and its applications are presented. The nanomanipulator has the resolution of 10nm step sizes allowing for specific fine movement used to probe and characterize objects of interest. Nanospray mass spectrometry only needs a minimum sample volume of 300nl and a minimum sample size of 300attograms to analyze an analyte making it the ideal instrument to couple to nanomanipulation. The nanomanipulator is mounted to an inverted microscope and consists of 4 nano-positioners; these nano-positioners hold end-effectors and other tools used for manipulation. This original coupling has been used to enhance the current abilities of cellular probing and trace fiber analysis. Experiments have been performed to demonstrate the functionality of this instrument and its capabilities. Histidine and caffeine have been sampled directly from single fibers and analyzed. Lipid bodies from cotton seeds have been sampled indirectly and analyzed. The few applications demonstrated are only the beginning of nanomanipulation coupled to nanospray mass spectrometry and the possible applications are numerous especially with the ability to design and fabricate new end-effectors with unique abilities. Future study will be done to further the applications in direct cellular probing including toxicology studies and organelle analysis of single cells. Further studies will be directed in forensic applications of this instrument including gunshot residue sampled from fibers.
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Badauy, Cristiano Macabú. "Avaliação estrutural e diagnóstica de três lesões fibrosas da cavidade bucal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/15449.

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O objetivo do presente trabalho é analisar os componentes celulares e de fibras do tecido conjuntivo nas hiperplasias inflamatórias (HI), nos fibromas (F) e na fibromatose gengival hereditária (FGH), além de investigar a imunocompetência e efetuar análises moleculares de pacientes com FGH. Para atingir os objetivos foram desenvolvidos 4 artigos, com diferentes metodologias e universos amostrais. No 1º artigo, pretendeu-se estabelecer critérios microscópicos válidos para diferenciar F e HI. Foram avaliadas em microscópio óptico 136 lesões coradas pela Hematoxilina-eosina (HE) e pelo Tricrômico de Masson quanto às características microscópicas. Os resultados mostraram que uma área central de fibras colágenas dispostas de forma enovelada e mais densa, circundada por uma camada de fibras dispostas de forma paralela são características dos F, enquanto a presença de hiperplasia epitelial, infiltrado inflamatório e fibras colágenas organizadas de forma paralela são características das HI. Tais resultados motivaram o 2º artigo, no qual estudamos 18 lesões de F e 13 de HI, que foram preparadas histologicamente e coradas pelo picrosírius red e pelo direct blue para avaliação quantitativa das fibras colágenas e de fibras do sistema elástico, respectivamente, em microscopia a laser confocal. Os resultados confirmaram a disposição estrutural das fibras colágenas observada no 1º artigo, além de apontarem diferenças nas áreas ocupadas pelas fibras colágenas em todas as regiões estudadas. A fim de proceder a uma avaliação dos componentes fibroso e celular das 3 lesões fibrosas, foi desenvolvido o 3º artigo. Espécimes das 3 lesões foram estudados em microscopia ótica, a fim de avaliar suas populações de fibroblastos e de células inflamatórias e os seguintes componentes fibrosos do tecido conjuntivo: fibras colágenas, sistema de fibras elásticas, fibras reticulares e fibras oxitalânicas. Os resultados mostraram disposição e concentração diferente das fibras colágenas nas 3 lesões e uma maior concentração de fibras reticulares na FGH. A análise dos componentes celulares mostrou um maior número de fibroblastos no F e uma maior contagem de células inflamatórias na HI. A partir do encaminhamento de uma família com FGH, optouse por inclui-la no estudo, tendo em vista serem lesões do mesmo grupo. Com isso, foi desenvolvido um 4º estudo, que utilizou uma avaliação morfológica semelhante à dos 2 artigos anteriormente descritos. Dos pacientes com FGH foi obtido sangue periférico para avaliação da proliferação celular de linfócitos através do teste do MTT e para o sequenciamento do gene SOS-1. Os resultados mostraram hiperplasia epitelial na porção externa da gengiva dos pacientes com FGH, maior concentração de fibras colágenas e poucas células inflamatórias. Os 3 pacientes com FGH não mostraram diferenças no seu índice de proliferação de linfócitos em relação aos controles e não apresentaram a mutação descrita no gene SOS-1 de outras famílias com FGH. Pode se concluir que as 3 lesões apresentam estrutura conjuntiva diferente tanto no aspecto quantitativo quanto na disposição estrutural de seus componentes.<br>The objective of this study was to analyze the cellular and fibrous components of connective tissue in inflammatory hyperplasia (IH), oral fibroma (OF) and hereditary gingival fibromatosis (HGF), and to investigate the immunocompetence and to perform molecular analysis in HGF patients. To achieve the goals were developed 4 articles, with different methodologies and sample universes. In the 1st article, we intended to establish microscopic criteria to differentiate F and IH. The microscopic characteristics of the lesions (n=136) stained by hematoxylin-eosin (HE) and Masson trichrome were evaluated in an optical microscope. The results showed that a central area of wound collagen fibers and arranged in a higher density, surrounded by a layer of parallel fibers are characteristic of F, while the presence of epithelial hyperplasia, inflammatory infiltrate and parallel collagen fibers are characteristics of HI. These results led the 2nd article, which studied 18 F and 13 and IH, histologically prepared and stained by picrosírius red and direct blue for the direct quantitative assessment of collagen fibers and elastic fibers of the system, respectively, in the confocal laser microscope. The results confirmed the structural arrangement of collagen fibers found in Article 1, and indicate differences in the areas of collagen fibers in all regions studied. In order to evaluate the cellular and fibrous components of the 3 fibrous lesions, was developed the 3rd article. Specimens of the 3 lesions were studied in optical microscopy, to assess their populations of fibroblasts and inflammatory cells and the following components of fibrous connective tissue: collagen fibers, elastic fiber system, reticular fibers and oxytalan fibers. The results showed different arrangement and concentration of collagen fibers in the 3 lesions and a higher concentration of reticular fibers in HGF. The analysis of cellular components showed a greater number of fibroblasts in F and a higher count of inflammatory cells in IH. With the identification of a family with HGF, we chose to include it in the study because the lesions belong to the group of benign fibrous lesions. With that, it developed a 4th study, which used a similar morphologic evaluation of the 2 articles described above. Periferic blood was extracted from the HGF patients in order to determine the proliferative capacity of the peripheral lymphocytes, by the MTT test, and in order to sequence the SOS1 gene. The 3 HGF affected patients did not present the described mutation for the SOS1 gene, and the lymphocyte proliferative capacity in HGF patients was similar to those on controls. The results showed epithelial hyperplasia in the outer portion of the gingiva of patients with HGF, greater concentration of collagen fibers and few inflammatory cells. We can conclude that the 3 lesions present a different connective structure, considering both the quantitative aspect and the architectural disposition of their components.
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Griebel, Matthew Alexander. "Viscoelastic Anisotropic Finite Element Mixture Model of Articular Cartilage using Viscoelastic Collagen Fibers and Validation with Stress Relaxation Data." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/743.

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Experimental results show that collagen fibers exhibit stress relaxation under tension and a highly anisotropic distribution. To further develop the earlier model of Stender [1], the collagen constituent was updated to reflect its intrinsic viscoelasticity and anisotropic distribution, and integrated with an existing mixture model with glycosaminoglycans and ground substance matrix. A two-term Prony series expansion of the quasi-linear viscoelastic model was chosen to model the viscoelastic properties of the collagen fibers. Material parameters were determined by using the simplex method to minimize the sum of squared errors between model results and experimental stress relaxation data of tissue in tension. Collagen elastic fiber modulus was calculated by fitting to the equilibrium data and viscoelastic parameters were determined by fitting to the relaxation curve. Results of newborn (~1-3 week old) untreated bovine articular cartilage explants from the patellar femoral groove as well as explants cultured in transforming growth factor-β1 (TGF-β1), from both the superficial (~0-0.5 mm from the articular surface) and middle (~0.5-1.0 mm from the articular surface) layers were compared to examine the effects of TGF- β1. TGF-β1 has been shown to maintain or even enhance mechanical properties of articular cartilage in compression and tension [2, 3] and this study continues with the hope that it may be used to improve tissue engineering of mature cartilage to better survive implantation in vivo for the successful repair of articular cartilage defects. Results show that TGF-β1 has a maturational effect on collagen, causing the tissue to become stiffer through an increase in elastic collagen fiber modulus and less viscous through shorter relaxation time and less stress relaxation (tissue retained a higher percentage of residual stress). The results of this study further advance the understanding of the effects of location and treatment with TGF-β1.
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Kundrat, Mary Elizabeth. "A Comprehensive Series for Predicting Bone Dynamics: Forecasting Osseous Tissue Formation using the Molecular Structure of a Biomaterial." University of Dayton / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1282842002.

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Комісаренко, Руслан Володимирович. "Реконструкція технологічного потоку Приватного акціонерного товариства "Київський картонно-паперовий комбінат" з виробництва паперу-основи для рушників". Master's thesis, Київ, 2018. https://ela.kpi.ua/handle/123456789/27136.

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Актуальність теми: підвищення рівня якості паперу-основи для рушників та продуктивності технологічного обладнання з виготовлення паперу-основи для рушників на ПрАТ "Київський картонно-паперовий комбінат". Мета і задачі дослідження: розроблення заходів та вирішення ряду задач з метою реконструкції технологічного потоку виробництва паперу-основи для рушників і підвищення якості продукції, що виготовляється. Об’єкт дослідження: технологічний процес виробництва паперу основи для рушників. Предмет дослідження: вихідні волокнисті напівфабрикати, режими роботи обладнання та технологія виготовлення паперу основи для рушників. Методи дослідження: літературний пошук, дослідження технологічних режимів, фізико-механічні методи випробування отриманих зразків в лабораторних умовах фабрики в процесі реконструкції технологічного потоку. Практичне значення одержаних результатів: реконструкція технологічного потоку дає можливість зменшити собівартість і, разом з тим, підвищити якість готової продукції, що виготовляється на ПрАТ Київський картонно-паперовий комбінат. Апробація результатів дисертації: Запропоновано шляхи реконструкції технологічного потоку Приватного акціонерного товариства "Київський картонно-паперовий комбінат" з виробництва паперу основи для рушників. Основні етапи реконструкції, викладені в дисертаційній роботі, знайшли відображення в тезах конференцій та статті: - Комісаренко Р.В., Плосконос В.Г. "Підвищення рентабельності і економія енергії у виробництві санітарно-гігієнічних видів паперу"\\Зб.тез доповідей XXIII Всеукраїнської наук.-практ.конф. студ.,аспір. і молодих вчених “Обладнання хімічних виробництв і підприємств будівельних матеріалів”, К.: 2018 ,28-29.11,с.68-69. - Плосконос В.Г., Комісаренко Р.В., Котлярська Н.О., Якименко О.С. Використання свіжої води в процесах виробництва целюлозно-паперової продукції та необхідність скорочення її споживання //Міжнародний науковометричний журнал "Інтернаука". - 2018. - №17(57),т.1, с.61-64. Публікації: за темою дисертації опубліковано статтю в науковометричному журналі "Інтернаука" та 2 тези доповідей на міжнародних та республіканських конференціях.<br>Relevance of the theme: raising the level of quality of the paper-base for towels and productivity of technological equipment for the production of paper-base for towels at PJSC "Kyiv Cardboard and Paper Mill". Purpose and objectives of the study: development of measures and solving a number of problems with a view to reconstructing the technological flow of production of paper-based for towels and improving the quality of manufactured products. Object of research: technological process of paper production basis Object of research: the technological process of producing paper bases for towels. Subject of research: output fibrous semi-finished products, operating modes of equipment and technology for producing paper bases for towels. Methods of research: literary search, research of technological regimes, physical and mechanical methods of testing the samples obtained in laboratory conditions of the factory in the process of reconstruction of the technological flow. The practical value of the results: the reconstruction of the technological flow makes it possible to reduce the cost and, at the same time, improve the quality of finished products, produced at PrAT Kyiv Cardboard and Paper Mill Testing the results of the dissertation: the ways of reconstruction of the technological flow of the Private Joint-Stock Company "Kiev Cardboard and Paper Mill" for the production of paper for the basis for towels are proposed. The main stages of the reconstruction, presented in the dissertation, were reflected in the theses of conferences and articles: - Komisarenko RV, Ploskonos VG "Increasing profitability and saving energy in the production of sanitary-hygienic types of paper" \\ Zb.tez reports XXIII All-Ukrainian Sciences. Prakt.konf. studio, aspiration and young scientists "Equipment of chemical manufactures and enterprises of building materials", K .: 2018, 28-29.11, p.68-69. - Ploskonos VG, Komisarenko RV, Kotlyarskaya N.O., Yakimenko O.S. Use of fresh water in the processes of production of pulp and paper products and the need to reduce its consumption // International scientific and mathematical journal "Interna-nauka". - 2018. - № 17 (57), t.1, p.61-64. Publications: on the topic of the dissertation an article was published in the scientific-science journal "Internet Science" and 2 theses of reports at international and republican conferences.
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Prasad, Saurabh. "Radio over fiber for 3G cellular System." Thesis, Kolhapur Institute of Technology College of Engineering, 2010. http://hdl.handle.net/10919/71529.

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The demand for bandwidth is increasing vigorously. Thus wired network is using fiber optic telephone line instead of coaxial cable. The concept of Fiber to the Home (FTTH) is really coming into picture. Few countries like Japan, Korea etc are leading in this technology. But now the major challenge is how to provide the high speed internet connection wirelessly. Thus the change is to integrate the wireless and optical fiber communication.<br>Wireless Optical Communication
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Crapeau, Myriam. "Facteurs cellulaires déterminant la propagation du prion [URE3] dans la levure Saccharomyces cerevisiae." Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21728/document.

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Une protéine prion peut adopter deux conformations distinctes, l’une cellulaire et l’autre prion. La conformation prion est le résultat de son agrégation en fibre amyloïde. Cette fibre est le support de l’information prion à partir duquel les isoformes cellulaires sont convertis en forme prion de façon autocatalytique. La transmission de l’information prion repose donc sur la transmission de cette fibre au cours des divisions cellulaires, qui est réalisée par de petits polymères. Ceux-ci sont le résultat d’un équilibre entre la fragmentation et la polymérisation de la fibre. Une perturbation de cet équilibre provoque une agrégation massive de la protéine prion, menant à la perte de l’information prion.L’objectif de ma thèse était de comprendre ce qui définit in vivo la transmission du prion. Mon modèle d’étude est la protéine Ure2p propageant le prion [URE3] dans la levure S. cerevisiae. J’ai montré que la concentration cellulaire d’Ure2p détermine la vitesse d’agrégation de la protéine prion et donc son efficacité de transmission. En effet, de trop fortes concentrations cellulaires sont incompatibles avec la propagation du prion. La concentration cellulaire d’Ure2p définit également la diversité des souches prions. Un crible génétique m’a permit de mettre en évidence que la présence de séquences centromériques surnuméraires dans la cellule interfère avec la transmission du prion [URE3]. Le même phénomène est observé avec une augmentation du niveau de ploïdie de la cellule. Dans les deux cas, la surexpression du chaperon Hsp104 restaure une propagation normale du prion<br>A prion protein can adopt two distinct conformations, one cellular and one prion. Prion conformation is the result of its aggregation into amyloid fibers. This fiber is the support of the prion information from which the cellular isoforms are converted into prion form by autocatalytic manner. The prion information transmission is therefore based on the transmission of this fiber during cell division, which is done by small polymers. These are the result of a balance between fragmentation and polymerization of the fiber. A disturbance of this balance causes a massive aggregation of the prion protein, leading to the prion information loss.The objective of my thesis was to understand what defined in vivo the prion transmission. My studying model was the Ure2p protein propagating the [URE3] prion in S. cerevisiae yeast. I showed that the Ure2p cellular concentration determined the aggregation speed of the prion protein and thus its transmission efficiency. Indeed, too high cellular concentrations are incompatible with the prion propagation. The cellular concentration of Ure2p also defines the prion strains diversity. A genetic screen allowed me to highlight that the presence of centrometric supernumerary sequences in the cell interferes with the [URE3] prion transmission. The same phenomenon is observed with an increase in the cell ploidy. In both cases, overexpression of the Hsp104 chaperone restores normal prion propagation
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Books on the topic "Cellular fibers"

1

Metals, Institute of, ed. Wood: Nature's cellular, polymeric, fibre-composite. Institute of Metals, 1989.

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Davis, John M. G., and Marie-Claude Jaurand, eds. Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79041-6.

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Telecommunication transmission systems: Microwave, fiber optic, mobile cellular radio, data, and digital multiplexing. McGraw-Hill, 1993.

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Lin, Wing Shan Linda. effect of moisture and other volatiles on the cellular structure of plastic/wood-fiber composite foams. National Library of Canada, 2001.

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Pastrone, Franco, and J. F. Ganghoffer. Mechanics of microstructured solids 2: Cellular materials, fibre reinforced solids and soft tissues. Springer, 2010.

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Bernt, Phyllis. The impact of alternative technologies on universal service and competition in the local loop. National Regulatory Research Institute, 1992.

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Mass.) AMS Special Session on Radon Transforms and Geometric Analysis (2012 Boston. Geometric analysis and integral geometry: AMS special session in honor of Sigurdur Helgason's 85th birthday, radon transforms and geometric analysis, January 4-7, 2012, Boston, MA ; Tufts University Workshop on Geometric Analysis on Euclidean and Homogeneous Spaces, January 8-9, 2012, Medford, MA. Edited by Quinto, Eric Todd, 1951- editor of compilation, Gonzalez, Fulton, 1956- editor of compilation, Christensen, Jens Gerlach, 1975- editor of compilation, and Tufts University. Workshop on Geometric Analysis on Euclidean and Homogeneous Spaces. American Mathematical Society, 2013.

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1943-, Harris Curtis C., Lechner John F, and Brinkley B. R, eds. Cellular and molecular aspects of fiber carcinogenesis. Cold Spring Harbor Laboratory Press, 1991.

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Harris, Curtis C., and John F. Lechner. Cellular and Molecular Aspects of Fiber Carcinogenesis (Current Communications in Cell and Molecular Biology , Vol 2) (Current Communications in Cell and Molecular Biology). Cold Spring Harbor Laboratory Press, 1991.

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Dinwoodie, J. M. Wood: Nature's Cellular, Polymeric Fibre-Composite. Maney Pub, 1989.

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Book chapters on the topic "Cellular fibers"

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Davis, Janet B., and David B. Marshall. "Connected Fibers: Fiber Felts and Mats." In Cellular Ceramics. Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/3527606696.ch2d.

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Konishi, Masato, and Satoshi Kurihara. "Radial Spread of Aequorin Ca2+ Signal in Single Frog Skeletal Muscle Fibers." In Cellular Function and Metabolism. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3078-7_9.

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Pette, Dirk, and Robert S. Staron. "Cellular and molecular diversities of mammalian skeletal muscle fibers." In Reviews of Physiology, Biochemistry and Pharmacology. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/3540528806_3.

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Pagé, M., and L. Dumas. "Increased Cellular Density in the Presence of Asbestos Fibers." In In Vitro Effects of Mineral Dusts. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70630-1_70.

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Rey, Françoise, C. Boutin, P. Dumortier, J. R. Viallat, and P. De Vuyst. "Carcinogenic Asbestos Fibers in the Parietal Pleura." In Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79041-6_31.

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Clayson, David B., Eric Lok, Eduardo A. Nera, et al. "Calories, Fat, Fibers, and Cellular Proliferation in Swiss Webster Mice." In Exercise, Calories, Fat and Cancer. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4684-7953-9_8.

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Sahu, Anand Prakash. "Pleural Lesions Induced by Mineral Dusts, Fibers and Chemicals." In Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79041-6_32.

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Steinmetz, Joseph E., Christine G. Logan, and Richard F. Thompson. "Essential Involvement of Mossy Fibers in Projecting the CS to the Cerebellum during Classical Conditioning." In Cellular Mechanisms of Conditioning and Behavioral Plasticity. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9610-0_14.

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Marczynski, B., T. Kerenyi, W. Marek, and X. Baur. "Induction of DNA — Damage after Rats Exposure to Crocidolite Asbestos Fibers." In Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79041-6_21.

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Morano, I. "Effects of different expression and posttranslational modifications of myosin light chains on contractility of skinned human cardiac fibers." In Cellular and Molecular Alterations in the Failing Human Heart. Steinkopff, 1992. http://dx.doi.org/10.1007/978-3-642-72474-9_11.

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Conference papers on the topic "Cellular fibers"

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Estcheverry, Sebastián, Aziza Sudirman, Fredrik Laurell, and Walter Margulis. "Playing Cellular Golf in Microstructured Fibres." In Workshop on Specialty Optical Fibers and their Applications. OSA, 2015. http://dx.doi.org/10.1364/wsof.2015.wf1a.1.

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Metter, Robert B., Brendon M. Baker, Jason A. Burdick, and Robert L. Mauck. "Enhanced Cellular Infiltration With Removal of Sacrificial Fibers From a Dual-Polymer Nanofibrous Scaffold." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176487.

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The meniscus is a wedge-shaped, fibrocartilaginous tissue that stabilizes the knee joint by transmitting and distributing loads from the rounded femur to the flat tibial plateau [1]. With normal use, the meniscus experiences large tensile stresses along its circumferentially oriented collagen fibers [2]. Interruption of these fibers with injury inhibits load transfer and precipitates the early onset of osteoarthritis in the adjacent articular surfaces. Endogenous healing of the avascular region of the meniscus is limited, and restoration of fiber architecture is difficult to achieve [3]. The current, standard treatment of partial meniscectomy alleviates symptoms but does not restore mechanical function.
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LANGHORST, AMY, ANSHUL SINGHAL, DEBORAH MIELEWSKI, MIHAELA BANU, and ALAN TAUB. "NANOPARTICLE MODIFICATION OF NATURAL FIBERS FOR STRUCTURAL COMPOSITES." In Thirty-sixth Technical Conference. Destech Publications, Inc., 2021. http://dx.doi.org/10.12783/asc36/35868.

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Natural fibers are a lightweight, carbon negative alternative to synthetic reinforcing agents in polymer composites. However, natural fibers typically exhibit lower mechanical performance than glass fibers due to weak interfacial adhesion between plant cells in the fiber and damage to the fibers during extraction from a plant stem. However, improvement of natural fiber mechanical performance could enable their wide-scale incorporation in structural composite applications, significantly reducing composite weight and carbon footprint. This study seeks to develop a novel, cost-effective method to significantly improve natural fiber stiffness via repair of damage caused by extraction and/ or stiffening of the weak cellular interfaces within a natural fiber. Supercritical fluids have been shown to be capable of swelling and plasticizing amorphous polymers, increasing additive absorption. In this work. supercritical-carbon dioxide (scCO2) was used as a solvent to assist with infusion of nanoparticles into flax fibers at pressures ranging from 1200-4000psi. Fiber analysis with Plasma Focused Ion Beam-Scanning Electron Microscopy (PFIB-SEM) showed that nanoparticles were capable of penetrating and bridging openings between cells, suggesting the ability for nanoparticle treatment to assist with crack repair. Additionally, treated fibers contained uniform surface coatings of nanoparticles, potentially reducing fiber porosity and modifying interfacial properties when embedded in a polymer matrix. Overall, this method of nanoparticle reinforcement of natural fibers could enable development of high-performance lightweight, low-carbon footprint composites for transportation or industrial applications.
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Yamada, Hiroshi, Tohru Takemasa, and Takami Yamaguchi. "Mechanically Optimized Orientation of Intracellular Stress Fibers Under Cyclic Stretch." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1419.

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Abstract To elucidate the orientation of stress fibers in a cultured endothelial cell under cyclic stretch, we hypothesized that a stress fiber aligns so as to minimize the summation of its length change under cyclic stretch, and that there is a limit in the sensitivity of cellular response to the mechanical stimulus. Results from numerical simulations based on the continuum mechanics describe the experimental observations under uniaxial stretch well. They give us an insight to the biological phenomenon of the orientation in stress fibers under biaxial stretch from the viewpoint of mechanical engineering.
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Baucom, Jared N., Mohammed A. Zikry, and Yiping Qiu. "Dynamic Failure Mechanisms in 3D Cellular Woven Composite Systems." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/amd-25422.

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Abstract The role of porosity on failure resistance of 3-D woven fiber reinforced epoxy panels under dynamic loading condition is investigated. Incident and residual velocities are measured to determine the energy absorption by the target. Material behavior segregates by porosity, and the more highly porous samples absorb a greater amount of specific energy. The reason for this may be due to the deflection of matrix cracks by pores or due to the greater flexibility of the fibers to absorb energy through tensile straining. Although porosity is generally an undesirable property in textile composites, the induction of porosity may result in reduced panel weight without degradation of ballistic performance, which is a clear advantage for weight minimization.
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Wu, Yang, Jerry Y. H. Fuh, and Yoke San Wong. "Crimped Fiber Printing via E-Jetting for Tissue Engineering." In ASME 2017 12th International Manufacturing Science and Engineering Conference collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/msec2017-2742.

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A regular pattern called crimp is an essential morphological feature of collagen fibers in native tendon. In this study, the direct crimp writing (DCW) and zig-zag pattern writing (ZPW) were developed based on electrohydrodynamic jet printing (E-jetting) process to fabricate the crimped fibers. For the DCW process, the fibers were deposited with the linear movement of stage, and the crimps (crimp angle: ∼ 46°; crimp length: ∼630 μm; fiber diameter: ∼100 μm) were formed from the spinning of fibers. For the ZPW process, the fibers was printed via the zig-zag moving path, and the effects of a vital process parameter (i.e. dwell time) on the fiber characteristics were investigated to obtain controllable and regular crimped fibers. The result of mechanical testing showed that the ZPW fibers exhibited the “toe” and linear regions with different Young’s modulus (4 ± 1 MPa and 23 ± 4 MPa, respectively), while DCW fibers were found only with linear region. Compared with DCW process, the ZPW process was able to fabricate crimped fibers in a more controllable pathway. The human tenocytes were also seeded on the ZPW fibers to investigate the cellular alignment. This study suggested that ZPW process was capable of printing crimped fibers which mimicked the fiber profile in human tendon, and has the potential in scaffold fabrication for tendon tissue engineering.
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Carruthers, Christopher A., Bryan Good, Antonio D’Amore, Rouzbeh Amini, Joseph H. Gorman, and Michael S. Sacks. "Physiological Micromechanics of the Anterior Mitral Valve Leaflet." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53637.

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An improved understanding of mitral valve (MV) function remains an important goal for determining mechanisms underlying valve disease and for developing novel therapies. Critical to heart valve tissue homeostasis is the valvular interstitial cells (VICs), which reside in the interstitium and maintain the extracellular matrix (ECM) through both protein synthesis and enzymatic degradation [1]. There is scant experimental data on the alterations of the MV fiber network reorganization as a function of load, which is critical for implementation of computational strategies that attempt to link this meso-micro scale phenomenon. The observed large scale deformations experienced by VICs could be implicated in mechanotransduction [2], i.e., translation of mechanical stimuli into biochemical signals. Consequently, our goal is to quantitatively connect organ level loads to cellular deformation as a function of the ECM fiber network. We hypothesize that cellular deformations are likely a complex function of collagen and elastin fiber mechanical properties, architecture, and cellular coupling to these fibers.
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Vázquez, C., D. S. Montero, W. Ponce, et al. "Multimode fibers in millimeter-wave evolution for 5G cellular networks." In SPIE OPTO, edited by Benjamin B. Dingel and Katsutoshi Tsukamoto. SPIE, 2016. http://dx.doi.org/10.1117/12.2216107.

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Kluge, Jonathan A., Rudra A. Pampati, Mara L. Schenker, et al. "Delivery of Active FGF-2 From Mechanically-Stable Biological Nanofibers Accelerates Cell Ingress Into Multifiber Composites." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53955.

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Fibrocartilaginous tissues such as the meniscus and annulus fibrosus serve critical load-bearing roles, relying on arrays of highly organized collagen fibers to resist tensile loads [1]. As these specialized structures are often injured, there exists great demand for engineered tissues for repair or replacement. Cell-laden aligned nanofibrous scaffolds formed from poly(ε-caprolactone) (PCL) have shown promise in achieving tissuelike mechanical and biochemical properties and can direct cellular and matrix organization in vitro [2]. A current limitation of nanofibrous scaffolds, however, is a slow rate of cellular infiltration, particularly in thick scaffolds. To address this, dynamic composite nanofibrous scaffolds have been fabricated via multi-fiber spinning [3], which can offer tunable modes of degradation depending on the polymer sources. For example, water-soluble polyethylene oxide (PEO) fibers can be co-spun with PCL to improve porosity and hasten cell ingress [4]. Incorporation of additional tunable and bioactive polymer sources may add greater versatility to these composite systems. For example, aqueous-based silk fibroin can be used as a slow-degrading, mechanically strong composite fiber component [5] into which active biologic factors (drugs, growth factors) can be incorporated [6]. Variably-degradable silk fibers can be formed by modulating post-spinning treatments, and protein release kinetics can likewise be manipulated by the physical crosslinking method [7]. We hypothesized that incorporation of robust and tunable silk protein-based fibers into a composite of slow-degrading synthetic fibers would provide mechanical function while delivering active biologic factors to expedite cell proliferation and encourage more rapid construct colonization. To test this hypothesis, we characterized the release kinetics of recombinant FGF-2 from silk fibers and its bioactivity in vitro and in a rat subcutaneous implant model.
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Baker, Stephen, Justin Sigley, Christine Carlisle, et al. "Nanomechanics of Electrospun Fibers for Tissue Engineering." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13287.

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Understanding the material properties of the nanofibers comprising electrospun scaffolds for tissue engineering will elucidate the mechanotransduction of cells seeded onto and attached those scaffolds. The overall mechanical properties of any structure built from fibers depend on 1) the architecture, 2) the properties of the constituent single fibers, and 3) the junctions between fibers. All three must be known to design a structure with predictable mechanical properties. We hypothesize that a basic understanding of the nanolevel mechanical properties of individual electrospun fibers will enable accurate prediction of the overall cellular response and bulk mechanical behavior of electrospun tissue scaffolds.
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Reports on the topic "Cellular fibers"

1

Garrity, John, and Arndt Husar. Digital Connectivity and Low Earth Orbit Satellite: Constellations Opportunities for Asia and the Pacific. Asian Development Bank, 2021. http://dx.doi.org/10.22617/wps210156-2.

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Satellite communication plays an important role in the global connectivity ecosystem. It connects rural and remote populations, provides backhaul connectivity to mobile cellular networks, and enables rapid communications for emergency and disaster responses. Low Earth orbit constellations may prove to be transformational to the connectivity landscape based on their global coverage and their suitability for areas not served by fiber optic cable networks. The Asian Development Bank’s developing member countries are well placed to benefit from this expansion of internet connectivity. It will be particularly valuable for small island developing states and landlocked developing countries with limited international bandwidth internet.
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Lau, Kam. Device & System Research in Millimeter Wave Fiber-Optic Link & Distributed Antenna Networks for Cellular and Personal Communitions. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada374268.

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Ghanim, Murad, Joe Cicero, Judith K. Brown, and Henryk Czosnek. Dissection of Whitefly-geminivirus Interactions at the Transcriptomic, Proteomic and Cellular Levels. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7592654.bard.

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Our project focuses on gene expression and proteomics of the whitefly Bemisia tabaci (Gennadius) species complex in relation to the internal anatomy and localization of expressed genes and virions in the whitefly vector, which poses a major constraint to vegetable and fiber production in Israel and the USA. While many biological parameters are known for begomovirus transmission, nothing is known about vector proteins involved in the specific interactions between begomoviruses and their whitefly vectors. Identifying such proteins is expected to lead to the design of novel control methods that interfere with whitefly-mediated begomovirus transmission. The project objectives were to: 1) Perform gene expression analyses using microarrays to study the response of whiteflies (B, Q and A biotypes) to the acquisition of begomoviruses (Tomato yellow leaf curl (TYLCV) and Squash leaf curl (SLCV). 2) Construct a whitefly proteome from whole whiteflies and dissected organs after begomovirus acquisition. 3) Validate gene expression by q-RTPCR and sub-cellular localization of candidate ESTs identified in microarray and proteomic analyses. 4) Verify functionality of candidate ESTs using an RNAi approach, and to link these datasets to overall functional whitefly anatomical studies. During the first and second years biological experiments with TYLCV and SLCV acquisition and transmission were completed to verify the suitable parameters for sample collection for microarray experiments. The parameters were generally found to be similar to previously published results by our groups and others. Samples from whole whiteflies and midguts of the B, A and Q biotypes that acquired TYLCV and SLCV were collected in both the US and Israel and hybridized to B. tabaci microarray. The data we analyzed, candidate genes that respond to both viruses in the three tested biotypes were identified and their expression that included quantitative real-time PCR and co-localization was verified for HSP70 by the Israeli group. In addition, experiments were undertaken to employ in situ hybridization to localize several candidate genes (in progress) using an oligonucleotide probe to the primary endosymbiont as a positive control. A proteome and corresponding transcriptome to enable more effective protein identification of adult whiteflies was constructed by the US group. Further validation of the transmission route of begomoviruses, mainly SLCV and the involvement of the digestive and salivary systems was investigated (Cicero and Brown). Due to time and budget constraints the RNAi-mediated silencing objective to verify gene function was not accomplished as anticipated. HSP70, a strong candidate protein that showed over-expression after TYLCV and SLCV acquisition and retention by B. tabaci, and co-localization with TYLCV in the midgut, was further studies. Besides this protein, our joint research resulted in the identification of many intriguing candidate genes and proteins that will be followed up by additional experiments during our future research. To identify these proteins it was necessary to increase the number and breadth of whitefly ESTs substantially and so whitefly cDNAs from various libraries made during the project were sequenced (Sanger, 454). As a result, the proteome annotation (ID) was far more successful than in the initial attempt to identify proteins using Uniprot or translated insect ESTs from public databases. The extent of homology shared by insects in different orders was surprisingly low, underscoring the imperative need for genome and transcriptome sequencing of homopteran insects. Having increased the number of EST from the original usable 5500 generated several years ago to &gt;600,000 (this project+NCBI data mining), we have identified about one fifth of the whitefly proteome using these new resources. Also we have created a database that links all identified whitefly proteins to the PAVEdb-ESTs in the database, resulting in a useful dataset to which additional ESTS will be added. We are optimistic about the prospect of linking the proteome ID results to the transcriptome database to enable our own and other labs the opportunity to functionally annotate not only genes and proteins involved in our area of interest (whitefly mediated transmission) but for the plethora of other functionalities that will emerge from mining and functionally annotating other key genes and gene families in whitefly metabolism, development, among others. This joint grant has resulted in the identification of numerous candidate proteins involved in begomovirus transmission by B. tabaci. A next major step will be to capitalize on validated genes/proteins to develop approaches to interfere with the virus transmission.
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